The basic mechanisms underlying reactive arthritis and specifically the joint injury that follows intra-articular Chlamydia trachomatis infection have not been defined. The present study addresses this question through the development of an experimental model. Stable cell lines were generated from synoviocytes harvested from the knee joints of Lewis rats. The synoviocytes were cocultivated with C. trachomatis to allow invasion by the microbe and were then transferred by intra-articular injection into the knee joints of Lewis rats. The ensuing arthritis could be subdivided into an early phase (
R D Inman, B Chiu
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Chlamydia pecorum –Induced Arthritis in Experimentally and Naturally Infected Sheep
N Ostfeld, MM Islam, M Jelocnik, M Hilbe, T Sydler, S Hartnack, C Jacobson, T Clune, I Marsh, N Sales, A Polkinghorne, N Borel |
Veterinary pathology | 2020 |
The Importance of HLA-B27 in the Evolution of Reactive Arthritis
S Bănicioiu-Covei, A F Vreju, A Rosu, P L Ciurea |
Current Health Sciences Journal | 2019 |
Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections
CA Quintero, JG Tudela, MT Damiani |
Small GTPases | 2015 |
The role of intracellular organisms in the pathogenesis of inflammatory arthritis
A Singh, S Karrar |
International Journal of Inflammation | 2014 |
Nafamostat mesylate, a serine protease inhibitor, demonstrates novel antimicrobial properties and effectiveness in Chlamydia-induced arthritis
RD Inman, B Chiu |
Arthritis Research & Therapy | 2012 |
Sexually Transmitted Infections and Sexually Transmitted Diseases
GE Gross, SK Tyring |
2011 | |
Is the role of Chlamydia trachomatis underestimated in patients with suspected reactive arthritis?
MB OWLIA, AR ELEY |
International Journal of Rheumatic Diseases | 2010 |
Bone Marrow-derived Human Hematopoietic Stem Cells Engraft NOD/SCID Mice and Traffic Appropriately to an Inflammatory Stimulus in the Joint
NH Chang, RD Inman, JE Dick, JE Wither |
The Journal of rheumatology | 2010 |
Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis
RD Inman, B Chiu |
Arthritis Research & Therapy | 2009 |
Molecular Mechanisms of Spondyloarthropathies
C López-Larrea, R Díaz-Peña |
2009 | |
Early cytokine profiles in the joint define pathogen clearance and severity of arthritis inChlamydia-induced arthritis in rats
RD Inman, B Chiu |
Arthritis & Rheumatism | 2006 |
Innate immunity and arthritis: neutrophil rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis
Xiang Zhang, Michael Glogauer, Fei Zhu, Tae-Hwan Kim, Basil Chiu, Robert D. Inman |
Arthritis & Rheumatism | 2005 |
Synovial Fibroblasts Infected with Salmonella enterica Serovar Typhimurium Mediate Osteoclast Differentiation and Activation
X Zhang, JE Aubin, TH Kim, U Payne, B Chiu, RD Inman |
Infection and immunity | 2004 |
Reactive Arthritis
SG Childs |
Orthopaedic Nursing | 2004 |
Infection and Autoimmunity
C Dugué, Y Renaudineau, P Youinou |
Infection and Autoimmunity | 2004 |
Reactive arthritis or chronic infectious arthritis?
J Sibilia, FX Limbach |
Annals of the rheumatic diseases | 2002 |
Chlamydial conjunctivitis (in adults), uveitis, and reactive arthritis, including SARA
EM Haller-Schober, Y El-Shabrawi |
Best Practice & Research Clinical Obstetrics & Gynaecology | 2002 |
Breakdown of CTL tolerance to self HLA-B*2705 induced by exposure to Chlamydia trachomatis
I Popov, CS Cruz, BH Barber, B Chiu, RD Inman |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Role of Interferon-Stimulated Gene Factor 3γ and Beta Interferon in HLA Class I Enhancement in Synovial Fibroblasts upon Infection with Chlamydia trachomatis
J Rödel, H Vogelsang, K Prager, M Hartmann, KH Schmidt, E Straube |
Infection and immunity | 2002 |
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S Hess, C Rheinheimer, F Tidow, G Bartling, C Kaps, J Lauber, J Buer, A Klos |
Arthritis & Rheumatism | 2001 |
The Effect of an Anti-HLA-B27 Immune Response on CTL Recognition of Chlamydia
I Popov, CS Cruz, BH Barber, B Chiu, RD Inman |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Animal models of the spondyloarthropathies
M Breban, G Falgarone, H Blanchard, E Dernis-Labous, D Lamarque |
Current Rheumatology Reports | 2000 |
Chlamydia and associated arthritis:
RD Inman, JA Whittum-Hudson, HR Schumacher, AP Hudson |
Current Opinion in Rheumatology | 2000 |
Persistence of Chlamydia trachomatis Is Induced by Ciprofloxacin and Ofloxacin In Vitro
U Dreses-Werringloer, I Padubrin, B Jürgens-Saathoff, AP Hudson, H Zeidler, L Köhler |
Antimicrobial agents and chemotherapy | 2000 |
Reactive arthritis:
J Sieper, J Braun |
Current Opinion in Rheumatology | 1999 |
Reactive Arthritis. Reaktive Arthritis
J Braun, J Sieper |
LaboratoriumsMedizin | 1999 |
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes |
Postgraduate medical journal | 1991 |