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Citations to this article

Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus.
M Fleck, … , C K Edwards 3rd, J D Mountz
M Fleck, … , C K Edwards 3rd, J D Mountz
Published October 1, 1998
Citation Information: J Clin Invest. 1998;102(7):1431-1443. https://doi.org/10.1172/JCI3248.
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Research Article

Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus.

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Abstract

The role of Fas- and TNF-receptor 1 (TNF-R1)-mediated apoptosis in the clearance of virally infected cells and in the regulation of the immune response was analyzed after murine cytomegalovirus (MCMV) infection of C57BL/6 (B6)-+/+ mice, Fas-mutant B6-lpr/lpr mice, TNF-R1 knockout B6-tnfr0/0 mice, and double-deficient B6-tnfr0/0 lpr/lpr mice. There was approximately equivalent clearance of MCMV in B6-+/+, B6-tnfr0/0, and B6-lpr/lpr mice, and by day 28 no infectious virus could be detected in the liver, kidney, lung, or peritoneal exudate. However, delayed virus clearance was observed in B6-tnfr0/0 lpr/lpr mice. An acute inflammatory response occurred in the liver, lung, and kidney of all mice, which was most severe 7 d after MCMV infection, but resolved by day 28 in B6-+/+ and B6-tnfr0/0 mice, but not in B6-lpr/lpr or B6-tnfr0/0 lpr/lpr mice. These results indicate that apoptosis mediated by either Fas or TNF-R1 is sufficient for rapid clearance of the virus. However, apoptosis induced by Fas, but not TNF-R1, is required for the downmodulation of the immune response to the virus and prevention of a chronic inflammatory reaction.

Authors

M Fleck, E R Kern, T Zhou, J Podlech, W Wintersberger, C K Edwards 3rd, J D Mountz

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Total citations by year

Year: 2024 2021 2020 2019 2018 2017 2016 2014 2012 2010 2009 2007 2005 2003 2002 2001 2000 1999 Total
Citations: 1 1 1 2 2 1 2 1 1 1 1 1 3 4 2 5 4 1 34
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Citations to this article (34)

Title and authors Publication Year
Cytomegalovirus Biology Viewed Through a Cell Death Suppression Lens
Mocarski ES
Viruses 2024
Atypical cytomegalovirus retinal disease in pyroptosis-deficient mice with murine acquired immunodeficiency syndrome
JJ Carter, JG Nemeno, JJ Oh, JE Houghton, RD Dix
Experimental Eye Research 2021
TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis
P Mandal, AL McCormick, ES Mocarski
Viruses 2020
Caspase-8-dependent control of NK- and T cell responses during cytomegalovirus infection
Y Feng, LP Daley-Bauer, ES Mocarski
Medical Microbiology and Immunology 2019
Caspase-8 restricts antiviral CD8 T cell hyperaccumulation
Y Feng, LP Daley-Bauer, L Roback, H Guo, HS Koehler, M Potempa, LL Lanier, ES Mocarski
Proceedings of the National Academy of Sciences 2019
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse: FasL localization in the NK cell immune synapse
J Lee, NM Dieckmann, JR Edgar, GM Griffiths, RM Siegel
Immunity, Inflammation and Disease 2018
Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3
Y Feng, D Livingston-Rosanoff, L Roback, A Sundararajan, SH Speck, ES Mocarski, LP Daley-Bauer
Journal of immunology (Baltimore, Md. : 1950) 2018
CMV immune evasion and manipulation of the immune system with aging
SE Jackson, A Redeker, R Arens, D Baarle, SP van Berg, CA Benedict, L Čičin-Šain, AB Hill, MR Wills
GeroScience 2017
Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease
AA Adly, EA Ismail, NG Andrawes, MM Mahmoud, R Eladawy
Cytokine 2016
Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection
FI Fadel, MF Elshamaa, A Salah, M Nabhan, M Rasheed, S Kamel, D Kandil, EH Thabet
Transplant Immunology 2016
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, A Sundararajan, H Guo, L Roback, SH Speck, J Bertin, PJ Gough, S Balachandran, ES Mocarski
Proceedings of the National Academy of Sciences 2014
Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis
H Chien, RD Dix
Journal of virology 2012
TNF superfamily: a growing saga of kidney injury modulators
MD Sanchez-Niño, A Benito-Martin, S Gonçalves, AB Sanz, AC Ucero, MC Izquierdo, AM Ramos, S Berzal, R Selgas, M Ruiz-Ortega, J Egido, A Ortiz
Mediators of Inflammation 2010
Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies
K Crozat, E Vivier, M Dalod
Immunological Reviews 2009
Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia
RM Tucker, RJ Hendrickson, N Mukaida, RG Gill, CL Mack
Viral Immunology 2007
The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis
O Pleskoff, P Casarosa, L Verneuil, F Ainoun, P Beisser, M Smit, R Leurs, P Schneider, S Michelson, JC Ameisen
FEBS Journal 2005
NETWORK COMMUNICATIONS: Lymphotoxins, LIGHT, and TNF
CF Ware
Annual Review of Immunology 2005
A Lymphotoxin-IFN-β Axis Essential for Lymphocyte Survival Revealed during Cytomegalovirus Infection
TA Banks, S Rickert, CA Benedict, L Ma, M Ko, J Meier, W Ha, K Schneider, SW Granger, O Turovskaya, D Elewaut, D Otero, AR French, SC Henry, JD Hamilton, S Scheu, K Pfeffer, CF Ware
Journal of immunology (Baltimore, Md. : 1950) 2005
Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungs
B Singh, T Tschernig, M van Griensven, A Fieguth, R Pabst
Virchows Archiv 2003
Origin of late-onset autoimmune disease
HC Hsu, JD Mountz
Immunology and Allergy Clinics of North America 2003
Hyperoxia mediates acute lung injury and increased lethality in murine Legionella pneumonia: the role of apoptosis
K Tateda, JC Deng, TA Moore, MW Newstead, RP 3rd, N Kobayashi, K Yamaguchi, TJ Standiford
Journal of immunology (Baltimore, Md. : 1950) 2003
Dendritic Cells and Virus Infection
A Steinkasserer
2003
LYMPHOCYTE-MEDIATEDCYTOTOXICITY
JH Russell, TJ Ley
Annual Review of Immunology 2002
Biology and significance of T-cell apoptosis in the liver
S Park, D Murray, B John, IN Crispe
Immunology and Cell Biology 2002
Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage
BH Sohn, HB Moon, TY Kim, HS Kang, YS Bae, KK Lee, SJ Kim
Biochemical Journal 2001
Different effects of angiotensin II and catecholamine on renal cell apoptosis and proliferation in rats
T Aizawa, N Ishizaka, K Kurokawa, R Nagai, H Nakajima, JI Taguchi, M Ohno
Kidney International 2001
Lymphotoxins and Cytomegalovirus Cooperatively Induce Interferon-β, Establishing Host-Virus Détente
CA Benedict, TA Banks, L Senderowicz, M Ko, WJ Britt, A Angulo, P Ghazal, CF Ware
Immunity 2001
Apoptotic Cell Death in the Pathogenesis of Infectious Diseases
DH Dockrell
Journal of Infection 2001
Perforin and Fas in murine gammaherpesvirus-specific CD8+ T cell control and morbidity
GT Belz, RC Cardin, JW Brooks, PC Doherty, JP Christensen, DJ Topham
Journal of General Virology 2001
Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand–deficient mice
HG Zhang, M Fleck, ER Kern, D Liu, Y Wang, HC Hsu, P Yang, Z Wang, DT Curiel, T Zhou, JD Mountz
Journal of Clinical Investigation 2000
The divergent role of tumor necrosis factor receptors in infectious diseases
D Schlüter, M Deckert
Microbes and Infection 2000
Fas and Fas ligand in gut and liver
MJ Pinkoski, T Brunner, DR Green, T Lin
AJP Gastrointestinal and Liver Physiology 2000
Incoming Human Cytomegalovirus pp65 (UL83) Contained in Apoptotic Infected Fibroblasts Is Cross-Presented to CD8 + T Cells by Dendritic Cells
G Arrode, C Boccaccio, J Lulé, S Allart, N Moinard, JP Abastado, A Alam, C Davrinche
Journal of virology 2000
The Fas ligand/Fas system in renal injury
A Ortiz, C Lorz, J Egido
Nephrology Dialysis Transplantation 1999

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