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Citations to this article

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
Isabelle M. Berquin, … , Jing X. Kang, Yong Q. Chen
Isabelle M. Berquin, … , Jing X. Kang, Yong Q. Chen
Published July 2, 2007
Citation Information: J Clin Invest. 2007;117(7):1866-1875. https://doi.org/10.1172/JCI31494.
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Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids

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Abstract

Although a causal role of genetic alterations in human cancer is well established, it is still unclear whether dietary fat can modulate cancer risk in a predisposed population. Epidemiological studies suggest that diets rich in omega-3 polyunsaturated fatty acids reduce cancer incidence. To determine the influence of fatty acids on prostate cancer risk in animals with a defined genetic lesion, we used prostate-specific Pten-knockout mice, an immune-competent, orthotopic prostate cancer model, and diets with defined polyunsaturated fatty acid levels. We found that omega-3 fatty acids reduced prostate tumor growth, slowed histopathological progression, and increased survival, whereas omega-6 fatty acids had opposite effects. Introducing an omega-3 desaturase, which converts omega-6 to omega-3 fatty acids, into the Pten-knockout mice reduced tumor growth similarly to the omega-3 diet. Tumors from mice on the omega-3 diet had lower proportions of phosphorylated Bad and higher apoptotic indexes compared with those from mice on omega-6 diet. Knockdown of Bad eliminated omega-3–induced cell death, and introduction of exogenous Bad restored the sensitivity to omega-3 fatty acids. Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer.

Authors

Isabelle M. Berquin, Younong Min, Ruping Wu, Jiansheng Wu, Donna Perry, J. Mark Cline, Mike J. Thomas, Todd Thornburg, George Kulik, Adrienne Smith, Iris J. Edwards, Ralph D’Agostino Jr., Hao Zhang, Hong Wu, Jing X. Kang, Yong Q. Chen

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
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Nature Reviews Urology 2010
Effect of Isocaloric Low Fat Diet on Prostate Cancer Xenograft Progression in a Hormone Deprivation Model
JC Lloyd, JA Antonelli, TE Phillips, EM Masko, JA Thomas, SH Poulton, M Pollack, SJ Freedland
The Journal of Urology 2010
Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
EC Cheon, MJ Strouch, MR Barron, Y Ding, LG Melstrom, SB Krantz, B Mullapudi, K Adrian, S Rao, TE Adrian, DJ Bentrem, PJ Grippo
International Journal of Cancer 2010
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP
S Kim, W Huang, EP Mottillo, A Sohail, YA Ham, MK Conley-LaComb, CJ Kim, G Tzivion, HR Kim, S Wang, YQ Chen, R Fridman
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2010
Transgenic Mice Enriched in Omega‐3 Fatty Acids Are More Susceptible to Pulmonary Tuberculosis: Impaired Resistance to Tuberculosis in fat‐1 Mice
DL Bonilla, YY Fan, RS Chapkin, DN McMurray
The Journal of Infectious Diseases 2010
Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer
Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ
Neoplasia (New York, N.Y.) 2010
Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten+/− preclinical mouse model
Vissapragada S, Ghosh A, Ringer L, Salinas P, Brophy A, Peaceman D, Kallakury B, Banerjee PP, Fricke ST, Helfrich W, Lee YC, Pestell R, Scherer P, Tanowitz HB, Avantaggiati ML, Hilakivi-Clarke L, Lisanti MP, Rodriguez OC, Albanese C
Cell cycle (Georgetown, Tex.) 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Are all n-3 polyunsaturated fatty acids created equal?
BM Anderson, DW Ma
Lipids in Health and Disease 2009
Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells
M Dimri, PV Bommi, AA Sahasrabuddhe, JD Khandekar, GP Dimri
Carcinogenesis 2009
Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer
AC Reese, V Fradet, JS Witte
Journal of Nutrigenetics and Nutrigenomics 2009
Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics
H Allayee, N Roth, HN Hodis
Journal of Nutrigenetics and Nutrigenomics 2009
A high omega-3 fatty acid diet mitigates murine pancreatic precancer development
MJ Strouch, Y Ding, MR Salabat, LG Melstrom, K Adrian, C Quinn, C Pelham, S Rao, TE Adrian, DJ Bentrem, PJ Grippo
The Journal of surgical research 2009
Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways
Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ
Neoplasia (New York, N.Y.) 2009
Omega-3 Fatty Acids and PPARgamma in Cancer
IJ Edwards, JT O'Flaherty
PPAR Research 2008
Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer
MF McEntee, C Ziegler, D Reel, K Tomer, A Shoieb, M Ray, X Li, N Neilsen, FB Lih, D O'Rourke, J Whelan
The American Journal of Pathology 2008
Multi-targeted therapy of cancer by omega-3 fatty acids
IM Berquin, IJ Edwards, YQ Chen
Cancer Letters 2008
In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids
IJ Edwards, H Sun, Y Hu, IM Berquin, JT O'Flaherty, JM Cline, LL Rudel, YQ Chen
The Journal of biological chemistry 2008
Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
C Otto, U Kaemmerer, B Illert, B Muehling, N Pfetzer, R Wittig, HU Voelker, A Thiede, JF Coy
BMC Cancer 2008
Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model
N Kobayashi, RJ Barnard, J Said, J Hong-Gonzalez, DM Corman, M Ku, NB Doan, D Gui, D Elashoff, P Cohen, WJ Aronson
Cancer research 2008
Fat-1 transgenic mice: a new model for omega-3 research
JX Kang
Prostaglandins, leukotrienes, and essential fatty acids 2007

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