Platelets in inflammation and atherogenesis
Meinrad Gawaz, … , Harald Langer, Andreas E. May
Meinrad Gawaz, … , Harald Langer, Andreas E. May
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3378-3384. https://doi.org/10.1172/JCI27196.
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Review Series

Platelets in inflammation and atherogenesis

Abstract

Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.

Authors

Meinrad Gawaz, Harald Langer, Andreas E. May

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Figure 1

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Platelet-endothelium adhesion. Activated endothelium surface expresses P...
Platelet-endothelium adhesion. Activated endothelium surface expresses P-selectin. Platelet surface receptors GPIbα and PSGL-1 interact with endothelial P-selectin and mediate platelet rolling. Subsequent firm adhesion is mediated through β3 integrins.