Citations to this article

Host-based antipoxvirus therapeutic strategies: turning the tables
Anthony S. Fauci, Mark D. Challberg
Anthony S. Fauci, Mark D. Challberg
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):231-233. https://doi.org/10.1172/JCI24270.
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Commentary

Host-based antipoxvirus therapeutic strategies: turning the tables

Abstract

The potential threat of the smallpox virus as a bioterror weapon has long been recognized, and the need for developing suitable countermeasures has become especially acute following the events of September 2001. Traditional antiviral agents interfere with viral proteins or functions. In a new study, Yang et al. focus instead on host cellular pathways used by the virus. A drug that interferes with the cellular ErbB-1 signal transduction pathway, activated by smallpox growth factor, sheds new light on how the virus replicates in the cell. Drugs that target the ErbB-signaling pathways represent a promising new class of antiviral agents.

Authors

Anthony S. Fauci, Mark D. Challberg

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Citations to this article (10)

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Synthesis and antiviral activities of new acyclic and “double-headed” nucleoside analogues
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Toward Orthopoxvirus Countermeasures:  A Novel Heteromorphic Nucleoside of Unusual Structure
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