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Citations to this article

Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease
Govind Bhagat, … , Peter H.R. Green, John S. Manavalan
Govind Bhagat, … , Peter H.R. Green, John S. Manavalan
Published December 6, 2007
Citation Information: J Clin Invest. 2008;118(1):281-293. https://doi.org/10.1172/JCI30989.
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Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease

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Abstract

Intraepithelial lymphocytes (IELs) bearing the γδ TCR are more abundant in the small intestinal mucosa of patients with celiac disease (CD) compared with healthy individuals. However, their role in disease pathogenesis is not well understood. Here, we investigated the functional attributes of TCRγδ+ IELs isolated from intestinal biopsies of patients with either active celiac disease (ACD) or those on a gluten-free diet (GFD). We found that compared with individuals with ACD, individuals on GFD have a higher frequency of CD8+TCRγδ+ IELs that express the inhibitory NK receptor NKG2A and intracellular TGF-β1. TCR triggering as well as cross-linking of NKG2A increased both TGF-β1 intracellular expression and secretion in vitro. Coculture of sorted TCRγδ+NKG2A+ IELs, IL-15–stimulated TCRαβ+ IELs, and HLA-E+ enterocytes resulted in a decreased percentage of cytotoxic CD8+TCRαβ+ IELs expressing intracellular IFN-γ and granzyme-B and surface NKG2D. This inhibition was partially abrogated by blocking either TGF-β alone or both NKG2A and HLA-E. Thus, our data indicate that suppression was at least partially mediated by TGF-β secretion as a result of engagement of NKG2A with its ligand, HLA-E, on enterocytes and/or TCRαβ+ IELs. These findings demonstrate that human small intestinal CD8+TCRγδ+ IELs may have regulatory potential in celiac disease.

Authors

Govind Bhagat, Afzal J. Naiyer, Jayesh G. Shah, Jason Harper, Bana Jabri, Timothy C. Wang, Peter H.R. Green, John S. Manavalan

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Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence
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A Han, EW Newell, J Glanville, N Fernandez-Becker, C Khosla, YH Chien, MM Davis
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T Katsurada, W Kobayashi, U Tomaru, T Baba, S Furukawa, A Ishizu, K Takeda, N Sakamoto, M Asaka, H Takeda, M Kasahara
PloS one 2012
Intraepithelial lymphocytes in celiac disease immunopathology
V Abadie, V Discepolo, B Jabri
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Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic
S Kalyan, D Kabelitz
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C Ma, Q Zhang, J Ye, F Wang, Y Zhang, E Wevers, T Schwartz, P Hunborg, MA Varvares, DF Hoft, EC Hsueh, G Peng
Journal of immunology (Baltimore, Md. : 1950) 2012
Dynamics of Non-conventional Intraepithelial Lymphocytes—NK, NKT, and γδ T—in Celiac Disease: Relationship with Age, Diet, and Histopathology
S Calleja, S Vivas, M Santiuste, L Arias, M Hernando, E Nistal, J Casqueiro, JG de Morales
Digestive Diseases and Sciences 2011
Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis
D Fujiwara, L Chen, B Wei, J Braun
AJP Gastrointestinal and Liver Physiology 2011
Immunomodulation at epithelial sites by obesity and metabolic disease
KP Cheung, KR Taylor, JM Jameson
Immunologic Research 2011
Regulation of immune cell function and differentiation by the NKG2D receptor
B Zafirova, FM Wensveen, M Gulin, B Polić
Cellular and Molecular Life Sciences 2011
The light and dark sides of intestinal intraepithelial lymphocytes
H Cheroutre, F Lambolez, D Mucida
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Z Li, C Zhang, Z Zhou, J Zhang, J Zhang, Z Tian, BA McCormick
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DD Nitto, I Monteleone, E Franzè, F Pallone, G Monteleone
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