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Citations to this article

Dependence of intestinal granuloma formation on unique myeloid DC-like cells
Atsushi Mizoguchi, … , Richard S. Blumberg, Atul K. Bhan
Atsushi Mizoguchi, … , Richard S. Blumberg, Atul K. Bhan
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):605-615. https://doi.org/10.1172/JCI30150.
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Research Article Immunology

Dependence of intestinal granuloma formation on unique myeloid DC-like cells

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Abstract

Granulomas represent a localized inflammatory reaction that is characteristically observed in many inflammatory conditions. However, the mechanisms of granuloma formation have not been fully defined. Herein we demonstrate, by using experimental models of intestinal inflammation, that a unique CD11c+ DC-like cell subset that exhibits phenotypic and functional features of immature myeloid DCs and is characterized by the expression of a macrophage marker (F4/80) produces large amounts of IL-23 and directly induces the development of granulomas under a Th1-predominant intestinal inflammatory condition. Importantly, both IL-4 and IgG contribute to the suppression of F4/80+ DC-like cell–mediated granuloma formation by regulating the function and differentiation of this cell subset. In addition, enteric flora is required for the F4/80+ DC-like cell–mediated granuloma formation. Collectively, our data provide what we believe are novel insights into the involvement of F4/80+ DC-like cells in intestinal granuloma formation and demonstrate the role of host (IL-4 and IgG) and environmental (enteric flora) factors that regulate this function.

Authors

Atsushi Mizoguchi, Atsushiro Ogawa, Hidetoshi Takedatsu, Ken Sugimoto, Yasuyo Shimomura, Katsunori Shirane, Kiyotaka Nagahama, Takashi Nagaishi, Emiko Mizoguchi, Richard S. Blumberg, Atul K. Bhan

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Total citations by year

Year: 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 1 1 4 4 5 2 4 2 23
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (4)

Title and authors Publication Year
A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3*
AM Smith, JE Qualls, K O'Brien, L Balouzian, PF Johnson, S Schultz-Cherry, ST Smale, PJ Murray
The Journal of biological chemistry 2011
Crohn disease: a current perspective on genetics, autophagy and immunity
TS Stappenbeck, JD Rioux, A Mizoguchi, T Saitoh, A Huett, A Darfeuille-Michaud, T Wileman, N Mizushima, S Carding, S Akira, M Parkes, RJ Xavier
Autophagy 2011
The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
A Nishida, CW Lau, M Zhang, A Andoh, HN Shi, E Mizoguchi, A Mizoguchi
Gastroenterology 2011
Crohn disease: A current perspective on genetics, autophagy and immunity
Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ
Autophagy 2011

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