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Citations to this article

Sickle cell disease: old discoveries, new concepts, and future promise
Paul S. Frenette, George F. Atweh
Paul S. Frenette, George F. Atweh
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):850-858. https://doi.org/10.1172/JCI30920.
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Sickle cell disease: old discoveries, new concepts, and future promise

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Abstract

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Authors

Paul S. Frenette, George F. Atweh

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 2 7 7 6 7 6 9 10 8 19 8 9 6 13 8 5 7 3 140
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Citations to this article (140)

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Journal of Clinical Investigation 2011
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FN Gavins, J Russell, EL Senchenkova, LD Paula, AS Damazo, CT Esmon, D Kirchhofer, RP Hebbel, DN Granger
Blood 2011
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
ER Macari, CH Lowrey
Blood 2011
Stress erythropoiesis: new signals and new stress progenitor cells
RF Paulson, L Shi, DC Wu
Current Opinion in Hematology 2011
Cellular Reprogramming toward the Erythroid Lineage
LJ Norton, AP Funnell, RC Pearson, M Crossley
International Journal of Cell Biology 2011
Membrane stability of sickle erythrocytes incubated in extracts of three medicinal plants: Anacardium occidentale, Psidium guajava, and Terminalia catappa
PC Chikezie, AA Uwakwe
Pharmacognosy magazine 2011
Minor Antigens on Transfused RBCs Crossprime CD8 T Cells but Do Not Induce Full Effector Function
M Desmarets, G Mylvaganam, EK Waller, CD Josephson, C Pack, AE Lukacher, JC Zimring
American Journal of Transplantation 2011
Perioperative Genomics
P Nagele
Best practice & research. Clinical anaesthesiology 2011
Neutrophil microdomains: linkingheterocellular interactions with vascular injury
C Scheiermann, Y Kunisaki, JE Jang, PS Frenette
Current Opinion in Hematology 2010
Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises
S Krishnan, Y Setty, SG Betal, V Vijender, K Rao, C Dampier, M Stuart
British Journal of Haematology 2010
The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports
R Jaeckel, M Thieme, E Czeslick, A Sablotzki
Journal of medical case reports 2010
Specific Binding of Red Blood Cells to Endothelial Cells Is Regulated by Nonadsorbing Macromolecules*
Y Yang, S Koo, CS Lin, B Neu
The Journal of biological chemistry 2010
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
J Chang, JT Patton, A Sarkar, B Ernst, JL Magnani, PS Frenette
Blood 2010
Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model
M Desmarets, CM Cadwell, KR Peterson, R Neades, JC Zimring
Blood 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
A Hidalgo, J Chang, JE Jang, AJ Peired, EY Chiang, PS Frenette
Nature Medicine 2009
Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease
H Fathallah, A Taher, A Bazarbachi, GF Atweh
Blood cells, molecules & diseases 2009
Genetics and the general physician: insights, applications and future challenges
JC Knight
QJM : monthly journal of the Association of Physicians 2009
Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia
N Bianchi, C Zuccato, I Lampronti, M Borgatti, R Gambari
Evidence-based complementary and alternative medicine : eCAM 2009
Disorder-to-order conformational transitions in protein structure and its relationship to disease
P Mendoza-Espinosa, V García-González, A Moreno, R Castillo, J Mas-Oliva
Molecular and Cellular Biochemistry 2009
Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion
J Chang, PA Shi, EY Chiang, PS Frenette
Blood 2008
Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia
S Sangkatumvong, TD Coates, MC Khoo
Physiological Measurement 2008
A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F
Z Chen, HY Luo, RK Basran, TH Hsu, DW Mang, L Nuntakarn, CG Rosenfield, GP Patrinos, RC Hardison, MH Steinberg, DH Chui
Molecular and cellular biology 2008

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