Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
John P. Iredale
John P. Iredale
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):539-548. https://doi.org/10.1172/JCI30542.
View: Text | PDF
Review Series Article has an altmetric score of 9

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

  • Text
  • PDF
Abstract

Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.

Authors

John P. Iredale

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 1976 Total
Citations: 7 27 25 17 25 19 17 24 20 29 27 26 25 24 22 18 18 16 1 1 388
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (388)

Title and authors Publication Year
Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells
Wang Z, Yuan M, Yao L, Xiong Z, Dai K, Liu P, Chen P, Sun M, Shu K, Xia Y, Jiang Y
Journal of Nanobiotechnology 2025
Study on the mechanism of hsa_circ_0074763 regulating the miR-3667-3P/ACSL4 axis in liver fibrosis
Cheng Y, Song T, Yao J, Wang Q, Meng C, Feng F
Scientific Reports 2025
cPLA2α on the influence of Th17 and its role in the formation of liver fibrosis
Ma L, Wang W, Gu L, Wang L
Cytotechnology 2025
Towards novel liver injury therapies based on design, synthesis and therapeutic efficacy of novel sulfone bis-compound on liver necrosis
Rashdan HR, Hassan S, Maher S, Okasha H
Scientific Reports 2025
The Wnt/β-Catenin Inhibitor HC-1 Suppresses Liver Fibrosis by Inhibiting Activated Hepatic Stellate Cells and Inducing Matrix Metalloproteinase-1
Hatakeyama D, Itaba N, Shimizu H, Morimoto M, Shiota G
Yonago Acta Medica 2025
Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis
Zhang C, Ma H, DeRoche D, Gale EM, Pantazopoulos P, Rotile NJ, Diyabalanage H, Humblet V, Caravan P, Zhou IY
npj Imaging 2025
Identification and validation of the fibrosis-related molecular subtypes of hepatocellular carcinoma by bioinformatics
Liu LL, Cao WL, Chen JS, Wang JP
Discover Oncology 2025
Artificial Intelligence in Liver Diseases: Recent Advances.
Lu F, Meng Y, Song X, Li X, Liu Z, Gu C, Zheng X, Jing Y, Cai W, Pinyopornpanish K, Mancuso A, Romeiro FG, Méndez-Sánchez N, Qi X
Advances in Therapy 2024
A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation
Atia MM, Mahmoud HA, Wilson M, Abd-Allah EA
Heliyon 2024
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities.
Diwan R, Gaytan SL, Bhatt HN, Pena-Zacarias J, Nurunnabi M
Drug Delivery and Translational Research 2024
Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system
Zhao BW, Chen YJ, Zhang RP, Chen YM, Huang BW
World Journal of Gastroenterology 2024
Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis.
Li D, Yang W, Pang J, Yu G
Molecular Biology Reports 2024
Radiofrequency ablation versus microwave ablation for hepatocellular carcinoma with cirrhosis: a propensity score analysis
Xiong Y, Zhang Y, Hu C
Translational cancer research 2024
Exportin 4 DNA promoter methylation in liver fibrosis
Pan Z, Bayoumi A, Metwally M, George J, Eslam M
PloS one 2024
Assessing the combined impact of fatty liver-induced TGF-β1 and LPS-activated macrophages in fibrosis through a novel 3D serial section methodology
Ishiyama S, Hayatsu M, Toriumi T, Tsuda H, Watanabe K, Kasai H, Kishigami S, Mochizuki K, Mikami Y
Scientific Reports 2024
Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis: Should we consider further implications?
Barone M
World Journal of Gastroenterology 2024
Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles
Elmorsy EA, Saber S, Kira AY, Alghasham A, Abdel-Hamed MR, Amer MM, Mohamed EA, AlSalloom A. A, Alkhamiss AS, Hamad RS, Abdel-Reheim MA, Ellethy AT, Elsisi HA, Alsharidah M, Elghandour SR, Elnawawy T, Abdelhady R
Frontiers in pharmacology 2024
Boiling histotripsy exhibits anti-fibrotic effects in animal models of liver fibrosis
Joung C, Heo J, Pahk KJ, Pahk K
Scientific Reports 2024
Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells
Chen L, Ye X, Yang L, Zhao J, You J, Feng Y
2024
Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells
Akkız H, Gieseler RK, Canbay A
International journal of molecular sciences 2024
Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations
Liu Q, Wang S, Fu J, Chen Y, Xu J, Wei W, Song H, Zhao X, Wang H
Clinical and Translational Medicine 2024
New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?
Tagliaferro M, Marino M, Basile V, Pocino K, Rapaccini GL, Ciasca G, Basile U, Carnazzo V
Journal of Personalized Medicine 2024
Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis
Setyawati DR, Sekaringtyas FC, Pratiwi RD, Rosyidah A, Azhar R, Gustini N, Syahputra G, Rosidah I, Mardliyati E, Tarwadi, El Muttaqien S
Beilstein Journal of Nanotechnology 2024
Potential mechanisms of traditional Chinese medicine in the treatment of liver cirrhosis: a focus on gut microbiota
Sun S, Zhang G, Lv S, Sun J
Frontiers in Microbiology 2024
Exploring hepatic fibrosis screening via deep learning analysis of tongue images
Lu XZ, Hu HT, Li W, Deng JF, Chen LD, Cheng MQ, Huang H, Ke WP, Wang W, Sun BG
Journal of Traditional and Complementary Medicine 2024
Wharton's Jelly mesenchymal stem cell‐derived extracellular vesicles induce liver fibrosis‐resolving phenotype in alternatively activated macrophages
Torabi S, Zarrabi M, Shekari F, Poorkazem H, Lotfinia M, Bencina S, Gramignoli R, Hassan M, Najimi M, Vosough M
Journal of Cellular and Molecular Medicine 2024
Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism.
Li X, Liu Y, Tang Y, Xia Z
Frontiers in immunology 2024
Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders
Selc M, Macova R, Babelova A
Drug Design, Development and Therapy 2024
Clinical implications of the latest advances in gastrointestinal tumor research
Dai W, Li YQ, Zhou Y
World Journal of Gastrointestinal Oncology 2024
Mechanisms of Metal-Induced Hepatic Inflammation.
Subramaniam NK, Mann KK
Current environmental health reports 2024
Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis
Zhang C, Ma H, DeRoche D, Gale EM, Pantazopoulos P, Rotile NJ, Diyabalanage H, Humblet V, Caravan P, Zhou IY
Research Square 2024
Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard
Charoenchue P, Khorana J, Chitapanarux T, Inmutto N, Na Chiangmai W, Amantakul A, Pojchamarnwiputh S, Tantraworasin A
Diagnostics 2024
Unveiling the role of Pafah1b3 in liver fibrosis: A novel mechanism revealed
Lin L, Yang S, Li X, Zhang W, Zheng J
Journal of Pharmaceutical Analysis 2024
m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs
Dai X, Cheng Y, Luo W, Wang J, Wang C, Zhang X, Zhang W, Chao J
Small Science 2024
Neuroblastoma RAS viral oncogene homolog (N-RAS) exerts a cytoprotective effect in liver injury
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José Regueiro, Eduardo Martínez-Naves, Mohamed Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Gines, Andreea Ciudin, Jesús Rivera-Esteban, Juan Pericàs, María Frutos, Bruno Molina, José Herranz, Matías Ávila, Yulia Nevzorova, Edgar Fernández-Malavé, Francisco Cubero
Cell Death and Disease 2023
Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis
Li L, Zhu Z
Frontiers in pharmacology 2023
Identification of key genes related to immune infiltration in cirrhosis via bioinformatics analysis
Du TY, Gao YX, Zheng YS
Scientific Reports 2023
Liver immunity, autoimmunity, and inborn errors of immunity
Parlar YE, Ayar SN, Cagdas D, Balaban YH
World journal of hepatology 2023
Influence of ursodeoxycholic acid on blood glucose, insulin and GLP-1 in rats with liver fibrosis induced by bile duct ligation
Bai XP, Du WJ, Xing HB, Yang GH, Bai R
Diabetology & metabolic syndrome 2023
A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis in rats via AGE-RAGE-ROS signaling.
Abouelezz HM, Shehatou GSG, Shebl AM, Salem HA
Heliyon 2023
Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells
Lin CY, Mamani UF, Guo Y, Liu Y, Cheng K
Biomolecules 2023
DHEA and Its Metabolites Reduce the Cytokines Involved in the Inflammatory Response and Fibrosis in Primary Biliary Cholangitis
Blatkiewicz M, Sielatycka K, Piotrowska K, Kilańczyk E
International journal of molecular sciences 2023
Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics
Singh S, Sharma N, Shukla S, Behl T, Gupta S, Anwer MK, Vargas-De-La-Cruz C, Bungau SG, Brisc C
Molecules (Basel, Switzerland) 2023
The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats
Wu Z, Wu Y, Zhong W, Zhong Q, Rao S, Yu D, Luo X, Qiu F, Song Z, Jin D, Ai M, Lan Y, Zhang G, Song S, Xie B, Sun S
Experimental and therapeutic medicine 2023
Can Vitamin D Levels Alter the Effectiveness of Short-Term Facelift Interventions?
Trifan DF, Tirla AG, Moldovan AF, Moș C, Bodog F, Maghiar TT, Manole F, Ghitea TC
Healthcare 2023
Hepatic inflammatory responses in liver fibrosis.
Hammerich L, Tacke F
Nature reviews. Gastroenterology & hepatology 2023
Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis
Ha KB, Lee ES, Park NW, Jo SH, Shim S, Kim DK, Ahn CM, Chung CH
Diabetes & Metabolism Journal 2023
Friend or foe? The elusive role of hepatic stellate cells in liver cancer.
Cogliati B, Yashaswini CN, Wang S, Sia D, Friedman SL
Nature reviews. Gastroenterology & hepatology 2023
In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations.
Lee YS, Seki E
Cellular and Molecular Gastroenterology and Hepatology 2023
Correlation between SDF-1α, CD34 positive hematopoietic stem cells and CXCR4 expression with liver fibrosis in CCl4 rat model.
Abubakr S, Hazem NM, Sherif RN, Elhawary AA, Botros KG
BMC Gastroenterology 2023
Isolation and Biological Evaluation of Alfa-Mangostin as Potential Therapeutic Agents against Liver Fibrosis
Liao YJ, Lee CY, Twu YC, Suk FM, Lai TC, Chang YC, Lai YC, Yuan JW, Jhuang HM, Jian HR, Huang LC, Chen KP, Hsu MH
Bioengineering 2023
Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
Hijazi N, Shi Z, Rockey DC
Journal of cell science 2023
Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions
Myint M, Oppedisano F, De Giorgi V, Kim BM, Marincola FM, Alter HJ, Nesci S
Journal of Translational Medicine 2023
Suppressed Histone H3 Lysine 18 Acetylation Is Involved in Arsenic-Induced Liver Fibrosis in Rats by Triggering the Dedifferentiation of Liver Sinusoidal Endothelial Cells
Hu F, Zhou X, Peng Q, Ma L
Toxics 2023
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation
Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang W, Brashear W, Dai Y, Li S, Sun Y, Qi Y, Guo S
Cellular and Molecular Gastroenterology and Hepatology 2023
The Origin and Fate of Liver Myofibroblasts
Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T
Cellular and Molecular Gastroenterology and Hepatology 2023
Antifibrotic Effect of Selenium-Containing Nanoparticles on a Model of TAA-Induced Liver Fibrosis
Varlamova EG, Goltyaev MV, Rogachev VV, Gudkov SV, Karaduleva EV, Turovsky EA
Cells 2023
Programmed cell death in hepatic fibrosis: current and perspectives.
Lu JL, Yu CX, Song LJ
Cell Death Discovery 2023
The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration.
Deshmukh K, Apte U
Seminars in liver disease 2023
Gut Microbiome and Organ Fibrosis
C Costa, B Sampaio-Maia, R Araujo, D Nascimento, J Ferreira-Gomes, M Pestana, M Azevedo, I Alencastre
Nutrients 2022
Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora.
Liu X, Wang L, Tan S, Chen Z, Wu B, Wu X
Frontiers in pharmacology 2022
Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.
Islam R, Kundu S, Jha SB, Rivera AP, Flores Monar GV, Islam H, Puttagunta SM, Sange I
Cureus 2022
Mouse Models of Liver Parenchyma Injuries and Regeneration
Du Y, Zhang W, Qiu H, Xiao C, Shi J, Reid LM, He Z
Frontiers in Cell and Developmental Biology 2022
Quantitative ultrasound, elastography, and machine learning for assessment of steatosis, inflammation, and fibrosis in chronic liver disease
Destrempes F, Gesnik M, Chayer B, Roy-Cardinal MH, Olivié D, Giard JM, Sebastiani G, Nguyen BN, Cloutier G, Tang A
PloS one 2022
The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data
Chen S, Cai X, Liu Y, Shen Y, Guillot A, Tacke F, Tang L, Liu H
Bioengineered 2022
Treatment of Liver Fibrosis: A 20-Year Bibliometric and Knowledge-Map Analysis
Dai YK, Zhao ZM, Liu C
Frontiers in pharmacology 2022
Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease.
He X, Liu T, Zhang R, Li X
Genetics Research 2022
Comparison of spin-echo echo-planar imaging magnetic resonance elastography with gradient-recalled echo magnetic resonance elastography and their correlation with transient elastography.
Yoon JW, Lee ES, Park HJ, Park SB, Cho YY, Kannengiesser S, Hur J
2022
Anti-liver fibrosis activity of curcumin/chitosan-coated green silver nanoparticles.
Elzoheiry A, Ayad E, Omar N, Elbakry K, Hyder A
Scientific Reports 2022
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022
Current Perspectives of Neuroendocrine Regulation in Liver Fibrosis
Li B, Wang H, Zhang Y, Liu Y, Zhou T, Zhou B, Zhang Y, Chen R, Xing J, He L, Salinas JM, Koyama S, Meng F, Wan Y
Cells 2022
Insights into Manganese Superoxide Dismutase and Human Diseases
Liu M, Sun X, Chen B, Dai R, Xi Z, Xu H
International journal of molecular sciences 2022
Novel potential biomarkers for severe alcoholic liver disease
Huang J, Yu J, Wang J, Liu J, Xie W, Li R, Wang C
Frontiers in immunology 2022
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment
Ning Y, Zhou IY, Roberts JD Jr, Rotile NJ, Akam E, Barrett SC, Sojoodi M, Barr MN, Punshon T, Pantazopoulos P, Drescher HK, Jackson BP, Tanabe KK, Caravan P
Science Translational Medicine 2022
Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy.
Li H, Liu T, Yang Y, Cho WC, Flynn RJ, Harandi MF, Song H, Luo X, Zheng Y
Genes & Diseases 2022
Differential recruitment of monocyte-derived macrophages in control and stellate cell-depleted mice during recurrent carbon tetrachloride-induced acute liver injury.
Sharma A, Kudira R, Wang J, Miethke A, Gandhi CR
Journal of Cellular Physiology 2022
Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations
D Heinrichs, EF Brandt, P Fischer, J Köhncke, TH Wirtz, N Guldiken, S Djudjaj, P Boor, D Kroy, R Weiskirchen, R Bucala, HE Wasmuth, P Strnad, C Trautwein, J Bernhagen, ML Berres
Cells 2021
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Y Wu, Y Cao, K Xu, Y Zhu, Y Qiao, Y Wu, J Chen, C Li, R Zeng, G Ge
Cell Death and Disease 2021
Liver regeneration and inflammation: from fundamental science to clinical applications
L Campana, H Esser, M Huch, S Forbes
Nature Reviews Molecular Cell Biology 2021
HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
X Xie, H Lv, C Liu, X Su, Z Yu, S Song, H Bian, M Tian, C Qin, J Qi, Q Zhu
BMC Medicine 2021
Anti-fibrotic treatments for chronic liver diseases: The present and the future
N Odagiri, T Matsubara, M Sato-Matsubara, H Fujii, M Enomoto, N Kawada
Clinical and Molecular Hepatology 2021
Natural Progression of Non-Alcoholic Steatohepatitis to Hepatocellular Carcinoma
D Ramai, W Tai, M Rivera, A Facciorusso, N Tartaglia, M Pacilli, A Ambrosi, C Cotsoglou, R Sacco
Biomedicines 2021
Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration
F Arnold, PU Mahaddalkar, JM Kraus, X Zhong, W Bergmann, D Srinivasan, J Gout, E Roger, AK Beutel, E Zizer, U Tharehalli, N Daiss, R Russell, L Perkhofer, R Oellinger, Q Lin, N Azoitei, FU Weiss, MM Lerch, S Liebau, SF Katz, A Lechel, R Rad, T Seufferlein, HA Kestler, M Ott, AD Sharma, PC Hermann, A Kleger
Advanced Science 2021
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol‐associated liver disease
J Chen, R MartinMateos, J Li, Z Yin, J Chen, X Lu, KJ Glaser, T Mounajjed, H Yashiro, J Siegelman, CT Winkelmann, J Wang, RL Ehman, VH Shah, M Yin
Alcoholism, clinical and experimental research 2021
Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis
AE Fearon, CF Slabber, A Kuklin, M Bachofner, L Tortola, L Pohlmeier, S Pantasis, T Hornemann, L Chen, M Kopf, S Werner
iScience 2021
Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways
Z Li, Z Wang, F Dong, W Shi, W Dai, J Zhao, Q Li, Z Fang, L Ren, T Liu, Z Wei, W Mou, L Lin, Y Yang, X Xiao, L Ma, Z Bai
Frontiers in pharmacology 2021
Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis
JH Yoon, JM Lee, MH Yu, BY Hur, R Grimm, S Sourbron, H Chandarana, Y Son, S Basak, KB Lee, NJ Yi, KW Lee, KS Suh
European Radiology 2021
Patterns of dendritic cell and monocyte subsets are associated with disease severity and mortality in liver cirrhosis patients
CC Cardoso, C Matiollo, CH Pereira, JS Fonseca, HE Alves, OM da Silva, V de Souza Menegassi, CR dos Santos, AC de Moraes, L de Lucca Schiavon, MC Santos-Silva
Scientific Reports 2021
Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
P Mukherjee, A Miyazawa, S Fukuda, T Yamashita, D Lukmanto, K Okada, IA El-Sadek, L Zhu, S Makita, T Oshika, Y Yasuno
Scientific Reports 2021
Efficacy and Safety of Emricasan in Liver Cirrhosis and/or Fibrosis
L Mu, S Li, L Tang, R Li
Clinics 2021
Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice
F Momen-Heravi, D Catalano, A Talis, G Szabo, S Bala
Molecular Therapy — Nucleic Acids 2021
Modulation of Liver Inflammation and Fibrosis by Interleukin-37
S Mountford, M Effenberger, H Noll-Puchta, L Griessmair, A Ringleb, S Haas, G Denk, FP Reiter, D Mayr, CA Dinarello, H Tilg, P Bufler
Frontiers in immunology 2021
Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs
S Fumoto, T Yamamoto, K Okami, Y Maemura, C Terada, A Yamayoshi, K Nishida
Pharmaceutics 2021
Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor
FK El-Baz, A Salama, SI Ali, R Elgohary, AM Attar
BioMed Research International 2021
Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis
S Pu, Y Li, Q Liu, X Zhang, L Chen, R Li, J Zhang, T Wu, Q Tang, X Yang, Z Zhang, Y Huang, J Kuang, H Li, M Zou, W Jiang, J He
Frontiers in pharmacology 2021
Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
C Lee, M Kim, J Han, M Yoon, Y Jung
Biomedicines 2021
Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis
A Charchanti, P Kanavaros, E Koniaris, A Kataki, G Glantzounis, NJ Agnantis, AC Goussia
In vivo (Athens, Greece) 2021
Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
M Migdał, E Tralle, KA Nahia, Ł Bugajski, KZ Kędzierska, F Garbicz, K Piwocka, CL Winata, M Pawlak
BMC Genomics 2021
The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis
H Fuji, G Miller, T Nishio, Y Koyama, K Lam, V Zhang, R Loomba, D Brenner, T Kisseleva
Frontiers in Molecular Biosciences 2021
Engineering and Monitoring 3D Cell Constructs with Time-Evolving Viscoelasticity for the Study of Liver Fibrosis In Vitro.
Cacopardo L, Ahluwalia A
2021
A narrative review of liver regeneration—from models to molecular basis
Huang W, Han N, Du L, Wang M, Chen L, Tang H
Annals of translational medicine 2021
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
N Roehlen, E Crouchet, TF Baumert
Cells 2020
Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis
CY Lee, FM Suk, YC Twu, YJ Liao
International journal of environmental research and public health 2020
Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice
XY Xu, Y Du, X Liu, Y Ren, Y Dong, HY Xu, JS Shi, D Jiang, X Xu, L Li, ZH Xu, Y Geng
Cell Communication and Signaling 2020
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner
Nature Reviews Gastroenterology & Hepatology 2020
Role of TGF‑β1‑mediated epithelial‑mesenchymal transition in the pathogenesis of tympanosclerosis
J Qiu, Y Wang, W Guo, L Xu, Y Mou, L Cui, F Han, Y Sun
Experimental and therapeutic medicine 2020
The Endothelium as a Driver of Liver Fibrosis and Regeneration
E Lafoz, M Ruart, A Anton, A Oncins, V Hernández-Gea
Cells 2020
Pro- and Anti-fibrogenic Functions of Gram-Negative Bacterial Lipopolysaccharide in the Liver
CR Gandhi
Frontiers in Medicine 2020
Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair
L da Silva Meirelles, RF Marson, MI Solari, NB Nardi
Cells 2020
[18F]- Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis
T Shao, Z Chen, V Belov, X Wang, SH Rwema, V Kumar, H Fu, X Deng, J Rong, Q Yu, L Lang, W Lin, L Josephson, AE Samir, X Chen, RT Chung, SH Liang
Journal of Hepatology 2020
Mechanisms of liver fibrosis and its role in liver cancer
D Dhar, J Baglieri, T Kisseleva, DA Brenner
Experimental biology and medicine (Maywood, N.J.) 2020
Lipid nanoparticle technology for therapeutic gene regulation in the liver
D Witzigmann, JA Kulkarni, J Leung, S Chen, PR Cullis, R van der Meel
Advanced Drug Delivery Reviews 2020
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats
W Li, C Zhou, Y Fu, T Chen, X Liu, Z Zhang, T Gong
Acta pharmaceutica Sinica. B 2020
Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis
J Zhang, ES Muise, S Han, PS Kutchukian, P Costet, Y Zhu, Y Kan, H Zhou, V Shah, Y Huang, A Saigal, TE Akiyama, XL Shen, TQ Cai, K Shah, E Carballo-Jane, E Zycband, L Yi, Y Tian, Y Chen, J Imbriglio, E Smith, K Devito, J Conway, LJ Ma, M Hoek, IK Sebhat, AM Peier, S Talukdar, DG McLaren, SF Previs, KK Jensen, S Pinto
Reproduction 2020
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against Decapentaplegic, and CCAAT/Enhancer‐Binding Protein C/EBP Transcription Factors
A Sharma, AK Verma, M Kofron, R Kudira, A Miethke, T Wu, J Wang, CR Gandhi
Hepatology 2020
Fuzheng Huayu Capsule Attenuates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells
M Wu, Y Zhou, SL Qin, LJ Lin, J Ping, Z Tao, J Zhang, LM Xu, J Wu
Evidence-Based Complementary and Alternative Medicine 2020
Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models
BL Li, JJ Hu, JD Xie, C Ni, HJ Liang, QR Li, J Yuan, JW Wu, J Wan
Evidence-Based Complementary and Alternative Medicine 2020
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway
Z Wang, ZX Cheng, ST Abrams, ZQ Lin, ED Yates, Q Yu, WP Yu, PS Chen, CH Toh, GZ Wang
World journal of gastroenterology : WJG 2020
Intravenous Umbilical Cord-derived Mesenchymal Stem Cells Transplantation Regulates Hyaluronic Acid and Interleukin-10 Secretion Producing Low-grade Liver Fibrosis in Experimental Rat.
Sungkar T, Putra A, Lindarto D, Sembiring RJ
2020
Upregulation of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in A Rat Model with Cirrhotic Liver.
Jun JH, Jung J, Kim JY, Hwang SG, Bae SH, Kim GJ
International journal of stem cells 2020
TGF-β1 accelerates the hepatitis B virus X-induced malignant transformation of hepatic progenitor cells by upregulating miR-199a-3p
K Dong, Y Chen, G Yang, Z Liao, H Zhang, H Liang, X Chen, H Dong
Oncogene 2019
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
B Hinz, D Lagares
Nature Reviews Rheumatology 2019
Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice
ZY Chang, CC Chen, HM Liu, YC Yeh, TY Lin, TY Lee, TH Huang
International journal of molecular sciences 2019
Mechanisms for the Resolution of Organ Fibrosis
JC Horowitz, VJ Thannickal
Physiology (Bethesda, Md.) 2019
A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
RE Sharkawy, A Bayoumi, M Metwally, A Mangia, T Berg, M Romero-Gomez, ML Abate, WL Irving, D Sheridan, GJ Dore, U Spengler, P Lampertico, E Bugianesi, M Weltman, L Mollison, W Cheng, S Riordan, R Santoro, R Gallego-Durán, J Fischer, J Nattermann, R DAmbrosio, D McLeod, E Powell, O latchoumanin, K Thabet, MA Najim, MW Douglas, C Liddle, L Qiao, J George, M Eslam
Scientific Reports 2019
MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H+ Transporting V1 Subunit C1
F Jing, Y Geng, XY Xu, HY Xu, JS Shi, ZH Xu
International journal of molecular sciences 2019
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation
YH Huang, HC Kuo, YL Yang, FS Wang
International journal of medical sciences 2019
AICD: an integrated anti-inflammatory compounds database for drug discovery
K Wang, J Xiao, X Liu, Z Jiang, Y Zhan, T Yin, L He, F Zhang, S Xing, B Chen, Y Li, F Zhang, Z Kuang, B Du, J Gu
Scientific Reports 2019
Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model
MR Park, MS Wong, MJ Araúzo-Bravo, H Lee, D Nam, SY Park, HD Seo, SM Lee, HF Zeilhofer, H Zaehres, HR Schöler, JB Kim, LA van Grunsven
PloS one 2019
A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation
MD Muthiah, DQ Huang, L Zhou, NH Jumat, M Choolani, JK Chan, A Wee, SG Lim, YY Dan
Scientific Reports 2019
Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis
N JalanSakrikar, TM Assuncao, G Shi, SO Aseem, C Chi, VH Shah, RC Huebert
Hepatology 2019
Validation of Novel Fibrosis Index (NFI) for assessment of liver fibrosis: comparison with transient elastography (FibroScan)
A Hussain, MA Gul, MU Khalid
BMJ Open Gastroenterology 2019
Prospective comparison of transient, point shear wave, and magnetic resonance elastography for staging liver fibrosis
T Lefebvre, C Wartelle-Bladou, P Wong, G Sebastiani, JM Giard, H Castel, J Murphy-Lavallée, D Olivié, A Ilinca, MP Sylvestre, G Gilbert, ZH Gao, BN Nguyen, G Cloutier, A Tang
European Radiology 2019
Level and Value of T Cell-derived Circulating Microparticles in Liver Cirrhosis Patients
CHEN CH, CHANG CL, CHEN KH, CHENG BC, CHEN HH, CHIANG JY, SUNG PH, YIP HK
In vivo (Athens, Greece) 2019
Pathological changes of liver one year later in CHB patients with negative HBV DNA
Shanshan W, Xinfang D, Shuihong Y, Kecong L, Jinjin Q, Zhi C, Feng C
Infectious agents and cancer 2019
KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation.
Legaz I, Bolarín JM, Navarro E, Campillo JA, Moya R, Pérez-Cárceles MD, Luna A, Osuna E, Miras M, Muro M, Minguela A, Alvarez López R
Archives of Medical Science : AMS 2019
Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis.
Hu P, Sun J, Lv F, Pi B, Xu F, Han G, Hu X, Wang Y, Huang N, Wu X, Yang X
2019
Role of Hepatic Deposited Immunoglobulin G in the Pathogenesis of Liver Damage in Systemic Lupus Erythematosus
X Fang, MH Zaman, X Guo, H Ding, C Xie, X Zhang, GM Deng
Frontiers in immunology 2018
Combatting Fibrosis: Exosome‐Based Therapies in the Regression of Liver Fibrosis
L Chen, DA Brenner, T Kisseleva
Hepatology Communications 2018
PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis
Y Yang, X Wu, W Li, H Huang, H Li, X Pan, X Li, C Huang, X Meng, L Zhang, X Lv, H Wang, J Li
Oncogene 2018
Emerging Role of HMGB1 in the Pathogenesis of Schistosomiasis Liver Fibrosis
AR Vicentino, VC Carneiro, D Allonso, R de Freitas Guilherme, CF Benjamim, HA dos Santos, F Xavier, A dos Santos Pyrrho, J de Assis Silva Gomes, M de Castro Fonseca, RC de Oliveira, TA Pereira, L Ladislau, JR Lambertucci, MR Fantappié
Frontiers in immunology 2018
Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis
M Praktiknjo, J Lehmann, MJ Nielsen, R Schierwagen, FE Uschner, C Meyer, D Thomas, CP Strassburg, F Bendtsen, S Møller, A Krag, MA Karsdal, DJ Leeming, J Trebicka
Hepatology Communications 2018
Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling
C Balta, A Ciceu, H Herman, M Rosu, OM Boldura, A Hermenean
Dose-Response 2018
Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility
JI Fortea, C Fernández-Mena, M Puerto, C Ripoll, J Almagro, J Bañares, JM Bellón, R Bañares, J Vaquero
Scientific Reports 2018
Flavanones from Sedum sarmentosum Bunge Alleviate CCl 4 -Induced Liver Fibrosis in Rats by Targeting TGF- β 1/T β R/Smad Pathway In Turn Inhibiting Epithelial Mesenchymal Transition
Y Lin, H Luo, X Wang, M Zheng, Q Jin, H Chen, P Pan, J Zhang
Evidence-Based Complementary and Alternative Medicine 2018
Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts
R Weiskirchen, S Weiskirchen, F Tacke
F1000Research 2018
Evaluation of Plasma Urokinase-Type Plasminogen Activator Receptor (UPAR) in Patients With Chronic Hepatitis B, C and Non-Alcoholic Fatty Liver Disease (NAFLD) as Serological Fibrosis Marker
Ö Akdoğan, AA Yücel, ZG Sargin, C Sönmez, GE Yilmaz, S Özenirler
Journal of Clinical and Experimental Hepatology 2018
Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review
NX Hoan, HV Tong, LH Song, CG Meyer, TP Velavan
World journal of gastroenterology : WJG 2018
Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study
NM El-Lakkany, WH El-Maadawy, SH el-Din, S Saleh, MM Safar, SM Ezzat, SH Mohamed, SS Botros, Z Demerdash, OA Hammam
Journal of traditional and complementary medicine 2018
Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism)
M Khatami
Clinical and Translational Medicine 2018
Liver function tests in identifying patients with liver disease
Z Ahmed, U Ahmed, S Walayat, J Ren, DK Martin, H Moole, S Koppe, S Yong, S Dhillon
Clinical and experimental gastroenterology 2018
Accumulation of citrullinated glial fibrillary acidic protein in a mouse model of bile duct ligation-induced hepatic fibrosis
SE Kim, JW Park, MJ Kim, B Jang, YC Jeon, HJ Kim, A Ishigami, HS Kim, KT Suk, DJ Kim, CK Park, EK Choi, MK Jang, LA van Grunsven
PloS one 2018
Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis
S Al-Fayoumi, T Hashiguchi, Y Shirakata, J Mascarenhas, JW Singer
Journal of Experimental Pharmacology 2018
Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice
D Yuan, T Xiang, Y Huo, C Liu, T Wang, Z Zhou, Y Dun, H Zhao, C Zhang
Archives of Medical Science : AMS 2018
CM-101: Type I Collagen–targeted MR Imaging Probe for Detection of Liver Fibrosis
CT Farrar, EM Gale, R Kennan, I Ramsay, R Masia, G Arora, K Looby, L Wei, J Kalpathy-Cramer, MM Bunzel, C Zhang, Y Zhu, TE Akiyama, M Klimas, S Pinto, H Diyabalanage, KK Tanabe, V Humblet, BC Fuchs, P Caravan
Radiology 2018
Molecular Characterization of a Precision-Cut Rat Liver Slice Model for the Evaluation of Anti-Fibrotic Compounds
X Huang, H Cai, R Ammar, Y Zhang, Y Wang, K Ravi, JR Thompson, G Jarai
AJP Gastrointestinal and Liver Physiology 2018
Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies
S Cannito, C Milani, A Cappon, M Parola, M Strazzabosco, M Cadamuro
International journal of molecular sciences 2018
Universal Index for Cirrhosis (UIC index): The development and validation of a novel index to predict advanced liver disease
Z Ahmed, J Ren, A Gonzalez, U Ahmed, S Walayat, DK Martin, H Moole, S Yong, S Koppe, S Dhillon
Hepatic medicine : evidence and research 2018
Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat
Aliasghar Parvaresh Anbar, Tayyebeh Piran, Mehrdad Farhadi, Pouran Karimi
Iranian Journal of Basic Medical Sciences 2018
Liver fibrosis
MM Aydin, KC Akcali
TURK J GASTROENTEROL 2018
Quantitative ultrasound and machine learning for assessment of steatohepatitis in a rat model.
Tang A, Destrempes F, Kazemirad S, Garcia-Duitama J, Nguyen BN, Cloutier G
European Radiology 2018
Platelets prime hematopoietic–vascular niche to drive angiocrine-mediated liver regeneration
K Shido, D Chavez, Z Cao, JL Ko, S Rafii, BS Ding
Signal Transduction and Targeted Therapy 2017
Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis
CX Cai, H Buddha, S Castelino-Prabhu, Z Zhang, RS Britton, BR Bacon, BA Neuschwander-Tetri
Digestive Diseases and Sciences 2017
Direct orthotopic implantation of hepatic organoids
VX Zhou, M Lolas, TT Chang
Journal of Surgical Research 2017
Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging
A Müller, K Hochrath, J Stroeder, K Hittatiya, G Schneider, F Lammert, A Buecker, P Fries
BioMed Research International 2017
Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis
ME de França, SW Rocha, WH Oliveira, LA Santos, AG de Oliveira, KP Barbosa, AK Nunes, GB Rodrigues, DB Lós, CA Peixoto
Inflammopharmacology 2017
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis
MJ Bollong, B Yang, N Vergani, BA Beyer, EN Chin, C Zambaldo, D Wang, AK Chatterjee, LL Lairson, PG Schultz
Proceedings of the National Academy of Sciences 2017
Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis
V Prestigiacomo, A Weston, S Messner, F Lampart, L Suter-Dick, P Mukhopadhyay
PloS one 2017
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
HD Singh, I Otano, K Rombouts, KP Singh, D Peppa, US Gill, K Böttcher, PT Kennedy, J Oben, M Pinzani, H Walczak, G Fusai, WM Rosenberg, MK Maini
Scientific Reports 2017
Differentiation of fibrotic liver tissue using laser-induced breakdown spectroscopy
E Teran-Hinojosa, H Sobral, C Sánchez-Pérez, A Pérez-García, N Alemán-García, J Hernández-Ruiz
Biomedical Optics Express 2017
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet
WG Choi, J Han, JH Kim, MJ Kim, JW Park, B Song, HJ Cha, HS Choi, HT Chung, IK Lee, TS Park, M Hatzoglou, HS Choi, HJ Yoo, RJ Kaufman, SH Back
Nutrition & Metabolism 2017
β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis
Y Wang, AM Terrell, BA Riggio, D Anand, SA Lachke, MK Duncan
Investigative ophthalmology & visual science 2017
Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats
KH Lu, CY Weng, WC Chen, LY Sheen
Journal of Ginseng Research 2017
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
N Ikenaga, ZW Peng, KA Vaid, SB Liu, S Yoshida, DY Sverdlov, A Mikels-Vigdal, V Smith, D Schuppan, YV Popov
Gut 2017
IL-33-ST2 Axis in Liver Disease: Progression and Challenge
Z Sun, B Chang, M Gao, J Zhang, Z Zou
Mediators of Inflammation 2017
Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial
PN Newsome, R Fox, AL King, D Barton, NN Than, J Moore, C Corbett, S Townsend, J Thomas, K Guo, D Hull, HA Beard, J Thompson, A Atkinson, C Bienek, N McGowan, N Guha, J Campbell, D Hollyman, D Stocken, C Yap, SJ Forbes
The Lancet Gastroenterology & Hepatology 2017
The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology
X Ou, S Mao, J Cao, Y Ma, G Ma, A Cheng, M Wang, D Zhu, S Chen, R Jia, M Liu, K Sun, Q Yang, Y Wu, X Chen
Oncotarget 2017
Hepatic Fibrosis in Dogs
VM Eulenberg, JA Lidbury
Journal of Veterinary Internal Medicine 2017
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis
VS Athwal, J Pritchett, J Llewellyn, K Martin, E Camacho, SM Raza, A PhythianAdams, LJ Birchall, AF Mullan, K Su, L Pearmain, G Dolman, AM Zaitoun, SL Friedman, A MacDonald, WL Irving, IN Guha, NA Hanley, KP Hanley
EMBO Molecular Medicine 2017
Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
F Yang, L Luo, ZD Zhu, X Zhou, Y Wang, J Xue, J Zhang, X Cai, ZL Chen, Q Ma, YF Chen, YJ Wang, YY Luo, P Liu, L Zhao
Frontiers in pharmacology 2017
IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.
Eslam M, McLeod D, Kelaeng KS, Mangia A, Berg T, Thabet K, Irving WL, Dore GJ, Sheridan D, Grønbæk H, Abate ML, Hartmann R, Bugianesi E, Spengler U, Rojas A, Booth DR, Weltman M, Mollison L, Cheng W, Riordan S, Mahajan H, Fischer J, Nattermann J, Douglas MW, Liddle C, Powell E, Romero-Gomez M, George J
Nature Genetics 2017
Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease
BM McGettigan, RH McMahan, Y Luo, XX Wang, DJ Orlicky, C Porsche, M Levi, HR Rosen
The Journal of biological chemistry 2016
Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases
S Li, M Hong, HY Tan, N Wang, Y Feng
Oxidative medicine and cellular longevity 2016
Versican: a novel modulator of hepatic fibrosis
TN Bukong, SB Maurice, B Chahal, DF Schaeffer, PJ Winwood
Laboratory Investigation 2016
Role of thrombospondin 1 in liver diseases: TSP1 in liver disease
Y Li, CP Turpin, S Wang
Hepatology Research 2016
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice
LN Chow, P Schreiner, BY Ng, B Lo, MR Hughes, RW Scott, V Gusti, S Lecour, E Simonson, I Manisali, I Barta, KM McNagny, J Crawford, M Webb, TM Underhill, P Mukhopadhyay
PloS one 2016
Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with 99mTc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice
D Zhang, Z Guo, P Zhang, Y Li, X Su, L You, M Gao, C Liu, H Wu, X Zhang
Scientific Reports 2016
A potential role for genome structure in the translation of mechanical force during immune cell development
E Jacobson, JK Perry, DS Long, MH Vickers, JM O'Sullivan
Nucleus 2016
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury
P Rantakari, DA Patten, J Valtonen, M Karikoski, H Gerke, H Dawes, J Laurila, S Ohlmeier, K Elima, SG Hübscher, CJ Weston, S Jalkanen, DH Adams, M Salmi, S Shetty
Proceedings of the National Academy of Sciences 2016
Adverse outcome pathway development from protein alkylation to liver fibrosis
T Horvat, B Landesmann, A Lostia, M Vinken, S Munn, M Whelan
Archives of Toxicology 2016
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury
AJ Paris, Y Liu, J Mei, N Dai, L Guo, LA Spruce, KM Hudock, JS Brenner, WJ Zacharias, HD Mei, AR Slamowitz, K Bhamidipati, MF Beers, SH Seeholzer, EE Morrisey, GS Worthen
American journal of physiology. Lung cellular and molecular physiology 2016
Biomarker-Based Approaches for Assessing Alcohol Use Disorders
O Niemelä
International journal of environmental research and public health 2016
The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis
D Karin, Y Koyama, D Brenner, T Kisseleva
Differentiation 2016
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
KA Lytle, DB Jump, H Guillou
PloS one 2016
Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis
E Hintermann, M Bayer, J Ehser, M Aurrand-Lions, JM Pfeilschifter, BA Imhof, U Christen
Cell adhesion & migration 2016
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
YC Twu, TS Lee, YL Lin, SM Hsu, YH Wang, CY Liao, CK Wang, YC Liang, YJ Liao
International journal of molecular sciences 2016
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis
M Rezvani, R Español-Suñer, Y Malato, L Dumont, AA Grimm, E Kienle, JG Bindman, E Wiedtke, BY Hsu, SJ Naqvi, RF Schwabe, CU Corvera, D Grimm, H Willenbring
Cell Stem Cell 2016
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ3 for staging liver fibrosis in rat model
DB Wang, C Zhang, H Liu, Y Cui, X Li, Z Zhang, Y Zhang
International Journal of Nanomedicine 2016
Mechanocompatible Polymer-Extracellular-Matrix Composites for Vascular Tissue Engineering
B Jiang, R Suen, JJ Wang, ZJ Zhang, JA Wertheim, GA Ameer
Advanced Healthcare Materials 2016
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
K Thabet, A Asimakopoulos, M Shojaei, M Romero-Gomez, A Mangia, WL Irving, T Berg, GJ Dore, H Grønbæk, D Sheridan, ML Abate, E Bugianesi, M Weltman, L Mollison, W Cheng, S Riordan, J Fischer, U Spengler, J Nattermann, A Wahid, A Rojas, R White, MW Douglas, D McLeod, E Powell, C Liddle, D der Poorten, J George, M Eslam, R Gallego-Duran, T Applegate, M Bassendine, C Rosso, L Mezzabotta, R Leung, B Malik, G Matthews, J Grebely, V Fragomeli, JR Jonsson, R Santaro
Nature Communications 2016
Pentoxifylline inhibits liver fibrosis via hedgehog signaling pathway
H Li, J Hua, C Guo, W Wang, B Wang, D Yang, P Wei, Y Lu
Journal of Huazhong University of Science and Technology [Medical Sciences] 2016
A deleterious role for Th9/IL-9 in hepatic fibrogenesis
S Qin, D Lu, X Guo, W Luo, B Hu, X Huang, M Chen, J Wang, SJ Ma, X Yang, H Jiang, Y Zhou
Scientific Reports 2016
Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia: Matrix metalloproteinases in biliary atresia
A Kerola, H Lampela, J Lohi, P Heikkilä, A Mutanen, J Hagström, T Tervahartiala, T Sorsa, C Haglund, H Jalanko, MP Pakarinen
The Journal of Pathology: Clinical Research 2016
The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig: Placental insufficiency and LBW, Western diet and fibrosis
O Sarr, A Blake, JA Thompson, L Zhao, K Rabicki, JC Walsh, I Welch, TR Regnault
The Journal of Physiology 2016
Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
HT Schon, M Bartneck, E Borkham-Kamphorst, J Nattermann, T Lammers, F Tacke, R Weiskirchen
Frontiers in pharmacology 2016
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis
N Fransén-Pettersson, N Duarte, J Nilsson, M Lundholm, S Mayans, Å Larefalk, TD Hannibal, L Hansen, A Schmidt-Christensen, F Ivars, S Cardell, R Palmqvist, B Rozell, D Holmberg, MA Avila
PloS one 2016
Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease?
W Seo
World journal of gastroenterology : WJG 2016
The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity
H Attia, N Al-Rasheed, R Mohamad, N Al-Rasheed, M Al-Amin
BMC complementary and alternative medicine 2016
Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells
S Bi, F Chu, M Wang, B Li, P Mao, H Zhang, P Wang, W Guo, L Xu, L Ren, H Lei, Y Zhang
Molecules (Basel, Switzerland) 2016
Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model: Zhu et al
B Zhu, L Wei, N Rotile, H Day, T Rietz, CT Farrar, GY Lauwers, KK Tanabe, B Rosen, BC Fuchs, P Caravan
Hepatology 2016
Novel therapeutic targets in primary biliary cirrhosis
JK Dyson, GM Hirschfield, DH Adams, U Beuers, DA Mann, KD Lindor, DE Jones
Nature Reviews Gastroenterology & Hepatology 2015
The role of TGFβ1 and LRG1 in cardiac remodelling and heart failure
W Song, X Wang
Biophysical Reviews 2015
Epithelial–Mesenchymal Transition in Kidney Tubular Epithelial Cells Induced by Globotriaosylsphingosine and Globotriaosylceramide
YJ Jeon, N Jung, JW Park, HY Park, SC Jung, JW Lee
PloS one 2015
Substrate-specific gene expression profiles in different kidney cell types are associated with Fabry disease
YJ Shin, Y Jeon, N Jung, JW Park, HY Park, SC Jung
Molecular medicine reports 2015
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva
Experimental biology and medicine (Maywood, N.J.) 2015
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
KE Kim, H Kim, RW Heo, HJ Shin, C Yi, DH Lee, HJ Kim, SS Kang, GJ Cho, WS Choi, GS Roh
The Korean Journal of Physiology & Pharmacology 2015
Identifying Molecular Targets to Improve Immune Function in Alcoholic Hepatitis
R Bataller, P Mandrekar
Gastroenterology 2015
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M
JA Richards, M Bucsaiova, EE Hesketh, C Ventre, NC Henderson, K Simpson, CO Bellamy, SE Howie, SM Anderton, J Hughes, SJ Wigmore, CM Stover
PloS one 2015
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis
S Amara, K Lopez, B Banan, SK Brown, M Whalen, E Myles, MT Ivy, T Johnson, KL Schey, V Tiriveedhi
Molecular Immunology 2015
Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF- β 1/Smad Signaling
N Lu, Y Liu, A Tang, L Chen, D Miao, X Yuan
BioMed Research International 2015
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
M Eslam, AM Hashem, R Leung, M Romero-Gomez, T Berg, GJ Dore, HL Chan, WL Irving, D Sheridan, ML Abate, LA Adams, A Mangia, M Weltman, E Bugianesi, U Spengler, O Shaker, J Fischer, L Mollison, W Cheng, E Powell, J Nattermann, S Riordan, D McLeod, NJ Armstrong, MW Douglas, C Liddle, DR Booth, J George, G Ahlenstiel, J Ampuero, M Bassendine, VW Wong, C Rosso, R White, L Mezzabotta, V Suppiah, M Michalk, B Malik, G Matthews, T Applegate, J Grebely, V Fragomeli, JR Jonsson, R Santaro
Nature Communications 2015
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice
TR Harris, A Bettaieb, S Kodani, H Dong, R Myers, N Chiamvimonvat, FG Haj, BD Hammock
Toxicology and Applied Pharmacology 2015
Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor- β 1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats
NM Al-Rasheed, HA Attia, RA Mohamad, NM Al-Rasheed, MA Al-Amin, A AL-Onazi
Evidence-Based Complementary and Alternative Medicine 2015
Reversibility and heritability of liver fibrosis: Implications for research and therapy
Hussein M Atta
World journal of gastroenterology : WJG 2015
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
Bo Liang, Xiao-Ling Guo, Jing Jin, Yong-Chun Ma, Zheng-Quan Feng
World journal of gastroenterology : WJG 2015
Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions
A Tang, G Cloutier, NM Szeverenyi, CB Sirlin
AJR. American journal of roentgenology 2015
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels
R Weiskirchen, A Mahli, S Weiskirchen, C Hellerbrand
Frontiers in physiology 2015
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface
S Xu, CH Kang, X Gou, Q Peng, J Yan, S Zhuo, CL Cheng, Y He, Y Kang, W Xia, PT So, R Welsch, JC Rajapakse, H Yu
Journal of Biophotonics 2015
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
MJ Nielsen, J Lehmann, DJ Leeming, R Schierwagen, S Klein, C Jansen, CP Strassburg, F Bendtsen, S Møller, T Sauerbruch, MA Karsdal, A Krag, J Trebicka
Digestive Diseases and Sciences 2015
Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice
M Ganz, TN Bukong, T Csak, B Saha, JK Park, A Ambade, K Kodys, G Szabo
Journal of Translational Medicine 2015
3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model
CT Farrar, DK DePeralta, H Day, TA Rietz, L Wei, GY Lauwers, B Keil, A Subramaniam, AJ Sinskey, KK Tanabe, BC Fuchs, P Caravan
Journal of Hepatology 2015
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice
L Ye, H Yu, C Li, ML Hirsch, L Zhang, RJ Samulski, W Li, Z Liu, X Meng
PloS one 2015
Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo
Y Wang, X Zhang, Y Yang, X Yang, B Ye
Marine drugs 2015
Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver: Liver Biology/Pathobiology
HW Zimmermann, T Bruns, CJ Weston, SM Curbishley, E Liaskou, KK Li, YJ Resheq, PW Badenhorst, DH Adams
Hepatology 2015
Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
CS Nowell, PD Odermatt, L Azzolin, S Hohnel, EF Wagner, GE Fantner, MP Lutolf, Y Barrandon, S Piccolo, F Radtke
Nature Cell Biology 2015
Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps
KA Bailey, AH Smith, EJ Tokar, JH Graziano, KW Kim, P Navasumrit, M Ruchirawat, A Thiantanawat, WA Suk, RC Fry
Environmental Health Perspectives 2015
Pathophysiology of Portal Hypertension
Morales-Ruiz M, Rodríguez-Vita J, Ribera J, Jiménez W
PanVascular Medicine 2015
Vascular Adhesion Protein-1 Promotes Liver Inflammation and Drives Hepatic Fibrosis
Chris Weston, Emma Shepherd, Lee Claridge, Pia rantakari, Stuart Curbishley, Jeremy Tomlinson, Stefan Hubscher, Gary Reynolds, Kristiina Aalto, Quentin Anstee, Sirpa Jalkanen, Marko Salmi, David Smith, Christopher Day, David Adams
Journal of Clinical Investigation 2014
IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice: HEPATOLOGY, Vol. XX, No. X, 2014
A Mitra, A Satelli, J Yan, X Xueqing, M Gagea, CA Hunter, L Mishra, S Li
Hepatology 2014
Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition
SJ Lee, KH Kim, KK Park
World journal of hepatology 2014
Evidence of endoplasmic reticulum stress and liver inflammation in the American mink Neovison vison with benign hepatic steatosis
K Rouvinen-Watt, C Pal, T Martin, L Harris, T Astatkie, D Kryzskaya, V Kärjä, AM Mustonen, R Tammi, M Tammi, P Nieminen
Journal of Comparative Physiology B 2014
Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
X Wang, W Zhao, J Wang, K Shi, X Qin, Q Kong, G Wang, L Mu, H Li, B Sun, L Shi
Digestive Diseases and Sciences 2014
Virus-related liver cirrhosis: Molecular basis and therapeutic options
J Lin, JF Wu, Q Zhang, HW Zhang, GW Cao
World journal of gastroenterology : WJG 2014
Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans
L Beljaars, M Schippers, C Reker-Smit, FO Martinez, L Helming, K Poelstra, BN Melgert
Frontiers in immunology 2014
Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: Role of NADPH oxidase
M Wang, JM Abais, N Meng, Y Zhang, JK Ritter, PL Li, WX Tang
Free radical biology & medicine 2014
A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression
J Dutta-Moscato, A Solovyev, Q Mi, T Nishikawa, A Soto-Gutierrez, IJ Fox, Y Vodovotz
Frontiers in Bioengineering and Biotechnology 2014
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
Y Kong, H Wang, S Wang, N Tang
Inflammation 2014
Extracellular Matrix and Liver Disease
E Arriazu, MR de Galarreta, FJ Cubero, M Varela-Rey, MP de Obanos, TM Leung, A Lopategi, A Benedicto, I Abraham-Enachescu, N Nieto
Antioxidants & Redox Signaling 2014
Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation
X Yang, ZP Han, SS Zhang, PX Zhu, C Hao, TT Fan, Y Yang, L Li, YF Shi, LX Wei
Cell Death and Disease 2014
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury
I Lua, D James, J Wang, KS Wang, K Asahina
Hepatology 2014
Difference in glycerol levels between leukemia and normal bone marrow stem cells
YS Qin, DX Bu, YY Cui, XY Zhang
Oncology Letters 2014
Resolvin E1 reduces hepatic fibrosis in mice with Schistosoma japonicum infection
W Qiu, K Guo, L Yi, Y Gong, L Huang, W Zhong
Experimental and therapeutic medicine 2014
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy
M Shen, K Chen, J Lu, P Cheng, L Xu, W Dai, F Wang, L He, Y Zhang, W Chengfen, J Li, J Yang, R Zhu, H Zhang, Y Zheng, Y Zhou, C Guo
Mediators of Inflammation 2014
Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update
GÖ Elpek
World journal of gastroenterology : WJG 2014
Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells
J Pritchett, VS Athwal, E Harvey, K Martin, J Llewellyn, P Ireland, A Nicolaides, MJ Humphries, N Bobola, NA Hanley, KP Hanley
PloS one 2014
Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis
K Sakai, S Jawaid, T Sasaki, G Bou-Gharios, T Sakai
The American Journal of Pathology 2014
Cell and tissue engineering for liver disease
SN Bhatia, GH Underhill, KS Zaret, IJ Fox
Science Translational Medicine 2014
Mutant MMP-9 and HGF Gene Transfer Enhance Resolution of CCl4-Induced Liver Fibrosis in Rats: Role of ASH1 and EZH2 Methyltransferases Repression
H Atta, M El-Rehany, O Hammam, H Abdel-Ghany, M Ramzy, M Roderfeld, E Roeb, A Al-Hendy, SA Raheim, H Allam, H Marey, MA Avila
2014
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF
M Bernard, M Dieudé, B Yang, K Hamelin, K Underwood, MJ Hébert
Autophagy 2014
Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl 4 -) Induced Liver Injury in Mice
SW Rocha, ME de França, GB Rodrigues, KP Barbosa, AK Nunes, AF Pastor, AG Oliveira, WH Oliveira, RL Luna, CA Peixoto
Mediators of Inflammation 2014
Emerging role of HMGB1 in fibrotic diseases
LC Li, J Gao, J Li
Journal of Cellular and Molecular Medicine 2014
SHSST Cyclodextrin Complex Prevents the Fibrosis Effect on CCl4-Induced Cirrhotic Cardiomyopathy in Rats through TGF-β Pathway Inhibition Effects
CH Yang, WJ Ting, C Day, DT Ju, YL Yeh, LC Chung, FJ Tsai, CH Tsai, Y Tsai, CY Huang
International journal of molecular sciences 2014
Insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) contributes to liver inflammation and fibrosis via activation of the ERK1/2 pathway.
Guo Y, Zhang Y, Zhang Q, Guo X, Zhang H, Zheng G, Liu L
Hepatology International 2014
Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis
SC Beeman, LJ Mandarino, JF Georges, KM Bennett
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013
Molecular MRI of collagen to diagnose and stage liver fibrosis
BC Fuchs, H Wang, Y Yang, L Wei, M Polasek, DT Schühle, GY Lauwers, A Parkar, AJ Sinskey, KK Tanabe, P Caravan
Journal of Hepatology 2013
A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
M Fujii, Y Shibazaki, K Wakamatsu, Y Honda, Y Kawauchi, K Suzuki, S Arumugam, K Watanabe, T Ichida, H Asakura, H Yoneyama
Medical Molecular Morphology 2013
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription
B Xu, SH Li, R Zheng, SB Gao, LH Ding, ZY Yin, X Lin, ZJ Feng, S Zhang, XM Wang, GH Jin
Proceedings of the National Academy of Sciences 2013
RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats
Z Luo, H Liu, X Sun, R Guo, R Cui, X Ma, M Yan
PloS one 2013
PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model
SJ Lee, JH Kang, SY Choi, KT Suk, DJ Kim, OS Kwon
PloS one 2013
Hepatic regeneration and the epithelial to mesenchymal transition
ZF Xue, XM Wu, M Liu
World journal of gastroenterology : WJG 2013
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
BS Ding, Z Cao, R Lis, DJ Nolan, P Guo, M Simons, ME Penfold, K Shido, SY Rabbany, S Rafii
Nature 2013
Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis
S Cabrera, M Selman, A Lonzano-Bolaños, K Konishi, TJ Richards, N Kaminski, A Pardo
American journal of physiology. Lung cellular and molecular physiology 2013
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
QM Anstee, G Targher, CP Day
Nature Reviews Gastroenterology & Hepatology 2013
Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure
MA Karsdal, MJ Nielsen, JM Sand, K Henriksen, F Genovese, AC Bay-Jensen, V Smith, JI Adamkewicz, C Christiansen, DJ Leeming
ASSAY and Drug Development Technologies 2013
Canine visceral leishmaniasis as a systemic fibrotic disease
LC Silva, RS Castro, MM Figueiredo, MS Michalick, WL Tafuri, WL Tafuri
International Journal of Experimental Pathology 2013
Contribution of Myofibroblasts of Different Origins to Liver Fibrosis
M Fausther, EG Lavoie, JA Dranoff
Current Pathobiology Reports 2013
Relaxin decreases the severity of established hepatic fibrosis in mice
RG Bennett, DG Heimann, S Singh, RL Simpson, DJ Tuma
Liver International 2013
Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts
X Liu, J Xu, DA Brenner, T Kisseleva
Current Pathobiology Reports 2013
The genetics of NAFLD
QM Anstee, CP Day
Nature Reviews Gastroenterology & Hepatology 2013
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis
P Mukhopadhyay, M Rajesh, Z Cao, B Horváth, O Park, H Wang, K Erdelyi, E Holovac, Y Wang, L Liaudet, N Hamdaoui, F Lafdil, G Haskó, C Szabo, AH Boulares, B Gao, P Pacher
Hepatology 2013
Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection
A Lamontagne, RE Long, MA Comunale, J Hafner, L Rodemich-Betesh, M Wang, J Marrero, AM di Bisceglie, T Block, A Mehta
PloS one 2013
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence
G Ramakrishna, A Rastogi, N Trehanpati, B Sen, R Khosla, SK Sarin
Liver Cancer 2013
Fibrosis: a key feature of Fabry disease with potential therapeutic implications
F Weidemann, MD Sanchez-Niño, J Politei, JP Oliveira, C Wanner, DG Warnock, A Ortiz
Orphanet Journal of Rare Diseases 2013
In vivo X-ray computed tomographic imaging of soft tissue with native, intravenous, or oral contrast
CA Wathen, N Foje, T Avermaete, B Miramontes, SE Chapaman, TA Sasser, R Kannan, S Gerstler, WM Leevy
Sensors (Basel, Switzerland) 2013
High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK
F Wang, L Li, J Li, J Wang, L Wang, W Jiang
PloS one 2013
Mutations in the catalytic domain of human matrix metalloproteinase-1 (MMP-1) that allow for regulated activity through the use of Ca2+
RD Paladini, G Wei, A Kundu, Q Zhao, LH Bookbinder, GA Keller, HM Shepard, GI Frost
The Journal of biological chemistry 2013
PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Induces Apoptosis of Activated Hepatic Stellate Cells in Vitro and in Vivo
D Parajuli, EJ Park, XH Che, WY Jiang, YC Kim, D Sohn, S Lee
Molecules (Basel, Switzerland) 2013
BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats.
Zhou XY, Yu ZJ, Yan D, Wang HM, Huang YH, Sha J, Xu FY, Cai ZY, Min WP
Inflammation 2013
Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism
JI Beier, GE Arteel
Experimental biology and medicine (Maywood, N.J.) 2012
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
ST Rashid, JD Humphries, A Byron, A Dhar, JA Askari, JN Selley, D Knight, RD Goldin, M Thursz, MJ Humphries
Journal of Proteome Research 2012
Reversibility of liver fibrosis
A Pellicoro, P Ramachandran, JP Iredale
Fibrogenesis & Tissue Repair 2012
IL-13 Signaling in Liver Fibrogenesis
Y Liu, S Munker, R Müllenbach, HL Weng
Frontiers in immunology 2012
Cell signals influencing hepatic fibrosis
M Cong, K Iwaisako, C Jiang, T Kisseleva
International Journal of Hepatology 2012
Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl4-Induced Acute Liver Injury
CC Chiu, CY Huang, TY Chen, SH Kao, JY Liu, YW Wang, BS Tzang, TC Hsu
Evidence-based complementary and alternative medicine : eCAM 2012
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis: The origin of myofibroblasts
K Iwaisako, DA Brenner, T Kisseleva
Journal of Gastroenterology and Hepatology 2012
Liver fibrosis: a bidirectional model of fibrogenesis and resolution
P Ramachandran, JP Iredale
QJM 2012
Immunological Orchestration of Liver Fibrosis
H Tanaka, PS Leung, TP Kenny, ME Gershwin, CL Bowlus
Clinical Reviews in Allergy & Immunology 2012
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats
X Chen, C Liu, Y Lu, Z Yang, Z Lv, Q Xu, Q Pan, L Lu
BMC complementary and alternative medicine 2012
Global analysis of DNA methylation in early-stage liver fibrosis
Y Komatsu, T Waku, N Iwasaki, W Ono, C Yamaguchi, J Yanagisawa
BMC Medical Genomics 2012
MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication
F Zhao, YX Wang, J Yuan, M Deng, HL Wong, ES Chu, MY Go, GJ Teng, AT Ahuja, J Yu
European Radiology 2012
Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate
Y Kim, MI Fiel, E Albanis, HI Chou, W Zhang, G Khitrov, SL Friedman
Liver International 2012
COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis
RP Favier, B Spee, BA Schotanus, TS van Ingh, H Fieten, B Brinkhof, CS Viebahn, LC Penning, J Rothuizen
PloS one 2012
Adipose derived mesenchymal stem cells transplantation via portal vein improves microcirculation and ameliorates liver fibrosis induced by CCl4 in rats
Y Wang, F Lian, J Li, W Fan, H Xu, X Yang, L Liang, W Chen, J Yang
Journal of Translational Medicine 2012
Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans
J Pritchett, E Harvey, V Athwal, A Berry, C Rowe, F Oakley, A Moles, DA Mann, N Bobola, AD Sharrocks, BJ Thomson, AM Zaitoun, WL Irving, IN Guha, NA Hanley, KP Hanley
Hepatology 2012
Prevalence and Importance of Comorbidities in Patients With Heart Failure
FK Triposkiadis, J Skoularigis
Current Heart Failure Reports 2012
Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside
F Zhang, D Kong, Y Lu, S Zheng
Cellular and Molecular Life Sciences 2012
Fibrogenic cell reversion underlies fibrosis regression in liver
SL Friedman
Proceedings of the National Academy of Sciences 2012
Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography
K Wahl, W Rosenberg, B Vaske, MP Manns, K Schulze-Osthoff, MJ Bahr, H Bantel
PloS one 2012
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats
Q Yao, B Xu, J Wang, H Liu, S Zhang, C Tu
BMC complementary and alternative medicine 2012
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models
M Polasek, BC Fuchs, R Uppal, DT Schühle, JK Alford, GS Loving, S Yamada, L Wei, GY Lauwers, AR Guimaraes, KK Tanabe, P Caravan
Journal of Hepatology 2012
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury.
Dulauroy S, Di Carlo SE, Langa F, Eberl G, Peduto L
Nature Medicine 2012
Prevention of Fibrosis Progression in CCl4-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems
Reichenbach V, Ros J, Fernández-Varo G, Casals G, Melgar-Lesmes P, Campos T, Makriyannis A, Morales-Ruiz M, Jiménez W
The Journal of pharmacology and experimental therapeutics 2012
Integrating mechanisms of pulmonary fibrosis
TA Wynn
Journal of Experimental Medicine 2011
Mesenchymal Cells of the Intestinal Lamina Propria
DW Powell, IV Pinchuk, JI Saada, X Chen, RC Mifflin
Annual Review of Physiology 2011
Innate immunity and PBC: Activated invariant NKT cells exacerbate murine autoimmune cholangitis and fibrosis
SJ Wu, YH Yang, K Tsuneyama, PS Leung, P Illarionov, ME Gershwin, YH Chuang
Hepatology 2011
Anti-fibrogenic Strategies and the regression of fibrosis
T Kisseleva, DA Brenner
Best practice & research. Clinical gastroenterology 2011
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
T Kisseleva, DA Brenner
Journal of Hepatology 2011
The lens as a model for fibrotic disease
JA Eldred, LJ Dawes, IM Wormstone
Philosophical Transactions of the Royal Society B: Biological Sciences 2011
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
TR Cox, JT Erler
Disease models & mechanisms 2011
Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies
MH Ismail, M Pinzani
Hepatic medicine : evidence and research 2011
Accelerated CCl4-Induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression
G Sebastiani, K Gkouvatsos, C Maffettone, G Busatto, M Guido, K Pantopoulos
PloS one 2011
Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
HW Zimmermann, S Seidler, N Gassler, J Nattermann, T Luedde, C Trautwein, F Tacke
PloS one 2011
A Transgenic Model for Conditional Induction and Rescue of Portal Hypertension Reveals a Role of VEGF-Mediated Regulation of Sinusoidal Fenestrations
D May, V Djonov, G Zamir, M Bala, R Safadi, M Sklair-Levy, E Keshet
PloS one 2011
Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632
MM van Beuge, J Prakash, M Lacombe, E Post, C Reker-Smit, L Beljaars, K Poelstra
Pharmaceutical Research 2011
Testing beneficial therapy in human cirrhosis using animal models of cirrhosis
JC Hoefs, T Morgan, BJ Ilagan
Digestive Diseases and Sciences 2011
Targeted TFO delivery to hepatic stellate cells
N Yang, S Singh, RI Mahato
Journal of Controlled Release 2011
The cardiorenal syndrome in heart failure: cardiac? renal? syndrome?
F Triposkiadis, RC Starling, H Boudoulas, G Giamouzis, J Butler
Heart Failure Reviews 2011
Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice*
Z Michailidou, S Turban, E Miller, X Zou, J Schrader, PJ Ratcliffe, PW Hadoke, BR Walker, JP Iredale, NM Morton, JR Seckl
The Journal of biological chemistry 2011
Tissue Inhibitor of Matrix-Metalloprotease–1 Predicts Risk of Hepatic Fibrosis in Human Schistosoma japonicum Infection
V Fabre, H Wu, S PondTor, H Coutinho, L Acosta, M Jiz, R Olveda, L Cheng, ES White, B Jarilla, ST McGarvey, JF Friedman, JD Kurtis
The Journal of Infectious Diseases 2011
TGF-β in progression of liver disease
S Dooley, P Dijke
Cell and Tissue Research 2011
Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure
H Ehlken, V Kondylis, J Heinrichsdorff, L Ochoa-Callejero, T Roskams, M Pasparakis
PloS one 2011
Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice
WI Jeong, O Park, YG Suh, JS Byun, SY Park, E Choi, JK Kim, H Ko, H Wang, AM Miller, B Gao
Hepatology 2011
Accelerated and Progressive and Lethal Liver Fibrosis in Mice that Lack Interleukin (IL)-10, IL-12p40, and IL-13R α2
MM Mentink-Kane, AW Cheever, MS Wilson, SK Madala, LM Beers, TR Ramalingam, T A.Wynn
Gastroenterology 2011
Pathogenesis and treatment of hepatic fibrosis: is cirrhosis reversible?
Fallowfield J, Hayes P
Clinical Medicine 2011
Neuropilin-1 Enhances PDGF and TGFβ Dependent Hepatic Stellate Cell Signaling Thereby Promoting Liver Cirrhosis
Sheng Cao, Usman Yaqoob, Amitava Das, Uday Shergill, Kumaravelu Jagavelu, Robert Huebert, Chittaranjan Routray, Soha Abdelmoneim, Meher Vasdev, Edward B. Leof, Michael R. Charlton, Ryan Watts, Debabrata Mukhopadhyay, Vijay Shah
Journal of Clinical Investigation 2010
Antagonism of the chemokine Ccl5 (Rantes) ameliorates experimental liver fibrosis in mice
Marie-Luise Berres, Rory Koenen, Anna Rueland, Mirko Moreno Zaldivar, Daniel Heinrichs, Hacer Sahin, Petra Schmitz, Konrad Streetz, Thomas Berg, Nikolaus Gaßler, Ralf Weiskirchen, Amanda Proudfoot, Christian Weber, Christian Trautwein, Hermann E. Wasmuth
Journal of Clinical Investigation 2010
Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis
A Moles, N Tarrats, A Morales, M Domínguez, R Bataller, J Caballería, C García-Ruiz, JC Fernández-Checa, M Marí
The American Journal of Pathology 2010
PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
C Montfort, JI Beier, JP Kaiser, L Guo, S Joshi-Barve, MT Pritchard, JC States, GE Arteel
American journal of physiology. Gastrointestinal and liver physiology 2010
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice
VE de Meijer, DY Sverdlov, Y Popov, HD Le, JA Meisel, V Nosé, D Schuppan, M Puder
PloS one 2010
Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
Y Popov, DY Sverdlov, KR Bhaskar, AK Sharma, G Millonig, E Patsenker, S Krahenbuhl, L Krahenbuhl, D Schuppan
American journal of physiology. Gastrointestinal and liver physiology 2010
Macrophages: master regulators of inflammation and fibrosis
TA Wynn, L Barron
Seminars in liver disease 2010
14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway
DN Roy, S Mandal, G Sen, S Mukhopadhyay, T Biswas
British Journal of Pharmacology 2010
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
E Hintermann, M Bayer, JM Pfeilschifter, AD Luster, U Christen
Journal of Autoimmunity 2010
Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo
JX Jiang, S Venugopal, N Serizawa, X Chen, F Scott, Y Li, R Adamson, S Devaraj, V Shah, ME Gershwin, SL Friedman, NJ Török
Gastroenterology 2010
Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
HW Zimmermann, S Seidler, J Nattermann, N Gassler, C Hellerbrand, A Zernecke, JJ Tischendorf, T Luedde, R Weiskirchen, C Trautwein, F Tacke
PloS one 2010
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
J Mann, DC Chu, A Maxwell, F Oakley, NL Zhu, H Tsukamoto, DA Mann
Gastroenterology 2010
Combinatorial gene therapy renders increased survival in cirrhotic rats
FJ Gálvez-Gastélum, AA Segura-Flores, MD Senties-Gomez, JF Muñoz-Valle, JS Armendáriz-Borunda
Journal of Biomedical Science 2010
Advances in Alcoholic Liver Disease
JI Beier, GE Arteel, CJ McClain
Current Gastroenterology Reports 2010
Evolving challenges in hepatic fibrosis
SL Friedman
Nature Reviews Gastroenterology & Hepatology 2010
Decreased collagen types I and IV, laminin, CK-19 and α-SMA expression after bone marrow cell transplantation in rats with liver fibrosis
SN Carvalho, DC Lira, GP Oliveira, AA Thole, AC Stumbo, CE Caetano, RG Marques, L Carvalho
Histochemistry and Cell Biology 2010
Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis
CS Schaffert, MJ Duryee, RG Bennett, AL DeVeney, DJ Tuma, P Olinga, KC Easterling, GM Thiele, LW Klassen
AJP Gastrointestinal and Liver Physiology 2010
Pathophysiologie der Leberfibrose: Aktuelle Aspekte und neue Ansätze für antifibrotische Therapien
F Tacke, R Weiskirchen
Der Internist 2010
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
A Moles, N Tarrats, JC Fernández-Checa, M Marí
Hepatology 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production
A Omenetti, WK Syn, Y Jung, H Francis, A Porrello, RP Witek, SS Choi, L Yang, MJ Mayo, ME Gershwin, G Alpini, AM Diehl
Hepatology 2009
Pathogenesis of non-alcoholic fatty liver disease
JK Dowman, JW Tomlinson, PN Newsome
QJM 2009
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture
Z Xu, FJ Castellino, VA Ploplis
Blood 2009
CCR2 promotes hepatic fibrosis in mice
E Seki, S Minicis, S Inokuchi, K Taura, K Miyai, N Rooijen, RF Schwabe, DA Brenner
Hepatology 2009
Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice
C Mitchell, D Couton, JP Couty, M Anson, AM Crain, V Bizet, L Rénia, S Pol, V Mallet, H Gilgenkrantz
The American Journal of Pathology 2009
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
F Zijl, M Mair, A Csiszar, D Schneller, G Zulehner, H Huber, R Eferl, H Beug, H Dolznig, W Mikulits
Oncogene 2009
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
O Park, WI Jeong, L Wang, H Wang, ZX Lian, ME Gershwin, B Gao
Hepatology 2009
Suppressive Effect of Orthovanadate on Hepatic Stellate Cell Activation and Liver Fibrosis in Rats
Y Nishikawa, N Ohi, A Yagisawa, Y Doi, Y Yamamoto, M Yoshida, T Tokairin, T Yoshioka, Y Omori, K Enomoto
The American Journal of Pathology 2009
Epithelial–mesenchymal transition in hepatocellular carcinoma
F Zijl, G Zulehner, M Petz, D Schneller, C Kornauth, M Hau, G Machat, M Grubinger, H Huber, W Mikulits
Future Oncology 2009
Hepatic wound repair
M Parola, M Pinzani
Fibrogenesis & Tissue Repair 2009
Surgical inflammation: a pathophysiological rainbow
JI Arias, MA Aller, J Arias
Journal of Translational Medicine 2009
Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease
J Marsillach, J Camps, N Ferré, R Beltran, A Rull, B Mackness, M Mackness, J Joven
BMC Gastroenterology 2009
Hepatic Stellate Cell-Specific Gene Silencing Induced by an Artificial MicroRNA for Antifibrosis In Vitro
Y Chang, H Jiang, X Sun, X Cai, X He, P Li, W Tang, Y Song, J Lin
Digestive Diseases and Sciences 2009
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis
X Ma, L Xu, S Wang, H Chen, J Xu, X Li, G Ning
Laboratory Investigation 2009
Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology
F Joanna, V Mathieu, S Sarah, D Sarah, V Karin, V Tamara, R Vera
Journal of Cellular and Molecular Medicine 2009
Hepatic fibrosis
Jiao J, Friedman SL, Aloman C
Current Opinion in Gastroenterology 2009
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola
Fibrogenesis & Tissue Repair 2008
Cellular and molecular mechanisms of fibrosis
TA Wynn
The Journal of Pathology 2008
Mechanisms of Hepatic Fibrogenesis
SL Friedman
Gastroenterology 2008
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
SL Friedman
Physiological reviews 2008
Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells
JN Artaza, KC Norris
Journal of Endocrinology 2008
Fibrogenesis of parenchymal organs
T Kisseleva, DA Brenner
Proceedings of the American Thoracic Society 2008
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
C Henegar, J Tordjman, V Achard, D Lacasa, I Cremer, M Guerre-Millo, C Poitou, A Basdevant, V Stich, N Viguerie, D Langin, P Bedossa, JD Zucker, K Clement
Genome biology 2008
Immune Interactions in Hepatic Fibrosis
AP Holt, M Salmon, CD Buckley, DH Adams
Clinics in Liver Disease 2008
Experimental obstructive cholestasis: the wound-like inflammatory liver response
MA Aller, JL Arias, J García-Domínguez, JI Arias, M Durán, J Arias
Fibrogenesis & Tissue Repair 2008
Innate immunity and alcoholic liver fibrosis
WI Jeong, B Gao
Journal of Gastroenterology and Hepatology 2008
Vascular biology and pathobiology of the liver: Report of a single-topic symposium
Y Iwakiri, M Grisham, V Shah
Hepatology 2008
Keratin Mutation Predisposes to Mouse Liver Fibrosis and Unmasks Differential Effects of the Carbon Tetrachloride and Thioacetamide Models
P Strnad, GZ Tao, Q Zhou, M Harada, DM Toivola, EM Brunt, MB Omary
Gastroenterology 2008
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
WI Jeong, O Park, B Gao
Gastroenterology 2008
Hepatitis C and innate immunity: recent advances
G Szabo, A Dolganiuc
Clinics in Liver Disease 2008
The liver pharmacological and xenobiotic gene response repertoire
G Natsoulis, CI Pearson, J Gollub, BP Eynon, J Ferng, R Nair, R Idury, MD Lee, MR Fielden, RJ Brennan, AH Roter, K Jarnagin
Molecular Systems Biology 2008
Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications.
Preziosi L, Tosin A
Journal of Mathematical Biology 2008
Common and Unique Mechanisms Regulate Fibrosis in Various Fibroproliferative Diseases
Thomas A. Wynn
Journal of Clinical Investigation 2007
Holeuryhalinity and its mechanisms in a cirriped crustacean, Balanus improvisus.
Fyhn HJ
Comparative Biochemistry and Physiology Part A Physiology 1976

← Previous 1 2 … 14 15 16 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 19 patents
556 readers on Mendeley
1 readers on CiteULike
See more details