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Citations to this article

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
Biva M. Desai, … , Steven D. Leach, Doris A. Stoffers
Biva M. Desai, … , Steven D. Leach, Doris A. Stoffers
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):971-977. https://doi.org/10.1172/JCI29988.
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Research Article Article has an altmetric score of 1

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration

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Abstract

It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing β cell mass in patients with diabetes. We report what we believe to be the first in vivo lineage tracing approach to determine the plasticity potential of pancreatic acinar cells. We developed an acinar cell–specific inducible Cre recombinase transgenic mouse, which, when mated with a reporter strain and pulsed with tamoxifen, resulted in permanent and specific labeling of acinar cells and their progeny. During various time periods of observation and using several models to provoke injury, we failed to observe any chase of the labeled cells into the endocrine compartment, indicating that acinar cells do not normally transdifferentiate into islet β cells in vivo in adult mice. In contrast, we observed a substantial role for replication of preexisting acinar cells in the regeneration of new acinar cells after partial pancreatectomy. These results indicate that mature acinar cells harbor a facultative acinar but not endocrine progenitor capacity.

Authors

Biva M. Desai, Jennifer Oliver-Krasinski, Diva D. De Leon, Cyrus Farzad, Nankang Hong, Steven D. Leach, Doris A. Stoffers

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 3 6 7 4 11 13 7 6 5 15 10 12 12 11 17 12 8 4 4 167
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2023 (7)

Title and authors Publication Year
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas
Zhao H, Huang X, Liu Z, Lai L, Sun R, Shen R, Li Y, He L, Pu W, Lv Z, Li Y, Han X, Liu X, Zhou B
Cell Discovery 2023
Wnt Pathway in Pancreatic Development and Pathophysiology
Napolitano T, Silvano S, Ayachi C, Plaisant M, Sousa-Da-Veiga A, Fofo H, Charles B, Collombat P
Cells 2023
Pancreatic Cancer: Advances and Challenges
Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A
Cell 2023
Perfect duet: Dual recombinases improve genetic resolution.
Li H, Weng W, Zhou B
Cell Proliferation 2023
The coordinated management of ribosome and translation during injury and regeneration
Nguyen T, Mills JC, Cho CJ
Frontiers in Cell and Developmental Biology 2023
Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia
Jiang J, Hakimjavadi H, Bray JK, Perkins C, Gosling A, daSilva L, Bulut G, Ali J, Setiawan VW, Campbell-Thompson M, Chamala S, Schmittgen TD
2023
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
Jiang Z, Wu F, Laise P, Takayuki T, Na F, Kim W, Kobayashi H, Chang W, Takahashi R, Valenti G, Sunagawa M, White RA, Macchini M, Renz BW, Middelhoff M, Hayakawa Y, Dubeykovskaya Z, Tan X, Chu T, Nagar K, Tailor Y, Belin BR, Anand A, Asfaha S, Finlayson MO, Iuga AC, Califano A, Wang TC
Cell Stem Cell 2023

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