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Citations to this article

Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+ /calmodulin-dependent protein kinase II
Junlan Yao, … , Roger J. Colbran, Paula Q. Barrett
Junlan Yao, … , Roger J. Colbran, Paula Q. Barrett
Published September 1, 2006
Citation Information: J Clin Invest. 2006;116(9):2403-2412. https://doi.org/10.1172/JCI27918.
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Research Article Cardiology

Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+ /calmodulin-dependent protein kinase II

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Abstract

Ang II receptor activation increases cytosolic Ca2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic stimulus that adversely influences cardiovascular homeostasis. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a downstream effector of the Ang II–elicited signaling cascade that serves as a key intracellular Ca2+ sensor to feedback-regulate Ca2+ entry through voltage-gated Ca2+ channels. However, the molecular mechanism(s) by which CaMKII regulates these important physiological targets to increase Ca2+ entry remain unresolved. We show here that CaMKII forms a signaling complex with α1H T-type Ca2+ channels, directly interacting with the intracellular loop connecting domains II and III of the channel pore (II-III loop). Activation of the kinase mediated the phosphorylation of Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cells in situ and in cells of the native adrenal zona glomerulosa stimulated by Ang II in vivo. These data define the molecular basis for the in vivo modulation of native T-type Ca2+ channels by CaMKII and suggest that the disruption of this signaling complex in the zona glomerulosa may provide a new therapeutic approach to limit aldosterone production and cardiovascular disease progression.

Authors

Junlan Yao, Lucinda A. Davies, Jason D. Howard, Scott K. Adney, Philip J. Welsby, Nancy Howell, Robert M. Carey, Roger J. Colbran, Paula Q. Barrett

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Total citations by year

Year: 2024 2023 2022 2021 2019 2017 2016 2015 2014 2013 2012 2011 2009 2008 Total
Citations: 2 3 2 1 3 1 1 4 3 2 3 3 3 1 32
Citation information
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Citations to this article (32)

Title and authors Publication Year
Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase
Zhao S, Xiong Y, Sunnapu R, Zhang Y, Tian X, Ai HW
2024
Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase
Zhao S, Xiong Y, Sunnapu R, Zhang Y, Tian X, Ai HW
Journal of the American Chemical Society 2024
Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones
Sharma A, Rahman G, Gorelik J, Bhargava A
Cells 2023
Identification of Novel Targeting Sites of Calcineurin and CaMKII in Human CaV3.2 T-Type Calcium Channel
Chang YW, Chen YC, Chen CC
Biomedicines 2023
The T-type calcium channelosome.
Weiss N, Zamponi GW
2023
Aldosterone-Regulated Sodium Transport and Blood Pressure
Tsilosani A, Gao C, Zhang W
Frontiers in physiology 2022
Calcium/calmodulin-dependent protein kinase II associates with the K+ channel isoform Kv4.3 in adult rat optic nerve
Ogata G, Partida GJ, Fasoli A, Ishida AT
Frontiers in neuroanatomy 2022
Ion Channel Function and Electrical Excitability in the Zona Glomerulosa: A Network Perspective on Aldosterone Regulation
PQ Barrett, NA Guagliardo, DA Bayliss
Annual Review of Physiology 2021
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels
J Chemin, TT Stamenic, M Cazade, J Llinares, I Blesneac, SM Todorovic, P Lory
Scientific Reports 2019
Cdk5-Dependent Phosphorylation of CaV3.2 T-Type Channels: Possible Role in Nerve Ligation-Induced Neuropathic Allodynia and the Compound Action Potential in Primary Afferent C Fibers.
Gomez K, Calderón-Rivera A, Sandoval A, González-Ramírez R, Vargas-Parada A, Ojeda-Alonso J, Granados-Soto V, Delgado-Lezama R, Felix R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019
Activation of alpha-1 adrenergic receptors increases cytosolic calcium in neurones of the paraventricular nucleus of the hypothalamus.
Milanick WJ, Polo-Parada L, Dantzler HA, Kline DD
Journal of Neuroendocrinology 2019
T-type Ca 2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling
L Kisiswa, C Erice, L Ferron, S Wyatt, C Osório, AC Dolphin, AM Davies
Open Biology 2017
Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex: Voltage-gated channels in the regulation of aldosterone
PQ Barrett, NA Guagliardo, PM Klein, C Hu, DT Breault, MP Beenhakker
The Journal of Physiology 2016
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
GW Zamponi, J Striessnig, A Koschak, AC Dolphin
Pharmacological reviews 2015
Ca V 3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy
G Wang, G Bochorishvili, Y Chen, KA Salvati, P Zhang, SJ Dubel, E Perez-Reyes, TP Snutch, RL Stornetta, K Deisseroth, A Erisir, SM Todorovic, JH Luo, J Kapur, MP Beenhakker, JJ Zhu
Genes & development 2015
Differential CaMKII regulation by voltage-gated calcium channels in the striatum
JG Pasek, X Wang, RJ Colbran
Molecular and Cellular Neuroscience 2015
Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties
I Blesneac, J Chemin, I Bidaud, S Huc-Brandt, F Vandermoere, P Lory
Proceedings of the National Academy of Sciences 2015
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage
SS Lin, BH Tzeng, KR Lee, RJ Smith, KP Campbell, CC Chen
Proceedings of the National Academy of Sciences 2014
CaMKII in sinoatrial node physiology and dysfunction
Y Wu, ME Anderson
Frontiers in pharmacology 2014
The Involvement of Nek2 and Notch in the Proliferation of Rat Adrenal Cortex Triggered by POMC-Derived Peptides
PO de Mendonca, IC Costa, CF Lotfi, FD Cunto
PloS one 2014
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics
J Akerboom, NC Calderón, L Tian, S Wabnig, M Prigge, J Tolö, A Gordus, MB Orger, KE Severi, JJ Macklin, R Patel, SR Pulver, TJ Wardill, E Fischer, C Schüler, TW Chen, KS Sarkisyan, JS Marvin, CI Bargmann, DS Kim, S Kügler, L Lagnado, P Hegemann, A Gottschalk, ER Schreiter, LL Looger
Frontiers in molecular neuroscience 2013
Molecular determinants for cardiovascular TRPC6 channel regulation by Ca 2+ /calmodulin-dependent kinase II: Molecular mechanism for CaMKII-mediated TRPC6 regulation
J Shi, N Geshi, S Takahashi, S Kiyonaka, J Ichikawa, Y Hu, Y Mori, Y Ito, R Inoue
The Journal of Physiology 2013
Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators
Changlong Hu, Craig Rusin, Zhiyong Tan, Nick Guagliardo, Paula Barrett
Journal of Clinical Investigation 2012
Aldosterone and cardiovascular disease: the heart of the matter
BJ He, ME Anderson
Trends in Endocrinology & Metabolism 2012
Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis
K Oki, MW Plonczynski, ML Lam, EP Gomez-Sanchez, CE Gomez-Sanchez
Endocrinology 2012
Acute and Chronic Regulation of Aldosterone Production
NG Hattangady, LO Olala, WB Bollag, WE Rainey
Molecular and Cellular Endocrinology 2011
Ca2+-dependent modulation of voltage-gated Ca2+ channels
C Christel, A Lee
Biochimica et Biophysica Acta 2011
Voltage-gated calcium channels
WA Catterall
Cold Spring Harbor perspectives in biology 2011
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Supramolecular assemblies and localized regulation of voltage-gated ion channels
S Dai, DD Hall, JW Hell
Physiological reviews 2009
Protein kinase A activity controls the regulation of T-type CaV3.2 channels by Gbetagamma dimers
C Hu, SD Depuy, J Yao, WE McIntire, PQ Barrett
The Journal of biological chemistry 2009
Differential Regulated Interactions of Calcium/Calmodulin-Dependent Protein Kinase II with Isoforms of Voltage-Gated Calcium Channel β Subunits
CE Grueter, SA Abiria, Y Wu, ME Anderson, RJ Colbran
Biochemistry 2008

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