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Citations to this article

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
Shoji Sanada, … , Andrew N.J. McKenzie, Richard T. Lee
Shoji Sanada, … , Andrew N.J. McKenzie, Richard T. Lee
Published June 1, 2007
Citation Information: J Clin Invest. 2007;117(6):1538-1549. https://doi.org/10.1172/JCI30634.
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Research Article Cardiology Article has an altmetric score of 10

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

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Abstract

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels predict outcome in patients with acute myocardial infarction or chronic heart failure. Recently, IL-33 was identified as a functional ligand of ST2L, allowing exploration of the role of ST2 in myocardium. We found that IL-33 was a biomechanically induced protein predominantly synthesized by cardiac fibroblasts. IL-33 markedly antagonized angiotensin II– and phenylephrine-induced cardiomyocyte hypertrophy. Although IL-33 activated NF-κB, it inhibited angiotensin II– and phenylephrine-induced phosphorylation of inhibitor of NF-κBα (IκBα) and NF-κB nuclear binding activity. sST2 blocked antihypertrophic effects of IL-33, indicating that sST2 functions in myocardium as a soluble decoy receptor. Following pressure overload by transverse aortic constriction (TAC), ST2–/– mice had more left ventricular hypertrophy, more chamber dilation, reduced fractional shortening, more fibrosis, and impaired survival compared with WT littermates. Furthermore, recombinant IL-33 treatment reduced hypertrophy and fibrosis and improved survival after TAC in WT mice, but not in ST2–/– littermates. Thus, IL-33/ST2 signaling is a mechanically activated, cardioprotective fibroblast-cardiomyocyte paracrine system, which we believe to be novel. IL-33 may have therapeutic potential for beneficially regulating the myocardial response to overload.

Authors

Shoji Sanada, Daihiko Hakuno, Luke J. Higgins, Eric R. Schreiter, Andrew N.J. McKenzie, Richard T. Lee

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 8 29 35 35 36 43 33 28 25 26 25 19 30 22 14 14 8 11 441
Citation information
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Citations to this article in year 2016 (26)

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Biomarkers to Predict Reverse Remodeling and Myocardial Recovery in Heart Failure
SR Motiwala, HK Gaggin
Current Heart Failure Reports 2016
Cardiac‐Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers
CM Dewey, KM Spitler, JM Ponce, DD Hall, CE Grueter
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
TM Mohamed, R Abou-Leisa, N Stafford, A Maqsood, M Zi, S Prehar, F Baudoin-Stanley, X Wang, L Neyses, EJ Cartwright, D Oceandy
Nature Communications 2016
Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems
J Pellman, J Zhang, F Sheikh
Journal of Molecular and Cellular Cardiology 2016
Tissue Tregs
M Panduro, C Benoist, D Mathis
Annual Review of Immunology 2016
Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion InjuryNovelty and Significance
MC Woodall, BP Woodall, E Gao, A Yuan, WJ Koch
Circulation research 2016
Interleukin-33 in tumorigenesis, tumor immune evasion, and cancer immunotherapy
B Lu, M Yang, Q Wang
Journal of Molecular Medicine 2016
Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction
O Barbarash, O Gruzdeva, E Uchasova, Y Dyleva, E Belik, O Akbasheva, V Karetnikova, A Shilov
Annals of Laboratory Medicine 2016
Elevated circulating sST2 associated with subclinical atherosclerosis in newly diagnosed primary hypertension
I Ates, N Ozkayar, H Ates, UN Karakulak, O Kursun, C Topcuoglu, B Inan, N Yilmaz
Hypertension Research 2016
Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals:
KV Fitch, C DeFilippi, R Christenson, S Srinivasa, H Lee, J Lo, MT Lu, K Wong, E Petrow, L Sanchez, SE Looby, U Hoffmann, M Zanni, SK Grinspoon
AIDS 2016
Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study
C Andersson, D Enserro, L Sullivan, TJ Wang, JL Januzzi, EJ Benjamin, JA Vita, NM Hamburg, MG Larson, GF Mitchell, RS Vasan
Atherosclerosis 2016
Interleukin-33 in health and disease
FY Liew, JP Girard, HR Turnquist
Nature Reviews Immunology 2016
Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity
Q Liu, HR Turnquist
Current Opinion in Organ Transplantation 2016
Interleukin 33 is a guardian of barriers and a local alarmin
NT Martin, MU Martin
Nature Immunology 2016
Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells
W Kuswanto, D Burzyn, M Panduro, KK Wang, YC Jang, AJ Wagers, C Benoist, D Mathis
Immunity 2016
Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure
DH Huang, H Sun, JP Shi
Chinese Medical Journal 2016
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development
Z Su, P Zhang, Y Yu, H Lu, Y Liu, P Ni, X Su, D Wang, Y Liu, J Wang, H Shen, W Xu, H Xu
Scientific Reports 2016
Soluble ST2 for Prediction of Heart Failure and Cardiovascular Death in an Elderly, Community‐Dwelling Population
RH Parikh, SL Seliger, R Christenson, JS Gottdiener, BM Psaty, CR deFilippi
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy
KC Woulfe, AK Siomos, H Nguyen, M SooHoo, C Galambos, BL Stauffer, C Sucharov, S Miyamoto
Journal of Cardiac Failure 2016
Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach
Y Zhu, Y Lin, W Yan, Z Sun, Z Jiang, B Shen, X Jiang, J Shi
BioMed Research International 2016
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
J Yang, K Savvatis, JS Kang, P Fan, H Zhong, K Schwartz, V Barry, A Mikels-Vigdal, S Karpinski, D Kornyeyev, J Adamkewicz, X Feng, Q Zhou, C Shang, P Kumar, D Phan, M Kasner, B López, J Diez, KC Wright, RL Kovacs, PS Chen, T Quertermous, V Smith, L Yao, C Tschöpe, CP Chang
Nature Communications 2016
Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
Z Zhang, H Wang, L Zhang, R Crew, N Zhang, X Liu, Y Jiang
Journal of Immunology Research 2016
Soluble ST2 and Risk of Arrhythmias, Heart Failure, or Death in Patients with Mildly Symptomatic Heart Failure: Results from MADIT-CRT
H Skali, R Gerwien, TE Meyer, JV Snider, SD Solomon, CM Stolen
Journal of Cardiovascular Translational Research 2016
Associations of proteins relevant to MAPK signaling pathway (p38MAPK-1,HIF-1 and HO-1) with coronary lesion characteristics and prognosis of peri-menopausal women
L Yan, X Cao, S Zeng, Z Li, Z Lian, J Wang, F Lv, Y Wang, Y Li
Lipids in Health and Disease 2016
Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
N Pejnovic, I Jeftic, N Jovicic, N Arsenijevic, ML Lukic
World journal of gastroenterology : WJG 2016
Left Ventricular Remodelling: A Problem in Search of Solutions
DV Cokkinos, C Belogianneas
European Cardiology Review 2016

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