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Citations to this article

Food for thought: endocannabinoid modulation of lipogenesis
Aron H. Lichtman, Benjamin F. Cravatt
Aron H. Lichtman, Benjamin F. Cravatt
Published May 2, 2005
Citation Information: J Clin Invest. 2005;115(5):1130-1133. https://doi.org/10.1172/JCI25076.
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Food for thought: endocannabinoid modulation of lipogenesis

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Abstract

An emerging body of evidence implicates peripheral and central endocannabinoid pathways in the regulation of feeding behavior and body weight. A report in this issue of the JCI demonstrates the presence of a common endocannabinoid-regulated molecular pathway for peripheral lipogenic and central appetitive regulation. This pathway involves the activation of the transcription factor SREBP-1c and its associated enzymes, acetyl-CoA carboxylase-1 and fatty acid synthase, in the liver and hypothalamus. Activation of cannabinoid receptor 1 (CB1) in liver plays a key role in increased serum lipid production, fatty liver, and possibly diet-induced obesity. Conversely, stimulation of these receptors in the hypothalamus may lead to an increase in food consumption. Thus, targeting both of these pathways with CB1 antagonists could promote sustained weight loss and favorable serum lipid profiles in obese patients.

Authors

Aron H. Lichtman, Benjamin F. Cravatt

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Total citations by year

Year: 2022 2018 2017 2012 2009 2007 2006 Total
Citations: 1 1 1 1 1 1 1 7
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (1)

Title and authors Publication Year
The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets
L Getty-Kaushik, AM Richard, JT Deeney, S Krawczyk, O Shirihai, BE Corkey
Obesity 2009

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