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Citations to this article

PPARγ and human metabolic disease
Robert K. Semple, … , V. Krishna K. Chatterjee, Stephen O’Rahilly
Robert K. Semple, … , V. Krishna K. Chatterjee, Stephen O’Rahilly
Published March 1, 2006
Citation Information: J Clin Invest. 2006;116(3):581-589. https://doi.org/10.1172/JCI28003.
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PPARγ and human metabolic disease

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Abstract

The nuclear receptor family of PPARs was named for the ability of the original member to induce hepatic peroxisome proliferation in mice in response to xenobiotic stimuli. However, studies on the action and structure of the 3 human PPAR isotypes (PPARα, PPARδ, and PPARγ) suggest that these moieties are intimately involved in nutrient sensing and the regulation of carbohydrate and lipid metabolism. PPARα and PPARδ appear primarily to stimulate oxidative lipid metabolism, while PPARγ is principally involved in the cellular assimilation of lipids via anabolic pathways. Our understanding of the functions of PPARγ in humans has been increased by the clinical use of potent agonists and by the discovery of both rare and severely deleterious dominant-negative mutations leading to a stereotyped syndrome of partial lipodystrophy and severe insulin resistance, as well as more common sequence variants with a much smaller impact on receptor function. These may nevertheless have much greater significance for the public health burden of metabolic disease. This Review will focus on the role of PPARγ in human physiology, with specific reference to clinical pharmacological studies, and analysis of PPARG gene variants in the abnormal lipid and carbohydrate metabolism of the metabolic syndrome.

Authors

Robert K. Semple, V. Krishna K. Chatterjee, Stephen O’Rahilly

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Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review
CS Paththinige, ND Sirisena, VH Dissanayake
Lipids in Health and Disease 2017
Immune and Metabolic Regulation Mechanism of Dangguiliuhuang Decoction against Insulin Resistance and Hepatic Steatosis
H Cao, L Tuo, Y Tuo, Z Xia, R Fu, Y Liu, Y Quan, J Liu, Z Yu, M Xiang
Frontiers in pharmacology 2017
Tissue Immunometabolism: Development, Physiology, and Pathobiology
K Man, VI Kutyavin, A Chawla
Cell Metabolism 2017
Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons:
JR Koethe, W McDonnell, A Kennedy, CO Abana, M Pilkinton, I Setliff, I Georgiev, L Barnett, CC Hager, R Smith, SA Kalams, A Hasty, S Mallal
Journal of acquired immune deficiency syndromes (1999) 2017
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease
T Kostrzewski, T Cornforth, SA Snow, L Ouro-Gnao, C Rowe, EM Large, DJ Hughes
World journal of gastroenterology : WJG 2017
Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPAR γ
DS Pan, W Wang, NS Liu, QJ Yang, K Zhang, JZ Zhu, S Shan, ZB Li, ZQ Ning, L Huang, XP Lu
PPAR Research 2017
The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia
K Chakraborty, M Raundhal, BB Chen, C Morse, YY Tyurina, A Khare, TB Oriss, R Huff, JS Lee, CM st. Croix, S Watkins, RK Mallampalli, VE Kagan, A Ray, P Ray
Nature Communications 2017
The gene-diet associations in postmenopausal women with newly diagnosed dyslipidemia
B Grygiel-Górniak, E Kaczmarek, M Mosor, J Przysławski, J Nowak
The journal of nutrition, health & aging 2017
Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents
ZA Sadeghabadi, M Nourbakhsh, M Alaee, B Larijani, M Razzaghy-Azar
Journal of Endocrinological Investigation 2017
Variability in responses observed in human white adipose tissue models
RD Abbott, FE Borowsky, CA Alonzo, A Zieba, I Georgakoudi, DL Kaplan
Journal of Tissue Engineering and Regenerative Medicine 2017
Gestational diabetes mellitus is associated with decreased adipose and placenta peroxisome proliferator-activator receptor γ expression in a Chinese population
Y Gao, R She, W Sha
Oncotarget 2017
New Transcriptional Reporters to Quantify and Monitor PPARγ Activity.
Degrelle SA, Shoaito H, Fournier T
PPAR Research 2017
Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice.
Zhou J, Burns MP, Huynh L, Villapol S, Taub DD, Saavedra JM, Blackman MR
Frontiers in Endocrinology 2017
Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer.
Goldstein JT, Berger AC, Shih J, Duke FF, Furst L, Kwiatkowski DJ, Cherniack AD, Meyerson M, Strathdee CA
Cancer research 2017
Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes.
Petrosino M, Lori L, Pasquo A, Lori C, Consalvi V, Minicozzi V, Morante S, Laghezza A, Giorgi A, Capelli D, Chiaraluce R
International journal of molecular sciences 2017
Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.
Balasubramanian P, Howell PR, Anderson RM
EBioMedicine 2017
Effect of zinc deprivation on the lipid metabolism of budding yeast.
Singh N, Yadav KK, Rajasekharan R
Current Genetics 2017
Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
JH Yu, SJ Song, A Kim, Y Choi, JW Seok, HJ Kim, YJ Lee, KS Lee, J Kim
Scientific Reports 2016
Leptin signalling pathways in hypothalamic neurons
O Kwon, KW Kim, MS Kim
Cellular and Molecular Life Sciences 2016
Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma
S Mathew, H Abdel-Hafiz, A Raza, K Fatima, I Qadri
World journal of hepatology 2016
Microarray analysis of gene expression in liver, adipose tissue and skeletal muscle in response to chronic dietary administration of NDGA to high-fructose fed dyslipidemic rats
H Zhang, WJ Shen, Y Li, A Bittner, S Bittner, J Tabassum, YF Cortez, FB Kraemer, S Azhar
Nutrition & Metabolism 2016
Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?
A Pap, I Cuaranta-Monroy, M Peloquin, L Nagy
International journal of molecular sciences 2016
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
JC Corona, MR Duchen
Free radical biology & medicine 2016
Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKT/GSK3 β and MAPK Signaling Pathways
WY Wei, ZG Ma, SC Xu, N Zhang, QZ Tang
PPAR Research 2016
Lipodystrophy Syndromes
I Hussain, A Garg
Endocrinology and metabolism clinics of North America 2016
Obese neuronal PPARγ knock-out mice are leptin sensitive but show impaired glucose tolerance and fertility
MO Fernandez, S Sharma, S Kim, E Rickert, K Hsueh, V Hwang, JM Olefsky, NJ Webster
Endocrinology 2016
Reduced circulating levels of sTWEAK are associated with NAFLD and may affect hepatocyte triglyceride accumulation
J Lozano-Bartolomé, G Llauradó, MM Rodriguez, JM Fernandez-Real, JF Garcia-Fontgivell, J Puig, E Maymó-Masip, J Vendrell, MR Chacón
International Journal of Obesity 2016
Effect of fragmented Lactobacillus amylovorus CP1563 on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial.
Nakamura F, Ishida Y, Aihara K, Sawada D, Ashida N, Sugawara T, Aoki Y, Takehara I, Takano K, Fujiwara S
Microbial Ecology in Health and Disease 2016
F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
KW Lee, SH Kwak, YD Koo, YK Cho, HM Lee, HS Jung, YM Cho, YJ Park, SS Chung, KS Park
Experimental & molecular medicine 2016
A Recipe Composed of Chinese Herbal Active Components Regulates Hepatic Lipid Metabolism of NAFLD In Vivo and In Vitro
Meng SX, Liu Q, Tang YJ, Wang WJ, Zheng QS, Tian HJ, Yao DS, Liu L, Peng JH, Zhao Y, Hu YY, Feng Q
BioMed Research International 2016
IL-15 Mediates Mitochondrial Activity through a PPARδ-Dependent-PPARα-Independent Mechanism in Skeletal Muscle Cells.
Thornton SM, Krolopp JE, Abbott MJ
PPAR Research 2016
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells.
Li JJ, Wang R, Lama R, Wang X, Floyd ZE, Park EA, Liao FF
Scientific Reports 2016
Structural dataset for the PPARγ V290M mutant.
Puhl AC, Webb P, Polikarpov I
Data in Brief 2016
Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine.
Suman S, Kumar S, Fornace AJ, Datta K
Scientific Reports 2016
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RA, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, Ruth KS, Padmanabhan S, Jukema JW, Palmer CC, Hattersley A, Freathy RM, Langenberg C, Wareham NJ, Wood AR, Murray A, Weedon MN, Sattar N, Pearson E, Scott RA, Frayling TM
Diabetes 2016
Metrnl: a secreted protein with new emerging functions.
Zheng SL, Li ZY, Song J, Liu JM, Miao CY
Acta Pharmacologica Sinica 2016
A clinical perspective of obesity, metabolic syndrome and cardiovascular disease.
Han TS, Lean ME
JRSM cardiovascular disease 2016
BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.
Relic B, Charlier E, Deroyer C, Malaise O, Neuville S, Desoroux A, Gillet P, de Seny D, Malaise MG
Oncotarget 2016
Interruptin B induces brown adipocyte differentiation and glucose consumption in adipose-derived stem cells.
Kaewsuwan S, Plubrukarn A, Utsintong M, Kim SH, Jeong JH, Cho JG, Park SG, Sung JH
Molecular medicine reports 2016
Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation
Z Ge, P Zhang, T Hong, S Tang, R Meng, Y Bi, D Zhu
Scientific Reports 2015
Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders
Ren, M Jiang, Y Huang, YL Yang, YQ Zhang
Clinical Medicine Insights. Oncology 2015
PPARγ Regulation in Hypertension and Metabolic Syndrome
M Stump, M Mukohda, C Hu, CD Sigmund
Current Hypertension Reports 2015
Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy
X Ma, P Lee, DJ Chisholm, DE James
Frontiers in Endocrinology 2015
Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions
WS Lee, J Kim
PPAR Research 2015
Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention
JT Keeney, S Ibrahimi, L Zhao
Journal of Alzheimer's disease : JAD 2015
Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?
M Laakso
Current Diabetes Reports 2015
The early origins of obesity and insulin resistance: timing, programming and mechanisms.
Nicholas LM, Morrison JL, Rattanatray L, Zhang S, Ozanne SE, McMillen IC
International Journal of Obesity 2015
PPARD +294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between PPARD +294T/C polymorphism and serum lipid profiles.
Luo CY, Liu CW, Ge L, Pang GF, Yang M, Hu CY, Lv ZP, Chen NY, Li HY, Wu HY, Wang YY, Yin RX, Pan SL, Peng JH
Lipids in Health and Disease 2015
In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols.
Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V
Drug design, development and therapy 2015
Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population.
Yu M, Gilbert S, Li Y, Zhang H, Qiao Y, Lu Y, Tang Y, Zhen Q, Cheng Y, Liu Y
Lipids in Health and Disease 2015
Effects of Maternal Obesity on Fetal Programming: Molecular Approaches.
Neri C, Edlow AG
Cold Spring Harbor Perspectives in Medicine 2015
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
He AY, Ning LJ, Chen LQ, Chen YL, Xing Q, Li JM, Qiao F, Li DL, Zhang ML, Du ZY
Physiological Reports 2015
Role of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndrome.
Dong C, Zhou H, Shen C, Yu LG, Ding Y, Zhang YH, Guo ZR
World journal of diabetes 2015
Undernutrition and stage of gestation influence fetal adipose tissue gene expression.
Wallace JM, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Luther JS, Horgan GW, Adam CL
Journal of molecular endocrinology 2015
Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis.
Liu C, Feng T, Zhu N, Liu P, Han X, Chen M, Wang X, Li N, Li Y, Xu Y, Si S
Scientific Reports 2015
Interplay between FGF21 and Insulin Action in the Liver for the Regulation of Metabolism
Brice Emanuelli, Sara Vienberg, Graham Smyth, Christine Cheng, Kristin Stanford, Manimozhiyan Arumugam, Mervyn D. Michael, Andrew Adams, Alexei Kharitonenkov, C. Ronald Kahn
Journal of Clinical Investigation 2014
Perivascular fat, AMP-activated protein kinase and vascular diseases: Perivascular fat and vascular diseases
TA Almabrouk, MA Ewart, IP Salt, S Kennedy
British Journal of Pharmacology 2014
Anticancer Activities of Pterostilbene-Isothiocyanate Conjugate in Breast Cancer Cells: Involvement of PPARγ
K Nikhil, S Sharan, AK Singh, A Chakraborty, P Roy, R Reddy
PloS one 2014
Impaired lipid and glucose homeostasis in hexabromocyclododecane-exposed mice fed a high-fat diet
R Yanagisawa, E Koike, TT Win-Shwe, M Yamamoto, H Takano
Environmental Health Perspectives 2014
Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease
MA Sharif, P Alov, V Vitcheva, I Pajeva, I Tsakovska
PPAR Research 2014
Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases.
Uittenbogaard M, Chiaramello A
Current pharmaceutical design 2014
Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats
BP Cummings, A Bettaieb, JL Graham, K Stanhope, FG Haj, PJ Havel
Journal of Endocrinology 2014
Peroxisome proliferator-activated receptors for hypertension
Usuda D, Kanda T
World journal of cardiology 2014
Heritability of fat accumulation in white adipocytes
Katz LS, Geras-Raaka E, Gershengorn MC
American journal of physiology. Endocrinology and metabolism 2014
Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes
Albert JS, Yerges-Armstrong LM, Horenstein RB, Pollin TI, Sreenivasan UT, Chai S, Blaner WS, Snitker S, O'Connell JR, Gong DW, Breyer RJ III, Ryan AS, McLenithan JC, Shuldiner AR, Sztalryd C, Damcott CM
The New England journal of medicine 2014
Minireview: Pathophysiological Roles of the TR4 Nuclear Receptor: Lessons Learned From Mice Lacking TR4
Lin SJ, Zhang Y, Liu NC, Yang DR, Li G, Chang C
Molecular Endocrinology 2014
PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
Gu SJ, Guo ZR, Zhou ZY, Hu XS, Wu M
Lipids in Health and Disease 2014
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM
Journal of Molecular Medicine 2014
Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex.
Litoff EJ, Garriott TE, Ginjupalli GK, Butler L, Gay C, Scott K, Baldwin WS
Gene 2014
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.
Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF, Dastani Z, Richards JB, Semple RK, Frayling TM
Diabetes 2014
PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells
HS Kim, YC Hwang, SH Koo, KS Park, MS Lee, KW Kim, MK Lee, G Sesti
PloS one 2013
Human adipose dynamics and metabolic health
B Feng, T Zhang, H Xu
Annals of the New York Academy of Sciences 2013
The orphan nuclear receptors at their 25-year reunion
SE Mullican, JR DiSpirito, MA Lazar
Journal of Molecular Endocrinology 2013
Adipose tissue inflammation in glucose metabolism
HL Kammoun, MJ Kraakman, MA Febbraio
Reviews in Endocrine and Metabolic Disorders 2013
PPARγ Activation Inhibits Growth and Survival of Human Endometriotic Cells by Suppressing Estrogen Biosynthesis and PGE2 Signaling
DI Lebovic, SK Kavoussi, JH Lee, SK Banu, JA Arosh
Endocrinology 2013
Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats
L Olivera-Castillo, A Davalos, G Grant, N Valadez-Gonzalez, J Montero, HA Barrera-Perez, Y Chim-Chi, MA Olvera-Novoa, V Ceja-Moreno, P Acereto-Escoffie, J Rubio-Piña, R Rodriguez-Canul, JM Lobaccaro
PloS one 2013
Lessons from mouse models of high-fat diet-induced NAFLD
A Nakamura, Y Terauchi
International journal of molecular sciences 2013
In Vivo Actions of Peroxisome Proliferator-Activated Receptors: Glycemic control, insulin sensitivity, and insulin secretion
R Eldor, RA DeFronzo, M Abdul-Ghani
Diabetes care 2013
Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?
SK Majumdar, SE Inzucchi
Endocrine 2013
Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies
T Nolis
Journal of Human Genetics 2013
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats
J Lamontagne, E Jalbert-Arsenault, E Pepin, ML Peyot, NB Ruderman, CJ Nolan, E Joly, SR Madiraju, V Poitout, M Prentki
Diabetes 2013
Novel putative mechanisms to link circadian clocks to healthy aging
A Popa-Wagner, B Catalin, AM Buga
Journal of Neural Transmission 2013
The Role of PPARs in Placental Immunology: A Systematic Review of the Literature
S Hutter, J Knabl, U Andergassen, U Jeschke
PPAR Research 2013
Effect of Dietary Cocoa Tea (Camellia ptilophylla) Supplementation on High-Fat Diet-Induced Obesity, Hepatic Steatosis, and Hyperlipidemia in Mice
XR Yang, E Wat, YP Wang, CH Ko, CM Koon, WS Siu, S Gao, DW Cheung, CB san Lau, CX Ye, PC Leung
Evidence-Based Complementary and Alternative Medicine 2013
Honokiol: a non-adipogenic PPARγ agonist from nature
AG Atanasov, JN Wang, SP Gu, J Bu, MP Kramer, L Baumgartner, N Fakhrudin, A Ladurner, C Malainer, A Vuorinen, SM Noha, S Schwaiger, JM Rollinger, D Schuster, H Stuppner, VM Dirsch, EH Heiss
Biochimica et Biophysica Acta 2013
PPAR-α as a key nutritional and environmental sensor for metabolic adaptation
AV Contreras, N Torres, AR Tovar
Advances in nutrition (Bethesda, Md.) 2013
Peroxisome proliferator-activated receptor γ agonist suppresses human telomerase reverse transcriptase expression and aromatase activity in eutopic endometrial stromal cells from endometriosis
Chang HJ, Lee JH, Hwang KJ, Kim MR, Yoo JH
Clinical and Experimental Reproductive Medicine 2013
Polyacetylenes from Notopterygium incisum–New Selective Partial Agonists of Peroxisome Proliferator-Activated Receptor-Gamma
Atanasov AG, Blunder M, Fakhrudin N, Liu X, Noha SM, Malainer C, Kramer MP, Cocic A, Kunert O, Schinkovitz A, Heiss EH, Schuster D, Dirsch VM, Bauer R
PloS one 2013
Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics
Liu L, Ma Y, Wang RL, Xu WR, Wang SQ, Chou KC
Drug design, development and therapy 2013
Inference of Cross-Level Interaction between Genes and Contextual Factors in a Matched Case-Control Metabolic Syndrome Study: A Bayesian Approach
Wang SH, Chen WJ, Chuang LM, Hsiao PC, Liu PH, Hsiao CK
PloS one 2013
Preclinical studies of a specific PPARγ modulator in the control of skin inflammation.
Mastrofrancesco A, Kovacs D, Sarra M, Bastonini E, Cardinali G, Aspite N, Camera E, Chavatte P, Desreumaux P, Monteleone G, Picardo M
Journal of Investigative Dermatology 2013
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
YJ Lee, EH Ko, JE Kim, E Kim, H Lee, H Choi, JH Yu, HJ Kim, JK Seong, KS Kim, J Kim
Proceedings of the National Academy of Sciences 2012
Nuclear Receptors in Nonalcoholic Fatty Liver Disease
JA López-Velázquez, LD Carrillo-Córdova, NC Chávez-Tapia, M Uribe, N Méndez-Sánchez
Journal of Lipids 2012
Leptin revisited: its mechanism of action and potential for treating diabetes
R Coppari, C Bjørbæk
Nature Reviews Drug Discovery 2012
Management of Non-alcoholic Fatty Liver Disease and Steatohepatitis
TA Le, R Loomba
Journal of Clinical and Experimental Hepatology 2012
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet
JK Pepping, LR Freeman, S Gupta, JN Keller, AJ Bruce-Keller
American journal of physiology. Endocrinology and metabolism 2012
Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice
DH Lee, H Huang, K Choi, C Mantzoros, YB Kim
American journal of physiology. Endocrinology and metabolism 2012
Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders
YC Chen, JS Wu, HD Tsai, CY Huang, JJ Chen, GY Sun, TN Lin
Molecular Neurobiology 2012
Lipoprotein metabolism in nonalcoholic fatty liver disease
ZG Jiang, SC Robson, Z Yao
Journal of Biomedical Research 2012
Regulation of Chemokine and Chemokine Receptor Expression by PPARγ in Adipocytes and Macrophages
MT Nguyen, A Chen, WJ Lu, W Fan, PP Li, DY Oh, D Patsouris
PloS one 2012
Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside
F Zhang, D Kong, Y Lu, S Zheng
Cellular and Molecular Life Sciences 2012
Idealized PPARγ-Based Therapies: Lessons from Bench and Bedside
AA Amato, FA Neves
PPAR Research 2012
Physiological Responses to Acute Psychological Stress Are Reduced by the PPARγ Agonist Rosiglitazone
KK Ryan, BE Grayson, KR Jones, AL Schneider, SC Woods, RJ Seeley, JP Herman, YM Ulrich-Lai
Endocrinology 2012
The C-681G polymorphism of PPAR-γ gene is associated with susceptibility to non-alcoholic fatty liver disease
Cao CY, Li YY, Zhou YJ, Nie YQ, Yvonne Wan YJ
The Tohoku Journal of Experimental Medicine 2012
PPARγ and Stress: Implications for Aging
Ulrich-Lai YM, Ryan KK
Experimental Gerontology 2012
In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist
He BK, Ning ZQ, Li ZB, Shan S, Pan DS, Ko BC, Li PP, Shen ZF, Dou GF, Zhang BL, Lu XP, Gao Y
PPAR Research 2012
Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation
Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C, Mobasheri A
PloS one 2012
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN CARCINOGENESIS AND CHEMOPREVENTION
Peters JM, Shah YM, Gonzalez FJ
Nature reviews. Cancer 2012
Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches.
Aguilar-Gallardo C, Rutledge EC, Martínez-Arroyo AM, Hidalgo JJ, Domingo S, Simón C
Stem Cell Reviews and Reports 2012
Circadian Rhythms, Sleep, and Metabolism
Wenyu Huang, Kathryn Ramsey, Biliana Marcheva, Joseph Bass
Journal of Clinical Investigation 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
A role for CNS PPARγ in the regulation of energy balance
KK Ryan, B Li, BE Grayson, EK Matter, SC Woods, RJ Seeley
Nature Medicine 2011
Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview
RJ Chen, LW Chang, P Lin, YJ Wang
Journal of Oncology 2011
Proteomic Analysis Yields an Unexpected Trans -Acting Point in Control of the Human Sympathochromaffin Phenotype
S Chiron, Z Wei, Y Chen, K Zhang, Wen, WH Fischer, SK Mahata, DT OConnor
Circulation. Cardiovascular genetics 2011
Regulation of adipogenesis by nuclear receptor PPARγ is modulated by the histone demethylase JMJD2C
F Lizcano, C Romero, D Vargas
Genetics and molecular biology 2011
Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones
M Lu, DA Sarruf, S Talukdar, S Sharma, P Li, G Bandyopadhyay, S Nalbandian, WQ Fan, JR Gayen, SK Mahata, NJ Webster, MW Schwartz, JM Olefsky
Nature Medicine 2011
PPARδ regulates satellite cell proliferation and skeletal muscle regeneration
AR Angione, C Jiang, D Pan, YX Wang, S Kuang
Skeletal Muscle 2011
Lipodystrophies: Genetic and Acquired Body Fat Disorders
A Garg
The Journal of clinical endocrinology and metabolism 2011
Regulation of chemokine and chemokine receptor expression by PPARG in adipocytes and macrophages
Nguyen MA, Chen A, Lu WJ, Fan W, Li PP, Oh D, Patsouris D
Journal of Translational Medicine 2011
Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver
Y Zhang, C Shen, D Ai, X Xie, Y Zhu
PPAR Research 2011
Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk
A Alsaleh, SD O'Dell, GS Frost, BA Griffin, JA Lovegrove, SA Jebb, TA Sanders,
Journal of lipid research 2011
Maternal Omega-3 Supplementation Increases Fat Mass in Male and Female Rat Offspring
Muhlhausler BS, Miljkovic D, Fong L, Xian CJ, Duthoit E, Gibson RA
Frontiers in Genetics 2011
PPAR-γ action: it's all in your head.
Myers MG Jr, Burant CF
Nature Medicine 2011
Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes.
Costa Cdos S, Rohden F, Hammes TO, Margis R, Bortolotto JW, Padoin AV, Mottin CC, Guaragna RM
Obesity surgery 2011
Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function
JM Juang, L las Fuentes, AD Waggoner, CC Gu, VG Dávila-Román
BMC Medical Genetics 2010
PPARs: diverse regulators in energy metabolism and metabolic diseases
YX Wang
Cell Research 2010
Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity
WA Chutkow, AL Birkenfeld, JD Brown, HY Lee, DW Frederick, J Yoshioka, P Patwari, R Kursawe, SW Cushman, J Plutzky, GI Shulman, VT Samuel, RT Lee
Diabetes 2010
Anticancer actions of PPARγ ligands: Current state and future perspectives in human lung cancer
SW Han, J Roman
World journal of biological chemistry 2010
Transcriptional factors that promote formation of white adipose tissue
UA White, JM Stephens
Molecular and Cellular Endocrinology 2010
Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease
S Azhar
Future Cardiology 2010
Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities
CJ Omiecinski, JP Heuvel, GH Perdew, JM Peters
Toxicological Sciences 2010
PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice
A Foryst-Ludwig, M Hartge, M Clemenz, C Sprang, K Hess, N Marx, T Unger, U Kintscher
Cardiovascular Diabetology 2010
Thiazolidinediones Up-regulate Insulin-like Growth Factor-1 Receptor via a Peroxisome Proliferator-activated Receptor γ-Independent Pathway*
Y Higashi, K Holder, P Delafontaine
The Journal of biological chemistry 2010
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
N Zhang, Z Fu, S Linke, J Chicher, JJ Gorman, DA Visk, GG Haddad, L Poellinger, DJ Peet, F Powell, RS Johnson
Cell Metabolism 2010
Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages
TH Mayi, C Duhem, C Copin, MA Bouhlel, E Rigamonti, F Pattou, B Staels, G Chinetti-Gbaguidi
The FEBS journal 2010
Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism
T Goto, N Takahashi, S Hirai, T Kawada
PPAR Research 2010
Evaluation of single nucleotide polymorphisms of Pro12Ala in peroxisome proliferator-activated receptor-γ and Gly308Ala in tumor necrosis factor-α genes in obese Asian Indians: a population-based study
Bhagat N, Agrawal M, Luthra K, Vikram NK, Misra A, Gupta R
Diabetes, metabolic syndrome and obesity : targets and therapy 2010
Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes
Poleni PE, Etienne S, Velot E, Netter P, Bianchi A
PPAR Research 2010
Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues
Abbott BD, Wood CR, Watkins AM, Das KP, Lau CS
PPAR Research 2010
Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice
Dobrzyn P, Dobrzyn A, Miyazaki M, Ntambi JM
Journal of lipid research 2010
Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies
Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE
The American Journal of Human Genetics 2010
Pharmacophore-driven identification of PPARγ agonists from natural sources.
Petersen RK, Christensen KB, Assimopoulou AN, Fretté X, Papageorgiou VP, Kristiansen K, Kouskoumvekaki I
Journal of Computer-Aided Molecular Design 2010
Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects.
Tinahones FJ, Garrido-Sanchez L, Miranda M, García-Almeida JM, Macias-Gonzalez M, Ceperuelo V, Gluckmann E, Rivas-Marin J, Vendrell J, García-Fuentes E
Obesity surgery 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
SJ Greco, S Sarkar, JM Johnston, N Tezapsidis
Biochemical and Biophysical Research Communications 2009
Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic β-Cell at Submaximal Glucose Concentrations
J Lamontagne, E Pepin, ML Peyot, E Joly, NB Ruderman, V Poitout, SR Madiraju, CJ Nolan, M Prentki
Endocrinology 2009
Mechanisms of the noxious inflammatory cycle in cystic fibrosis
M Rottner, JM Freyssinet, MC Martínez
Respiratory Research 2009
Lipodystrophies: Disorders of adipose tissue biology
A Garg, AK Agarwal
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2009
The Multiple Endocrine Neoplasia Type 1 (MEN1) Tumor Suppressor Regulates Peroxisome Proliferator-Activated Receptor γ-Dependent Adipocyte Differentiation
KM Dreijerink, RA Varier, O van Beekum, EH Jeninga, JW Höppener, CJ Lips, JA Kummer, E Kalkhoven, HT Timmers
Molecular and cellular biology 2009
Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins
A González-Périz, R Horrillo, N Ferré, K Gronert, B Dong, E Morán-Salvador, E Titos, M Martínez-Clemente, M López-Parra, V Arroyo, J Clària
The FASEB Journal 2009
Mitochondria and diabetes mellitus: untangling a conflictive relationship?
M Schiff, S Loublier, A Coulibaly, P Bénit, HO de Baulny, P Rustin
Journal of Inherited Metabolic Disease 2009
The protein kinase IKKepsilon regulates energy balance in obese mice
SH Chiang, M Bazuine, CN Lumeng, LM Geletka, J Mowers, NM White, JT Ma, J Zhou, N Qi, D Westcott, JB Delproposto, TS Blackwell, FE Yull, AR Saltiel
Cell 2009
Ligand-Activated Peroxisome Proliferator–Activated Receptor-γ Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3ε Upregulation
JS Wu, WM Cheung, YS Tsai, YT Chen, WH Fong, HD Tsai, YC Chen, JY Liou, SK Shyue, JJ Chen, YE Chen, N Maeda, KK Wu, TN Lin
Circulation 2009
Nicotinic Acid-Mediated Activation of Both Membrane and Nuclear Receptors towards Therapeutic Glucocorticoid Mimetics for Treating Multiple Sclerosis
WT Penberthy
PPAR Research 2009
The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes
II Ahmetov, AG Williams, DV Popov, EV Lyubaeva, AM Hakimullina, ON Fedotovskaya, IA Mozhayskaya, OL Vinogradova, IV Astratenkova, HE Montgomery, VA Rogozkin
Human Genetics 2009
Nicotine Stimulates PPARβ/δ Expression in Human Lung Carcinoma Cells through Activation of PI3K/mTOR and Suppression of AP-2α
XJ Sun, JD Ritzenthaler, XR Zhong, Y Zheng, J Roman, SW Han
Cancer research 2009
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC
Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magré J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S, Savage DB
EMBO Molecular Medicine 2009
HIV-1 Infection and the PPARγ-Dependent Control of Adipose Tissue Physiology
M Giralt, P Domingo, F Villarroya
PPAR Research 2009
C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
VA Payne, WS Au, CE Lowe, SM Rahman, JE Friedman, S O'Rahilly, JJ Rochford
Biochemical Journal 2009
Redox characterization of the FeS protein mitoNEET and impact of thiazolidinedione drug binding
Bak DW, Zuris JA, Paddock ML, Jennings PA, Elliott SJ
Biochemistry 2009
Long-term effects of lifestyle on multiple risk factors in male workers
Koetaka H, Ohno Y, Morimoto K
Environmental Health and Preventive Medicine 2009
Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFκB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus
Bragt MC, Plat J, Mensink M, Schrauwen P, Mensink RP
BMC Endocrine Disorders 2009
SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.
Costa Cdos S, Hammes TO, Rohden F, Margis R, Bortolotto JW, Padoin AV, Mottin CC, Guaragna RM
Obesity surgery 2009
Hexarelin Signaling to PPARγ in Metabolic Diseases
A Demers, A Rodrigue-Way, A Tremblay
PPAR Research 2008
Endogenous Peroxisome Proliferator-Activated Receptor-γ Augments Fatty Acid Uptake in Oxidative Muscle
AW Norris, MF Hirshman, J Yao, N Jessen, N Musi, L Chen, WI Sivitz, LJ Goodyear, CR Kahn
Endocrinology 2008
Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis
D Genini, GM Carbone, CV Catapano
PPAR Research 2008
Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells
SW Han, J Roman
PPAR Research 2008
Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients: Alteration of the PPARgamma-Dependent Pathways
M Caron, C Vigouroux, JP Bastard, J Capeau
PPAR Research 2008
PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
J Yang, L Chen, X Zhang, Y Zhou, D Zhang, M Huo, Y Guan
PPAR Research 2008
PPARγ agonists and coronary atherosclerosis
MS Sulistio, A Zion, N Thukral, R Chilton
Current Atherosclerosis Reports 2008
Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines
C Guo, V Ricchiuti, BQ Lian, TM Yao, P Coutinho, JR Romero, J Li, GH Williams, GK Adler
Circulation 2008
PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents
A Pozzi, JH Capdevila
PPAR Research 2008
Adiponectin promotes endothelial progenitor cell number and function
R Shibata, C Skurk, N Ouchi, G Galasso, K Kondo, T Ohashi, M Shimano, S Kihara, T Murohara, K Walsh
FEBS Letters 2008
Lipodystrophy Syndromes
P Herranz, R Lucas, L Pérez-España, M Mayor
Dermatologic Clinics 2008
The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer
LS Higgins, CS Mantzoros
PPAR Research 2008
Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma
A Foryst-Ludwig, M Clemenz, S Hohmann, M Hartge, C Sprang, N Frost, M Krikov, S Bhanot, R Barros, A Morani, JA Gustafsson, T Unger, U Kintscher
PLoS genetics 2008
New drugs for type 2 diabetes mellitus: what is their place in therapy?
Krentz AJ, Patel MB, Bailey CJ
Drugs 2008
Should We Use PPAR Agonists to Reduce Cardiovascular Risk?
Robinson JG
PPAR Research 2008
Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Rector RS, Thyfault JP, Laye MJ, Morris RT, Borengasser SJ, Uptergrove GM, Chakravarthy MV, Booth FW, Ibdah JA
The Journal of Physiology 2008
Activation of Peroxisome Proliferator–Activated Receptor β/δ Induces Lung Cancer Growth via Peroxisome Proliferator–Activated Receptor Coactivator γ-1α
Han S, Ritzenthaler JD, Sun X, Zheng Y, Roman J
American journal of respiratory cell and molecular biology 2008
Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
Ruiz JR, Labayen I, Ortega FB, Moreno LA, González-Lamuño D, Martí A, Nova E, Fuentes MG, Redondo-Figuero C, Martínez JA, Sjöström M, Castillo MJ
BMC Medical Genetics 2008
Role of the Molybdoflavoenzyme Aldehyde Oxidase Homolog 2 in the Biosynthesis of Retinoic Acid: Generation and Characterization of a Knockout Mouse
Terao M, Kurosaki M, Barzago MM, Fratelli M, Bagnati R, Bastone A, Giudice C, Scanziani E, Mancuso A, Tiveron C, Garattini E
Molecular and cellular biology 2008
Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy
Costa V, Casamassimi A, Esposito K, Villani A, Capone M, Iannella R, Schisano B, Ciotola M, Di Palo C, Capone Corrado F, Santangelo F, Giugliano D, Ciccodicola A
Journal of Biomedicine and Biotechnology 2008
Critical Role of PPAR-α in Perfluorooctanoic Acid– and Perfluorodecanoic Acid–Induced Downregulation of Oatp Uptake Transporters in Mouse Livers
Cheng X, Klaassen CD
Toxicological Sciences 2008
PPARγ and Proline Oxidase in Cancer
Phang JM, Pandhare J, Zabirnyk O, Liu Y
PPAR Research 2008
The Role of PPAR-γ and Its Interaction with COX-2 in Pancreatic Cancer
Eibl G
PPAR Research 2008
Nuclear receptor profile in calvarial bone cells undergoing osteogenic versus adipogenic differentiation.
Pirih FQ, Abayahoudian R, Elashoff D, Parhami F, Nervina JM, Tetradis S
Journal of Cellular Biochemistry 2008
Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity.
Lindgren CM, McCarthy MI
Nature clinical practice. Endocrinology & metabolism 2008
Energy Balance, Myostatin, and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone
X Shi, M Hamrick, CM Isales
PPAR Research 2007
Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis
VA Payne, WS Au, SL Gray, ED Nora, SM Rahman, R Sanders, D Hadaschik, JE Friedman, S O'rahilly, JJ Rochford
The Journal of biological chemistry 2007
Peroxisome proliferator-activated receptors in lung cancer
VG Keshamouni, S Han, J Roman
PPAR Research 2007
PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study
DI Lebovic, JM Mwenda, DC Chai, MD Mueller, A Santi, S Fisseha, T D'Hooghe
Fertility and Sterility 2007
PPARgamma in human and mouse physiology
S Heikkinen, J Auwerx, CA Argmann
Biochimica et Biophysica Acta 2007
Nuclear receptors: decoding metabolic disease
J Sonoda, L Pei, RM Evans
FEBS Letters 2007
Genetic links between diabetes mellitus and coronary atherosclerosis
JM Ordovas
Current Atherosclerosis Reports 2007
APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study.
Corella D, Lai CQ, Demissie S, Cupples LA, Manning AK, Tucker KL, Ordovas JM
Journal of Molecular Medicine 2007
Downregulation of plasma insulin levels and hepatic PPARgamma expression during the first week of caloric restriction in mice.
Mulligan JD, Stewart AM, Saupe KW
Experimental Gerontology 2007
The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice.
Holguin F, Rojas M, Hart CM
Lung 2007
Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins.
Lin J, Zhou T, Ye K, Wang J
Proceedings of the National Academy of Sciences 2007
Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.
Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH
Environmental Health Perspectives 2007
Association between cancer prevalence and use of thiazolidinediones: results from the Vermont Diabetes Information System.
Ramos-Nino ME, MacLean CD, Littenberg B
BMC Medicine 2007
Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people.
Grarup N, Albrechtsen A, Ek J, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O
Diabetologia 2007
The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention.
Rittig K, Thamer C, Machicao F, Rietig R, Stefan N, Fritsche A, Haring HU, Balletshofer B
Diabetologia 2007
Update on PPAR agonists: the clinical significance of FIELD and PROACTIVE.
Robinson JG
Current Atherosclerosis Reports 2007
PGC-1alpha controls hepatitis B virus through nutritional signals
A Shlomai, N Paran, Y Shaul
Proceedings of the National Academy of Sciences 2006
Cellular and Molecular Consequences of Peroxisome Proliferator-Activated Receptor-γ Activation in Ovarian Cancer Cells
Vignati S, Albertini V, Rinaldi A, Kwee I, Riva C, Oldrini R, Capella C, Bertoni F, Carbone GM, Catapano CV
Neoplasia (New York, N.Y.) 2006
Going nuclear in metabolic and cardiovascular disease
CK Glass
Journal of Clinical Investigation 2006

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