Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
Stephanie Humblet-Baron, … , Daniel J. Campbell, David J. Rawlings
Stephanie Humblet-Baron, … , Daniel J. Campbell, David J. Rawlings
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):407-418. https://doi.org/10.1172/JCI29539.
View: Text | PDF
Research Article Immunology Article has an altmetric score of 3

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

  • Text
  • PDF
Abstract

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated whether alterations in Treg function might explain these paradoxical observations. While WASp-deficient (WASp–/–) mice exhibited normal thymic Treg generation, the competitive fitness of peripheral Tregs was severely compromised. The total percentage of forkhead box P3–positive (Foxp3+) Tregs among CD4+ T cells was reduced, and WASp–/– Tregs were rapidly outcompeted by WASp+ Tregs in vivo. These findings correlated with reduced expression of markers associated with self-antigen–driven peripheral Treg activation and homing to inflamed tissue. Consistent with these findings, WASp–/– Tregs showed a reduced ability to control aberrant T cell activation and autoimmune pathology in Foxp3–/–Scurfy (sf) mice. Finally, WASp+ Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spontaneous revertant mutation, indicating that altered Treg fitness likely explains the autoimmune features in human WAS.

Authors

Stephanie Humblet-Baron, Blythe Sather, Stephanie Anover, Shirly Becker-Herman, Debora J. Kasprowicz, Socheath Khim, Thuc Nguyen, Kelly Hudkins-Loya, Charles E. Alpers, Steve F. Ziegler, Hans Ochs, Troy Torgerson, Daniel J. Campbell, David J. Rawlings

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 2 3 4 4 2 6 5 3 10 6 6 7 6 7 8 6 3 88
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (88)

Title and authors Publication Year
Treg in inborn errors of immunity: gaps, knowns and future perspectives
Kennedy-Batalla R, Acevedo D, Luo Y, Esteve-Solé A, Vlagea A, Correa-Rocha R, Seoane-Reula ME, Alsina L
Frontiers in immunology 2024
DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans
Azizoglu ZB, Babayeva R, Haskologlu ZS, Acar MB, Ayaz-Guner S, Okus FZ, Alsavaf MB, Can S, Basaran KE, Canatan MF, Ozcan A, Erkmen H, Leblebici CB, Yilmaz E, Karakukcu M, Kose M, Canoz O, Özen A, Karakoc-Aydiner E, Ceylaner S, Gümüş G, Per H, Gumus H, Canatan H, Ozcan S, Dogu F, Ikinciogullari A, Unal E, Baris S, Eken A
Journal of Clinical Immunology 2024
Dendritic cells in inborn errors of immunity
Gupta S, Agrawal A
Frontiers in immunology 2023
Nature and nurture: understanding phenotypic variation in inborn errors of immunity
Similuk M, Kuijpers T
Frontiers in Cellular and Infection Microbiology 2023
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome.
Labrosse R, Chu JI, Armant MA, Everett JK, Pellin D, Kareddy N, Frelinger AL, Henderson LA, O'Connell AE, Biswas A, Coenen-van der Spek J, Miggelbrink A, Fiorini C, Adhikari H, Berry CC, Cantu VA, Fong J, Jaroslavsky J, Karadeniz DF, Li QZ, Reddy S, Roche AM, Zhu C, Whangbo JS, Dansereau C, Mackinnon B, Morris E, Koo SM, London WB, Baris S, Ozen A, Karakoc-Aydiner E, Despotovic JM, Forbes Satter LR, Saitoh A, Aizawa Y, King A, Nguyen MAT, Vu VDU, Snapper SB, Galy A, Notarangelo LD, Bushman FD, Williams DA, Pai SY
Blood 2023
IL-17-Dependent Dysregulated Cutaneous Immune Homeostasis in the Absence of the Wiskott–Aldrich Syndrome Protein
K Herman, T Yoshida, A Hughson, A Grier, S Gill, L Beck, D Fowell
Frontiers in immunology 2022
Inborn Errors of the Immune System Associated With Atopy
Nelson RW, Geha RS, McDonald DR
Frontiers in immunology 2022
Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Ishihara S, Sato T, Fujikado N, Miyazaki H, Yoshimoto T, Yamamoto H, Fukuda S, Katagiri K
2022
Diagnostic Challenges in Patients with Inborn Errors of Immunity with Different Manifestations of Immune Dysregulation.
Pieniawska-Śmiech K, Pasternak G, Lewandowicz-Uszyńska A, Jutel M
Journal of Clinical Medicine 2022
Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
L Dupré, K Boztug, L Pfajfer
Frontiers in Cell and Developmental Biology 2021
Hematopoietic Stem Cell Therapy for Wiskott–Aldrich Syndrome: Improved Outcome and Quality of Life
KK Mallhi, A Petrovic, HD Ochs
Journal of blood medicine 2021
Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering
L Raes, M Pille, A Harizaj, G Goetgeluk, JV Hoeck, S Stremersch, JC Fraire, T Brans, OG de Jong, R Maas-Bakker, E Mastrobattista, P Vader, SC Smedt, B Vandekerckhove, K Raemdonck, K Braeckmans
Molecular Therapy — Nucleic Acids 2021
Reversion Mosaicism in Primary Immunodeficiency Diseases
H Miyazawa, T Wada
Frontiers in immunology 2021
Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse
J Mastio, MB Saeed, H Wurzer, M Krecke, LS Westerberg, C Thomas
Frontiers in immunology 2020
Frequency and Manifestations of Autoimmunity Among Children Registered in the Kuwait National Primary Immunodeficiency Registry
MJ Massaad, M Zainal, W Al-Herz
Frontiers in immunology 2020
Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation
L Sereni, MC Castiello, F Marangoni, A Anselmo, D Silvestre, S Motta, E Draghici, S Mantero, AJ Thrasher, S Giliani, A Aiuti, P Mauri, LD Notarangelo, M Bosticardo, A Villa
Journal of Allergy and Clinical Immunology 2018
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
A Biswas, DS Shouval, A Griffith, JA Goettel, M Field, YH Kang, L Konnikova, E Janssen, NS Redhu, AJ Thrasher, T Chatila, VK Kuchroo, RS Geha, LD Notarangelo, SY Pai, BH Horwitz, SB Snapper
Nature Communications 2018
Primary atopic disorders
JJ Lyons, JD Milner
Journal of Experimental Medicine 2018
Patients with CD3G mutations reveal a role for human CD3γ in T reg diversity and suppressive function
JH Rowe, OM Delmonte, S Keles, BD Stadinski, AK Dobbs, LA Henderson, Y Yamazaki, LM Allende, FA Bonilla, LI Gonzalez-Granado, SC Celik, SN Guner, H Kapakli, C Yee, SY Pai, ES Huseby, I Reisli, JR Regueiro, LD Notarangelo
Blood 2018
Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome
KE Cervantes-Luevano, N Caronni, MC Castiello, E Fontana, GM Piperno, A Naseem, P Uva, M Bosticardo, GE Marcovecchio, LD Notarangelo, MP Cicalese, A Aiuti, A Villa, F Benvenuti
Journal of Allergy and Clinical Immunology 2018
TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease
JD Milner
Frontiers in immunology 2018
Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
S Singh, I Khan, S Khim, B Seymour, K Sommer, M Wielgosz, Z Norgaard, HP Kiem, J Adair, D Liggitt, A Nienhuis, DJ Rawlings
Molecular Therapy - Methods & Clinical Development 2017
In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott–Aldrich Syndrome Protein-Deficient B Cells
MC Castiello, F Pala, L Sereni, E Draghici, D Inverso, AV Sauer, F Schena, E Fontana, E Radaelli, P Uva, KE Cervantes-Luevano, F Benvenuti, PL Poliani, M Iannacone, E Traggiai, A Villa, M Bosticardo
Frontiers in immunology 2017
Wiskott-Aldrich syndrome protein: Emerging mechanisms in immunity
E Rivers, AJ Thrasher
European Journal of Immunology 2017
Low-dose interleukin-2 as a modulator of Treg homeostasis after HSCT: current understanding and future perspectives
K Matsuoka
International Journal of Hematology 2017
Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene
T Ohya, M Yanagimachi, K Iwasawa, S Umetsu, T Sogo, A Inui, T Fujisawa, S Ito
World journal of gastroenterology : WJG 2017
WASP, Tregs, and food allergies – rare disease provides insight into a common problem
Yun Liang, Johann Gudjonsson
Journal of Clinical Investigation 2016
Foxp3+ Tregs require WASP to restrain Th2-mediated food allergy
Willem Lexmond, Jeremy Goettel, Jonathan Lyons, Justin Jacobse, Marion Deken, Monica Lawrence, Thomas DiMaggio, daniel kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste Nelson, Nina Jones, Kelly Stone, Fabio Candotti, Edmond Rings, Adrian Thrasher, Joshua D. Milner, Scott Snapper, Edda Fiebiger
Journal of Clinical Investigation 2016
Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
MA Baptista, M Keszei, M Oliveira, KK Sunahara, J Andersson, CI Dahlberg, AJ Worth, A Liedén, IC Kuo, RP Wallin, SB Snapper, L Eidsmo, A Scheynius, MC Karlsson, G Bouma, SO Burns, MN Forsell, AJ Thrasher, S Nylén, LS Westerberg
Nature Communications 2016
Lentiviral-mediated gene therapy restores B-cell tolerance in Wiskott-Aldrich syndrome patients
Francesca Pala, Henner Morbach, Maria Carmina Castiello, Jean-Nicolas Schickel, Samantha Scaramuzza, Nicolas Chamberlain, Barbara Cassani, Salome Glauzy, Neil Romberg, Fabio Candotti, Alessandro Aiuti, Marita Bosticardo, Anna Villa, Eric Meffre
Journal of Clinical Investigation 2015
Harnessing Regulatory T Cells for the Treatment of Inflammatory Bowel Disease:
D Geem, A Harusato, K Flannigan, TL Denning
Inflammatory Bowel Diseases 2015
Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott–Aldrich Syndrome
V Cotta-de-Almeida, Là Dupré, D Guipouy, Z Vasconcelos
Frontiers in immunology 2015
A Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell Differentiation
OF Sarmento, PA Svingen, Y Xiong, RJ Xavier, D McGovern, TC Smyrk, KA Papadakis, RA Urrutia, WA Faubion
CMGH Cellular and Molecular Gastroenterology and Hepatology 2015
Atopic Dermatitis in Children
JJ Lyons, JD Milner, KD Stone
Immunology and Allergy Clinics of North America 2015
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion
XP Yang, K Jiang, K Hirahara, G Vahedi, B Afzali, G Sciume, M Bonelli, HW Sun, D Jankovic, Y Kanno, V Sartorelli, JJ O’Shea, A Laurence
Scientific Reports 2015
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
CI Dahlberg, ML Torres, SH Petersen, MA Baptista, M Keszei, S Volpi, EK Grasset, MC Karlsson, JE Walter, SB Snapper, LD Notarangelo, LS Westerberg
Journal of Autoimmunity 2015
Human Immunodeficiencies Related to Defective APC/T Cell Interaction
M Kallikourdis, A Viola, F Benvenuti
Frontiers in immunology 2015
Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice
T Yokoyama, A Yoshizaki, KL Simon, MR Kirby, SM Anderson, F Candotti, P Bobé
PloS one 2015
N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome
S Volpi, E Santori, K Abernethy, M Mizui, CI Dahlberg, M Recher, K Capuder, E Csizmadia, D Ryan, D Mathew, GC Tsokos, S Snapper, LS Westerberg, AJ Thrasher, F Candotti, LD Notarangelo
Blood 2015
Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells
G Bouma, NA Carter, M Recher, D Malinova, M Adriani, LD Notarangelo, SO Burns, C Mauri, AJ Thrasher
European Journal of Immunology 2014
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
BC Melnik, SM John, G Schmitz
Journal of Translational Medicine 2014
Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein
M Bosticardo, S Musio, E Fontana, S Angiari, E Draghici, G Constantin, PL Poliani, R Pedotti, A Villa
PloS one 2014
Thinking Out of the Box—New Approaches to Controlling GVHD
F Baron, S Humblet-Baron, G Ehx, S Servais, M Hannon, L Belle, C Lechanteur, A Briquet, O Giet, E Baudoux, E Willems, Y Beguin
Current Hematologic Malignancy Reports 2014
Wiskott-Aldrich syndrome: diagnosis, current management, and emerging treatments
D Buchbinder, DJ Nugent, AH Fillipovich
The Application of Clinical Genetics 2014
Nuclear Role of WASp in Gene Transcription Is Uncoupled from Its ARP2/3-Dependent Cytoplasmic Role in Actin Polymerization
S Sadhukhan, K Sarkar, M Taylor, F Candotti, YM Vyas
Journal of immunology (Baltimore, Md. : 1950) 2014
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Y Chen, J Aardema, S Kale, ZL Whichard, A Awomolo, E Blanchard, B Chang, DR Myers, L Ju, R Tran, D Reece, H Christensen, S Boukour, N Debili, TS Strom, D Rawlings, FX Vázquez, GA Voth, C Zhu, WH Kahr, WA Lam, SJ Corey
Blood 2013
Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells
F Prete, M Catucci, M Labrada, S Gobessi, MC Castiello, E Bonomi, A Aiuti, W Vermi, C Cancrini, A Metin, S Hambleton, R Bredius, LD Notarangelo, M der Burg, U Kalinke, A Villa, F Benvenuti
Journal of Experimental Medicine 2013
Colitis and Colon Cancer in WASP-Deficient Mice Require Helicobacter Species:
DD Nguyen, S Muthupalani, JA Goettel, MA Eston, M Mobley, NS Taylor, A McCabe, R Marin, SB Snapper, JG Fox
Inflammatory Bowel Diseases 2013
Actin cytoskeletal defects in immunodeficiency
DA Moulding, J Record, D Malinova, AJ Thrasher
Immunological Reviews 2013
Allogeneic Bone Marrow Transplantation Appears to Ameliorate IgA Nephropathy in a Patient with X-linked Thrombocytopenia
A Hoshino, M Shimizu, H Matsukura, H Sakaki-Nakatsubo, K Nomura, T Miyawaki, H Kanegane
Journal of Clinical Immunology 2013
Wiskott-Aldrich Syndrome Protein (WASp) Controls the Delivery of Platelet Transforming Growth Factor- 1
H Kim, H Falet, KM Hoffmeister, JH Hartwig
The Journal of biological chemistry 2013
B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
M Recher, SO Burns, MA de la Fuente, S Volpi, C Dahlberg, JE Walter, K Moffitt, D Mathew, N Honke, PA Lang, L Patrizi, H Falet, M Keszei, M Mizui, E Csizmadia, F Candotti, K Nadeau, G Bouma, OM Delmonte, F Frugoni, AB Fomin, D Buchbinder, EM Lundequist, MJ Massaad, GC Tsokos, J Hartwig, J Manis, C Terhorst, RS Geha, S Snapper, KS Lang, R Malley, L Westerberg, AJ Thrasher, LD Notarangelo
Blood 2012
Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp
R Sato, S Iiizumi, ES Kim, F Honda, SK Lee, N Adachi, H Koyama, S Mizutani, T Morio
International Journal of Hematology 2012
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome
A Astrakhan, BD Sather, BY Ryu, S Khim, S Singh, S Humblet-Baron, HD Ochs, CH Miao, DJ Rawlings
Blood 2012
Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma
M Catucci, MC Castiello, F Pala, M Bosticardo, A Villa
Frontiers in immunology 2012
Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1
F Lafouresse, V Cotta-de-Almeida, G Malet-Engra, A Galy, S Valitutti, L Dupré
Immunology 2012
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
PA Lang, N Shaabani, S Borkens, N Honke, S Scheu, S Booth, D Brenner, A Meryk, C Barthuber, M Recher, TW Mak, PS Ohashi, D Häussinger, GM Griffiths, AJ Thrasher, G Bouma, KS Lang
Journal of Allergy and Clinical Immunology 2012
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
DD Nguyen, MA Wurbel, JA Goettel, MA Eston, OS Ahmed, R Marin, EK Boden, EJ Villablanca, H Paidassi, V Ahuja, HC Reinecker, E Fiebiger, A Lacy-Hulbert, BH Horwitz, JR Mora, SB Snapper
Gastroenterology 2012
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
S Ramasamy, DD Nguyen, MA Eston, SN Alam, AK Moss, F Ebrahimi, B Biswas, G Mostafa, KT Chen, K Kaliannan, H Yammine, S Narisawa, JL Millán, HS Warren, EL Hohmann, E Mizoguchi, HC Reinecker, AK Bhan, SB Snapper, MS Malo, RA Hodin
Inflammatory Bowel Diseases 2011
Itk: The Rheostat of the T Cell Response
JA Grasis, CD Tsoukas
Journal of Signal Transduction 2011
Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases
SY Cleland, RM Siegel
FEBS Letters 2011
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
S Becker-Herman, A Meyer-Bahlburg, MA Schwartz, SW Jackson, KL Hudkins, C Liu, BD Sather, S Khim, D Liggitt, W Song, GJ Silverman, CE Alpers, DJ Rawlings
Journal of Experimental Medicine 2011
Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells
M Adriani, KA Jones, T Uchiyama, MR Kirby, C Silvin, SM Anderson, F Candotti
Blood 2011
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome
M Catucci, F Prete, M Bosticardo, MC Castiello, E Draghici, M Locci, MG Roncarolo, A Aiuti, F Benvenuti, A Villa
Gene Therapy 2011
WASP: a key immunological multitasker
AJ Thrasher, SO Burns
Nature Reviews Immunology 2010
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein
NP Nikolov, M Shimizu, S Cleland, D Bailey, J Aoki, T Strom, PL Schwartzberg, F Candotti, RM Siegel
Blood 2010
Stem-cell gene therapy for the Wiskott-Aldrich syndrome
K Boztug, M Schmidt, A Schwarzer, PP Banerjee, IA Díez, RA Dewey, M Böhm, A Nowrouzi, CR Ball, H Glimm, S Naundorf, K Kühlcke, R Blasczyk, I Kondratenko, L Maródi, JS Orange, C Kalle, C Klein
The New England journal of medicine 2010
Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome
MD Taylor, S Sadhukhan, P Kottangada, A Ramgopal, K Sarkar, S D'Silva, A Selvakumar, F Candotti, YM Vyas
Science Translational Medicine 2010
Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: advances in biology and future directions for treatment
SY Pai, LD Notarangelo
Immunology and Allergy Clinics of North America 2010
Clinical Aspects and Genetic Analysis of Taiwanese Patients with Wiskott–Aldrich Syndrome Protein Mutation: The First Identification of X-Linked Thrombocytopenia in the Chinese with Novel Mutations
WI Lee, JL Huang, TH Jaing, KH Wu, YH Chien, KW Chang
Journal of Clinical Immunology 2010
Immune pathology associated with altered actin cytoskeleton regulation
DC Wickramarachchi, AN Theofilopoulos, DH Kono
Autoimmunity 2010
Revertant somatic mosaicism in the Wiskott–Aldrich syndrome
BR Davis, F Candotti
Immunologic Research 2009
Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells
A Astrakhan, HD Ochs, DJ Rawlings
Journal of immunology (Baltimore, Md. : 1950) 2009
TH17 cells and regulatory T cells in primary immunodeficiency diseases
HD Ochs, M Oukka, TR Torgerson
Journal of Allergy and Clinical Immunology 2009
Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders
R Goyal, AC Bulua, NP Nikolov, PL Schwartzberg, RM Siegel
Current Opinion in Rheumatology 2009
Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation
G Bouma, SO Burns, AJ Thrasher
Immunobiology 2009
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
V Morales-Tirado, DK Sojka, SD Katzman, CA Lazarski, FD Finkelman, JF Urban, DJ Fowell
Blood 2009
Phosphorylation of WASp is a key regulator of activity and stability in vivo
MP Blundell, G Bouma, J Metelo, A Worth, Y Calle, LA Cowell, LS Westerberg, DA Moulding, S Mirando, C Kinnon, GO Cory, GE Jones, SB Snapper, SO Burns, AJ Thrasher
Proceedings of the National Academy of Sciences 2009
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption
BM Marathe, A Prislovsky, A Astrakhan, DJ Rawlings, JY Wan, TS Strom
Experimental Hematology 2009
Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men
LS Westerberg, C Klein, SB Snapper
Current Opinion in Immunology 2008
The thrombocytopenia of WAS: a familial form of ITP?
TS Strom
Immunologic Research 2008
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
A Meyer-Bahlburg, S Becker-Herman, S Humblet-Baron, S Khim, M Weber, G Bouma, AJ Thrasher, FD Batista, DJ Rawlings
Blood 2008
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
LS Westerberg, MA de la Fuente, F Wermeling, HD Ochs, MC Karlsson, SB Snapper, LD Notarangelo
Blood 2008
Development of lentiviral gene therapy for Wiskott Aldrich syndrome
A Galy, MG Roncarolo, AJ Thrasher
Expert Opinion on Biological Therapy 2008
Mutations of the Wiskott–Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes
HD Ochs
Immunologic Research 2008
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
DD Nguyen, MH Maillard, V Cotta-de-Almeida, E Mizoguchi, C Klein, I Fuss, C Nagler, A Mizoguchi, AK Bhan, SB Snapper
Gastroenterology 2007
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome
M Adriani, J Aoki, R Horai, AM Thornton, A Konno, M Kirby, SM Anderson, RM Siegel, F Candotti, PL Schwartzberg
Clinical Immunology 2007
Cytokines: Important for implantation?
G Chaouat, S Dubanchet, N Ledée
Journal of Assisted Reproduction and Genetics 2007

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 3 patents
122 readers on Mendeley
See more details