Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications
George A. Calin, Carlo M. Croce
George A. Calin, Carlo M. Croce
Published August 1, 2007
Citation Information: J Clin Invest. 2007;117(8):2059-2066. https://doi.org/10.1172/JCI32577.
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Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications

Abstract

There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

Authors

George A. Calin, Carlo M. Croce

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Figure 3

miRNA deregulation by chromosomal translocations.

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miRNA deregulation by chromosomal translocations. The main mechanisms (s...
The main mechanisms (some identified in patient samples [refs. 32, 53, 62, 64, 65], others only shown in the case of PCGs altered by translocations) of miRNA deregulation are schematically presented. On the left side, the primary genomic alteration is presented, while on the right side, the correspondent consequence at proteomic levels is shown. miR, miRNA gene.