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Ilona Bodi, … , Shahab A. Akhter, Arnold Schwartz
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3306-3317. https://doi.org/10.1172/JCI27167.
Citation Information: J Clin Invest. 2005;115(12):3306-3317. https://doi.org/10.1172/JCI27167.
Abstract
Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
Authors
Ilona Bodi, Gabor Mikala, Sheryl E. Koch, Shahab A. Akhter, Arnold Schwartz
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Citation information
Citations to this article (242)
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Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling
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Journal of the American College of Cardiology | 2015 |
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The relationship of stress and blood pressure effectors
C Ayada, Ü Toru, Y Korkut |
Hippokratia | 2015 |
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Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation
E Kobrinsky |
Current molecular pharmacology | 2015 |
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Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
E Choi, MJ Cha, KC Hwang |
Cells | 2014 |
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Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates
B Song, Y Liu, T Parman, S Liu, JK Miller, X Liu, MJ Tanga, J Mirsalis |
Journal of Proteome Research | 2014 |
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Functional Characterization of Ca V α2δ Mutations Associated with Sudden Cardiac Death
B Bourdin, B Shakeri, MP Tétreault, R Sauvé, S Lesage, L Parent |
The Journal of biological chemistry | 2014 |
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Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart
H Luo, J Si, F Zhang, Z Yang, R Wang |
Experimental and therapeutic medicine | 2014 |
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Cardiac Electrophysiology: From Cell to Bedside
F Yang, MP Turakhia, VF Froelicher |
Cardiac Electrophysiology: From Cell to Bedside | 2014 |
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Glutathionylation of the L-type Ca2+ Channel in Oxidative Stress-Induced Pathology of the Heart
V Johnstone, L Hool |
International journal of molecular sciences | 2014 |
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Effects of L-type calcium channel and human ether-a-go-go related gene blockers on the electrical activity of the human heart: a simulation study
N Zemzemi, B Rodriguez |
Europace | 2014 |
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How Does Calcium Regulate Mitochondrial Energetics in the Heart? – New Insights
HM Viola, LC Hool |
Heart, Lung and Circulation | 2014 |
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Cardiac ablation of Rheb1 reduces sodium currents in infant mice
H Wu, ZL Han, YS Cao, S Lin, X Li |
International journal of clinical and experimental medicine | 2014 |
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Direct Interaction of Ca V β with Actin Up-regulates L-type Calcium Currents in HL-1 Cardiomyocytes
G Stölting, RC de Oliveira, RE Guzman, E Miranda-Laferte, R Conrad, N Jordan, S Schmidt, J Hendriks, T Gensch, P Hidalgo |
The Journal of biological chemistry | 2014 |
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The PDZ Motif of the α 1C Subunit Is Not Required for Surface Trafficking and Adrenergic Modulation of Ca V 1.2 Channel in the Heart
L Yang, A Katchman, RL Weinberg, J Abrams, T Samad, E Wan, GS Pitt, SO Marx |
The Journal of biological chemistry | 2014 |
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Rear-fanged snake venoms: an untapped source of novel compounds and potential drug leads
AJ Saviola, ME Peichoto, SP Mackessy |
Toxin Reviews | 2014 |
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Alterations in Ryanodine Receptors and Related Proteins in Heart Failure
S Ather, JL Respress, N Li, XH Wehrens |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
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Calcineurin-dependent ion channel regulation in heart
Y Wang, S Tandan, JA Hill |
Trends in Cardiovascular Medicine | 2013 |
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MKP3 eliminates depolarization-dependent neurotransmitter release through downregulation of L-type calcium channel Cav1.2 expression
OV Mortensen |
Cell Calcium | 2013 |
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A macromolecular trafficking complex composed of β 2 -adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels
R Flynn, C Altier |
Journal of Receptors and Signal Transduction | 2013 |
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Role of the cytoskeleton in communication between L-type Ca 2+ channels and mitochondria
HM Viola, LC Hool |
Clinical and Experimental Pharmacology and Physiology | 2013 |
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Calmodulin in a Heartbeat
AB Sorensen, MT Søndergaard, MT Overgaard |
FEBS Journal | 2013 |
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Aging-associated changes in L-type calcium channels in the left atria of dogs
TY Gan, W Qiao, GJ Xu, XH Zhou, BP Tang, JG Song, YD Li, J Zhang, FP Li, T Mao, T Jiang |
Experimental and therapeutic medicine | 2013 |
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Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies
JJ Hornberg, M Laursen, N Brenden, M Persson, AV Thougaard, DB Toft, T Mow |
Drug Discovery Today | 2013 |
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Molecular changes in the early phase of renin-dependent cardiac hypertrophy in hypertensive cyp1a1 ren-2 transgenic rats
C Kunert-Keil, M Landsberger, F Jantzen, F Niessner, HK Kroemer, SB Felix, H Brinkmeier, J Peters |
Journal of Renin-Angiotensin-Aldosterone System | 2013 |
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β-Adrenergic Regulation of the L-type Ca 2+ Channel Does Not Require Phosphorylation of α 1C Ser 1700
L Yang, A Katchman, T Samad, JP Morrow, RL Weinberg, SO Marx |
Circulation research | 2013 |
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Pathologies of Calcium Channels
N Weiss, A Koschak |
2013 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Calcium Signaling
S Islam |
2012 | |
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Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling
H Gao, F Wang, W Wang, CA Makarewich, H Zhang, H Kubo, RM Berretta, LA Barr, JD Molkentin, SR Houser |
Journal of Molecular and Cellular Cardiology | 2012 |
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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
DJ Dupré, TE Hébert, R Jockers |
2012 | |
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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
DJ Dupré, TE Hébert, R Jockers |
2012 | |
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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
DJ Dupré, TE Hébert, R Jockers |
2012 | |
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MicroRNA regulation of cardiac conduction and arrhythmias
GH Kim |
Translational Research | 2012 |
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Speed, adaptation, and stability of the response to light in cone photoreceptors: The functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels
JI Korenbrot |
The Journal of General Physiology | 2012 |
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Comprehensive Biophysics
AM Weinstein |
Comprehensive Biophysics | 2012 |
|
Muscle
ML Martin, SL Belmonte, R Ram, FA Kamal, BC Blaxall |
Muscle | 2012 |
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Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease
ZF Issa, JM Miller, DP Zipes |
Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease | 2012 |
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Detecting pore-lining regions in transmembrane protein sequences
T Nugent, DT Jones |
BMC bioinformatics | 2012 |
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1,4-dihydropyridines: the multiple personalities of a blockbuster drug family
M Cataldi, F Bruno |
Translational medicine @ UniSa | 2012 |
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Ca 2+ Channel Activators Reveal Differential L-Type Ca 2+ Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes
J Kang, XL Chen, J Ji, Q Lei, D Rampe |
The Journal of pharmacology and experimental therapeutics | 2012 |
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Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice
Sanjeewa Goonasekera, Karin Hammer, Mannix Auger-Messier, Illona Bodi, Xiongwen Chen, Hongyu Zhang, Steve Reiken, John Elrod, Robert, Nathan Correll, Allen York, Michelle Sargent, Franz Hofmann, Sven Moosmang, Andrew R. Marks, Steven Houser, Donald Bers, Jeffery Molkentin |
Journal of Clinical Investigation | 2011 |
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Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress*
B Razani, H Zhang, PC Schulze, JD Schilling, J Verbsky, IJ Lodhi, VK Topkara, C Feng, T Coleman, A Kovacs, DP Kelly, JE Saffitz, GW 2nd, CG Nichols, CF Semenkovich |
The Journal of biological chemistry | 2011 |
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The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway
C Li, X Cai, H Sun, T Bai, X Zheng, XW Zhou, X Chen, DL Gill, J Li, XD Tang |
Biochemical and Biophysical Research Communications | 2011 |
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CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart
YM Lu, J Huang, N Shioda, K Fukunaga, Y Shirasaki, XM Li, F Han |
PloS one | 2011 |
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Methods and Principles in Medicinal Chemistry
AD Kraneveld, S Braber, S Overbeek, P Kruijf, P Koelink, MJ Smit |
Chemokine Receptors as Drug Targets | 2011 |
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Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes
RY Zhang, JB Du, Y Sun, S Chen, HJ Tsai, L Yuan, L Li, CS Tang, HF Jin |
Clinical and Experimental Pharmacology and Physiology | 2011 |
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Regulation and physiological function of Nav1.5 and KCNQ1 channels
T Jespersen |
Acta Physiologica | 2011 |
|
Quantitative aspects of L-type Ca2+ currents
HC Tuckwell |
Progress in Neurobiology | 2011 |
|
Cardiomyocyte calcineurin signaling in subcellular domains: From the sarcolemma to the nucleus and beyond
J Heineke, O Ritter |
Journal of Molecular and Cellular Cardiology | 2011 |
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Influence of pH on Ca2+ current and its control of electrical and Ca2+ signaling in ventricular myocytes
N Saegusa, E Moorhouse, RD Vaughan-Jones, KW Spitzer |
The Journal of General Physiology | 2011 |
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Robust L-type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heart: Robust expression of L-type calcium current
B Rosati, Q Yan, MS Lee, SR Liou, B Ingalls, J Foell, TJ Kamp, D McKinnon |
The Journal of Physiology | 2011 |
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CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart
YM Lu, J Huang, N Shioda, K Fukunaga, Y Shirasaki, X Li, F Han, RE Means |
PloS one | 2011 |
|
Calcium handling in zebrafish ventricular myocytes
PC Zhang, A Llach, XY Sheng, L Hove-Madsen, GF Tibbits |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2011 |
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Mechanical Stretch and Cytokines
A Kamkin, I Kiseleva |
2011 | |
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Cardiac gene therapy
AH Chaanine, J Kalman, RJ Hajjar |
Seminars in Thoracic and Cardiovascular Surgery | 2010 |
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Increasing Cardiac Contractility After Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction
H Zhang, X Chen, E Gao, SM MacDonnell, W Wang, M Kolpakov, H Nakayama, X Zhang, N Jaleel, DM Harris, Y Li, M Tang, R Berretta, A Leri, J Kajstura, A Sabri, WJ Koch, JD Molkentin, SR Houser |
Circulation research | 2010 |
|
L-type Ca2+ current in ventricular cardiomyocytes
JP Benitah, JL Alvarez, AM Gómez |
Journal of Molecular and Cellular Cardiology | 2010 |
|
Paediatric Cardiology
CC Mota, VD Aiello, RH Anderson |
Paediatric Cardiology | 2010 |
|
Molecular mechanism of calcium channel regulation in the fight-or-flight response
MD Fuller, MA Emrick, M Sadilek, T Scheuer, WA Catterall |
Science signaling | 2010 |
|
Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations
A Corrias, X Jie, L Romero, MJ Bishop, M Bernabeu, E Pueyo, B Rodriguez |
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences | 2010 |
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Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells
N Babai, N Kanevsky, N Dascal, GJ Rozanski, DP Singh, N Fatma, WB Thoreson |
PloS one | 2010 |
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Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca2+ channels
G González, D Zaldívar, E Carrillo, A Hernández, M García, J Sánchez |
British Journal of Pharmacology | 2010 |
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Ubiquitylation and SUMOylation of Cardiac Ion Channels
JS Rougier, M Albesa, H Abriel |
Journal of Cardiovascular Pharmacology | 2010 |
|
Reduced L-type calcium current in ventricular myocytes from pigs with hyperdynamic septic shock*
M Stengl, F Bartak, R Sykora, J Chvojka, J Benes, A Krouzecky, I Novak, J Sviglerova, J Kuncova, M Matejovic |
Critical Care Medicine | 2010 |
|
Cross-talk between L-type Ca2+channels and mitochondria
HM Viola, LC Hool |
Clinical and Experimental Pharmacology and Physiology | 2010 |
|
Ion channels in toxicology
I Restrepo-Angulo, AD Vizcaya-Ruiz, J Camacho |
Journal of Applied Toxicology | 2010 |
|
Molecular genetics of Brugada syndrome
T Ke, X Tu, S Zhang, Y Liao, QK Wang |
Frontiers in Biology | 2010 |
|
L-type Ca2+ channels: A new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells
Y Suzuki, T Inoue, C Ra |
Molecular Immunology | 2010 |
|
Daurisoline Suppressed Early Afterdepolarizations and Inhibited L-Type Calcium Current
QN Liu, L Zhang, PL Gong, XY Yang, FD Zeng |
The American journal of Chinese medicine | 2010 |
|
NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/Salicylates
Y Suzuki, T Inoue, C Ra |
Pharmaceuticals (Basel, Switzerland) | 2010 |
|
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
Z Pedrozo, G Sánchez, N Torrealba, R Valenzuela, C Fernández, C Hidalgo, S Lavandero, P Donoso |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2010 |
|
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
|
Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies
SY Ng, CK Wong, SY Tsang |
American journal of physiology. Cell physiology | 2010 |
|
Akt regulates L-Type Calcium Channel activity by modulating Cavalpha1 protein stability
Daniele Catalucci, Deng-Hong Zhang, Jaime DeSantiago, Franck Aimond, Barbara Guillaume, Jean Chemin, Eckard Picht, Francesca Rusconi, Nancy, Dalton, Dario R. Alessi, Kirk L. Peterson, Sylvain Richard, Donald M. Bers, Joan, Heller Brown, Gianluigi Condorelli |
2009 | |
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Developmental Control of CaV1.2 L-Type Calcium Channel Splicing by Fox Proteins
ZZ Tang, S Zheng, J Nikolic, DL Black |
Molecular and cellular biology | 2009 |
|
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice
N Beetz, L Hein, J Meszaros, R Gilsbach, F Barreto, M Meissner, UC Hoppe, A Schwartz, S Herzig, J Matthes |
Cardiovascular Research | 2009 |
|
Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels
S Levy, O Beharier, Y Etzion, M Mor, L Buzaglo, L Shaltiel, LA Gheber, J Kahn, AJ Muslin, A Katz, D Gitler, A Moran |
The Journal of biological chemistry | 2009 |
|
Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the alpha(1C)TG mouse
S Wang, B Ziman, I Bodi, M Rubio, YY Zhou, K D'Souza, NH Bishopric, A Schwartz, EG Lakatta |
PloS one | 2009 |
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Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca Channels in Neonatal Rat Ventricular Cardiomyocytes
OV Yarishkin, EM Hwang, D Kim, JC Yoo, SS Kang, DR Kim, JH Shin, HJ Chung, HS Jeong, D Kang, J Han, JY Park, SG Hong |
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology | 2009 |
|
Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel alpha1C subunit in chicken cone photoreceptors
L Shi, ML Ko, GY Ko |
The Journal of biological chemistry | 2009 |
|
Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina
L Shi, K Jian, ML Ko, D Trump, GY Ko |
The Journal of biological chemistry | 2009 |
|
L-type Ca2+ channels in mast cells: Activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels
T Yoshimaru, Y Suzuki, T Inoue, C Ra |
Molecular Immunology | 2009 |
|
Cav1.2 L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption
Y Suzuki, T Yoshimaru, T Inoue, C Ra |
Molecular Immunology | 2009 |
|
Verapamil for Cluster Headache. Clinical Pharmacology and Possible Mode of Action
P Tfelt-Hansen, J Tfelt-Hansen |
Headache: The Journal of Head and Face Pain | 2009 |
|
Impact of Dihydrotestosterone on L-Type Calcium Channels in Human Ventricular Cardiomyocytes
F Er, N Gassanov, MC Brandt, N Madershahian, UC Hoppe |
Endocrine Research | 2009 |
|
Dilated Cardiomyopathy with Increased SR Ca2+ Loading Preceded by a Hypercontractile State and Diastolic Failure in the α1CTG Mouse
S Wang, B Ziman, I Bodi, M Rubio, YY Zhou, K D'Souza, NH Bishopric, A Schwartz, EG Lakatta, PH Reitsma |
PloS one | 2009 |
|
Rhythmic Expression of MicroRNA-26a Regulates the L-type Voltage-gated Calcium Channel α1C Subunit in Chicken Cone Photoreceptors
L Shi, ML Ko, GY Ko |
The Journal of biological chemistry | 2009 |
|
Ca 2+ Influx Through T- and L-Type Ca 2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes
N Jaleel, H Nakayama, X Chen, H Kubo, S MacDonnell, H Zhang, R Berretta, J Robbins, L Cribbs, JD Molkentin, SR Houser |
Circulation research | 2008 |
|
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension
K Wenzel, H Haase, G Wallukat, W Derer, S Bartel, V Homuth, F Herse, N Hubner, H Schulz, M Janczikowski, C Lindschau, C Schroeder, S Verlohren, I Morano, DN Muller, FC Luft, R Dietz, R Dechend, P Karczewski |
PloS one | 2008 |
|
Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation
X Chen, X Zhang, DM Harris, VP 3rd, RM Berretta, KB Margulies, SR Houser |
American journal of physiology. Heart and circulatory physiology | 2008 |
|
Differential Regulated Interactions of Calcium/Calmodulin-Dependent Protein Kinase II with Isoforms of Voltage-Gated Calcium Channel β Subunits
CE Grueter, SA Abiria, Y Wu, ME Anderson, RJ Colbran |
Biochemistry | 2008 |
|
Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers
S Hanafy, NJ Dagenais, WF Dryden, F Jamali |
British Journal of Pharmacology | 2008 |
|
L-type calcium channel current up-regulation by chronic stress is associated with increased alpha(1c) subunit expression in rat ventricular myocytes
Y Zhao, J Xu, J Gong, L Qian |
Cell stress & chaperones | 2008 |
|
Swimming training can affect intrinsic calcium current characteristics in rat myocardium
S Wang, JZ Ma, SS Zhu, DJ Xu, JG Zou, KJ Cao |
European Journal of Applied Physiology | 2008 |
|
The high-affinity immunoglobulin E receptor (FcɛRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcɛRIβ chain immunoreceptor tyrosine-based activation motif
Y Suzuki, T Yoshimaru, T Inoue, S Nunomura, C Ra |
Biochemical Pharmacology | 2008 |
|
Peculiarities of Ca2+-regulation of functional activity of myocardium of frog Rana temporaria
IV Shemarova, SV Kuznetsov, IN Demina, VP Nesterov |
Journal of Evolutionary Biochemistry and Physiology | 2008 |
|
Cardiac cell: a biological laser?
D Chorvat, A Chorvatova |
Biosystems | 2008 |
|
Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Cav1.2 Phosphorylation Site S1928A Mutant Mice*
T Lemke, A Welling, CJ Christel, A Blaich, D Bernhard, P Lenhardt, F Hofmann, S Moosmang |
The Journal of biological chemistry | 2008 |
|
Carbon Monoxide Inhibits L-type Ca2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species*
JL Scragg, ML Dallas, JA Wilkinson, G Varadi, C Peers |
The Journal of biological chemistry | 2008 |
|
Potential Relevance of α1-Adrenergic Receptor Autoantibodies in Refractory Hypertension
K Wenzel, H Haase, G Wallukat, W Derer, S Bartel, V Homuth, F Herse, N Hubner, H Schulz, M Janczikowski, C Lindschau, C Schroeder, S Verlohren, I Morano, DN Muller, FC Luft, R Dietz, R Dechend, P Karczewski, T Secomb |
PloS one | 2008 |
|
Carbon Monoxide Inhibits L-type Ca 2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species
JL Scragg, ML Dallas, JA Wilkinson, G Varadi, C Peers |
The Journal of biological chemistry | 2008 |
|
Retinoschisin, a New Binding Partner for L-type Voltage-gated Calcium Channels in the Retina
L Shi, K Jian, ML Ko, D Trump, GY Ko |
The Journal of biological chemistry | 2008 |
|
Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Ca v 1.2 Phosphorylation Site S1928A Mutant Mice
T Lemke, A Welling, CJ Christel, A Blaich, D Bernhard, P Lenhardt, F Hofmann, S Moosmang |
The Journal of biological chemistry | 2008 |
|
Toward Biologically Targeted Therapy of Calcium Cycling Defects in Heart Failure
Y Ikeda, M Hoshijima, KR Chien |
Physiology (Bethesda, Md.) | 2008 |
|
Reduced effects of BAY K 8644 on L-type Ca 2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation
X Chen, X Zhang, DM Harris, V Piacentino, RM Berretta, KB Margulies, SR Houser |
American journal of physiology. Heart and circulatory physiology | 2008 |
|
Protein-Protein Interactions as New Drug Targets
E Klussmann, J Scott |
2008 | |
|
A novel autoantibody in patients with primary hypertension: antibody against L-type Ca2+ channel:
Z ZHOU, J WANG, H XIAO, Z CHEN, M WANG, X CHENG, Y LIAO |
Chinese Medical Journal | 2008 |
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Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure
Hiroyuki Nakayama1, Xiongwen Chen, Christopher P. Baines, Raisa Klevitsky, Xiaoying Zhang, Hongyu Zhang, Naser Jaleel, Balvin H. L. Chua, Timothy E. Hewett, Jeffrey Robbins, Steven R. Houser, Jeffery D. Molkentin |
Journal of Clinical Investigation | 2007 |
|
Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure
R Hullin, J Matthes, S Vietinghoff, I Bodi, M Rubio, K D'Souza, IF Khan, D Rottländer, UC Hoppe, P Mohacsi, E Schmitteckert, R Gilsbach, M Bünemann, L Hein, A Schwartz, S Herzig |
PloS one | 2007 |
|
Cardiac GPCRs: GPCR signaling in healthy and failing hearts
NC Salazar, J Chen, HA Rockman |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2007 |
|
Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels
V Yarotskyy, KS Elmslie |
British Journal of Pharmacology | 2007 |
|
Heart Failure
HH Chen |
Journal of the American College of Cardiology | 2007 |
|
Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties
ZZ Tang, X Hong, J Wang, TW Soong |
Cell Calcium | 2007 |
|
The GK domain of the voltage-dependent calcium channel β subunit is essential for binding to the α subunit
T Kobayashi, Y Yamada, M Fukao, K Shiratori, M Tsutsuura, K Tanimoto, N Tohse |
Biochemical and Biophysical Research Communications | 2007 |
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Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers
HS Kim, Y Kim, MR Doddareddy, SH Seo, H Rhim, J Tae, AN Pae, H Choo, YS Cho |
Bioorganic & Medicinal Chemistry Letters | 2007 |
|
Modeling Cardiac Uptake and Negative Inotropic Response of Verapamil in Rat Heart: Effect of Amiodarone
P Sermsappasuk, O Abdelrahman, M Weiss |
Pharmaceutical Research | 2006 |
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