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Lessons learned from cancer may help in the treatment of pulmonary hypertension
Serge Adnot
Serge Adnot
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1461-1463. https://doi.org/10.1172/JCI25399.
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Lessons learned from cancer may help in the treatment of pulmonary hypertension

Abstract

Hyperplasia of pulmonary artery SMCs (PASMCs) is a pathological hallmark of pulmonary arterial hypertension (PAH). In this issue of the JCI, McMurtry et al. report that adenovirus-mediated overexpression of survivin — a multipotent inhibitor of apoptosis — induces PAH in rats, whereas inhalation of an adenovirus vector encoding a mutant survivin gene with dominant-negative properties reverses established monocrotaline-induced PAH. These findings raise important issues regarding the role of survivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies.

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Serge Adnot

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Citations to this article (14)

Title and authors Publication Year
Blockade of JAK2 protects mice against hypoxia‐induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation
Zhang L, Wang Y, Wu G, Rao L, Wei Y, Yue H, Yuan T, Yang P, Xiong F, Zhang S, Zhou Q, Chen Z, Li J, Mo B, Zhang H, Xiong W, Wang C 		Cell Proliferation 2020
Role for Telomerase in Pulmonary Hypertension
N Mouraret, A Houssaini, S Abid, R Quarck, E Marcos, A Parpaleix, G Gary-Bobo, JL Dubois-Rande, G Derumeaux, J Boczkowski, M Delcroix, MA Blasco, L Lipskaia, V Amsellem, S Adnot 		Circulation 2014
Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary arterial hypertension associated with connective tissue diseases
A Boueiz, PM Hassoun 		Annals of thoracic medicine 2014
Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension
A Houssaini, S Abid, N Mouraret, F Wan, D Rideau, M Saker, E Marcos, CM Tissot, JL Dubois-Randé, V Amsellem, S Adnot 		American journal of respiratory cell and molecular biology 2013
Pulmonary Arterial Hypertension in Connective Tissue Diseases
SC Mathai, PM Hassoun 		Heart Failure Clinics 2012
Pulmonary arterial hypertension associated with systemic sclerosis
Mathai SC, Hassoun PM 		Expert Review of Respiratory Medicine 2011
Effects of HIV Protease Inhibitors on Progression of Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension in Rats
G Gary-Bobo, A Houssaini, V Amsellem, D Rideau, P Pacaud, A Perrin, J Brégeon, E Marcos, JL Dubois-Randé, O Sitbon, L Savale, S Adnot 		Circulation 2010
Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease
J Tian, S Fratz, Y Hou, Q Lu, A Görlach, J Hess, C Schreiber, SA Datar, P Oishi, J Nechtman, R Podolsky, JX She, JR Fineman, SM Black 		Physiological genomics 2010
Lung Involvement in Systemic Sclerosis
PM Hassoun 		Presse medicale (Paris, France : 1983) 2010
Cellular and molecular basis of pulmonary arterial hypertension
NW Morrell, S Adnot, SL Archer, J Dupuis, PL Jones, MR MacLean, IF McMurtry, KR Stenmark, PA Thistlethwaite, N Weissmann, JX Yuan, EK Weir 		Journal of the American College of Cardiology 2009
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
BN Davis, AC Hilyard, PH Nguyen, G Lagna, A Hata 		The Journal of biological chemistry 2009
Therapies for scleroderma-related pulmonary arterial hypertension
PM Hassoun 		Expert Review of Respiratory Medicine 2009
A Dosing/Cross-Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension
M Gomberg-Maitland, ML Maitland, RJ Barst, L Sugeng, S Coslet, TJ Perrino, L Bond, ME Lacouture, SL Archer, MJ Ratain 		Clinical Pharmacology & Therapeutics 2009
Therapy for Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
Mathai SC, Hassoun PM 		Current Opinion in Rheumatology 2009

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