Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets
Pier Paolo Piccaluga, … , Riccardo Dalla Favera, Stefano A. Pileri
Pier Paolo Piccaluga, … , Riccardo Dalla Favera, Stefano A. Pileri
Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):823-834. https://doi.org/10.1172/JCI26833.
View: Text | PDF
Research Article Oncology Article has an altmetric score of 12

Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets

  • Text
  • PDF
Abstract

Peripheral T cell lymphoma, unspecified (PTCL/U), the most common form of PTCL, displays heterogeneous morphology and phenotype, poor response to treatment, and poor prognosis. We demonstrate that PTCL/U shows a gene expression profile clearly distinct from that of normal T cells. Comparison with the profiles of purified T cell subpopulations (CD4+, CD8+, resting [HLA-DR–], and activated [HLA-DR+]) reveals that PTCLs/U are most closely related to activated peripheral T lymphocytes, either CD4+ or CD8+. Interestingly, the global gene expression profile cannot be surrogated by routine CD4/CD8 immunohistochemistry. When compared with normal T cells, PTCLs/U display deregulation of functional programs often involved in tumorigenesis (e.g., apoptosis, proliferation, cell adhesion, and matrix remodeling). Products of deregulated genes can be detected in PTCLs/U by immunohistochemistry with an ectopic, paraphysiologic, or stromal location. PTCLs/U aberrantly express, among others, PDGFRα, a tyrosine-kinase receptor, whose deregulation is often related to a malignant phenotype. Notably, both phosphorylation of PDGFRα and sensitivity of cultured PTCL cells to imatinib (as well as to an inhibitor of histone deacetylase) were found. These results, which might be extended to other more rare PTCL categories, provide insight into tumor pathogenesis and clinical management of PTCL/U.

Authors

Pier Paolo Piccaluga, Claudio Agostinelli, Andrea Califano, Maura Rossi, Katia Basso, Simonetta Zupo, Philip Went, Ulf Klein, Pier Luigi Zinzani, Michele Baccarani, Riccardo Dalla Favera, Stefano A. Pileri

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 4 6 4 10 13 7 7 11 13 11 13 6 7 6 9 6 2 135
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (135)

Title and authors Publication Year
The gene expression profile and cell of origin of canine peripheral T-cell lymphoma
Owens E, Harris L, Harris A, Yoshimoto J, Burnett R, Avery A
BMC Cancer 2024
KMT2D regulates activation, localization, and integrin expression by T-cells
Potter SJ, Zhang L, Kotliar M, Wu Y, Schafer C, Stefan K, Boukas L, Qu\u2019d D, Bodamer O, Simpson BN, Barski A, Lindsley AW, Bjornsson HT
Frontiers in immunology 2024
Histone Deacetylase Inhibitors for Peripheral T-Cell Lymphomas
Irimia R, Piccaluga PP
Cancers 2024
New insights into the biology of T-cell lymphomas.
Iqbal J, Inghirami G, Chan WC
Blood 2024
Tyrosine kinases in nodal peripheral T-cell lymphomas
Piccaluga PP, Cascianelli C, Inghirami G
Frontiers in Oncology 2023
PTCL, NOS: An update on classification, risk-stratification, and treatment
Weiss J, Reneau J, Wilcox RA
Frontiers in Oncology 2023
Histopathological Evaluation of Angiogenic Markers in Non-Hodgkin's Lymphoma
Singh P, Tahlan A, Mohan H, Singh R
Journal of laboratory physicians 2023
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
Zi Z, Du S, Zhang L, Wang Y, Ding L, Zhang C, Wang H, Pawlicki J, Cai Y, Yao Y, Zhou F, Tong Y, Riley JL, Cai Q, Ma X, Wei F
Blood Advances 2023
Emerging Insights into Liver X Receptor α in the Tumorigenesis and Therapeutics of Human Cancers.
Han N, Yuan M, Yan L, Tang H
Biomolecules 2023
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence
Wu G, Yoshida N, Liu J, Zhang X, Xiong Y, Heavican-Foral TB, Mandato E, Liu H, Nelson GM, Yang L, Chen R, Donovan KA, Jones MK, Roshal M, Zhang Y, Xu R, Nirmal AJ, Jain S, Leahy C, Jones KL, Stevenson KE, Galasso N, Ganesan N, Chang T, Wu WC, Louissaint A, Debaize L, Yoon H, Cin PD, Chan WC, Sui SJ, Ng SY, Feldman AL, Horwitz SM, Adelman K, Fischer ES, Chen CW, Weinstock DM, Brown M
Science Translational Medicine 2023
The Correlation of HK2 Gene Expression with the Occurrence, Immune Cell Infiltration, and Prognosis of Renal Cell Carcinoma
Liu C, Li H, Huang H, Zheng P, Li Z
Disease Markers 2022
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso I, Zujo L, Wiest I, Kodajova P, Timelthaler G, Edtmayer S, Zrimšek M, Kollmann S, Giordano C, Kothmayer M, Neubauer HA, Dey S, Schlederer M, Schmalzbauer BS, Limberger T, Probst C, Pusch O, Högler S, Tangermann S, Merkel O, Schiefer AI, Kornauth C, Prutsch N, Zimmerman M, Abraham B, Anagnostopoulos J, Quintanilla-Martinez L, Mathas S, Wolf P, Stoiber D, Staber PB, Egger G, Klapper W, Woessmann W, Look TA, Gunning P, Turner SD, Moriggl R, Lagger S, Kenner L
Molecular Cancer 2022
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS
Herek TA, Bouska A, Lone W, Sharma S, Amador C, Heavican TB, Li Y, Wei Q, Jochum D, Greiner TC, Smith L, Pileri S, Feldman AL, Rosenwald A, Ott G, Lim ST, Ong CK, Song J, Jaffe ES, Wang GG, Staudt L, Rimsza LM, Vose J, d\u2019Amore F, Weisenburger DD, Chan WC, Iqbal J
Blood 2022
Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas.
Chiba M, Shimono J, Ishio T, Takei N, Kasahara K, Ogasawara R, Ara T, Goto H, Izumiyama K, Otsuguro S, Perera LP, Hasegawa H, Maeda M, Hashino S, Maenaka K, Teshima T, Waldmann TA, Yang Y, Nakagawa M
Blood 2022
CCR7 in Blood Cancers – Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target
C Cuesta-Mateos, F Terrón, M Herling
Frontiers in Oncology 2021
Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma
B Belmonte, V Cancila, A Gulino, M Navari, W Arancio, P Macor, A Balduit, S Capolla, G Morello, D Vacca, I Ferrara, G Bertolazzi, C Balistreri, P Amico, F Ferrante, A Maiorana, T Salviato, P Piccaluga, A Mangogna
Cancers 2021
Comprehensive Analysis of Hexokinase 2 Immune Infiltrates and m6A Related Genes in Human Esophageal Carcinoma
XS Liu, JM Liu, YJ Chen, FY Li, RM Wu, F Tan, DB Zeng, W Li, H Zhou, Y Gao, ZJ Pei
Frontiers in Cell and Developmental Biology 2021
Peripheral T-Cell Lymphoma, Not Otherwise Specified: Clinical Manifestations, Diagnosis, and Future Treatment
SA Pileri, V Tabanelli, S Fiori, A Calleri, F Melle, G Motta, D Lorenzini, C Tarella, E Derenzini
Cancers 2021
Diagnostic and prognostic value of secreted protein acidic and rich in cysteine in the diffuse large B-cell lymphoma
PJ Pan, JX Liu
World journal of clinical cases 2021
Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma
I Bagaloni, A Visani, S Biagiotti, A Ruzzo, M Navari, M Etebari, L Mundo, M Granai, S Lazzi, A Isidori, F Loscocco, J Li, L Leoncini, G Visani, M Magnani, PP Piccaluga
Frontiers in Oncology 2021
Molecular understanding of peripheral T-cell lymphomas, not otherwise specified (PTCL, NOS): A complex disease category
M Sakata-Yanagimoto, K Fukumoto, K Karube, S Chiba
Journal of Clinical and Experimental Hematopathology 2021
ChoK-Full of Potential: Choline Kinase in B Cell and T Cell Malignancies.
Gokhale S, Xie P
Pharmaceutics 2021
Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers
Rodríguez M, Alonso-Alonso R, Tomás-Roca L, Rodríguez-Pinilla SM, Manso-Alonso R, Cereceda L, Borregón J, Villaescusa T, Córdoba R, Sánchez-Beato M, Fernández-Miranda I, Betancor I, Bárcena C, García JF, Mollejo M, García-Cosio M, Martin-Acosta P, Climent F, Caballero D, de la Fuente L, Mínguez P, Kessler L, Scholz C, Gualberto A, Mondéjar R, Piris MA
Blood Advances 2021
Programmed Cell Death Protein 1/Programmed Cell Death Ligand-1 Axis activates Intracellular ERK Signaling in Tumor Cells to Mediate Poor Prognosis in T-cell Lymphoma.
Li Y, Fei Y, Liu L, Song Z, Meng X, Qiu L, Li L, Qian Z, Zhou S, Ren X, Bi C, Meng B, Zhang H, Wang X, Fu K
Journal of Cancer 2021
The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL)
S Nagel, C Pommerenke, RA MacLeod, C Meyer, M Kaufmann, HG Drexler
Oncotarget 2020
Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
M Bellone, A Brevi, S Huber
Microbiology and molecular biology reviews : MMBR 2020
Identification of Hub Genes and Key Pathways Associated with Peripheral T-cell Lymphoma
H Gao, M Wang, S Li, J Niu, J Xue, J Li, X Li
2020
Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity
P Das, JH Taube
Cancers 2020
Genomics of Peripheral T-Cell Lymphoma and Its Implications for Personalized Medicine
Y Zhang, D Lee, T Brimer, M Hussaini, L Sokol
Frontiers in Oncology 2020
FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells
H Lu, M Yin, L Wang, J Cheng, W Cheng, H An, T Zhang
Cancer biology & therapy 2020
SHCBP1 promotes tumor cell proliferation, migration, and invasion, and is associated with poor prostate cancer prognosis
N Xu, YP Wu, HB Yin, SH Chen, XD Li, XY Xue, X Gou
Journal of Cancer Research and Clinical Oncology 2020
Multiple mutations at exon 2 of RHOA detected in plasma from patients with peripheral T-cell lymphoma
B Ottolini, N Nawaz, CS Trethewey, S Mamand, RL Allchin, R Dillon, PA Fields, MJ Ahearne, SD Wagner
Blood Advances 2020
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation
GJ Lee, Y Jun, HY Yoo, YK Jeon, D Lee, S Lee, J Kim
OncoImmunology 2020
Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma
R Alonso-Alonso, R Mondéjar, N Martínez, N García-Diaz, C Pérez, D Merino, M Rodríguez, A Esteve-Codina, B Fuste, M Gut, F Burrows, C Scholz, JP Vaqué, A Gualberto, MÁ Piris
Scientific Reports 2020
IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
Prokoph N, Probst NA, Lee LC, Monahan JM, Matthews JD, Liang HC, Bahnsen K, Montes-Mojarro IA, Karaca-Atabay E, Sharma GG, Malik V, Larose H, Forde SD, Ducray SP, Lobello C, Wang Q, Luan SL, Pospíšilová Š, Gambacorti-Passerini C, Burke GAA, Pervez S, Attarbaschi A, Janíková A, Pacquement H, Landman-Parker J, Lambilliotte A, Schleiermacher G, Klapper W, Jauch R, Woessmann W, Vassal G, Kenner L, Merkel O, Mologni L, Chiarle R, Brugières L, Geoerger B, Barbieri I, Turner SD
Blood 2020
Peripheral T-cell lymphoma diagnosis: building a molecular tool.
Piris MA
Haematologica 2020
Systematic Analysis of Spleen Tyrosine Kinase Expression and its Clinical Outcomes in Various Cancers
Alwithenani AI, Althubiti MA
2020
Interleukin-2–inducible T-cell kinase inhibitors modify functional polarization of human peripheral T-cell lymphoma cells
S Mamand, M Carr, RL Allchin, MJ Ahearne, SD Wagner
Blood Advances 2019
Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer
S Saha, SM Islam, M Abdullah-AL-Wadud, S Islam, F Ali, K Park
Journal of Clinical Medicine 2019
Integration of transcriptional and mutational data simplifies the stratification of peripheral T‐cell lymphoma
F Maura, L Agnelli, D Leongamornlert, N Bolli, WC Chan, A Dodero, C Carniti, TB Heavican, A Pellegrinelli, G Pruneri, A Butler, SG Bhosle, A Chiappella, AD Rocco, PL Zinzani, F Zaja, R Piva, G Inghirami, W Wang, T Palomero, J Iqbal, A Neri, PJ Campbell, P Corradini
American Journal of Hematology 2019
Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma
RL Allchin, ME Kelly, S Mamand, AG Doran, T Keane, MJ Ahearne, SD Wagner, S Stepkowski
PloS one 2019

TLR4 expression correlated with PD-L1 expression indicates a poor prognosis in patients with peripheral T-cell lymphomas


S Zhao, M Sun, H Meng, H Ji, Y Liu, M Zhang, H Li, P Li, Y Zhang, Q Zhang
Cancer management and research 2019
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets
M Etebari, M Navari, C Agostinelli, A Visani, C Peron, J Iqbal, G Inghirami, PP Piccaluga
Frontiers in Genetics 2019
Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
PP Piccaluga, M Navari, A Visani, F Rigotti, C Agostinelli, S Righi, E Diani, M Ligozzi, M Carelli, C Ponti, I Bon, D Zipeto, S Landolfo, D Gibellini
Heliyon 2019
Casein kinase 1α: biological mechanisms and theranostic potential
S Jiang, M Zhang, J Sun, X Yang
Cell Communication and Signaling 2018
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma
N Schleussner, O Merkel, M Costanza, HC Liang, F Hummel, C Romagnani, P Durek, I Anagnostopoulos, M Hummel, K Jöhrens, A Niedobitek, PR Griffin, R Piva, HL Sczakiel, W Woessmann, C Damm-Welk, C Hinze, D Stoiber, B Gillissen, SD Turner, E Kaergel, L von Hoff, M Grau, G Lenz, B Dörken, C Scheidereit, L Kenner, M Janz, S Mathas
Leukemia 2018
Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy
G Gritti, A Gianatti, F Petronzelli, RD Santis, C Pavoni, RL Rossi, L Cattaneo, LG Spagnoli, S Ferrari, A Rossi, AM Barbui, A Rambaldi
Oncotarget 2018
Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma
S Mamand, RL Allchin, MJ Ahearne, SD Wagner
Scientific Reports 2018
Novel Immunotherapies for T Cell Lymphoma and Leukemia
P Ghione, AJ Moskowitz, NE Paola, SM Horwitz, M Ruella
Current Hematologic Malignancy Reports 2018
CDK5 Functions as a Tumor Promoter in Human Lung Cancer
J Zeng, S Xie, Y Liu, C Shen, X Song, GL Zhou, C Wang
Journal of Cancer 2018
Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma.
Umakanthan JM, Iqbal J, Batlevi CL, Bouska A, Smith LM, Shostrom V, Nutsch H, William BM, Gregory Bociek R, Lunning M, Bierman P, Younes A, Armitage JO, Vose JM
British Journal of Haematology 2018
Confident gene activity prediction based on single histone modification H2BK5ac in human cell lines
F Chitsazian, M Sadeghi, E Elahi
BMC bioinformatics 2017
Mesenchymal stromal cells (MSCs) induce ex vivo proliferation and erythroid commitment of cord blood haematopoietic stem cells (CB-CD34+ cells)
S Perucca, AD Palma, PP Piccaluga, C Gemelli, E Zoratti, G Bassi, E Giacopuzzi, A Lojacono, G Borsani, E Tagliafico, MT Scupoli, S Bernardi, C Zanaglio, F Cattina, V Cancelli, M Malagola, M Krampera, M Marini, C Almici, S Ferrari, D Russo, I Kerkis
PloS one 2017
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma
Y Gu, J Zhang, X Ma, B Kim, H Wang, J Li, Y Pan, Y Xu, L Ding, L Yang, C Guo, X Wu, J Wu, K Wu, X Gan, G Li, L Li, SJ Forman, WC Chan, R Xu, W Huang
Cancer Cell 2017
SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis
C Peng, H Zhao, Y Song, W Chen, X Wang, X Liu, C Zhang, J Zhao, J Li, G Cheng, D Wu, C Gao, X Wang
Journal of Experimental & Clinical Cancer Research 2017
The heterogeneous landscape of ALK negative ALCL
E Mereu, E Pellegrino, I Scarfò, G Inghirami, R Piva
Oncotarget 2017
A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance
LY Dimberg, CG Towers, K Behbakht, TJ Hotz, J Kim, S Fosmire, CC Porter, AC Tan, A Thorburn, HL Ford
Molecular cancer research : MCR 2017
Voltage-gated calcium channels: Novel targets for cancer therapy
N Phan, CY Wang, CF Chen, Z Sun, MD Lai, YC Lin
Oncology Letters 2017
Systematic analysis of gene expression alterations and clinical outcomes of adenylate cyclase-associated protein in cancer
S Xie, C Shen, M Tan, M Li, X Song, C Wang
Oncotarget 2017
Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3)
S Ehrentraut, S Nagel, C Pommerenke, WG Dirks, H Quentmeier, M Kaufmann, C Meyer, M Zaborski, R Geffers, H Fujiwara, HG Drexler, RA MacLeod
Haematologica 2017
Cancer-type dependent expression of CK2 transcripts
MM Chua, M Lee, I Dominguez, IV Lebedeva
PloS one 2017
Nicotinamide N -Methyltransferase in Health and Cancer
D Ramsden, R Waring, D Barlow, R Parsons
International journal of tryptophan research : IJTR 2017
Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms
A Papoudou-Bai, E Hatzimichael, A Barbouti, P Kanavaros
Clinical and Experimental Medicine 2016
The Comparative Diagnostic Features of Canine and Human Lymphoma
D Seelig, A Avery, E Ehrhart, M Linden
Veterinary Sciences 2016
Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance
S Spinner, G Crispatzu, JH Yi, E Munkhbaatar, P Mayer, U Höckendorf, N Müller, Z Li, T Schader, H Bendz, S Hartmann, M Yabal, K Pechloff, M Heikenwalder, GL Kelly, A Strasser, C Peschel, ML Hansmann, J Ruland, U Keller, S Newrzela, M Herling, PJ Jost
Leukemia 2016
Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion
NP Chen, B Uddin, R Voit, E Schiebel
Proceedings of the National Academy of Sciences 2016
The curious origins of angioimmunoblastic T-cell lymphoma:
JR Cortés, T Palomero
Current Opinion in Hematology 2016
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value
E Viziteu, A Kassambara, P Pasero, B Klein, J Moreaux
Biomarker Research 2016
Cutaneous CD8+ Cytotoxic T-Cell Lymphoma Infiltrates: Clinicopathological Correlation and Outcome of 35 Cases
M Wobser, T Reinartz, S Roth, M Goebeler, A Rosenwald, E Geissinger
Oncology and Therapy 2016
Impact of intracellular ion channels on cancer development and progression
R Peruzzo, L Biasutto, I Szabò, L Leanza
European Biophysics Journal 2016
Challenging perspectives on the cellular origins of lymphoma
TI Malcolm, DJ Hodson, EA Macintyre, SD Turner
Open Biology 2016
T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment
C Casulo, O OConnor, A Shustov, M Fanale, JW Friedberg, JP Leonard, BS Kahl, RF Little, L Pinter-Brown, R Advani, S Horwitz
JNCI Journal of the National Cancer Institute 2016
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins
H Andel, Z Ren, I Koopmans, SP Joosten, KA Kocemba, W Lau, MJ Kersten, AM de Bruin, JE Guikema, H Clevers, M Spaargaren, ST Pals
Proceedings of the National Academy of Sciences 2016
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients
CY Wang, P Shahi, JT Huang, NN Phan, Z Sun, YC Lin, MD Lai, Z Werb
Molecular and Clinical Oncology 2016
Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma
C Peng, H Zhao, W Chen, Y Song, X Wang, J Li, Y Qiao, D Wu, S Ma, X Wang, C Gao
Oncotarget 2016
Conserved Molecular Underpinnings and Characterization of a Role for Caveolin-1 in the Tumor Microenvironment of Mature T-Cell Lymphomas
TA Herek, TD Shew, HN Spurgin, CE Cutucache, IR Nabi
PloS one 2015
The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes
M Fang, ML Pak, L Chamberlain, W Xing, H Yu, MR Green
Cell Reports 2015
IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
PP Piccaluga, C Agostinelli, F Fuligni, S Righi, C Tripodo, MC Re, A Clò, A Miserocchi, S Morini, M Gariglio, GG Ferri, A Rinaldi-Ceroni, O Piccin, MD Andrea, SA Pileri, S Landolfo, D Gibellini
Journal of Immunology Research 2015
To Each Its Own: Linking the Biology and Epidemiology of NHL Subtypes
JL Koff, D Chihara, A Phan, LJ Nastoupil, JN Williams, CR Flowers
Current Hematologic Malignancy Reports 2015
The role of CCN family genes in haematological malignancies
JE Wells, M Howlett, LC Cheung, UR Kees
Journal of Cell Communication and Signaling 2015
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100
Z Zhang, Y Wang, C Li, Z Shi, Q Hao, W Wang, X Song, Y Zhao, S Jiao, Z Zhou
The Journal of biological chemistry 2015
The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19Arf pathways to suppress innate variant T FH cell development, thymocyte expansion, and lymphomagenesis
M Miyazaki, K Miyazaki, S Chen, V Chandra, K Wagatsuma, Y Agata, HR Rodewald, R Saito, AN Chang, N Varki, H Kawamoto, C Murre
Genes & development 2015
The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer
Z Siprashvili, DE Webster, D Johnston, RM Shenoy, AJ Ungewickell, A Bhaduri, R Flockhart, BJ Zarnegar, Y Che, F Meschi, JD Puglisi, PA Khavari
Nature Genetics 2015
SNPs Array Karyotyping in Non-Hodgkin Lymphoma
M Etebari, M Navari, P Piccaluga
Microarrays 2015
STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas
N Yoshida, S Tsuzuki, K Karube, T Takahara, M Suguro, H Miyoshi, M Nishikori, M Shimoyama, K Tsukasaki, K Ohshima, M Seto
Cancer Science 2015
ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion.
Wu J, Chen XH, Wang XQ, Yu Y, Ren JM, Xiao Y, Zhou T, Li P, Xu CD
Oncotarget 2015
Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor
DJ Voce, AM Schmitt, A Uppal, ME McNerney, GM Bernal, KE Cahill, JS Wahlstrom, A Nassiri, X Yu, CD Crawley, KP White, K Onel, RR Weichselbaum, B Yamini
Oncogene 2014
Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation
MW Buckley, S Arandjelovic, PC Trampont, TS Kim, TJ Braciale, KS Ravichandran
PloS one 2014
Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway
PP Piccaluga, M Rossi, C Agostinelli, F Ricci, A Gazzola, S Righi, F Fuligni, MA Laginestra, M Mancini, MR Sapienza, AD Renzo, PL Tazzari, D Gibellini, P Went, F Alviano, PL Zinzani, GP Bagnara, G Inghirami, C Tripodo, SA Pileri
Leukemia 2014
Annotation Enrichment Analysis: An Alternative Method for Evaluating the Functional Properties of Gene Sets
K Glass, M Girvan
Scientific Reports 2014
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma
J Iqbal, G Wright, C Wang, A Rosenwald, RD Gascoyne, DD Weisenburger, TC Greiner, L Smith, S Guo, RA Wilcox, BT Teh, ST Lim, SY Tan, LM Rimsza, ES Jaffe, E Campo, A Martinez, J Delabie, RM Braziel, JR Cook, RR Tubbs, G Ott, E Geissinger, P Gaulard, PP Piccaluga, SA Pileri, WY Au, S Nakamura, M Seto, F Berger, L Leval, JM Connors, J Armitage, J Vose, WC Chan, LM Staudt
Blood 2014
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions
N Hermann-Kleiter, G Baier
Cell Communication and Signaling 2014
Aggressive Subcutaneous Panniculitis-Like CD30+ Peripheral T-Cell Lymphoma with Diffuse EBER Expression
A Aneja, R LevakaVeera, V Patel, A Bains
Case Reports in Hematology 2014
Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas
Suketu Patel, Derek Murphy, Eugenia Haralambieva, Zainalabideen A Abdulla, Kah Keng Wong, Hong Chen, Edith Gould, Giovanna Roncador, Chris Sr Hatton, Amanda P Anderson, Alison H Banham, Karen Pulford
Biomarker insights 2014
Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus
M Navari, F Fuligni, MA Laginestra, M Etebari, MR Ambrosio, MR Sapienza, M Rossi, GD Falco, D Gibellini, C Tripodo, SA Pileri, L Leoncini, PP Piccaluga
Frontiers in microbiology 2014
Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified
MA Laginestra, PP Piccaluga, F Fuligni, M Rossi, C Agostinelli, S Righi, MR Sapienza, G Motta, A Gazzola, C Mannu, E Sabattini, F Bacci, V Tabanelli, CA Sacchetti, TZ Barrese, M Etebari, F Melle, A Clò, D Gibellini, C Tripodo, G Inghirami, CM Croce, SA Pileri
Blood Cancer Journal 2014
Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
JS Weinstein, K Lezon-Geyda, Y Maksimova, S Craft, Y Zhang, M Su, VP Schulz, J Craft, PG Gallagher
Blood 2014
From empiric to mechanism-based therapy for peripheral T cell lymphoma.
Intlekofer AM, Younes A
International Journal of Hematology 2014
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.
Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S, Kim SC, Lee B, Rho K, Lee JE, Cho KH, Kim W, Ju H, Kim J, Kim SJ, Kim WS, Lee S, Ko YH
Nature Genetics 2014
Mature T-cell Lymphomagenesis Induced by Retroviral Insertional Activation of Janus Kinase 1
T Heinrich, B Rengstl, A Muik, M Petkova, F Schmid, R Wistinghausen, K Warner, G Crispatzu, ML Hansmann, M Herling, D Laer, S Newrzela
Molecular Therapy 2013
microRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma
C Liu, J Iqbal, J Teruya-Feldstein, Y Shen, MJ Dabrowska, K Dybkaer, MS Lim, R Piva, A Barreca, E Pellegrino, E Spaccarotella, CM Lachel, C Kucuk, CS Jiang, X Hu, S Bhagavathi, TC Greiner, DD Weisenburger, P Aoun, SL Perkins, TW McKeithan, G Inghirami, WC Chan
Blood 2013
Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis
TK Das, D Dana, SS Paroly, SK Perumal, S Singh, H Jhun, J Pendse, RL Cagan, TT Talele, S Kumar
Oncogenesis 2013
Peripheral T-cell lymphomas: a review of current approaches and hopes for the future
AP Skarbnik, M Burki, B Pro
Frontiers in Oncology 2013
CD30-positive peripheral T-cell lymphomas share molecular and phenotypic features
B Bisig, A Reyniès, C Bonnet, P Sujobert, DS Rickman, T Marafioti, G Delsol, L Lamant, P Gaulard, L Leval
Haematologica 2013
Truncated Form of TGF-βRII, But Not Its Absence, Induces Memory CD8 + T Cell Expansion and Lymphoproliferative Disorder in Mice
H Ishigame, MM Mosaheb, S Sanjabi, RA Flavell
Journal of immunology (Baltimore, Md. : 1950) 2013
New molecular insights into peripheral T cell lymphomas
Stefano Pileri, Pier Paolo Piccaluga
Journal of Clinical Investigation 2012
Molecular Profiling of Aggressive Lymphomas
M Rossi, MA Laginestra, A Gazzola, MR Sapienza, SA Pileri, PP Piccaluga
Advances in Hematology 2012
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets
M Travert, Y Huang, L Leval, N Martin-Garcia, MH Delfau-Larue, F Berger, J Bosq, J Briere, J Soulier, E MacIntyre, T Marafioti, A Reynies, P Gaulard
Blood 2012
PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas
D Laimer, H Dolznig, K Kollmann, PW Vesely, M Schlederer, O Merkel, AI Schiefer, MR Hassler, S Heider, L Amenitsch, C Thallinger, PB Staber, I Simonitsch-Klupp, M Artaker, S Lagger, SD Turner, S Pileri, PP Piccaluga, P Valent, K Messana, I Landra, T Weichhart, S Knapp, M Shehata, M Todaro, V Sexl, G Höfler, R Piva, E Medico, BA Ruggeri, M Cheng, R Eferl, G Egger, JM Penninger, U Jaeger, R Moriggl, G Inghirami, L Kenner
Nature Medicine 2012
Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations
N Yoshida, A Umino, F Liu, K Arita, K Karube, S Tsuzuki, K Ohshima, M Seto
Cancer Medicine 2012
An integrated genome-wide approach to discover tumor-specific antigens as potential immunologic and clinical targets in cancer
QW Xu, W Zhao, Y Wang, MA Sartor, DM Han, J Deng, R Ponnala, JY Yang, QY Zhang, GQ Liao, YM Qu, L Li, FF Liu, HM Zhao, YH Yin, WF Chen, Y Zhang, XS Wang
Cancer research 2012
Genetic alterations in systemic nodal and extranodal non‐cutaneous lymphomas derived from mature T cells and natural killer cells
Boi M, Stathis A, Zucca E, Inghirami G, Bertoni F
Cancer Science 2012
T cell receptor dependent transformation of mature memory phenotype T cells in mice
Xi Wang, Miriam Werneck, Boris Wilson, Hye-Jung Kim, Michael Kluk, Christopher Thom, Jonathan Wischhusen, Julia Evans, Jonathan Jesneck, Phuong Nguyen, Courtney Sansam, Harvey Cantor, Charles Roberts
Journal of Clinical Investigation 2011
Identification and Characterization of Peripheral T-Cell Lymphoma-Associated SEREX Antigens
CD Cooper, CH Lawrie, AP Liggins, GP Collins, CS Hatton, K Pulford, AH Banham
PloS one 2011
Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets
C Schmitt, N Sako, M Bagot, Y Huang, P Gaulard, A Bensussan
Journal of biomedicine & biotechnology 2011
Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis
J An, H Fujiwara, K Suemori, T Niiya, T Azuma, K Tanimoto, T Ochi, Y Akatsuka, J Mineno, H Ozawa, F Ishikawa, K Kuzushima, M Yasukawa
International Journal of Hematology 2011
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications
E Campo, SH Swerdlow, NL Harris, S Pileri, H Stein, ES Jaffe
Blood 2011
Pathobiology of ALK-negative anaplastic large cell lymphoma
SA Pileri, C Agostinelli, F Bacci, E Sabattini, C Sagramoso, B Falini, PP Piccaluga
Pediatric reports 2011
Pathobiology of anaplastic large cell lymphoma
PP Piccaluga, A Gazzola, C Mannu, C Agostinelli, F Bacci, E Sabattini, C Sagramoso, R Piva, F Roncolato, G Inghirami, SA Pileri
Advances in Hematology 2010
Rapid Remission in Peripheral T-Cell Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy
LJ Xue, XB Mao, XB Liu, QS Su, HJ Yu, JH Yang
Case Reports in Medicine 2010
Prognostic markers in peripheral T-cell lymphoma
PP Piccaluga, C Agostinelli, A Gazzola, C Mannu, F Bacci, E Sabattini, SA Pileri
Current Hematologic Malignancy Reports 2010
Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma
C Tripodo, G Gri, PP Piccaluga, B Frossi, C Guarnotta, S Piconese, G Franco, V Vetri, CE Pucillo, AM Florena, MP Colombo, SA Pileri
The American Journal of Pathology 2010
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma
K Pechloff, J Holch, U Ferch, M Schweneker, K Brunner, M Kremer, T Sparwasser, L Quintanilla-Martinez, U Zimber-Strobl, B Streubel, A Gewies, C Peschel, J Ruland
Journal of Experimental Medicine 2010
Peripheral T cell lymphoma: new model + new insight
JC Mulloy
Journal of Experimental Medicine 2010
New Strategies in Peripheral T-cell lymphoma: Understanding Tumor Biology and Developing Novel Therapies
K Dunleavy, RL Piekarz, J Zain, JE Janik, WH Wilson, OA O'Connor, SE Bates
Clinical cancer research 2010
Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
PP Piccaluga, M Navari, GD Falco, MR Ambrosio, S Lazzi, F Fuligni, C Bellan, M Rossi, MR Sapienza, MA Laginestra, M Etebari, EA Rogena, L Tumwine, C Tripodo, D Gibellini, J Consiglio, CM Croce, SA Pileri, L Leoncini
Oncotarget 2010
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC
Blood 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type
Y Huang, A Reyniès, L Leval, B Ghazi, N Martin-Garcia, M Travert, J Bosq, J Brière, B Petit, E Thomas, P Coppo, T Marafioti, JF Emile, MH Delfau-Larue, C Schmitt, P Gaulard
Blood 2009
Physiological PTEN expression in peripheral T-cell lymphoma not otherwise specified
A Gazzola, C Bertuzzi, C Agostinelli, S Righi, SA Pileri, PP Piccaluga
Haematologica 2009
Peripheral T-cell Lymphomas With a Follicular Growth Pattern are Derived From Follicular Helper T Cells (TFH) and may Show Overlapping Features With Angioimmunoblastic T-cell Lymphomas:
Y Huang, A Moreau, J Dupuis, B Streubel, B Petit, SL Gouill, N Martin-Garcia, C Copie-Bergman, F Gaillard, M Qubaja, B Fabiani, G Roncador, C Haioun, MH Delfau-Larue, T Marafioti, A Chott, P Gaulard
The American Journal of Surgical Pathology 2009
Update on the World Health Organization classification of peripheral T-cell lymphomas.
O'Leary HM, Savage KJ
Current Hematologic Malignancy Reports 2009
Gamma-delta T-cell lymphomas.
Tripodo C, Iannitto E, Florena AM, Pucillo CE, Piccaluga PP, Franco V, Pileri SA
Nature reviews. Clinical oncology 2009
Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications
WJ Chng, ED Remstein, R Fonseca, PL Bergsagel, JA Vrana, PJ Kurtin, A Dogan
Blood 2008
Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies
C Agostinelli, PP Piccaluga, P Went, M Rossi, A Gazzola, S Righi, T Sista, C Campidelli, PL Zinzani, B Falini, SA Pileri
Journal of clinical pathology 2008

← Previous 1 2 3 4 5 6 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 3 patents
Referenced in 1 clinical guideline sources
92 readers on Mendeley
See more details