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Citations to this article

Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
Claude Knauf, … , Catherine Postic, Rémy Burcelin
Claude Knauf, … , Catherine Postic, Rémy Burcelin
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3554-3563. https://doi.org/10.1172/JCI25764.
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Research Article Metabolism Article has an altmetric score of 3

Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

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Abstract

Intestinal glucagon-like peptide–1 (GLP-1) is a hormone released into the hepatoportal circulation that stimulates pancreatic insulin secretion. GLP-1 also acts as a neuropeptide to control food intake and cardiovascular functions, but its neural role in glucose homeostasis is unknown. We show that brain GLP-1 controlled whole-body glucose fate during hyperglycemic conditions. In mice undergoing a hyperglycemic hyperinsulinemic clamp, icv administration of the specific GLP-1 receptor antagonist exendin 9–39 (Ex9) increased muscle glucose utilization and glycogen content. This effect did not require muscle insulin action, as it also occurred in muscle insulin receptor KO mice. Conversely, icv infusion of the GLP-1 receptor agonist exendin 4 (Ex4) reduced insulin-stimulated muscle glucose utilization. In hyperglycemia achieved by i.v. infusion of glucose, icv Ex4, but not Ex9, caused a 4-fold increase in insulin secretion and enhanced liver glycogen storage. However, when glucose was infused intragastrically, icv Ex9 infusion lowered insulin secretion and hepatic glycogen levels, whereas no effects of icv Ex4 were observed. In diabetic mice fed a high-fat diet, a 1-month chronic i.p. Ex9 treatment improved glucose tolerance and fasting glycemia. Our data show that during hyperglycemia, brain GLP-1 inhibited muscle glucose utilization and increased insulin secretion to favor hepatic glycogen stores, preparing efficiently for the next fasting state.

Authors

Claude Knauf, Patrice D. Cani, Christophe Perrin, Miguel A. Iglesias, Jean François Maury, Elodie Bernard, Fadilha Benhamed, Thierry Grémeaux, Daniel J. Drucker, C. Ronald Kahn, Jean Girard, Jean François Tanti, Nathalie M. Delzenne, Catherine Postic, Rémy Burcelin

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 2 5 3 6 1 5 5 5 7 10 9 9 7 8 10 6 6 12 1 2 1 120
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (5)

Title and authors Publication Year
Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity
SJ Lee, G Sanchez-Watts, JP Krieger, A Pignalosa, PN Norell, A Cortella, KG Pettersen, D Vrdoljak, MR Hayes, S Kanoski, W Langhans, AG Watts
Molecular Metabolism 2018
Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake
A Abot, PD Cani, C Knauf
Frontiers in Endocrinology 2018
Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats
JP Krieger, EP da Conceição, G Sanchez-Watts, M Arnold, KG Pettersen, M Mohammed, S Modica, P Lossel, SF Morrison, CJ Madden, AG Watts, W Langhans, SJ Lee
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2018
Hypoglycemic Effects of Intestinal Electrical Stimulation by Enhancing Nutrient-Stimulated Secretion of GLP-1 in Rats
F Ye, Y Liu, S Li, JD Chen
Obesity Surgery 2018
Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons
A Abot, A Lucas, T Bautzova, A Bessac, A Fournel, S Le-Gonidec, P Valet, C Moro, PD Cani, C Knauf
Molecular Metabolism 2018

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 4 patents
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