After two-thirds hepatectomy, normally quiescent liver cells are stimulated to reenter the cell cycle and proliferate to restore the original liver mass. The level of bZIP transcription factor CCAAT enhancer-binding protein beta (C/EBPbeta) increases in the liver during the period of cell proliferation. The significance of this change in C/EBP expression is not understood. To determine the role of C/EBPbeta in the regenerating liver, we examined the regenerative response after partial hepatectomy in mice that contain a targeted disruption of the C/EBPbeta gene. Posthepatectomy, hepatocyte DNA synthesis was decreased to 25% of normal in C/EBPbeta -/- mice. The reduced regenerative response was associated with a prolonged period of hypoglycemia that was independent of expression of C/EBPalpha protein and gluconeogenic genes. C/EBPbeta -/- livers showed reduced expression of immediate-early growth-control genes including the Egr-1 transcription factor, mitogen-activated protein kinase protein tyrosine phosphatase (MKP-1), and HRS, a delayed-early gene that encodes an mRNA splicing protein. Cyclin B and E gene expression were dramatically reduced in C/EBPbeta -/- livers whereas cyclin D1 expression was normal. The abnormalities in immediate-early gene expression in C/EBPbeta -/- livers were distinct from those seen in IL-6 -/- livers. These data link C/EBPbeta to the activation of metabolic and growth response pathways in the regenerating liver and demonstrate that C/EBPbeta is required for a normal proliferative response.
L E Greenbaum, W Li, D E Cressman, Y Peng, G Ciliberto, V Poli, R Taub
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The Journal of biological chemistry | 2008 |
Estradiol induces type 8 17 -hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor and C/EBP
M Rotinen, J Celay, MM Alonso, A Arrazola, I Encio, J Villar |
Journal of Endocrinology | 2008 |
The identification of C/EBPβ as a transcription factor necessary for the induction of MAPK phosphatase-1 by toll-like receptor-4 ligand
IJ Cho, NR Woo, SG Kim |
Archives of Biochemistry and Biophysics | 2008 |
Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription
MM Thiaville, EE Dudenhausen, C Zhong, YX Pan, MS Kilberg |
Biochemical Journal | 2008 |
Alterations of Notch/Jagged mRNA and protein expression after partial hepatectomy in rats
HY Xu, BJ Li, RF Wang, R Andersson |
Scandinavian Journal of Gastroenterology | 2008 |
G9a-mediated Lysine Methylation Alters the Function of CCAAT/Enhancer-binding Protein-β
O Pless, E Kowenz-Leutz, M Knoblich, J Lausen, M Beyermann, MJ Walsh, A Leutz |
The Journal of biological chemistry | 2008 |
HDAC1 Promotes Liver Proliferation in Young Mice via Interactions with C/EBPβ
GL Wang, E Salisbury, X Shi, L Timchenko, EE Medrano, NA Timchenko |
The Journal of biological chemistry | 2008 |
CCAAT Enhancer-binding Protein α Is a Molecular Target of 1,25-Dihydroxyvitamin D 3 in MCF-7 Breast Cancer Cells
P Dhawan, R Weider, S Christakos |
The Journal of biological chemistry | 2008 |
FoxF1 and FoxL1 Link Hedgehog Signaling and the Control of Epithelial Proliferation in the Developing Stomach and Intestine
BB Madison, LB McKenna, D Dolson, DJ Epstein, KH Kaestner |
The Journal of biological chemistry | 2008 |
CCAAT/Enhancer Binding Protein-β Is a Transcriptional Regulator of Peroxisome-Proliferator-Activated Receptor-γ Coactivator-1α in the Regenerating Liver
H Wang, TH Peiris, A Mowery, JL Lay, Y Gao, LE Greenbaum |
Molecular Endocrinology | 2008 |
Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription
MM Thiaville, EE Dudenhausen, C Zhong, YX Pan, MS Kilberg |
Biochemical Journal | 2008 |
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery
A Moh, Y Iwamoto, GX Chai, SS Zhang, A Kano, DD Yang, W Zhang, J Wang, JJ Jacoby, B Gao, RA Flavell, XY Fu |
Laboratory Investigation | 2007 |
C/EBPδ regulates cell cycle and self-renewal of human limbal stem cells
V Barbaro, A Testa, ED Iorio, F Mavilio, G Pellegrini, MD Luca |
The Journal of Cell Biology | 2007 |
Restoration of Liver Mass after Injury Requires Proliferative and Not Embryonic Transcriptional Patterns
HH Otu, K Naxerova, K Ho, H Can, N Nesbitt, TA Libermann, SJ Karp |
The Journal of biological chemistry | 2007 |
C/EBPβ Activates E2F-regulated Genes in Vivo via Recruitment of the Coactivator CREB-binding Protein/P300
H Wang, B Larris, TH Peiris, L Zhang, JL Lay, Y Gao, LE Greenbaum |
The Journal of biological chemistry | 2007 |
An Intronic Locus Control Region Plays an Essential Role in the Establishment of an Autonomous Hepatic Chromatin Domain for the Human Vitamin D-Binding Protein Gene
T Hiroki, SA Liebhaber, NE Cooke |
Molecular and cellular biology | 2007 |
Molecular and functional validation of Anaplastic Lymphoma Kinase (ALK) signature: identification of CEBPB and BCL2A1 as critical target genes
Roberto Piva, Elisa Pellegrino, Michela Mattioli, Luca Agnelli, Luigia Lombardi, Francesco Boccalatte, Giulia Costa, Bruce A. Ruggeri, Mangeng Cheng, Roberto Chiarle, Giorgio Palestro, Antonino Neri, and Giorgio Inghirami |
Journal of Clinical Investigation | 2006 |
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection
EA Bard-Chapeau, J Yuan, N Droin, S Long, EE Zhang, TV Nguyen, GS Feng |
Molecular and cellular biology | 2006 |
Rosiglitazone inhibits mouse liver regeneration
YP Turmelle, O Shikapwashya, S Tu, PW Hruz, Q Yan, DA Rudnick |
The FASEB Journal | 2006 |
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
K Shanmukhappa, GE Sabla, JL Degen, JA Bezerra |
BMC Gastroenterology | 2006 |
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
E Stepniak, R Ricci, R Eferl, G Sumara, I Sumara, M Rath, L Hui, EF Wagner |
Genes & development | 2006 |
CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2
GY Suh, Y Jin, AK Yi, XM Wang, AM Choi |
American journal of respiratory cell and molecular biology | 2006 |
C/EBPbeta is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma
SR Mantena, A Kannan, YP Cheon, Q Li, PF Johnson, IC Bagchi, MK Bagchi |
Proceedings of the National Academy of Sciences | 2006 |
C/EBPβ is required for 'emergency' granulopoiesis
H Hirai, P Zhang, T Dayaram, CJ Hetherington, S Mizuno, J Imanishi, K Akashi, DG Tenen |
Nature Immunology | 2006 |
Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression
X Li, HY Huang, JG Chen, L Jiang, HL Liu, DG Liu, TJ Song, Q He, CG Ma, D Ma, HY Song, QQ Tang |
Biochemical and Biophysical Research Communications | 2006 |
Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis
S Yang, CK Leow, TM Tan |
World journal of gastroenterology : WJG | 2006 |
Blockage of oncostatin M-induced LDL receptor gene transcription by a dominant-negative mutant of C/EBPβ
Y Zhou, F Zhang, P Abidi, M Lin, G Thiel, J Liu |
Biochemical Journal | 2006 |
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha
RA DeAngelis, MM Markiewski, R Taub, JD Lambris |
Hepatology | 2005 |
A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism
CR Longo, VI Patel, GV Shrikhande, ST Scali, E Csizmadia, S Daniel, DW Sun, ST Grey, MB Arvelo, C Ferran |
Hepatology | 2005 |
Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice
K Shanmukhappa, R Mourya, GE Sabla, JL Degen, JA Bezerra |
Proceedings of the National Academy of Sciences | 2005 |
Inhibition of Albumin Synthesis in Chronic Diseases
M Chojkier |
Journal of Clinical Gastroenterology | 2005 |
Characterization of liver function in transdifferentiated hepatocytes
ZD Burke, CN Shen, KL Ralphs, D Tosh |
Journal of Cellular Physiology | 2005 |
C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence
T Sebastian, R Malik, S Thomas, J Sage, PF Johnson |
The EMBO Journal | 2005 |
Trimming the fat from liver regeneration
DA Rudnick |
Hepatology | 2005 |
Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPβ gene
K Isoda, H Koide, M Kojima, E Arita, M Ikkaku, S Higashiyama, F Tashiro, E Yamato, JI Miyazaki, M Kawase, K Yagi |
Biochemical and Biophysical Research Communications | 2005 |
The CAR nuclear receptor and hepatocyte proliferation
RH Costa, VV Kalinchenko, Y Tan, IC Wang |
Hepatology | 2005 |
Lack of therapeutic improvement of liver fibrosis in rats by dexamethasone in spite of ascites amelioration
SH Ki, DW Choi, CW Kim, SG Kim |
Chemico-Biological Interactions | 2005 |
Regulatory role of CCAAT/enhancer binding protein-β in the production of plasma proteins in yolk sac tumor
K Hirashiki, T Kishimoto, H Ishiguro, Y Nagai, M Furuya, S Sekiya, H Ishikura |
Experimental and Molecular Pathology | 2005 |
C/EBPβ contributes to hepatocyte growth factor-induced replication of rodent hepatocytes
B Wang, C Gao, KP Ponder |
Journal of Hepatology | 2005 |
Cell Cycle Defects Contribute to a Block in Hormone-induced Mammary Gland Proliferation in CCAAT/Enhancer-binding Protein (C/EBPβ)-null Mice
SL Grimm, A Contreras, MH Barcellos-Hoff, JM Rosen |
The Journal of biological chemistry | 2005 |
RNA CUG-binding Protein 1 Increases Translation of 20-kDa Isoform of CCAAT/Enhancer-binding Protein β by Interacting with the α and β Subunits of Eukaryotic Initiation Translation Factor 2
NA Timchenko, GL Wang, LT Timchenko |
The Journal of biological chemistry | 2005 |
Signaling Pathways in Liver Diseases
JF Dufour, PA Clavien, C Trautwein, R Graf |
2005 | |
C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells
L Bundy, S Wells, L Sealy |
Molecular Cancer | 2005 |
Transcriptional Networks in the Liver: Hepatocyte Nuclear Factor 6 Function Is Largely Independent of Foxa2
NE Rubins, JR Friedman, PP Le, L Zhang, J Brestelli, KH Kaestner |
Molecular and cellular biology | 2005 |
Met provides essential signals for liver regeneration
M Borowiak, AN Garratt, T Wüstefeld, M Strehle, C Trautwein, C Birchmeier |
Proceedings of the National Academy of Sciences | 2004 |
Liver regeneration: from myth to mechanism
R Taub |
Nature Reviews Molecular Cell Biology | 2004 |
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation
JR Friedman, B Larris, PP Le, TH Peiris, A Arsenlis, J Schug, JW Tobias, KH Kaestner, LE Greenbaum |
Proceedings of the National Academy of Sciences | 2004 |
C/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver
T Luedde, M Duderstadt, KL Streetz, F Tacke, S Kubicka, MP Manns, C Trautwein |
Hepatology | 2004 |
Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice
E Shteyer, Y Liao, LJ Muglia, PW Hruz, DA Rudnick |
Hepatology | 2004 |
Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction
KM Campbell, GE Sabla, JA Bezerra |
Journal of Hepatology | 2004 |
Role of MAPK Phosphatase-1 (MKP-1) in Adipocyte Differentiation
H Sakaue, W Ogawa, T Nakamura, T Mori, K Nakamura, M Kasuga |
The Journal of biological chemistry | 2004 |
Identification of Transcriptional Networks during Liver Regeneration
P White, JE Brestelli, KH Kaestner, LE Greenbaum |
The Journal of biological chemistry | 2004 |
Critical Prosurvival Roles for C/EBPβ and Insulin-Like Growth Factor I in Macrophage Tumor Cells
J Wessells, S Yakar, PF Johnson |
Molecular and cellular biology | 2004 |
Massive Hepatic Apoptosis After Fas Ligand Treatment in Insulin-Like Growth Factor Binding Protein-1 Deficient Mice Associated with Activated Matrix Metalloproteinase-9 and Transforming Growth Factor-b1
Julia I. Leu, Mary Ann S. Crissey, Rebecca Taub |
Journal of Clinical Investigation | 2003 |
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes
JW Zhang, QQ Tang, C Vinson, MD Lane |
Proceedings of the National Academy of Sciences | 2003 |
The proinflammatory mediators C3a and C5a are essential for liver regeneration
CW Strey, M Markiewski, D Mastellos, R Tudoran, LA Spruce, LE Greenbaum, JD Lambris |
Journal of Experimental Medicine | 2003 |
CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis
QQ Tang, TC Otto, MD Lane |
Proceedings of the National Academy of Sciences | 2003 |
Expression and DNA-binding activity of signal transducer and activator of transcription 3 in alcoholic cirrhosis compared to normal liver and primary biliary cirrhosis in humans
P Stärkel, K Bishop, Y Horsmans, AJ Strain |
The American Journal of Pathology | 2003 |
Liver regeneration
LG Koniaris, IH McKillop, SI Schwartz, TA Zimmers |
Journal of the American College of Surgeons | 2003 |
The molecular physiology of liver regeneration following partial hepatectomy
D Mangnall, NC Bird, AW Majeed |
Liver International | 2003 |
Entamoeba histolytica: expression and DNA binding of CCAAT/enhancer-binding proteins are regulated through the cell cycle
LA Marchat, M Pezet-Valdez, C López-Camarillo, E Orozco |
Experimental Parasitology | 2003 |
Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells
A Suzuki, A Iwama, H Miyashita, H Nakauchi, H Taniguchi |
Development (Cambridge, England) | 2003 |
Opposing Roles of C/EBPβ and AP-1 in the Control of Fibroblast Proliferation and Growth Arrest-specific Gene Expression
M Gagliardi, S Maynard, T Miyake, N Rodrigues, SL Tjew, E Cabannes, PA Bédard |
The Journal of biological chemistry | 2003 |
Hepatocyte growth factor activates CCAAT enhancer binding protein and cell replication via PI3-kinase pathway
M Cho |
Hepatology | 2003 |
Transcription factors in liver development, differentiation, and regeneration
RH Costa, VV Kalinichenko, AX Holterman, X Wang |
Hepatology | 2003 |
Signal transduction in the liver: C/EBPβ modulates cell proliferation and survival
M Buck |
Hepatology | 2003 |
Making the liver young again
S Mackey, P Singh, GJ Darlington |
Hepatology | 2003 |
Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation
JI Leu, MA Crissey, LE Craig, R Taub |
Molecular and cellular biology | 2003 |
The role of C/EBPbeta in mammary gland development and breast cancer.
Grimm SL, Rosen JM |
Journal of Mammary Gland Biology and Neoplasia | 2003 |
Nitric oxide in liver inflammation and regeneration
Paloma Martin-Sanz, Sonsoles Hortelano, Nuria A Callejas, Nora Goren, Marta Casado, Miriam Zeini, Lisardo Boscá |
Metabolic Brain Disease | 2002 |
CCAAT/enhancer-binding proteins: structure, function and regulation
DP Ramji, P Foka |
Biochemical Journal | 2002 |
Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response
MA Bird, PA Lange, LW Schrum, JW Grisham, RA Rippe, KE Behrns |
Surgery | 2002 |
CCAAT/enhancer binding proteins in normal mammary development and breast cancer
CA Zahnow |
Breast Cancer Research | 2002 |
Inhibited Activities in CCAAT/Enhancer-Binding Protein, Activating Protein-1 and Cyclins after Hepatectomy in Rats with Thioacetamide-Induced Liver Cirrhosis
G Zhao, K Nakano, K Chijiiwa, J Ueda, M Tanaka |
Biochemical and Biophysical Research Communications | 2002 |
New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypies
S Germeyer, A Birke, U Schmitt, N Dahmen, C Hiemke, U Havemann-Reinecke |
Brain Research | 2002 |
Hepatocytes and Endothelial Cells: Joining Forces to Conquer Development
JA Bezerra |
Pediatric Research | 2002 |
CCAAT/enhancer binding proteins in normal mammary development and breast cancer
CA Zahnow |
Breast Cancer Research | 2002 |
Regulation of CCAAT/Enhancer-binding Protein (C/EBP) Activator Proteins by Heterodimerization with C/EBPγ (Ig/EBP)
SE Parkin, M Baer, TD Copeland, RC Schwartz, PF Johnson |
The Journal of biological chemistry | 2002 |
STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration
W Li, X Liang, C Kellendonk, V Poli, R Taub |
The Journal of biological chemistry | 2002 |
Independent and overlapping transcriptional activation during liver development and regeneration in mice
N Kelley-Loughnane |
Hepatology | 2002 |
Delayed liver regeneration in peroxisome proliferator-activated receptor-α-null mice
S Anderson |
Hepatology | 2002 |
The mystery of liver regeneration
FG Court, SA Wemyss-Holden, AR Dennison, GJ Maddern |
The British journal of surgery | 2002 |
Impact of cell swelling on proliferative signal transduction in the liver
RD Kim, GS Stein, RS Chari |
Journal of Cellular Biochemistry | 2001 |
Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha
M Buck, L Zhang, NA Halasz, T Hunter, M Chojkier |
The EMBO Journal | 2001 |
Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
DA Rudnick, DH Perlmutter, LJ Muglia |
Proceedings of the National Academy of Sciences | 2001 |
After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2
P Stärkel, L Lambotte, C Sempoux, CD Saeger, A Saliez, D Maiter, Y Horsmans |
Gut | 2001 |
Plasminogen activators direct reorganization of the liver lobule after acute injury
JA Bezerra, AR Currier, H Melin-Aldana, G Sabla, TH Bugge, KW Kombrinck, JL Degen |
The American Journal of Pathology | 2001 |
Lower Activity of CCAAT/Enhancer-Binding Protein and Expression of Cyclin E, but Not Cyclin D1, Activating Protein-1 and p21WAF1, after Partial Hepatectomy in Obstructive Jaundice
K Nakano, K Chijiiwa, M Tanaka |
Biochemical and Biophysical Research Communications | 2001 |
Expression of CCAAT/Enhancer Binding Protein Family Genes in Monolayer and Sandwich Culture of Hepatocytes: Induction of Stress-Inducible GADD153
RC Wilkinson, AJ Dickson |
Biochemical and Biophysical Research Communications | 2001 |
Expression and function of CCAAT/enhancer binding protein? (C/EBP?) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells
LR Dearth, J Hutt, A Sattler, A Gigliotti, J DeWille |
Journal of Cellular Biochemistry | 2001 |
The chum salmon insulin-like growth factor II promoter requires Sp1 for its activation by C/EBPβ
AY Palamarchuk, VM Kavsan, JS Sussenbach, PE Holthuizen |
Molecular and Cellular Endocrinology | 2001 |
Expression and DNA-binding activity of C/EBPα and C/EBPβ in human liver and differentiated primary hepatocytes
JB Ferrini, E Rodrigues, V Dulic, L Pichard-Garcia, JM Fabre, P Blanc, P Maurel |
Journal of Hepatology | 2001 |
Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy
T Lüdde, S Kubicka, J Plümpe, C Liedtke, MP Manns, C Trautwein |
Oncogene | 2001 |
Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo
JC Tsai, L Liu, J Zhang, KC Spokes, JN Topper, WC Aird |
AJP Gastrointestinal and Liver Physiology | 2001 |
Regulated Nuclear-Cytoplasmic Localization of CCAAT/ Enhancer-binding Protein δ in Osteoblasts
J Billiard, Y Umayahara, K Wiren, M Centrella, TL McCarthy, P Rotwein |
The Journal of biological chemistry | 2001 |
Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells
T Mizuguchi, T Hui, K Palm, N Sugiyama, T Mitaka, AA Demetriou, J Rozga |
Journal of Cellular Physiology | 2001 |
Characterization of C/EBP? isoforms in normal versus neoplastic mammary epithelial cells
EM Eaton, M Hanlon, L Bundy, L Sealy |
Journal of Cellular Physiology | 2001 |
Liver regeneration: From laboratory to clinic
N Fausto |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2001 |
Compensatory hepatic regeneration after mild, but not fulminant, intraperitoneal sepsis in rats
YG Weiss, L Bellin, PK Kim, KM Andrejko, CA Haaxma, N Raj, EE Furth, CS Deutschman |
AJP Gastrointestinal and Liver Physiology | 2001 |
The constitutive activation of the CEF-4/9E3 chemokine gene depends on C/EBPβ in v-src transformed chicken embryo fibroblasts
M Gagliardi, S Maynard, B Bojovic, PA Bédard |
Oncogene | 2001 |
Contribution of cyclooxygenase‐2 to liver regeneration after partial hepatectomy
M Casado, NA Callejas, J Rodrigo, X Zhao, SK Dey, L Boscá, P MartínSanz |
The FASEB Journal | 2001 |
Cytokine-Responsive Gene-2/IFN-Inducible Protein-10 Expression in Multiple Models of Liver and Bile Duct Injury Suggests a Role in Tissue Regeneration
LG Koniaris, T Zimmers-Koniaris, EC Hsiao, K Chavin, JV Sitzmann, JM Farber |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Interleukin 6 and liver regeneration
KL Streetz, T Luedde, MP Manns, C Trautwein |
Gut | 2000 |
Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis
QQ Tang, MD Lane |
Proceedings of the National Academy of Sciences | 2000 |
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
K Kovalovich, RA DeAngelis, W Li, EE Furth, G Ciliberto, R Taub |
Hepatology | 2000 |
The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice
JC Tsai, L Liu, BC Cooley, MR DiChiara, JN Topper, WC Aird |
The FASEB Journal | 2000 |
Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins
NA Callejas, L Boscá, CS Williams, RN DuBois, P Martín-Sanz |
Gastroenterology | 2000 |
The Hepatocyte Review
MN Berry, AM Edwards |
2000 | |
Translational Induction of Liver-enriched Transcriptional Inhibitory Protein during Acute Phase Response Leads to Repression of CCAAT/Enhancer Binding Protein α mRNA
AL Welm, SL Mackey, LT Timchenko, GJ Darlington, NA Timchenko |
The Journal of biological chemistry | 2000 |
Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPβ gene
S Liu, C Croniger, C Arizmendi, M Harada-Shiba, J Ren, V Poli, RW Hanson, JE Friedman |
Journal of Clinical Investigation | 1999 |
Phosphorylation of Rat Serine 105 or Mouse Threonine 217 in C/EBPβ Is Required for Hepatocyte Proliferation Induced by TGFα
M Buck, V Poli, P der Geer, M Chojkier, T Hunter |
Molecular Cell | 1999 |
Cellular and molecular biology of the liver
SJ Karpen, JM Crawford |
Current Opinion in Gastroenterology | 1999 |
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
JA Bezerra, TH Bugge, H Melin-Aldana, G Sabla, KW Kombrinck, DP Witte, JL Degen |
Proceedings of the National Academy of Sciences | 1999 |
Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase
H Ye, AX Holterman, KW Yoo, RR Franks, RH Costa |
Molecular and cellular biology | 1999 |
Lipopolysaccharide potentiates the effect of hepatocyte growth factor on hepatocyte replication in rats by augmenting AP-1 activity
C Gao, R Jokerst, P Gondipalli, SR Cai, S Kennedy, MW Flye, KP Ponder |
Hepatology | 1999 |
Molecular mechanisms of liver development and differentiation
G Darlington |
Current Opinion in Cell Biology | 1999 |
The Relationship between Differentiation and Proliferation in Late Gestation Fetal Rat Hepatocytes
PA Gruppuso, TC Bienieki, RA Faris |
Pediatric Research | 1999 |
CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP mRNA and regulates translation of C/EBP isoforms
NA Timchenko, AL Lu, X Welm, LT Timchenko |
Nucleic Acids Research | 1999 |
Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
J Chen, G Kunos, B Gao |
FEBS Letters | 1999 |
CCAAT/Enhancer-binding Protein δ Is a Critical Regulator of Insulin-like Growth Factor-I Gene Transcription in Osteoblasts
Y Umayahara, J Billiard, C Ji, M Centrella, TL McCarthy, P Rotwein |
The Journal of biological chemistry | 1999 |
V. Knocking out genes to study liver regeneration: present and future
N Fausto |
AJP Gastrointestinal and Liver Physiology | 1999 |
C/EBPα Regulates Generation of C/EBPβ Isoforms through Activation of Specific Proteolytic Cleavage
AL Welm, NA Timchenko, GJ Darlington |
Molecular and cellular biology | 1999 |
Transcriptional Up-regulation of the Delayed Early Gene HRS/SRp40 during Liver Regeneration: INTERACTIONS AMONG YY1, GA-BINDING PROTEINS, AND MITOGENIC SIGNALS
K Du, JI Leu, Y Peng, R Taub |
The Journal of biological chemistry | 1998 |