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Citations to this article

Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection
Aleksandra Leligdowicz, … , Hilton Whittle, Sarah Rowland-Jones
Aleksandra Leligdowicz, … , Hilton Whittle, Sarah Rowland-Jones
Published October 1, 2007
Citation Information: J Clin Invest. 2007;117(10):3067-3074. https://doi.org/10.1172/JCI32380.
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Research Article Virology Article has an altmetric score of 1

Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection

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Abstract

HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of chronic viral infections but are not sufficient to control viral replication in HIV-1–positive subjects, and their function in HIV-2 infection is not fully established. In a community-based cohort of HIV-2 long-term nonprogressors in rural Guinea-Bissau, we performed what we believe is the first comprehensive analysis of HIV-2–specific immune responses. We demonstrate that Gag is the most immunogenic protein. The magnitude of the IFN-γ immune response to the HIV-2 proteome was inversely correlated with HIV-2 viremia, and this relationship was specifically due to the targeting of Gag. Furthermore, patients with undetectable viremia had greater Gag-specific responses compared with patients with high viral replication. The most frequently recognized peptides clustered within a defined region of Gag, and responses to a single peptide in this region were associated with low viral burden. The consistent relationship between Gag-specific immune responses and viremia control suggests that T cell responses are vital in determining the superior outcome of HIV-2 infection. A better understanding of how HIV-2 infection is controlled may identify correlates of effective protective immunity essential for the design of HIV vaccines.

Authors

Aleksandra Leligdowicz, Louis-Marie Yindom, Clayton Onyango, Ramu Sarge-Njie, Abraham Alabi, Matthew Cotten, Tim Vincent, Carlos da Costa, Peter Aaby, Assan Jaye, Tao Dong, Andrew McMichael, Hilton Whittle, Sarah Rowland-Jones

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Total citations by year

Year: 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 1 1 1 4 1 3 1 2 1 2 2 3 3 3 28
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Citations to this article (28)

Title and authors Publication Year
Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS
Boswell MT, Nazziwa J, Kuroki K, Palm A, Karlson S, Månsson F, Biague A, da Silva ZJ, Onyango CO, de Silva TI, Jaye A, Norrgren H, Medstrand P, Jansson M, Maenaka K, Rowland-Jones SL, Esbjörnsson J
Virus Evolution 2022
A high prevalence of potential HIV elite controllers identified over 30 years in Democratic Republic of Congo
MG Berg, A Olivo, BJ Harris, MA Rodgers, L James, S Mampunza, J Niles, F Baer, J Yamaguchi, L Kaptue, O Laeyendecker, TC Quinn, C McArthur, GA Cloherty
EBioMedicine 2021
HIV-2-Infected Macrophages Produce and Accumulate Poorly Infectious Viral Particles
E Gea-Mallorquí, L Zablocki-Thomas, M Maurin, M Jouve, V Rodrigues, N Ruffin, P Benaroch
Frontiers in microbiology 2020
Delayed disease progression in HIV-2: the importance of TRIM5α and the retroviral capsid: Interaction of TRIM5α and HIV-2 CA
MT Boswell, SL Rowland-Jones
Clinical & Experimental Immunology 2019
Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection
A Samri, C Charpentier, MS Diallo, M Bertine, S Even, V Morin, A Oudin, C Parizot, G Collin, A Hosmalin, R Cheynier, R Thiébaut, S Matheron, F Collin, R Zoorob, F Brun-Vézinet, B Autran, J Lifson
PLoS pathogens 2019
HIV-2 as a model to identify a functional HIV cure
J Esbjörnsson, M Jansson, S Jespersen, F Månsson, BL Hønge, J Lindman, C Medina, ZJ da Silva, H Norrgren, P Medstrand, SL Rowland-Jones, C Wejse
AIDS Research and Therapy 2019
Identification of Novel Respiratory Syncytial Virus CD4 + and CD8 + T Cell Epitopes in C57BL/6 Mice
ME Schmidt, SM Varga
ImmunoHorizons 2019
HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation:
TI de Silva, A Leligdowicz, J Carlson, M Garcia-Knight, C Onyango, N Miller, LM Yindom, S Hué, A Jaye, T Dong, M Cotten, SL Rowland-Jones
AIDS 2018
Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections:
SM Bächle, DF Malone, M Buggert, AC Karlsson, PE Isberg, AJ Biague, H Norrgren, P Medstrand, M Moll, JK Sandberg, M Jansson
AIDS 2016
Identification of Host Micro RNAs That Differentiate HIV-1 and HIV-2 Infection Using Genome Expression Profiling Techniques
K Devadas, S Biswas, M Haleyurgirisetty, V Ragupathy, X Wang, S Lee, I Hewlett
Viruses 2016
CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection:
M Buggert, J Frederiksen, O Lund, MR Betts, A Biague, M Nielsen, J Tauriainen, H Norrgren, P Medstrand, AC Karlsson, M Jansson
AIDS 2016
The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated: Antigen processing
S Jallow, A Leligdowicz, HB Kramer, C Onyango, M Cotten, C Wright, HC Whittle, A McMichael, T Dong, BM Kessler, SL Rowland-Jones
European Journal of Immunology 2015
Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection--The Pivotal Role of Immune Activation and T-cell Kinetics
A Hegedus, S Nyamweya, Y Zhang, S Govind, R Aspinall, A Mashanova, VA Jansen, H Whittle, A Jaye, KL Flanagan, DC Macallan
The Journal of Infectious Diseases 2014
HIV-1 and HIV-2 Differentially Mature Plasmacytoid Dendritic Cells into IFN-Producing Cells or APCs
CM Royle, DR Graham, S Sharma, D Fuchs, A Boasso
Journal of immunology (Baltimore, Md. : 1950) 2014
HIV-2 and its role in conglutinated approach towards Acquired Immunodeficiency Syndrome (AIDS) Vaccine Development
B Diwan, R Saxena, A Tiwari
SpringerPlus 2013
Clinical predictors cannot replace biological predictors in HIV-2 infection in a community setting in West Africa
AJ Gourlay, C Tienen, SS Dave, T Vincent, SL Rowland-Jones, JR Glynn, HC Whittle, MF van der Loeff
International Journal of Infectious Diseases 2012
Are Plasma Biomarkers of Immune Activation Predictive of HIV Progression: A Longitudinal Comparison and Analyses in HIV-1 and HIV-2 Infections?
S Nyamweya, J Townend, A Zaman, SJ Steele, D Jeffries, S Rowland-Jones, H Whittle, KL Flanagan, A Jaye
PloS one 2012
For Protection from HIV-1 Infection, More Might Not Be Better: a Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection
M Luo, CA Daniuk, TO Diallo, RE Capina, J Kimani, C Wachihi, M Kimani, T Bielawny, T Peterson, MG Mendoza, S Kiazyk, TB Ball, FA Plummer
Journal of virology 2011
Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes
TI de Silva, M Aasa-Chapman, M Cotten, S Hue, J Robinson, F Bibollet-Ruche, R Sarge-Njie, N Berry, A Jaye, P Aaby, H Whittle, S Rowland-Jones, R Weiss
Journal of virology 2011
Influence of HLA Class I and HLA-KIR Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa
LM Yindom, A Leligdowicz, MP Martin, X Gao, Y Qi, SM Zaman, MS van der Loeff, C van Tienen, A Jaye, A Aveika, A Worwui, M Diatta, T Vincent, HC Whittle, SL Rowland-Jones, R Walton, M Carrington
Journal of virology 2010
Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village
MF van der Loeff, N Larke, S Kaye, N Berry, K Ariyoshi, A Alabi, C van Tienen, A Leligdowicz, R Sarge-Njie, Z da Silva, A Jaye, D Ricard, T Vincent, SR Jones, P Aaby, S Jaffar, H Whittle
Retrovirology 2010
HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007
C van Tienen, MF van der Loeff, I Peterson, M Cotten, B Holmgren, S Andersson, T Vincent, R Sarge-Njie, S Rowland-Jones, A Jaye, P Aaby, H Whittle
Retrovirology 2010
Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?
A Boasso, GM Shearer, C Chougnet
Journal of Internal Medicine 2009
Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition
B Lohman-Payne, JA Slyker, BA Richardson, C Farquhar, M Majiwa, E Maleche-Obimbo, D Mbori-Ngacha, J Overbaugh, S Rowland-Jones, G John-Stewart
Clinical & Experimental Immunology 2009
Downregulation of the T-Cell Receptor by Human Immunodeficiency Virus Type 2 Nef Does Not Protect against Disease Progression
J Feldmann, A Leligdowicz, A Jaye, T Dong, H Whittle, SL Rowland-Jones
Journal of virology 2009
Special Anniversary Review: Twenty-five years of human immunodeficiency virus research: successes and challenges
RA Weiss
Clinical & Experimental Immunology 2008
Higher Homologous and Lower Cross-Reactive Gag-Specific T-Cell Responses in Human Immunodeficiency Virus Type 2 (HIV-2) Than in HIV-1 Infection
W Jennes, M Camara, T Dièye, S Mboup, L Kestens
Journal of virology 2008
Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1
RB Foxall, CS Cortesão, AS Albuquerque, RS Soares, RM Victorino, AE Sousa
Journal of virology 2008

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