Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated whether alterations in Treg function might explain these paradoxical observations. While WASp-deficient (WASp–/–) mice exhibited normal thymic Treg generation, the competitive fitness of peripheral Tregs was severely compromised. The total percentage of forkhead box P3–positive (Foxp3+) Tregs among CD4+ T cells was reduced, and WASp–/– Tregs were rapidly outcompeted by WASp+ Tregs in vivo. These findings correlated with reduced expression of markers associated with self-antigen–driven peripheral Treg activation and homing to inflamed tissue. Consistent with these findings, WASp–/– Tregs showed a reduced ability to control aberrant T cell activation and autoimmune pathology in Foxp3–/–Scurfy (sf) mice. Finally, WASp+ Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spontaneous revertant mutation, indicating that altered Treg fitness likely explains the autoimmune features in human WAS.
Stephanie Humblet-Baron, Blythe Sather, Stephanie Anover, Shirly Becker-Herman, Debora J. Kasprowicz, Socheath Khim, Thuc Nguyen, Kelly Hudkins-Loya, Charles E. Alpers, Steve F. Ziegler, Hans Ochs, Troy Torgerson, Daniel J. Campbell, David J. Rawlings
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Treg in inborn errors of immunity: gaps, knowns and future perspectives
Kennedy-Batalla R, Acevedo D, Luo Y, Esteve-Solé A, Vlagea A, Correa-Rocha R, Seoane-Reula ME, Alsina L |
Frontiers in immunology | 2024 |
DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans
Azizoglu ZB, Babayeva R, Haskologlu ZS, Acar MB, Ayaz-Guner S, Okus FZ, Alsavaf MB, Can S, Basaran KE, Canatan MF, Ozcan A, Erkmen H, Leblebici CB, Yilmaz E, Karakukcu M, Kose M, Canoz O, Özen A, Karakoc-Aydiner E, Ceylaner S, Gümüş G, Per H, Gumus H, Canatan H, Ozcan S, Dogu F, Ikinciogullari A, Unal E, Baris S, Eken A |
Journal of Clinical Immunology | 2024 |
Dendritic cells in inborn errors of immunity
Gupta S, Agrawal A |
Frontiers in immunology | 2023 |
Nature and nurture: understanding phenotypic variation in inborn errors of immunity
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Frontiers in Cellular and Infection Microbiology | 2023 |
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome.
Labrosse R, Chu JI, Armant MA, Everett JK, Pellin D, Kareddy N, Frelinger AL, Henderson LA, O'Connell AE, Biswas A, Coenen-van der Spek J, Miggelbrink A, Fiorini C, Adhikari H, Berry CC, Cantu VA, Fong J, Jaroslavsky J, Karadeniz DF, Li QZ, Reddy S, Roche AM, Zhu C, Whangbo JS, Dansereau C, Mackinnon B, Morris E, Koo SM, London WB, Baris S, Ozen A, Karakoc-Aydiner E, Despotovic JM, Forbes Satter LR, Saitoh A, Aizawa Y, King A, Nguyen MAT, Vu VDU, Snapper SB, Galy A, Notarangelo LD, Bushman FD, Williams DA, Pai SY |
Blood | 2023 |
IL-17-Dependent Dysregulated Cutaneous Immune Homeostasis in the Absence of the Wiskott–Aldrich Syndrome Protein
K Herman, T Yoshida, A Hughson, A Grier, S Gill, L Beck, D Fowell |
Frontiers in immunology | 2022 |
Inborn Errors of the Immune System Associated With Atopy
Nelson RW, Geha RS, McDonald DR |
Frontiers in immunology | 2022 |
Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.
Ishihara S, Sato T, Fujikado N, Miyazaki H, Yoshimoto T, Yamamoto H, Fukuda S, Katagiri K |
2022 | |
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Journal of Clinical Medicine | 2022 |
Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
L Dupré, K Boztug, L Pfajfer |
Frontiers in Cell and Developmental Biology | 2021 |
Hematopoietic Stem Cell Therapy for Wiskott–Aldrich Syndrome: Improved Outcome and Quality of Life
KK Mallhi, A Petrovic, HD Ochs |
Journal of blood medicine | 2021 |
Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering
L Raes, M Pille, A Harizaj, G Goetgeluk, JV Hoeck, S Stremersch, JC Fraire, T Brans, OG de Jong, R Maas-Bakker, E Mastrobattista, P Vader, SC Smedt, B Vandekerckhove, K Raemdonck, K Braeckmans |
Molecular Therapy — Nucleic Acids | 2021 |
Reversion Mosaicism in Primary Immunodeficiency Diseases
H Miyazawa, T Wada |
Frontiers in immunology | 2021 |
Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse
J Mastio, MB Saeed, H Wurzer, M Krecke, LS Westerberg, C Thomas |
Frontiers in immunology | 2020 |
Frequency and Manifestations of Autoimmunity Among Children Registered in the Kuwait National Primary Immunodeficiency Registry
MJ Massaad, M Zainal, W Al-Herz |
Frontiers in immunology | 2020 |
Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation
L Sereni, MC Castiello, F Marangoni, A Anselmo, D Silvestre, S Motta, E Draghici, S Mantero, AJ Thrasher, S Giliani, A Aiuti, P Mauri, LD Notarangelo, M Bosticardo, A Villa |
Journal of Allergy and Clinical Immunology | 2018 |
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
A Biswas, DS Shouval, A Griffith, JA Goettel, M Field, YH Kang, L Konnikova, E Janssen, NS Redhu, AJ Thrasher, T Chatila, VK Kuchroo, RS Geha, LD Notarangelo, SY Pai, BH Horwitz, SB Snapper |
Nature Communications | 2018 |
Primary atopic disorders
JJ Lyons, JD Milner |
Journal of Experimental Medicine | 2018 |
Patients with CD3G mutations reveal a role for human CD3γ in T reg diversity and suppressive function
JH Rowe, OM Delmonte, S Keles, BD Stadinski, AK Dobbs, LA Henderson, Y Yamazaki, LM Allende, FA Bonilla, LI Gonzalez-Granado, SC Celik, SN Guner, H Kapakli, C Yee, SY Pai, ES Huseby, I Reisli, JR Regueiro, LD Notarangelo |
Blood | 2018 |
Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome
KE Cervantes-Luevano, N Caronni, MC Castiello, E Fontana, GM Piperno, A Naseem, P Uva, M Bosticardo, GE Marcovecchio, LD Notarangelo, MP Cicalese, A Aiuti, A Villa, F Benvenuti |
Journal of Allergy and Clinical Immunology | 2018 |
TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease
JD Milner |
Frontiers in immunology | 2018 |
Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
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Molecular Therapy - Methods & Clinical Development | 2017 |
In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott–Aldrich Syndrome Protein-Deficient B Cells
MC Castiello, F Pala, L Sereni, E Draghici, D Inverso, AV Sauer, F Schena, E Fontana, E Radaelli, P Uva, KE Cervantes-Luevano, F Benvenuti, PL Poliani, M Iannacone, E Traggiai, A Villa, M Bosticardo |
Frontiers in immunology | 2017 |
Wiskott-Aldrich syndrome protein: Emerging mechanisms in immunity
E Rivers, AJ Thrasher |
European Journal of Immunology | 2017 |
Low-dose interleukin-2 as a modulator of Treg homeostasis after HSCT: current understanding and future perspectives
K Matsuoka |
International Journal of Hematology | 2017 |
Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene
T Ohya, M Yanagimachi, K Iwasawa, S Umetsu, T Sogo, A Inui, T Fujisawa, S Ito |
World journal of gastroenterology : WJG | 2017 |
WASP, Tregs, and food allergies – rare disease provides insight into a common problem
Yun Liang, Johann Gudjonsson |
Journal of Clinical Investigation | 2016 |
Foxp3+ Tregs require WASP to restrain Th2-mediated food allergy
Willem Lexmond, Jeremy Goettel, Jonathan Lyons, Justin Jacobse, Marion Deken, Monica Lawrence, Thomas DiMaggio, daniel kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste Nelson, Nina Jones, Kelly Stone, Fabio Candotti, Edmond Rings, Adrian Thrasher, Joshua D. Milner, Scott Snapper, Edda Fiebiger |
Journal of Clinical Investigation | 2016 |
Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
MA Baptista, M Keszei, M Oliveira, KK Sunahara, J Andersson, CI Dahlberg, AJ Worth, A Liedén, IC Kuo, RP Wallin, SB Snapper, L Eidsmo, A Scheynius, MC Karlsson, G Bouma, SO Burns, MN Forsell, AJ Thrasher, S Nylén, LS Westerberg |
Nature Communications | 2016 |
Lentiviral-mediated gene therapy restores B-cell tolerance in Wiskott-Aldrich syndrome patients
Francesca Pala, Henner Morbach, Maria Carmina Castiello, Jean-Nicolas Schickel, Samantha Scaramuzza, Nicolas Chamberlain, Barbara Cassani, Salome Glauzy, Neil Romberg, Fabio Candotti, Alessandro Aiuti, Marita Bosticardo, Anna Villa, Eric Meffre |
Journal of Clinical Investigation | 2015 |
Harnessing Regulatory T Cells for the Treatment of Inflammatory Bowel Disease:
D Geem, A Harusato, K Flannigan, TL Denning |
Inflammatory Bowel Diseases | 2015 |
Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott–Aldrich Syndrome
V Cotta-de-Almeida, Là Dupré, D Guipouy, Z Vasconcelos |
Frontiers in immunology | 2015 |
A Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell Differentiation
OF Sarmento, PA Svingen, Y Xiong, RJ Xavier, D McGovern, TC Smyrk, KA Papadakis, RA Urrutia, WA Faubion |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2015 |
Atopic Dermatitis in Children
JJ Lyons, JD Milner, KD Stone |
Immunology and Allergy Clinics of North America | 2015 |
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion
XP Yang, K Jiang, K Hirahara, G Vahedi, B Afzali, G Sciume, M Bonelli, HW Sun, D Jankovic, Y Kanno, V Sartorelli, JJ O’Shea, A Laurence |
Scientific Reports | 2015 |
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
CI Dahlberg, ML Torres, SH Petersen, MA Baptista, M Keszei, S Volpi, EK Grasset, MC Karlsson, JE Walter, SB Snapper, LD Notarangelo, LS Westerberg |
Journal of Autoimmunity | 2015 |
Human Immunodeficiencies Related to Defective APC/T Cell Interaction
M Kallikourdis, A Viola, F Benvenuti |
Frontiers in immunology | 2015 |
Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice
T Yokoyama, A Yoshizaki, KL Simon, MR Kirby, SM Anderson, F Candotti, P Bobé |
PloS one | 2015 |
N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome
S Volpi, E Santori, K Abernethy, M Mizui, CI Dahlberg, M Recher, K Capuder, E Csizmadia, D Ryan, D Mathew, GC Tsokos, S Snapper, LS Westerberg, AJ Thrasher, F Candotti, LD Notarangelo |
Blood | 2015 |
Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells
G Bouma, NA Carter, M Recher, D Malinova, M Adriani, LD Notarangelo, SO Burns, C Mauri, AJ Thrasher |
European Journal of Immunology | 2014 |
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
BC Melnik, SM John, G Schmitz |
Journal of Translational Medicine | 2014 |
Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein
M Bosticardo, S Musio, E Fontana, S Angiari, E Draghici, G Constantin, PL Poliani, R Pedotti, A Villa |
PloS one | 2014 |
Thinking Out of the Box—New Approaches to Controlling GVHD
F Baron, S Humblet-Baron, G Ehx, S Servais, M Hannon, L Belle, C Lechanteur, A Briquet, O Giet, E Baudoux, E Willems, Y Beguin |
Current Hematologic Malignancy Reports | 2014 |
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D Buchbinder, DJ Nugent, AH Fillipovich |
The Application of Clinical Genetics | 2014 |
Nuclear Role of WASp in Gene Transcription Is Uncoupled from Its ARP2/3-Dependent Cytoplasmic Role in Actin Polymerization
S Sadhukhan, K Sarkar, M Taylor, F Candotti, YM Vyas |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Y Chen, J Aardema, S Kale, ZL Whichard, A Awomolo, E Blanchard, B Chang, DR Myers, L Ju, R Tran, D Reece, H Christensen, S Boukour, N Debili, TS Strom, D Rawlings, FX Vázquez, GA Voth, C Zhu, WH Kahr, WA Lam, SJ Corey |
Blood | 2013 |
Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells
F Prete, M Catucci, M Labrada, S Gobessi, MC Castiello, E Bonomi, A Aiuti, W Vermi, C Cancrini, A Metin, S Hambleton, R Bredius, LD Notarangelo, M der Burg, U Kalinke, A Villa, F Benvenuti |
Journal of Experimental Medicine | 2013 |
Colitis and Colon Cancer in WASP-Deficient Mice Require Helicobacter Species:
DD Nguyen, S Muthupalani, JA Goettel, MA Eston, M Mobley, NS Taylor, A McCabe, R Marin, SB Snapper, JG Fox |
Inflammatory Bowel Diseases | 2013 |
Actin cytoskeletal defects in immunodeficiency
DA Moulding, J Record, D Malinova, AJ Thrasher |
Immunological Reviews | 2013 |
Allogeneic Bone Marrow Transplantation Appears to Ameliorate IgA Nephropathy in a Patient with X-linked Thrombocytopenia
A Hoshino, M Shimizu, H Matsukura, H Sakaki-Nakatsubo, K Nomura, T Miyawaki, H Kanegane |
Journal of Clinical Immunology | 2013 |
Wiskott-Aldrich Syndrome Protein (WASp) Controls the Delivery of Platelet Transforming Growth Factor- 1
H Kim, H Falet, KM Hoffmeister, JH Hartwig |
The Journal of biological chemistry | 2013 |
B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
M Recher, SO Burns, MA de la Fuente, S Volpi, C Dahlberg, JE Walter, K Moffitt, D Mathew, N Honke, PA Lang, L Patrizi, H Falet, M Keszei, M Mizui, E Csizmadia, F Candotti, K Nadeau, G Bouma, OM Delmonte, F Frugoni, AB Fomin, D Buchbinder, EM Lundequist, MJ Massaad, GC Tsokos, J Hartwig, J Manis, C Terhorst, RS Geha, S Snapper, KS Lang, R Malley, L Westerberg, AJ Thrasher, LD Notarangelo |
Blood | 2012 |
Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp
R Sato, S Iiizumi, ES Kim, F Honda, SK Lee, N Adachi, H Koyama, S Mizutani, T Morio |
International Journal of Hematology | 2012 |
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome
A Astrakhan, BD Sather, BY Ryu, S Khim, S Singh, S Humblet-Baron, HD Ochs, CH Miao, DJ Rawlings |
Blood | 2012 |
Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma
M Catucci, MC Castiello, F Pala, M Bosticardo, A Villa |
Frontiers in immunology | 2012 |
Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1
F Lafouresse, V Cotta-de-Almeida, G Malet-Engra, A Galy, S Valitutti, L Dupré |
Immunology | 2012 |
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
PA Lang, N Shaabani, S Borkens, N Honke, S Scheu, S Booth, D Brenner, A Meryk, C Barthuber, M Recher, TW Mak, PS Ohashi, D Häussinger, GM Griffiths, AJ Thrasher, G Bouma, KS Lang |
Journal of Allergy and Clinical Immunology | 2012 |
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice
DD Nguyen, MA Wurbel, JA Goettel, MA Eston, OS Ahmed, R Marin, EK Boden, EJ Villablanca, H Paidassi, V Ahuja, HC Reinecker, E Fiebiger, A Lacy-Hulbert, BH Horwitz, JR Mora, SB Snapper |
Gastroenterology | 2012 |
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
S Ramasamy, DD Nguyen, MA Eston, SN Alam, AK Moss, F Ebrahimi, B Biswas, G Mostafa, KT Chen, K Kaliannan, H Yammine, S Narisawa, JL Millán, HS Warren, EL Hohmann, E Mizoguchi, HC Reinecker, AK Bhan, SB Snapper, MS Malo, RA Hodin |
Inflammatory Bowel Diseases | 2011 |
Itk: The Rheostat of the T Cell Response
JA Grasis, CD Tsoukas |
Journal of Signal Transduction | 2011 |
Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases
SY Cleland, RM Siegel |
FEBS Letters | 2011 |
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
S Becker-Herman, A Meyer-Bahlburg, MA Schwartz, SW Jackson, KL Hudkins, C Liu, BD Sather, S Khim, D Liggitt, W Song, GJ Silverman, CE Alpers, DJ Rawlings |
Journal of Experimental Medicine | 2011 |
Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells
M Adriani, KA Jones, T Uchiyama, MR Kirby, C Silvin, SM Anderson, F Candotti |
Blood | 2011 |
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome
M Catucci, F Prete, M Bosticardo, MC Castiello, E Draghici, M Locci, MG Roncarolo, A Aiuti, F Benvenuti, A Villa |
Gene Therapy | 2011 |
WASP: a key immunological multitasker
AJ Thrasher, SO Burns |
Nature Reviews Immunology | 2010 |
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein
NP Nikolov, M Shimizu, S Cleland, D Bailey, J Aoki, T Strom, PL Schwartzberg, F Candotti, RM Siegel |
Blood | 2010 |
Stem-cell gene therapy for the Wiskott-Aldrich syndrome
K Boztug, M Schmidt, A Schwarzer, PP Banerjee, IA Díez, RA Dewey, M Böhm, A Nowrouzi, CR Ball, H Glimm, S Naundorf, K Kühlcke, R Blasczyk, I Kondratenko, L Maródi, JS Orange, C Kalle, C Klein |
The New England journal of medicine | 2010 |
Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome
MD Taylor, S Sadhukhan, P Kottangada, A Ramgopal, K Sarkar, S D'Silva, A Selvakumar, F Candotti, YM Vyas |
Science Translational Medicine | 2010 |
Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: advances in biology and future directions for treatment
SY Pai, LD Notarangelo |
Immunology and Allergy Clinics of North America | 2010 |
Clinical Aspects and Genetic Analysis of Taiwanese Patients with Wiskott–Aldrich Syndrome Protein Mutation: The First Identification of X-Linked Thrombocytopenia in the Chinese with Novel Mutations
WI Lee, JL Huang, TH Jaing, KH Wu, YH Chien, KW Chang |
Journal of Clinical Immunology | 2010 |
Immune pathology associated with altered actin cytoskeleton regulation
DC Wickramarachchi, AN Theofilopoulos, DH Kono |
Autoimmunity | 2010 |
Revertant somatic mosaicism in the Wiskott–Aldrich syndrome
BR Davis, F Candotti |
Immunologic Research | 2009 |
Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells
A Astrakhan, HD Ochs, DJ Rawlings |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
TH17 cells and regulatory T cells in primary immunodeficiency diseases
HD Ochs, M Oukka, TR Torgerson |
Journal of Allergy and Clinical Immunology | 2009 |
Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders
R Goyal, AC Bulua, NP Nikolov, PL Schwartzberg, RM Siegel |
Current Opinion in Rheumatology | 2009 |
Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation
G Bouma, SO Burns, AJ Thrasher |
Immunobiology | 2009 |
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
V Morales-Tirado, DK Sojka, SD Katzman, CA Lazarski, FD Finkelman, JF Urban, DJ Fowell |
Blood | 2009 |
Phosphorylation of WASp is a key regulator of activity and stability in vivo
MP Blundell, G Bouma, J Metelo, A Worth, Y Calle, LA Cowell, LS Westerberg, DA Moulding, S Mirando, C Kinnon, GO Cory, GE Jones, SB Snapper, SO Burns, AJ Thrasher |
Proceedings of the National Academy of Sciences | 2009 |
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption
BM Marathe, A Prislovsky, A Astrakhan, DJ Rawlings, JY Wan, TS Strom |
Experimental Hematology | 2009 |
Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men
LS Westerberg, C Klein, SB Snapper |
Current Opinion in Immunology | 2008 |
The thrombocytopenia of WAS: a familial form of ITP?
TS Strom |
Immunologic Research | 2008 |
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
A Meyer-Bahlburg, S Becker-Herman, S Humblet-Baron, S Khim, M Weber, G Bouma, AJ Thrasher, FD Batista, DJ Rawlings |
Blood | 2008 |
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
LS Westerberg, MA de la Fuente, F Wermeling, HD Ochs, MC Karlsson, SB Snapper, LD Notarangelo |
Blood | 2008 |
Development of lentiviral gene therapy for Wiskott Aldrich syndrome
A Galy, MG Roncarolo, AJ Thrasher |
Expert Opinion on Biological Therapy | 2008 |
Mutations of the Wiskott–Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes
HD Ochs |
Immunologic Research | 2008 |
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein
DD Nguyen, MH Maillard, V Cotta-de-Almeida, E Mizoguchi, C Klein, I Fuss, C Nagler, A Mizoguchi, AK Bhan, SB Snapper |
Gastroenterology | 2007 |
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome
M Adriani, J Aoki, R Horai, AM Thornton, A Konno, M Kirby, SM Anderson, RM Siegel, F Candotti, PL Schwartzberg |
Clinical Immunology | 2007 |
Cytokines: Important for implantation?
G Chaouat, S Dubanchet, N Ledée |
Journal of Assisted Reproduction and Genetics | 2007 |