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Skeletal muscle fat oxidation: timing and flexibility are everything
David E. Kelley
David E. Kelley
Published July 1, 2005
Citation Information: J Clin Invest. 2005;115(7):1699-1702. https://doi.org/10.1172/JCI25758.
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Skeletal muscle fat oxidation: timing and flexibility are everything

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Abstract

In order to examine the factors governing the timing and flexibility of skeletal muscle switching between fat and carbohydrate oxidation, Ukropcova et al. studied the effect of glucose and fatty acid availability on the preference for fat oxidation in myocytes cultured from human male quadriceps muscle taken from subjects with varied BMI, fat mass, and insulin sensitivity. The authors found that in vivo insulin sensitivity was related to a higher in vitro capacity for fat oxidation. These findings support the concept that the capacity of skeletal muscle to oxidize fat under appropriate physiological conditions is related to leanness, aerobic fitness, and insulin sensitivity.

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David E. Kelley

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Figure 1

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The flexibility of skeletal muscle to switch between oxidizing fat and g...
The flexibility of skeletal muscle to switch between oxidizing fat and glucose is related to insulin sensitivity, percentage of body fat, and fitness. Differences in the patterns of glucose and fat oxidation in skeletal muscle during fasting conditions are shown in a lean, aerobically fit individual (A), in whom there is a high reliance upon fat oxidation during fasting conditions, and in an obese, sedentary individual (B), in whom there is less reliance on fat and a greater reliance on glucose oxidation. The patterns of glucose and fat oxidation during insulin-stimulated conditions are also shown. In skeletal muscle of a lean, aerobically fit individual (C), insulin strongly suppresses fat oxidation and induces a high reliance upon glucose oxidation, whereas in skeletal muscle of an obese, sedentary individual (D), there is less stimulation of glucose oxidation by insulin and blunted suppression of fat oxidation. Thus, in skeletal muscle of obese, sedentary individuals, there is a constricted range in switching between fat and glucose oxidation compared to the dynamic switching evident in aerobically fit, lean individuals. This constrained homeostatic adjustment to the transitions between fasting and insulin-stimulated conditions in obese, sedentary individuals has been described as “metabolic inflexibility” of skeletal muscle.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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