JCI - Citations to Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Annette Deichmann, … , Christof von Kalle, Marina Cavazzana-Calvo

Annette Deichmann, … , Christof von Kalle, Marina Cavazzana-Calvo

Published August 1, 2007
Citation Information: J Clin Invest. 2007;117(8):2225-2232. https://doi.org/10.1172/JCI31659.

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Identification of Hematopoietic Stem Cell Engraftment Genes in Gene Therapy Studies JM Powers, GD Trobridge	Journal of Stem Cell Research & Therapy	2013
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Transcriptional Enhancers Induce Insertional Gene Deregulation Independently From the Vector Type and Design G Maruggi, S Porcellini, G Facchini, SK Perna, C Cattoglio, D Sartori, A Ambrosi, A Schambach, C Baum, C Bonini, C Bovolenta, F Mavilio, A Recchia	Molecular Therapy	2009
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Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2locus K Yamada, T Tsukahara, K Yoshino, K Kojima, H Agawa, Y Yamashita, Y Amano, M Hatta, Y Matsuzaki, N Kurotori, K Wakui, Y Fukushima, R Osada, T Shiozawa, K Sakashita, K Koike, S Kumaki, N Tanaka, T Takeshita	Retrovirology	2009
High Incidence of Leukemia after Stem-Cell Gene Therapy in Large Animals with a HOXB4-expressing Vector Xiao-Bing Zhang, Brian C. Beard, Grant D. Trobridge, Brent L. Wood, George E. Sale, Reeteka Sud, R. Keith Humphries, Hans-Peter Kiem	Journal of Clinical Investigation	2008
Insertional Oncogenesis in Four Patients after Retrovirus-Mediated Gene Therapy of SCID-X1 Salima Hacein-Bey-Abina 1,2, Alexandrine Garrigue 2, Garry.P Wang 3, Jean Soulier 4, Annick Lim 5, Estelle Morillon 2, Emmanuelle Clappier 5, Laure Caccavelli 1, Eric Delabesse 6, Kheira Beldjord 7,8, Vahid Asnafi 7,8, Elizabeth MacIntyre7,8, Isabelle Radford 8, Nicole Brousse 9, François Sigaux4, Despina Moshous10, Julia Hauer 2, Arndt Borkhardt 11, Bernd.H Belohradsky 12, Uwe Wintergerst 12, Maria.C Velez 13, Lily Leiva13, Ricardo Sorensen 13, Nicolas Wulffraat 14, Stéphane Blanche 10, Frederic.D Bushman 3, Alain Fischer 2,10, Marina Cavazzana-Calvo 1,2	Journal of Clinical Investigation	2008
Insertional mutagenesis in combination with acquired somatic mutations leads to leukemogenesis following gene therapy of SCID-X1 Steven J Howe, Marc R Mansour, Kerstin Schwarzwaelder, Cynthia Bartholomae, Michael Hubank, Helena Kempski, Martijn H Brugman, Karin Pike-Overzet, Steven J Chatters, Dick de Ridder, Kimberly C Gilmour, Stuart Adams, Susannah I Thornhill, Kathryn L Parsley, Frank J.T. Staal, Rosemary E Gale, David C Linch, Jinhua Bayford, Lucie Brown, Michelle Quaye, Christine Kinnon, Philip Ancliff, David K Webb, Manfred Schmidt, Christof von Kalle, H Bobby Gaspar, Adrian J Thrasher	Journal of Clinical Investigation	2008
Stem Cell Marking With Promotor-deprived Self-inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance K Cornils, C Lange, A Schambach, MH Brugman, R Nowak, M Lioznov, C Baum, B Fehse	Molecular Therapy	2008
Neonatal intravenous injection of a gammaretroviral vector has a low incidence of tumor induction in mice M Tittiger, X Ma, L Xu, KP Ponder	Human Gene Therapy	2008
Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors J Hu, G Renaud, TJ Gomes, T Golmes, A Ferris, PC Hendrie, RE Donahue, SH Hughes, TG Wolfsberg, DW Russell, CE Dunbar	Molecular Therapy	2008
Recent advances in gene therapy for severe congenital immunodeficiency diseases R Sokolic, C Kesserwan, F Candotti	Current Opinion in Hematology	2008
Integration site selection by retroviral vectors: molecular mechanism and clinical consequences R Daniel, JA Smith	Human Gene Therapy	2008
Adeno-associated virus-mediated gene transfer A Srivastava	Journal of Cellular Biochemistry	2008
Potential genotoxicity from integration sites in CLAD dogs treated successfully with gammaretroviral vector-mediated gene therapy M Hai, RL Adler, TR Bauer, LM Tuschong, YC Gu, X Wu, DD Hickstein	Gene Therapy	2008
Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency SI Thornhill, A Schambach, SJ Howe, M Ulaganathan, E Grassman, D Williams, B Schiedlmeier, NJ Sebire, HB Gaspar, C Kinnon, C Baum, AJ Thrasher	Molecular Therapy	2008
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo Kerstin Schwarzwaelder, Steven J. Howe, Manfred Schmidt*, Martijn Brugman, Annette Deichmann, Hanno Glimm, Sonja Schmidt, Claudia Prinz, Manuela Wissler, Douglas J. S. King, Fang Zhang, Kathryn L. Parsley, Kimberly C. Gilmour, Joanna Sinclair, Jinhua Bayford, Rachel Peraj, Karin Pike-Overzet, Frank J. T. Staal, Dick de Ridder, Christine Kinnon, Ulrich Abel, Gerard Wagemaker, H. Bobby Gaspar, Adrian J. Thrasher and Christof von Kalle	Journal of Clinical Investigation	2007
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy Alessandro Aiuti, Barbara Cassani, Grazia Andolfi, Massimiliano Mirolo, Luca Biasco, Alessandra Recchia, Fabrizia Urbinati, Cristina Valacca, Samantha Scaramuzza, Memet Aker, Shimon Slavin, Matteo Cazzola, Daniela Sartori, Alessandro Ambrosi, Clelia Di Serio, Maria Grazia Roncarolo, Fulvio Mavilio, and Claudio Bordignon.	Journal of Clinical Investigation	2007
Retroviral integration and human gene therapy Frederic D. Bushman	Journal of Clinical Investigation	2007
Gene therapy for severe combined immunodeficiency: are we there yet? Marina Cavazzana-Calvo1,2 and Alain Fischer1,3	Journal of Clinical Investigation	2007

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