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The role of CXC chemokines in pulmonary fibrosis
Robert M. Strieter, … , Brigitte N. Gomperts, Michael P. Keane
Robert M. Strieter, … , Brigitte N. Gomperts, Michael P. Keane
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):549-556. https://doi.org/10.1172/JCI30562.
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Review Series Article has an altmetric score of 9

The role of CXC chemokines in pulmonary fibrosis

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Abstract

The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.

Authors

Robert M. Strieter, Brigitte N. Gomperts, Michael P. Keane

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Figure 4

The role of the CXCL12-CXCR4 biological axis in fibrocyte extravasation in pulmonary fibrosis.

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The role of the CXCL12-CXCR4 biological axis in fibrocyte extravasation ...
Lung-derived factors (such as GM-CSF, G-CSF, and M-CSF) generated under conditions of lung injury communicate with the BM to expand the number of fibrocytes in the BM and to mobilize fibrocytes that express CXCR4 into the circulation. CXCR4-expressing fibrocytes traffic through the circulation and extravasate into the lung in response to the CXCR4 ligand CXCL12, which is produced during the pathogenesis of fibrosis.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 5 patents
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