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Citations to this article

Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis
Girish S. Kirimanjeswara, … , Ottar N. Bjornstad, Eric T. Harvill
Girish S. Kirimanjeswara, … , Ottar N. Bjornstad, Eric T. Harvill
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3594-3601. https://doi.org/10.1172/JCI24609.
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Research Article Infectious disease Article has an altmetric score of 7

Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis

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Abstract

Whooping cough is considered a childhood disease, although there is growing evidence that children are infected by adult carriers. Additionally, increasing numbers of vaccinated adults are being diagnosed with Bordetella pertussis disease. Thus it is critical to understand how B. pertussis remains endemic even in highly vaccinated or immune populations. Here we used the mouse model to examine the nature of sterilizing immunity to B. pertussis. Antibodies were necessary to control infection but did not rapidly clear B. pertussis from the lungs. However, antibodies affected B. pertussis after a delay of at least a week by a mechanism that involved neutrophils and Fc receptors, suggesting that neutrophils phagocytose and clear antibody-opsonized bacteria via Fc receptors. B. pertussis blocked migration of neutrophils and inhibited their recruitment to the lungs during the first week of infection by a pertussis toxin–dependent (PTx-dependent) mechanism; a PTx mutant of B. pertussis induced rapid neutrophil recruitment and was rapidly cleared from the lungs by adoptively transferred antibodies. Depletion of neutrophils abrogated the defects of the PTx mutant. Together these results indicate that PTx inhibits neutrophil recruitment, which consequently allows B. pertussis to avoid rapid antibody-mediated clearance and therefore successfully infect immune hosts.

Authors

Girish S. Kirimanjeswara, Luis M. Agosto, Mary J. Kennett, Ottar N. Bjornstad, Eric T. Harvill

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 2005 Total
Citations: 2 4 6 6 6 5 7 6 3 1 3 6 5 4 4 9 4 5 1 87
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Citations to this article (87)

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