Glucagon-like peptide–1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non–insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors’ work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.
David A. D’Alessio, Darleen A. Sandoval, Randy J. Seeley
Title and authors | Publication | Year |
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Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity
X Shi, S Chacko, F Li, D Li, D Burrin, L Chan, X Guan |
Molecular Metabolism | 2017 |
Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents
PM Ryan, E Patterson, RM Kent, H Stack, PM OConnor, K Murphy, VL Peterson, R Mandal, DS Wishart, TG Dinan, JF Cryan, RJ Seeley, C Stanton, RP Ross |
Scientific Reports | 2017 |