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Citations to this article

Probing cell type–specific functions of Gi in vivo identifies GPCR regulators of insulin secretion
Jean B. Regard, … , Matthias Hebrok, Shaun R. Coughlin
Jean B. Regard, … , Matthias Hebrok, Shaun R. Coughlin
Published November 8, 2007
Citation Information: J Clin Invest. 2007;117(12):4034-4043. https://doi.org/10.1172/JCI32994.
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Research Article Technical Advance Cardiology Article has an altmetric score of 6

Probing cell type–specific functions of Gi in vivo identifies GPCR regulators of insulin secretion

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Abstract

The in vivo roles of the hundreds of mammalian G protein–coupled receptors (GPCRs) are incompletely understood. To explore these roles, we generated mice expressing the S1 subunit of pertussis toxin, a known inhibitor of Gi/o signaling, under the control of the ROSA26 locus in a Cre recombinase–dependent manner (ROSA26PTX). Crossing ROSA26PTX mice to mice expressing Cre in pancreatic β cells produced offspring with constitutive hyperinsulinemia, increased insulin secretion in response to glucose, and resistance to diet-induced hyperglycemia. This phenotype underscored the known importance of Gi/o and hence of GPCRs for regulating insulin secretion. Accordingly, we quantified mRNA for each of the approximately 373 nonodorant GPCRs in mouse to identify receptors highly expressed in islets and examined the role of several. We report that 3-iodothyronamine, a thyroid hormone metabolite, could negatively and positively regulate insulin secretion via the Gi-coupled α2A-adrenergic receptor and the Gs-coupled receptor Taar1, respectively, and protease-activated receptor–2 could negatively regulate insulin secretion and may contribute to physiological regulation of glucose metabolism. The ROSA26PTX system used in this study represents a new genetic tool to achieve tissue-specific signaling pathway modulation in vivo that can be applied to investigate the role of Gi/o-coupled GPCRs in multiple cell types and processes.

Authors

Jean B. Regard, Hiroshi Kataoka, David A. Cano, Eric Camerer, Liya Yin, Yao-Wu Zheng, Thomas S. Scanlan, Matthias Hebrok, Shaun R. Coughlin

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Citations to this article (121)

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S Raab, H Wang, S Uhles, N Cole, R Alvarez-Sanchez, B Künnecke, C Ullmer, H Matile, M Bedoucha, RD Norcross, N Ottaway-Parker, D Perez-Tilve, KC Knape, MH Tschöp, MC Hoener, S Sewing
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RGS4 is a negative regulator of insulin release from pancreatic  -cells in vitro and in vivo
IR de Azua, M Scarselli, E Rosemond, D Gautam, W Jou, O Gavrilova, PJ Ebert, P Levitt, J Wess
Proceedings of the National Academy of Sciences 2010
Local protease signaling contributes to neural tube closure in the mouse embryo
E Camerer, A Barker, DN Duong, R Ganesan, H Kataoka, I Cornelissen, MR Darragh, A Hussain, YW Zheng, Y Srinivasan, C Brown, SM Xu, JB Regard, CY Lin, CS Craik, D Kirchhofer, SR Coughlin
Developmental Cell 2010
Structure, biological functions and applications of the AB5 toxins
T Beddoe, AW Paton, JL Nours, J Rossjohn, JC Paton
Trends in Biochemical Sciences 2010
G protein coupled receptors in embryonic stem cells: a role for Gs-alpha signaling
BT Layden, M Newman, F Chen, A Fisher, WL Lowe
PloS one 2010
Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications
IR de Azua, D Gautam, JM Guettier, J Wess
Trends in endocrinology and metabolism: TEM 2010
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine
AG Ianculescu, EC Friesema, TJ Visser, KM Giacomini, TS Scanlan
Molecular BioSystems 2010
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice
HN Panas, LJ Lynch, EJ Vallender, Z Xie, GL Chen, SK Lynn, TS Scanlan, GM Miller
Journal of Neuroscience Research 2010
G o Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic  -Cells
A Zhao, M Ohara-Imaizumi, M Brissova, RK Benninger, Y Xu, Y Hao, J Abramowitz, G Boulay, AC Powers, D Piston, M Jiang, S Nagamatsu, L Birnbaumer, G Gu
Diabetes 2010
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak
Eric Camerer, Jean B. Regard, Ivo Cornelissen, Yoga Srinivasan, Daniel N. Duong, Daniel Palmer, Trung H. Pham, Jinny S. Wong, Rajita Pappu and Shaun R. Coughlin
Journal of Clinical Investigation 2009
A chemical-genetic approach to study G protein regulation of   cell function in vivo
JM Guettier, D Gautam, M Scarselli, IR de Azua, JH Li, E Rosemond, X Ma, FJ Gonzalez, BN Armbruster, H Lu, BL Roth, J Wess
Proceedings of the National Academy of Sciences 2009
G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies
K Nakamura, N Salomonis, K Tomoda, S Yamanaka, BR Conklin
PloS one 2009
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system
A Bradaia, G Trube, H Stalder, RD Norcross, L Ozmen, JG Wettstein, A Pinard, D Buchy, M Gassmann, MC Hoener, B Bettler
Proceedings of the National Academy of Sciences 2009
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature
JJ Maguire, WA Parker, SM Foord, TI Bonner, RR Neubig, AP Davenport
Pharmacological reviews 2009
The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1))
ES Tan, JC Naylor, ES Groban, JR Bunzow, MP Jacobson, DK Grandy, TS Scanlan
ACS chemical biology 2009
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
B Ahrén
Nature Reviews Drug Discovery 2009
Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo
WJ Wood, T Geraci, A Nilsen, AE DeBarber, TS Scanlan
Chembiochem : a European journal of chemical biology 2009
Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling
G Li, H Kataoka, SR Coughlin, SJ Pleasure
Development (Cambridge, England) 2009
Anatomical Profiling of G Protein-Coupled Receptor Expression
JB Regard, IT Sato, SR Coughlin
Cell 2008
The Role of Vasoactive Intestinal Peptide (VIP) in Megakaryocyte Proliferation
C Nam, AJ Case, BS Hostager, MS O’Dorisio
Journal of Molecular Neuroscience 2008
Cardiac effects of thyronamines
R Zucchi, S Ghelardoni, G Chiellini
Heart Failure Reviews 2008
3-Iodothyronamine (T1AM): A New Player on the Thyroid Endocrine Team?
TS Scanlan
Endocrinology 2008
A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function
S Puri, DA Cano, M Hebrok
Diabetes 2008
Identification and characterization of 3-iodothyronamine intracellular transport
AG Ianculescu, KM Giacomini, TS Scanlan
Endocrinology 2008
Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum
AE DeBarber, T Geraci, VP Colasurdo, SA Hackenmueller, TS Scanlan
Journal of chromatography. A 2008

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