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Usage Information

Genetic causes of human heart failure
Hiroyuki Morita, … , Jonathan Seidman, Christine E. Seidman
Hiroyuki Morita, … , Jonathan Seidman, Christine E. Seidman
Published March 1, 2005
Citation Information: J Clin Invest. 2005;115(3):518-526. https://doi.org/10.1172/JCI24351.
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Review Series Article has an altmetric score of 7

Genetic causes of human heart failure

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Abstract

Factors that render patients with cardiovascular disease at high risk for heart failure remain incompletely defined. Recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure. Through analyses of the mechanisms by which a mutation selectively perturbs one component of cardiac physiology and triggers cell and molecular responses, studies of human gene mutations provide a window into the complex processes of cardiac remodeling and heart failure. Knowledge gleaned from these studies shows promise for defining novel therapeutic targets for genetic and acquired causes of heart failure.

Authors

Hiroyuki Morita, Jonathan Seidman, Christine E. Seidman

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,365 0
PDF 131 0
Figure 462 0
Citation downloads 62 0
Totals 2,020 0
Total Views 2,020
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