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Citations to this article

Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients
Renee C. Tschumper, … , Gordon W. Dewald, Diane F. Jelinek
Renee C. Tschumper, … , Gordon W. Dewald, Diane F. Jelinek
Published December 6, 2007
Citation Information: J Clin Invest. 2008;118(1):306-315. https://doi.org/10.1172/JCI32625.
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Research Article Oncology

Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients

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Abstract

Survival of patients with B cell chronic lymphocytic leukemia (B-CLL) can be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV). Patients without mutations (unmutated [UM]) are at greater risk for disease progression and death than patients with mutations (M). Despite this broad prognostic difference, there remains wide intragroup variation in the clinical outcome of UM patients, especially those with low/intermediate Rai risk disease. We evaluated UM B-CLL patients with low/intermediate Rai risk to determine the relationship between IGHV, IGH diversity (IGHD), and IGH joining (IGHJ) gene usage and time to treatment (TTT). Irrespective of IGHV usage, UM patients whose B-CLL cells expressed the IGHD3-3 gene had a significantly shorter TTT than other UM B-CLL patients, and specifically, use of the IGHD3-3 gene in reading frame 2 (RF2) predicted shorter TTT. As expected, Rai risk was the best single prognostic factor for TTT; however, IGHD usage was also a significant variable for TTT. Therefore, both IGHD gene and IGHD RF usage have prognostic relevance in UM B-CLL patients with low/intermediate Rai risk disease. In addition, these data support the concept that antigen-driven selection of specific Ig receptors plays a role in the clinical course of B-CLL.

Authors

Renee C. Tschumper, Susan M. Geyer, Megan E. Campbell, Neil E. Kay, Tait D. Shanafelt, Clive S. Zent, Grzegorz S. Nowakowski, Timothy G. Call, Gordon W. Dewald, Diane F. Jelinek

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Total citations by year

Year: 2023 2021 2014 2012 2011 2008 Total
Citations: 1 1 2 1 2 1 8
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (8)

Title and authors Publication Year
Characterization of clonal immunoglobulin heavy V-D-J gene rearrangements in Chinese patients with chronic lymphocytic leukemia: Clinical features and molecular profiles.
Deng X, Zhang M, Wang J, Zhou X, Xiao M
Frontiers in Oncology 2023
Development of a Prognostic Nomogram for Acute Myeloid Leukemia on IGHD Gene Family
Q Qiu, P Zhang, N Zhang, Y Shen, S Lou, J Deng
International journal of general medicine 2021
Use of positron emission tomography-computed tomography in the management of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
MJ Conte, DA Bowen, GA Wiseman, KG Rabe, SL Slager, SM Schwager, TG Call, DS Viswanatha, CS Zent
Leukemia & Lymphoma 2014
Survival analysis in hematologic malignancies: recommendations for clinicians
J Delgado, A Pereira, N Villamor, A Lopez-Guillermo, C Rozman
Haematologica 2014
Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation
BK Arendt, DK Walters, X Wu, RC Tschumper, PM Huddleston, KJ Henderson, A Dispenzieri, DF Jelinek
Leukemia 2012
IGHV gene rearrangements as outcome predictors for CLL patients: experience of Ukrainian group
I Kryachok, I Abramenko, N Bilous, A Chumak, Z Martina, I Filonenko
Medical Oncology 2011
Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy
E Tsakou, A Agathagelidis, M Boudjoghra, T Raff, A Dagklis, M Chatzouli, T Smilevska, G Bourikas, H Merle-Beral, E Manioudaki-Kavallieratou, A Anagnostopoulos, M Brüggemann, F Davi, K Stamatopoulos, C Belessi
Molecular Medicine 2011
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
CC Chu, R Catera, K Hatzi, XJ Yan, L Zhang, XB Wang, HM Fales, SL Allen, JE Kolitz, KR Rai, N Chiorazzi
Blood 2008

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