JCI - Citations to The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

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The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

Claudia Scholl, … , D. Gary Gilliland, Stefan Fröhling

Claudia Scholl, … , D. Gary Gilliland, Stefan Fröhling

Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):1037-1048. https://doi.org/10.1172/JCI30182.

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Citations to this article (61)

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Aberrant stem cell and developmental programs in pediatric leukemia Ling RE, Cross JW, Roy A	Frontiers in Cell and Developmental Biology	2024
miR-133a and miR-135a Regulate All-Trans Retinoic Acid-Mediated Differentiation in Pediatric Acute Myeloid Leukemia by Inhibiting CDX2 Translation and Serve as Prognostic Biomarkers Cheng YC, Fan Z, Liang C, Peng CJ, Li Y, Wang LN, Luo JS, Zhang XL, Liu Y, Zhang LD	Technology in cancer research & treatment	2024
UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment Bastian L, Hartmann AM, Beder T, Hänzelmann S, Kässens J, Bultmann M, Hoeppner MP, Franzenburg S, Wittig M, Franke A, Nagel I, Spielmann M, Reimer N, Busch H, Schwartz S, Steffen B, Viardot A, Döhner K, Kondakci M, Wulf G, Wendelin K, Renzelmann A, Kiani A, Trautmann H, Neumann M, Gökbuget N, Brüggemann M, Baldus CD	Leukemia	2022
Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay T, Hunault M, Pflumio F, Freund JN, Lobry C, Lhéritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E	Blood	2022
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CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition A Galland, V Gourain, K Habbas, Y Güler, E Martin, C Ebel, M Tavian, L Vallat, MP Chenard, L Mauvieux, JN Freund, I Duluc, C DomonDell	Molecular Oncology	2021
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A Core Response to the CDX2 Homeoprotein During Development and in Pathologies V Gourain, I Duluc, C Domon-Dell, JN Freund	Frontiers in Genetics	2021
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The impact of Mir-9 regulation in normal and malignant hematopoiesis A Khosravi, S Alizadeh, A Jalili, R Shirzad, N Saki	Oncology Reviews	2018
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a BJ Shields, JT Jackson, D Metcalf, W Shi, Q Huang, AL Garnham, SP Glaser, D Beck, JE Pimanda, CW Bogue, GK Smyth, WS Alexander, MP McCormack	Genes & development	2016
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Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia BE Li, P Ernst	Experimental Hematology	2014
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Telomerase Inhibition Effectively Targets Mouse and Human AML Stem Cells and Delays Relapse following Chemotherapy C Bruedigam, FO Bagger, FH Heidel, C Paine Kuhn, S Guignes, A Song, R Austin, T Vu, E Lee, S Riyat, AS Moore, RB Lock, L Bullinger, GR Hill, SA Armstrong, DA Williams, SW Lane	Cell Stem Cell	2014
Transcriptional Regulation of the Intestinal Nuclear Bile Acid Farnesoid X Receptor (FXR) by the caudal-related Homeobox 2 (CDX2) S Modica, M Cariello, A Morgano, I Gross, MC Vegliante, S Murzilli, L Salvatore, JN Freund, C Sabba, A Moschetta	The Journal of biological chemistry	2014
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Hoxb8 regulates expression of microRNAs to control cell death and differentiation M Salmanidis, G Brumatti, N Narayan, BD Green, JA van Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert	Cell Death and Differentiation	2013
A Cdx4-Sall4 Regulatory Module Controls the Transition from Mesoderm Formation to Embryonic Hematopoiesis EJ Paik, S Mahony, RM White, EN Price, A DiBiase, B Dorjsuren, C Mosimann, AJ Davidson, D Gifford, LI Zon	Stem Cell Reports	2013
Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer Rouhi A, Fröhling S	Oncotarget	2013
Leukemogenesis by CDX2 involves KLF4 repression and deregulated PPARγ signaling Katrin Faber, Lars Bullinger, Christine Ragu, Angela Garding, Daniel Mertens, Christina Miller, Daniela Martin, Daniel Walcher, Konstanze Döhner, Hartmut Döhner, Rainer Claus, Christoph Plass, Stephen Sykes, Steven Lane, Claudia Scholl, Stefan Fröhling	Journal of Clinical Investigation	2012
Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis VP Rawat, RK Humphries, C Buske	Blood	2012
H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia M Kawahara, A Pandolfi, B Bartholdy, L Barreyro, B Will, M Roth, UC Okoye-Okafor, TI Todorova, ME Figueroa, A Melnick, CS Mitsiades, U Steidl	Cancer Cell	2012
Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma KB Nyquist, I Panagopoulos, J Thorsen, L Haugom, L Gorunova, B Bjerkehagen, A Fosså, M Guriby, T Nome, RA Lothe, RI Skotheim, S Heim, F Micci	PloS one	2012
Widespread over-expression of the non-clustered homeobox gene HLX in acute myeloid leukemia S Fröhling	Haematologica	2012
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HLX in AML: novel prognostic and therapeutic target Pandolfi A, Steidl U	Oncotarget	2012
Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish H Ro, IB Dawid	The EMBO Journal	2011
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Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells B Renouf, C Soret, T Saandi, F Delalande, E Martin, M Vanier, I Duluc, I Gross, JN Freund, C Domon-Dell	Nucleic Acids Research	2011
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GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis Z Wang, M Iwasaki, F Ficara, C Lin, C Matheny, SH Wong, KS Smith, ML Cleary	Cancer Cell	2010
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Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: Implications for a new canine leukemia model MS Thakar, XB Zhang, BC Beard, GE Sale, EB Santos, L Peterson, HP Kiem, BM Sandmaier	Experimental Hematology	2009
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis I Hofmann, EH Stover, DE Cullen, J Mao, KJ Morgan, BH Lee, MG Kharas, PG Miller, MG Cornejo, R Okabe, SA Armstrong, N Ghilardi, S Gould, FJ de Sauvage, AP McMahon, DG Gilliland	Cell Stem Cell	2009
Acute myeloid leukemia stem cells: seek and destroy GJ Roboz, M Guzman	Expert Review of Hematology	2009
Human BRE1 Is an E3 Ubiquitin Ligase for Ebp1 Tumor Suppressor Z Liu, SM Oh, M Okada, X Liu, D Cheng, J Peng, DJ Brat, S Sun, W Zhou, W Gu, K Ye, J Chernoff	Molecular biology of the cell	2009
Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, Yonekura Y, Fujibayashi Y	Cancer Science	2009
High-affinity neurotrophin receptors and ligands promote leukemogenesis Z Li, G Beutel, M Rhein, J Meyer, C Koenecke, T Neumann, M Yang, J Krauter, N Neuhoff, M Heuser, H Diedrich, G Göhring, L Wilkens, B Schlegelberger, A Ganser, C Baum	Blood	2008
Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes SL McKinney-Freeman, C Lengerke, IH Jang, S Schmitt, Y Wang, M Philitas, J Shea, GQ Daley	Blood	2008
Acute Myeloid Leukemia with a Complex Karyotype K Mrózek	Seminars in Oncology	2008
HOX deregulation in acute myeloid leukemia Kim L. Rice and Jonathan D. Licht	Journal of Clinical Investigation	2007
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells D Metcalf, S Glaser, S Mifsud, LD Rago, L Robb	Proceedings of the National Academy of Sciences	2007

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