Breach of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus (SLE). However, how B cell tolerance is subverted in human SLE is poorly understood due to difficulties in identifying relevant autoreactive B cells and in obtaining lymphoid tissue. We have circumvented these limitations by using tonsil biopsies to study autoreactive B cells (9G4 B cells), whose regulation is abnormal in SLE. Here we show that 9G4 B cells are physiologically excluded during the early stages of the GC reaction before acquiring a centroblast phenotype. Furthermore, we provide evidence to indicate that an anergic response to B cell receptor stimulation may be responsible for such behavior. In contrast, in SLE, 9G4 B cells progressed unimpeded through this checkpoint, successfully participated in GC reactions, and expanded within the post-GC IgG memory and plasma cell compartments. The faulty regulation of 9G4 B cells was not shared by RA patients. To our knowledge, this work represents the first comparative analysis of the fate of a specific autoreactive human B cell population. The results identify a defective tolerance checkpoint that appears to be specific for human SLE.
Amedeo Cappione III, Jennifer H. Anolik, Aimee Pugh-Bernard, Jennifer Barnard, Paul Dutcher, Gregg Silverman, Iñaki Sanz
Title and authors | Publication | Year |
---|---|---|
Hypomorphic RAG2 Deficiency Promotes Selection of Self-Reactive B Cells
Thouvenel CD, Tipton CM, Yamazaki Y, Zhang TT, Rylaarsdam S, Hom JR, Snead C, Zhu C, Li QZ, Lee YN, Kawai T, Haque N, Zimmermann MT, Ponnan SM, Jackson SW, James RG, Sanz I, Notarangelo LD, Torgerson TR, Ochs HD, Rawlings DJ, Allenspach EJ |
Journal of Clinical Immunology | 2025 |
Organ-based characterization of B cells in patients with systemic lupus erythematosus
Wang Y, Zhao R, Liang Q, Ni S, Yang M, Qiu L, Ji J, Gu Z, Dong C |
Frontiers in Immunology | 2025 |
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Fike AJ, Bricker KN, Gonzalez MV, Maharjan A, Bui T, Nuon K, Emrich SM, Weber JL, Luckenbill SA, Choi NM, Sauteraud R, Liu DJ, Olsen NJ, Caricchio R, Trebak M, Chodisetti SB, Rahman ZS |
bioRxiv | 2025 |
Human naïve B cells show evidence of anergy and clonal redemption following vaccination
Dizon BL, Holla P, Mutic EC, Schaughency P, Pierce SK |
NPJ Vaccines | 2025 |
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Fike AJ, Bricker KN, Gonzalez MV, Maharjan A, Bui T, Nuon K, Emrich SM, Weber JL, Luckenbill SA, Choi NM, Sauteraud R, Liu DJ, Olsen NJ, Caricchio R, Trebak M, Chodisetti SB, Rahman ZS |
The Journal of Experimental Medicine | 2025 |
B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.
Wang Q, Feng D, Jia S, Lu Q, Zhao M |
Clinical Reviews in Allergy & Immunology | 2024 |
The STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice
Alee I, Chantawichitwong P, Leelahavanichkul A, Paludan SR, Pisitkun T, Pisitkun P |
Scientific Reports | 2024 |
Invasion of spontaneous germinal centers by naive B cells is rapid and persistent
van den Broek T, Oleinika K, Rahmayanti S, Castrillon C, van der Poel CE, Carroll MC |
Science Immunology | 2024 |
Germinal Center vs Extrafollicular Responses in Systemic Autoimmunity: Who Turns the Blade on Self?
He Y, Vinuesa CG |
Advances in immunology | 2024 |
Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
Sanchez GM, Hirsch ES, VanValkenburg A, Mayer DP, Gbedande K, Francis RL, Song W, Antao OQ, Brimmer KE, Lemenze A, Stephens R, Johnson WE, Weinstein JS |
Cell reports | 2024 |
Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases
Clarke T, Du P, Kumar S, Okitsu SL, Schuette M, An Q, Zhang J, Tzvetkov E, Jensen MA, Niewold TB, Ferre EM, Nardone J, Lionakis MS, Vlach J, DeMartino J, Bender AT |
Frontiers in immunology | 2023 |
Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus.
Gomez-Bañuelos E, Yu Y, Li J, Cashman KS, Paz M, Trejo-Zambrano MI, Bugrovsky R, Wang Y, Chida AS, Sherman-Baust CA, Ferris DP, Goldman DW, Darrah E, Petri M, Sanz I, Andrade F |
Nature Communications | 2023 |
CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring
Vergani S, Bagnara D, Agathangelidis A, Ng AK, Ferrer G, Mazzarello AN, Palacios F, Yancopoulos S, Yan XJ, Barrientos JC, Rai KR, Stamatopoulos K, Chiorazzi N |
Frontiers in Oncology | 2023 |
Differential impact of environmental factors on systemic and localized autoimmunity
Touil H, Mounts K, De Jager PL |
Frontiers in immunology | 2023 |
Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies
Joyce C, Murrell S, Murrell B, Omorodion O, Ver LS, Carrico N, Bastidas R, Nedellec R, Bick M, Woehl J, Zhao F, Burns A, Barman S, Appel M, Ramos A, Wickramasinghe L, Eren K, Vollbrecht T, Smith DM, Kosakovsky Pond SL, McBride R, Worth C, Batista F, Sok D, Poignard P, Briney B, Wilson IA, Landais E, Burton DR |
PLoS pathogens | 2023 |
Invasion of spontaneous germinal centers by naive B cells is rapid and persistent
van den Broek T, Oleinika K, Rahmayanti S, Castrillon C, van der Poel CE, Carroll MC |
2023 | |
Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
Castrillon C, Simoni L, van den Broek T, van der Poel C, Akama-Garren EH, Ma M, Carroll MC |
eLife | 2023 |
CD27 on human memory B cells-more than just a surface marker.
Grimsholm O |
Clinical & Experimental Immunology | 2023 |
Clonal redemption of B cells in cancer
McCaw TR, Lofftus SY, Crompton JG |
Frontiers in immunology | 2023 |
Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation
Bauer-Smith H, Sudol AS, Beers SA, Crispin M |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2023 |
Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies
J Peterson, S Boackle, S Taitano, A Sang, J Lang, M Kelly, J Rahkola, A Miranda, R Sheridan, J Thurman, V Rao, R Torres, R Pelanda |
Frontiers in immunology | 2022 |
The Immunogenetics of Dermatologic Diseases
N Rezaei, F Rajabi |
2022 | |
The tangled web of autoreactive B cells in malaria immunity and autoimmune disease
B Dizon, S Pierce |
Trends in Parasitology | 2022 |
Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications
J Li, M Luo, B Li, Y Lou, Y Zhu, X Bai, B Sun, X Lu, P Luo |
Frontiers in immunology | 2022 |
SARS-CoV-2 infection relaxes peripheral B cell tolerance
M Castleman, M Stumpf, N Therrien, M Smith, K Lesteberg, B Palmer, J Maloney, W Janssen, K Mould, J Beckham, R Pelanda, R Torres |
Journal of Experimental Medicine | 2022 |
Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review
J Sarrand, M Soyfoo |
International journal of molecular sciences | 2022 |
Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans
Harley IT, Allison K, Scofield RH |
Frontiers in immunology | 2022 |
Impact of Corticosteroids on the Proportions of Circulating Tfh Cell Subsets in Patients With Systemic Lupus Erythematous
Mao M, Xu S, Lin L, Dong D, Xue M, He S, Cai G |
Frontiers in Medicine | 2022 |
Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients.
Hurtado C, Rojas-Gualdrón DF, Urrego R, Cashman K, Vásquez-Trespalacios EM, Díaz-Coronado JC, Rojas M, Jenks S, Vásquez G, Sanz I |
Frontiers in Medicine | 2022 |
CD4+ T-cell cooperation promoted pathogenic function of activated naïve B cells of patients with SLE
Wangriatisak K, Kochayoo P, Thawornpan P, Leepiyasakulchai C, Suangtamai T, Ngamjanyaporn P, Khowawisetsut L, Khaenam P, Pisitkun P, Chootong P |
Lupus Science & Medicine | 2022 |
Aberrant B Cell Signaling in Autoimmune Diseases
Corneth OB, Neys SF, Hendriks RW |
Cells | 2022 |
Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies
Carreón-Talavera R, Santana-Sánchez P, Fuentes-Pananá EM, Legorreta-Haquet MV, Chávez-Sánchez L, Gorocica-Rosete PS, Chávez-Rueda AK |
Frontiers in immunology | 2022 |
IL-4-induced quiescence of resting naïve B cells is disrupted in systemic lupus erythematosus
Gao M, Liu S, Chatham WW, Mountz JD, Hsu HC |
Journal of immunology (Baltimore, Md. : 1950) | 2022 |
Meant to B: B cells as a therapeutic target in Systemic Lupus Erythematosus
Yemil Atisha-Fregoso, Bahtiyar Toz, Betty Diamond |
Journal of Clinical Investigation | 2021 |
B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus
SA Jenks, C Wei, R Bugrovsky, A Hill, X Wang, FM Rossi, K Cashman, MC Woodruff, LD Aspey, SS Lim, G Bao, C Drenkard, I Sanz |
Annals of the rheumatic diseases | 2021 |
Helper T Cells in Idiopathic Membranous Nephropathy
Q Zhao, H Dai, X Liu, H Jiang, W Liu, Z Feng, N Zhang, Y Gao, Z Dong, X Zhou, J Du, N Zhang, H Rui, L Yuan, B Liu |
Frontiers in immunology | 2021 |
Regulation of B Cell Responses in SLE by Three Classes of Interferons
PP Domeier, ZS Rahman |
International journal of molecular sciences | 2021 |
Human transitional and IgM low mature naïve B cells preserve permissive B‐cell receptors
Z Zhang, CJ Jara, M Singh, H Xu, CC Goodnow, KJ Jackson, JH Reed |
Immunology and Cell Biology | 2021 |
Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen–Driven Antibody-Forming Cell and Germinal Center Responses
SL Schell, KN Bricker, AJ Fike, SB Chodisetti, PP Domeier, NM Choi, MJ Fasnacht, SA Luckenbill, SF Ziegler, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
Serine/Threonine phosphatase PP2A is essential for optimal B cell function
Esra Meidan, Hao Li, Wenliang Pan, Michihito Kono, Shuilian Yu, Vasileios C. Kyttaris, Christina Ioannidis, Noe Rodríguez-Rodríguez, Jose C. Crispin, Sokratis A. Apostolidis, Pui Y. Lee, John Manis, Amir Sharabi, Maria Tsokos, George C. Tsokos |
JCI Insight | 2020 |
Primary vitreoretinal lymphomas display a remarkably restricted immunoglobulin gene repertoire
N Belhouachi, A Xochelli, M Boudjoghra, C Lesty, N Cassoux, C Fardeau, TH Tran, S Choquet, B Sarker, C Houillier, A Alentorn, P LeHoang, C Soussain, V Touitou, H Merle-Beral, K Hoang-Xuan, B Bodaghi, K Stamatopoulos, F Davi |
Blood Advances | 2020 |
In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells
GJ Cowan, K Miles, L Capitani, SS Giguere, H Johnsson, C Goodyear, IB McInnes, S Breusch, D Gray, M Gray |
Frontiers in immunology | 2020 |
Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies
DG Efremov, S Turkalj, L Laurenti |
Cancers | 2020 |
Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity
SB Chodisetti, AJ Fike, PP Domeier, H Singh, NM Choi, C Corradetti, YI Kawasawa, TK Cooper, R Caricchio, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
Intermittent Fasting Aggravates Lupus Nephritis through Increasing Survival and Autophagy of Antibody Secreting Cells in MRL/lpr Mice
SM Hong, J Lee, SG Jang, Y Song, M Kim, J Lee, ML Cho, SK Kwok, SH Park |
International journal of molecular sciences | 2020 |
Homeostasis and regulation of autoreactive B cells
S Lee, Y Ko, TJ Kim |
Cellular and Molecular Immunology | 2020 |
Humoral immune responses: Unsung heroes of the war on cancer
JR Conejo-Garcia, S Biswas, R Chaurio |
Seminars in Immunology | 2020 |
Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development
SB Chodisetti, AJ Fike, PP Domeier, SL Schell, TE Mockus, NM Choi, C Corradetti, B Hou, HM Atkins, R Caricchio, T Decker, AE Lukacher, N Olsen, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
Belimumab and Rituximab in Systemic Lupus Erythematosus: A Tale of Two B Cell-Targeting Agents
LM Wise, W Stohl |
Frontiers in Medicine | 2020 |
Prognostic value of immune related genes in lung adenocarcinoma
Wang H, Wang MS, Wang Y, Huang YQ, Shi JP, Ding ZL, Wang WJ |
Oncology Letters | 2020 |
Understanding and measuring human B‐cell tolerance and its breakdown in autoimmune disease
KS Cashman, SA Jenks, MC Woodruff, D Tomar, CM Tipton, CD Scharer, FE Lee, JM Boss, I Sanz |
Immunological Reviews | 2019 |
Pathogenic B‐cell receptor signaling in lymphoid malignancies: New insights to improve treatment
RM Young, JD Phelan, WH Wilson, LM Staudt |
Immunological Reviews | 2019 |
Functional Characterization of CD11c + Age-Associated B Cells as Memory B Cells
SW Du, T Arkatkar, FA Qureshah, HM Jacobs, CD Thouvenel, K Chiang, AD Largent, QZ Li, B Hou, DJ Rawlings, SW Jackson |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
Failure of B Cell Tolerance in CVID
CT Richardson, MA Slack, G Dhillon, CZ Marcus, J Barnard, A Palanichamy, I Sanz, RJ Looney, JH Anolik |
Frontiers in immunology | 2019 |
BAFF inhibition in SLE—Is tolerance restored?
SW Jackson, A Davidson |
Immunological Reviews | 2019 |
Autoreactive B cells in SLE, villains or innocent bystanders?
JA Hamilton, HC Hsu, JD Mountz |
Immunological Reviews | 2019 |
Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations
I Sanz, C Wei, SA Jenks, KS Cashman, C Tipton, MC Woodruff, J Hom, FE Lee |
Frontiers in immunology | 2019 |
Self‐reactivity on a spectrum: A sliding scale of peripheral B cell tolerance
C Tan, M Noviski, J Huizar, J Zikherman |
Immunological Reviews | 2019 |
Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients
Weiqing Huang, tam quach, Cosmin Dascalu, Zheng Liu, Tungming Leung, Miranda Byrne-Steele, Wenjing Pan, Qunying Yang, Jian Han, Martin L. Lesser, Thomas Rothstein, Richard Furie, Meggan Mackay, Cynthia Aranow, Anne Davidson |
JCI Insight | 2018 |
Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus
S Malkiel, AN Barlev, Y Atisha-Fregoso, J Suurmond, B Diamond |
Frontiers in immunology | 2018 |
Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach
CM Tipton, JR Hom, CF Fucile, AF Rosenberg, I Sanz |
Immunological Reviews | 2018 |
Loss of an IgG plasma cell checkpoint in patients with lupus
J Suurmond, Y Atisha-Fregoso, E Marasco, AN Barlev, N Ahmed, SA Calderon, MY Wong, MC Mackay, C Aranow, B Diamond |
Journal of Allergy and Clinical Immunology | 2018 |
Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes
KL Good-Jacobson, JR Groom |
Frontiers in immunology | 2018 |
B cell responses to apoptotic cells in MFG-E8-/- mice
YF Peng, JC Crispin |
PloS one | 2018 |
The Interplay Between Innate-Like B Cells and Other Cell Types in Autoimmunity
GJ Tsay, M Zouali |
Frontiers in immunology | 2018 |
Role of B-cell receptors for B-cell development and antigen-induced differentiation
JC Yam-Puc, L Zhang, Y Zhang, KM Toellner |
F1000Research | 2018 |
B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells
PP Domeier, SB Chodisetti, SL Schell, YI Kawasawa, MJ Fasnacht, C Soni, ZS Rahman |
Cell Reports | 2018 |
Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients
M Liu, Q Guo, C Wu, D Sterlin, S Goswami, Y Zhang, T Li, C Bao, N Shen, Q Fu, X Zhang |
Cellular and Molecular Immunology | 2018 |
Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes
A Miyagawa-Hayashino, H Yoshifuji, K Kitagori, S Ito, T Oku, Y Hirayama, A Salah, T Nakajima, K Kiso, N Yamada, H Haga, T Tsuruyama |
Arthritis Research & Therapy | 2018 |
Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance
M Noviski, J Zikherman |
Current Opinion in Immunology | 2018 |
The role of B cells in multiple sclerosis: current and future therapies
A Negron, RR Robinson, O Stuve, TG Forsthuber |
Cellular Immunology | 2018 |
Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study
B Šumová, LA Cerezo, L Szczuková, L Nekvindová, M Uher, H Hulejová, R Moravcová, M Grigorian, K Pavelka, J Vencovský, L Šenolt, J Závada |
Rheumatology International | 2018 |
Altered B cell signalling in autoimmunity
DJ Rawlings, G Metzler, M Wray-Dutra, SW Jackson |
Nature Reviews Immunology | 2017 |
Identification of autoreactive B cells with labeled nucleosomes
V Gies, A Wagner, C Seifert, A Guffroy, JD Fauny, AM Knapp, JL Pasquali, T Martin, H Dumortier, AS Korganow, P Soulas-Sprauel |
Scientific Reports | 2017 |
Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria
JN Schickel, S Glauzy, YS Ng, N Chamberlain, C Massad, I Isnardi, N Katz, G Uzel, SM Holland, C Picard, A Puel, JL Casanova, E Meffre |
Journal of Experimental Medicine | 2017 |
Immunological tolerance as a barrier to protective HIV humoral immunity
KM Schroeder, A Agazio, RM Torres |
Current Opinion in Immunology | 2017 |
Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation
R Catera, Y Liu |
Molecular Medicine | 2017 |
Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity
P Hemon, Y Renaudineau, M Debant, NL Goux, S Mukherjee, W Brooks, O Mignen |
Clinical Reviews in Allergy & Immunology | 2017 |
Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus
JH Reed, MK Gorny, L Li, T Cardozo, JP Buyon, RM Clancy |
Journal of Autoimmunity | 2017 |
Self-dsDNA in the pathogenesis of systemic lupus erythematosus: Self-dsDNA in SLE
Y Bai, Y Tong, Y Liu, H Hu |
Clinical & Experimental Immunology | 2017 |
Phenotyping of autoreactive B cells with labeled nucleosomes in 56R transgenic mice
V Gies, D Bouis, M Martin, JL Pasquali, T Martin, AS Korganow, P Soulas-Sprauel |
Scientific Reports | 2017 |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
WB Williams, J Zhang, C Jiang, NI Nicely, D Fera, K Luo, MA Moody, HX Liao, SM Alam, TB Kepler, A Ramesh, K Wiehe, JA Holland, T Bradley, N Vandergrift, KO Saunders, R Parks, A Foulger, SM Xia, M Bonsignori, DC Montefiori, M Louder, A Eaton, S Santra, R Scearce, L Sutherland, A Newman, H Bouton-Verville, C Bowman, H Bomze, F Gao, DJ Marshall, JF Whitesides, X Nie, G Kelsoe, SG Reed, CB Fox, K Clary, M Koutsoukos, D Franco, JR Mascola, SC Harrison, BF Haynes, L Verkoczy |
Nature Communications | 2017 |
TLR7, a third signal for the robust generation of spontaneous germinal center B cells in systemic lupus erythematosus
H Fan, D Ren, Y Hou |
Cellular and Molecular Immunology | 2017 |
PKK deficiency in B cells prevents lupus development in Sle lupus mice
D Oleksyn, J Zhao, A Vosoughi, JC Zhao, R Misra, AP Pentland, D Ryan, J Anolik, C Ritchlin, J Looney, AP Anandarajah, G Schwartz, LM Calvi, M Georger, C Mohan, I Sanz, L Chen |
Immunology Letters | 2017 |
Current and future therapies for SLE: obstacles and recommendations for the development of novel treatments
Z Touma, DD Gladman |
Lupus Science & Medicine | 2017 |
Expression of CCR6 on B cells in systemic lupus erythematosus patients
AY Lee, JL Bannan, MJ Adams, H Körner |
Clinical Rheumatology | 2017 |
Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization
JH Reed, J Jackson, D Christ, CC Goodnow |
Journal of Experimental Medicine | 2016 |
Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch
DT MacLeod, NM Choi, B Briney, F Garces, LS Ver, E Landais, B Murrell, T Wrin, W Kilembe, CH Liang, A Ramos, CB Bian, L Wickramasinghe, L Kong, K Eren, CY Wu, CH Wong, SL Pond, IA Wilson, DR Burton, P Poignard |
Immunity | 2016 |
The Regulation of Inherently Autoreactive VH4-34–Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa
GT Hart, M Akkaya, AS Chida, C Wei, SA Jenks, C Tipton, C He, BS Wendel, J Skinner, G Arora, K Kayentao, A Ongoiba, O Doumbo, B Traore, DL Narum, N Jiang, PD Crompton, I Sanz, SK Pierce |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Regulatorische T‑Zellen beim systemischen Lupus erythematodes: IL-2 entscheidend für Verlust der Toleranz
K Ohl, K Tenbrock |
Zeitschrift für Rheumatologie | 2016 |
DNA-reactive B cells in lupus
J Suurmond, J Calise, S Malkiel, B Diamond |
Current Opinion in Immunology | 2016 |
IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity
PP Domeier, SB Chodisetti, C Soni, SL Schell, MJ Elias, EB Wong, TK Cooper, D Kitamura, ZS Rahman |
Journal of Experimental Medicine | 2016 |
Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool
R Appanna, S KG, MH Xu, YX Toh, S Velumani, D Carbajo, CY Lee, R Zuest, T Balakrishnan, W Xu, B Lee, M Poidinger, F Zolezzi, YS Leo, TL Thein, CI Wang, K Fink |
EBioMedicine | 2016 |
ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells
CD Scharer, EL Blalock, BG Barwick, RR Haines, C Wei, I Sanz, JM Boss |
Scientific Reports | 2016 |
Increased frequency of thymic T follicular helper cells in myasthenia gravis patients with thymoma
Y Song, L Zhou, F Miao, G Chen, Y Zhu, X Gao, Y Wang, L Pang, C Zhao, X Sun, Z Chen |
Journal of Thoracic Disease | 2016 |
The Effect of BAFF Inhibition on Autoreactive B-Cell Selection in Murine Systemic Lupus Erythematosus
A Boneparth, M Woods |
Molecular Medicine | 2016 |
Spontaneous germinal centers and autoimmunity
PP Domeier, SL Schell, ZS Rahman |
Autoimmunity | 2016 |
Germinal centers and autoimmune disease in humans and mice
AL DeFranco |
Immunology and Cell Biology | 2016 |
IgD attenuates the IgM-induced anergy response in transitional and mature B cells
Z Sabouri, S Perotti, E Spierings, P Humburg, M Yabas, H Bergmann, K Horikawa, C Roots, S Lambe, C Young, TD Andrews, M Field, A Enders, JH Reed, CC Goodnow |
Nature Communications | 2016 |
The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases
LA Garrett-Sinha, A Kearly, AB Satterthwaite |
Critical reviews in immunology | 2016 |
High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination
K Kaur, NY Zheng, K Smith, M Huang, L Li, NT Pauli, CJ Dunand, JH Lee, M Morrissey, Y Wu, ML Joachims, ME Munroe, D Lau, X Qu, F Krammer, J Wrammert, P Palese, R Ahmed, JA James, PC Wilson, F Rieux-Laucat |
PloS one | 2015 |
Anergic B Cells: Precarious On-Call Warriors at the Nexus of Autoimmunity and False-Flagged Pathogens
AJ Rosenspire, K Chen |
Frontiers in immunology | 2015 |
Polychromatic flow cytometry in evaluating rheumatic disease patients
C Wei, S Jenks, I Sanz |
Arthritis Research & Therapy | 2015 |
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
CM Tipton, CF Fucile, J Darce, A Chida, T Ichikawa, I Gregoretti, S Schieferl, J Hom, S Jenks, RJ Feldman, R Mehr, C Wei, FE Lee, WC Cheung, AF Rosenberg, I Sanz |
Nature Immunology | 2015 |
Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
NS Kolhatkar, A Brahmandam, CD Thouvenel, S Becker-Herman, HM Jacobs, MA Schwartz, EJ Allenspach, S Khim, AK Panigrahi, ET Prak, AJ Thrasher, LD Notarangelo, F Candotti, TR Torgerson, I Sanz, DJ Rawlings |
Journal of Experimental Medicine | 2015 |
B Cells, Antibodies, and More
W Hoffman, FG Lakkis, G Chalasani |
Clinical journal of the American Society of Nephrology : CJASN | 2015 |
Defects in Germinal Center Selection in SLE
M Woods, YR Zou, A Davidson |
Frontiers in immunology | 2015 |
Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity: Circulating Tfh-Like Cells in SLE
JY Choi, JH Ho, SG Pasoto, V Bunin, ST Kim, S Carrasco, EF Borba, CR Gonçalves, PR Costa, EG Kallas, E Bonfa, J Craft |
Arthritis & Rheumatology | 2015 |
B Cell-Intrinsic CD84 and Ly108 Maintain Germinal Center B Cell Tolerance
EB Wong, C Soni, AY Chan, PP Domeier, Shwetank, T Abraham, N Limaye, TN Khan, MJ Elias, SB Chodisetti, EK Wakeland, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding VH81X-expressing B cells
O Grimsholm, W Ren, AI Bernardi, H Chen, G Park, A Camponeschi, D Chen, B Bergmann, N Höök, S Andersson, A Strömberg, I Gjertsson, S Cardell, U Yrlid, AD Riva, IL Mårtensson |
Nature Communications | 2015 |
Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
K Ma, J Li, Y Fang, L Lu |
International journal of molecular sciences | 2015 |
Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus
D Ren, F Liu, G Dong, M You, J Ji, Y Huang, Y Hou, H Fan |
Cellular and Molecular Immunology | 2015 |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
YR Li, J Li, SD Zhao, JP Bradfield, FD Mentch, SM Maggadottir, C Hou, DJ Abrams, D Chang, F Gao, Y Guo, Z Wei, JJ Connolly, CJ Cardinale, M Bakay, JT Glessner, D Li, C Kao, KA Thomas, H Qiu, RM Chiavacci, CE Kim, F Wang, J Snyder, MD Richie, B Flatø, Ø Førre, LA Denson, SD Thompson, ML Becker, SL Guthery, A Latiano, E Perez, E Resnick, RK Russell, DC Wilson, MS Silverberg, V Annese, BA Lie, M Punaro, MC Dubinsky, DS Monos, C Strisciuglio, A Staiano, E Miele, S Kugathasan, JA Ellis, JE Munro, KE Sullivan, CA Wise, H Chapel, C Cunningham-Rundles, SF Grant, JS Orange, PM Sleiman, EM Behrens, AM Griffiths, J Satsangi, TH Finkel, A Keinan, ET Prak, C Polychronakos, RN Baldassano, H Li, BJ Keating, H Hakonarson |
Nature Medicine | 2015 |
Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis
A Thiel, G Yavanian, MD Nastke, P Morales, NA Kouris, EA Kimbrel, R Lanza |
Scientific Reports | 2015 |
OX40/OX40L axis: not a friend in autoimmunity
H Ueno, P Blanco |
Oncotarget | 2015 |
Rationale for B cell targeting in SLE
I Sanz |
Seminars in Immunopathology | 2014 |
Chronic lymphocytic leukaemia: could immunological tolerance mechanisms be the origin of lymphoid neoplasms?
R García-Muñoz, L Llorente |
Immunology | 2014 |
Expression of the Inherently Autoreactive Idiotope 9G4 on Autoantibodies to Citrullinated Peptides and on Rheumatoid Factors in Patients with Early and Established Rheumatoid Arthritis
G Cambridge, RA Moura, T Santos, AA Khawaja, J Polido-Pereira, H Canhão, MJ Leandro, JE Fonseca, P Szodoray |
PloS one | 2014 |
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, D Langley, B Roome, R Vazquez-Lombardi, R Rouet, J Hermes, TD Chan, R Brink, DK Dunn-Walters, D Christ, CC Goodnow |
Proceedings of the National Academy of Sciences | 2014 |
Germinal Center B Cell Depletion Diminishes CD4+ Follicular T Helper Cells in Autoimmune Mice
I Yusuf, J Stern, TM McCaughtry, S Gallagher, H Sun, C Gao, T Tedder, G Carlesso, L Carter, R Herbst, Y Wang |
PloS one | 2014 |
Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome
E Corsiero, N Sutcliffe, C Pitzalis, M Bombardieri, J Reddy |
PloS one | 2014 |
B Cell-Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers
C Soni, EB Wong, PP Domeier, TN Khan, T Satoh, S Akira, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis
J Vas, C Grönwall, GJ Silverman |
Frontiers in immunology | 2013 |
9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus
SA Jenks, EM Palmer, EY Marin, L Hartson, AS Chida, C Richardson, I Sanz |
Arthritis & Rheumatism | 2013 |
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
C Richardson, AS Chida, D Adlowitz, L Silver, E Fox, SA Jenks, E Palmer, Y Wang, J Heimburg-Molinaro, QZ Li, C Mohan, R Cummings, C Tipton, I Sanz |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles
DC Alcéna, JJ Kobie, DA Kaminski, AF Rosenberg, JL Mattiacio, M Brewer, S Dewhurst, C Dykes, X Jin, MC Keefer, I Sanz |
PloS one | 2013 |
Protein Kinase Cβ Is Required for Lupus Development in Sle Mice
D Oleksyn, M Pulvino, J Zhao, R Misra, A Vosoughi, S Jenks, C Tipton, F Lund, G Schwartz, B Goldman, C Mohan, K Mehta, M Mehta, M Leitgets, I Sanz, L Chen |
Arthritis & Rheumatism | 2013 |
Contributions of B cells to lupus pathogenesis
A Sang, YY Zheng, L Morel |
Molecular Immunology | 2013 |
Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs
A Renand, P Milpied, J Rossignol, J Bruneau, F Lemonnier, M Dussiot, S Coulon, O Hermine |
PloS one | 2013 |
Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses
RA Sweet, JL Cullen, MJ Shlomchik |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
Development of autoantibodies due to regulator of G-protein signaling 13-induced delay in Germinal center B cell differentiation to plasmablasts: RGS13 Induces Germinal Center Program Extension
JH Wang, JS New, S Xie, PA Yang, Q Wu, J Li, B Luo, Y Ding, KM Druey, HC Hsu, JD Mountz |
2013 | |
Expansion of HIV-specific T follicular helper cells in chronic HIV infection
Madelene Lindqvist, Jan van Lunzen, Damien Soghoian, Bjorn Kuhl, Srinika Ranasinghe, Gregory Kranias, Michael Flanders, Sam Cutler, Naomi Yudanin, Matthias Muller, Isaiah Davis, Donna Farber, Philip Hartjen, Friedrich Haag, Galit Alter, Julian Schulze Zur Wiesch, Hendrik Streeck |
Journal of Clinical Investigation | 2012 |
Autoimmunity
A Perl |
Autoimmunity | 2012 |
Immunological aspects in chronic lymphocytic leukemia (CLL) development
R García-Muñoz, VR Galiacho, L Llorente |
Annals of Hematology | 2012 |
Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation
H Joo, C Coquery, Y Xue, I Gayet, SR Dillon, M Punaro, G Zurawski, J Banchereau, V Pascual, S Oh |
Journal of Experimental Medicine | 2012 |
9G4 Autoreactivity Is Increased in HIV-Infected Patients and Correlates with HIV Broadly Neutralizing Serum Activity
JJ Kobie, DC Alcena, B Zheng, P Bryk, JL Mattiacio, M Brewer, C Labranche, FM Young, S Dewhurst, DC Montefiori, AF Rosenberg, C Feng, X Jin, MC Keefer, I Sanz |
PloS one | 2012 |
Antibody Repertoires in Humanized NOD-scid-IL2Rγnull Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse
GC Ippolito, KH Hoi, ST Reddy, SM Carroll, X Ge, T Rogosch, M Zemlin, LD Shultz, AD Ellington, CL Vandenberg, G Georgiou |
PloS one | 2012 |
Advances in human B cell phenotypic profiling
DA Kaminski, C Wei, Y Qian, AF Rosenberg, I Sanz |
Frontiers in immunology | 2012 |
Follicular helper T cells in immunity and systemic autoimmunity
JE Craft |
Nature reviews. Rheumatology | 2012 |
Taming lupus-a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson |
Nature Medicine | 2012 |
The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner
EB Wong, TN Khan, C Mohan, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
Regulation of Humoral Immunity by Complement
MC Carroll, DE Isenman |
Immunity | 2012 |
Treatment targets in systemic lupus erythematosus: biology and clinical perspective
V Marian, JH Anolik |
Arthritis Research & Therapy | 2012 |
The darker side of follicular helper T cells: from autoimmunity to immunodeficiency
S Shekhar, X Yang |
Cellular and Molecular Immunology | 2012 |
Resolve, revise, and relax: The 3 Rs of B cell repertoire adjustment
JL Scholz, MP Cancro |
Immunology Letters | 2012 |
T Cells That Promote B-Cell Maturation in Systemic Autoimmunity
JS Weinstein, SG Hernandez, J Craft |
Immunological Reviews | 2012 |
The pathogenesis of systemic lupus erythematosus-an update
J Choi, ST Kim, J Craft |
Current Opinion in Immunology | 2012 |
The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY
MV Sasidhar, N Itoh, SM Gold, GW Lawson, RR Voskuhl |
Annals of the rheumatic diseases | 2012 |
B Cell Tolerance and Positive Selection in Lupus
D Eilat, M Wabl |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
J Glanville, TC Kuo, HC Büdingen, L Guey, J Berka, PD Sundar, G Huerta, GR Mehta, JR Oksenberg, SL Hauser, DR Cox, A Rajpal, J Pons |
Proceedings of the National Academy of Sciences | 2011 |
Anergic Responses Characterize a Large Fraction of Human Autoreactive Naive B Cells Expressing Low Levels of Surface IgM
TD Quach, N Manjarrez-Orduno, DG Adlowitz, L Silver, H Yang, C Wei, EC Milner, I Sanz |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
F Hiepe, T Dörner, AE Hauser, BF Hoyer, H Mei, A Radbruch |
Nature Reviews Rheumatology | 2011 |
Mechanisms of B cell autoimmunity in SLE
T Dörner, C Giesecke, PE Lipsky |
Arthritis Research & Therapy | 2011 |
OMIP-003: phenotypic analysis of human memory B cells
C Wei, J Jung, I Sanz |
Cytometry Part A | 2011 |
Invariant NKT cells limit activation of autoreactive CD1d-positive B cells
F Wermeling, SM Lind, ED Jordö, SL Cardell, MC Karlsson |
Journal of Experimental Medicine | 2010 |
B-cell Biology and Related Therapies in Systemic Lupus Erythematosus
S Ahmed, JH Anolik |
Rheumatic Disease Clinics of North America | 2010 |
Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones
I Isnardi, YS Ng, L Menard, G Meyers, D Saadoun, I Srdanovic, J Samuels, J Berman, JH Buckner, C Cunningham-Rundles, E Meffre |
Blood | 2010 |
Memory B cells from a subset of treatment naïve relapsing remitting multiple sclerosis patients elicit CD4+ T cell proliferation and IFN-γ production in response to MBP and MOG
CT Harp, S Ireland, LS Davis, G Remington, B Cassidy, PD Cravens, O Stuve, AE Lovett-Racke, TN Eagar, BM Greenberg, MK Racke, LG Cowell, NJ Karandikar, EM Frohman, NL Monson |
European Journal of Immunology | 2010 |
Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment
A Perl |
Autoimmunity | 2010 |
Signals that influence T follicular helper cell differentiation and function
MA Linterman, CG Vinuesa |
Seminars in Immunopathology | 2010 |
Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients
B Rodríguez-Bayona, A Ramos-Amaya, JJ Pérez-Venegas, C Rodríguez, JA Brieva |
Arthritis Research & Therapy | 2010 |
The Ubiquitin Modifying Enayme A20 Restricts B cell Survival and Prevents Autoimmunity
RM Tavares, EE Turer, CL Liu, R Advincula, P Scapini, L Rhee, J Barrera, CA Lowell, PJ Utz, BA Malynn, A Ma |
Immunity | 2010 |
Deletion of IgG-Switched Autoreactive B Cells and Defects in Fas lpr Lupus Mice
D Aït-Azzouzene, DH Kono, R Gonzalez-Quintial, LJ McHeyzer-Williams, M Lim, D Wickramarachchi, T Gerdes, AL Gavin, P Skog, MG McHeyzer-Williams, D Nemazee, AN Theofilopoulos |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
S Sarantopoulos, KE Stevenson, HT Kim, CS Cutler, NS Bhuiya, M Schowalter, VT Ho, EP Alyea, J Koreth, BR Blazar, RJ Soiffer, JH Antin, J Ritz |
Blood | 2009 |
B Cells and Immunological Tolerance
N Manjarrez-Orduño, TD Quách, I Sanz |
Journal of Investigative Dermatology | 2009 |
Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets
JH Anolik, RJ Looney, FE Lund, TD Randall, I Sanz |
Immunologic Research | 2009 |
B cells in autoimmunity
T Dörner, AM Jacobi, PE Lipsky |
Arthritis Research & Therapy | 2009 |
The role of B cells in lupus pathogenesis
E Nashi, YH Wang, B Diamond |
The International Journal of Biochemistry & Cell Biology | 2009 |
Follicular helper T cells are required for systemic autoimmunity
MA Linterman, RJ Rigby, RK Wong, D Yu, R Brink, JL Cannons, PL Schwartzberg, MC Cook, GD Walters, CG Vinuesa |
Journal of Experimental Medicine | 2009 |
TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones
IY Hwang, C Park, K Harrison, JH Kehrl |
Journal of Experimental Medicine | 2009 |
Anti-nuclear antibody reactivity in lupus may be partly hard-wired into the primary B-cell repertoire
S Chang, L Yang, YM Moon, YG Cho, SY Min, TJ Kim, YJ Kim, W Patrick, HY Kim, C Mohan |
Molecular Immunology | 2009 |
Molecular hallmarks of anti-chromatin antibodies associated with the lupus susceptibility locus, Sle1
Z Liang, S Chang, MS Youn, C Mohan |
Molecular Immunology | 2009 |
B cells and transplantation: an educational resource
TN Small, WH Robinson, DB Miklos |
Biology of Blood and Marrow Transplantation | 2009 |
The Lupus Susceptibility Locus Sle1 Breaches Peripheral B Cell Tolerance at the Antibody-Forming Cell and Germinal Center Checkpoints
R Vuyyuru, C Mohan, T Manser, ZS Rahman |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors
JA Duty, P Szodoray, NY Zheng, KA Koelsch, Q Zhang, M Swiatkowski, M Mathias, L Garman, C Helms, B Nakken, K Smith, AD Farris, PC Wilson |
Journal of Experimental Medicine | 2008 |
Phenotypic and functional heterogeneity of human memory B cells
I Sanz, C Wei, FE Lee, J Anolik |
Seminars in Immunology | 2008 |
How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
V Pascual, F Allantaz, P Patel, AK Palucka, D Chaussabel, J Banchereau |
Immunological Reviews | 2008 |
Developments in the scientific understanding of lupus
SP Ardoin, DS Pisetsky |
Arthritis Research & Therapy | 2008 |
Role of B cells in systemic lupus erythematosus and rheumatoid arthritis
L Mandik-Nayak, N Ridge, M Fields, AY Park, J Erikson |
Current Opinion in Immunology | 2008 |
Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus
S Hillion, S Garaud, V Devauchelle, A Bordron, C Berthou, P Youinou, C Jamin |
Immunology | 2007 |
Autoreactivity in human IgG+ memory B cells
T Tiller, M Tsuiji, S Yurasov, K Velinzon, MC Nussenzweig, H Wardemann |
Immunity | 2007 |
Understanding B-cell tolerance through the use of immunoglobulin transgenic models
KR Kumar, C Mohan |
Immunologic Research | 2007 |