JCI - Citations to Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

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Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

Karl S. Lang, … , Hans Hengartner, Rolf M. Zinkernagel

Karl S. Lang, … , Hans Hengartner, Rolf M. Zinkernagel

Published September 1, 2006
Citation Information: J Clin Invest. 2006;116(9):2456-2463. https://doi.org/10.1172/JCI28349.

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Research Article Autoimmunity

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Citations to this article (77)

Title and authors	Publication	Year
The role of recipient sex in the post-liver transplant prognosis of acute-on-chronic liver failure Lee DU, Shaik MR, Yerneni S, Harmacinski A, Shaik NA, Evey K, Bhowmick K, Mujahid Z, Cha Y, Chou H, Yi A, Lee K, Fan GH, Malik R	Journal of liver transplantation	2025
Intelligent Hydrogel-Assisted Hepatocellular Carcinoma Therapy Tang Z, Deng L, Zhang J, Jiang T, Xiang H, Chen Y, Liu H, Cai Z, Cui W, Xiong Y	Research	2024
Is machine learning-based assessment of tumor-infiltrating lymphocytes on standard histologic images associated with outcomes of immunotherapy in patients with NSCLC? Inamura K, Shigematsu Y	Journal of Thoracic Disease	2023
Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals Wang J, Liu Q, Zhou Y, Cao C, Chen P, Meng G, Zhang J, Xin X, Huang G, Wu Y	iScience	2023
Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis Rath CT, Vivarini ÁC, dos Santos JV, Medina JM, Saliba AM, Mottram JC, Lima AP, Calegari-Silva TC, Pereira RM, Lopes UG	Infection and immunity	2022
Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis Su Z, Chen J, Zhang J, An Y, Liao Y, Wu X, Tao C, Wang L, Cai B	Journal of Immunology Research	2022
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts Sonakshi Bhattacharjee, Florian Hamberger, Aashreya Ravichandra, Maximilian Miller, Silvia Affo, Ajay Nair, Aveline Filliol, LiKang Chin, Thomas Savage, Deqi Yin, Naita.M. Wirsik, Adam Mehal, Nicholas Arpaia, Ekihiro Seki, Matthias Mack, Di Zhu, Peter A. Sims, Ben Stanger, Kenneth P. Olive, Thomas Schmidt, Rebecca G. Wells, Ingmar Mederacke, Robert F Schwabe	Journal of Clinical Investigation	2021
Host Immune Responses after Suprachoroidal Delivery of AAV8 in Nonhuman Primate Eyes SH Chung, IN Mollhoff, A Mishra, TN Sin, T Ngo, T Ciulla, P Sieving, SM Thomasy, G Yiu	Human Gene Therapy	2021
The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy Y Kamal, SL Schmit, HR Frost, CI Amos	Immunotherapy	2020
Pattern Recognition Receptors: Significance of Expression in the Liver J Żeromski, A Kierepa, B Brzezicha, A Kowala-Piaskowska, I Mozer-Lisewska	Archivum Immunologiae et Therapiae Experimentalis	2020
TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy SN Ashley, S Somanathan, AR Giles, JM Wilson	Cellular Immunology	2019
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study R Chavez-Valdez, A Mottahedin, L Stridh, TR Yellowhair, LL Jantzie, FJ Northington, C Mallard	Frontiers in physiology	2019
Elevated serum levels of IL-6 and CXCL9 in autoimmune retinopathy (AIR) patients B Detrick, S Gangaputra, DN Palsgrove, CD Heaney, JJ Hooks, HN Sen	Journal of Neuroimmunology	2018
Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease: Lymphatic system-specific viral replication SK Friedrich, PA Lang, J Friebus-Kardash, V Duhan, J Bezgovsek, KS Lang	Clinical & Experimental Immunology	2018
Immunodivergence in Metastatic Colorectal Cancer CE de Andrea, KA Schalper, MF Sanmamed, I Melero	Cancer Cell	2018
Unraveling the complex story of immune responses to AAV vectors trial after trial C Vandamme, O ADJALI, F Mingozzi	Human Gene Therapy	2017
Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells N Honke, N Shaabani, JR Teijaro, U Christen, C Hardt, J Bezgovsek, PA Lang, KS Lang	Frontiers in immunology	2017
The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system: HFE and the immune response A Reuben, JW Chung, R Lapointe, MM Santos	Immunity, Inflammation and Disease	2017
Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance Z Zeng, L Li, Y Chen, H Wei, R Sun, Z Tian	Journal of Experimental Medicine	2016
Management of immunosuppressant agents following liver transplantation: Less is more MS Ascha	World journal of hepatology	2016
Antigen-driven focal inflammatory death of malaria liver stages G Bayarsaikhan, M Akbari, K Yui, R Amino	Frontiers in microbiology	2015
Innate Immune Signaling Induces IL-7 Production, Early Inflammatory Responses, and Sjögren's-Like Dacryoadenitis in C57BL/6 Mice J Zhou, JO Jin, J Du, Q Yu	Investigative ophthalmology & visual science	2015
Immunopathogenesis of chronic hepatitis B IP Balmasova	World journal of gastroenterology : WJG	2014
Hepatocyte growth factor in dampening liver immune-mediated pathology in acute viral hepatitis without compromising antiviral activity: Hepatocyte growth factor in hepatitis R Aguilar-Valenzuela, ED Carlsen, Y Liang, L Soong, J Sun	Journal of Gastroenterology and Hepatology	2014
Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3 CL Wilson, J Mann, M Walsh, MJ Perrugoria, F Oakley, MC Wright, C Brignole, DD Paolo, P Perri, M Ponzoni, M Karin, DA Mann	PloS one	2014
Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis M Yüksel, D Laukens, F Heindryckx, HV Vlierberghe, A Geerts, FS Wong, L Wen, I Colle	International Journal of Experimental Pathology	2014
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection P Liehl, V Zuzarte-Luís, J Chan, T Zillinger, F Baptista, D Carapau, M Konert, KK Hanson, C Carret, C Lassnig, M Müller, U Kalinke, M Saeed, AF Chora, DT Golenbock, B Strobl, M Prudêncio, LP Coelho, SH Kappe, G Superti-Furga, A Pichlmair, AM Vigário, CM Rice, KA Fitzgerald, W Barchet, MM Mota	Nature Medicine	2013
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection LR Huang, D Wohlleber, F Reisinger, CN Jenne, RL Cheng, Z Abdullah, FA Schildberg, M Odenthal, HP Dienes, N van Rooijen, E Schmitt, N Garbi, M Croft, C Kurts, P Kubes, U Protzer, M Heikenwalder, PA Knolle	Nature Immunology	2013
Transcriptional response of chicken embryo cells to Newcastle disease virus (D58 strain) infection R Kumar, JJ Kirubaharan, ND Chandran, N Gnanapriya	Indian Journal of Virology	2013
Association betweenTLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users K Huik, R Avi, M Pauskar, E Kallas, EL Jõgeda, T Karki, K Marsh, DD Jarlais, A Uusküla, I Lutsar	Infection, Genetics and Evolution	2013
Toll-like receptor 3 in viral pathogenesis: friend or foe? R Perales-Linares, S Navas-Martin	Immunology	2013
Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes N Honke, N Shaabani, DE Zhang, G Iliakis, HC Xu, D Häussinger, M Recher, M Löhning, PA Lang, KS Lang	PLoS pathogens	2013
Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking tyro3, axl and mer receptor tyrosine kinases N Qi, P Liu, Y Zhang, H Wu, Y Chen, D Han	PloS one	2013
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity KA Cavassani, AP Moreira, D Habiel, T Ito, AL Coelho, RM Allen, B Hu, J Raphelson, WF 4th, MA Schaller, NW Lukacs, MB Omary, CM Hogaboam, SL Kunkel	PloS one	2013
Type I interferon receptor deficiency prevents murine Sjogren's syndrome BM Szczerba, PD Rybakowska, P Dey, KM Payerhin, AB Peck, H Bagavant, US Deshmukh	Journal of dental research	2013
Immunization with a Recombinant Vaccinia Virus That Encodes Nonstructural Proteins of the Hepatitis C Virus Suppresses Viral Protein Levels in Mouse Liver S Sekiguchi, K Kimura, T Chiyo, T Ohtsuki, Y Tobita, Y Tokunaga, F Yasui, K Tsukiyama-Kohara, T Wakita, T Tanaka, M Miyasaka, K Mizuno, Y Hayashi, T Hishima, K Matsushima, M Kohara, NH Shoukry	PloS one	2012
Leishmania RNA virus: when the host pays the toll MA Hartley, C Ronet, H Zangger, SM Beverley, N Fasel	Frontiers in Cellular and Infection Microbiology	2012
Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients V Chew, C Tow, C Huang, E Bard-Chapeau, NG Copeland, NA Jenkins, A Weber, KH Lim, HC Toh, M Heikenwalder, IO Ng, A Nardin, JP Abastado	JNCI Journal of the National Cancer Institute	2012
Systemic administration of TLR3 agonist induces IL-7 expression and IL-7-dependent CXCR3 ligand production in the lung JO Jin, Q Yu	Journal of leukocyte biology	2012
RNA mediated toll-like receptor stimulation in health and disease AH Dalpke, M Helm	RNA biology	2012
Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice BJ Roberts, JA Dragon, M Moussawi, SA Huber	Biology of sex differences	2012
Liver restores immune homeostasis after local inflammation despite the presence of autoreactive T cells K Béland, P Lapierre, I Djilali-Saiah, F Alvarez	PloS one	2012
Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency M Mastri, Z Shah, T McLaughlin, CJ Greene, L Baum, G Suzuki, T Lee	American journal of physiology. Cell physiology	2012
Different Toll-Like Receptor Stimuli Have a Profound Impact on Cytokines Required to Break Tolerance and Induce Autoimmunity AC Lin, D Dissanayake, S Dhanji, AR Elford, PS Ohashi	PloS one	2011
Leishmania RNA Virus Controls the Severity of Mucocutaneous Leishmaniasis A Ives, C Ronet, F Prevel, G Ruzzante, S Fuertes-Marraco, F Schutz, H Zangger, M Revaz-Breton, LF Lye, SM Hickerson, SM Beverley, H Acha-Orbea, P Launois, N Fasel, S Masina	Science (New York, N.Y.)	2011
Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59 JL Aparicio, C Peña, LA Retegui	International Immunopharmacology	2011
Use of Toll-Like Receptor 3 Agonists Against Respiratory Viral Infections Christopher M, Wong J	Anti-inflammatory & anti-allergy agents in medicinal chemistry	2011
Cross-priming in health and disease C Kurts, BW Robinson, PA Knolle	Nature Reviews Immunology	2010
AAV Vectors Avoid Inflammatory Signals Necessary to Render Transduced Hepatocyte Targets for Destructive T Cells S Somanathan, E Breous, P Bell, JM Wilson	Molecular Therapy	2010
Toll-like receptor 3 in liver diseases S Yin, B Gao	Gastroenterology Research and Practice	2010
Liver Antigen-Presenting Cells IN Crispe	Journal of Hepatology	2010
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans HE Wasmuth, F Lammert, MM Zaldivar, R Weiskirchen, C Hellerbrand, D Scholten, ML Berres, H Zimmermann, KL Streetz, F Tacke, S Hillebrandt, P Schmitz, H Keppeler, T Berg, E Dahl, N Gassler, SL Friedman, C Trautwein	Gastroenterology	2009
Immunotherapy for liver tumors: present status and future prospects P Matar, L Alaniz, V Rozados, JB Aquino, M Malvicini, C Atorrasagasti, M Gidekel, M Silva, OG Scharovsky, G Mazzolini	Journal of Biomedical Science	2009
Influence of genes, sex, age and environment on the onset of autoimmune hepatitis K Béland, P Lapierre, F Alvarez	World journal of gastroenterology : WJG	2009
Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3 S Donnelly, SM O'Neill, CM Stack, MW Robinson, L Turnbull, C Whitchurch, JP Dalton	The Journal of biological chemistry	2009
The autoimmune response induced by mouse hepatitis virus A59 is expanded by a hepatotoxic agent JL Aparicio, M Duhalde-Vega, ME Loureiro, LA Retegui	International Immunopharmacology	2009
Liver architecture, cell function, and disease H Ishibashi, M Nakamura, A Komori, K Migita, S Shimoda	Seminars in Immunopathology	2009
Inflammatory regulation by TLR3 in acute hepatitis X Xiao, P Zhao, D Rodriguez-Pinto, D Qi, O Henegariu, L Alexopoulou, RA Flavell, FS Wong, L Wen	Journal of immunology (Baltimore, Md. : 1950)	2009
MyD88 Intrinsically Regulates CD4 T-Cell Responses S Zhou, EA Kurt-Jones, AM Cerny, M Chan, RT Bronson, RW Finberg	Journal of virology	2009
Hepatic Gene Transfer as a Means of Tolerance Induction to Transgene Products LoDuca PA, Hoffman BE, Herzog RW	Current gene therapy	2009
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events KA Cavassani, M Ishii, H Wen, MA Schaller, PM Lincoln, NW Lukacs, CM Hogaboam, SL Kunkel	Journal of Experimental Medicine	2008
Developmental and epigenetic regulation of the human TLR3 gene A Porrás, S Kozar, V Russanova, P Salpea, T Hirai, N Sammons, P Mittal, JY Kim, K Ozato, R Romero, BH Howard	Molecular Immunology	2008
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection A Das, M Hoare, N Davies, AR Lopes, C Dunn, PT Kennedy, G Alexander, H Finney, A Lawson, FJ Plunkett, A Bertoletti, AN Akbar, MK Maini	Journal of Experimental Medicine	2008
Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death LE Holz, V Benseler, DG Bowen, P Bouillet, A Strasser, L O'Reilly, WM d'Avigdor, AG Bishop, GW McCaughan, P Bertolino	Gastroenterology	2008
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 ME Kleinman, K Yamada, A Takeda, V Chandrasekaran, M Nozaki, JZ Baffi, RJ Albuquerque, S Yamasaki, M Itaya, Y Pan, B Appukuttan, D Gibbs, Z Yang, K Karikó, BK Ambati, TA Wilgus, LA DiPietro, E Sakurai, K Zhang, JR Smith, EW Taylor, J Ambati	Nature	2008
Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers M Nakamura, K Funami, A Komori, T Yokoyama, Y Aiba, A Araki, Y Takii, M Ito, M Matsuyama, M Koyabu, K Migita, K Taniguchi, H Fujioka, H Yatsuhashi, M Matsumoto, H Ishibashi, T Seya	Hepatology International	2008
Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation R Muthuswamy, J Urban, JJ Lee, TA Reinhart, D Bartlett, P Kalinski	Cancer research	2008
TLR3 signaling does not affect organ-specific immune responses to factor IX in AAV gene therapy O Cao, RW Herzog	Blood	2008
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire J Rice, ML Dossett, C Ohlén, SL Buchan, TJ Kendall, SN Dunn, FK Stevenson, PD Greenberg	European Journal of Immunology	2008
Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses S Zhou, A Halle, EA Kurt-Jones, AM Cerny, E Porpiglia, M Rogers, DT Golenbock, RW Finberg	Journal of Neuroimmunology	2008
Sensing of viral infection and activation of innate immunity by toll-like receptor 3 E Vercammen, J Staal, R Beyaert	Clinical microbiology reviews	2008
The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids A Egesten, M Eliasson, AI Olin, JS Erjefält, A Bjartell, P Sangfelt, M Carlson	International Journal of Colorectal Disease	2007
NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice R Zhou, H Wei, R Sun, J Zhang, Z Tian	Proceedings of the National Academy of Sciences	2007
Toll-like receptors and innate immune responses in systemic lupus erythematosus R Lafyatis, A Marshak-Rothstein	Arthritis Research & Therapy	2007
Experimental coronavirus retinopathy (ECOR): retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection B Detrick, MT Lee, MS Chin, LC Hooper, CC Chan, JJ Hooks	Journal of Neuroimmunology	2007
Autoimmunity stimulated by adoptively transferred dendritic cells is initiated by both alphabeta and gammadelta T cells but does not require MyD88 signaling. Martin DA, Zhang K, Kenkel J, Hughes G, Clark E, Davidson A, Elkon KB	Journal of immunology (Baltimore, Md. : 1950)	2007
Toll-like receptors and Interferon-alpha: partners in autoimmunity Marco Colonna	Journal of Clinical Investigation	2006

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