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Citations to this article

SOCS1 restricts dendritic cells’ ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling
Kevin Evel-Kabler, … , Xue F. Huang, Si-Yi Chen
Kevin Evel-Kabler, … , Xue F. Huang, Si-Yi Chen
Published January 4, 2006
Citation Information: J Clin Invest. 2006;116(1):90-100. https://doi.org/10.1172/JCI26169.
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Research Article Immunology Article has an altmetric score of 14

SOCS1 restricts dendritic cells’ ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling

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Abstract

DC-based tumor vaccine research has largely focused on enhancing DC maturation/costimulation and antigen presentation in order to break tolerance against self tumor-associated antigens. DC immunization can activate autoreactive T cells but rarely causes autoimmune pathologies, indicating that self tolerance at the host level is still maintained in the vaccinated hosts. This study in mice reveals a novel regulatory mechanism for the control of self tolerance at the host level by DCs through the restriction of positive cytokine feedback loops by cytokine signaling inhibitor SOCS1. The study further finds the requirement of persistent antigen presentation by DCs for inducing pathological autoimmune responses against normal tissues and tumor, which can be achieved by silencing SOCS1 to unleash the unbridled signaling of IL-12 and the downstream cytokine cascade. However, the use of higher-affinity self peptides, enhancement of DC maturation, and persistent stimulation with cytokines or TLR agonists fail to break tolerance and induce pathological antitumor immunity. Thus, this study indicates the necessity of inhibiting SOCS1, an antigen presentation attenuator, to break self tolerance and induce effective antitumor responses.

Authors

Kevin Evel-Kabler, Xiao-Tong Song, Melissa Aldrich, Xue F. Huang, Si-Yi Chen

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Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 2 2 4 1 3 3 7 3 4 6 6 8 9 8 7 8 4 2 87
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (8)

Title and authors Publication Year
Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System
IV Brussel, ZN Berneman, N Cools
Mediators of Inflammation 2012
Tumor Associated Regulatory Dendritic Cells
Y Ma, GV Shurin, DW Gutkin, MR Shurin
Seminars in Cancer Biology 2012
Constitutive Phosphorylation of Interferon Receptor A-Associated Signaling Proteins in Systemic Lupus Erythematosus
G Ramírez-Vélez, F Medina, L Ramírez-Montaño, A Zarazúa-Lozada, R Hernández, L Llorente, J Moreno
PloS one 2012
A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity
B Hong, SH Lee, XT Song, L Jones, K Machida, XF Huang, SY Chen
PloS one 2012
A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response
L Wang, B Hong, X Jiang, L Jones, SY Chen, XF Huang
PloS one 2012
Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity
F Cheng, H Wang, P Horna, Z Wang, B Shah, E Sahakian, KV Woan, A Villagra, J Pinilla-Ibarz, S Sebti, M Smith, J Tao, EM Sotomayor
Cancer research 2012
Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
LI Terrazas, F Sánchez-Muñoz, M Pérez-Miranda, AM Mejía-Domínguez, Y Ledesma-Soto, R Bojalil, L Gómez-García
BioMed Research International 2012
Enhanced activation of human dendritic cells by silencing SOCS1 and activating TLRs simultaneously
Zhang J, Yu J, Yang L, Li H, Wei F, Zhao H, Yu W, Ren X
Cancer Immunology, Immunotherapy 2012

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