Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, α subunit (HIF-1α) to myeloid cell innate immune function. HIF-1α was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-α. Mice lacking HIF-1α in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus. Conversely, activation of the HIF-1α pathway through deletion of von Hippel–Lindau tumor-suppressor protein or pharmacologic inducers supported myeloid cell production of defense factors and improved bactericidal capacity. HIF-1α control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense.
Carole Peyssonnaux, Vivekanand Datta, Thorsten Cramer, Andrew Doedens, Emmanuel A. Theodorakis, Richard L. Gallo, Nancy Hurtado-Ziola, Victor Nizet, Randall S. Johnson
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Antimicrobial Resistance in ESKAPE Pathogens
DM Oliveira, BM Forde, TJ Kidd, PN Harris, MA Schembri, SA Beatson, DL Paterson, MJ Walker |
Clinical microbiology reviews | 2020 |
Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine
K Hirota |
Biomedicines | 2020 |
Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound
M Baiula, R Greco, L Ferrazzano, A Caligiana, K Hoxha, D Bandini, P Longobardi, S Spampinato, A Tolomelli, N Aykin-Burns |
PloS one | 2020 |
Replication of Salmonella enterica serovar Typhimurium in RAW264.7 Phagocytes Correlates With Hypoxia and Lack of iNOS Expression
M Wrande, K Vestö, SP Banesaru, N Anwar, J Nordfjell, L Liu, GM McInerney, M Rhen |
Frontiers in Cellular and Infection Microbiology | 2020 |
Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of “same treatment for different diseases” in traditional Chinese medicine
He RP, Jin Z, Ma RY, Hu FD, Dai JY |
Chinese Herbal Medicines | 2020 |
Epidermal hepcidin is required for neutrophil response to bacterial infection
Mariangela Malerba, Sabine Louis, Sylvain Cuvellier, Srikanth Mairpady Shambat, Camille Hua, Camille Gomart, Agnès Fouet, Nicolas Ortonne, Jean-Winoc Decousser, Annelies Sophie Zinkernagel, Jacques RR Mathieu, Carole Peyssonnaux |
Journal of Clinical Investigation | 2019 |
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell, Adrian Erlebacher |
Journal of Clinical Investigation | 2019 |
Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?
A Remot, E Doz, N Winter |
Frontiers in immunology | 2019 |
Immunometabolism and Sepsis: A Role for HIF?
SF Fitzpatrick |
Frontiers in Molecular Biosciences | 2019 |
Immunometabolic cross-talk in the inflamed heart
FM Marelli-Berg, D Aksentijevic |
2019 | |
Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis
C Scott, R Stokes, KM Cha, A Clouston, M Eslam, M Metwally, MM Swarbrick, J George, JE Gunton, MB Aguila |
PloS one | 2019 |
The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity
R Golonka, BS Yeoh, M Vijay-Kumar |
Journal of Innate Immunity | 2019 |
Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia
DS Dzhalilova, AM Kosyreva, ME Diatroptov, NA Zolotova, IS Tsvetkov, VA Mkhitarov, OV Makarova, DN Khochanskiy |
International Journal of Inflammation | 2019 |
Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization
JY Tinevez, ET Arena, M Anderson, G Nigro, L Injarabian, A André, M Ferrari, FX Campbell-Valois, A Devin, SL Shorte, PJ Sansonetti, BS Marteyn |
Nature Microbiology | 2019 |
Reassessing the Host Defense Peptide Landscape
EF Haney, SK Straus, RE Hancock |
Frontiers in Chemistry | 2019 |
The Activin Receptor, Activin-Like Kinase 4, Mediates Toxoplasma Gondii Activation of Hypoxia Inducible Factor-1
A Lis, M Wiley, J Vaughan, PC Gray, IJ Blader |
Frontiers in Cellular and Infection Microbiology | 2019 |
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
SK Daniel, KM Sullivan, KP Labadie, VG Pillarisetty |
Clinical and Translational Medicine | 2019 |
Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response
P Sadiku, SR Walmsley |
EMBO reports | 2019 |
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells
TP Chapman, D Corridoni, S Shiraishi, S Pandey, A Aulicino, S Wigfield, M do Carmo Costa, ML Thézénas, H Paulson, R Fischer, BM Kessler, A Simmons |
Frontiers in immunology | 2019 |
The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages
D Friedrich, D Zapf, B Lohse, RA Fecher, GS Deepe, J Rupp, L Pirofski |
Infection and immunity | 2019 |
Does Neutrophil Phenotype Predict the Survival of Trauma Patients?
E Mortaz, SS Zadian, M Shahir, G Folkerts, J Garssen, S Mumby, IM Adcock |
Frontiers in immunology | 2019 |
Hypoxic Regulation of Neutrophils in Cancer
D Triner, YM Shah |
International journal of molecular sciences | 2019 |
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
Z Jian, R Liu, X Zhu, D Smerin, Y Zhong, L Gu, W Fang, X Xiong |
Frontiers in immunology | 2019 |
Metabolic Insight of Neutrophils in Health and Disease
S Kumar, M Dikshit |
Frontiers in immunology | 2019 |
Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo
A Lewis, PM Elks |
Frontiers in immunology | 2019 |
Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection
M Osada-Oka, N Goda, H Saiga, M Yamamoto, K Takeda, Y Ozeki, T Yamaguchi, T Soga, Y Tateishi, K Miura, D Okuzaki, K Kobayashi, S Matsumoto |
International Immunology | 2019 |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus
NH Hajdamowicz, RC Hull, SJ Foster, AM Condliffe |
International journal of molecular sciences | 2019 |
Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo
Q Deng, J Wei, P Zou, Y Xiao, Z Zeng, Y Shi, Y Zhan, H Zhang, B Tang, Q Zeng, R Xiao |
Oxidative medicine and cellular longevity | 2019 |
HIF-1α as a central mediator of cellular resistance to intracellular pathogens
M Knight, S Stanley |
Current Opinion in Immunology | 2019 |
Coupling Krebs cycle metabolites to signalling in immunity and cancer
DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA ONeill, EL Mills |
2018 | |
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis
J Goodwin, H Choi, M Hsieh, ML Neugent, JM Ahn, HN Hayenga, PK Singh, DB Shackelford, IK Lee, V Shulaev, S Dhar, N Takeda, J Kim |
American journal of respiratory cell and molecular biology | 2018 |
Hypoxia Signaling in Vascular Homeostasis
G Marsboom, J Rehman |
Physiology (Bethesda, Md.) | 2018 |
Leishmania donovani Activates Hypoxia Inducible Factor-1α and miR-210 for Survival in Macrophages by Downregulation of NF-κB Mediated Pro-inflammatory Immune Response
V Kumar, A Kumar, S Das, A Kumar, K Abhishek, S Verma, A Mandal, RK Singh, P Das |
Frontiers in microbiology | 2018 |
Resveratrol Acts Anti-Inflammatory and Neuroprotective in an Infant Rat Model of Pneumococcal Meningitis by Modulating the Hippocampal miRNome
KB de Queiroz, T dos Santos Fontes Pereira, MS Araújo, RS Gomez, RS Coimbra |
Molecular Neurobiology | 2018 |
Effect of Hypoxia on the Pathogenesis of Acinetobacter baumannii and Pseudomonas aeruginosa In Vitro and in Murine Experimental Models of Infection
ML Gil-Marqués, ME Pachón-Ibáñez, J Pachón, Y Smani, M Whiteley |
Infection and immunity | 2018 |
Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta
SL Maas, O Soehnlein, JR Viola |
Frontiers in immunology | 2018 |
Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium
S Simmen, J Cosin-Roger, H Melhem, N Maliachovas, M Maane, K Baebler, B Weder, C Maeyashiki, K Spanaus, M Scharl, C de Vallière, J Zeitz, SR Vavricka, M Hausmann, G Rogler, PA Ruiz |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 |
Hypoxia and hyperbaric oxygen therapy: a review
R Choudhury |
International journal of general medicine | 2018 |
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
X Meng, B Grötsch, Y Luo, KX Knaup, MS Wiesener, XX Chen, J Jantsch, S Fillatreau, G Schett, A Bozec |
Nature Communications | 2018 |
Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway
R Guan, J Wang, Z Li, M Ding, D Li, G Xu, T Wang, Y Chen, Q Yang, Z Long, Z Cai, C Zhang, X Liang, L Dong, L Zhao, H Zhang, D Sun, W Lu |
Frontiers in pharmacology | 2018 |
Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss
K Hirai, H Furusho, K Hirota, H Sasaki |
International Journal of Oral Science | 2018 |
The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer
ST McSorley, CS Roxburgh, PG Horgan, DC McMillan |
Perioperative Medicine | 2018 |
Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses
D Ahmed, A Jaworski, D Roy, W Willmore, A Golshani, E Cassol |
Mediators of Inflammation | 2018 |
Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges
CY Chiang, I Uzoma, RT Moore, M Gilbert, AJ Duplantier, RG Panchal, R Rappuoli, DA Garsin |
mBio | 2018 |
Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
V Schatz, P Neubert, F Rieger, J Jantsch |
Frontiers in immunology | 2018 |
Hypoxia and acidosis: immune suppressors and therapeutic targets
S Damgaci, A Ibrahim-Hashim, PM Enriquez-Navas, S Pilon-Thomas, A Guvenis, RJ Gillies |
Immunology | 2018 |
Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells
C Domblides, L Lartigue, B Faustin |
Cells | 2018 |
Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function
HM Izquierdo, P Brandi, MJ Gómez, R Conde-Garrosa, E Priego, M Enamorado, S Martínez-Cano, I Sánchez, L Conejero, D Jimenez-Carretero, S Martín-Puig, M Guilliams, D Sancho |
Cell Reports | 2018 |
Choline transport links macrophage phospholipid metabolism and inflammation
SA Snider, KD Margison, P Ghorbani, ND LeBlond, C O'Dwyer, JR Nunes, T Nguyen, H Xu, SA Bennett, MD Fullerton |
The Journal of biological chemistry | 2018 |
Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
M Knight, J Braverman, K Asfaha, K Gronert, S Stanley, P Salgame |
PLoS pathogens | 2018 |
Hypoxia, Metabolism and Immune Cell Function
E Krzywinska, C Stockmann |
Biomedicines | 2018 |
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues
JL Ebersole, MJ Novak, L Orraca, J Martinez-Gonzalez, S Kirakodu, KC Chen, A Stromberg, OA Gonzalez |
Immunology | 2018 |
HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection
C Li, Y Wang, Y Li, Q Yu, , X Wang, A Jia, Y Hu, L Han, J Wang, H Yang, D Yan, Y Bi, G Liu |
Scientific Reports | 2018 |
Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis
CW Ong, K Fox, A Ettorre, PT Elkington, JS Friedland |
Scientific Reports | 2018 |
HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis
A Hammami, BM Abidin, KM Heinonen, S Stäger |
Scientific Reports | 2018 |
Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia
N Gupta, V Nizet |
Frontiers in Medicine | 2018 |
Gastric Aspiration and Its Role in Airway Inflammation
EB Hunt, A Sullivan, J Galvin, J MacSharry, DM Murphy |
The open respiratory medicine journal | 2018 |
Vitamin C and immune cell function in inflammation and cancer
A Ang, JM Pullar, MJ Currie, MC Vissers |
Biochemical Society Transactions | 2018 |
The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation
W Zhang, Q Li, D Li, J Li, D Aki, YC Liu |
Journal of Experimental Medicine | 2018 |
Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection
T Escajadillo, V Nizet |
Toxins | 2018 |
Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting
V Kumar |
Inflammation | 2018 |
Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
MJ Rey, Á Valín, A Usategui, CM García-Herrero, M Sánchez-Aragó, JM Cuezva, M Galindo, B Bravo, JD Cañete, FJ Blanco, G Criado, JL Pablos |
Scientific Reports | 2017 |
Energy metabolic pathways control the fate and function of myeloid immune cells
AA Al-Khami, PC Rodriguez, AC Ochoa |
Journal of leukocyte biology | 2017 |
Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo
RS Dickinson, F Murphy, C Doherty, S Williams, A Mirchandani, J Willson, JS Scotti, G Preston, CJ Schofield, MK Whyte, SR Walmsley |
Wellcome Open Research | 2017 |
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
J Cosin-Roger, S Simmen, H Melhem, K Atrott, I Frey-Wagner, M Hausmann, C Vallière, MR Spalinger, P Spielmann, RH Wenger, J Zeitz, SR Vavricka, G Rogler, PA Ruiz |
Nature Communications | 2017 |
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
SV Welden, AC Selfridge, P Hindryckx |
Nature Reviews Gastroenterology & Hepatology | 2017 |
Oxygen metabolism and innate immune responses in the gut
SP Colgan, EL Campbell |
Journal of applied physiology | 2017 |
Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil
SM Lawrence, R Corriden, V Nizet |
Frontiers in Pediatrics | 2017 |
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
G Prosser, J Brandenburg, N Reiling, CE Barry, RJ Wilkinson, KA Wilkinson |
Microbes and Infection | 2017 |
CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
S Labiano, F Meléndez-Rodríguez, A Palazón, Á Teijeira, S Garasa, I Etxeberria, MÁ Aznar, AR Sánchez-Paulete, A Azpilikueta, E Bolaños, C Molina, H la Fuente, P Maiso, F Sánchez-Madrid, MO de Landázuri, J Aragonés, I Melero |
OncoImmunology | 2017 |
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
AA Thompson, RS Dickinson, F Murphy, JP Thomson, HM Marriott, A Tavares, J Willson, L Williams, A Lewis, A Mirchandani, PD Coelho, C Doherty, E Ryan, E Watts, NM Morton, S Forbes, RH Stimson, AG Hameed, N Arnold, JA Preston, A Lawrie, V Finisguerra, M Mazzone, P Sadiku, J Goveia, F Taverna, P Carmeliet, SJ Foster, ER Chilvers, AS Cowburn, DH Dockrell, RS Johnson, RR Meehan, MK Whyte, SR Walmsley |
Science Immunology | 2017 |
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye
PJ Gardner, SE Liyanage, E Cristante, RD Sampson, AD Dick, RR Ali, JW Bainbridge |
Scientific Reports | 2017 |
Pharmacological Targeting of the Host–Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs
J Munguia, V Nizet |
Trends in Pharmacological Sciences | 2017 |
Role of AHR and HIF-1α in Glioblastoma Metabolism
G Gabriely, MA Wheeler, MC Takenaka, FJ Quintana |
Trends in Endocrinology & Metabolism | 2017 |
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis
DW Park, JW Zmijewski |
Infection & Chemotherapy | 2017 |
Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection
H Möllerherm, K Branitzki-Heinemann, G Brogden, AA Elamin, W Oehlmann, H Fuhrmann, M Singh, HY Naim, M Köckritz-Blickwede |
Frontiers in immunology | 2017 |
Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
C Gerri, R Marín-Juez, M Marass, A Marks, HM Maischein, DY Stainier |
Nature Communications | 2017 |
Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages
F Guan, XJ Lu, CH Li, J Chen, SG Lee |
PloS one | 2017 |
HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis
A Hammami, BM Abidin, T Charpentier, A Fabié, AP Duguay, KM Heinonen, S Stäger, D Sacks |
PLoS pathogens | 2017 |
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization
A Vettori, D Greenald, GK Wilson, M Peron, N Facchinello, E Markham, M Sinnakaruppan, LC Matthews, JA McKeating, F Argenton, FJ van Eeden |
Proceedings of the National Academy of Sciences | 2017 |
Pharmacological HIF-inhibition attenuates postoperative adhesion formation
MJ Strowitzki, AS Ritter, P Radhakrishnan, JM Harnoss, VM Opitz, M Biller, J Wehrmann, U Keppler, J Scheer, M Wallwiener, T Schmidt, A Ulrich, M Schneider |
Scientific Reports | 2017 |
Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB
J Braverman, SA Stanley |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus
YL Cheng, YW Wu, CF Kuo, SL Lu, FT Liu, R Anderson, CF Lin, YL Liu, WY Wang, YD Chen, PX Zheng, JJ Wu, YS Lin, JT Patton |
mBio | 2017 |
Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions
H Möllerherm, K Meier, K Schmies, H Fuhrmann, HY Naim, M Köckritz-Blickwede, K Branitzki-Heinemann |
Frontiers in immunology | 2017 |
Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection
T Schreiber, T Quinting, U Dittmer, J Fandrey, K Sutter |
Scientific Reports | 2017 |
HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
SA Santos, DR de Júnior |
Revista do Instituto de Medicina Tropical de São Paulo | 2017 |
CITED2 Restrains Proinflammatory Macrophage Activation and Response
GD Kim, R Das, X Rao, J Zhong, JA Deiuliis, DL Ramirez-Bergeron, S Rajagopalan, GH Mahabeleshwar |
Molecular and cellular biology | 2017 |
Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
D Friedrich, RA Fecher, J Rupp, GS Deepe |
Microbes and infection / Institut Pasteur | 2017 |
METABOLIC INFLAMMATORY COMPLEX IN SEPSIS: SEPTIC CACHEXIA AS A NOVEL POTENTIAL THERAPEUTIC TARGET
Kaneki M |
Shock (Augusta, Ga.) | 2017 |
Hypoxia-dependent regulation of inflammatory pathways in immune cells
Cormac Taylor, Glen Doherty, Padraic Fallon, Eoin Cummins |
Journal of Clinical Investigation | 2016 |
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Nan Lin, M. Celeste Simon |
Journal of Clinical Investigation | 2016 |
Neutrophils and the inflammatory tissue microenvironment in the mucosa
EL Campbell, DJ Kao, SP Colgan |
Immunological Reviews | 2016 |
Immunologic Consequences of Hypoxia during Critical Illness:
HD Kiers, GJ Scheffer, JG van der Hoeven, HK Eltzschig, P Pickkers, M Kox |
Anesthesiology | 2016 |
Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils
L Vollger, K Akong-Moore, L Cox, O Goldmann, Y Wang, ST Schafer, HY Naim, V Nizet, M Kockritz-Blickwede |
Bioscience Reports | 2016 |
Metabolic Factors that Contribute to Lupus Pathogenesis
W Li, R Sivakumar, AA Titov, SC Choi, L Morel |
Critical reviews in immunology | 2016 |
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases
A Egners, M Erdem, T Cramer |
Mediators of Inflammation | 2016 |
Inverse Correlation between IL-10 and HIF-1 in Macrophages Infected with Histoplasma capsulatum
RA Fecher, MC Horwath, D Friedrich, J Rupp, GS Deepe |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Macrophages and Iron Metabolism
MP Soares, I Hamza |
Immunity | 2016 |
Hypoxia and tissue destruction in pulmonary TB
M Belton, S Brilha, R Manavaki, F Mauri, K Nijran, YT Hong, NH Patel, M Dembek, L Tezera, J Green, R Moores, F Aigbirhio, A Al-Nahhas, TD Fryer, PT Elkington, JS Friedland |
Thorax | 2016 |
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1 expression
R Jones, KE McDonald, JA Willson, B Ghesquiere, D Sammut, E Daniel, AJ Harris, A Lewis, AA Thompson, RS Dickinson, T Plant, F Murphy, P Sadiku, BG Keevil, P Carmeliet, MK Whyte, J Newell-Price, SR Walmsley |
Blood | 2016 |
Mincle Signaling Promotes Con A Hepatitis
SH Greco, A Torres-Hernandez, A Kalabin, C Whiteman, R Rokosh, S Ravirala, A Ochi, J Gutierrez, MA Salyana, VR Mani, SV Nagaraj, M Deutsch, L Seifert, D Daley, R Barilla, M Hundeyin, Y Nikifrov, K Tejada, BE Gelb, SC Katz, G Miller |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
H Semba, N Takeda, T Isagawa, Y Sugiura, K Honda, M Wake, H Miyazawa, Y Yamaguchi, M Miura, DM Jenkins, H Choi, J Kim, M Asagiri, AS Cowburn, H Abe, K Soma, K Koyama, M Katoh, K Sayama, N Goda, RS Johnson, I Manabe, R Nagai, I Komuro |
Nature Communications | 2016 |
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors
E Miraglia, F Nylén, K Johansson, E Arnér, M Cebula, S Farmand, H Ottosson, R Strömberg, GH Gudmundsson, B Agerberth, P Bergman |
Scientific Reports | 2016 |
Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps
H Möllerherm, M Köckritz-Blickwede, K Branitzki-Heinemann |
Frontiers in immunology | 2016 |
Immunometabolism in Tuberculosis
L Shi, EA Eugenin, S Subbian |
Frontiers in immunology | 2016 |
HIF-1 Is an Essential Mediator of IFN- -Dependent Immunity to Mycobacterium tuberculosis
J Braverman, KM Sogi, D Benjamin, DK Nomura, SA Stanley |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
L Huynh, A Kusnadi, SH Park, K Murata, KH Park-Min, LB Ivashkiv |
Scientific Reports | 2016 |
Hypoxia and its implications in rheumatoid arthritis
CM Quiñonez-Flores, SA González-Chávez, C Pacheco-Tena |
Journal of Biomedical Science | 2016 |
The impact of inflammation on respiratory plasticity
AD Hocker, JA Stokes, FL Powell, AG Huxtable |
Experimental Neurology | 2016 |
Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia
VI Holden, P Breen, S Houle, CM Dozois, MA Bachman |
mBio | 2016 |
Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans
KE Basaran, M Villongco, B Ho, E Ellis, R Zarndt, J Antonova, SR Hopkins, FL Powell, HK Eltzschig |
PloS one | 2016 |
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis
S Dehn, M DeBerge, XY Yeap, L Yvan-Charvet, D Fang, HK Eltzschig, SD Miller, EB Thorp |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
BR Wilson, AR Bogdan, M Miyazawa, K Hashimoto, Y Tsuji |
Trends in Molecular Medicine | 2016 |
Formation of Neutrophil Extracellular Traps under Low Oxygen Level
K Branitzki-Heinemann, H Möllerherm, L Völlger, DM Husein, N Buhr, S Blodkamp, F Reuner, G Brogden, HY Naim, M Köckritz-Blickwede |
Frontiers in immunology | 2016 |
The complexities of bacterial-fungal interactions in the mammalian gastrointestinal tract
E Lopez-Medina, AY Koh |
Microbial Cell | 2016 |
Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence
CH Kowalski, SR Beattie, KK Fuller, EA McGurk, YW Tang, TM Hohl, JJ Obar, RA Cramer |
mBio | 2016 |
Myeloid Cell–Derived HIF-1α Promotes Control of Leishmania major
V Schatz, Y Strüssmann, A Mahnke, G Schley, M Waldner, U Ritter, J Wild, C Willam, N Dehne, B Brüne, JM McNiff, OR Colegio, C Bogdan, J Jantsch |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Bacterial Evasion of Host Antimicrobial Peptide Defenses
Cole JN, Nizet V |
Microbiology spectrum | 2016 |
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
HS Koh, CY Chang, SB Jeon, HJ Yoon, YH Ahn, HS Kim, IH Kim, SH Jeon, RS Johnson, EJ Park |
Nature Communications | 2015 |
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection
AE Lin, FC Beasley, J Olson, N Keller, RA Shalwitz, TJ Hannan, SJ Hultgren, V Nizet, KJ Satchell |
PLoS pathogens | 2015 |
M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling
WJ Lee, S Tateya, AM Cheng, N Rizzo-DeLeon, NF Wang, P Handa, CL Wilson, AW Clowes, IR Sweet, K Bomsztyk, MW Schwartz, F Kim |
Diabetes | 2015 |
Atelectasis causes alveolar hypoxia-induced inflammation during uneven mechanical ventilation in rats
K Tojo, Y Nagamine, T Yazawa, T Mihara, Y Baba, S Ota, T Goto, K Kurahashi |
Intensive Care Medicine Experimental | 2015 |
Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa
EL Campbell, SP Colgan |
Journal of leukocyte biology | 2015 |
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
M Schneider, JM Harnoss, MJ Strowitzki, P Radhakrishnan, L Platzer, JC Harnoss, T Hank, J Cai, A Ulrich |
Hypoxia | 2015 |
NF-κB and HIF crosstalk in immune responses
L D'Ignazio, D Bandarra, S Rocha |
FEBS Journal | 2015 |
Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens
CN LaRock, V Nizet |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2015 |
HIF-1 and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
A Tawakol, P Singh, M Mojena, M Pimentel-Santillana, H Emami, M MacNabb, JH Rudd, J Narula, JA Enriquez, PG Traves, M Fernandez-Velasco, R Bartrons, P Martin-Sanz, ZA Fayad, A Tejedor, L Bosca |
Arteriosclerosis, thrombosis, and vascular biology | 2015 |
The Ischemic Environment Drives Microglia and Macrophage Function
S Fumagalli, C Perego, F Pischiutta, ER Zanier, MG Simoni |
Frontiers in neurology | 2015 |
Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit
S Bozonet, A Carr, J Pullar, M Vissers |
Nutrients | 2015 |
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
B Kelly, LA O'Neill |
Cell Research | 2015 |
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
D Fan, LA Coughlin, MM Neubauer, J Kim, MS Kim, X Zhan, TR Simms-Waldrip, Y Xie, LV Hooper, AY Koh |
Nature Medicine | 2015 |
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
A Hammami, T Charpentier, M Smans, S Stäger, EY Denkers |
PLoS pathogens | 2015 |
Proteolytic Cleavage of AMPK and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1 Expression in Leukocytes
Z Zhang, LF Amorosa, SM Coyle, MA Macor, SE Lubitz, JL Carson, MJ Birnbaum, LY Lee, B Haimovich |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
Hypoxia-inducible factors regulate T cell metabolism and function
AT Phan, AW Goldrath |
Molecular Immunology | 2015 |
Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas
MS Cardoso, TM Silva, M Resende, R Appelberg, M Borges, S Ehrt |
Infection and immunity | 2015 |
Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
PM Elks, SA Renshaw, AH Meijer, SR Walmsley, FJ van Eeden |
Disease models & mechanisms | 2015 |
Hypoxia promotes Mycobacterium tuberculosis-specific up-regulation of granulysin in human T cells
SF Zenk, M Vollmer, E Schercher, S Kallert, J Kubis, S Stenger |
Medical Microbiology and Immunology | 2015 |
Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection
Wagage S, Hunter CA |
Current medicinal chemistry | 2015 |
Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib
HS Jun, DA Weinstein, YM Lee, BC Mansfield, JY Chou |
Blood | 2014 |
Macrophage-mediated response to hypoxia in disease
C Murdoch, S Tazzyman, J Harrison, J Yeomans, M Muthana |
Hypoxia | 2014 |
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
HK Eltzschig, DL Bratton, SP Colgan |
Nature Reviews Drug Discovery | 2014 |
Metabolic Regulation of Immune Responses
K Ganeshan, A Chawla |
Annual Review of Immunology | 2014 |
Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess
J Pacheco-Yepez, RA Jarillo-Luna, M Gutierrez-Meza, E Abarca-Rojano, BA Larsen, R Campos-Rodriguez |
BioMed Research International | 2014 |
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases
T Bhandari, V Nizet |
Infectious Diseases and Therapy | 2014 |
Orchestration of Angiogenesis by Immune Cells
A Bruno, A Pagani, L Pulze, A Albini, K Dallaglio, DM Noonan, L Mortara |
Frontiers in Oncology | 2014 |
Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model
PM Elks, M der Vaart, V Hensbergen, E Schutz, MJ Redd, E Murayama, HP Spaink, AH Meijer |
PloS one | 2014 |
Epigenetic coordination of acute systemic inflammation: potential therapeutic targets
V Vachharajani, T Liu, CE McCall |
Expert Review of Clinical Immunology | 2014 |
Investigating the real role of HIF-1 and HIF-2 in iron recycling by macrophages
JR Mathieu, M Heinis, S Zumerle, S Delga, AL Bon, C Peyssonnaux |
Haematologica | 2014 |
Metabolic Reprograming in Macrophage Polarization
S Galván-Peña, LA O’Neill |
Frontiers in immunology | 2014 |
Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection
KM Shepardson, A Jhingran, A Caffrey, JJ Obar, BT Suratt, BL Berwin, TM Hohl, RA Cramer, S Gaffen |
PLoS pathogens | 2014 |
Th1/Th2 Paradigm Extended: Macrophage Polarization as an Unappreciated Pathogen-Driven Escape Mechanism?
E Muraille, O Leo, M Moser |
2014 | |
The Regulation of Pulmonary Inflammation by the Hypoxia-Inducible Factor–Hydroxylase Oxygen-Sensing Pathway
MK Whyte, SR Walmsley |
Annals of the American Thoracic Society | 2014 |
Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia
J Harki, A Sana, D Noord, PJ van Diest, P der Groep, EJ Kuipers, LM Moons, K Biermann, ET Tjwa |
Virchows Archiv | 2014 |
HIF Transcription Factors, Inflammation, and Immunity
A Palazon, AW Goldrath, V Nizet, RS Johnson |
Immunity | 2014 |
Bile Acids Repress Hypoxia-Inducible Factor 1 Signaling and Modulate the Airway Immune Response
C Legendre, FJ Reen, DF Woods, MJ Mooij, C Adams, F O'Gara |
Infection and immunity | 2014 |
Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing
C Scott, J Bonner, D Min, P Boughton, R Stokes, KM Cha, SN Walters, K Maslowski, F Sierro, ST Grey, S Twigg, S McLennan, JE Gunton |
American journal of physiology. Cell physiology | 2014 |
HIF-mediated innate immune responses: cell signaling and therapeutic implications
S Walmsley, A Harris, AA Thompson, MK Whyte |
Hypoxia | 2014 |
Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages
A Mahnke, RJ Meier, V Schatz, J Hofmann, K Castiglione, U Schleicher, OS Wolfbeis, C Bogdan, J Jantsch |
Journal of Investigative Dermatology | 2014 |
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
AA Thompson, PM Elks, HM Marriott, S Eamsamarng, KR Higgins, A Lewis, L Williams, S Parmar, G Shaw, EE McGrath, F Formenti, FJ van Eeden, VL Kinnula, CW Pugh, I Sabroe, DH Dockrell, ER Chilvers, PA Robbins, MJ Percy, MC Simon, RS Johnson, SA Renshaw, MK Whyte, SR Walmsley |
Blood | 2013 |
HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium
T Eckle, K Brodsky, M Bonney, T Packard, J Han, CH Borchers, TJ Mariani, DJ Kominsky, M Mittelbronn, HK Eltzschig, AJ Vidal-Puig |
PLoS Biology | 2013 |
Redox control of inflammation in macrophages
B Brüne, N Dehne, N Grossmann, M Jung, D Namgaladze, T Schmid, A Knethen, A Weigert |
Antioxidants & Redox Signaling | 2013 |
Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells
A Walczak-Drzewiecka, A Salkowska, M Ratajewski, J Dastych |
Immunogenetics | 2013 |
HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination
T Bhandari, J Olson, RS Johnson, V Nizet |
Journal of Molecular Medicine | 2013 |
Cellular Metabolic Regulators: Novel Indicators of Low-Grade Inflammation in Humans
B Haimovich, Z Zhang, JE Calvano, SE Calvano, A Kumar, MA Macor, S Corbett, SM Coyle, SF Lowry |
Annals of Surgery | 2013 |
HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis
EA Berger, SA McClellan, KS Vistisen, LD Hazlett |
PLoS pathogens | 2013 |
Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions
SK Schmidt, S Ebel, E Keil, C Woite, JF Ernst, AE Benzin, J Rupp, W Däubener |
PloS one | 2013 |
Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism
PM Elks, S Brizee, M der Vaart, SR Walmsley, FJ van Eeden, SA Renshaw, AH Meijer |
PLoS pathogens | 2013 |
Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment
E Leire, J Olson, H Isaacs, V Nizet, A Hollands |
Journal of Inflammation | 2013 |
Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure
L Samelko, MS Caicedo, SJ Lim, C Della-Valle, J Jacobs, NJ Hallab |
PloS one | 2013 |
The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
PM Gallo, S Gallucci |
Frontiers in immunology | 2013 |
The expanding world of extracellular traps: not only neutrophils but much more
O Goldmann, E Medina |
Frontiers in immunology | 2013 |
Hypoxia-Inducible Factor 1-Regulated Lysyl Oxidase Is Involved in Staphylococcus aureus Abscess Formation
C Beerlage, J Greb, D Kretschmer, M Assaggaf, PC Trackman, ML Hansmann, M Bonin, JA Eble, A Peschel, B Brüne, VA Kempf, JL Flynn |
Infection and immunity | 2013 |
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis
J Kiss, M Mollenhauer, SR Walmsley, J Kirchberg, P Radhakrishnan, T Niemietz, J Dudda, G Steinert, MK Whyte, P Carmeliet, M Mazzone, J Weitz, M Schneider |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
Pseudomonas aeruginosa Alkyl Quinolones Repress Hypoxia-Inducible Factor 1 (HIF-1) Signaling through HIF-1α Degradation
C Legendre, FJ Reen, MJ Mooij, GP McGlacken, C Adams, F O'Gara, BA McCormick |
Infection and immunity | 2012 |
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process
D Ortiz-Masià, I Díez, S Calatayud, C Hernández, J Cosín-Roger, J Hinojosa, JV Esplugues, MD Barrachina |
PloS one | 2012 |
Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury
H Kobayashi, V Gilbert, Q Liu, PP Kapitsinou, TL Unger, J Rha, S Rivella, D Schlöndorff, VH Haase |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
The pleiotropic effects of erythropoietin in infection and inflammation
M Nairz, T Sonnweber, A Schroll, I Theurl, G Weiss |
Microbes and infection / Institut Pasteur | 2012 |
Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis
S Konisti, S Kiriakidis, EM Paleolog |
Nature Reviews Rheumatology | 2012 |
The updated biology of hypoxia-inducible factor
SN Greer, JL Metcalf, Y Wang, M Ohh |
The EMBO Journal | 2012 |
EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways
LG Luhachack, O Visvikis, AC Wollenberg, A Lacy-Hulbert, LM Stuart, JE Irazoqui |
PLoS pathogens | 2012 |
Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury
Y Wang, Y Liu, A Sidhu, Z Ma, C McClain, W Feng |
American journal of physiology. Gastrointestinal and liver physiology | 2012 |
Hypoxia and fungal pathogenesis: to air or not to air?
N Grahl, KM Shepardson, D Chung, RA Cramer |
Eukaryotic cell | 2012 |
Hypoxia-Mediated Impairment of the Mitochondrial Respiratory Chain Inhibits the Bactericidal Activity of Macrophages
M Wiese, RG Gerlach, I Popp, J Matuszak, M Mahapatro, K Castiglione, D Chakravortty, C Willam, M Hensel, C Bogdan, J Jantsch, BA McCormick |
Infection and immunity | 2012 |
Molecular oxygen sensing: implications for visceral surgery
J Kiss, J Kirchberg, M Schneider |
Langenbeck's Archives of Surgery | 2012 |
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
CY Okumura, A Hollands, DN Tran, J Olson, S Dahesh, M Köckritz-Blickwede, W Thienphrapa, C Corle, SN Jeung, A Kotsakis, RA Shalwitz, RS Johnson, V Nizet |
Journal of Molecular Medicine | 2012 |
Kruppel-Like Factors and Vascular Inflammation: Implications for Atherosclerosis
MA Alaiti, G Orasanu, D Tugal, Y Lu, MK Jain |
Current Atherosclerosis Reports | 2012 |
Intracellular Pathogen Leishmania donovani Activates Hypoxia Inducible Factor-1 by Dual Mechanism for Survival Advantage within Macrophage
AK Singh, C Mukhopadhyay, S Biswas, VK Singh, CK Mukhopadhyay |
PloS one | 2012 |
Systemic VHL gene functions and the VHL disease
HL Bader, T Hsu |
FEBS Letters | 2012 |
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps
K Branitzki‑Heinemann, CY Okumura, L Völlger, Y Kawakami, T Kawakami, HY Naim, V Nizet, MV Köckritz‑Blickwede |
Biochemical Journal | 2012 |
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
LE Alexander, K Akong-Moore, S Feldstein, P Johansson, A Nguyen, EK McEachern, S Nicatia, AS Cowburn, J Olson, JY Cho, H Isaacs, RS Johnson, DH Broide, V Nizet |
Journal of Molecular Medicine | 2012 |
New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation
M Pelletier, TS Lepow, LK Billingham, MP Murphy, RM Siegel |
Seminars in Immunology | 2012 |
Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1
AM McInturff, MJ Cody, EA Elliott, JW Glenn, JW Rowley, MT Rondina, CC Yost |
Blood | 2012 |
Fueling the flame: bioenergy couples metabolism and inflammation
TF Liu, CM Brown, ME Gazzar, L McPhail, P Millet, A Rao, VT Vachharajani, BK Yoza, CE McCall |
Journal of leukocyte biology | 2012 |
Anti-inflammatory properties of histone deacetylase inhibitors: A mechanistic study
W Chong, Y Li, B Liu, Z Liu, T Zhao, DR Wonsey, C Chen, GC Velmahos, MA deMoya, DR King, AL Kung, HB Alam |
The Journal of trauma | 2012 |
Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP
KC Liao, J Mogridge, SR Blanke |
Infection and immunity | 2012 |
Von Hippel-Lindau Disease (VHL): A need for a murine model with retinal hemangioblastoma
Park S, Chan CC |
Histology and histopathology | 2012 |
Prolyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Sarah Walmsley, Edwin Chilvers, Alfred Thompson, Kathryn Vaughan, Helen Marriott, Lisa Parker, Gary Shaw, Selina Parmar, Martin Schneider, Ian Sabroe, David Dockrell, Marta Milo, Cormac Taylor, Randall Johnson, Christopher Pugh, Peter Ratcliffe, Patrick H. Maxwell, Peter Carmeliet, Moira Whyte |
Journal of Clinical Investigation | 2011 |
Regulation of Hypoxia-Inducible Factor-1α and Erythropoiesis by Herpesvirus Entry Mediator in Mice
Sakoda Yukimi, Sudarshan Anand, Yuming Zhao, JangJune Park, Yingjia Liu, Atsuo Kuramasu, Nico van Rooijen, Ling Chen, Scott Strome, Wayne W. Hancock, Lieping Chen, Koji Tamada |
Journal of Clinical Investigation | 2011 |
Cholinergic Regulation of Keratinocyte Innate Immunity and Permeability Barrier Integrity: New Perspectives in Epidermal Immunity and Disease
BJ Curtis, KA Radek |
Journal of Investigative Dermatology | 2011 |
Interactions between Nitric Oxide and Hypoxia-Inducible Factor Signaling Pathways in Inflammatory Disease
N Olson, A der Vliet |
Nitric Oxide | 2011 |
Hypoxia and Metabolic Factors that Influence IBD Pathogenesis
LE Glover, SP Colgan |
Gastroenterology | 2011 |
Hypoxia and Inflammation
HK Eltzschig, P Carmeliet |
New England Journal of Medicine | 2011 |
Macrophages, Meta-Inflammation, and Immuno-Metabolism
H Shapiro, A Lutaty, A Ariel |
TheScientificWorldJournal | 2011 |
Implications of hypoxic microenvironments during invasive aspergillosis
SJ Wezensky, RA Cramer |
Medical mycology : official publication of the International Society for Human and Animal Mycology | 2011 |
Hypoxia: a double-edged sword of immunity
A Sica, G Melillo, L Varesio |
Journal of Molecular Medicine | 2011 |
The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
GH Mahabeleshwar, D Kawanami, N Sharma, Y Takami, G Zhou, H Shi, L Nayak, D Jeyaraj, R Grealy, M White, R McManus, T Ryan, P Leahy, Z Lin, SM Haldar, GB Atkins, HR Wong, JB Lingrel, MK Jain |
Immunity | 2011 |
Targeting the host–pathogen interface for treatment of Staphylococcus aureus infection
B Park, GY Liu |
Seminars in Immunopathology | 2011 |
A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis
TW van Hal, L Bon, TR Radstake |
International Journal of Rheumatology | 2011 |
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis
GH Mahabeleshwar, MA Qureshi, Y Takami, N Sharma, JB Lingrel, MK Jain |
The Journal of biological chemistry | 2011 |
Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections
AS Zinkernagel, P Hruz, S Uchiyama, M Köckritz-Blickwede, RA Schuepbach, T Hayashi, DA Carson, V Nizet |
Journal of Innate Immunity | 2011 |
Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats
D Popa, Z Fu, A Go, FL Powell |
Respiratory Physiology & Neurobiology | 2011 |
The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity
EM Sparkenbaugh, Y Saini, KK Greenwood, JJ LaPres, JP Luyendyk, BL Copple, JF Maddox, PE Ganey, RA Roth |
The Journal of pharmacology and experimental therapeutics | 2011 |
Hypoxia-inducible factor-2alpha regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Imtiyaz, Emily Williams, Michele Hickey, Shetal Patel, Amy Durham, Li J Yuan, Rachel Hammond, Phyllis Gimotty, Brian Keith, M. Celeste Simon |
Journal of Clinical Investigation | 2010 |
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens
N Werth, C Beerlage, C Rosenberger, AS Yazdi, M Edelmann, A Amr, W Bernhardt, C Eiff, K Becker, A Schäfer, A Peschel, VA Kempf |
PloS one | 2010 |
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
N Takeda, EL O'Dea, A Doedens, J Kim, A Weidemann, C Stockmann, M Asagiri, MC Simon, A Hoffmann, RS Johnson |
Genes & development | 2010 |
Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation
I Díez, S Calatayud, C Hernández, E Quintana, JE O'Connor, JV Esplugues, MD Barrachina |
British Journal of Pharmacology | 2010 |
Iron Homeostasis and the Inflammatory Response
M Wessling-Resnick |
Annual Review of Nutrition | 2010 |
Diverse Effects of Hypoxia on Tumor Progression
MC Simon |
2010 | |
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
AL Doedens, C Stockmann, MP Rubinstein, D Liao, N Zhang, DG DeNardo, LM Coussens, M Karin, AW Goldrath, RS Johnson |
Cancer research | 2010 |
Iron and the immune system
RJ Ward, RR Crichton, DL Taylor, LD Corte, SK Srai, DT Dexter |
Journal of Neural Transmission | 2010 |
Modulation of NF-κB and Hypoxia-Inducible Factor−1 by S-Nitrosoglutathione Does Not Alter Allergic Airway Inflammation in Mice
N Olson, DI Kasahara, M Hristova, R Bernstein, Y Janssen-Heininger, A der Vliet |
American journal of respiratory cell and molecular biology | 2010 |
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions
R Spirig, S Djafarzadeh, T Regueira, SG Shaw, C Garnier, J Takala, SM Jakob, R Rieben, PM Lepper |
PloS one | 2010 |
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
AJ Majmundar, WJ Wong, MC Simon |
Molecular Cell | 2010 |
Reactive Oxygen Species Enhance TLR10 Expression in the Human Monocytic Cell Line THP-1
D Kim, YJ Kim, HS Koh, TY Jang, HE Park, JY Kim |
International journal of molecular sciences | 2010 |
Microglia in ischemic brain injury
JR Weinstein, IP Koerner, T Möller |
Future Neurology | 2010 |
Toxoplasma gondii Activates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling*
M Wiley, KR Sweeney, DA Chan, KM Brown, C McMurtrey, EW Howard, AJ Giaccia, IJ Blader |
The Journal of biological chemistry | 2010 |
Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils
NN McGovern, AS Cowburn, L Porter, SR Walmsley, C Summers, AA Thompson, S Anwar, LC Willcocks, MK Whyte, AM Condliffe, ER Chilvers |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage: Ischemic Stroke and HIF-1α Induces Nix and VEGF
SH Yeh, LC Ou, PW Gean, JJ Hung, WC Chang |
Brain Pathology | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Adenosine: An Old Drug Newly Discovered
HK Eltzschig |
Anesthesiology | 2009 |
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
P Fraisl, J Aragonés, P Carmeliet |
Nature Reviews Drug Discovery | 2009 |
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
P Rosenberger, JM Schwab, V Mirakaj, E Masekowsky, A Mager, JC Morote-Garcia, K Unertl, HK Eltzschig |
Nature Immunology | 2009 |
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
HK Eltzschig, J Rivera-Nieves, SP Colgan |
Expert Opinion on Therapeutic Targets | 2009 |
Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections
A Nijnik, R Hancock |
Emerging Health Threats Journal | 2009 |
Interdependence of hypoxic and innate immune responses
V Nizet, RS Johnson |
Nature Reviews Immunology | 2009 |
Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation
CH Hsieh, EA Nickel, JT Hsu, MG Schwacha, KI Bland, IH Chaudry |
Annals of Surgery | 2009 |
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans
A Bellier, CS Chen, CY Kao, HN Cinar, RV Aroian |
PLoS pathogens | 2009 |
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
WM Bernhardt, U Gottmann, F Doyon, B Buchholz, V Campean, J Schödel, A Reisenbuechler, S Klaus, M Arend, L Flippin, C Willam, MS Wiesener, B Yard, C Warnecke, KU Eckardt |
Proceedings of the National Academy of Sciences | 2009 |
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
HY Fang, R Hughes, C Murdoch, SB Coffelt, SK Biswas, AL Harris, RS Johnson, HZ Imityaz, MC Simon, E Fredlund, FR Greten, J Rius, CE Lewis |
Blood | 2009 |
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
SR Walmsley, ER Chilvers, MK Whyte |
Arthritis Research & Therapy | 2009 |
Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1
K Shirato, T Kizaki, T Sakurai, J Ogasawara, Y Ishibashi, T Iijima, C Okada, I Noguchi, K Imaizumi, N Taniguchi, H Ohno |
Pflügers Archiv - European Journal of Physiology | 2009 |
The multiple actions of NO
Y Gao |
Pflügers Archiv - European Journal of Physiology | 2009 |
Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity
L Wang, BJ Cherayil |
Journal of Innate Immunity | 2009 |
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling
M Scortegagna, C Cataisson, RJ Martin, DJ Hicklin, RD Schreiber, SH Yuspa, JM Arbeit |
Blood | 2008 |
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
HA Haeberle, C Dürrstein, P Rosenberger, YM Hosakote, J Kuhlicke, VA Kempf, RP Garofalo, HK Eltzschig |
PloS one | 2008 |
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells
Z Li, Z Lai, K Ya, D Fang, YW Ho, Y Lei, QZ Ming |
Journal of Cellular and Molecular Medicine | 2008 |
Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection
MM Peterson, JL Mack, PR Hall, AA Alsup, SM Alexander, EK Sully, YS Sawires, AL Cheung, M Otto, HD Gresham |
Cell Host & Microbe | 2008 |
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
J Rius, M Guma, C Schachtrup, K Akassoglou, AS Zinkernagel, V Nizet, RS Johnson, GG Haddad, M Karin |
Nature | 2008 |
Acute inactivation of the VHL gene contributes to protective effects of ischemic preconditioning in the mouse kidney
M Iguchi, Y Kakinuma, A Kurabayashi, T Sato, T Shuin, SB Hong, LS Schmidt, M Furihata |
Nephron. Experimental nephrology | 2008 |
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body
FL Powell |
American journal of physiology. Lung cellular and molecular physiology | 2008 |
IKKbeta/NF-kappaB and the miscreant macrophage
AM Timmer, V Nizet |
Journal of Experimental Medicine | 2008 |
Complex regulation of human cathelicidin gene expression: novel splice variants and 5'UTR negative regulatory element
HZ Elloumi, SM Holland |
Molecular Immunology | 2008 |
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
J Kuhlicke, JS Frick, JC Morote-Garcia, P Rosenberger, HK Eltzschig |
PloS one | 2007 |
Regulation of HIF-1alpha stability through S-nitrosylation
F Li, P Sonveaux, ZN Rabbani, S Liu, B Yan, Q Huang, Z Vujaskovic, MW Dewhirst, CY Li |
Molecular Cell | 2007 |
Hypoxia inducible factor (HIF) function in innate immunity and infection
AS Zinkernagel, RS Johnson, V Nizet |
Journal of Molecular Medicine | 2007 |
Genetic Characterization and Virulence Role of the RALP3/LSA Locus Upstream of the Streptolysin S Operon in Invasive M1T1 Group A Streptococcus
LA Kwinn, A Khosravi, RK Aziz, AM Timmer, KS Doran, M Kotb, V Nizet |
Journal of bacteriology | 2007 |
Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
HK Eltzschig, M Faigle, S Knapp, J Karhausen, J Ibla, P Rosenberger, KC Odegard, PC Laussen, LF Thompson, SP Colgan |
Blood | 2006 |
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection
P Mydel, Y Takahashi, H Yumoto, M Sztukowska, M Kubica, FC 3rd, DM Kurtz, J Travis, LV Collins, KA Nguyen, CA Genco, J Potempa |
PLoS pathogens | 2006 |
Tumor macrophage redox and effector mechanisms associated with hypoxia
MG Espey |
Free radical biology & medicine | 2006 |
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
C Peyssonnaux, AS Zinkernagel, V Datta, X Lauth, RS Johnson, V Nizet |
Blood | 2006 |
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, RA Wagner, DR Greaves, PJ Murray, A Chawla |
Cell Metabolism | 2006 |
Hypoxic adaptation during development: relation to pattern of neurological presentation and cognitive disability
FJ Kirkham, AK Datta |
Developmental science | 2006 |
Loss of VHL Confers Hypoxia-Inducible Factor (HIF)-Dependent Resistance to Vesicular Stomatitis Virus: Role of HIF in Antiviral Response
II Hwang, IR Watson, SD Der, M Ohh |
Journal of virology | 2006 |
HIF-1α: a master regulator of innate host defenses?
KA Zarember, HL Malech |
Journal of Clinical Investigation | 2005 |
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction
AK Neumann, J Yang, MP Biju, SK Joseph, RS Johnson, VH Haase, BD Freedman, LA Turka |
Proceedings of the National Academy of Sciences | 2005 |