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Usage Information

Synoviocyte-packaged Chlamydia trachomatis induces a chronic aseptic arthritis.
R D Inman, B Chiu
R D Inman, B Chiu
Published November 15, 1998
Citation Information: J Clin Invest. 1998;102(10):1776-1782. https://doi.org/10.1172/JCI2983.
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Research Article

Synoviocyte-packaged Chlamydia trachomatis induces a chronic aseptic arthritis.

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Abstract

The basic mechanisms underlying reactive arthritis and specifically the joint injury that follows intra-articular Chlamydia trachomatis infection have not been defined. The present study addresses this question through the development of an experimental model. Stable cell lines were generated from synoviocytes harvested from the knee joints of Lewis rats. The synoviocytes were cocultivated with C. trachomatis to allow invasion by the microbe and were then transferred by intra-articular injection into the knee joints of Lewis rats. The ensuing arthritis could be subdivided into an early phase (

Authors

R D Inman, B Chiu

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