The molecular mechanisms that control thrombopoiesis
Kenneth Kaushansky
Kenneth Kaushansky
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3339-3347. https://doi.org/10.1172/JCI26674.
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The molecular mechanisms that control thrombopoiesis

Abstract

Our understanding of thrombopoiesis — the formation of blood platelets — has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the maturation of these cells into platelet-producing cells. The molecular and cellular mechanisms through which thrombopoietin affects platelet production provide new insights into the interplay between intrinsic and extrinsic influences on hematopoiesis and highlight new opportunities to translate basic biology into clinical advances.

Authors

Kenneth Kaushansky

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Figure 4

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A molecular model of JAK2 JH1 and JH2 domains. Based on the tertiary str...
A molecular model of JAK2 JH1 and JH2 domains. Based on the tertiary structure of the dimer receptor tyrosine kinase FGF receptor-4, the model depicts the ATP-binding site (yellow), the kinase active site (orange), the activation loop of JH1 in both inactive (purple) and active (red) conformations, and the location of JH2 residue Val617 (V617). Adapted with permission from Protein Engineering (66).