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Citations to this article

Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction.
L Arbibe, … , C Wolf, L Touqui
L Arbibe, … , C Wolf, L Touqui
Published September 15, 1998
Citation Information: J Clin Invest. 1998;102(6):1152-1160. https://doi.org/10.1172/JCI3236.
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Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction.

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Abstract

Lyso-phospholipids exert a major injurious effect on lung cell membranes during Acute Respiratory Distress Syndrome (ARDS), but the mechanisms leading to their in vivo generation are still unknown. Intratracheal administration of LPS to guinea pigs induced the secretion of type II secretory phospholipase A2 (sPLA2-II) accompanied by a marked increase in fatty acid and lyso-phosphatidylcholine (lyso-PC) levels in the bronchoalveolar lavage fluid (BALF). Administration of LY311727, a specific sPLA2-II inhibitor, reduced by 60% the mass of free fatty acid and lyso-PC content in BALF. Gas chromatography/mass spectrometry analysis revealed that palmitic acid and palmitoyl-2-lyso-PC were the predominant lipid derivatives released in BALF. A similar pattern was observed after the intratracheal administration of recombinant guinea pig (r-GP) sPLA2-II and was accompanied by a 50-60% loss of surfactant phospholipid content, suggesting that surfactant is a major lung target of sPLA2-II. In confirmation, r-GP sPLA2-II was able to hydrolyze surfactant phospholipids in vitro. This hydrolysis was inhibited by surfactant protein A (SP-A) through a direct and selective protein-protein interaction between SP-A and sPLA2-II. Hence, our study reports an in vivo direct causal relationship between sPLA2-II and early surfactant degradation and a new process of regulation for sPLA2-II activity. Anti-sPLA2-II strategy may represent a novel therapeutic approach in lung injury, such as ARDS.

Authors

L Arbibe, K Koumanov, D Vial, C Rougeot, G Faure, N Havet, S Longacre, B B Vargaftig, G Béréziat, D R Voelker, C Wolf, L Touqui

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Ischemia–Reperfusion–induced Lung Injury
M Perrot, M Liu, TK Waddell, S Keshavjee
American journal of respiratory and critical care medicine 2003
Surfactant Protein-A and Phosphatidylglycerol Suppress Type IIA Phospholipase A2 Synthesis via Nuclear Factor-κB
YZ Wu, S Medjane, S Chabot, FS Kubrusly, I Raw, M Chignard, L Touqui
American journal of respiratory and critical care medicine 2003
A potent inhibitor of cytosolic phospholipase A 2 , arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
T Nagase, N Uozumi, T Aoki-Nagase, K Terawaki, S Ishii, T Tomita, H Yamamoto, K Hashizume, Y Ouchi, T Shimizu
American journal of physiology. Lung cellular and molecular physiology 2003
Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase
M Nanjundan, F Possmayer
American journal of physiology. Lung cellular and molecular physiology 2003
Surface activity of a synthetic lung surfactant containing a phospholipase-resistant phosphonolipid analog of dipalmitoyl phosphatidylcholine
Z Wang, AL Schwan, LL Lairson, JS O'Donnell, GF Byrne, A Foye, BA Holm, RH Notter
American journal of physiology. Lung cellular and molecular physiology 2003
Alterations in bronchoalveolar lavage fluid during ischemia-induced acute hepatic failure in the pig
G Kostopanagiotou
Hepatology 2003
Phospholipase A2 isoforms: a perspective
S Chakraborti
Cellular Signalling 2003
Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A2
E Boilard, SG Bourgoin, C Bernatchez, ME Surette
Blood 2003
Phospholipase A2 enzymes
I Kudo, M Murakami
Prostaglandins & Other Lipid Mediators 2002
Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2
K Hanasaki, H Arita
Prostaglandins & Other Lipid Mediators 2002
Identification of a Soluble Form Phospholipase A 2 Receptor as a Circulating Endogenous Inhibitor for Secretory Phospholipase A 2
K Higashino, Y Yokota, T Ono, S Kamitani, H Arita, K Hanasaki
The Journal of biological chemistry 2002
Effect of surfactant on pulmonary expression of type IIA PLA 2 in an animal model of acute lung injury
Y Wu, M Singer, F Thouron, M Alaoui-El-Azher, L Touqui
American journal of physiology. Lung cellular and molecular physiology 2002
Arachidonic Acid Differentially Affects Basal and Lipopolysaccharide-Induced sPLA 2 -IIA Expression in Alveolar Macrophages through NF-κB and PPAR-γ–Dependent Pathways
M Alaoui-El-Azher, Y Wu, N Havet, A Israël, A Lilienbaum, L Touqui
Molecular pharmacology 2002
The Influence of Lysophosphatidic Acid on the Functions of Human Dendritic Cells
E Panther, M Idzko, S Corinti, D Ferrari, Y Herouy, M Mockenhaupt, S Dichmann, P Gebicke-Haerter, FD Virgilio, G Girolomoni, J Norgauer
Journal of immunology (Baltimore, Md. : 1950) 2002
Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: Correlation with lung surfactant protection
S Furue, K Mikawa, K Nishina, M Shiga, M Ueno, Y Tomita, K Kuwabara, I Teshirogi, T Ono, Y Hori, A Matsukawa, M Yoshinaga, H Obara
Critical Care Medicine 2001
Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores
KC McCrae, T Rand, RA Shaw, C Mason, MR Oulton, C Hastings, T Cherlet, JA Thliveris, HH Mantsch, J MacDonald, JE Scott
Chemistry and Physics of Lipids 2001
Effect of methylprednisolone on phospholipase A2 activity and lung surfactant degradation in acute lung injury in rabbits
K Kuwabara, S Furue, Y Tomita, M Ueno, T Ono, A Matsukawa, M Yoshinaga, K Mikawa, K Nishina, M Shiga, H Obara, Y Hori
European Journal of Pharmacology 2001
Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study
AJ Schrama, AJ Beaufort, YR Sukul, SM Jansen, BJ Poorthuis, HM Berger
Acta Pdiatrica 2001
Meconium aspiration syndrome: a role for phospholipase A2 in the pathogenesis?
P Kääpä
Acta Pdiatrica 2001
Role of gut flora on intestinal group II phospholipase A 2 activity and intestinal injury in shock
RA Rozenfeld, X Liu, I Deplaen, W Hsueh
AJP Gastrointestinal and Liver Physiology 2001
Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages
MA el Azher, N Havet, M Singer, C Dumarey, L Touqui
European Journal of Biochemistry 2000
Pulmonary surfactant in innate immunity and the pathogenesis of tuberculosis
JS Ferguson, LS Schlesinger
Tubercle and Lung Disease 2000
Phospholipase A2 sécrétée de type IIA et syndrome inflammatoire
O Fourcade, MF Simon, FL Balle, J Fauvel, M Génestal, B Cathala, H Chap
Réanimation Urgences 2000
Polymer-Surfactant Treatment of Meconium-induced Acute Lung Injury
KW Lu, H William Taeusch, B Robertson, J Goerke, JA Clements
American journal of respiratory and critical care medicine 2000
Structures, Enzymatic Properties, and Expression of Novel Human and Mouse Secretory Phospholipase A 2 s
N Suzuki, J Ishizaki, Y Yokota, K Higashino, T Ono, M Ikeda, N Fujii, K Kawamoto, K Hanasaki
The Journal of biological chemistry 2000
Increasing molecular diversity of secreted phospholipases A2 and their receptors and binding proteins
E Valentin, G Lambeau
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2000
Secretory Phospholipase A 2 Receptor-Mediated Activation of Cytosolic Phospholipase A 2 in Murine Bone Marrow-Derived Mast Cells
AN Fonteh, G Atsumi, T LaPorte, FH Chilton
Journal of immunology (Baltimore, Md. : 1950) 2000
Survey of the 1998 optical biosensor literature
DG Myszka
Journal of Molecular Recognition 1999
Human Meconium Has High Phospholipase A2 Activity and Induces Cellular Injury and Apoptosis in Piglet Lungs
R Holopainen, H Aho, J Laine, H Peuravuori, H Soukka, P Kääpä
Pediatric Research 1999
A role for phospholipase A2 in ARDS pathogenesis
L Touqui, L Arbibe
Molecular Medicine Today 1999
Dioleylphosphatidylglycerol Inhibits the Expression of Type II Phospholipase A2 in Macrophages
A Berger, N Havet, D Vial, L Arbibe, C Dumarey, ML Watson, L Touqui
American journal of respiratory and critical care medicine 1999
Functional Association of Type IIA Secretory Phospholipase A 2 with the Glycosylphosphatidylinositol-anchored Heparan Sulfate Proteoglycan in the Cyclooxygenase-2-mediated Delayed Prostanoid-biosynthetic Pathway
M Murakami, T Kambe, S Shimbara, S Yamamoto, H Kuwata, I Kudo
The Journal of biological chemistry 1999

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