Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Endothelial cell–restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury
You-Yang Zhao, … , Robert H. Costa, Asrar B. Malik
You-Yang Zhao, … , Robert H. Costa, Asrar B. Malik
Published September 1, 2006
Citation Information: J Clin Invest. 2006;116(9):2333-2343. https://doi.org/10.1172/JCI27154.
View: Text | PDF
Research Article Vascular biology

Endothelial cell–restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury

  • Text
  • PDF
Abstract

Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis. However, little is known about the molecular mechanisms of endothelial barrier repair following injury. To investigate the functional role of forkhead box M1 (FoxM1) in the mechanism of endothelial repair, we generated endothelial cell–restricted FoxM1-deficient mice (FoxM1 CKO mice). These mutant mice were viable and exhibited no overt phenotype. However, in response to the inflammatory mediator LPS, FoxM1 CKO mice displayed significantly protracted increase in lung vascular permeability and markedly increased mortality. Following LPS-induced vascular injury, FoxM1 CKO lungs demonstrated impaired cell proliferation in association with sustained expression of p27Kip1 and decreased expression of cyclin B1 and Cdc25C. Endothelial cells isolated from FoxM1 CKO lungs failed to proliferate, and siRNA-mediated suppression of FoxM1 expression in human endothelial cells resulted in defective cell cycle progression. Deletion of FoxM1 in endothelial cells induced decreased expression of cyclins, Cdc2, and Cdc25C, increased p27Kip1 expression, and decreased Cdk activities. Thus, FoxM1 plays a critical role in the mechanism of the restoration of endothelial barrier function following vascular injury. These data suggest that impairment in FoxM1 activation may be an important determinant of the persistent vascular barrier leakiness and edema formation associated with inflammatory diseases.

Authors

You-Yang Zhao, Xiao-Pei Gao, Yidan D. Zhao, Muhammad K. Mirza, Randall S. Frey, Vladimir V. Kalinichenko, I-Ching Wang, Robert H. Costa, Asrar B. Malik

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 4 7 11 3 6 5 6 6 5 2 5 10 5 7 7 8 6 5 1 1 110
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (110)

Title and authors Publication Year
Pyroptosis of pulmonary fibroblasts through NLRC4 inflammasome leads to acute respiratory failure
Yan Zhang, Guoying Zhang, Brittany Dong, Ankit Pandeya, Jian Cui, Samuel Valenca, Ling Yang, Congqing Wu, Daniel Kirchhofer, Toshihiko Shiroishi, Fadi Khasawneh, Min Tao, Feng Shao, Christopher Waters, Yinan Wei, Zhenyu Li
Cell reports 2025
Endothelial FoxM1 and Dab2 promotes diabetic wound healing
Sudarshan Bhattacharjee, Jianing Gao, Yao Wei Lu, Shahram Eisa-Beygi, Hao Wu, Kathryn Li, Amy Birsner, Scott Wong, Yudong Song, John Shyy, Douglas B. Cowan, Wendong Huang, Wenyi Wei, Masanori Aikawa, Jinjun Shi, Hong Chen
JCI Insight 2025
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling
Yao L, Chen Z, Gan S, Fu C, Xie Z, Zhang H, Yang C, Fu L, Liu Y, Luo M, Kuang D, Cao J, Hu G, Li S, Yang L, Li L, Chen X, Tang H
Cell Communication and Signaling : CCS 2025
Spatially fractionated minibeam radiation delivered at clinically feasible dose rates induces transient vascular permeability
Fazzari J, Fernandez-Palomo C, Pellicioli P, Day L, Trappetti V, Lucien-Matteoni F, Kim Y, Mutter R, Park S, Grams M, Djonov V
Scientific Reports 2025
Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal transition in regenerating pig hearts
Nguyen TM, Geng X, Wei Y, Ye L, Garry DJ, Zhang J
Frontiers in Bioengineering and Biotechnology 2024
Neutrophil Extracellular Traps Upregulate p21 and Suppress Cell Cycle Progression to Impair Endothelial Regeneration after Inflammatory Lung Injury
Zhu S, Yu Y, Hong Q, Li C, Zhang H, Guo K
Journal of Clinical Medicine 2024
Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury
Osorio-Valencia S, Zhou B
Biomedicines 2024
Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury
Kutumova EO, Akberdin IR, Egorova VS, Kolesova EP, Parodi A, Pokrovsky VS, Zamyatnin, Jr AA, Kolpakov FA
Heliyon 2024
Cell Proliferation and Apoptosis—Key Players in the Lung Aging Process
Ancer-Rodríguez J, Gopar-Cuevas Y, García-Aguilar K, Chávez-Briones MD, Miranda-Maldonado I, Ancer-Arellano A, Ortega-Martínez M, Jaramillo-Rangel G
International journal of molecular sciences 2024
Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing
Bhattacharjee S, Gao J, Lu YW, Eisa-Beygi S, Wu H, Li K, Birsner AE, Wong S, Song Y, Shyy JY, Cowan DB, Wei W, Aikawa M, Shi J, Chen H
bioRxiv 2024
Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors.
Zhu X, Meng L, Xu L, Hua Y, Feng J
Lung 2024
Overexpression of FoxM1 optimizes the therapeutic effect of bone marrow mesenchymal stem cells on acute respiratory distress syndrome
Luo Y, Ge S, Chen Q, Lin S, He W, Zeng M
Stem Cell Research & Therapy 2023
Overexpression of FoxM1 Enhanced the Protective Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Lipopolysaccharide-Induced Acute Lung Injury through the Activation of Wnt/β-Catenin Signaling
Luo Y, Lin S, Mao X, Yang Y, He W, Guo M, Zeng M
Oxidative medicine and cellular longevity 2023
Endothelial cell autophagy in the context of disease development
Marzoog BA
Anatomy & cell biology 2023
FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases
Zhang Z, Li M, Sun T, Zhang Z, Liu C
Biomolecules 2023
What the BTBR/J mouse has taught us about diabetes and diabetic complications
Keller MP, Hudkins KL, Shalev A, Bhatnagar S, Kebede MA, Merrins MJ, Davis DB, Alpers CE, Kimple ME, Attie AD
iScience 2023
Dedifferentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development in Mice
Arolkar G, Kumar SK, Wang H, Gonzalez KM, Kumar S, Bishnoi B, Rios Coronado PE, Woo YJ, Red-Horse K, Das S
Arteriosclerosis, thrombosis, and vascular biology 2023
Modulation of the Host Response as a Therapeutic Strategy in Severe Lung Infections.
Latreille E, Lee WL
Viruses 2023
Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth
Rao S, Liu M, Iosef C, Knutsen C, Alvira CM
AJP Lung Cellular and Molecular Physiology 2023
Endothelial cell clonality, heterogeneity and dysfunction in pulmonary arterial hypertension.
Newcomb G, Farkas L
Frontiers in Medicine 2023
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury
Huang X, Zhang X, Machireddy N, Evans CE, Trewartha SD, Hu G, Fang Y, Mutlu GM, Wu D, Zhao YY
Science Translational Medicine 2023
Transcription factors regulating vasculogenesis and angiogenesis
Payne S, Neal A, De Val S
Developmental Dynamics 2023
Rabeprazole Promotes Vascular Repair and Resolution of Sepsis-Induced Inflammatory Lung Injury through HIF-1α
C Evans, Y Peng, M Zhu, Z Dai, X Zhang, Y Zhao
Cells 2022
Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
Zhang X, Jin H, Huang X, Chaurasiya B, Dong D, Shanley TP, Zhao YY
Cell Reports 2022
PVECs‐Derived Exosomal microRNAs Regulate PASMCs via FoxM1 Signaling in IUGR‐induced Pulmonary Hypertension
Luo X, Hang C, Zhang Z, Le K, Ying Y, Lv Y, Yan L, Huang Y, Ye L, Xu X, Zhong Y, Du L
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2022
Programming to S1PR1 + Endothelial Cells Promotes Restoration of Vascular Integrity
Z Akhter, JC Joshi, VA Ragunathrao, M Maienschein-Cline, RL Proia, AB Malik, D Mehta
Circulation research 2021
Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities
R Sanwal, K Joshi, M Ditmans, SS Tsai, WL Lee
Biomedicines 2021
FOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic Target in Ovarian Cancer
C Liu, CJ Barger, AR Karpf
Cancers 2021
Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension
D Yi, B Liu, T Wang, Q Liao, MM Zhu, YY Zhao, Z Dai
International journal of molecular sciences 2021
Functional Roles for CD26/DPP4 in Mediating Inflammatory Responses of Pulmonary Vascular Endothelial Cells.
Takahashi Y, Kawasaki T, Sato H, Hasegawa Y, Dudek SM, Ohara O, Tatsumi K, Suzuki T
Cells 2021
CD38-mediated Inhibition of Bruton’s Tyrosine Kinase in Macrophages Prevents Endotoxemic Lung Injury
Farahany J, Tsukasaki Y, Mukhopadhyay A, Mittal M, Nepal S, Tiruppathi C, Malik AB
American journal of respiratory cell and molecular biology 2021
Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis
F Lopes-Coelho, F Silva, S Gouveia-Fernandes, C Martins, N Lopes, G Domingues, C Brito, AM Almeida, SA Pereira, J Serpa
Cells 2020
Mechanisms of Endothelial Regeneration and Vascular Repair and Their Application to Regenerative Medicine
CE Evans, ML Iruela-Arispe, YY Zhao
The American Journal of Pathology 2020
Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury
S Franco, A Stranz, F Ljumani, G Urabe, M Chaudhary, D Stewart, VS Pilli, M Kelly, D Yamanouchi, KC Kent, B Liu
Heliyon 2020
Glycogen synthase kinase‐3β inhibits tubular regeneration in acute kidney injury by a FoxM1‐dependent mechanism
S Sinha, N Dwivedi, J Woodgett, S Tao, C Howard, TA Fields, A Jamadar, R Rao
The FASEB Journal 2020
Studies on the effects of bone marrow stem cells on mitochondrial function and the alleviation of ARDS
K Zhang, Y Gao, Y Deng, X Zhou, C Zhu, Z He, D Lv
Molecular and Cellular Biochemistry 2020
Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
M Liu, L Zhang, G Marsboom, A Jambusaria, S Xiong, PT Toth, EV Benevolenskaya, J Rehman, AB Malik
Nature Communications 2019
Endothelial HIF-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through FoxM1
X Huang, X Zhang, DX Zhao, J Yin, G Hu, CE Evans, YY Zhao
The American Journal of Pathology 2019
RNAi therapeutic strategies for acute respiratory distress syndrome
ML Jagrosse, DA Dean, A Rahman, BL Nilsson
Translational research : the journal of laboratory and clinical medicine 2019
Building and Regenerating the Lung Cell by Cell
JA Whitsett, TV Kalin, Y Xu, VV Kalinichenko
Physiological reviews 2019
MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression
R Huang, Z Hu, Y Cao, H Li, H Zhang, W Su, Y Xu, L Liang, ND Melgiri, L Jiang
EBioMedicine 2019
The multifaceted roles of FOXM1 in pulmonary disease
Y Li, F Wu, Q Tan, M Guo, P Ma, X Wang, S Zhang, J Xu, P Luo, Y Jin
Cell Communication and Signaling 2019
Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension
Z Dai, MM Zhu, Y Peng, H Jin, N Machireddy, Z Qian, X Zhang, YY Zhao
American journal of respiratory and critical care medicine 2018
Roles of heat shock factor 1 beyond the heat shock response
J Barna, P Csermely, T Vellai
Cellular and Molecular Life Sciences 2018
Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways
K Sun, R Huang, L Yan, DT Li, YY Liu, XH Wei, YC Cui, CS Pan, JY Fan, X Wang, JY Han
Frontiers in physiology 2018
Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?
JM Real, LR Ferreira, GH Esteves, FC Koyama, MV Dias, JE Bezerra-Neto, E Cunha-Neto, FR Machado, R Salomão, LC Azevedo
Critical Care 2018
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury
J Lv, J Zeng, F Guo, Y Li, M Xu, Y Cheng, L Zhang, S Cai, Y Chen, Y Zheng, G Hu
Respiratory Research 2018
Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
T Izumi, J Imai, J Yamamoto, Y Kawana, A Endo, H Sugawara, M Kohata, Y Asai, K Takahashi, S Kodama, K Kaneko, J Gao, K Uno, S Sawada, VV Kalinichenko, Y Ishigaki, T Yamada, H Katagiri
Nature Communications 2018
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism
J Yamamoto, J Imai, T Izumi, H Takahashi, Y Kawana, K Takahashi, S Kodama, K Kaneko, J Gao, K Uno, S Sawada, T Asano, VV Kalinichenko, EA Susaki, M Kanzaki, HR Ueda, Y Ishigaki, T Yamada, H Katagiri
Nature Communications 2017
STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry
P Yazbeck, M Tauseef, K Kruse, MR Amin, R Sheikh, S Feske, Y Komarova, D Mehta
Scientific Reports 2017
Lipopolysaccharide-induced endotoxemia in corn oil-preloaded mice causes an extended course of lung injury and repair and pulmonary fibrosis: A translational mouse model of acute respiratory distress syndrome
C Wu, CE Evans, Z Dai, X Huang, X Zhang, H Jin, G Hu, Y Song, YY Zhao, X Su
PloS one 2017
Impact of thrombosis on pulmonary endothelial injury and repair following sepsis
CE Evans, YY Zhao
American journal of physiology. Lung cellular and molecular physiology 2017
XOR inhibition with febuxostat accelerates pulmonary endothelial barrier recovery and improves survival in lipopolysaccharide‐induced murine sepsis
M Damarla, LF Johnston, G Liu, L Gao, L Wang, L Varela, TM Kolb, BS Kim, RL Damico, PM Hassoun
Physiological Reports 2017
Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular InjuryCLINICAL PERSPECTIVE
X Huang, Z Dai, L Cai, K Sun, J Cho, KH Albertine, AB Malik, DE Schraufnagel, YY Zhao
Circulation 2016
MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular InjurySignificance
C Rajput, M Tauseef, M Farazuddin, P Yazbeck, MR Amin, VA BR, T Sharma, D Mehta
Arteriosclerosis, thrombosis, and vascular biology 2016
Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling
W Zhang, Z Jiang, B He, X Liu
Inflammation 2015
Foxm1 Regulates Resolution of Hyperoxic Lung Injury in Newborns
H Xia, X Ren, CS Bolte, V Ustiyan, Y Zhang, TA Shah, TV Kalin, JA Whitsett, VV Kalinichenko
American journal of respiratory cell and molecular biology 2015
Activation of Type II Cells into Regenerative Stem Cell Antigen-1 + Cells during Alveolar Repair
Y Liu, VS Kumar, W Zhang, J Rehman, AB Malik
American journal of respiratory cell and molecular biology 2015
Resident Endothelial Cells and Endothelial Progenitor Cells Restore Endothelial Barrier Function After Inflammatory Lung InjurySignificance
SZ Mao, X Ye, G Liu, D Song, SF Liu
Arteriosclerosis, thrombosis, and vascular biology 2015
Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell
Z Merhi, AJ Polotsky, AP Bradford, E Buyuk, J Chosich, T Phang, S Jindal, N Santoro
Reproductive sciences (Thousand Oaks, Calif.) 2015
Human CD34+ progenitor cells freshly isolated from umbilical cord blood attenuate inflammatory lung injury following LPS challenge
X Huang, K Sun, YD Zhao, SM Vogel, Y Song, N Mahmud, YY Zhao
PloS one 2014
Loss of caveolin-1 and adiponectin induces severe inflammatory lung injury following LPS challenge through excessive oxidative/nitrative stress
L Cai, F Yi, Z Dai, X Huang, YD Zhao, MK Mirza, J Xu, SM Vogel, YY Zhao
American journal of physiology. Lung cellular and molecular physiology 2014
The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation
C Tiruppathi, D Soni, DM Wang, J Xue, V Singh, PB Thippegowda, BP Cheppudira, RK Mishra, A Debroy, Z Qian, K Bachmaier, YY Zhao, JW Christman, SM Vogel, A Ma, AB Malik
Nature Immunology 2014
Combinatorial Therapy with Acetylation and Methylation Modifiers Attenuates Lung Vascular Hyperpermeability in Endotoxemia-Induced Mouse Inflammatory Lung Injury
J Thangavel, AB Malik, HK Elias, S Rajasingh, AD Simpson, PK Sundivakkam, SM Vogel, YT Xuan, B Dawn, R Johnson
The American Journal of Pathology 2014
Endothelial progenitor cells and vascular repair:
M Zhang, AB Malik, J Rehman
Current Opinion in Hematology 2014
Endothelial FoxM1 Mediates Bone Marrow Progenitor Cell-Induced Vascular Repair and Resolution of Inflammation following Inflammatory Lung Injury: Endothelial FoxM1 in BMPC-Induced Vascular Repair
YD Zhao, X Huang, F Yi, Z Dai, Z Qian, C Tiruppathi, K Tran, YY Zhao
Stem Cells 2014
NF-κB-to-AP-1 switch: a mechanism regulating transition from endothelial barrier injury to repair in endotoxemic mice
G Liu, X Ye, EJ Miller, SF Liu
Scientific Reports 2014
Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into mice with LPS-induced acute lung injury
H Chen, S Wu, R Lu, Y Zhang, Y Zheng, J Sun
PloS one 2014
PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice
K Kapoor, E Singla, B Sahu, AS Naura
Molecular and Cellular Biochemistry 2014
Activated FoxM1 Attenuates Streptozotocin-Mediated β-Cell Death
ML Golson, MF Maulis, JC Dunn, G Poffenberger, J Schug, KH Kaestner, MA Gannon
Molecular Endocrinology 2014
A critical role for Lyn kinase in strengthening endothelial integrity and barrier function
J Han, G Zhang, EJ Welch, Y Liang, J Fu, SM Vogel, CA Lowell, X Du, DA Cheresh, AB Malik, Z Li
Blood 2013
Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis
Y Cai, D Balli, V Ustiyan, L Fulford, A Hiller, V Misetic, Y Zhang, AM Paluch, SE Waltz, S Kasper, TV Kalin
The Journal of biological chemistry 2013
PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response
G Wang, X Huang, Y Li, K Guo, P Ning, Y Zhang
PloS one 2013
Decreased Expression of Surfactant Protein Genes Is Associated with an Increased Expression of Forkhead Box M1 Gene in the Fetal Lung Tissues of Premature Rabbits
WH Hahn, JY Chang, KS Lee, CW Bae
Yonsei Medical Journal 2013
Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation
DR Winden, NT Ferguson, BR Bukey, AJ Geyer, AJ Wright, ZR Jergensen, AB Robinson, JA Stogsdill, PR Reynolds
Respiratory Research 2013
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation
X Ren, TA Shah, V Ustiyan, Y Zhang, J Shinn, G Chen, JA Whitsett, TV Kalin, VV Kalinichenko
Molecular and cellular biology 2012
Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling
C Bolte, Y Zhang, A York, TV Kalin, JE Schultz, JD Molkentin, VV Kalinichenko
PloS one 2012
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation
M Tauseef, N Knezevic, KR Chava, M Smith, S Sukriti, N Gianaris, AG Obukhov, SM Vogel, DE Schraufnagel, A Dietrich, L Birnbaumer, AB Malik, D Mehta
Journal of Experimental Medicine 2012
Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration
BJ Walters, J Zuo
Hearing Research 2012
Forkhead box M1 is regulated by heat shock factor 1 and promotes glioma cells survival under heat shock stress
B Dai, A Gong, Z Jing, KD Aldape, SH Kang, R Sawaya, S Huang
The Journal of biological chemistry 2012
Transgenic expression of FoxM1 promotes endothelial repair following lung injury induced by polymicrobial sepsis in mice
X Huang, YY Zhao
PloS one 2012
FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury
L Zhang, T Li, D Yu, BM Forman, W Huang
Molecular Endocrinology 2012
FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa
Y Liu, RT Sadikot, GR Adami, VV Kalinichenko, S Pendyala, V Natarajan, Y Zhao, AB Malik
Journal of Experimental Medicine 2011
Multiple faces of FoxM1 transcription factor: Lessons from transgenic mouse models
TV Kalin, V Ustiyan, VV Kalinichenko
Cell cycle (Georgetown, Tex.) 2011
Hypoxia-induced pulmonary arterial smooth muscle cell proliferation is controlled by forkhead box M1
A Raghavan, G Zhou, Q Zhou, JC Ibe, R Ramchandran, Q Yang, H Racherla, P Raychaudhuri, JU Raj
American journal of respiratory cell and molecular biology 2011
Expression of foxm1 transcription factor in cardiomyocytes is required for myocardial development
C Bolte, Y Zhang, IC Wang, TV Kalin, JD Molkentin, VV Kalinichenko
PloS one 2011
Cytoplasmic Forkhead Box M1 (FoxM1) in Esophageal Squamous Cell Carcinoma Significantly Correlates with Pathological Disease Stage
MK Hui, KW Chan, JM Luk, NP Lee, Y Chung, LC Cheung, G Srivastava, SW Tsao, JC Tang, S Law
World Journal of Surgery 2011
Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation
D Balli, X Ren, FS Chou, E Cross, Y Zhang, VV Kalinichenko, TV Kalin
Oncogene 2011
Endothelial Cell–Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis
D Balli, Y Zhang, J Snyder, VV Kalinichenko, TV Kalin
Cancer research 2011
Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair
X Ren, Y Zhang, J Snyder, ER Cross, TA Shah, TV Kalin, VV Kalinichenko
Molecular and cellular biology 2010
Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation
MK Mirza, J Yuan, XP Gao, S Garrean, V Brovkovych, AB Malik, C Tiruppathi, YY Zhao
The American Journal of Pathology 2010
FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression
MK Mirza, Y Sun, YD Zhao, HH Potula, RS Frey, SM Vogel, AB Malik, YY Zhao
Journal of Experimental Medicine 2010
FoxM1, a forkhead transcription factor is a master cell cycle regulator for mouse mature T cells but not double positive thymocytes
L Xue, L Chiang, B He, YY Zhao, A Winoto
PloS one 2010
Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway
Y Yang, Q Li, Z Deng, Z Zhang, J Xu, G Qian, G Wang
Molecular Biology Reports 2010
Diphtheria Toxin Mutant CRM197-Mediated Transcytosis across Blood–Brain Barrier In Vitro
P Wang, Y Xue, X Shang, Y Liu
Cellular and Molecular Neurobiology 2010
A new target for proteasome inhibitors: FoxM1
AL Gartel
Expert Opinion on Investigational Drugs 2010
FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation
DB Davis, JA Lavine, JI Suhonen, KA Krautkramer, ME Rabaglia, JM Sperger, LA Fernandez, BS Yandell, MP Keller, IM Wang, EE Schadt, AD Attie
Molecular Endocrinology 2010
Persistent eNOS Activation Secondary to Caveolin-1 Deficiency Induces Pulmonary Hypertension through Protein Kinase G Nitration
You-Yang Zhao, Yidan D. Zhao*, Muhammad K. Mirza*, Julia H. Huang, Hari-Hara S.K. Potula, Steven M. Vogel, Viktor Brovkovych, Jason X-J Yuan, John Wharton, and Asrar B. Malik
Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus
V Ustiyan, IC Wang, X Ren, Y Zhang, J Snyder, Y Xu, SE Wert, JL Lessard, TV Kalin, VV Kalinichenko
Developmental Biology 2009
Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice
KK Wary, SM Vogel, S Garrean, YD Zhao, AB Malik
Stem Cells 2009
FoxM1, a critical regulator of oxidative stress during oncogenesis
HJ Park, JR Carr, Z Wang, V Nogueira, N Hay, AL Tyner, LF Lau, RH Costa, P Raychaudhuri
The EMBO Journal 2009
The FOX transcription factors regulate vascular pathology, diabetes and Tregs.
Yang XF, Fang P, Meng S, Jan M, Xiong X, Yin Y, Wang H
Frontiers in bioscience (Scholar edition) 2009
Forkhead transcription factors and cardiovascular biology
KN Papanicolaou, Y Izumiya, K Walsh
Circulation research 2008
Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation
Z Lu, J Hardt, JJ Kim
Molecular Human Reproduction 2008
Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis
F Feo, M Frau, RM Pascale
World journal of gastroenterology : WJG 2008
Endothelial pathomechanisms in acute lung injury
NA Maniatis, A Kotanidou, JD Catravas, SE Orfanos
Vascular Pharmacology 2008
Pulmonary Mastocytosis and Enhanced Lung Inflammation in Mice Heterozygous Null for the Foxf1 Gene
TV Kalin, L Meliton, AY Meliton, X Zhu, JA Whitsett, VV Kalinichenko
American journal of respiratory cell and molecular biology 2008
Pulmonary microvascular endothelial cells form a tighter monolayer when grown in chronic hypoxia
V Solodushko, JC Parker, B Fouty
American journal of respiratory cell and molecular biology 2007
Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury
T Minamino, I Komuro
Journal of Clinical Investigation 2006

← Previous 1 2 3 4 5 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts