Go to
JCI Insight
Citations to this article
Luca Gattinoni, … , Steven A. Rosenberg, Nicholas P. Restifo
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1616-1626. https://doi.org/10.1172/JCI24480.
Citation Information: J Clin Invest. 2005;115(6):1616-1626. https://doi.org/10.1172/JCI24480.
Abstract
T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages of differentiation, we evaluated their efficacy for adoptive immunotherapy. We found that administration of naive and early effector T cells, in combination with active immunization and IL-2, resulted in the eradication of large, established tumors. Despite enhanced in vitro antitumor properties, more-differentiated effector T cells were less effective for in vivo tumor treatment. Several events may underlie this paradoxical phenomenon: (a) downregulation of lymphoid-homing and costimulatory molecules; (b) inability to produce IL-2 and access homeostatic cytokines; and (c) entry into a proapoptotic and replicative senescent state. While the progressive acquisition of terminal effector properties is characterized by pronounced in vitro tumor killing, in vivo T cell activation, proliferation, and survival are progressively impaired. These findings suggest that the current methodology for selecting T cells for transfer is inadequate and provide new criteria for the generation and the screening of optimal lymphocyte populations for adoptive immunotherapy.
Authors
Luca Gattinoni, Christopher A. Klebanoff, Douglas C. Palmer, Claudia Wrzesinski, Keith Kerstann, Zhiya Yu, Steven E. Finkelstein, Marc R. Theoret, Steven A. Rosenberg, Nicholas P. Restifo
Total citations by year
Citation information
Citations to this article (536)
| Title and authors | Publication | Year |
|---|---|---|
|
LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells
Zhu S, Zuo S, Li C, You X, Jiang E, Feng X, Luo Y |
Journal of Experimental & Clinical Cancer Research : CR | 2025 |
|
A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells
Song F, Tsahouridis O, Stucchi S, Walhart T, Mendell S, Hardy PB, Axtman M, Guduru SK, Gilbert TS, Graves LM, Herring LE, Savoldo B, Ma X, Woodcock M, Milner JJ, Ivanova A, Pearce KH, Xu Y, Dotti G |
Nature Immunology | 2025 |
|
CAR‐T Cell Therapy for PTLD: Analysis of CAR‐T Product, Engraftment, and Outcomes in Patients Receiving Parallel Immunosuppression
Panopoulou A, Mehra V, Cwynarski K, Morley\u2010Smith A, Hwang A, O'Reilly M, Roddy H, Roddie C |
EJHaem | 2025 |
|
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy.
|
Nature immunology | 2025 |
|
A New Method of Canine CD4+ T Lymphocyte Differentiation Towards the Th17 Phenotype with Analysis of Properties and Mitochondrial Activity
Szopa IM, Majchrzak-Kuligowska K, Pingwara R, Kulka M, Taşdemir M, Gajewska M |
International Journal of Molecular Sciences | 2025 |
|
Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with anti-PDL1 therapy effectively inhibits triple-negative breast cancer growth and metastasis
Gammelgaard OL, Terp MG, Kirkin AF, Johansen S, Traynor S, Vever H, Guldberg P, Kodahl AR, Gjerstorff MF, Ditzel HJ |
Molecular Cancer | 2024 |
|
Optimization of anti-CD19 CAR T cell production for treatment of patients with chronic lymphocytic leukemia.
Amatya C, Weissler KA, Fellowes V, Lam N, Cutmore LC, Natrakul DA, Highfill SL, Kochenderfer JN |
2024 | |
|
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies.
Xiang M, Li H, Zhan Y, Ma D, Gao Q, Fang Y |
Molecular Cancer | 2024 |
|
Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions.
Wang S, Prieux M, de Bernard S, Dubois M, Laubreton D, Djebali S, Zala M, Arpin C, Genestier L, Leverrier Y, Gandrillon O, Crauste F, Jiang W, Marvel J |
iScience | 2024 |
|
Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy.
Kurihara S, Ishikawa A, Kaneko S |
Ensho Saisei | 2024 |
|
Single-cell adhesive profiling in an optofluidic device elucidates CD8+ T lymphocyte phenotypes in inflamed vasculature-like microenvironments
Camargo CP, Alapan Y, Muhuri AK, Lucas SN, Thomas SN |
2024 | |
|
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8(+) T cell adoptive therapies in pre-clinical studies.
Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, Novak AJ, Brunetti TM, Thompson SB, Henao-Mejia J, Flavell RA, D'Alessandro A, Kohler ME, Rincon M |
Nature Communications | 2024 |
|
Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy
Tang X, Mao X, Ling P, Yu M, Pan H, Wang J, Liu M, Pan H, Qiu W, Che N, Zhang K, Bao F, Peng H, Ding Q, Wang S, Zhou W |
Nature Communications | 2024 |
|
Nanowires engineer naive T cells for immunotherapy.
Slavkovic-Lukic D, Gattinoni L |
Nature Nanotechnology | 2024 |
|
Engineering Improved CAR T Cell Products with a Multi-Cytokine Particle Platform for Hematologic and Solid Tumors
Lin HK, Uricoli B, Freeman RM, Hossian AN, He Z, Anderson JY, Neffling M, Legier JM, Blake DA, Doxie DB, Nair R, Koff JL, Dhodapkar KM, Shanmugam M, Dreaden EC, Rafiq S |
Advanced Healthcare Materials | 2024 |
|
DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing
Laletin V, Bernard PL, Montersino C, Yamanashi Y, Olive D, Castellano R, Guittard G, Nunès JA |
Scientific Reports | 2024 |
|
The invisible hand: How epigenetics shapes CAR T cell destiny
Ali A, Zhang Y, DiPersio J |
Molecular Therapy | 2024 |
|
EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation
Cooper RS, Sutherland C, Smith LM, Cowan G, Barnett M, Mitchell D, McLean C, Imlach S, Hayes A, Zahra S, Manchanayake C, Vickers MA, Graham G, McGowan NW, Turner ML, Campbell JD, Fraser AR |
Frontiers in immunology | 2024 |
|
Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma.
Ishigaki H, Yamauchi T, Long MD, Hoki T, Yamamoto Y, Oba T, Ito F |
Cancer research communications | 2024 |
|
CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under the control of antigen sensing in microwell arrays
Cho Y, Laird MS, Bishop T, Li R, Jazwinska DE, Ruffo E, Lohmueller J, Zervantonakis IK |
2024 | |
|
Beyond CAR-T: The rise of CAR-NK cell therapy in asthma immunotherapy.
Mohammad Taheri M, Javan F, Poudineh M, Athari SS |
Journal of Translational Medicine | 2024 |
|
Strategies for Improving CAR T Cell Persistence in Solid Tumors
Wittling MC, Cole AC, Brammer B, Diatikar KG, Schmitt NC, Paulos CM |
Cancers | 2024 |
|
Stem-like CD8+ T cells in cancer
Steiner C, Denlinger N, Huang X, Yang Y |
Frontiers in Immunology | 2024 |
|
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness
Pallavicini I, Frasconi TM, Catozzi C, Ceccacci E, Tiberti S, Haas D, Samson J, Heuser-Loy C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Mercurio C, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T |
Nature Communications | 2024 |
|
NaCl enhances CD8(+) T cell effector functions in cancer immunotherapy.
Scirgolea C, Sottile R, De Luca M, Susana A, Carnevale S, Puccio S, Ferrari V, Lise V, Contarini G, Scarpa A, Scamardella E, Feno S, Camisaschi C, De Simone G, Basso G, Giuliano D, Mazza EMC, Gattinoni L, Roychoudhuri R, Voulaz E, Di Mitri D, Simonelli M, Losurdo A, Pozzi D, Tsui C, Kallies A, Timo S, Martano G, Barberis E, Manfredi M, Rescigno M, Jaillon S, Lugli E |
Nature immunology | 2024 |
|
Engineering potent chimeric antigen receptor T cells by programming signaling during T-cell activation
Li AW, Briones JD, Lu J, Walker Q, Martinez R, Hiraragi H, Boldajipour BA, Sundar P, Potluri S, Lee G, Ali OA, Cheung AS |
Scientific Reports | 2024 |
|
Advancement and Challenges in Monitoring of CAR-T Cell Therapy: A Comprehensive Review of Parameters and Markers in Hematological Malignancies.
Ploch W, Sadowski K, Olejarz W, Basak GW |
Cancers | 2024 |
|
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB.
Wang X, Tao X, Chen P, Jiang P, Li W, Chang H, Wei C, Lai X, Zhang H, Pan Y, Ding L, Liang Z, Cui J, Shao M, Teng X, Gu T, Wei J, Kong D, Si X, Han Y, Fu H, Lin Y, Yu J, Li X, Wang D, Hu Y, Qian P, Huang H |
Signal transduction and targeted therapy | 2024 |
|
Epigenetics behind CD8(+) T cell activation and exhaustion.
Zu H, Chen X |
Genes and immunity | 2024 |
|
A novel mitochondrial pyruvate carrier inhibitor drives stem cell-like memory CAR T cell generation and enhances antitumor efficacy
Wenes M, Lepez A, Arinkin V, Maundrell K, Barabas O, Simonetta F, Dutoit V, Romero P, Martinou JC, Migliorini D |
Molecular Therapy Oncology | 2024 |
|
MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.
Liu M, Akahori Y, Imai N, Wang L, Negishi K, Kato T, Fujiwara H, Miwa H, Shiku H, Miyahara Y |
Journal for immunotherapy of cancer | 2024 |
|
Effect of hypoxia-induced mIL15 expression on expansion and memory progenitor stem-like TILs in vitro
Sun Z, Xu A, Wu Z, Lan X, Gao G, Guo B, Yu Z, Shao L, Wu H, Lv M, Wang Y, Zhao Y, Wang B |
Frontiers in Immunology | 2024 |
|
Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system
O\u2019Sullivan A, Case S, McCrudden A, Hackett E, Gallagher L, Martin D, Johnson GP, Mahadik K, Kienzle T, Lim JK, Nashat A, Srinivasan K, Lowdell MW, O\u2019Flynn L, Frankish J |
Molecular Therapy. Methods & Clinical Development | 2024 |
|
Heterogeneous tumor microenvironment modulates T-cell phenotype and CD57+ T follicular helper cells have an adverse effect in follicular lymphoma
Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Shahrzad Jalali, Joshua Pritchett, Rekha Mudappathi, Junwen Wang, Jose Villasboas, Patrizia Mondello, Anne Novak, Stephen Ansell |
Blood Cancer Journal | 2023 |
|
The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma
Worel N, Grabmeier-Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, Körmöczi U, Porpaczy E, Staber PB, Skrabs C, Herkner H, Gudipati V, Huppa JB, Salzer B, Lehner M, Saxenhuber N, Friedberg E, Wohlfarth P, Hopfinger G, Rabitsch W, Simonitsch-Klupp I, Jäger U, Pickl WF |
Frontiers in immunology | 2023 |
|
Enhancing CAR-T cell functionality in a patient-specific manner
Zhang DK, Adu-Berchie K, Iyer S, Liu Y, Cieri N, Brockman JM, Neuberg D, Wu CJ, Mooney DJ |
Nature Communications | 2023 |
|
LEF1 drives a central memory program and supports antitumor activity of natural killer T cells
Ngai H, Barragan GA, Tian G, Balzeau JC, Zhang C, Courtney AN, Guo L, Xu X, Wood MS, Drabek JM, Demberg T, Sands CM, Chauvin-Fleurence CN, Di Pierro EJ, Rosen JM, Metelitsa LS |
Cancer immunology research | 2023 |
|
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer
Liu H, Liang Z, Cheng S, Huang L, Li W, Zhou C, Zheng X, Li S, Zeng Z, Kang L |
Advanced Science | 2023 |
|
Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFβ
O\u2019Sullivan JA, Kohlhapp FJ, Zloza A, Plaza-Rojas L, Burke B, Dulin NO, Guevara-Patiño JA |
International journal of molecular sciences | 2023 |
|
Metabolic Challenges in Anticancer CD8 T Cell Functions
Amitrano AM, Kim M |
Immune Network | 2023 |
|
Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering
Michels KR, Sheih A, Hernandez SA, Brandes AH, Parrilla D, Irwin B, Perez AM, Ting HA, Nicolai CJ, Gervascio T, Shin S, Pankau MD, Muhonen M, Freeman J, Gould S, Getto R, Larson RP, Ryu BY, Scharenberg AM, Sullivan AM, Green S |
Journal for ImmunoTherapy of Cancer | 2023 |
|
Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells
Hiltensperger M, Krackhardt AM |
Frontiers in immunology | 2023 |
|
Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes
Nanjireddy PM, Olejniczak SH, Buxbaum NP |
Frontiers in immunology | 2023 |
|
Time-resolved assessment of single-cell protein secretion by sequencing.
Wu T, Womersley HJ, Wang JR, Scolnick J, Cheow LF |
Nature Methods | 2023 |
|
Long-term outcomes following CAR T cell therapy: what we know so far
Cappell KM, Kochenderfer JN |
Nature reviews. Clinical oncology | 2023 |
|
Dynamics and specificities of T cells in cancer immunotherapy.
Oliveira G, Wu CJ |
Nature reviews. Cancer | 2023 |
|
Adoptive neoantigen-reactive T cell therapy: improvement strategies and current clinical researches.
Huang R, Zhao B, Hu S, Zhang Q, Su X, Zhang W |
Biomarker Research | 2023 |
|
Characterization of the input material quality for the production of tisagenlecleucel by multiparameter flow cytometry and its relation to the clinical outcome
Štach M, Pytlík R, Šmilauerová K, Rychlá J, Mucha M, Musil J, Koladiya A, Nemec M, Petráčková M, Kaštánková I, Pecherková P, Šrámková L, Polgárová K, Trněný M, Lesný P, Vydra J, Otáhal P |
2023 | |
|
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results.
Heczey A, Xu X, Courtney AN, Tian G, Barragan GA, Guo L, Amador CM, Ghatwai N, Rathi P, Wood MS, Li Y, Zhang C, Demberg T, Di Pierro EJ, Sher AC, Zhang H, Mehta B, Thakkar SG, Grilley B, Wang T, Weiss BD, Montalbano A, Subramaniam M, Xu C, Sachar C, Wells DK, Dotti G, Metelitsa LS |
Nature Medicine | 2023 |
|
Adhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy
Camargo CP, Muhuri AK, Alapan Y, Sestito LF, Khosla M, Manspeaker MP, Smith AS, Paulos CM, Thomas SN |
Cell Reports | 2023 |
|
TMIGD2 as a potential therapeutic target in glioma patients
Boulhen C, AIT SSI S, Benthami H, Razzouki I, Lakhdar A, Karkouri M, Badou A |
Frontiers in immunology | 2023 |
|
Cord blood–derived Vδ2+ and Vδ2− T cells acquire differential cell state compositions upon in vitro expansion
Ng JW, Tan KW, Guo DY, Lai JJ, Fan X, Poon Z, Lim TH, Lim AS, Lim TK, Hwang WY, Li S, Eaves CJ, Goh YT, Cheung AM |
Science Advances | 2023 |
|
IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation
Lee J, Lee K, Bae H, Lee K, Lee S, Ma J, Jo K, Kim I, Jee B, Kang M, Im SJ |
Frontiers in immunology | 2023 |
|
An optimized cultivation method for future in vivo application of γδ T cells
Bold A, Gross H, Holzmann E, Knop S, Hoeres T, Wilhelm M |
Frontiers in immunology | 2023 |
|
AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival
Mehra V, Agliardi G, Dias Alves Pinto J, Shafat MS, Garai AC, Green L, Hotblack A, Arce Vargas F, Peggs KS, van der Waart AB, Dolstra H, Pule MA, Roddie C |
Journal for ImmunoTherapy of Cancer | 2023 |
|
Tumor-Specific CD8+ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes
Zawidzka EM, Biavati L, Thomas A, Zanettini C, Marchionni L, Leone R, Borrello I |
2023 | |
|
Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for Immunotherapy
Wu T, Tan JH, Sin W, Luah YH, Tan SY, Goh M, Birnbaum ME, Chen Q, Cheow LF |
Advanced Science | 2023 |
|
Favorable Activity and Safety Profile of Memory-Enriched CD19-Targeted Chimeric Antigen Receptor T Cell Therapy in Adults with high-risk Relapsed/Refractory ALL
Aldoss I, Khaled SK, Wang X, Palmer J, Wang Y, Wagner JR, Clark MC, Simpson J, Paul J, Vyas V, Chien SH, Stein A, Pullarkat V, Salhotra A, Al Malki MM, Aribi A, Sandhu K, Thomas SH, Budde LE, Marcucci G, Brown CE, Forman SJ |
Clinical cancer research | 2023 |
|
Harnessing CD3 diversity to optimize CAR T cells
Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S |
Nature Immunology | 2023 |
|
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn.
Albelda SM |
Nature reviews. Clinical oncology | 2023 |
|
Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures
Majumder A |
Cancers | 2023 |
|
Rapid anti-myeloma activity by T cells expressing an anti-BCMA CAR with a human heavy-chain-only antigen-binding domain
Mikkilineni L, Natrakul DA, Lam N, Manasanch EE, Mann J, Weissler KA, Wong N, Brudno JN, Goff SL, Yang JC, Ganaden M, Patel R, Zheng Z, Gartner JJ, Martin KR, Wang HW, Yuan CM, Lowe T, Maric I, Shao L, Jin P, Stroncek DF, Highfill SL, Rosenberg SA, Kochenderfer JN |
Molecular Therapy | 2023 |
|
IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity
Liuling Xiao, Xingzhe Ma, Lingqun Ye, Pan Su, Wei Xiong, Enguang Bi, Qiang Wang, Miao Xian, Maojie Yang, Jianfei Qian, Qing Yi |
Journal of Clinical Investigation | 2022 |
|
T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy
Fumihiro Fujiki, Soyoko Morimoto, Akiko Katsuhara, Akane Okuda, Saeka Ogawa, Eriko Ueda, Maki Miyazaki, Ayako Isotani, Masahito Ikawa, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Jun Nakata, Naoki Hosen, Atsushi Kumanogoh, Yusuke Oji, Haruo Sugiyama |
Frontiers in immunology | 2022 |
|
Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function
S MacPherson, S Keyes, M Kilgour, J Smazynski, V Chan, J Sudderth, T Turcotte, A Devlieger, J Yu, K Huggler, J R., R DeBerardinis, C Siatskas, J Lum |
Molecular Therapy — Methods & Clinical Development | 2022 |
|
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
P Shafer, L Kelly, V Hoyos |
Frontiers in immunology | 2022 |
|
Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners
S Stock, A Kluever, S Endres, S Kobold |
Biomedicines | 2022 |
|
Adoptive Cellular Therapy for Multiple Myeloma Using CAR- and TCR-Transgenic T Cells: Response and Resistance
F Füchsl, A Krackhardt |
Cells | 2022 |
|
Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors
Y Kimura, M Ghosn, W Cheema, P Adusumilli, S Solomon, G Srimathveeralli |
Molecular Therapy — Oncolytics | 2022 |
|
Emerging Strategies in TCR-Engineered T Cells
F Wei, X Cheng, J Xue, S Xue |
Frontiers in immunology | 2022 |
|
Potentiating adoptive cell therapy using synthetic IL-9 receptors
A Kalbasi, M Siurala, L Su, M Tariveranmoshabad, L Picton, P Ravikumar, P Li, J Lin, H Escuin-Ordinas, T Da, S Kremer, A Sun, S Castelli, S Agarwal, J Scholler, D Song, P Rommel, E Radaelli, R Young, W Leonard, A Ribas, C June, K Garcia |
Nature | 2022 |
|
The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors
E Hunt, A Andrews, S Larsen, J Thaxton |
Frontiers in Cell and Developmental Biology | 2022 |
|
STAT3 Role in T-Cell Memory Formation
Y Kaminskiy, J Melenhorst |
International journal of molecular sciences | 2022 |
|
The Emerging Role of CAR T Cell Therapy in Relapsed/Refractory Hodgkin Lymphoma
J Meier, B Savoldo, N Grover |
Journal of Personalized Medicine | 2022 |
|
Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase
J Durgin, R Thokala, L Johnson, E Song, J Leferovich, V Bhoj, S Ghassemi, M Milone, Z Binder, D O'Rourke, R O'Connor |
Molecular Therapy | 2022 |
|
Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy.
Zhang T, Yang Y, Huang L, Liu Y, Chong G, Yin W, Dong H, Li Y, Li Y |
Pharmaceutics | 2022 |
|
Single-cell Transcriptomic Architecture Unraveling the Complexity of Tumor Heterogeneity in Distal Cholangiocarcinoma.
Li H, Qu L, Yang Y, Zhang H, Li X, Zhang X |
Cellular and Molecular Gastroenterology and Hepatology | 2022 |
|
Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction.
Zangari B, Tsuji T, Matsuzaki J, Mohammadpour H, Eppolito C, Battaglia S, Ito F, Chodon T, Koya R, Robert McGray AJ, Odunsi K |
Cancer Immunology, Immunotherapy | 2022 |
|
Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients.
Peter L, Wendering DJ, Schlickeiser S, Hoffmann H, Noster R, Wagner DL, Zarrinrad G, Münch S, Picht S, Schulenberg S, Moradian H, Mashreghi MF, Klein O, Gossen M, Roch T, Babel N, Reinke P, Volk HD, Amini L, Schmueck-Henneresse M |
2022 | |
|
Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer.
Stromnes IM, Hulbert A, Rollins MR, Basom RS, Delrow J, Bonson P, Burrack AL, Hingorani SR, Greenberg PD |
Journal for ImmunoTherapy of Cancer | 2022 |
|
CD81 costimulation skews CAR transduction toward naive T cells.
Schultz LM, Czerwinski DK, Levy R, Levy S |
Proceedings of the National Academy of Sciences | 2022 |
|
Melanoma therapeutics: a literature review
Dhanyamraju PK, Patel TN |
Journal of Biomedical Research | 2022 |
|
Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry
Chanda MK, Shudde CE, Piper TL, Zheng Y, Courtney AH |
Journal of Immunological Methods | 2022 |
|
Combined overexpression of four transcription factors promotes effector T cell dedifferentiation toward early phenotypes.
Yan L, Ou Y, Xia S, Huang J, Zhang W, Shao H, Shen H, Bo H, Tao C, Wang J, Wu F |
Immunogenetics | 2022 |
|
CAR-T Cell Performance: How to Improve Their Persistence?
López-Cantillo G, Urueña C, Camacho BA, Ramírez-Segura C |
Frontiers in immunology | 2022 |
|
Immune Cell Metabolic Fitness for Life
Bittman KS |
Antibodies | 2022 |
|
CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments.
Jogalekar MP, Rajendran RL, Khan F, Dmello C, Gangadaran P, Ahn BC |
Frontiers in immunology | 2022 |
|
PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy.
Jassim BA, Lin J, Zhang ZY |
Expert Opinion on Drug Discovery | 2022 |
|
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors.
Stock S, Benmebarek MR, Kluever AK, Darowski D, Jost C, Stubenrauch KG, Benz J, Freimoser-Grundschober A, Moessner E, Umana P, Subklewe M, Endres S, Klein C, Kobold S |
Journal for ImmunoTherapy of Cancer | 2022 |
|
EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
Jing R, Scarfo I, Najia M, da Rocha EL, Han A, Sanborn M, Bingham T, Kubaczka C, Jha D, Falchetti M, Schlaeger TM, North TE, Maus MV, Daley GQ |
Cell Stem Cell | 2022 |
|
Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy
Blokon-Kogan D, Levi-Mann M, Malka-Levy L, Itzhaki O, Besser MJ, Shiftan Y, Szöőr Á, Vereb G, Gross G, Abken H, Weinstein-Marom H |
Journal for ImmunoTherapy of Cancer | 2022 |
|
Co-Stimulatory Receptor Signaling in CAR-T Cells
Honikel MM, Olejniczak SH |
Biomolecules | 2022 |
|
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells
Madison BB, Patil D, Richter M, Li X, Tong M, Cranert S, Wang X, Martin R, Xi H, Tan Y, Weiss L, Marquez K, Coronella J, Shedlock DJ, Ostertag EM |
2022 | |
|
Treatment with Exogenously Added Catalase Alters CD8 T Cell Memory Differentiation and Function.
Aksoylar HI, Patsoukis N |
2022 | |
|
EBAG9 silencing exerts an immune checkpoint function without aggravating adverse effects
Wirges A, Bunse M, Joedicke JJ, Blanc E, Gudipati V, Moles MW, Shiku H, Beule D, Huppa JB, Höpken UE, Rehm A |
Molecular Therapy | 2022 |
|
Recent Progress of Gene Circuit Designs in Immune Cell Therapies
Lee S, Khalil AS, Wong WW |
Cell Systems | 2022 |
|
Mechanisms of CAR T cell exhaustion and current counteraction strategies
Zhu X, Li Q, Zhu X |
Frontiers in Cell and Developmental Biology | 2022 |
|
Chimeric antigen receptor T-cell therapy for multiple myeloma
Wang Z, Chen C, Wang L, Jia Y, Qin Y |
Frontiers in immunology | 2022 |
|
Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Palmer DC, Webber BR, Patel Y, Johnson MJ, Kariya CM, Lahr WS, Parkhurst MR, Gartner JJ, Prickett TD, Lowery FJ, Kishton RJ, Gurusamy D, Franco Z, Vodnala SK, Diers MD, Wolf NK, Slipek NJ, McKenna DH, Sumstad D, Viney L, Henley T, Bürckstümmer T, Baker O, Hu Y, Yan C, Meerzaman D, Padhan K, Lo W, Malekzadeh P, Jia L, Deniger DC, Patel SJ, Robbins PF, McIvor RS, Choudhry M, Rosenberg SA, Moriarity BS, Restifo NP |
2022 | |
|
FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma
Conde E, Casares N, Mancheño U, Elizalde E, Vercher E, Capozzi R, Santamaria E, Rodriguez-Madoz JR, Prosper F, Lasarte JJ, Lozano T, Hervas-Stubbs S |
Molecular Therapy | 2022 |
|
Multivalent, Bispecific αB7-H3-αCD3 Chemically Self-Assembled Nanorings Direct Potent T cell Responses Against Medulloblastoma
Mews EA, Beckmann P, Patchava M, Wang Y, Largaespada DA, Wagner CR |
ACS Nano | 2022 |
|
Cellular Cancer Immunotherapy Development and Manufacturing in the Clinic
Fenton GA, Mitchell DA |
Clinical cancer research | 2022 |
|
Memory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions
Beumer\u2010Chuwonpad A, van Alphen FP, Kragten NA, Freen\u2010van Heeren JJ, Rodriguez Gomez M, Verhoeven AJ, van den Biggelaar M, van Gisbergen KP |
European Journal of Immunology | 2022 |
|
Immune cellular components and signaling pathways in the tumor microenvironment.
Yenyuwadee S, Aliazis K, Wang Q, Christofides A, Shah R, Patsoukis N, Boussiotis VA |
Seminars in Cancer Biology | 2022 |
|
Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity.
Liu CH, Lin BS, Wu MY, Song YC, Ke TW, Chou YL, Liu CT, Lin CH, Radojcic V, Drake C, Yen HR |
Immunology | 2022 |
|
Induction of EBV latent membrane protein-2A (LMP2A)-specific T cells and construction of individualized TCR-engineered T cells for EBV-associated malignancies
C Zhang, Q Tan, S Li, L Shen, J Zhang, Y Liu, W Yang, Z Lu |
Journal for ImmunoTherapy of Cancer | 2021 |
|
Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
JT Huckaby, E Landoni, TM Jacobs, B Savoldo, G Dotti, SK Lai |
Journal for ImmunoTherapy of Cancer | 2021 |
|
A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization
L Grunewald, T Lam, L Andersch, A Klaus, S Schwiebert, A Winkler, A Gauert, AI Heeren-Hagemann, K Astrahantseff, F Klironomos, A Thomas, HE Deubzer, AG Henssen, A Eggert, JH Schulte, K Anders, L Kloke, A Künkele |
Frontiers in immunology | 2021 |
|
Improving CAR T-Cell Persistence
V Pietrobon, LA Todd, A Goswami, O Stefanson, Z Yang, F Marincola |
International journal of molecular sciences | 2021 |
|
T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies
V Janelle, JS Delisle |
Cancers | 2021 |
|
A Correlation Between Differentiation Phenotypes of Infused T Cells and Anti-Cancer Immunotherapy
H Ren, K Cao, M Wang |
Frontiers in immunology | 2021 |
|
Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL
B Deng, J Pan, Z Liu, S Liu, Y Chen, X Qu, Y Zhang, Y Lin, Y Zhang, X Yu, Z Zhang, X Niu, R Luan, M Ma, X Li, T Liu, , H Niu, AH Chang, C Tong |
Molecular Therapy — Methods & Clinical Development | 2021 |
|
Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy
M Zhang, Z Zhao, Y Pritykin, M Hannum, AC Scott, F Kuo, V Sanghvi, TA Chan, V Seshan, HG Wendel, A Schietinger, M Sadelain, M Huse |
Science Translational Medicine | 2021 |
|
A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection
S Sharon, JR Baird, S Bambina, G Kramer, TC Blair, SM Jensen, RS Leidner, RB Bell, N Casap, MR Crittenden, MJ Gough |
Oncotarget | 2021 |
|
The Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients
M Arnaud, S Bobisse, J Chiffelle, A Harari |
Frontiers in immunology | 2021 |
|
A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains
KM Cappell, JN Kochenderfer |
Nature Reviews Clinical Oncology | 2021 |
|
Immunotherapy in Medulloblastoma: Current State of Research, Challenges, and Future Perspectives
MJ Voskamp, S Li, KR van Daalen, S Crnko, T ten Broeke, N Bovenschen |
Cancers | 2021 |
|
4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells
E Roselli, JC Boucher, G Li, H Kotani, K Spitler, K Reid, EV Cervantes, Y Bulliard, N Tu, SB Lee, B Yu, FL Locke, ML Davila |
Journal for ImmunoTherapy of Cancer | 2021 |
|
Engineered Cytokine Signaling to Improve CAR T Cell Effector Function
M Bell, S Gottschalk |
Frontiers in immunology | 2021 |
|
Promises and challenges of adoptive T-cell therapies for solid tumours
M Morotti, A Albukhari, A Alsaadi, M Artibani, JD Brenton, SM Curbishley, T Dong, ML Dustin, Z Hu, N McGranahan, ML Miller, L Santana-Gonzalez, LW Seymour, T Shi, PV Loo, C Yau, H White, N Wietek, DN Church, DC Wedge, AA Ahmed |
British Journal of Cancer | 2021 |
|
Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens
DE Jæhger, ML Hübbe, MK Kræmer, G Clergeaud, AV Olsen, C Stavnsbjerg, MN Wiinholt, A Kjær, JR Henriksen, AE Hansen, TL Andresen |
Scientific Reports | 2021 |
|
Generation of Pure Highly Functional Human Anti-Tumor Specific Cytotoxic T Lymphocytes With Stem Cell-Like Memory Features for Melanoma Immunotherapy
M Hamieh, JF Chatillon, E Dupel, F Bayeux, E Fauquembergue, P Maby, A Drouet, AB Duval-Modeste, S Adriouch, O Boyer, JB Latouche |
Frontiers in immunology | 2021 |
|
PI3K in T Cell Adhesion and Trafficking
KH Johansen, DP Golec, JH Thomsen, PL Schwartzberg, K Okkenhaug |
Frontiers in immunology | 2021 |
|
Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming
Y Wang, C Tong, H Dai, Z Wu, X Han, Y Guo, D Chen, J Wei, D Ti, Z Liu, Q Mei, X Li, L Dong, J Nie, Y Zhang, W Han |
Nature Communications | 2021 |
|
The role of small molecules in cell and gene therapy
LL Brayshaw, C Martinez-Fleites, T Athanasopoulos, T Southgate, L Jespers, C Herring |
2021 | |
|
Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells
MV Rosemblatt, B Parra-Tello, P Briceño, E Rivas-Yáñez, S Tucer, J Saavedra-Almarza, P Hörmann, BA Martínez, Á Lladser, M Rosemblatt, C Cekic, MR Bono, D Sauma |
Frontiers in Cell and Developmental Biology | 2021 |
|
Impacts of pembrolizumab therapy on immune phenotype in patients with high-grade neuroendocrine neoplasms
AW MacFarlane, HM Yeung, RK Alpaugh, E Dulaimi, PF Engstrom, A Dasari, KS Campbell, N Vijayvergia |
Cancer Immunology, Immunotherapy | 2021 |
|
Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications
VL Presti, AM Cornel, M Plantinga, E Dünnebach, J Kuball, JJ Boelens, S Nierkens, NP van Til |
Molecular Therapy — Methods & Clinical Development | 2021 |
|
Novel CAR T therapy is a ray of hope in the treatment of seriously ill AML patients
F Marofi, HS Rahman, ZM Al-Obaidi, AT Jalil, WK Abdelbasset, W Suksatan, AE Dorofeev, N Shomali, MS Chartrand, Y Pathak, A Hassanzadeh, B Baradaran, M Ahmadi, H Saeedi, S Tahmasebi, M Jarahian |
Stem Cell Research & Therapy | 2021 |
|
Combination Immunotherapy With LIGHT and Interleukin-2 Increases CD8 Central Memory T-Cells In Vivo
MF Fernandez, G Qiao, K Tulla, BS Prabhakar, AV Maker |
The Journal of surgical research | 2021 |
|
IL-15 Enhances the Persistence and Function of BCMA-Targeting CAR-T Cells Compared to IL-2 or IL-15/IL-7 by Limiting CAR-T Cell Dysfunction and Differentiation
AM Battram, M Bachiller, V Lopez, CF de Larrea, A Urbano-Ispizua, B Martín-Antonio |
Cancers | 2021 |
|
Epigenetic strategies to boost CAR T cell therapy
B Akbari, N Ghahri-Saremi, T Soltantoyeh, J Hadjati, S Ghassemi, HR Mirzaei |
Molecular Therapy | 2021 |
|
Immunotherapeutic Potential of T Memory Stem Cells
Y Li, D Wu, X Yang, S Zhou |
Frontiers in Oncology | 2021 |
|
The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma
D Duan, K Wang, C Wei, D Feng, Y Liu, Q He, X Xu, C Wang, S Zhao, L Lv, J Long, D Lin, A Zhao, B Fang, J Jiang, S Tang, J Gao |
Frontiers in immunology | 2021 |
|
Challenges and Clinical Strategies of CAR T-Cell Therapy for Acute Lymphoblastic Leukemia: Overview and Developments
X Xu, S Huang, X Xiao, Q Sun, X Liang, S Chen, Z Zhao, Z Huo, S Tu, Y Li |
Frontiers in immunology | 2021 |
|
Quantifying the limits of CAR T-cell delivery in mice and men
LV Brown, EA Gaffney, A Ager, J Wagg, MC Coles |
Journal of The Royal Society Interface | 2021 |
|
Characterization and Functional Analysis of CD44v6.CAR T Cells Endowed with a New Low-Affinity Nerve Growth Factor Receptor-Based Spacer
A Stornaiuolo, B Valentinis, C Sirini, C Scavullo, C Asperti, D Zhou, YM Torre, S Corna, M Casucci, S Porcellini, C Traversari |
Human Gene Therapy | 2021 |
|
IL-15-induced lymphocytes as adjuvant cellular immunotherapy for gastric cancer
Y Hu, D Liu, P Cui, W Zhang, H Chen, C Piao, Y Lu, X Liu, Y Wang, J Liu, X Lu |
Investigational New Drugs | 2021 |
|
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
S Bonte, S de Munter, L Billiet, G Goetgeluk, J Ingels, H Jansen, M Pille, L de Cock, K Weening, T Taghon, G Leclercq, B Vandekerckhove, T Kerre |
OncoImmunology | 2021 |
|
Memory stem T cells modified with a redesigned CD30‐chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma
C AlvarezFernández, L EscribàGarcia, AC Caballero, E EscuderoLópez, C UjaldónMiró, R MontserratTorres, P PujolFernández, J Sierra, J Briones |
IBMS BoneKEy | 2021 |
|
Accelerating clinical-scale production of BCMA CAR T cells with defined maturation stages.
Joedicke JJ, Großkinsky U, Gerlach K, Künkele A, Höpken UE, Rehm A |
2021 | |
|
Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL
Siddiqi T, Soumerai JD, Dorritie KA, Stephens DM, Riedell PA, Arnason J, Kipps TJ, Gillenwater HH, Gong L, Yang L, Ogasawara K, Thorpe J, Wierda WG |
Blood | 2021 |
|
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target
Stefano Pierini, Janos L. Tanyi, Fiona Simpkins, Erin George, Mireia Uribe-Herranz, Ronny Drapkin, Robert A Burger, Mark A Morgan, Andrea Facciabene |
JCI Insight | 2020 |
|
MyD88/CD40 signaling retains CAR T-cells in a less differentiated state
Brooke Prinzing, Patrick A. Schreiner, Matthew Bell, Yiping Fan, Giedre Krenciute, Stephen Gottschalk |
JCI Insight | 2020 |
|
A soluble activator that favors the ex-vivo expansion of CD8+CD27+ T-cells
Esther I Matus, Amanda Sparkes, Jean Gariépy |
JCI Insight | 2020 |
|
CX3CR1-CD8+ T cells are critical in antitumor efficacy, but functionally suppressed in the tumor microenvironment
Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Hidehito Saito, Kristopher Attwood, Michael S. Sabel, Alfred E. Chang, Kunle Odunsi, Fumito Ito |
JCI Insight | 2020 |
|
IL6 Fuels Durable Memory for Th17 Cell–Mediated Responses to Tumors
HM Knochelmann, CJ Dwyer, AS Smith, JS Bowers, MM Wyatt, MH Nelson, GO Rivera, JD Horton, C Krieg, K Armeson, GB Lesinski, MP Rubinstein, Z Li, CM Paulos |
Cancer research | 2020 |
|
Development of CAR-T cell therapy for B-ALL using a point-of-care approach
L de Macedo Abdo, LR Barros, MS Viegas, LV Marques, P de Sousa Ferreira, L Chicaybam, MH Bonamino |
OncoImmunology | 2020 |
|
Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction
A Gavriil, M Barisa, E Halliwell, J Anderson |
Cancers | 2020 |
|
Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy
T Mika, S Ladigan-Badura, A Maghnouj, B Mustafa, S Klein-Scory, A Baraniskin, S Döhring, I Fuchs, S Ehl, SA Hahn, R Schroers |
Frontiers in Oncology | 2020 |
|
Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8 + T cells
CJ Dwyer, DC Arhontoulis, GO Rivera, HM Knochelmann, AS Smith, MM Wyatt, MP Rubinstein, C Atkinson, JE Thaxton, DM Neskey, CM Paulos |
European Journal of Immunology | 2020 |
|
Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade
ML Hübbe, DE Jæhger, TL Andresen, MH Andersen |
Frontiers in immunology | 2020 |
|
TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals
F Manfredi, BC Cianciotti, A Potenza, E Tassi, M Noviello, A Biondi, F Ciceri, C Bonini, E Ruggiero |
Frontiers in immunology | 2020 |
|
Neoantigen-Specific Adoptive Cell Therapies for Cancer: Making T-Cell Products More Personal
V Bianchi, A Harari, G Coukos |
Frontiers in immunology | 2020 |
|
Targeting the epigenetic regulation of antitumour immunity
SJ Hogg, PA Beavis, MA Dawson, RW Johnstone |
Nature Reviews Drug Discovery | 2020 |
|
CAR T Cells Redirected to CD44v6 Control Tumor Growth in Lung and Ovary Adenocarcinoma Bearing Mice
S Porcellini, C Asperti, S Corna, E Cicoria, V Valtolina, A Stornaiuolo, B Valentinis, C Bordignon, C Traversari |
Frontiers in immunology | 2020 |
|
T cell factor 1: A master regulator of the T cell response in disease
G Escobar, D Mangani, AC Anderson |
Science Immunology | 2020 |
|
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression
E Lanitis, G Rota, P Kosti, C Ronet, A Spill, B Seijo, P Romero, D Dangaj, G Coukos, M Irving |
Journal of Experimental Medicine | 2020 |
|
TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product
T Straetemans, A Janssen, K Jansen, R Doorn, T Aarts, AD van Muyden, M Simonis, J Bergboer, M de Witte, Z Sebestyen, J Kuball |
Molecular Therapy | 2020 |
|
CAR-T design: Elements and their synergistic function
J Jayaraman, MP Mellody, AJ Hou, RP Desai, AW Fung, AH Pham, YY Chen, W Zhao |
EBioMedicine | 2020 |
|
Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies
R Mhaidly, E Verhoeyen |
Cancers | 2020 |
|
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings
MU Goruganthu, A Shanker, MM Dikov, DP Carbone |
Frontiers in immunology | 2020 |
|
Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting
L Sanz-Ortega, JM Rojas, DF Barber |
Pharmaceutics | 2020 |
|
Stem, Effector, and Hybrid States of Memory CD8+ T Cells
E Lugli, G Galletti, SK Boi, BA Youngblood |
Trends in Immunology | 2020 |
|
Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies
K Schober, TR Müller, DH Busch |
Cells | 2020 |
|
Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 chimeric antigen receptor in relapsed or refractory acute lymphoblastic leukemia
R Gu, F Liu, D Zou, Y Xu, Y Lu, B Liu, W Liu, X Chen, K Liu, Y Guo, X Gong, R Lv, X Chen, C Zhou, M Zhong, H Wang, H Wei, Y Mi, L Qiu, L Lv, M Wang, Y Wang, X Zhu, J Wang |
Journal of Hematology & Oncology | 2020 |
|
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
S Bonte, SD Munter, G Goetgeluk, J Ingels, M Pille, L Billiet, T Taghon, G Leclercq, B Vandekerckhove, T Kerre |
OncoImmunology | 2020 |
|
A modeling platform for the lymphatic system
J Ruiz-Ramírez, A Ziemys, P Dogra, M Ferrari |
Journal of Theoretical Biology | 2020 |
|
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells
T Oba, T Hoki, T Yamauchi, T Keler, HC Marsh, X Cao, F Ito |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
|
CD4 + T cells support polyfunctionality of cytotoxic CD8 + T cells with memory potential in immunological control of tumor
N Imai, I Tawara, M Yamane, D Muraoka, H Shiku, H Ikeda |
Cancer Science | 2020 |
|
Synergistic effects of low-dose chemotherapy and T cells in renal cell carcinoma
Xu DD, Ding M, Tong P, Chong YY, Gu WY, Li Y, Fang XJ, Li N |
Oncology reports | 2020 |
|
Phase I/II study protocol to assess safety and efficacy of adoptive cell therapy with anti-PD-1 plus low-dose pegylated-interferon-alpha in patients with metastatic melanoma refractory to standard of care treatments: the ACTME trial.
van der Kooij MK, Verdegaal EME, Visser M, de Bruin L, van der Minne CE, Meij PM, Roozen ICFM, Jonker MA, van den Bosch S, Liefers GJ, Speetjens FM, van der Burg SH, Kapiteijn E |
BMJ Open | 2020 |
|
Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors
Rebecca J Brownlie, David Wright, Rose Zamoyska, Robert J. Salmond |
JCI Insight | 2019 |
|
A Metabolism Toolbox for CAR T Therapy
X Xu, JN Gnanaprakasam, J Sherman, R Wang |
Frontiers in Oncology | 2019 |
|
Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy
S Stock, M Schmitt, L Sellner |
International journal of molecular sciences | 2019 |
|
Regulation of T cell antitumor immune response by tumor induced metabolic stress
F Chalmin, M Bruchard, F Vegran, F Ghiringhelli |
2019 | |
|
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
D Wang, R Starr, D Alizadeh, X Yang, SJ Forman, CE Brown |
Journal of visualized experiments : JoVE | 2019 |
|
Genetically engineered T cells for cancer immunotherapy
D Li, X Li, WL Zhou, Y Huang, X Liang, L Jiang, X Yang, J Sun, Z Li, WD Han, W Wang |
Signal Transduction and Targeted Therapy | 2019 |
|
Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency
O Bernadin, F Amirache, A Girard-Gagnepain, RD Moirangthem, C Lévy, K Ma, C Costa, D Nègre, C Reimann, D Fenard, A Cieslak, V Asnafi, H Sadek, R Mhaidly, M Cavazzana, C Lagresle-Peyrou, FL Cosset, I André, E Verhoeyen |
Blood Advances | 2019 |
|
Cell Reprogramming for Immunotherapy: Methods and Protocols
SG Katz, PM Rabinovich |
2019 | |
|
Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
H Läubli, L Borsig |
Frontiers in immunology | 2019 |
|
Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy
C Chen, FH Gao |
Frontiers in immunology | 2019 |
|
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
S Gautam, J Fioravanti, W Zhu, JB Gall, P Brohawn, NE Lacey, J Hu, JD Hocker, NV Hawk, V Kapoor, WG Telford, D Gurusamy, Z Yu, A Bhandoola, HH Xue, R Roychoudhuri, BW Higgs, NP Restifo, TP Bender, Y Ji, L Gattinoni |
Nature Immunology | 2019 |
|
Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy
SJ Patel, T Yamauchi, F Ito |
Surgical oncology clinics of North America | 2019 |
|
Switching on the green light for chimeric antigen receptor T-cell therapy
S Mardiana, J Lai, IG House, PA Beavis, PK Darcy |
IBMS BoneKEy | 2019 |
|
Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes
G Alatrash, N Qiao, M Zhang, M Zope, AA Perakis, P Sukhumalchandra, AV Philips, HR Garber, C Kerros, LS John, MR Khouri, H Khong, K Clise-Dwyer, LP Miller, S Wolpe, WW Overwijk, JJ Molldrem, Q Ma, EJ Shpall, EA Mittendorf |
Clinical cancer research | 2019 |
|
T cell immunotherapy enhanced by designer biomaterials
ZS Dunn, J Mac, P Wang |
Biomaterials | 2019 |
|
Induced Pluripotent Stem Cell (iPSC)–Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges
A Nianias, M Themeli |
Current Hematologic Malignancy Reports | 2019 |
|
L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy
HA Watson, RR Durairaj, J Ohme, M Alatsatianos, H Almutairi, RN Mohammed, M Vigar, SG Reed, SJ Paisey, C Marshall, A Gallimore, A Ager |
Frontiers in immunology | 2019 |
|
IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype
D Alizadeh, RA Wong, X Yang, D Wang, JR Pecoraro, CF Kuo, B Aguilar, Y Qi, DK Ann, R Starr, R Urak, X Wang, SJ Forman, CE Brown |
Cancer immunology research | 2019 |
|
Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells
PH Lee, TN Yamamoto, D Gurusamy, M Sukumar, Z Yu, J Hu-Li, T Kawabe, A Gangaplara, RJ Kishton, AN Henning, SK Vodnala, RN Germain, WE Paul, NP Restifo |
Journal of Experimental Medicine | 2019 |
|
To Bridge, Blossom, or Boost: That Is the Question
SM Arend, I Jedema |
Clinical Infectious Diseases | 2019 |
|
Overcoming Challenges in Process Development of Cellular Therapies
SL Highfill, DF Stroncek |
Current Hematologic Malignancy Reports | 2019 |
|
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
J Wei, L Long, W Zheng, Y Dhungana, SA Lim, C Guy, Y Wang, YD Wang, C Qian, B Xu, A KC, J Saravia, H Huang, J Yu, JG Doench, TL Geiger, H Chi |
Nature | 2019 |
|
In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy
F Ito, TD Vardam, MM Appenheimer, KH Eng, SO Gollnick, JB Muhitch, SS Evans |
International Journal of Hyperthermia | 2019 |
|
Glioblastoma-Targeted CD4+ CAR-T cells outperform CD8+ cells for Sustained Effector Function and Superior Antitumor Activity
Dongrui Wang, Brenda Aguilar, Renate Starr, Darya Alizadeh, Alfonso Brito, Aniee Sarkissian, Julie Ostberg, Stephen J. Forman, Christine Brown |
JCI Insight | 2018 |
|
Antioxidant metabolism regulates CD8+ T memory stem cell formation and anti-tumor immunity
Karolina Pilipow, Eloise Scamardella, Simone Puccio, Sanjivan Gautam, Federica De Paoli, Emilia Maria Cristina Mazza, Gabriele De Simone, Sara Polletti, Marta Buccilli, Veronica Zanon, Pietro Di Lucia, Matteo Iannacone, Luca Gattinoni, Enrico Lugli |
JCI Insight | 2018 |
|
Redirection to the bone marrow improves T cell persistence and anti-tumor functions
Anjum B. Khan, Ben Carpenter, Pedro Santos e Sousa, Constandina Pospori, Reema Khorshed, James Griffin, Pedro Veliça, Mathias Zech, Sara Ghorashian, Calum Forrest, Sharyn Thomas, Sara Gonzalez Anton, Maryam Ahmadi, Angelika Holler, Barry Flutter, Zaida Ramirez-Ortiz, Terry K Means, Clare L Bennett, Hans Stauss, Emma Morris, Cristina Lo Celso, Ronjon Chakraverty |
Journal of Clinical Investigation | 2018 |
|
Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells
AF Kirkin, KN Dzhandzhugazyan, P Guldberg, JJ Fang, RS Andersen, C Dahl, J Mortensen, T Lundby, A Wagner, I Law, H Broholm, L Madsen, C Lundell-Ek, MF Gjerstorff, HJ Ditzel, MR Jensen, W Fischer |
Nature Communications | 2018 |
|
Cholesterol negatively regulates IL-9–producing CD8 + T cell differentiation and antitumor activity
X Ma, E Bi, C Huang, Y Lu, G Xue, X Guo, A Wang, M Yang, J Qian, C Dong, Q Yi |
Journal of Experimental Medicine | 2018 |
|
IL-21 receptor signaling is essential for control of hepatocellular carcinoma growth and immunological memory for tumor challenge
X Zheng, Y Zhou, X Yi, C Chen, C Wen, G Ye, X Li, L Tang, X Zhang, F Yang, G Liu, Y Li, J Hou |
OncoImmunology | 2018 |
|
Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses
F Hossain, S Majumder, DA Ucar, PC Rodriguez, TE Golde, LM Minter, BA Osborne, L Miele |
Frontiers in immunology | 2018 |
|
Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model
A Contreras, MV Beems, AJ Tatar, S Sen, P Srinand, M Suresh, TK Luther, CS Cho |
Journal for ImmunoTherapy of Cancer | 2018 |
|
Epigenetic control of CD8+ T cell differentiation
AN Henning, R Roychoudhuri, NP Restifo |
Nature Reviews Immunology | 2018 |
|
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies
HM Knochelmann, AS Smith, CJ Dwyer, MM Wyatt, S Mehrotra, CM Paulos |
Frontiers in immunology | 2018 |
|
Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8 + T cells for adoptive immunotherapy
CM Mousset, W Hobo, Y Ji, H Fredrix, VD Giorgi, RD Allison, MG Kester, JH Falkenburg, NP Schaap, JH Jansen, L Gattinoni, H Dolstra, AB van der Waart |
OncoImmunology | 2018 |
|
When worlds collide: Th17 and Treg cells in cancer and autoimmunity
HM Knochelmann, CJ Dwyer, SR Bailey, SM Amaya, DM Elston, JM Mazza-McCrann, CM Paulos |
Cellular and Molecular Immunology | 2018 |
|
Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells
AS Cheung, DK Zhang, ST Koshy, DJ Mooney |
Nature Biotechnology | 2018 |
|
Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach
AM Krackhardt, B Anliker, M Hildebrandt, M Bachmann, SB Eichmüller, DM Nettelbeck, M Renner, L Uharek, G Willimsky, M Schmitt, WS Wels, M Schüssler-Lenz |
Cancer Immunology, Immunotherapy | 2018 |
|
IL-21 Selectively Protects CD62L + NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
H Ngai, G Tian, AN Courtney, SB Ravari, L Guo, B Liu, J Jin, ET Shen, EJ Pierro, LS Metelitsa |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
|
Selectins in cancer immunity
L Borsig |
Glycobiology | 2018 |
|
Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency
JM Carpier, CL Lucas |
Frontiers in immunology | 2018 |
|
Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System
R Vizcardo, ND Klemen, SM Islam, D Gurusamy, N Tamaoki, D Yamada, H Koseki, BL Kidder, Z Yu, L Jia, AN Henning, ML Good, M Bosch-Marce, T Maeda, C Liu, Z Abdullaev, S Pack, DC Palmer, DF Stroncek, F Ito, FA Flomerfelt, MJ Kruhlak, NP Restifo |
Cell Reports | 2018 |
|
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells
A Wenger, K Werlenius, A Hallner, FB Thorén, D Farahmand, M Tisell, A Smits, B Rydenhag, AS Jakola, H Carén |
Neoplasia (New York, N.Y.) | 2018 |
|
Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions:
SY Lee, P Olsen, DH Lee, AL Kenoyer, LE Budde, S OSteen, DJ Green, S Heimfeld, MC Jensen, SR Riddell, OW Press, BG Till |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2018 |
|
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
JA Fraietta, SF Lacey, EJ Orlando, I Pruteanu-Malinici, M Gohil, S Lundh, AC Boesteanu, Y Wang, RS OConnor, WT Hwang, E Pequignot, DE Ambrose, C Zhang, N Wilcox, F Bedoya, C Dorfmeier, F Chen, L Tian, H Parakandi, M Gupta, RM Young, FB Johnson, I Kulikovskaya, L Liu, J Xu, SH Kassim, MM Davis, BL Levine, NV Frey, DL Siegel, AC Huang, EJ Wherry, H Bitter, JL Brogdon, DL Porter, CH June, JJ Melenhorst |
Nature Medicine | 2018 |
|
Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1c259T cells in Synovial Sarcoma
SP D'Angelo, L Melchiori, MS Merchant, DB Bernstein, J Glod, RN Kaplan, SA Grupp, WD Tap, K Chagin, GK Binder, S Basu, DE Lowther, R Wang, N Bath, A Tipping, G Betts, I Ramachandran, JM Navenot, H Zhang, DK Wells, EV Winkle, G Kari, T Trivedi, T Holdich, LN Pandite, R Amado, CL Mackall |
Cancer Discovery | 2018 |
|
Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors
Y Lu, Q Wang, G Xue, E Bi, X Ma, A Wang, J Qian, C Dong, Q Yi |
Cancer Cell | 2018 |
|
Design considerations for early-phase clinical trials of immune-oncology agents
NA Wages, C Chiuzan, KS Panageas |
Journal for ImmunoTherapy of Cancer | 2018 |
|
An Adaptive Dose-Finding Design Based on Both Safety and Immunologic Responses in Cancer Clinical Trials
C Chiuzan, E Garrett-Mayer, MI Nishimura |
Statistics in Biopharmaceutical Research | 2018 |
|
A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication
J Zhou, MT Bethune, N Malkova, AM Sutherland, B Comin-Anduix, Y Su, D Baltimore, A Ribas, JR Heath, IM Svane |
PloS one | 2018 |
|
N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner
MJ Scheffel, G Scurti, MM Wyatt, E Garrett-Mayer, CM Paulos, MI Nishimura, C Voelkel-Johnson |
Cancer Immunology, Immunotherapy | 2018 |
|
An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells
NA Lieberman, K DeGolier, K Haberthur, H Chinn, KW Moyes, MN Bouchlaka, KL Walker, CM Capitini, CA Crane |
Frontiers in immunology | 2018 |
|
Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy
T Kondo, Y Imura, S Chikuma, S Hibino, S Omata-Mise, M Ando, T Akanuma, M Iizuka, R Sakai, R Morita, A Yoshimura |
Cancer Science | 2018 |
|
Melanoma treatment in review
B Domingues, J Lopes, P Soares, H Populo |
ImmunoTargets and Therapy | 2018 |
|
High-dimensional single cell analysis identifies stem-like cytotoxic CD8 + T cells infiltrating human tumors
J Brummelman, EM Mazza, G Alvisi, FS Colombo, A Grilli, J Mikulak, D Mavilio, M Alloisio, F Ferrari, E Lopci, P Novellis, G Veronesi, E Lugli |
Journal of Experimental Medicine | 2018 |
|
Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function
Rod A Rahimi, Andrew D Luster |
Advances in immunology | 2018 |
|
Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity
A Molodtsov, MJ Turk |
Frontiers in immunology | 2018 |
|
Specific Adoptive T-Cell Therapy for Viral and Fungal Infections
Lum LG, Bollard CM |
2018 | |
|
Immunotherapy for transplantation-associated infections (CMV/EBV-specific T cells)
Claire Roddie, Karl Peggs |
Journal of Clinical Investigation | 2017 |
|
Th17 cells are refractory to senescence retaining robust antitumor activity after long-term ex vivo expansion
Jacob Bowers, Michelle H. Nelson, Kinga Majchrzak, Stefanie Bailey, Barbel Rohrer, Andrew Kaiser, Carl Atkinson, Luca Gattinoni, Chrystal Paulos |
JCI Insight | 2017 |
|
Pharmacologic inhibition of β-catenin and PI3Kδ paradoxically expands precursor Th17 cells with heightened stemness and antitumor activity
Kinga Majchrzak, Michelle H. Nelson, Jacob Bowers, Stefanie Bailey, Megan Meek, John Wrangle, Juan Varela, Mark Rubinstein, zihai Li, Richard Himes, Sherine Chan, Chrystal Paulos |
JCI Insight | 2017 |
|
Inhibition of AKT-signaling uncouples T-cell differentiation from expansion for receptor-engineered adoptive immunotherapy
Christopher Klebanoff, Joseph G. Crompton, Anthony Leonardi, Tori Yamamoto, Smita Chandran, Robert Eil, Madhusudhanan Sukumar, Suman Kumar Vodnala, Jinhui Hu, Yun Ji, David Clever, Mary Black, Devikala Gurusamy, Michael Kruhlak, Ping Jin, David Stroncek, Luca Gattinoni, Steven A. Feldman, Nicholas Restifo |
JCI Insight | 2017 |
|
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40
DJ Messenheimer, SM Jensen, ME Afentoulis, KW Wegmann, Z Feng, DJ Friedman, MJ Gough, WJ Urba, BA Fox |
Clinical cancer research | 2017 |
|
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
RJ Kishton, M Sukumar, NP Restifo |
Cell Metabolism | 2017 |
|
Trial Watch: Adoptively transferred cells for anticancer immunotherapy
C Fournier, F Martin, L Zitvogel, G Kroemer, L Galluzzi, L Apetoh |
OncoImmunology | 2017 |
|
PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells
JS Bowers, K Majchrzak, MH Nelson, BA Aksoy, MM Wyatt, AS Smith, SR Bailey, LR Neal, JE Hammerbacher, CM Paulos |
Frontiers in immunology | 2017 |
|
Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
JG Crompton, N Klemen, US Kammula |
Annals of Surgical Oncology | 2017 |
|
Modulation of CD8 + memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer
J Zhang, Y Zhao, Y Lv, P Cheng, W Chen, M Duan, Y Teng, T Wang, L Peng, F Mao, Y Liu, X Fu, P Yu, P Luo, W Zhang, Q Zou, Y Zhuang |
OncoImmunology | 2017 |
|
T memory stem cells in health and disease
L Gattinoni, DE Speiser, M Lichterfeld, C Bonini |
Nature Medicine | 2017 |
|
Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy
T Kondo, R Morita, Y Okuzono, H Nakatsukasa, T Sekiya, S Chikuma, T Shichita, M Kanamori, M Kubo, K Koga, T Miyazaki, Y Kassai, A Yoshimura |
Nature Communications | 2017 |
|
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective
I Rivière, M Sadelain |
Molecular Therapy | 2017 |
|
Therapeutic T cell engineering
M Sadelain, I Rivière, S Riddell |
Nature | 2017 |
|
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel
M Irving, RV de Silly, K Scholten, N Dilek, G Coukos |
Frontiers in immunology | 2017 |
|
Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
SA Shah, M Zarei, SH Manjili, G Guruli, XY Wang, MH Manjili |
Immunotherapy | 2017 |
|
Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation
MH Nada, H Wang, G Workalemahu, Y Tanaka, CT Morita |
Journal for ImmunoTherapy of Cancer | 2017 |
|
Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells
JM Gammon, EA Gosselin, LH Tostanoski, YC Chiu, X Zeng, Q Zeng, CM Jewell |
Journal of Controlled Release | 2017 |
|
Expansion of T Cells with Interleukin-21 for Adoptive Immunotherapy of Murine Mammary Carcinoma
C Zoon, W Wan, L Graham, H Bear |
International journal of molecular sciences | 2017 |
|
CCR7+ selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo
G Kueberuwa, H Gornall, EM Alcantar-Orozco, D Bouvier, ZA Kapacee, RE Hawkins, DE Gilham |
Journal for ImmunoTherapy of Cancer | 2017 |
|
Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy
R Urak, M Walter, L Lim, CL Wong, LE Budde, S Thomas, SJ Forman, X Wang |
Journal for ImmunoTherapy of Cancer | 2017 |
|
T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy
R Sackstein, T Schatton, SR Barthel |
Laboratory Investigation | 2017 |
|
Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids
CS Seet, C He, MT Bethune, S Li, B Chick, EH Gschweng, Y Zhu, K Kim, DB Kohn, D Baltimore, GM Crooks, A Montel-Hagen |
Nature Methods | 2017 |
|
Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir
JL Riley, LJ Montaner |
The Journal of Infectious Diseases | 2017 |
|
Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation
X Liu, S Jiang, C Fang, H Li, X Zhang, F Zhang, CH June, Y Zhao |
Protein & Cell | 2017 |
|
In Vivo Murine-Matured Human CD3 + Cells as a Preclinical Model for T Cell-Based Immunotherapies
KG Haworth, C Ironside, ZK Norgaard, WM Obenza, JE Adair, HP Kiem |
Molecular Therapy - Methods & Clinical Development | 2017 |
|
Tracking the fate and origin of clinically relevant adoptively transferred CD8 + T cells in vivo
AG Chapuis, C Desmarais, R Emerson, TM Schmitt, KC Shibuya, IP Lai, F Wagener, J Chou, IM Roberts, DG Coffey, EH Warren, H Robins, PD Greenberg, C Yee |
Science Immunology | 2017 |
|
Curtailed T-cell activation curbs effector differentiation and generates CD8 + T cells with a naturally-occurring memory stem cell phenotype
V Zanon, K Pilipow, E Scamardella, FD Paoli, GD Simone, DA Price, AM Usatorre, P Romero, D Mavilio, A Roberto, E Lugli |
European Journal of Immunology | 2017 |
|
Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo
A Kirschner, M Thiede, TG Grünewald, RA Rubio, GH Richter, T Kirchner, DH Busch, S Burdach, U Thiel |
OncoImmunology | 2017 |
|
An Archaeosome-Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Significantly Enhances Protection from Murine Melanoma
F Stark, R Weeratna, L Deschatelets, K Gurnani, R Dudani, M McCluskie, L Krishnan |
Human vaccines | 2017 |
|
Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence
SR Bailey, MH Nelson, K Majchrzak, JS Bowers, MM Wyatt, AS Smith, LR Neal, K Shirai, C Carpenito, CH June, MJ Zilliox, CM Paulos |
Nature Communications | 2017 |
|
Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer
HJ Lee, YA Kim, CK Sim, SH Heo, IH Song, HS Park, SY Park, WS Bang, IA Park, M Lee, JH Lee, YS Cho, S Chang, J Jung, J Kim, SB Lee, SY Kim, MS Lee, G Gong |
Oncotarget | 2017 |
|
BET bromodomain inhibition generates superior T cells for adoptive immunotherapy
Yuki Kagoya, Munehide Nakatsugawa, Yuki Yamashita, Toshiki Ochi, Tingxi Guo, Mark Anczurowski, Kayoko Saso, Marcus Butler, Cheryl Arrowsmith, Naoto Hirano |
Journal of Clinical Investigation | 2016 |
|
CD62L+ NKT cells have superior in vivo persistence and anti-tumor activity
Gengwen Tian, Amy N. Courtney, Bipulendu Jena, Andras Heczey, Daofeng Liu, Ekaterina Marinova, Linjie Guo, Xin Xu, Hiroki Torikai, Qianxing Mo, Gianpietro Dotti, Laurence Cooper, Leonid Metelitsa |
Journal of Clinical Investigation | 2016 |
|
Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
M Sabatino, J Hu, M Sommariva, S Gautam, V Fellowes, JD Hocker, S Dougherty, H Qin, CA Klebanoff, TJ Fry, RE Gress, JN Kochenderfer, DF Stroncek, Y Ji, L Gattinoni |
Blood | 2016 |
|
Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
DC Deniger, A Pasetto, E Tran, MR Parkhurst, CJ Cohen, PF Robbins, LJ Cooper, SA Rosenberg |
Molecular Therapy | 2016 |
|
Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression
Y Zhang, HC Ertl |
Frontiers in immunology | 2016 |
|
Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets
D Moogk, S Zhong, Z Yu, I Liadi, W Rittase, V Fang, J Dougherty, A Perez-Garcia, I Osman, C Zhu, N Varadarajan, NP Restifo, AB Frey, M Krogsgaard |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
|
Effector, Memory, and Dysfunctional CD8 + T Cell Fates in the Antitumor Immune Response
J Reiser, A Banerjee |
Journal of Immunology Research | 2016 |
|
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report
J Gea-Banacloche, KV Komanduri, P Carpenter, S Paczesny, S Sarantopoulos, JA Young, NE Kassar, RQ Le, KR Schultz, LM Griffith, BN Savani, JR Wingard |
Biology of Blood and Marrow Transplantation | 2016 |
|
Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells
H Saito, K Okita, N Fusaki, MS Sabel, AE Chang, F Ito |
Stem Cells International | 2016 |
|
Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells
M Haque, J Song, K Fino, P Sandhu, Y Wang, B Ni, D Fang, J Song |
Cell Transplantation | 2016 |
|
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic
K Majchrzak, MH Nelson, SR Bailey, JS Bowers, XZ Yu, MP Rubinstein, RA Himes, CM Paulos |
Cancer Immunology, Immunotherapy | 2016 |
|
Enhancing adoptive T cell immunotherapy with microRNA therapeutics
Y Ji, JD Hocker, L Gattinoni |
Seminars in Immunology | 2016 |
|
Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma
RE Cooke, NA Gherardin, SJ Harrison, H Quach, DI Godfrey, M Prince, R Koldej, DS Ritchie |
Journal of Translational Medicine | 2016 |
|
Conditions for the generation of cytotoxic CD4+ Th cells that enhance CD8+ CTL-mediated tumor regression
K Li, M Baird, J Yang, C Jackson, F Ronchese, S Young |
IBMS BoneKEy | 2016 |
|
The Distribution of Human Stem Cell–like Memory T Cell in Lung Cancer:
H Hong, Y Gu, SY Sheng, CG Lu, JY Zou, CY Wu |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2016 |
|
Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion
SD Four, SK Maenhout, D Benteyn, BD Keersmaecker, J Duerinck, K Thielemans, B Neyns, JL Aerts |
Cancer Immunology, Immunotherapy | 2016 |
|
Prime pick: Researchers get selective about T cells for cancer therapy
S Chakradhar |
Nature Medicine | 2016 |
|
Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice
X Liu, DM Barrett, S Jiang, C Fang, M Kalos, SA Grupp, CH June, Y Zhao |
Blood Cancer Journal | 2016 |
|
Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice
A Contreras, S Sen, AJ Tatar, DA Mahvi, JV Meyers, P Srinand, M Suresh, CS Cho |
Cancer Immunology, Immunotherapy | 2016 |
|
Chimeric antigen receptor-redirected T cells return to the bench
C Geldres, B Savoldo, G Dotti |
Seminars in Immunology | 2016 |
|
T cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy
PL Raber, RA Sierra, PT Thevenot, Z Shuzhong, DD Wyczechowska, T Kumai, E Celis, PC Rodriguez |
Oncotarget | 2016 |
|
Improving the clinical impact of biomaterials in cancer immunotherapy
JM Gammon, NM Dold, CM Jewell |
Oncotarget | 2016 |
|
Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death
MJ Scheffel, G Scurti, P Simms, E Garrett-Mayer, S Mehrotra, MI Nishimura, C Voelkel-Johnson |
Cancer research | 2016 |
|
Soluble and membrane-bound interleukin (IL)-15 R α /IL-15 complexes mediate proliferation of high-avidity central memory CD8 + T cells for adoptive immunotherapy of cancer and infections: IL-15Rα/IL-15 & memory T cell avidity
AN Hasan, A Selvakumar, E Shabrova, XR Liu, F Afridi, G Heller, I Riviere, M Sadelain, B Dupont, RJ O'Reilly |
Clinical & Experimental Immunology | 2016 |
|
Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes
AW Ku, JB Muhitch, CA Powers, M Diehl, M Kim, DT Fisher, AP Sharda, VK Clements, K O'Loughlin, H Minderman, MN Messmer, J Ma, JJ Skitzki, DA Steeber, B Walcheck, S Ostrand-Rosenberg, SI Abrams, SS Evans |
eLife | 2016 |
|
T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients
Y Klaver, SC van Steenbergen, S Sleijfer, R Debets, CH Lamers |
Frontiers in immunology | 2016 |
|
Hypoxia and antitumor CD8 + T cells: An incompatible alliance?
RV de Silly, PY Dietrich, PR Walker |
OncoImmunology | 2016 |
|
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca 2+ signalling and granule mobilization
M Frick, P Mouchacca, G Verdeil, Y Hamon, C Billaudeau, M Buferne, M Fallet, N Auphan-Anezin, AM Schmitt-Verhulst, C Boyer |
Immunology | 2016 |
|
The modulation of Dicer regulates tumor immunogenicity in melanoma
NC Hoffend, WJ Magner, TB Tomasi |
Oncotarget | 2016 |
|
Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells
A Ager, HA Watson, SC Wehenkel, RN Mohammed |
Biochemical Society Transactions | 2016 |
|
抗CD19嵌合抗原受体修饰的T细胞在血液系统恶性肿瘤中的应用
|
2016 | |
|
Selection bias: maintaining less differentiated T cells for adoptive immunotherapy
Yang Xu, Gianpietro Dotti |
Journal of Clinical Investigation | 2015 |
|
Quorum-like behavior between T-cell subsets enhances differentiation impairing cellular immunotherapy
Christopher A. Klebanoff, Christopher Scott, Anthony Leonardi, Tori Yamamoto, Anthony Cruz, Claudia Ouyang, Madhu Ramaswamy, Rahul Roychoudhuri, Yun Ji, Robert Eil, Madhusudhanan Sukumar, Joseph G. Crompton, Douglas C. Palmer, Zachary Borman, David Clever, Stacy K. Thomas, Shashank Patel, Zhiya Yu, Pawel Muranski, Hui Liu, Ena Wang, Francesco Marincola, Alena Gros, Luca Gattinoni, Steven Rosenberg, Richard Siegel, Nicholas Restifo |
Journal of Clinical Investigation | 2015 |
|
T-cell receptor gene therapy - ready to go viral?
T Karpanen, J Olweus |
Molecular Oncology | 2015 |
|
Targeting T cell metabolism for therapy
D O'Sullivan, EL Pearce |
Trends in Immunology | 2015 |
|
Harnessing the Microbiome to Enhance Cancer Immunotherapy
MH Nelson, MA Diven, LW Huff, CM Paulos |
Journal of Immunology Research | 2015 |
|
Metabolic regulation of T cell differentiation and function
BV Park, F Pan |
Molecular Immunology | 2015 |
|
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement
C Smith, G Økern, S Rehan, L Beagley, SK Lee, T Aarvak, KW Schjetne, R Khanna |
IBMS BoneKEy | 2015 |
|
Towards a commercial process for the manufacture of genetically modified T cells for therapy
AD Kaiser, M Assenmacher, B Schröder, M Meyer, R Orentas, U Bethke, B Dropulic |
Cancer Gene Therapy | 2015 |
|
Adoptive cell transfer as personalized immunotherapy for human cancer
SA Rosenberg, NP Restifo |
Science | 2015 |
|
Genetically modified T cells in cancer therapy: opportunities and challenges
M Sharpe, N Mount |
Disease models & mechanisms | 2015 |
|
Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture
V Janelle, C Carli, J Taillefer, J Orio, JS Delisle |
Journal of Translational Medicine | 2015 |
|
Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL
Y Cui, M Onozawa, HR Garber, L Samsel, Z Wang, JP McCoy, S Burkett, X Wu, PD Aplan, CL Mackall |
Blood | 2015 |
|
Addition of Interleukin-21 for Expansion of T-Cells for Adoptive Immunotherapy of Murine Melanoma
C Zoon, W Wan, L Graham, H Bear |
International journal of molecular sciences | 2015 |
|
Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B
M Grange, M Giordano, A Mas, R Roncagalli, G Firaguay, JA Nunes, J Ghysdael, AM Schmitt-Verhulst, N Auphan-Anezin |
Immunology | 2015 |
|
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules
AB Rodriguez-Peña, J Gomez-Rodriguez, RL Kortum, DC Palmer, Z Yu, GC Guittard, EA Wohlfert, PB Silver, JA Misplon, CL Sommers, L Feigenbaum, SL Epstein, RR Caspi, Y Belkaid, NP Restifo, LE Samelson, L Balagopalan |
Gene Therapy | 2015 |
|
Consensus nomenclature for CD8 + T cell phenotypes in cancer
L Apetoh, MJ Smyth, CG Drake, JP Abastado, RN Apte, M Ayyoub, JY Blay, M Bonneville, LH Butterfield, A Caignard, C Castelli, F Cavallo, E Celis, L Chen, MP Colombo, B Comin-Anduix, G Coukos, MV Dhodapkar, G Dranoff, IH Frazer, WH Fridman, DI Gabrilovich, E Gilboa, S Gnjatic, D Jäger, P Kalinski, HL Kaufman, R Kiessling, J Kirkwood, A Knuth, R Liblau, MT Lotze, E Lugli, F Marincola, I Melero, CJ Melief, TR Mempel, EA Mittendorf, K Odun, WW Overwijk, AK Palucka, G Parmiani, A Ribas, P Romero, RD Schreiber, G Schuler, PK Srivastava, E Tartour, D Valmori, SH van der Burg, P der Bruggen, BJ van Eynde, E Wang, W Zou, TL Whiteside, DE Speiser, DM Pardoll, NP Restifo, AC Anderson |
OncoImmunology | 2015 |
|
Synthetic biology in cell-based cancer immunotherapy
D Chakravarti, WW Wong |
Trends in Biotechnology | 2015 |
|
Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations
DC Deniger, J Yu, MH Huls, MJ Figliola, T Mi, SN Maiti, GF Widhopf, LV Hurton, R Thokala, H Singh, S Olivares, RE Champlin, WG Wierda, TJ Kipps, LJ Cooper, D Unutmaz |
PloS one | 2015 |
|
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma
Y Zheng, G Parsonage, X Zhuang, LR Machado, CH James, A Salman, PF Searle, EP Hui, AT Chan, SP Lee |
Cancer immunology research | 2015 |
|
Tumor-Specific Effector CD8+ T Cells That Can Establish Immunological Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7 Receptor and c-myc
SS Chandran, BC Paria, AK Srivastava, LD Rothermel, DJ Stephens, US Kammula |
Cancer research | 2015 |
|
Survivin targeted immunotherapy drives robust polyfunctional T cell generation and differentiation in advanced ovarian cancer patients
NL Berinstein, M Karkada, AM Oza, K Odunsi, JA Villella, JJ Nemunaitis, MA Morse, T Pejovic, J Bentley, M Buyse, R Nigam, GM Weir, LD MacDonald, T Quinton, R Rajagopalan, K Sharp, A Penwell, L Sammatur, T Burzykowski, MM Stanford, M Mansour |
OncoImmunology | 2015 |
|
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells
F Flores-Santibáñez, D Fernández, D Meza, G Tejón, L Vargas, L Varela-Nallar, S Arredondo, V Guixé, M Rosemblatt, MR Bono, D Sauma |
Immunology | 2015 |
|
Comparison of Naïve and Central Memory Derived CD8 + Effector Cell Engraftment Fitness and Function Following Adoptive Transfer
X Wang, CL Wong, R Urak, E Taus, B Aguilar, WC Chang, A Mardiros, LE Budde, CE Brown, C Berger, SJ Forman, MC Jensen |
OncoImmunology | 2015 |
|
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab
J Bjoern, NJ Nitschke, TZ Iversen, H Schmidt, K Fode, IM Svane |
OncoImmunology | 2015 |
|
The memory of a killer T cell: models of CD8+ T cell differentiation
B Gerritsen, A Pandit |
Immunology and Cell Biology | 2015 |
|
Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions
P Kesarwani, AA Al-Khami, G Scurti, K Thyagarajan, N Kaur, S Husain, Q Fang, OS Naga, P Simms, G Beeson, C Voelkel-Johnson, E Garrett-Mayer, CC Beeson, MI Nishimura, S Mehrotra |
Cancer research | 2014 |
|
Th17 Cells in Cancer: The Ultimate Identity Crisis
SR Bailey, MH Nelson, RA Himes, Z Li, S Mehrotra, CM Paulos |
Frontiers in immunology | 2014 |
|
Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy
DM Barrett, N Singh, X Liu, S Jiang, CH June, SA Grupp, Y Zhao |
Cytotherapy | 2014 |
|
Interleukin-21: a double-edged sword with therapeutic potential
R Spolski, WJ Leonard |
Nature Reviews Drug Discovery | 2014 |
|
Rise of iPSCs as a cell source for adoptive immunotherapy
A Minagawa, S Kaneko |
Human Cell | 2014 |
|
Allogeneic lymphocyte-licensed DCs expand T cells with improved antitumor activity and resistance to oxidative stress and immunosuppressive factors
C Jin, D Yu, V Hillerdal, AC Wallgren, A Karlsson-Parra, M Essand |
Molecular Therapy — Methods & Clinical Development | 2014 |
|
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
Y Lu, B Hong, H Li, Y Zheng, M Zhang, S Wang, J Qian, Q Yi |
Proceedings of the National Academy of Sciences | 2014 |
|
Reprogramming antitumor immunity
JG Crompton, D Clever, R Vizcardo, M Rao, NP Restifo |
Trends in Immunology | 2014 |
|
Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT
L Li, HT Kim, A Nellore, N Patsoukis, V Petkova, S McDonough, I Politikos, S Nikiforow, R Soiffer, JH Antin, K Ballen, C Cutler, J Ritz, VA Boussiotis |
Blood Cancer Journal | 2014 |
|
Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders
S Linnerbauer, U Behrends, D Adhikary, K Witter, GW Bornkamm, J Mautner |
PLoS pathogens | 2014 |
|
Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing
Y Ji, N Abrams, W Zhu, E Salinas, Z Yu, DC Palmer, P Jailwala, Z Franco, R Roychoudhuri, E Stahlberg, L Gattinoni, NP Restifo |
PloS one | 2014 |
|
Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer
T Ishikawa, S Kokura, T Enoki, N Sakamoto, T Okayama, M Ideno, J Mineno, K Uno, N Yoshida, K Kamada, K Katada, K Uchiyama, O Handa, T Takagi, H Konishi, N Yagi, Y Naito, Y Itoh, T Yoshikawa |
PloS one | 2014 |
|
Cell-based strategies to manage leukemia relapse: efficacy and feasibility of immunotherapy approaches
A Rambaldi, E Biagi, C Bonini, A Biondi, M Introna |
Leukemia | 2014 |
|
T Cell Receptor-Engineered T Cells to Treat Solid Tumors: T Cell Processing Toward Optimal T Cell Fitness
CH Lamers, S Steenbergen-Langeveld, M Brakel, CM Ruijven, PM van Elzakker, B Krimpen, S Sleijfer, R Debets |
Human Gene Therapy Methods | 2014 |
|
CMV-specific T cell isolation from G-CSF mobilized peripheral blood: depletion of myeloid progenitors eliminates non-specific binding of MHC-multimers
L Beloki, M Ciaurriz, C Mansilla, A Zabalza, E Perez-Valderrama, ER Samuel, MW Lowdell, N Ramirez, E Olavarria |
Journal of Translational Medicine | 2014 |
|
MicroRNA regulation in human CD8+ T cell subsets – cytokine exposure alone drives miR-146a expression
HM Sheppard, D Verdon, A Brooks, V Feisst, YY Ho, N Lorenz, V Fan, NP Birch, A Didsbury, P Dunbar |
Journal of Translational Medicine | 2014 |
|
A comparison between cytokine- and bead-stimulated polyclonal T cells: the superiority of each and their possible complementary role
WC Chan, YC Linn |
Cytotechnology | 2014 |
|
Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells
J Bae, M Samur, A Munshi, T Hideshima, D Keskin, A Kimmelman, AH Lee, G Dranoff, KC Anderson, NC Munshi |
OncoImmunology | 2014 |
|
Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans
SS Chandran, BC Paria, AK Srivastava, LD Rothermel, DJ Stephens, ME Dudley, R Somerville, JR Wunderlich, RM Sherry, JC Yang, SA Rosenberg, US Kammula |
Clinical cancer research | 2014 |
|
HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
EH Gschweng, MN McCracken, ML Kaufman, M Ho, RP Hollis, X Wang, N Saini, RC Koya, T Chodon, A Ribas, ON Witte, DB Kohn |
Cancer research | 2014 |
|
Antigen-Specific Culture of Memory-like CD8 T Cells for Adoptive Immunotherapy
AJ Litterman, DM Zellmer, RS LaRue, SC Jameson, DA Largaespada |
Cancer immunology research | 2014 |
|
Whole-Body Irradiation Increases the Magnitude and Persistence of Adoptively Transferred T Cells Associated with Tumor Regression in a Mouse Model of Prostate Cancer
LK Ward-Kavanagh, J Zhu, TK Cooper, TD Schell |
Cancer immunology research | 2014 |
|
Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation
M Keller, C Bollard |
ImmunoTargets and Therapy | 2014 |
|
Inhibiting glycolytic metabolism enhances CD8+ T-cell memory and anti-tumor function
Madhusudhanan Sukumar, Jie Liu, Yun Ji, Murugan Subramanian, Joseph Crompton, Zhiya Yu, Rahul Roychoudhuri, Douglas Palmer, Pawel Muranski, Edward Karoly, Robert Mohney, Christopher Klebanoff, Ashish Lal, Toren Finkel, Nicholas Restifo, Luca Gattinoni |
Journal of Clinical Investigation | 2013 |
|
In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection
S Snauwaert, G Verstichel, S Bonte, G Goetgeluk, S Vanhee, YV Caeneghem, KD Mulder, C Heirman, H Stauss, MH Heemskerk, T Taghon, G Leclercq, J Plum, AW Langerak, K Thielemans, T Kerre, B Vandekerckhove |
Leukemia Supplements | 2013 |
|
Essentials of Th17 cell commitment and plasticity
P Muranski, NP Restifo |
Blood | 2013 |
|
A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model
S Yang, GE Archer, CE Flores, DA Mitchell, JH Sampson |
Cancer Immunology, Immunotherapy | 2013 |
|
Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy
JG Crompton, M Sukumar, NP Restifo |
Immunological Reviews | 2013 |
|
Enhanced Responses to Tumor Immunization Following Total Body Irradiation Are Time-Dependent
A Diab, RR Jenq, GA Rizzuto, AD Cohen, DW Huggins, T Merghoub, ME Engelhorn, JA Guevara-Patiño, D Suh, VM Hubbard-Lucey, AA Kochman, S Chen, H Zhong, JD Wolchok, MR van Brink, AN Houghton, MA Perales, H Shiku |
PloS one | 2013 |
|
Impact of T cell selection methods in the success of clinical adoptive immunotherapy
N Ramírez, L Beloki, M Ciaúrriz, M Rodríguez-Calvillo, D Escors, C Mansilla, E Bandrés, E Olavarría |
Cellular and Molecular Life Sciences | 2013 |
|
Role of PI3K/Akt signaling in memory CD8 T cell differentiation
EH Kim, M Suresh |
Frontiers in immunology | 2013 |
|
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
JN Kochenderfer, SA Rosenberg |
Nature Reviews Clinical Oncology | 2013 |
|
Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients
A Casati, A Varghaei-Nahvi, SA Feldman, M Assenmacher, SA Rosenberg, ME Dudley, A Scheffold |
Cancer Immunology, Immunotherapy | 2013 |
|
Skin-resident antigen-presenting cells: instruction manual for vaccine development
CM Fehres, JJ Garcia-Vallejo, WW Unger, Y Kooyk |
Frontiers in immunology | 2013 |
|
Lineage relationship of effector and memory T cells
NP Restifo, L Gattinoni |
Current Opinion in Immunology | 2013 |
|
Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood
S Saito, Y Harada, Y Morodomi, M Onimaru, K Yoshida, R Kyuragi, H Matsubara, Y Yonemitsu |
Human Gene Therapy Methods | 2013 |
|
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus
S Koh, N Shimasaki, R Suwanarusk, ZZ Ho, A Chia, N Banu, SW Howland, AS Ong, AJ Gehring, H Stauss, L Renia, M Sällberg, D Campana, A Bertoletti |
Molecular Therapy — Nucleic Acids | 2013 |
|
Hematopoietic stem cells for cancer immunotherapy
E Gschweng, SD Oliveira, DB Kohn |
Immunological Reviews | 2013 |
|
Human cell-based artificial antigen-presenting cells for cancer immunotherapy
MO Butler, N Hirano |
Immunological Reviews | 2013 |
|
Chimeric antigen receptors (CARs) from bench-to-bedside
B Savoldo, G Dotti |
Immunology Letters | 2013 |
|
Histone methyltransferase and histone methylation in inflammatory T-cell responses
S He, Q Tong, DK Bishop, Y Zhang |
Immunotherapy | 2013 |
|
Rapamycin-resistant effector T-cell therapy
DH Fowler |
Immunological Reviews | 2013 |
|
The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level
VR Buchholz, P Gräf, DH Busch |
Frontiers in immunology | 2013 |
|
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
DH Fowler, ME Mossoba, SM Steinberg, DC Halverson, D Stroncek, HM Khuu, FT Hakim, L Castiello, M Sabatino, SF Leitman, J Mariotti, JC Gea-Banacloche, C Sportes, NM Hardy, DD Hickstein, SZ Pavletic, S Rowley, A Goy, M Donato, R Korngold, A Pecora, BL Levine, CH June, RE Gress, MR Bishop |
Blood | 2013 |
|
Differential Gene Expression Profile of First- and Second-Generation T-Rapa Cell Clinical Products
L Castiello, M Mossoba, A Viterbo, M Sabatino, V Fellowes, JE Foley, M Winterton, DC Halverson, S Civini, P Jin, DH Fowler, DF Stroncek |
Cytotherapy | 2013 |
|
Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition
SK Perna, D Pagliara, A Mahendravada, H Liu, MK Brenner, B Savoldo, G Dotti |
Clinical cancer research | 2013 |
|
Understanding the biology of ex vivo-expanded CD8 T cells for adoptive cell therapy: role of CD62L.
Díaz-Montero CM, Zidan AA, Pallin MF, Anagnostopoulos V, Salem ML, Wieder E, Komanduri K, Montero AJ, Lichtenheld MG |
Immunologic research | 2013 |
|
Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial
Domschke C, Ge Y, Bernhardt I, Schott S, Keim S, Juenger S, Bucur M, Mayer L, Blumenstein M, Rom J, Heil J, Sohn C, Schneeweiss A, Beckhove P, Schuetz F |
Cancer Immunology, Immunotherapy | 2013 |
|
Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype
Göthert JR, Eisele L, Klein-Hitpass L, Weber S, Zesewitz ML, Sellmann L, Röth A, Pircher H, Dührsen U, Dürig J |
Cancer Immunology, Immunotherapy | 2013 |
|
The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans
A Wang, S Chandran, SA Shah, Y Chiu, BC Paria, T Aghamolla, MM Alvarez-Downing, CC Lee, S Singh, T Li, ME Dudley, NP Restifo, SA Rosenberg, US Kammula |
Science Translational Medicine | 2012 |
|
Paths to stemness: building the ultimate antitumour T cell
L Gattinoni, CA Klebanoff, NP Restifo |
Nature Reviews Cancer | 2012 |
|
The Past, Present, and Future of Adoptive T Cell Therapy
D Choi, TG Kim, YC Sung |
Immune Network | 2012 |
|
Improving TCR Gene Therapy for Treatment of Haematological Malignancies
E Nicholson, S Ghorashian, H Stauss |
Advances in Hematology | 2012 |
|
Stimulation of Wnt/ß-Catenin Pathway in Human CD8+ T Lymphocytes from Blood and Lung Tumors Leads to a Shared Young/Memory Phenotype
MA Forget, Y Huon, A Reuben, C Grange, M Liberman, J Martin, AM Mes-Masson, N Arbour, R Lapointe |
PloS one | 2012 |
|
Immunological Heterogeneity of the RCC Microenvironment: Do Targeted Therapies Influence Immune Response?
A Bex, T Etto, F Vyth-Dreese, C Blank, AW Griffioen |
Current Oncology Reports | 2012 |
|
CD4+T Cells: Differentiation and Functions
RV Luckheeram, R Zhou, AD Verma, B Xia |
Clinical and Developmental Immunology | 2012 |
|
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
BG Till, MC Jensen, J Wang, X Qian, AK Gopal, DG Maloney, CG Lindgren, Y Lin, JM Pagel, LE Budde, A Raubitschek, SJ Forman, PD Greenberg, SR Riddell, OW Press |
Blood | 2012 |
|
How (specific) would you like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer
I Daniel-Meshulam, S Ya'akobi, C Ankri, CJ Cohen |
Frontiers in immunology | 2012 |
|
Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help
MO Butler, O Imataki, Y Yamashita, M Tanaka, S Ansén, A Berezovskaya, G Metzler, MI Milstein, MM Mooney, AP Murray, H Mano, LM Nadler, N Hirano |
PloS one | 2012 |
|
Adoptive Transfer of Mammaglobin-A Epitope Specific CD8 T Cells Combined with a Single Low Dose of Total Body Irradiation Eradicates Breast Tumors
NM Lerret, M Rogozinska, A Jaramillo, AL Marzo |
PloS one | 2012 |
|
Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models
E Rettinger, V Meyer, H Kreyenberg, A Volk, S Kuçi, A Willasch, E Koscielniak, S Fulda, WS Wels, H Boenig, T Klingebiel, P Bader |
Frontiers in Oncology | 2012 |
|
Adoptive Immunotherapy of Advanced Melanoma
R Shapira-Frommer, J Schachter |
Current Treatment Options in Oncology | 2012 |
|
Current translational and clinical practices in hematopoietic cell and gene therapy
DL Digiusto, HP Kiem |
Cytotherapy | 2012 |
|
Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor
RP Somerville, L Devillier, MR Parkhurst, SA Rosenberg, ME Dudley |
Journal of Translational Medicine | 2012 |
|
Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells
JJ Engelhardt, B Boldajipour, P Beemiller, P Pandurangi, C Sorensen, Z Werb, M Egeblad, MF Krummel |
Cancer Cell | 2012 |
|
Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails
S Yang, Y Ji, L Gattinoni, L Zhang, Z Yu, NP Restifo, SA Rosenberg, RA Morgan |
Cancer Immunology, Immunotherapy | 2012 |
|
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells
E Lugli, L Gattinoni, A Roberto, D Mavilio, DA Price, NP Restifo, M Roederer |
Nature Protocol | 2012 |
|
A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin
S Fiorenza, TJ Kenna, I Comerford, S McColl, RJ Steptoe, GR Leggatt, IH Frazer |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale
X Wang, A Naranjo, CE Brown, C Bautista, CW Wong, WC Chang, B Aguilar, JR Ostberg, SR Riddell, SJ Forman, MC Jensen |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2012 |
|
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
CA Klebanoff, L Gattinoni, NP Restifo |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2012 |
|
Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice
A Montinaro, G Forte, R Sorrentino, A Luciano, G Palma, C Arra, IM Adcock, A Pinto, S Morello |
PloS one | 2012 |
|
Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host
MP Rubinstein, CA Cloud, TE Garrett, CJ Moore, KM Schwartz, CB Johnson, DH Craig, ML Salem, CM Paulos, DJ Cole |
Journal of the American College of Surgeons | 2012 |
|
The Future Is Now: Chimeric Antigen Receptors as New Targeted Therapies for Childhood Cancer
DW Lee, DM Barrett, C Mackall, R Orentas, SA Grupp |
Clinical cancer research | 2012 |
|
Adoptive immunotherapy for cancer: harnessing the T cell response
NP Restifo, ME Dudley, SA Rosenberg |
Nature Reviews Immunology | 2012 |
|
The Immune Signature of CD8 + CCR7 + T Cells in the Peripheral Circulation Associates with Disease Recurrence in Patients with HNSCC
M Czystowska, W Gooding, MJ Szczepanski, A Lopez-Abaitero, RL Ferris, JT Johnson, TL Whiteside |
Clinical cancer research | 2012 |
|
Durable Adoptive Immunotherapy for Leukemia Produced by Manipulation of Multiple Regulatory Pathways of CD8 + T-Cell Tolerance
MM Berrien-Elliott, SR Jackson, JM Meyer, CJ Rouskey, TL Nguyen, H Yagita, PD Greenberg, RJ DiPaolo, RM Teague |
Cancer research | 2012 |
|
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
S He, J Wang, K Kato, F Xie, S Varambally, S Mineishi, R Kuick, K Mochizuki, Y Liu, E Nieves, RS Mani, AM Chinnaiyan, VE Marquez, Y Zhang |
Blood | 2011 |
|
Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells
S He, K Kato, J Jiang, DR Wahl, S Mineishi, EM Fisher, DM Murasko, GD Glick, Y Zhang, M Matloubian |
PloS one | 2011 |
|
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy
S Merims, X Li, B Joe, P Dokouhaki, M Han, RW Childs, ZY Wang, V Gupta, MD Minden, L Zhang |
Leukemia | 2011 |
|
Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy
E Proietti, F Moschella, I Capone, F Belardelli |
Molecular Oncology | 2011 |
|
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
CS Hinrichs, ZA Borman, L Gattinoni, Z Yu, WR Burns, J Huang, CA Klebanoff, LA Johnson, SP Kerkar, S Yang, P Muranski, DC Palmer, CD Scott, RA Morgan, PF Robbins, SA Rosenberg, NP Restifo |
Blood | 2011 |
|
Ex vivo gene transfer and correction for cell-based therapies
L Naldini |
Nature Reviews Genetics | 2011 |
|
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
SA Quezada, KS Peggs, TR Simpson, JP Allison |
Immunological Reviews | 2011 |
|
Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
CA Klebanoff, L Gattinoni, DC Palmer, P Muranski, Y Ji, CS Hinrichs, ZA Borman, SP Kerkar, CD Scott, SE Finkelstein, SA Rosenberg, NP Restifo |
Clinical cancer research | 2011 |
|
In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells
S Yang, L Gattinoni, G Luca, F Liu, Y Ji, Z Yu, NP Restifo, SA Rosenberg, RA Morgan |
Cancer Immunology, Immunotherapy | 2011 |
|
The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes
S Yang, F Liu, QJ Wang, SA Rosenberg, RA Morgan |
PloS one | 2011 |
|
Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy
T Zuliani, J David, S Bercegeay, MC Pandolfino, I Rodde-Astier, A Khammari, C Coissac, B Delorme, S Saïagh, B Dréno |
Journal of Translational Medicine | 2011 |
|
Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses
WL Denning, J Xu, S Guo, CA Klug, Z Hel |
PloS one | 2011 |
|
Immunotherapy for EBV-associated malignancies
A Merlo, R Turrini, R Dolcetti, P Zanovello, A Rosato |
International Journal of Hematology | 2011 |
|
Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature
P Muranski, ZA Borman, SP Kerkar, CA Klebanoff, Y Ji, L Sanchez-Perez, M Sukumar, RN Reger, Z Yu, SJ Kern, R Roychoudhuri, GA Ferreyra, W Shen, SK Durum, L Feigenbaum, DC Palmer, PA Antony, CC Chan, A Laurence, RL Danner, L Gattinoni, NP Restifo |
Immunity | 2011 |
|
A human memory T-cell subset with stem cell-like properties
L Gattinoni, E Lugli, Y Ji, Z Pos, CM Paulos, MF Quigley, JR Almeida, E Gostick, Z Yu, C Carpenito, E Wang, DC Douek, DA Price, CH June, FM Marincola, M Roederer, NP Restifo |
Nature Medicine | 2011 |
|
Genetic engineering of murine CD8+ and CD4+ T cells for pre-clinical adoptive immunotherapy studies
SP Kerkar, L Sanchez-Perez, S Yang, ZA Borman, P Muranski, Y Ji, D Chinnasamy, AD Kaiser, CS Hinrichs, CA Klebanoff, CD Scott, L Gattinoni, RA Morgan, SA Rosenberg, NP Restifo |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2011 |
|
Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28
JS Pufnock, M Cigal, LS Rolczynski, E Andersen-Nissen, M Wolfl, MJ McElrath, PD Greenberg |
Blood | 2011 |
|
Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model
DN Lisiero, H Soto, LM Liau, RM Prins |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer
RP Dings, KB Vang, K Castermans, F Popescu, Y Zhang, MG Egbrink, MF Mescher, MA Farrar, AW Griffioen, KH Mayo |
Clinical cancer research | 2011 |
|
Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes
S Muralidharan, PJ Hanley, E Liu, R Chakraborty, C Bollard, E Shpall, C Rooney, B Savoldo, J Rodgers, G Dotti |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Augmented lymphocyte expansion from solid tumors with engineered cells for costimulatory enhancement
KM Friedman, LE Devillier, SA Feldman, SA Rosenberg, ME Dudley |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2011 |
|
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
Q Ye, M Loisiou, BL Levine, MM Suhoski, JL Riley, CH June, G Coukos, DJ Powell |
Journal of Translational Medicine | 2011 |
|
Hepatitis C Virus NS3/NS4A DNA Vaccine Induces Multiepitope T Cell Responses in Rhesus Macaques Mimicking Human Immune Responses
KA Kuhs, AA Ginsberg, J Yan, RW Wiseman, AS Khan, NY Sardesai, DH O'Connor, DB Weiner |
Molecular Therapy | 2011 |
|
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
SA Rosenberg, JC Yang, RM Sherry, US Kammula, MS Hughes, GQ Phan, DE Citrin, NP Restifo, PF Robbins, JR Wunderlich, KE Morton, CM Laurencot, SM Steinberg, DE White, ME Dudley |
Clinical cancer research | 2011 |
|
Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity
Y Nesbeth, JR Conejo-Garcia |
Clinical and Developmental Immunology | 2010 |
|
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
JC Markley, M Sadelain |
Blood | 2010 |
|
Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice
GH Lin, Y Liu, T Ambagala, BS Kwon, PS Ohashi, TH Watts |
PloS one | 2010 |
|
Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma
Y Xie, A Akpinarli, C Maris, EL Hipkiss, M Lane, EK Kwon, P Muranski, NP Restifo, PA Antony |
Journal of Experimental Medicine | 2010 |
|
Focus on adoptive T cell transfer trials in melanoma
L Hershkovitz, J Schachter, AJ Treves, MJ Besser |
Clinical & developmental immunology | 2010 |
|
Therapeutic cancer vaccines: are we there yet?
CA Klebanoff, N Acquavella, Z Yu, NP Restifo |
Immunological Reviews | 2010 |
|
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
C Wrzesinski, CM Paulos, A Kaiser, P Muranski, DC Palmer, L Gattinoni, Z Yu, SA Rosenberg, NP Restifo |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2010 |
|
A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells
C Aspord, J Charles, MT Leccia, D Laurin, MJ Richard, L Chaperot, J Plumas |
PloS one | 2010 |
|
Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer
M Cartellieri, M Bachmann, A Feldmann, C Bippes, S Stamova, R Wehner, A Temme, M Schmitz |
Journal of Biomedicine and Biotechnology | 2010 |
|
Features of responding T cells in cancer and chronic infection
PS Kim, R Ahmed |
Current Opinion in Immunology | 2010 |
|
Phenotype, functions and fate of adoptively transferred tumor draining lymphocytes activated ex vivo in mice with an aggressive weakly immunogenic mammary carcinoma
CH Miller, L Graham, HD Bear |
BMC Immunology | 2010 |
|
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines
E Tran, JS Nielsen, DA Wick, AV Ng, LD Johnson, NJ Nesslinger, E McMurtrie, JR Webb, BH Nelson |
PloS one | 2010 |
|
Impact of γ-chain cytokines on EBV-specific T cell cultures
A Merlo, R Turrini, C Trento, P Zanovello, R Dolcetti, A Rosato |
Journal of Translational Medicine | 2010 |
|
Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation
Y Li, RJ Kurlander |
Journal of Translational Medicine | 2010 |
|
Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine
ME Kohler, WH Hallett, QR Chen, J Khan, BD Johnson, RJ Orentas |
Cellular Immunology | 2010 |
|
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
RK Shrimali, Z Yu, MR Theoret, D Chinnasamy, NP Restifo, SA Rosenberg |
Cancer research | 2010 |
|
A critical role for virus-specific CD8(+) CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice
MT Getts, MH Richards, SD Miller |
Virology | 2010 |
|
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
SA Quezada, TR Simpson, KS Peggs, T Merghoub, J Vider, X Fan, R Blasberg, H Yagita, P Muranski, PA Antony, NP Restifo, JP Allison |
Journal of Experimental Medicine | 2010 |
|
Immunotherapy through T-cell receptor gene transfer induces severe graft-versus-host disease
J Ferrara, P Reddy, S Paczesny |
Immunotherapy | 2010 |
|
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
GM Bendle, C Linnemann, AI Hooijkaas, L Bies, MA de Witte, A Jorritsma, AD Kaiser, N Pouw, R Debets, E Kieback, W Uckert, JY Song, JB Haanen, TN Schumacher |
Nature Medicine | 2010 |
|
IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy
MW Helms, JA Prescher, YA Cao, S Schaffert, CH Contag |
Cancer Immunology, Immunotherapy | 2010 |
|
The impact of ex vivo clinical grade activation protocols on human T cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy
PC Tumeh, RC Koya, T Chodon, NA Graham, TG Graeber, B Comin-Anduix, A Ribas |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2010 |
|
Predicting Cytotoxic T-cell Age from Multivariate Analysis of Static and Dynamic Biomarkers*
CA Rivet, AS Hill, H Lu, ML Kemp |
Molecular & cellular proteomics : MCP | 2010 |
|
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion
SL Goff, LA Johnson, MA Black, H Xu, Z Zheng, CJ Cohen, RA Morgan, SA Rosenberg, SA Feldman |
Cancer Immunology, Immunotherapy | 2010 |
|
Prevention of Interleukin-2 Withdrawal-Induced Apoptosis in Lymphocytes Retrovirally Cotransduced With Genes Encoding an Antitumor T-cell Receptor and an Antiapoptotic Protein:
A Kalbasi, RK Shrimali, D Chinnasamy, SA Rosenberg |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2010 |
|
Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy
L Gattinoni, Y Ji, NP Restifo |
Clinical cancer research | 2010 |
|
Self-Specific CD8 + T Cells Maintain a Semi-Naive State Following Lymphopenia-Induced Proliferation
LD Johnson, SC Jameson |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
A Simplified Method for the Clinical-scale Generation of Central Memory-like CD8+ T Cells After Transduction With Lentiviral Vectors Encoding Antitumor Antigen T-cell Receptors
S Yang, ME Dudley, SA Rosenberg, RA Morgan |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2010 |
|
Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells
Pouw N, Treffers-Westerlaken E, Kraan J, Wittink F, ten Hagen T, Verweij J, Debets R |
Cancer Immunology, Immunotherapy | 2010 |
|
IL-21-treated naive CD45RA+ CD8+ T cells represent a reliable source for producing leukemia-reactive cytotoxic T lymphocytes with high proliferative potential and early differentiation phenotype
Albrecht J, Frey M, Teschner D, Carbol A, Theobald M, Herr W, Distler E |
Cancer Immunology, Immunotherapy | 2010 |
|
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response
GA Rizzuto, T Merghoub, D Hirschhorn-Cymerman, C Liu, AM Lesokhin, D Sahawneh, H Zhong, KS Panageas, MA Perales, G Altan-Bonnet, JD Wolchok, AN Houghton |
Journal of Experimental Medicine | 2009 |
|
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion
Y Nesbeth, U Scarlett, J Cubillos-Ruiz, D Martinez, X Engle, MJ Turk, JR Conejo-Garcia |
Cancer research | 2009 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Use of tumour-responsive T cells as cancer treatment
ML Disis, H Bernhard, EM Jaffee |
Lancet | 2009 |
|
Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase
EB Santos, R Yeh, J Lee, Y Nikhamin, B Punzalan, B Punzalan, KL Perle, SM Larson, M Sadelain, RJ Brentjens |
Nature Medicine | 2009 |
|
Treatment of lymphoma with adoptively transferred T cells
BG Till, OW Press |
Expert Opinion on Biological Therapy | 2009 |
|
Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination
CA Klebanoff, Z Yu, LN Hwang, DC Palmer, L Gattinoni, NP Restifo |
Blood | 2009 |
|
Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma
E Huarte, J Fisher, MJ Turk, D Mellinger, C Foster, B Wolf, KR Meehan, CE Fadul, MS Ernstoff |
Cancer Letters | 2009 |
|
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function
DC Palmer, NP Restifo |
Trends in Immunology | 2009 |
|
Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications
S Han, Y Huang, Y Liang, Y Ho, Y Wang, LJ Chang |
Journal of Hematology & Oncology | 2009 |
|
Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell
YC Linn, SK Lau, BH Liu, LH Ng, HX Yong, KM Hui |
Immunology | 2009 |
|
HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells
B Dai, L Yang, H Yang, B Hu, D Baltimore, P Wang |
Proceedings of the National Academy of Sciences | 2009 |
|
IL-7 + IL-15 are superior to IL-2 for the ex vivo expansion of 4T1 mammary carcinoma-specific T cells with greater efficacy against tumors in vivo
E Cha, L Graham, MH Manjili, HD Bear |
Breast Cancer Research and Treatment | 2009 |
|
Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2
HK Le, L Graham, CH Miller, M Kmieciak, MH Manjili, HD Bear |
Cancer Immunology, Immunotherapy | 2009 |
|
Functions of gammaC cytokines in immune homeostasis: current and potential clinical applications
WW Overwijk, KS Schluns |
Clinical Immunology | 2009 |
|
T Cell Receptor Gene Therapy for Cancer
TM Schmitt, GB Ragnarsson, PD Greenberg |
Human Gene Therapy | 2009 |
|
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
CS Hinrichs, ZA Borman, L Cassard, L Gattinoni, R Spolski, Z Yu, L Sanchez-Perez, P Muranski, SJ Kern, C Logun, DC Palmer, Y Ji, RN Reger, WJ Leonard, RL Danner, SA Rosenberg, NP Restifo |
Proceedings of the National Academy of Sciences | 2009 |
|
Tc17 CD8 T cells: functional plasticity and subset diversity
HR Yen, TJ Harris, S Wada, JF Grosso, D Getnet, MV Goldberg, KL Liang, TC Bruno, KJ Pyle, SL Chan, RA Anders, CL Trimble, AJ Adler, TY Lin, DM Pardoll, CT Huang, CG Drake |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses
YP Lai, CC Lin, WJ Liao, CY Tang, SC Chen |
PloS one | 2009 |
|
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
GP Wright, CA Notley, SA Xue, GM Bendle, A Holler, TN Schumacher, MR Ehrenstein, HJ Stauss |
Proceedings of the National Academy of Sciences | 2009 |
|
Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
SE James, NN Orgun, TF Tedder, MJ Shlomchik, MC Jensen, Y Lin, PD Greenberg, OW Press |
Blood | 2009 |
|
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
XS Zhong, M Matsushita, J Plotkin, I Riviere, M Sadelain |
Molecular Therapy | 2009 |
|
Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells
KA Shafer-Weaver, SK Watkins, MJ Anderson, LJ Draper, A Malyguine, WG Alvord, NM Greenberg, AA Hurwitz |
Cancer research | 2009 |
|
Genetic modification of T cells with IL-21 enhances antigen presentation and generation of central memory tumor-specific cytotoxic T-lymphocytes
AS Kaka, DR Shaffer, R Hartmaier, R Hartmeier, AM Leen, A Lu, A Bear, CM Rooney, AE Foster |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2009 |
|
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
L Gattinoni, XS Zhong, DC Palmer, Y Ji, CS Hinrichs, Z Yu, C Wrzesinski, A Boni, L Cassard, LM Garvin, CM Paulos, P Muranski, NP Restifo |
Nature Medicine | 2009 |
|
Type 17 CD8+ T cells display enhanced antitumor immunity
CS Hinrichs, A Kaiser, CM Paulos, L Cassard, L Sanchez-Perez, B Heemskerk, C Wrzesinski, ZA Borman, P Muranski, NP Restifo |
Blood | 2009 |
|
Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy
JA Klapper, AA Thomasian, DM Smith, GC Gorgas, JR Wunderlich, FO Smith, BS Hampson, SA Rosenberg, ME Dudley |
Journal of Immunological Methods | 2009 |
|
Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras
A Ghosh, W Koestner, M Hapke, V Schlaphoff, F Länger, R Baumann, C Koenecke, M Cornberg, K Welte, BR Blazar, MG Sauer |
Blood | 2009 |
|
Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes
PM Rabinovich, ME Komarovskaya, SH Wrzesinski, JL Alderman, T Budak-Alpdogan, A Karpikov, H Guo, RA Flavell, NK Cheung, SM Weissman, E Bahceci |
Human Gene Therapy | 2009 |
|
Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry
L Gattinoni, CA Klebanoff, NP Restifo |
Science Translational Medicine | 2009 |
|
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity
PD Peng, CJ Cohen, S Yang, C Hsu, S Jones, Y Zhao, Z Zheng, SA Rosenberg, RA Morgan |
Gene Therapy | 2009 |
|
Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes
C Deb, CL Howe |
Journal of Neuroimmunology | 2009 |
|
Adoptive cell therapy for the treatment of patients with metastatic melanoma
SA Rosenberg, ME Dudley |
Current Opinion in Immunology | 2009 |
|
Cooperation between Molecular Targets of Costimulation in Promoting T Cell Persistence and Tumor Regression
B Zhao, A Song, R Haque, F Lei, L Weiler, X Xiong, Y Wu, M Croft, J Song |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
Immunomodulation in the treatment of haematological malignancies.
Cesco-Gaspere M, Morris E, Stauss HJ |
Clinical and Experimental Medicine | 2009 |
|
Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection
Chen IH, Lai YL, Wu CL, Chang YF, Chu CC, Tsai IF, Sun FJ, Lu YT |
Cancer Immunology, Immunotherapy | 2009 |
|
Organ-derived dendritic cells have differential effects on alloreactive T cells
TD Kim, TH Terwey, JL Zakrzewski, D Suh, AA Kochman, ME Chen, CG King, C Borsotti, J Grubin, OM Smith, G Heller, C Liu, GF Murphy, O Alpdogan, MR van Brink |
Blood | 2008 |
|
TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation
MA de Witte, GM Bendle, MD van Boom, M Coccoris, TD Schell, SS Tevethia, H Tinteren, EM Mesman, JY Song, TN Schumacher |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2
B Heemskerk, K Liu, ME Dudley, LA Johnson, A Kaiser, S Downey, Z Zheng, TE Shelton, K Matsuda, PF Robbins, RA Morgan, SA Rosenberg |
Human Gene Therapy | 2008 |
|
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
S Matsumura, B Wang, N Kawashima, S Braunstein, M Badura, TO Cameron, JS Babb, RJ Schneider, SC Formenti, ML Dustin, S Demaria |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen
CJ Shu, CG Radu, SM Shelly, DD Vo, R Prins, A Ribas, ME Phelps, ON Witte |
International Immunology | 2008 |
|
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain
RM Prins, CJ Shu, CG Radu, DD Vo, H Khan-Farooqi, H Soto, MY Yang, MS Lin, S Shelly, ON Witte, A Ribas, LM Liau |
Cancer Immunology, Immunotherapy | 2008 |
|
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
CS Hinrichs, R Spolski, CM Paulos, L Gattinoni, KW Kerstann, DC Palmer, CA Klebanoff, SA Rosenberg, WJ Leonard, NP Restifo |
Blood | 2008 |
|
Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity
N Asprodites, L Zheng, D Geng, C Velasco-Gonzalez, L Sanchez-Perez, E Davila |
The FASEB Journal | 2008 |
|
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
SA Rosenberg, NP Restifo, JC Yang, RA Morgan, ME Dudley |
Nature reviews. Cancer | 2008 |
|
Immunotherapy for Advanced Melanoma
L Fang, AS Lonsdorf, ST Hwang |
Journal of Investigative Dermatology | 2008 |
|
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers
A Boni, P Muranski, L Cassard, C Wrzesinski, CM Paulos, DC Palmer, L Gattinoni, CS Hinrichs, CC Chan, SA Rosenberg, NP Restifo |
Blood | 2008 |
|
Use of high throughput qPCR screening to rapidly clone low frequency tumour specific T-cells from peripheral blood for adoptive immunotherapy
US Kammula, OK Serrano |
Journal of Translational Medicine | 2008 |
|
Genetic engineering of T cells for adoptive immunotherapy
A Varela-Rohena, C Carpenito, EE Perez, M Richardson, RV Parry, M Milone, J Scholler, X Hao, A Mexas, RG Carroll, CH June, JL Riley |
Immunologic Research | 2008 |
|
Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy
KQ Tran, J Zhou, KH Durflinger, MM Langhan, TE Shelton, JR Wunderlich, PF Robbins, SA Rosenberg, ME Dudley |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2008 |
|
Chimeric NKG2D receptor-expressing T cells as an immunotherapy for multiple myeloma
A Barber, T Zhang, CJ Megli, J Wu, KR Meehan, CL Sentman |
Experimental Hematology | 2008 |
|
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
S Yang, CJ Cohen, PD Peng, Y Zhao, L Cassard, Z Yu, Z Zheng, S Jones, NP Restifo, SA Rosenberg, RA Morgan |
Gene Therapy | 2008 |
|
T-cell receptor gene therapy of established tumors in a murine melanoma model
JD Abad, C Wrzensinski, W Overwijk, MA de Witte, A Jorritsma, C Hsu, L Gattinoni, CJ Cohen, CM Paulos, DC Palmer, JB Haanen, TN Schumacher, SA Rosenberg, NP Restifo, RA Morgan |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2008 |
|
CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy
K Watanabe, S Suzuki, M Kamei, S Toji, T Kawase, T Takahashi, K Kuzushima, Y Akatsuka |
International Journal of Hematology | 2008 |
|
Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less differentiated cells
S Yang, SA Rosenberg, RA Morgan |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2008 |
|
Adoptive immunotherapy: good habits instilled at youth have long-term benefits
CM Paulos, MM Suhoski, G Plesa, T Jiang, S Basu, TN Golovina, S Jiang, NA Aqui, DJ Powell, BL Levine, RG Carroll, JL Riley, CH June |
Immunologic Research | 2008 |
|
Transforming Growth Factor-β Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers
A Wallace, V Kapoor, J Sun, P Mrass, W Weninger, DF Heitjan, C June, LR Kaiser, LE Ling, SM Albelda |
Clinical cancer research | 2008 |
|
CD8+ T Cells Targeting A Single Immunodominant Epitope Are Sufficient for Elimination of Established SV40 T Antigen-Induced Brain Tumors
Tatum AM, Mylin LM, Bender SJ, Fischer MA, Vigliotti BA, Tevethia MJ, Tevethia SS, Schell TD |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing
Watchmaker PB, Urban JA, Berk E, Nakamura Y, Mailliard RB, Watkins SC, van Ham SM, Kalinski P |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Treatment of advanced metastasized breast cancer with bone marrow-derived tumour-reactive memory T cells: a pilot clinical study
Schuetz F, Ehlert K, Ge Y, Schneeweiss A, Rom J, Inzkirweli N, Sohn C, Schirrmacher V, Beckhove P |
Cancer Immunology, Immunotherapy | 2008 |
|
Hematopoietic stem cells promote the expansion and function of adoptively transferred anti-tumor CD8+ T cells
Claudia Wrzesinski, Chrystal M Paulos, Luca Gattinoni, Douglas C. Palmer, Andrew Kaiser , Zhiya Yu, Steven A. Rosenberg and Nicholas P. Restifo |
Journal of Clinical Investigation | 2007 |
|
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via toll-like receptor 4 signaling
Chrystal M. Paulos, Claudia Wrzesinski, Andrew Kaiser, Christian S. Hinrichs, Marcello Chieppa, Lydie Cassard, Douglas C. Palmer, Andrea Boni, Pawel Muranski, Zhiya Yu, Luca Gattinoni, Paul A. Antony, Steven A. Rosenberg, and Nicholas P. Restifo |
Journal of Clinical Investigation | 2007 |
|
Toll-like receptors in tumor immunotherapy
CM Paulos, A Kaiser, C Wrzesinski, CS Hinrichs, L Cassard, A Boni, P Muranski, L Sanchez-Perez, DC Palmer, Z Yu, PA Antony, L Gattinoni, SA Rosenberg, NP Restifo |
Clinical cancer research | 2007 |
|
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
MJ Pittet, J Grimm, CR Berger, T Tamura, G Wojtkiewicz, M Nahrendorf, P Romero, FK Swirski, R Weissleder |
Proceedings of the National Academy of Sciences | 2007 |
|
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
KV Komanduri, LS st John, M Lima, J McMannis, S Rosinski, I McNiece, SG Bryan, I Kaur, S Martin, ED Wieder, L Worth, LJ Cooper, D Petropoulos, JJ Molldrem, RE Champlin, EJ Shpall |
Blood | 2007 |
|
Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors
JL Yorty, SS Tevethia, TD Schell |
Cancer Immunology, Immunotherapy | 2007 |
|
Rapid maturation of effector T cells in tumors, but not lymphoid organs, during tumor regression
LA Norian, PM Allen |
PloS one | 2007 |
|
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
K Rezvani, AS Yong, BN Savani, S Mielke, K Keyvanfar, E Gostick, DA Price, DC Douek, AJ Barrett |
Blood | 2007 |
|
Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities
M Wolfl, J Kuball, WY Ho, H Nguyen, TJ Manley, M Bleakley, PD Greenberg |
Blood | 2007 |
|
Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling
Y Zhao, MR Parkhurst, Z Zheng, CJ Cohen, JP Riley, L Gattinoni, NP Restifo, SA Rosenberg, RA Morgan |
Cancer research | 2007 |
|
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model
CM Díaz-Montero, SE Naggar, AA Khami, RE Naggar, AJ Montero, DJ Cole, ML Salem |
Cancer Immunology, Immunotherapy | 2007 |
|
Primary immune surveillance: some like it hot
JJ Skitzki, Q Chen, WC Wang, SS Evans |
Journal of Molecular Medicine | 2007 |
|
Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer
Bernhard H, Neudorfer J, Gebhard K, Conrad H, Hermann C, Nährig J, Fend F, Weber W, Busch DH, Peschel C |
Cancer Immunology, Immunotherapy | 2007 |
|
CD8+ T-cell memory in tumor immunology and immunotherapy
CA Klebanoff, L Gattinoni, NP Restifo |
Immunological Reviews | 2006 |
|
Programming CD8+ T cells for effective immunotherapy
CS Hinrichs, L Gattinoni, NP Restifo |
Current Opinion in Immunology | 2006 |
|
Combined IL-21 and Low-Dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model
H He, P Wisner, G Yang, HM Hu, D Haley, W Miller, A O'Hara, WG Alvord, CH Clegg, BA Fox, WJ Urba, EB Walker |
Journal of Translational Medicine | 2006 |
|
Adoptive immunotherapy for cancer: building on success
L Gattinoni, DJ Powell, SA Rosenberg, NP Restifo |
Nature Reviews Immunology | 2006 |
|
Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?
P Muranski, A Boni, C Wrzesinski, DE Citrin, SA Rosenberg, R Childs, NP Restifo |
Nature clinical practice. Oncology | 2006 |
|
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
MH Kershaw, JA Westwood, LL Parker, G Wang, Z Eshhar, SA Mavroukakis, DE White, JR Wunderlich, S Canevari, L Rogers-Freezer, CC Chen, JC Yang, SA Rosenberg, P Hwu |
Clinical cancer research | 2006 |
|
CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation
JM Carr, MJ Carrasco, JE Thaventhiran, PJ Bambrough, M Kraman, AD Edwards, A Al-Shamkhani, DT Fearon |
Proceedings of the National Academy of Sciences | 2006 |
|
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent
L Gattinoni, A Ranganathan, DR Surman, DC Palmer, PA Antony, MR Theoret, DM Heimann, SA Rosenberg, NP Restifo |
Blood | 2006 |
|
Adoptive Transfer of Vaccine-Induced Peripheral Blood Mononuclear Cells to Patients with Metastatic Melanoma following Lymphodepletion
Powell DJ Jr, Dudley ME, Hogan KA, Wunderlich JR, Rosenberg SA |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes
Johnson LA, Heemskerk B, Powell DJ Jr, Cohen CJ, Morgan RA, Dudley ME, Robbins PF, Rosenberg SA |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo
Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, Sato N, Kaiser A, Heinrichs C, Klebanoff CA, Tagaya Y, Restifo NP |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Modulation by IL-2 of CD70 and CD27 Expression on CD8+ T Cells: Importance for the Therapeutic Effectiveness of Cell Transfer Immunotherapy
Huang J, Kerstann KW, Ahmadzadeh M, Li YF, El-Gamil M, Rosenberg SA, Robbins PF |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
CA Klebanoff, L Gattinoni, P Torabi-Parizi, K Kerstann, AR Cardones, SE Finkelstein, DC Palmer, PA Antony, ST Hwang, SA Rosenberg, TA Waldmann, NP Restifo |
Proceedings of the National Academy of Sciences | 2005 |
|
Toward improved immunocompetence of adoptively transferred CD8+ T cells
DE Speiser, P Romero |
Journal of Clinical Investigation | 2005 |
|
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells
L Gattinoni, SE Finkelstein, CA Klebanoff, PA Antony, DC Palmer, PJ Spiess, LN Hwang, Z Yu, C Wrzesinski, DM Heimann, CD Surh, SA Rosenberg, NP Restifo |
Journal of Experimental Medicine | 2005 |
|
High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation
Y Zhao, Z Zheng, CJ Cohen, L Gattinoni, DC Palmer, NP Restifo, SA Rosenberg, RA Morgan |
Molecular therapy : the journal of the American Society of Gene Therapy | 2005 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)