Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.
John P. Iredale
Title and authors | Publication | Year |
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Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells
Wang Z, Yuan M, Yao L, Xiong Z, Dai K, Liu P, Chen P, Sun M, Shu K, Xia Y, Jiang Y |
Journal of Nanobiotechnology | 2025 |
Study on the mechanism of hsa_circ_0074763 regulating the miR-3667-3P/ACSL4 axis in liver fibrosis
Cheng Y, Song T, Yao J, Wang Q, Meng C, Feng F |
Scientific Reports | 2025 |
cPLA2α on the influence of Th17 and its role in the formation of liver fibrosis
Ma L, Wang W, Gu L, Wang L |
Cytotechnology | 2025 |
Towards novel liver injury therapies based on design, synthesis and therapeutic efficacy of novel sulfone bis-compound on liver necrosis
Rashdan HR, Hassan S, Maher S, Okasha H |
Scientific Reports | 2025 |
The Wnt/β-Catenin Inhibitor HC-1 Suppresses Liver Fibrosis by Inhibiting Activated Hepatic Stellate Cells and Inducing Matrix Metalloproteinase-1
Hatakeyama D, Itaba N, Shimizu H, Morimoto M, Shiota G |
Yonago Acta Medica | 2025 |
Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis
Zhang C, Ma H, DeRoche D, Gale EM, Pantazopoulos P, Rotile NJ, Diyabalanage H, Humblet V, Caravan P, Zhou IY |
npj Imaging | 2025 |
Identification and validation of the fibrosis-related molecular subtypes of hepatocellular carcinoma by bioinformatics
Liu LL, Cao WL, Chen JS, Wang JP |
Discover Oncology | 2025 |
Artificial Intelligence in Liver Diseases: Recent Advances.
Lu F, Meng Y, Song X, Li X, Liu Z, Gu C, Zheng X, Jing Y, Cai W, Pinyopornpanish K, Mancuso A, Romeiro FG, Méndez-Sánchez N, Qi X |
Advances in Therapy | 2024 |
A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation
Atia MM, Mahmoud HA, Wilson M, Abd-Allah EA |
Heliyon | 2024 |
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities.
Diwan R, Gaytan SL, Bhatt HN, Pena-Zacarias J, Nurunnabi M |
Drug Delivery and Translational Research | 2024 |
Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system
Zhao BW, Chen YJ, Zhang RP, Chen YM, Huang BW |
World Journal of Gastroenterology | 2024 |
Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis.
Li D, Yang W, Pang J, Yu G |
Molecular Biology Reports | 2024 |
Radiofrequency ablation versus microwave ablation for hepatocellular carcinoma with cirrhosis: a propensity score analysis
Xiong Y, Zhang Y, Hu C |
Translational cancer research | 2024 |
Exportin 4 DNA promoter methylation in liver fibrosis
Pan Z, Bayoumi A, Metwally M, George J, Eslam M |
PloS one | 2024 |
Assessing the combined impact of fatty liver-induced TGF-β1 and LPS-activated macrophages in fibrosis through a novel 3D serial section methodology
Ishiyama S, Hayatsu M, Toriumi T, Tsuda H, Watanabe K, Kasai H, Kishigami S, Mochizuki K, Mikami Y |
Scientific Reports | 2024 |
Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis: Should we consider further implications?
Barone M |
World Journal of Gastroenterology | 2024 |
Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles
Elmorsy EA, Saber S, Kira AY, Alghasham A, Abdel-Hamed MR, Amer MM, Mohamed EA, AlSalloom A. A, Alkhamiss AS, Hamad RS, Abdel-Reheim MA, Ellethy AT, Elsisi HA, Alsharidah M, Elghandour SR, Elnawawy T, Abdelhady R |
Frontiers in pharmacology | 2024 |
Boiling histotripsy exhibits anti-fibrotic effects in animal models of liver fibrosis
Joung C, Heo J, Pahk KJ, Pahk K |
Scientific Reports | 2024 |
Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells
Chen L, Ye X, Yang L, Zhao J, You J, Feng Y |
2024 | |
Liver Fibrosis: From Basic Science towards Clinical Progress, Focusing on the Central Role of Hepatic Stellate Cells
Akkız H, Gieseler RK, Canbay A |
International journal of molecular sciences | 2024 |
Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations
Liu Q, Wang S, Fu J, Chen Y, Xu J, Wei W, Song H, Zhao X, Wang H |
Clinical and Translational Medicine | 2024 |
New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?
Tagliaferro M, Marino M, Basile V, Pocino K, Rapaccini GL, Ciasca G, Basile U, Carnazzo V |
Journal of Personalized Medicine | 2024 |
Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis
Setyawati DR, Sekaringtyas FC, Pratiwi RD, Rosyidah A, Azhar R, Gustini N, Syahputra G, Rosidah I, Mardliyati E, Tarwadi, El Muttaqien S |
Beilstein Journal of Nanotechnology | 2024 |
Potential mechanisms of traditional Chinese medicine in the treatment of liver cirrhosis: a focus on gut microbiota
Sun S, Zhang G, Lv S, Sun J |
Frontiers in Microbiology | 2024 |
Exploring hepatic fibrosis screening via deep learning analysis of tongue images
Lu XZ, Hu HT, Li W, Deng JF, Chen LD, Cheng MQ, Huang H, Ke WP, Wang W, Sun BG |
Journal of Traditional and Complementary Medicine | 2024 |
Wharton's Jelly mesenchymal stem cell‐derived extracellular vesicles induce liver fibrosis‐resolving phenotype in alternatively activated macrophages
Torabi S, Zarrabi M, Shekari F, Poorkazem H, Lotfinia M, Bencina S, Gramignoli R, Hassan M, Najimi M, Vosough M |
Journal of Cellular and Molecular Medicine | 2024 |
Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism.
Li X, Liu Y, Tang Y, Xia Z |
Frontiers in immunology | 2024 |
Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders
Selc M, Macova R, Babelova A |
Drug Design, Development and Therapy | 2024 |
Clinical implications of the latest advances in gastrointestinal tumor research
Dai W, Li YQ, Zhou Y |
World Journal of Gastrointestinal Oncology | 2024 |
Mechanisms of Metal-Induced Hepatic Inflammation.
Subramaniam NK, Mann KK |
Current environmental health reports | 2024 |
Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis
Zhang C, Ma H, DeRoche D, Gale EM, Pantazopoulos P, Rotile NJ, Diyabalanage H, Humblet V, Caravan P, Zhou IY |
Research Square | 2024 |
Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard
Charoenchue P, Khorana J, Chitapanarux T, Inmutto N, Na Chiangmai W, Amantakul A, Pojchamarnwiputh S, Tantraworasin A |
Diagnostics | 2024 |
Unveiling the role of Pafah1b3 in liver fibrosis: A novel mechanism revealed
Lin L, Yang S, Li X, Zhang W, Zheng J |
Journal of Pharmaceutical Analysis | 2024 |
m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs
Dai X, Cheng Y, Luo W, Wang J, Wang C, Zhang X, Zhang W, Chao J |
Small Science | 2024 |
Neuroblastoma RAS viral oncogene homolog (N-RAS) exerts a cytoprotective effect in liver injury
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José Regueiro, Eduardo Martínez-Naves, Mohamed Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Gines, Andreea Ciudin, Jesús Rivera-Esteban, Juan Pericàs, María Frutos, Bruno Molina, José Herranz, Matías Ávila, Yulia Nevzorova, Edgar Fernández-Malavé, Francisco Cubero |
Cell Death and Disease | 2023 |
Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis
Li L, Zhu Z |
Frontiers in pharmacology | 2023 |
Identification of key genes related to immune infiltration in cirrhosis via bioinformatics analysis
Du TY, Gao YX, Zheng YS |
Scientific Reports | 2023 |
Liver immunity, autoimmunity, and inborn errors of immunity
Parlar YE, Ayar SN, Cagdas D, Balaban YH |
World journal of hepatology | 2023 |
Influence of ursodeoxycholic acid on blood glucose, insulin and GLP-1 in rats with liver fibrosis induced by bile duct ligation
Bai XP, Du WJ, Xing HB, Yang GH, Bai R |
Diabetology & metabolic syndrome | 2023 |
A standardized pomegranate fruit extract ameliorates thioacetamide-induced liver fibrosis in rats via AGE-RAGE-ROS signaling.
Abouelezz HM, Shehatou GSG, Shebl AM, Salem HA |
Heliyon | 2023 |
Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells
Lin CY, Mamani UF, Guo Y, Liu Y, Cheng K |
Biomolecules | 2023 |
DHEA and Its Metabolites Reduce the Cytokines Involved in the Inflammatory Response and Fibrosis in Primary Biliary Cholangitis
Blatkiewicz M, Sielatycka K, Piotrowska K, Kilańczyk E |
International journal of molecular sciences | 2023 |
Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics
Singh S, Sharma N, Shukla S, Behl T, Gupta S, Anwer MK, Vargas-De-La-Cruz C, Bungau SG, Brisc C |
Molecules (Basel, Switzerland) | 2023 |
The hepatoprotective effect of aspirin on carbon tetrachloride‑induced hepatic fibrosis via inhibition of TGFβ‑1 pathway and pro‑inflammatory cytokines IL‑1β and COX‑2 in rats
Wu Z, Wu Y, Zhong W, Zhong Q, Rao S, Yu D, Luo X, Qiu F, Song Z, Jin D, Ai M, Lan Y, Zhang G, Song S, Xie B, Sun S |
Experimental and therapeutic medicine | 2023 |
Can Vitamin D Levels Alter the Effectiveness of Short-Term Facelift Interventions?
Trifan DF, Tirla AG, Moldovan AF, Moș C, Bodog F, Maghiar TT, Manole F, Ghitea TC |
Healthcare | 2023 |
Hepatic inflammatory responses in liver fibrosis.
Hammerich L, Tacke F |
Nature reviews. Gastroenterology & hepatology | 2023 |
Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis
Ha KB, Lee ES, Park NW, Jo SH, Shim S, Kim DK, Ahn CM, Chung CH |
Diabetes & Metabolism Journal | 2023 |
Friend or foe? The elusive role of hepatic stellate cells in liver cancer.
Cogliati B, Yashaswini CN, Wang S, Sia D, Friedman SL |
Nature reviews. Gastroenterology & hepatology | 2023 |
In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations.
Lee YS, Seki E |
Cellular and Molecular Gastroenterology and Hepatology | 2023 |
Correlation between SDF-1α, CD34 positive hematopoietic stem cells and CXCR4 expression with liver fibrosis in CCl4 rat model.
Abubakr S, Hazem NM, Sherif RN, Elhawary AA, Botros KG |
BMC Gastroenterology | 2023 |
Isolation and Biological Evaluation of Alfa-Mangostin as Potential Therapeutic Agents against Liver Fibrosis
Liao YJ, Lee CY, Twu YC, Suk FM, Lai TC, Chang YC, Lai YC, Yuan JW, Jhuang HM, Jian HR, Huang LC, Chen KP, Hsu MH |
Bioengineering | 2023 |
Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
Hijazi N, Shi Z, Rockey DC |
Journal of cell science | 2023 |
Inflammatory signaling in NASH driven by hepatocyte mitochondrial dysfunctions
Myint M, Oppedisano F, De Giorgi V, Kim BM, Marincola FM, Alter HJ, Nesci S |
Journal of Translational Medicine | 2023 |
Suppressed Histone H3 Lysine 18 Acetylation Is Involved in Arsenic-Induced Liver Fibrosis in Rats by Triggering the Dedifferentiation of Liver Sinusoidal Endothelial Cells
Hu F, Zhou X, Peng Q, Ma L |
Toxics | 2023 |
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation
Pan Q, Gao M, Kim D, Ai W, Yang W, Jiang W, Brashear W, Dai Y, Li S, Sun Y, Qi Y, Guo S |
Cellular and Molecular Gastroenterology and Hepatology | 2023 |
The Origin and Fate of Liver Myofibroblasts
Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T |
Cellular and Molecular Gastroenterology and Hepatology | 2023 |
Antifibrotic Effect of Selenium-Containing Nanoparticles on a Model of TAA-Induced Liver Fibrosis
Varlamova EG, Goltyaev MV, Rogachev VV, Gudkov SV, Karaduleva EV, Turovsky EA |
Cells | 2023 |
Programmed cell death in hepatic fibrosis: current and perspectives.
Lu JL, Yu CX, Song LJ |
Cell Death Discovery | 2023 |
The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration.
Deshmukh K, Apte U |
Seminars in liver disease | 2023 |
Gut Microbiome and Organ Fibrosis
C Costa, B Sampaio-Maia, R Araujo, D Nascimento, J Ferreira-Gomes, M Pestana, M Azevedo, I Alencastre |
Nutrients | 2022 |
Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora.
Liu X, Wang L, Tan S, Chen Z, Wu B, Wu X |
Frontiers in pharmacology | 2022 |
Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.
Islam R, Kundu S, Jha SB, Rivera AP, Flores Monar GV, Islam H, Puttagunta SM, Sange I |
Cureus | 2022 |
Mouse Models of Liver Parenchyma Injuries and Regeneration
Du Y, Zhang W, Qiu H, Xiao C, Shi J, Reid LM, He Z |
Frontiers in Cell and Developmental Biology | 2022 |
Quantitative ultrasound, elastography, and machine learning for assessment of steatosis, inflammation, and fibrosis in chronic liver disease
Destrempes F, Gesnik M, Chayer B, Roy-Cardinal MH, Olivié D, Giard JM, Sebastiani G, Nguyen BN, Cloutier G, Tang A |
PloS one | 2022 |
The macrophage-associated microRNA-4715-3p / Gasdermin D axis potentially indicates fibrosis progression in nonalcoholic fatty liver disease: evidence from transcriptome and biological data
Chen S, Cai X, Liu Y, Shen Y, Guillot A, Tacke F, Tang L, Liu H |
Bioengineered | 2022 |
Treatment of Liver Fibrosis: A 20-Year Bibliometric and Knowledge-Map Analysis
Dai YK, Zhao ZM, Liu C |
Frontiers in pharmacology | 2022 |
Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease.
He X, Liu T, Zhang R, Li X |
Genetics Research | 2022 |
Comparison of spin-echo echo-planar imaging magnetic resonance elastography with gradient-recalled echo magnetic resonance elastography and their correlation with transient elastography.
Yoon JW, Lee ES, Park HJ, Park SB, Cho YY, Kannengiesser S, Hur J |
2022 | |
Anti-liver fibrosis activity of curcumin/chitosan-coated green silver nanoparticles.
Elzoheiry A, Ayad E, Omar N, Elbakry K, Hyder A |
Scientific Reports | 2022 |
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L |
Cells | 2022 |
Current Perspectives of Neuroendocrine Regulation in Liver Fibrosis
Li B, Wang H, Zhang Y, Liu Y, Zhou T, Zhou B, Zhang Y, Chen R, Xing J, He L, Salinas JM, Koyama S, Meng F, Wan Y |
Cells | 2022 |
Insights into Manganese Superoxide Dismutase and Human Diseases
Liu M, Sun X, Chen B, Dai R, Xi Z, Xu H |
International journal of molecular sciences | 2022 |
Novel potential biomarkers for severe alcoholic liver disease
Huang J, Yu J, Wang J, Liu J, Xie W, Li R, Wang C |
Frontiers in immunology | 2022 |
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment
Ning Y, Zhou IY, Roberts JD Jr, Rotile NJ, Akam E, Barrett SC, Sojoodi M, Barr MN, Punshon T, Pantazopoulos P, Drescher HK, Jackson BP, Tanabe KK, Caravan P |
Science Translational Medicine | 2022 |
Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy.
Li H, Liu T, Yang Y, Cho WC, Flynn RJ, Harandi MF, Song H, Luo X, Zheng Y |
Genes & Diseases | 2022 |
Differential recruitment of monocyte-derived macrophages in control and stellate cell-depleted mice during recurrent carbon tetrachloride-induced acute liver injury.
Sharma A, Kudira R, Wang J, Miethke A, Gandhi CR |
Journal of Cellular Physiology | 2022 |
Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations
D Heinrichs, EF Brandt, P Fischer, J Köhncke, TH Wirtz, N Guldiken, S Djudjaj, P Boor, D Kroy, R Weiskirchen, R Bucala, HE Wasmuth, P Strnad, C Trautwein, J Bernhagen, ML Berres |
Cells | 2021 |
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Y Wu, Y Cao, K Xu, Y Zhu, Y Qiao, Y Wu, J Chen, C Li, R Zeng, G Ge |
Cell Death and Disease | 2021 |
Liver regeneration and inflammation: from fundamental science to clinical applications
L Campana, H Esser, M Huch, S Forbes |
Nature Reviews Molecular Cell Biology | 2021 |
HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
X Xie, H Lv, C Liu, X Su, Z Yu, S Song, H Bian, M Tian, C Qin, J Qi, Q Zhu |
BMC Medicine | 2021 |
Anti-fibrotic treatments for chronic liver diseases: The present and the future
N Odagiri, T Matsubara, M Sato-Matsubara, H Fujii, M Enomoto, N Kawada |
Clinical and Molecular Hepatology | 2021 |
Natural Progression of Non-Alcoholic Steatohepatitis to Hepatocellular Carcinoma
D Ramai, W Tai, M Rivera, A Facciorusso, N Tartaglia, M Pacilli, A Ambrosi, C Cotsoglou, R Sacco |
Biomedicines | 2021 |
Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration
F Arnold, PU Mahaddalkar, JM Kraus, X Zhong, W Bergmann, D Srinivasan, J Gout, E Roger, AK Beutel, E Zizer, U Tharehalli, N Daiss, R Russell, L Perkhofer, R Oellinger, Q Lin, N Azoitei, FU Weiss, MM Lerch, S Liebau, SF Katz, A Lechel, R Rad, T Seufferlein, HA Kestler, M Ott, AD Sharma, PC Hermann, A Kleger |
Advanced Science | 2021 |
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol‐associated liver disease
J Chen, R MartinMateos, J Li, Z Yin, J Chen, X Lu, KJ Glaser, T Mounajjed, H Yashiro, J Siegelman, CT Winkelmann, J Wang, RL Ehman, VH Shah, M Yin |
Alcoholism, clinical and experimental research | 2021 |
Fibroblast growth factor receptor 3 in hepatocytes protects from toxin-induced liver injury and fibrosis
AE Fearon, CF Slabber, A Kuklin, M Bachofner, L Tortola, L Pohlmeier, S Pantasis, T Hornemann, L Chen, M Kopf, S Werner |
iScience | 2021 |
Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways
Z Li, Z Wang, F Dong, W Shi, W Dai, J Zhao, Q Li, Z Fang, L Ren, T Liu, Z Wei, W Mou, L Lin, Y Yang, X Xiao, L Ma, Z Bai |
Frontiers in pharmacology | 2021 |
Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis
JH Yoon, JM Lee, MH Yu, BY Hur, R Grimm, S Sourbron, H Chandarana, Y Son, S Basak, KB Lee, NJ Yi, KW Lee, KS Suh |
European Radiology | 2021 |
Patterns of dendritic cell and monocyte subsets are associated with disease severity and mortality in liver cirrhosis patients
CC Cardoso, C Matiollo, CH Pereira, JS Fonseca, HE Alves, OM da Silva, V de Souza Menegassi, CR dos Santos, AC de Moraes, L de Lucca Schiavon, MC Santos-Silva |
Scientific Reports | 2021 |
Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
P Mukherjee, A Miyazawa, S Fukuda, T Yamashita, D Lukmanto, K Okada, IA El-Sadek, L Zhu, S Makita, T Oshika, Y Yasuno |
Scientific Reports | 2021 |
Efficacy and Safety of Emricasan in Liver Cirrhosis and/or Fibrosis
L Mu, S Li, L Tang, R Li |
Clinics | 2021 |
Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice
F Momen-Heravi, D Catalano, A Talis, G Szabo, S Bala |
Molecular Therapy — Nucleic Acids | 2021 |
Modulation of Liver Inflammation and Fibrosis by Interleukin-37
S Mountford, M Effenberger, H Noll-Puchta, L Griessmair, A Ringleb, S Haas, G Denk, FP Reiter, D Mayr, CA Dinarello, H Tilg, P Bufler |
Frontiers in immunology | 2021 |
Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs
S Fumoto, T Yamamoto, K Okami, Y Maemura, C Terada, A Yamayoshi, K Nishida |
Pharmaceutics | 2021 |
Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor
FK El-Baz, A Salama, SI Ali, R Elgohary, AM Attar |
BioMed Research International | 2021 |
Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis
S Pu, Y Li, Q Liu, X Zhang, L Chen, R Li, J Zhang, T Wu, Q Tang, X Yang, Z Zhang, Y Huang, J Kuang, H Li, M Zou, W Jiang, J He |
Frontiers in pharmacology | 2021 |
Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
C Lee, M Kim, J Han, M Yoon, Y Jung |
Biomedicines | 2021 |
Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis
A Charchanti, P Kanavaros, E Koniaris, A Kataki, G Glantzounis, NJ Agnantis, AC Goussia |
In vivo (Athens, Greece) | 2021 |
Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
M Migdał, E Tralle, KA Nahia, Ł Bugajski, KZ Kędzierska, F Garbicz, K Piwocka, CL Winata, M Pawlak |
BMC Genomics | 2021 |
The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis
H Fuji, G Miller, T Nishio, Y Koyama, K Lam, V Zhang, R Loomba, D Brenner, T Kisseleva |
Frontiers in Molecular Biosciences | 2021 |
Engineering and Monitoring 3D Cell Constructs with Time-Evolving Viscoelasticity for the Study of Liver Fibrosis In Vitro.
Cacopardo L, Ahluwalia A |
2021 | |
A narrative review of liver regeneration—from models to molecular basis
Huang W, Han N, Du L, Wang M, Chen L, Tang H |
Annals of translational medicine | 2021 |
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
N Roehlen, E Crouchet, TF Baumert |
Cells | 2020 |
Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis
CY Lee, FM Suk, YC Twu, YJ Liao |
International journal of environmental research and public health | 2020 |
Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice
XY Xu, Y Du, X Liu, Y Ren, Y Dong, HY Xu, JS Shi, D Jiang, X Xu, L Li, ZH Xu, Y Geng |
Cell Communication and Signaling | 2020 |
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner |
Nature Reviews Gastroenterology & Hepatology | 2020 |
Role of TGF‑β1‑mediated epithelial‑mesenchymal transition in the pathogenesis of tympanosclerosis
J Qiu, Y Wang, W Guo, L Xu, Y Mou, L Cui, F Han, Y Sun |
Experimental and therapeutic medicine | 2020 |
The Endothelium as a Driver of Liver Fibrosis and Regeneration
E Lafoz, M Ruart, A Anton, A Oncins, V Hernández-Gea |
Cells | 2020 |
Pro- and Anti-fibrogenic Functions of Gram-Negative Bacterial Lipopolysaccharide in the Liver
CR Gandhi |
Frontiers in Medicine | 2020 |
Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair
L da Silva Meirelles, RF Marson, MI Solari, NB Nardi |
Cells | 2020 |
[18F]- Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis
T Shao, Z Chen, V Belov, X Wang, SH Rwema, V Kumar, H Fu, X Deng, J Rong, Q Yu, L Lang, W Lin, L Josephson, AE Samir, X Chen, RT Chung, SH Liang |
Journal of Hepatology | 2020 |
Mechanisms of liver fibrosis and its role in liver cancer
D Dhar, J Baglieri, T Kisseleva, DA Brenner |
Experimental biology and medicine (Maywood, N.J.) | 2020 |
Lipid nanoparticle technology for therapeutic gene regulation in the liver
D Witzigmann, JA Kulkarni, J Leung, S Chen, PR Cullis, R van der Meel |
Advanced Drug Delivery Reviews | 2020 |
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats
W Li, C Zhou, Y Fu, T Chen, X Liu, Z Zhang, T Gong |
Acta pharmaceutica Sinica. B | 2020 |
Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis
J Zhang, ES Muise, S Han, PS Kutchukian, P Costet, Y Zhu, Y Kan, H Zhou, V Shah, Y Huang, A Saigal, TE Akiyama, XL Shen, TQ Cai, K Shah, E Carballo-Jane, E Zycband, L Yi, Y Tian, Y Chen, J Imbriglio, E Smith, K Devito, J Conway, LJ Ma, M Hoek, IK Sebhat, AM Peier, S Talukdar, DG McLaren, SF Previs, KK Jensen, S Pinto |
Reproduction | 2020 |
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against Decapentaplegic, and CCAAT/Enhancer‐Binding Protein C/EBP Transcription Factors
A Sharma, AK Verma, M Kofron, R Kudira, A Miethke, T Wu, J Wang, CR Gandhi |
Hepatology | 2020 |
Fuzheng Huayu Capsule Attenuates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells
M Wu, Y Zhou, SL Qin, LJ Lin, J Ping, Z Tao, J Zhang, LM Xu, J Wu |
Evidence-Based Complementary and Alternative Medicine | 2020 |
Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models
BL Li, JJ Hu, JD Xie, C Ni, HJ Liang, QR Li, J Yuan, JW Wu, J Wan |
Evidence-Based Complementary and Alternative Medicine | 2020 |
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway
Z Wang, ZX Cheng, ST Abrams, ZQ Lin, ED Yates, Q Yu, WP Yu, PS Chen, CH Toh, GZ Wang |
World journal of gastroenterology : WJG | 2020 |
Intravenous Umbilical Cord-derived Mesenchymal Stem Cells Transplantation Regulates Hyaluronic Acid and Interleukin-10 Secretion Producing Low-grade Liver Fibrosis in Experimental Rat.
Sungkar T, Putra A, Lindarto D, Sembiring RJ |
2020 | |
Upregulation of C-Reactive Protein by Placenta-Derived Mesenchymal Stem Cells Promotes Angiogenesis in A Rat Model with Cirrhotic Liver.
Jun JH, Jung J, Kim JY, Hwang SG, Bae SH, Kim GJ |
International journal of stem cells | 2020 |
TGF-β1 accelerates the hepatitis B virus X-induced malignant transformation of hepatic progenitor cells by upregulating miR-199a-3p
K Dong, Y Chen, G Yang, Z Liao, H Zhang, H Liang, X Chen, H Dong |
Oncogene | 2019 |
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
B Hinz, D Lagares |
Nature Reviews Rheumatology | 2019 |
Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice
ZY Chang, CC Chen, HM Liu, YC Yeh, TY Lin, TY Lee, TH Huang |
International journal of molecular sciences | 2019 |
Mechanisms for the Resolution of Organ Fibrosis
JC Horowitz, VJ Thannickal |
Physiology (Bethesda, Md.) | 2019 |
A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
RE Sharkawy, A Bayoumi, M Metwally, A Mangia, T Berg, M Romero-Gomez, ML Abate, WL Irving, D Sheridan, GJ Dore, U Spengler, P Lampertico, E Bugianesi, M Weltman, L Mollison, W Cheng, S Riordan, R Santoro, R Gallego-Durán, J Fischer, J Nattermann, R DAmbrosio, D McLeod, E Powell, O latchoumanin, K Thabet, MA Najim, MW Douglas, C Liddle, L Qiao, J George, M Eslam |
Scientific Reports | 2019 |
MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H+ Transporting V1 Subunit C1
F Jing, Y Geng, XY Xu, HY Xu, JS Shi, ZH Xu |
International journal of molecular sciences | 2019 |
MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation
YH Huang, HC Kuo, YL Yang, FS Wang |
International journal of medical sciences | 2019 |
AICD: an integrated anti-inflammatory compounds database for drug discovery
K Wang, J Xiao, X Liu, Z Jiang, Y Zhan, T Yin, L He, F Zhang, S Xing, B Chen, Y Li, F Zhang, Z Kuang, B Du, J Gu |
Scientific Reports | 2019 |
Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model
MR Park, MS Wong, MJ Araúzo-Bravo, H Lee, D Nam, SY Park, HD Seo, SM Lee, HF Zeilhofer, H Zaehres, HR Schöler, JB Kim, LA van Grunsven |
PloS one | 2019 |
A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation
MD Muthiah, DQ Huang, L Zhou, NH Jumat, M Choolani, JK Chan, A Wee, SG Lim, YY Dan |
Scientific Reports | 2019 |
Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis
N JalanSakrikar, TM Assuncao, G Shi, SO Aseem, C Chi, VH Shah, RC Huebert |
Hepatology | 2019 |
Validation of Novel Fibrosis Index (NFI) for assessment of liver fibrosis: comparison with transient elastography (FibroScan)
A Hussain, MA Gul, MU Khalid |
BMJ Open Gastroenterology | 2019 |
Prospective comparison of transient, point shear wave, and magnetic resonance elastography for staging liver fibrosis
T Lefebvre, C Wartelle-Bladou, P Wong, G Sebastiani, JM Giard, H Castel, J Murphy-Lavallée, D Olivié, A Ilinca, MP Sylvestre, G Gilbert, ZH Gao, BN Nguyen, G Cloutier, A Tang |
European Radiology | 2019 |
Level and Value of T Cell-derived Circulating Microparticles in Liver Cirrhosis Patients
CHEN CH, CHANG CL, CHEN KH, CHENG BC, CHEN HH, CHIANG JY, SUNG PH, YIP HK |
In vivo (Athens, Greece) | 2019 |
Pathological changes of liver one year later in CHB patients with negative HBV DNA
Shanshan W, Xinfang D, Shuihong Y, Kecong L, Jinjin Q, Zhi C, Feng C |
Infectious agents and cancer | 2019 |
KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation.
Legaz I, Bolarín JM, Navarro E, Campillo JA, Moya R, Pérez-Cárceles MD, Luna A, Osuna E, Miras M, Muro M, Minguela A, Alvarez López R |
Archives of Medical Science : AMS | 2019 |
Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis.
Hu P, Sun J, Lv F, Pi B, Xu F, Han G, Hu X, Wang Y, Huang N, Wu X, Yang X |
2019 | |
Role of Hepatic Deposited Immunoglobulin G in the Pathogenesis of Liver Damage in Systemic Lupus Erythematosus
X Fang, MH Zaman, X Guo, H Ding, C Xie, X Zhang, GM Deng |
Frontiers in immunology | 2018 |
Combatting Fibrosis: Exosome‐Based Therapies in the Regression of Liver Fibrosis
L Chen, DA Brenner, T Kisseleva |
Hepatology Communications | 2018 |
PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis
Y Yang, X Wu, W Li, H Huang, H Li, X Pan, X Li, C Huang, X Meng, L Zhang, X Lv, H Wang, J Li |
Oncogene | 2018 |
Emerging Role of HMGB1 in the Pathogenesis of Schistosomiasis Liver Fibrosis
AR Vicentino, VC Carneiro, D Allonso, R de Freitas Guilherme, CF Benjamim, HA dos Santos, F Xavier, A dos Santos Pyrrho, J de Assis Silva Gomes, M de Castro Fonseca, RC de Oliveira, TA Pereira, L Ladislau, JR Lambertucci, MR Fantappié |
Frontiers in immunology | 2018 |
Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis
M Praktiknjo, J Lehmann, MJ Nielsen, R Schierwagen, FE Uschner, C Meyer, D Thomas, CP Strassburg, F Bendtsen, S Møller, A Krag, MA Karsdal, DJ Leeming, J Trebicka |
Hepatology Communications | 2018 |
Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling
C Balta, A Ciceu, H Herman, M Rosu, OM Boldura, A Hermenean |
Dose-Response | 2018 |
Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility
JI Fortea, C Fernández-Mena, M Puerto, C Ripoll, J Almagro, J Bañares, JM Bellón, R Bañares, J Vaquero |
Scientific Reports | 2018 |
Flavanones from Sedum sarmentosum Bunge Alleviate CCl 4 -Induced Liver Fibrosis in Rats by Targeting TGF- β 1/T β R/Smad Pathway In Turn Inhibiting Epithelial Mesenchymal Transition
Y Lin, H Luo, X Wang, M Zheng, Q Jin, H Chen, P Pan, J Zhang |
Evidence-Based Complementary and Alternative Medicine | 2018 |
Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts
R Weiskirchen, S Weiskirchen, F Tacke |
F1000Research | 2018 |
Evaluation of Plasma Urokinase-Type Plasminogen Activator Receptor (UPAR) in Patients With Chronic Hepatitis B, C and Non-Alcoholic Fatty Liver Disease (NAFLD) as Serological Fibrosis Marker
Ö Akdoğan, AA Yücel, ZG Sargin, C Sönmez, GE Yilmaz, S Özenirler |
Journal of Clinical and Experimental Hepatology | 2018 |
Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review
NX Hoan, HV Tong, LH Song, CG Meyer, TP Velavan |
World journal of gastroenterology : WJG | 2018 |
Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study
NM El-Lakkany, WH El-Maadawy, SH el-Din, S Saleh, MM Safar, SM Ezzat, SH Mohamed, SS Botros, Z Demerdash, OA Hammam |
Journal of traditional and complementary medicine | 2018 |
Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism)
M Khatami |
Clinical and Translational Medicine | 2018 |
Liver function tests in identifying patients with liver disease
Z Ahmed, U Ahmed, S Walayat, J Ren, DK Martin, H Moole, S Koppe, S Yong, S Dhillon |
Clinical and experimental gastroenterology | 2018 |
Accumulation of citrullinated glial fibrillary acidic protein in a mouse model of bile duct ligation-induced hepatic fibrosis
SE Kim, JW Park, MJ Kim, B Jang, YC Jeon, HJ Kim, A Ishigami, HS Kim, KT Suk, DJ Kim, CK Park, EK Choi, MK Jang, LA van Grunsven |
PloS one | 2018 |
Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis
S Al-Fayoumi, T Hashiguchi, Y Shirakata, J Mascarenhas, JW Singer |
Journal of Experimental Pharmacology | 2018 |
Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice
D Yuan, T Xiang, Y Huo, C Liu, T Wang, Z Zhou, Y Dun, H Zhao, C Zhang |
Archives of Medical Science : AMS | 2018 |
CM-101: Type I Collagen–targeted MR Imaging Probe for Detection of Liver Fibrosis
CT Farrar, EM Gale, R Kennan, I Ramsay, R Masia, G Arora, K Looby, L Wei, J Kalpathy-Cramer, MM Bunzel, C Zhang, Y Zhu, TE Akiyama, M Klimas, S Pinto, H Diyabalanage, KK Tanabe, V Humblet, BC Fuchs, P Caravan |
Radiology | 2018 |
Molecular Characterization of a Precision-Cut Rat Liver Slice Model for the Evaluation of Anti-Fibrotic Compounds
X Huang, H Cai, R Ammar, Y Zhang, Y Wang, K Ravi, JR Thompson, G Jarai |
AJP Gastrointestinal and Liver Physiology | 2018 |
Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies
S Cannito, C Milani, A Cappon, M Parola, M Strazzabosco, M Cadamuro |
International journal of molecular sciences | 2018 |
Universal Index for Cirrhosis (UIC index): The development and validation of a novel index to predict advanced liver disease
Z Ahmed, J Ren, A Gonzalez, U Ahmed, S Walayat, DK Martin, H Moole, S Yong, S Koppe, S Dhillon |
Hepatic medicine : evidence and research | 2018 |
Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat
Aliasghar Parvaresh Anbar, Tayyebeh Piran, Mehrdad Farhadi, Pouran Karimi |
Iranian Journal of Basic Medical Sciences | 2018 |
Liver fibrosis
MM Aydin, KC Akcali |
TURK J GASTROENTEROL | 2018 |
Quantitative ultrasound and machine learning for assessment of steatohepatitis in a rat model.
Tang A, Destrempes F, Kazemirad S, Garcia-Duitama J, Nguyen BN, Cloutier G |
European Radiology | 2018 |
Platelets prime hematopoietic–vascular niche to drive angiocrine-mediated liver regeneration
K Shido, D Chavez, Z Cao, JL Ko, S Rafii, BS Ding |
Signal Transduction and Targeted Therapy | 2017 |
Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis
CX Cai, H Buddha, S Castelino-Prabhu, Z Zhang, RS Britton, BR Bacon, BA Neuschwander-Tetri |
Digestive Diseases and Sciences | 2017 |
Direct orthotopic implantation of hepatic organoids
VX Zhou, M Lolas, TT Chang |
Journal of Surgical Research | 2017 |
Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging
A Müller, K Hochrath, J Stroeder, K Hittatiya, G Schneider, F Lammert, A Buecker, P Fries |
BioMed Research International | 2017 |
Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis
ME de França, SW Rocha, WH Oliveira, LA Santos, AG de Oliveira, KP Barbosa, AK Nunes, GB Rodrigues, DB Lós, CA Peixoto |
Inflammopharmacology | 2017 |
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis
MJ Bollong, B Yang, N Vergani, BA Beyer, EN Chin, C Zambaldo, D Wang, AK Chatterjee, LL Lairson, PG Schultz |
Proceedings of the National Academy of Sciences | 2017 |
Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis
V Prestigiacomo, A Weston, S Messner, F Lampart, L Suter-Dick, P Mukhopadhyay |
PloS one | 2017 |
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
HD Singh, I Otano, K Rombouts, KP Singh, D Peppa, US Gill, K Böttcher, PT Kennedy, J Oben, M Pinzani, H Walczak, G Fusai, WM Rosenberg, MK Maini |
Scientific Reports | 2017 |
Differentiation of fibrotic liver tissue using laser-induced breakdown spectroscopy
E Teran-Hinojosa, H Sobral, C Sánchez-Pérez, A Pérez-García, N Alemán-García, J Hernández-Ruiz |
Biomedical Optics Express | 2017 |
eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet
WG Choi, J Han, JH Kim, MJ Kim, JW Park, B Song, HJ Cha, HS Choi, HT Chung, IK Lee, TS Park, M Hatzoglou, HS Choi, HJ Yoo, RJ Kaufman, SH Back |
Nutrition & Metabolism | 2017 |
β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis
Y Wang, AM Terrell, BA Riggio, D Anand, SA Lachke, MK Duncan |
Investigative ophthalmology & visual science | 2017 |
Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats
KH Lu, CY Weng, WC Chen, LY Sheen |
Journal of Ginseng Research | 2017 |
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
N Ikenaga, ZW Peng, KA Vaid, SB Liu, S Yoshida, DY Sverdlov, A Mikels-Vigdal, V Smith, D Schuppan, YV Popov |
Gut | 2017 |
IL-33-ST2 Axis in Liver Disease: Progression and Challenge
Z Sun, B Chang, M Gao, J Zhang, Z Zou |
Mediators of Inflammation | 2017 |
Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial
PN Newsome, R Fox, AL King, D Barton, NN Than, J Moore, C Corbett, S Townsend, J Thomas, K Guo, D Hull, HA Beard, J Thompson, A Atkinson, C Bienek, N McGowan, N Guha, J Campbell, D Hollyman, D Stocken, C Yap, SJ Forbes |
The Lancet Gastroenterology & Hepatology | 2017 |
The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology
X Ou, S Mao, J Cao, Y Ma, G Ma, A Cheng, M Wang, D Zhu, S Chen, R Jia, M Liu, K Sun, Q Yang, Y Wu, X Chen |
Oncotarget | 2017 |
Hepatic Fibrosis in Dogs
VM Eulenberg, JA Lidbury |
Journal of Veterinary Internal Medicine | 2017 |
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis
VS Athwal, J Pritchett, J Llewellyn, K Martin, E Camacho, SM Raza, A PhythianAdams, LJ Birchall, AF Mullan, K Su, L Pearmain, G Dolman, AM Zaitoun, SL Friedman, A MacDonald, WL Irving, IN Guha, NA Hanley, KP Hanley |
EMBO Molecular Medicine | 2017 |
Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
F Yang, L Luo, ZD Zhu, X Zhou, Y Wang, J Xue, J Zhang, X Cai, ZL Chen, Q Ma, YF Chen, YJ Wang, YY Luo, P Liu, L Zhao |
Frontiers in pharmacology | 2017 |
IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.
Eslam M, McLeod D, Kelaeng KS, Mangia A, Berg T, Thabet K, Irving WL, Dore GJ, Sheridan D, Grønbæk H, Abate ML, Hartmann R, Bugianesi E, Spengler U, Rojas A, Booth DR, Weltman M, Mollison L, Cheng W, Riordan S, Mahajan H, Fischer J, Nattermann J, Douglas MW, Liddle C, Powell E, Romero-Gomez M, George J |
Nature Genetics | 2017 |
Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease
BM McGettigan, RH McMahan, Y Luo, XX Wang, DJ Orlicky, C Porsche, M Levi, HR Rosen |
The Journal of biological chemistry | 2016 |
Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases
S Li, M Hong, HY Tan, N Wang, Y Feng |
Oxidative medicine and cellular longevity | 2016 |
Versican: a novel modulator of hepatic fibrosis
TN Bukong, SB Maurice, B Chahal, DF Schaeffer, PJ Winwood |
Laboratory Investigation | 2016 |
Role of thrombospondin 1 in liver diseases: TSP1 in liver disease
Y Li, CP Turpin, S Wang |
Hepatology Research | 2016 |
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice
LN Chow, P Schreiner, BY Ng, B Lo, MR Hughes, RW Scott, V Gusti, S Lecour, E Simonson, I Manisali, I Barta, KM McNagny, J Crawford, M Webb, TM Underhill, P Mukhopadhyay |
PloS one | 2016 |
Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with 99mTc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice
D Zhang, Z Guo, P Zhang, Y Li, X Su, L You, M Gao, C Liu, H Wu, X Zhang |
Scientific Reports | 2016 |
A potential role for genome structure in the translation of mechanical force during immune cell development
E Jacobson, JK Perry, DS Long, MH Vickers, JM O'Sullivan |
Nucleus | 2016 |
Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury
P Rantakari, DA Patten, J Valtonen, M Karikoski, H Gerke, H Dawes, J Laurila, S Ohlmeier, K Elima, SG Hübscher, CJ Weston, S Jalkanen, DH Adams, M Salmi, S Shetty |
Proceedings of the National Academy of Sciences | 2016 |
Adverse outcome pathway development from protein alkylation to liver fibrosis
T Horvat, B Landesmann, A Lostia, M Vinken, S Munn, M Whelan |
Archives of Toxicology | 2016 |
Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury
AJ Paris, Y Liu, J Mei, N Dai, L Guo, LA Spruce, KM Hudock, JS Brenner, WJ Zacharias, HD Mei, AR Slamowitz, K Bhamidipati, MF Beers, SH Seeholzer, EE Morrisey, GS Worthen |
American journal of physiology. Lung cellular and molecular physiology | 2016 |
Biomarker-Based Approaches for Assessing Alcohol Use Disorders
O Niemelä |
International journal of environmental research and public health | 2016 |
The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis
D Karin, Y Koyama, D Brenner, T Kisseleva |
Differentiation | 2016 |
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
KA Lytle, DB Jump, H Guillou |
PloS one | 2016 |
Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis
E Hintermann, M Bayer, J Ehser, M Aurrand-Lions, JM Pfeilschifter, BA Imhof, U Christen |
Cell adhesion & migration | 2016 |
Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
YC Twu, TS Lee, YL Lin, SM Hsu, YH Wang, CY Liao, CK Wang, YC Liang, YJ Liao |
International journal of molecular sciences | 2016 |
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis
M Rezvani, R Español-Suñer, Y Malato, L Dumont, AA Grimm, E Kienle, JG Bindman, E Wiedtke, BY Hsu, SJ Naqvi, RF Schwabe, CU Corvera, D Grimm, H Willenbring |
Cell Stem Cell | 2016 |
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ3 for staging liver fibrosis in rat model
DB Wang, C Zhang, H Liu, Y Cui, X Li, Z Zhang, Y Zhang |
International Journal of Nanomedicine | 2016 |
Mechanocompatible Polymer-Extracellular-Matrix Composites for Vascular Tissue Engineering
B Jiang, R Suen, JJ Wang, ZJ Zhang, JA Wertheim, GA Ameer |
Advanced Healthcare Materials | 2016 |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
K Thabet, A Asimakopoulos, M Shojaei, M Romero-Gomez, A Mangia, WL Irving, T Berg, GJ Dore, H Grønbæk, D Sheridan, ML Abate, E Bugianesi, M Weltman, L Mollison, W Cheng, S Riordan, J Fischer, U Spengler, J Nattermann, A Wahid, A Rojas, R White, MW Douglas, D McLeod, E Powell, C Liddle, D der Poorten, J George, M Eslam, R Gallego-Duran, T Applegate, M Bassendine, C Rosso, L Mezzabotta, R Leung, B Malik, G Matthews, J Grebely, V Fragomeli, JR Jonsson, R Santaro |
Nature Communications | 2016 |
Pentoxifylline inhibits liver fibrosis via hedgehog signaling pathway
H Li, J Hua, C Guo, W Wang, B Wang, D Yang, P Wei, Y Lu |
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2016 |
A deleterious role for Th9/IL-9 in hepatic fibrogenesis
S Qin, D Lu, X Guo, W Luo, B Hu, X Huang, M Chen, J Wang, SJ Ma, X Yang, H Jiang, Y Zhou |
Scientific Reports | 2016 |
Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia: Matrix metalloproteinases in biliary atresia
A Kerola, H Lampela, J Lohi, P Heikkilä, A Mutanen, J Hagström, T Tervahartiala, T Sorsa, C Haglund, H Jalanko, MP Pakarinen |
The Journal of Pathology: Clinical Research | 2016 |
The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig: Placental insufficiency and LBW, Western diet and fibrosis
O Sarr, A Blake, JA Thompson, L Zhao, K Rabicki, JC Walsh, I Welch, TR Regnault |
The Journal of Physiology | 2016 |
Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
HT Schon, M Bartneck, E Borkham-Kamphorst, J Nattermann, T Lammers, F Tacke, R Weiskirchen |
Frontiers in pharmacology | 2016 |
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis
N Fransén-Pettersson, N Duarte, J Nilsson, M Lundholm, S Mayans, Å Larefalk, TD Hannibal, L Hansen, A Schmidt-Christensen, F Ivars, S Cardell, R Palmqvist, B Rozell, D Holmberg, MA Avila |
PloS one | 2016 |
Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease?
W Seo |
World journal of gastroenterology : WJG | 2016 |
The antifibrotic and fibrolytic properties of date fruit extract via modulation of genotoxicity, tissue-inhibitor of metalloproteinases and nuclear factor- kappa B pathway in a rat model of hepatotoxicity
H Attia, N Al-Rasheed, R Mohamad, N Al-Rasheed, M Al-Amin |
BMC complementary and alternative medicine | 2016 |
Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells
S Bi, F Chu, M Wang, B Li, P Mao, H Zhang, P Wang, W Guo, L Xu, L Ren, H Lei, Y Zhang |
Molecules (Basel, Switzerland) | 2016 |
Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model: Zhu et al
B Zhu, L Wei, N Rotile, H Day, T Rietz, CT Farrar, GY Lauwers, KK Tanabe, B Rosen, BC Fuchs, P Caravan |
Hepatology | 2016 |
Novel therapeutic targets in primary biliary cirrhosis
JK Dyson, GM Hirschfield, DH Adams, U Beuers, DA Mann, KD Lindor, DE Jones |
Nature Reviews Gastroenterology & Hepatology | 2015 |
The role of TGFβ1 and LRG1 in cardiac remodelling and heart failure
W Song, X Wang |
Biophysical Reviews | 2015 |
Epithelial–Mesenchymal Transition in Kidney Tubular Epithelial Cells Induced by Globotriaosylsphingosine and Globotriaosylceramide
YJ Jeon, N Jung, JW Park, HY Park, SC Jung, JW Lee |
PloS one | 2015 |
Substrate-specific gene expression profiles in different kidney cell types are associated with Fabry disease
YJ Shin, Y Jeon, N Jung, JW Park, HY Park, SC Jung |
Molecular medicine reports | 2015 |
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva |
Experimental biology and medicine (Maywood, N.J.) | 2015 |
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
KE Kim, H Kim, RW Heo, HJ Shin, C Yi, DH Lee, HJ Kim, SS Kang, GJ Cho, WS Choi, GS Roh |
The Korean Journal of Physiology & Pharmacology | 2015 |
Identifying Molecular Targets to Improve Immune Function in Alcoholic Hepatitis
R Bataller, P Mandrekar |
Gastroenterology | 2015 |
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M
JA Richards, M Bucsaiova, EE Hesketh, C Ventre, NC Henderson, K Simpson, CO Bellamy, SE Howie, SM Anderton, J Hughes, SJ Wigmore, CM Stover |
PloS one | 2015 |
Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis
S Amara, K Lopez, B Banan, SK Brown, M Whalen, E Myles, MT Ivy, T Johnson, KL Schey, V Tiriveedhi |
Molecular Immunology | 2015 |
Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF- β 1/Smad Signaling
N Lu, Y Liu, A Tang, L Chen, D Miao, X Yuan |
BioMed Research International | 2015 |
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
M Eslam, AM Hashem, R Leung, M Romero-Gomez, T Berg, GJ Dore, HL Chan, WL Irving, D Sheridan, ML Abate, LA Adams, A Mangia, M Weltman, E Bugianesi, U Spengler, O Shaker, J Fischer, L Mollison, W Cheng, E Powell, J Nattermann, S Riordan, D McLeod, NJ Armstrong, MW Douglas, C Liddle, DR Booth, J George, G Ahlenstiel, J Ampuero, M Bassendine, VW Wong, C Rosso, R White, L Mezzabotta, V Suppiah, M Michalk, B Malik, G Matthews, T Applegate, J Grebely, V Fragomeli, JR Jonsson, R Santaro |
Nature Communications | 2015 |
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice
TR Harris, A Bettaieb, S Kodani, H Dong, R Myers, N Chiamvimonvat, FG Haj, BD Hammock |
Toxicology and Applied Pharmacology | 2015 |
Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor- β 1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats
NM Al-Rasheed, HA Attia, RA Mohamad, NM Al-Rasheed, MA Al-Amin, A AL-Onazi |
Evidence-Based Complementary and Alternative Medicine | 2015 |
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Hussein M Atta |
World journal of gastroenterology : WJG | 2015 |
Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury
Bo Liang, Xiao-Ling Guo, Jing Jin, Yong-Chun Ma, Zheng-Quan Feng |
World journal of gastroenterology : WJG | 2015 |
Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions
A Tang, G Cloutier, NM Szeverenyi, CB Sirlin |
AJR. American journal of roentgenology | 2015 |
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels
R Weiskirchen, A Mahli, S Weiskirchen, C Hellerbrand |
Frontiers in physiology | 2015 |
Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface
S Xu, CH Kang, X Gou, Q Peng, J Yan, S Zhuo, CL Cheng, Y He, Y Kang, W Xia, PT So, R Welsch, JC Rajapakse, H Yu |
Journal of Biophotonics | 2015 |
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
MJ Nielsen, J Lehmann, DJ Leeming, R Schierwagen, S Klein, C Jansen, CP Strassburg, F Bendtsen, S Møller, T Sauerbruch, MA Karsdal, A Krag, J Trebicka |
Digestive Diseases and Sciences | 2015 |
Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice
M Ganz, TN Bukong, T Csak, B Saha, JK Park, A Ambade, K Kodys, G Szabo |
Journal of Translational Medicine | 2015 |
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CT Farrar, DK DePeralta, H Day, TA Rietz, L Wei, GY Lauwers, B Keil, A Subramaniam, AJ Sinskey, KK Tanabe, BC Fuchs, P Caravan |
Journal of Hepatology | 2015 |
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice
L Ye, H Yu, C Li, ML Hirsch, L Zhang, RJ Samulski, W Li, Z Liu, X Meng |
PloS one | 2015 |
Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo
Y Wang, X Zhang, Y Yang, X Yang, B Ye |
Marine drugs | 2015 |
Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver: Liver Biology/Pathobiology
HW Zimmermann, T Bruns, CJ Weston, SM Curbishley, E Liaskou, KK Li, YJ Resheq, PW Badenhorst, DH Adams |
Hepatology | 2015 |
Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
CS Nowell, PD Odermatt, L Azzolin, S Hohnel, EF Wagner, GE Fantner, MP Lutolf, Y Barrandon, S Piccolo, F Radtke |
Nature Cell Biology | 2015 |
Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps
KA Bailey, AH Smith, EJ Tokar, JH Graziano, KW Kim, P Navasumrit, M Ruchirawat, A Thiantanawat, WA Suk, RC Fry |
Environmental Health Perspectives | 2015 |
Pathophysiology of Portal Hypertension
Morales-Ruiz M, Rodríguez-Vita J, Ribera J, Jiménez W |
PanVascular Medicine | 2015 |
Vascular Adhesion Protein-1 Promotes Liver Inflammation and Drives Hepatic Fibrosis
Chris Weston, Emma Shepherd, Lee Claridge, Pia rantakari, Stuart Curbishley, Jeremy Tomlinson, Stefan Hubscher, Gary Reynolds, Kristiina Aalto, Quentin Anstee, Sirpa Jalkanen, Marko Salmi, David Smith, Christopher Day, David Adams |
Journal of Clinical Investigation | 2014 |
IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice: HEPATOLOGY, Vol. XX, No. X, 2014
A Mitra, A Satelli, J Yan, X Xueqing, M Gagea, CA Hunter, L Mishra, S Li |
Hepatology | 2014 |
Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition
SJ Lee, KH Kim, KK Park |
World journal of hepatology | 2014 |
Evidence of endoplasmic reticulum stress and liver inflammation in the American mink Neovison vison with benign hepatic steatosis
K Rouvinen-Watt, C Pal, T Martin, L Harris, T Astatkie, D Kryzskaya, V Kärjä, AM Mustonen, R Tammi, M Tammi, P Nieminen |
Journal of Comparative Physiology B | 2014 |
Bone Marrow Stromal Cells Inhibit the Activation of Liver Cirrhotic Fat-Storing Cells via Adrenomedullin Secretion
X Wang, W Zhao, J Wang, K Shi, X Qin, Q Kong, G Wang, L Mu, H Li, B Sun, L Shi |
Digestive Diseases and Sciences | 2014 |
Virus-related liver cirrhosis: Molecular basis and therapeutic options
J Lin, JF Wu, Q Zhang, HW Zhang, GW Cao |
World journal of gastroenterology : WJG | 2014 |
Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans
L Beljaars, M Schippers, C Reker-Smit, FO Martinez, L Helming, K Poelstra, BN Melgert |
Frontiers in immunology | 2014 |
Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: Role of NADPH oxidase
M Wang, JM Abais, N Meng, Y Zhang, JK Ritter, PL Li, WX Tang |
Free radical biology & medicine | 2014 |
A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression
J Dutta-Moscato, A Solovyev, Q Mi, T Nishikawa, A Soto-Gutierrez, IJ Fox, Y Vodovotz |
Frontiers in Bioengineering and Biotechnology | 2014 |
FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells
Y Kong, H Wang, S Wang, N Tang |
Inflammation | 2014 |
Extracellular Matrix and Liver Disease
E Arriazu, MR de Galarreta, FJ Cubero, M Varela-Rey, MP de Obanos, TM Leung, A Lopategi, A Benedicto, I Abraham-Enachescu, N Nieto |
Antioxidants & Redox Signaling | 2014 |
Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation
X Yang, ZP Han, SS Zhang, PX Zhu, C Hao, TT Fan, Y Yang, L Li, YF Shi, LX Wei |
Cell Death and Disease | 2014 |
Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury
I Lua, D James, J Wang, KS Wang, K Asahina |
Hepatology | 2014 |
Difference in glycerol levels between leukemia and normal bone marrow stem cells
YS Qin, DX Bu, YY Cui, XY Zhang |
Oncology Letters | 2014 |
Resolvin E1 reduces hepatic fibrosis in mice with Schistosoma japonicum infection
W Qiu, K Guo, L Yi, Y Gong, L Huang, W Zhong |
Experimental and therapeutic medicine | 2014 |
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy
M Shen, K Chen, J Lu, P Cheng, L Xu, W Dai, F Wang, L He, Y Zhang, W Chengfen, J Li, J Yang, R Zhu, H Zhang, Y Zheng, Y Zhou, C Guo |
Mediators of Inflammation | 2014 |
Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update
GÖ Elpek |
World journal of gastroenterology : WJG | 2014 |
Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells
J Pritchett, VS Athwal, E Harvey, K Martin, J Llewellyn, P Ireland, A Nicolaides, MJ Humphries, N Bobola, NA Hanley, KP Hanley |
PloS one | 2014 |
Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis
K Sakai, S Jawaid, T Sasaki, G Bou-Gharios, T Sakai |
The American Journal of Pathology | 2014 |
Cell and tissue engineering for liver disease
SN Bhatia, GH Underhill, KS Zaret, IJ Fox |
Science Translational Medicine | 2014 |
Mutant MMP-9 and HGF Gene Transfer Enhance Resolution of CCl4-Induced Liver Fibrosis in Rats: Role of ASH1 and EZH2 Methyltransferases Repression
H Atta, M El-Rehany, O Hammam, H Abdel-Ghany, M Ramzy, M Roderfeld, E Roeb, A Al-Hendy, SA Raheim, H Allam, H Marey, MA Avila |
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Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF
M Bernard, M Dieudé, B Yang, K Hamelin, K Underwood, MJ Hébert |
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Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl 4 -) Induced Liver Injury in Mice
SW Rocha, ME de França, GB Rodrigues, KP Barbosa, AK Nunes, AF Pastor, AG Oliveira, WH Oliveira, RL Luna, CA Peixoto |
Mediators of Inflammation | 2014 |
Emerging role of HMGB1 in fibrotic diseases
LC Li, J Gao, J Li |
Journal of Cellular and Molecular Medicine | 2014 |
SHSST Cyclodextrin Complex Prevents the Fibrosis Effect on CCl4-Induced Cirrhotic Cardiomyopathy in Rats through TGF-β Pathway Inhibition Effects
CH Yang, WJ Ting, C Day, DT Ju, YL Yeh, LC Chung, FJ Tsai, CH Tsai, Y Tsai, CY Huang |
International journal of molecular sciences | 2014 |
Insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) contributes to liver inflammation and fibrosis via activation of the ERK1/2 pathway.
Guo Y, Zhang Y, Zhang Q, Guo X, Zhang H, Zheng G, Liu L |
Hepatology International | 2014 |
Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis
SC Beeman, LJ Mandarino, JF Georges, KM Bennett |
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 2013 |
Molecular MRI of collagen to diagnose and stage liver fibrosis
BC Fuchs, H Wang, Y Yang, L Wei, M Polasek, DT Schühle, GY Lauwers, A Parkar, AJ Sinskey, KK Tanabe, P Caravan |
Journal of Hepatology | 2013 |
A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
M Fujii, Y Shibazaki, K Wakamatsu, Y Honda, Y Kawauchi, K Suzuki, S Arumugam, K Watanabe, T Ichida, H Asakura, H Yoneyama |
Medical Molecular Morphology | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription
B Xu, SH Li, R Zheng, SB Gao, LH Ding, ZY Yin, X Lin, ZJ Feng, S Zhang, XM Wang, GH Jin |
Proceedings of the National Academy of Sciences | 2013 |
RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats
Z Luo, H Liu, X Sun, R Guo, R Cui, X Ma, M Yan |
PloS one | 2013 |
PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model
SJ Lee, JH Kang, SY Choi, KT Suk, DJ Kim, OS Kwon |
PloS one | 2013 |
Hepatic regeneration and the epithelial to mesenchymal transition
ZF Xue, XM Wu, M Liu |
World journal of gastroenterology : WJG | 2013 |
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
BS Ding, Z Cao, R Lis, DJ Nolan, P Guo, M Simons, ME Penfold, K Shido, SY Rabbany, S Rafii |
Nature | 2013 |
Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosis
S Cabrera, M Selman, A Lonzano-Bolaños, K Konishi, TJ Richards, N Kaminski, A Pardo |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
QM Anstee, G Targher, CP Day |
Nature Reviews Gastroenterology & Hepatology | 2013 |
Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure
MA Karsdal, MJ Nielsen, JM Sand, K Henriksen, F Genovese, AC Bay-Jensen, V Smith, JI Adamkewicz, C Christiansen, DJ Leeming |
ASSAY and Drug Development Technologies | 2013 |
Canine visceral leishmaniasis as a systemic fibrotic disease
LC Silva, RS Castro, MM Figueiredo, MS Michalick, WL Tafuri, WL Tafuri |
International Journal of Experimental Pathology | 2013 |
Contribution of Myofibroblasts of Different Origins to Liver Fibrosis
M Fausther, EG Lavoie, JA Dranoff |
Current Pathobiology Reports | 2013 |
Relaxin decreases the severity of established hepatic fibrosis in mice
RG Bennett, DG Heimann, S Singh, RL Simpson, DJ Tuma |
Liver International | 2013 |
Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts
X Liu, J Xu, DA Brenner, T Kisseleva |
Current Pathobiology Reports | 2013 |
The genetics of NAFLD
QM Anstee, CP Day |
Nature Reviews Gastroenterology & Hepatology | 2013 |
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis
P Mukhopadhyay, M Rajesh, Z Cao, B Horváth, O Park, H Wang, K Erdelyi, E Holovac, Y Wang, L Liaudet, N Hamdaoui, F Lafdil, G Haskó, C Szabo, AH Boulares, B Gao, P Pacher |
Hepatology | 2013 |
Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection
A Lamontagne, RE Long, MA Comunale, J Hafner, L Rodemich-Betesh, M Wang, J Marrero, AM di Bisceglie, T Block, A Mehta |
PloS one | 2013 |
From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence
G Ramakrishna, A Rastogi, N Trehanpati, B Sen, R Khosla, SK Sarin |
Liver Cancer | 2013 |
Fibrosis: a key feature of Fabry disease with potential therapeutic implications
F Weidemann, MD Sanchez-Niño, J Politei, JP Oliveira, C Wanner, DG Warnock, A Ortiz |
Orphanet Journal of Rare Diseases | 2013 |
In vivo X-ray computed tomographic imaging of soft tissue with native, intravenous, or oral contrast
CA Wathen, N Foje, T Avermaete, B Miramontes, SE Chapaman, TA Sasser, R Kannan, S Gerstler, WM Leevy |
Sensors (Basel, Switzerland) | 2013 |
High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK
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PloS one | 2013 |
Mutations in the catalytic domain of human matrix metalloproteinase-1 (MMP-1) that allow for regulated activity through the use of Ca2+
RD Paladini, G Wei, A Kundu, Q Zhao, LH Bookbinder, GA Keller, HM Shepard, GI Frost |
The Journal of biological chemistry | 2013 |
PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Induces Apoptosis of Activated Hepatic Stellate Cells in Vitro and in Vivo
D Parajuli, EJ Park, XH Che, WY Jiang, YC Kim, D Sohn, S Lee |
Molecules (Basel, Switzerland) | 2013 |
BML-11, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats.
Zhou XY, Yu ZJ, Yan D, Wang HM, Huang YH, Sha J, Xu FY, Cai ZY, Min WP |
Inflammation | 2013 |
Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism
JI Beier, GE Arteel |
Experimental biology and medicine (Maywood, N.J.) | 2012 |
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
ST Rashid, JD Humphries, A Byron, A Dhar, JA Askari, JN Selley, D Knight, RD Goldin, M Thursz, MJ Humphries |
Journal of Proteome Research | 2012 |
Reversibility of liver fibrosis
A Pellicoro, P Ramachandran, JP Iredale |
Fibrogenesis & Tissue Repair | 2012 |
IL-13 Signaling in Liver Fibrogenesis
Y Liu, S Munker, R Müllenbach, HL Weng |
Frontiers in immunology | 2012 |
Cell signals influencing hepatic fibrosis
M Cong, K Iwaisako, C Jiang, T Kisseleva |
International Journal of Hepatology | 2012 |
Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl4-Induced Acute Liver Injury
CC Chiu, CY Huang, TY Chen, SH Kao, JY Liu, YW Wang, BS Tzang, TC Hsu |
Evidence-based complementary and alternative medicine : eCAM | 2012 |
What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis: The origin of myofibroblasts
K Iwaisako, DA Brenner, T Kisseleva |
Journal of Gastroenterology and Hepatology | 2012 |
Liver fibrosis: a bidirectional model of fibrogenesis and resolution
P Ramachandran, JP Iredale |
QJM | 2012 |
Immunological Orchestration of Liver Fibrosis
H Tanaka, PS Leung, TP Kenny, ME Gershwin, CL Bowlus |
Clinical Reviews in Allergy & Immunology | 2012 |
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats
X Chen, C Liu, Y Lu, Z Yang, Z Lv, Q Xu, Q Pan, L Lu |
BMC complementary and alternative medicine | 2012 |
Global analysis of DNA methylation in early-stage liver fibrosis
Y Komatsu, T Waku, N Iwasaki, W Ono, C Yamaguchi, J Yanagisawa |
BMC Medical Genomics | 2012 |
MR T1ρ as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication
F Zhao, YX Wang, J Yuan, M Deng, HL Wong, ES Chu, MY Go, GJ Teng, AT Ahuja, J Yu |
European Radiology | 2012 |
Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate
Y Kim, MI Fiel, E Albanis, HI Chou, W Zhang, G Khitrov, SL Friedman |
Liver International | 2012 |
COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis
RP Favier, B Spee, BA Schotanus, TS van Ingh, H Fieten, B Brinkhof, CS Viebahn, LC Penning, J Rothuizen |
PloS one | 2012 |
Adipose derived mesenchymal stem cells transplantation via portal vein improves microcirculation and ameliorates liver fibrosis induced by CCl4 in rats
Y Wang, F Lian, J Li, W Fan, H Xu, X Yang, L Liang, W Chen, J Yang |
Journal of Translational Medicine | 2012 |
Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans
J Pritchett, E Harvey, V Athwal, A Berry, C Rowe, F Oakley, A Moles, DA Mann, N Bobola, AD Sharrocks, BJ Thomson, AM Zaitoun, WL Irving, IN Guha, NA Hanley, KP Hanley |
Hepatology | 2012 |
Prevalence and Importance of Comorbidities in Patients With Heart Failure
FK Triposkiadis, J Skoularigis |
Current Heart Failure Reports | 2012 |
Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside
F Zhang, D Kong, Y Lu, S Zheng |
Cellular and Molecular Life Sciences | 2012 |
Fibrogenic cell reversion underlies fibrosis regression in liver
SL Friedman |
Proceedings of the National Academy of Sciences | 2012 |
Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography
K Wahl, W Rosenberg, B Vaske, MP Manns, K Schulze-Osthoff, MJ Bahr, H Bantel |
PloS one | 2012 |
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats
Q Yao, B Xu, J Wang, H Liu, S Zhang, C Tu |
BMC complementary and alternative medicine | 2012 |
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models
M Polasek, BC Fuchs, R Uppal, DT Schühle, JK Alford, GS Loving, S Yamada, L Wei, GY Lauwers, AR Guimaraes, KK Tanabe, P Caravan |
Journal of Hepatology | 2012 |
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury.
Dulauroy S, Di Carlo SE, Langa F, Eberl G, Peduto L |
Nature Medicine | 2012 |
Prevention of Fibrosis Progression in CCl4-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems
Reichenbach V, Ros J, Fernández-Varo G, Casals G, Melgar-Lesmes P, Campos T, Makriyannis A, Morales-Ruiz M, Jiménez W |
The Journal of pharmacology and experimental therapeutics | 2012 |
Integrating mechanisms of pulmonary fibrosis
TA Wynn |
Journal of Experimental Medicine | 2011 |
Mesenchymal Cells of the Intestinal Lamina Propria
DW Powell, IV Pinchuk, JI Saada, X Chen, RC Mifflin |
Annual Review of Physiology | 2011 |
Innate immunity and PBC: Activated invariant NKT cells exacerbate murine autoimmune cholangitis and fibrosis
SJ Wu, YH Yang, K Tsuneyama, PS Leung, P Illarionov, ME Gershwin, YH Chuang |
Hepatology | 2011 |
Anti-fibrogenic Strategies and the regression of fibrosis
T Kisseleva, DA Brenner |
Best practice & research. Clinical gastroenterology | 2011 |
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
T Kisseleva, DA Brenner |
Journal of Hepatology | 2011 |
The lens as a model for fibrotic disease
JA Eldred, LJ Dawes, IM Wormstone |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2011 |
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
TR Cox, JT Erler |
Disease models & mechanisms | 2011 |
Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies
MH Ismail, M Pinzani |
Hepatic medicine : evidence and research | 2011 |
Accelerated CCl4-Induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression
G Sebastiani, K Gkouvatsos, C Maffettone, G Busatto, M Guido, K Pantopoulos |
PloS one | 2011 |
Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
HW Zimmermann, S Seidler, N Gassler, J Nattermann, T Luedde, C Trautwein, F Tacke |
PloS one | 2011 |
A Transgenic Model for Conditional Induction and Rescue of Portal Hypertension Reveals a Role of VEGF-Mediated Regulation of Sinusoidal Fenestrations
D May, V Djonov, G Zamir, M Bala, R Safadi, M Sklair-Levy, E Keshet |
PloS one | 2011 |
Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632
MM van Beuge, J Prakash, M Lacombe, E Post, C Reker-Smit, L Beljaars, K Poelstra |
Pharmaceutical Research | 2011 |
Testing beneficial therapy in human cirrhosis using animal models of cirrhosis
JC Hoefs, T Morgan, BJ Ilagan |
Digestive Diseases and Sciences | 2011 |
Targeted TFO delivery to hepatic stellate cells
N Yang, S Singh, RI Mahato |
Journal of Controlled Release | 2011 |
The cardiorenal syndrome in heart failure: cardiac? renal? syndrome?
F Triposkiadis, RC Starling, H Boudoulas, G Giamouzis, J Butler |
Heart Failure Reviews | 2011 |
Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice*
Z Michailidou, S Turban, E Miller, X Zou, J Schrader, PJ Ratcliffe, PW Hadoke, BR Walker, JP Iredale, NM Morton, JR Seckl |
The Journal of biological chemistry | 2011 |
Tissue Inhibitor of Matrix-Metalloprotease–1 Predicts Risk of Hepatic Fibrosis in Human Schistosoma japonicum Infection
V Fabre, H Wu, S PondTor, H Coutinho, L Acosta, M Jiz, R Olveda, L Cheng, ES White, B Jarilla, ST McGarvey, JF Friedman, JD Kurtis |
The Journal of Infectious Diseases | 2011 |
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S Dooley, P Dijke |
Cell and Tissue Research | 2011 |
Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure
H Ehlken, V Kondylis, J Heinrichsdorff, L Ochoa-Callejero, T Roskams, M Pasparakis |
PloS one | 2011 |
Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice
WI Jeong, O Park, YG Suh, JS Byun, SY Park, E Choi, JK Kim, H Ko, H Wang, AM Miller, B Gao |
Hepatology | 2011 |
Accelerated and Progressive and Lethal Liver Fibrosis in Mice that Lack Interleukin (IL)-10, IL-12p40, and IL-13R α2
MM Mentink-Kane, AW Cheever, MS Wilson, SK Madala, LM Beers, TR Ramalingam, T A.Wynn |
Gastroenterology | 2011 |
Pathogenesis and treatment of hepatic fibrosis: is cirrhosis reversible?
Fallowfield J, Hayes P |
Clinical Medicine | 2011 |
Neuropilin-1 Enhances PDGF and TGFβ Dependent Hepatic Stellate Cell Signaling Thereby Promoting Liver Cirrhosis
Sheng Cao, Usman Yaqoob, Amitava Das, Uday Shergill, Kumaravelu Jagavelu, Robert Huebert, Chittaranjan Routray, Soha Abdelmoneim, Meher Vasdev, Edward B. Leof, Michael R. Charlton, Ryan Watts, Debabrata Mukhopadhyay, Vijay Shah |
Journal of Clinical Investigation | 2010 |
Antagonism of the chemokine Ccl5 (Rantes) ameliorates experimental liver fibrosis in mice
Marie-Luise Berres, Rory Koenen, Anna Rueland, Mirko Moreno Zaldivar, Daniel Heinrichs, Hacer Sahin, Petra Schmitz, Konrad Streetz, Thomas Berg, Nikolaus Gaßler, Ralf Weiskirchen, Amanda Proudfoot, Christian Weber, Christian Trautwein, Hermann E. Wasmuth |
Journal of Clinical Investigation | 2010 |
Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis
A Moles, N Tarrats, A Morales, M Domínguez, R Bataller, J Caballería, C García-Ruiz, JC Fernández-Checa, M Marí |
The American Journal of Pathology | 2010 |
PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division
C Montfort, JI Beier, JP Kaiser, L Guo, S Joshi-Barve, MT Pritchard, JC States, GE Arteel |
American journal of physiology. Gastrointestinal and liver physiology | 2010 |
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice
VE de Meijer, DY Sverdlov, Y Popov, HD Le, JA Meisel, V Nosé, D Schuppan, M Puder |
PloS one | 2010 |
Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
Y Popov, DY Sverdlov, KR Bhaskar, AK Sharma, G Millonig, E Patsenker, S Krahenbuhl, L Krahenbuhl, D Schuppan |
American journal of physiology. Gastrointestinal and liver physiology | 2010 |
Macrophages: master regulators of inflammation and fibrosis
TA Wynn, L Barron |
Seminars in liver disease | 2010 |
14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway
DN Roy, S Mandal, G Sen, S Mukhopadhyay, T Biswas |
British Journal of Pharmacology | 2010 |
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
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Journal of Autoimmunity | 2010 |
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