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Citations to this article

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
F Fais, … , M Ferrarini, N Chiorazzi
F Fais, … , M Ferrarini, N Chiorazzi
Published October 15, 1998
Citation Information: J Clin Invest. 1998;102(8):1515-1525. https://doi.org/10.1172/JCI3009.
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Research Article Article has an altmetric score of 9

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

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Abstract

To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain insight into the potential role of antigenic stimulation in the development and diversification of these cells, we analyzed the rearranged VH genes expressed by 83 B-CLL cells (64 IgM+ and 19 non-IgM+). Our results confirm and extend the observations of a bias in the use of certain VH, D, and JH genes among B-CLL cells. In addition, they indicate that the VH genes of approximately 50% of the IgM+ B-CLL cells and approximately 75% of the non-IgM+ B-CLL cells can exhibit somatic mutations. The presence of mutation varies according to the VH family expressed by the B-CLL cell (VH3 expressers displaying more mutation than VH1 and VH4 expressers). In addition, the extent of mutation can be sizeable with approximately 32% of the IgM+ cases and approximately 68% of the non-IgM+ cases differing by > 5% from the most similar germline gene. Approximately 20% of the mutated VH genes display replacement mutations in a pattern consistent with antigen selection. However, CDR3 characteristics (D and JH gene use and association and HCDR3 length, composition, and charge) suggest that selection for distinct B cell receptors (BCR) occurs in many more B-CLL cells. Based on these data, we suggest three prototypic BCR, representing the VH genes most frequently encountered in our study. These data suggest that many B-CLL cells have been previously stimulated, placing them in the "experienced" or "memory" CD5(+) B cell subset.

Authors

F Fais, F Ghiotto, S Hashimoto, B Sellars, A Valetto, S L Allen, P Schulman, V P Vinciguerra, K Rai, L Z Rassenti, T J Kipps, G Dighiero, H W Schroeder Jr, M Ferrarini, N Chiorazzi

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1981 Total
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Citations to this article in year 2007 (36)

Title and authors Publication Year
Immunoglobulin Diversity Gene Usage Predicts Unfavorable Outcome in a Subset of Unmutated Chronic Lymphocytic Leukemia
Renee C. Tschumper, Susan M. Geyer, Megan E. Campbell, Neil E. Kay, Tait D. Shanafelt, Clive S. Zent, Grzegorz S. Nowakowski, Timothy G. Call, Gordon W. Dewald, and Diane F. Jelinek
Journal of Clinical Investigation 2007
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia
V Fulci, S Chiaretti, M Goldoni, G Azzalin, N Carucci, S Tavolaro, L Castellano, A Magrelli, F Citarella, M Messina, R Maggio, N Peragine, S Santangelo, FR Mauro, P Landgraf, T Tuschl, DB Weir, M Chien, JJ Russo, J Ju, R Sheridan, C Sander, M Zavolan, A Guarini, R Foà, G Macino
Blood 2007
Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells
LD Vallat, Y Park, C Li, JG Gribben
Blood 2007
Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia
T Motiwala, S Majumder, H Kutay, DS Smith, DS Neuberg, DM Lucas, JC Byrd, M Grever, ST Jacob
Clinical cancer research 2007
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
F Murray, N Darzentas, A Hadzidimitriou, G Tobin, M Boudjogra, C Scielzo, N Laoutaris, K Karlsson, F Baran-Marzsak, A Tsaftaris, C Moreno, A Anagnostopoulos, F Caligaris-Cappio, D Vaur, C Ouzounis, C Belessi, P Ghia, F Davi, R Rosenquist, K Stamatopoulos
Blood 2007
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RN Damle, S Temburni, C Calissano, S Yancopoulos, T Banapour, C Sison, SL Allen, KR Rai, N Chiorazzi
Blood 2007
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International Journal of Laboratory Hematology 2007
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ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia
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Leukemia 2007
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L Muñoz, A Lasa, MT Carricondo, C Hernández, J Ubeda, JF Nomdedéu
Cytometry Part B: Clinical Cytometry 2007
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PC Everett, JA Meyers, A Makkinje, M Rabbi, A Lerner
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Z Balogh, L Reiniger, L Deák, C Bödör, J Csomor, Á Szepesi, É Gagyi, L Kopper, A Matolcsy
Hematological Oncology 2007
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L Terrin, L Trentin, M Degan, I Corradini, R Bertorelle, P Carli, N Maschio, MD Bo, F Noventa, V Gattei, G Semenzato, AD Rossi
Leukemia 2007
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MA Kharfan-Dabaja, C Anasetti, ES Santos
Biology of Blood and Marrow Transplantation 2007
CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia
P Josefsson, CH Geisler, H Leffers, JH Petersen, MK Andersen, J Jurlander, AM Buhl
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JB Weinberg, AD Volkheimer, Y Chen, BE Beasley, N Jiang, MC Lanasa, D Friedman, G Vaccaro, CW Rehder, CM DeCastro, DA Rizzieri, LF Diehl, JP Gockerman, JO Moore, BK Goodman, MC Levesque
American Journal of Hematology 2007
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TJ Kipps
Best Practice & Research Clinical Haematology 2007
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MH Farsangi, M Jeddi-Tehrani, RA Sharifian, SM Razavi, J Khoshnoodi, H Rabbani, F Shokri
Leukemia & Lymphoma 2007
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Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
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