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Citations to this article

HIF-1α expression regulates the bactericidal capacity of phagocytes
Carole Peyssonnaux, … , Victor Nizet, Randall S. Johnson
Carole Peyssonnaux, … , Victor Nizet, Randall S. Johnson
Published July 1, 2005
Citation Information: J Clin Invest. 2005;115(7):1806-1815. https://doi.org/10.1172/JCI23865.
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Research Article Infectious disease Article has an altmetric score of 9

HIF-1α expression regulates the bactericidal capacity of phagocytes

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Abstract

Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, α subunit (HIF-1α) to myeloid cell innate immune function. HIF-1α was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-α. Mice lacking HIF-1α in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus. Conversely, activation of the HIF-1α pathway through deletion of von Hippel–Lindau tumor-suppressor protein or pharmacologic inducers supported myeloid cell production of defense factors and improved bactericidal capacity. HIF-1α control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense.

Authors

Carole Peyssonnaux, Vivekanand Datta, Thorsten Cramer, Andrew Doedens, Emmanuel A. Theodorakis, Richard L. Gallo, Nancy Hurtado-Ziola, Victor Nizet, Randall S. Johnson

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PloS one 2020
Hypoxia and Innate Immunity: Keeping Up with the HIFsters
SP Colgan, GT Furuta, CT Taylor
Annual Review of Immunology 2020
Hypoxia and HIF Signaling: One Axis with Divergent Effects
C Corrado, S Fontana
International journal of molecular sciences 2020
Whole blood transcriptional responses of very preterm infants during late-onset sepsis
S Ng, T Strunk, AH Lee, EE Gill, R Falsafi, T Woodman, J Hibbert, RE Hancock, A Currie, FJ Esteban
PloS one 2020
Carbohydrate and Amino Acid Metabolism as Hallmarks for Innate Immune Cell Activation and Function
H Zhao, LN Raines, SC Huang
Cells 2020
Mechanisms controlling bacterial infection in myeloid cells under hypoxic conditions
I Hayek, V Schatz, C Bogdan, J Jantsch, A Lührmann
Cellular and Molecular Life Sciences 2020
Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization
P Díaz-Bulnes, ML Saiz, C López-Larrea, RM Rodríguez
Frontiers in immunology 2020
The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
KM Lodge, AS Cowburn, W Li, AM Condliffe
International journal of molecular sciences 2020
Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
MF Coleman, AJ Cozzo, AJ Pfeil, SK Etigunta, SD Hursting
Cancers 2020
Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier
F Puértolas-Balint, BO Schroeder
Frontiers in immunology 2020
Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells
C Zhao, J Chen, L Cheng, K Xu, Y Yang, X Su
Emerging Microbes & Infections 2020
Short-Chain Fatty Acids Promote Intracellular Bactericidal Activity in Head Kidney Macrophages From Turbot (Scophthalmus maximus L.) via Hypoxia Inducible Factor-1α
J Zhang, H Zhang, M Liu, Y Lan, H Sun, K Mai, M Wan
Frontiers in immunology 2020
Antimicrobial Resistance in ESKAPE Pathogens
DM Oliveira, BM Forde, TJ Kidd, PN Harris, MA Schembri, SA Beatson, DL Paterson, MJ Walker
Clinical microbiology reviews 2020
Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine
K Hirota
Biomedicines 2020
Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound
M Baiula, R Greco, L Ferrazzano, A Caligiana, K Hoxha, D Bandini, P Longobardi, S Spampinato, A Tolomelli, N Aykin-Burns
PloS one 2020
Replication of Salmonella enterica serovar Typhimurium in RAW264.7 Phagocytes Correlates With Hypoxia and Lack of iNOS Expression
M Wrande, K Vestö, SP Banesaru, N Anwar, J Nordfjell, L Liu, GM McInerney, M Rhen
Frontiers in Cellular and Infection Microbiology 2020
Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of “same treatment for different diseases” in traditional Chinese medicine
He RP, Jin Z, Ma RY, Hu FD, Dai JY
Chinese Herbal Medicines 2020
Epidermal hepcidin is required for neutrophil response to bacterial infection
Mariangela Malerba, Sabine Louis, Sylvain Cuvellier, Srikanth Mairpady Shambat, Camille Hua, Camille Gomart, Agnès Fouet, Nicolas Ortonne, Jean-Winoc Decousser, Annelies Sophie Zinkernagel, Jacques RR Mathieu, Carole Peyssonnaux
Journal of Clinical Investigation 2019
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell, Adrian Erlebacher
Journal of Clinical Investigation 2019
Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?
A Remot, E Doz, N Winter
Frontiers in immunology 2019
Immunometabolism and Sepsis: A Role for HIF?
SF Fitzpatrick
Frontiers in Molecular Biosciences 2019
Immunometabolic cross-talk in the inflamed heart
FM Marelli-Berg, D Aksentijevic
2019
Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis
C Scott, R Stokes, KM Cha, A Clouston, M Eslam, M Metwally, MM Swarbrick, J George, JE Gunton, MB Aguila
PloS one 2019
The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity
R Golonka, BS Yeoh, M Vijay-Kumar
Journal of Innate Immunity 2019
Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia
DS Dzhalilova, AM Kosyreva, ME Diatroptov, NA Zolotova, IS Tsvetkov, VA Mkhitarov, OV Makarova, DN Khochanskiy
International Journal of Inflammation 2019
Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization
JY Tinevez, ET Arena, M Anderson, G Nigro, L Injarabian, A André, M Ferrari, FX Campbell-Valois, A Devin, SL Shorte, PJ Sansonetti, BS Marteyn
Nature Microbiology 2019
Reassessing the Host Defense Peptide Landscape
EF Haney, SK Straus, RE Hancock
Frontiers in Chemistry 2019
The Activin Receptor, Activin-Like Kinase 4, Mediates Toxoplasma Gondii Activation of Hypoxia Inducible Factor-1
A Lis, M Wiley, J Vaughan, PC Gray, IJ Blader
Frontiers in Cellular and Infection Microbiology 2019
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
SK Daniel, KM Sullivan, KP Labadie, VG Pillarisetty
Clinical and Translational Medicine 2019
Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response
P Sadiku, SR Walmsley
EMBO reports 2019
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells
TP Chapman, D Corridoni, S Shiraishi, S Pandey, A Aulicino, S Wigfield, M do Carmo Costa, ML Thézénas, H Paulson, R Fischer, BM Kessler, A Simmons
Frontiers in immunology 2019
The HIF-1α/LC3-II Axis Impacts Fungal Immunity in Human Macrophages
D Friedrich, D Zapf, B Lohse, RA Fecher, GS Deepe, J Rupp, L Pirofski
Infection and immunity 2019
Does Neutrophil Phenotype Predict the Survival of Trauma Patients?
E Mortaz, SS Zadian, M Shahir, G Folkerts, J Garssen, S Mumby, IM Adcock
Frontiers in immunology 2019
Hypoxic Regulation of Neutrophils in Cancer
D Triner, YM Shah
International journal of molecular sciences 2019
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
Z Jian, R Liu, X Zhu, D Smerin, Y Zhong, L Gu, W Fang, X Xiong
Frontiers in immunology 2019
Metabolic Insight of Neutrophils in Health and Disease
S Kumar, M Dikshit
Frontiers in immunology 2019
Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo
A Lewis, PM Elks
Frontiers in immunology 2019
Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection
M Osada-Oka, N Goda, H Saiga, M Yamamoto, K Takeda, Y Ozeki, T Yamaguchi, T Soga, Y Tateishi, K Miura, D Okuzaki, K Kobayashi, S Matsumoto
International Immunology 2019
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus
NH Hajdamowicz, RC Hull, SJ Foster, AM Condliffe
International journal of molecular sciences 2019
Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo
Q Deng, J Wei, P Zou, Y Xiao, Z Zeng, Y Shi, Y Zhan, H Zhang, B Tang, Q Zeng, R Xiao
Oxidative medicine and cellular longevity 2019
HIF-1α as a central mediator of cellular resistance to intracellular pathogens
M Knight, S Stanley
Current Opinion in Immunology 2019
Coupling Krebs cycle metabolites to signalling in immunity and cancer
DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA ONeill, EL Mills
2018
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis
J Goodwin, H Choi, M Hsieh, ML Neugent, JM Ahn, HN Hayenga, PK Singh, DB Shackelford, IK Lee, V Shulaev, S Dhar, N Takeda, J Kim
American journal of respiratory cell and molecular biology 2018
Hypoxia Signaling in Vascular Homeostasis
G Marsboom, J Rehman
Physiology (Bethesda, Md.) 2018
Leishmania donovani Activates Hypoxia Inducible Factor-1α and miR-210 for Survival in Macrophages by Downregulation of NF-κB Mediated Pro-inflammatory Immune Response
V Kumar, A Kumar, S Das, A Kumar, K Abhishek, S Verma, A Mandal, RK Singh, P Das
Frontiers in microbiology 2018
Resveratrol Acts Anti-Inflammatory and Neuroprotective in an Infant Rat Model of Pneumococcal Meningitis by Modulating the Hippocampal miRNome
KB de Queiroz, T dos Santos Fontes Pereira, MS Araújo, RS Gomez, RS Coimbra
Molecular Neurobiology 2018
Effect of Hypoxia on the Pathogenesis of Acinetobacter baumannii and Pseudomonas aeruginosa In Vitro and in Murine Experimental Models of Infection
ML Gil-Marqués, ME Pachón-Ibáñez, J Pachón, Y Smani, M Whiteley
Infection and immunity 2018
Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta
SL Maas, O Soehnlein, JR Viola
Frontiers in immunology 2018
Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium
S Simmen, J Cosin-Roger, H Melhem, N Maliachovas, M Maane, K Baebler, B Weder, C Maeyashiki, K Spanaus, M Scharl, C de Vallière, J Zeitz, SR Vavricka, M Hausmann, G Rogler, PA Ruiz
CMGH Cellular and Molecular Gastroenterology and Hepatology 2018
Hypoxia and hyperbaric oxygen therapy: a review
R Choudhury
International journal of general medicine 2018
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
X Meng, B Grötsch, Y Luo, KX Knaup, MS Wiesener, XX Chen, J Jantsch, S Fillatreau, G Schett, A Bozec
Nature Communications 2018
Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway
R Guan, J Wang, Z Li, M Ding, D Li, G Xu, T Wang, Y Chen, Q Yang, Z Long, Z Cai, C Zhang, X Liang, L Dong, L Zhao, H Zhang, D Sun, W Lu
Frontiers in pharmacology 2018
Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss
K Hirai, H Furusho, K Hirota, H Sasaki
International Journal of Oral Science 2018
The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer
ST McSorley, CS Roxburgh, PG Horgan, DC McMillan
Perioperative Medicine 2018
Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses
D Ahmed, A Jaworski, D Roy, W Willmore, A Golshani, E Cassol
Mediators of Inflammation 2018
Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges
CY Chiang, I Uzoma, RT Moore, M Gilbert, AJ Duplantier, RG Panchal, R Rappuoli, DA Garsin
mBio 2018
Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
V Schatz, P Neubert, F Rieger, J Jantsch
Frontiers in immunology 2018
Hypoxia and acidosis: immune suppressors and therapeutic targets
S Damgaci, A Ibrahim-Hashim, PM Enriquez-Navas, S Pilon-Thomas, A Guvenis, RJ Gillies
Immunology 2018
Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells
C Domblides, L Lartigue, B Faustin
Cells 2018
Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function
HM Izquierdo, P Brandi, MJ Gómez, R Conde-Garrosa, E Priego, M Enamorado, S Martínez-Cano, I Sánchez, L Conejero, D Jimenez-Carretero, S Martín-Puig, M Guilliams, D Sancho
Cell Reports 2018
Choline transport links macrophage phospholipid metabolism and inflammation
SA Snider, KD Margison, P Ghorbani, ND LeBlond, C O'Dwyer, JR Nunes, T Nguyen, H Xu, SA Bennett, MD Fullerton
The Journal of biological chemistry 2018
Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
M Knight, J Braverman, K Asfaha, K Gronert, S Stanley, P Salgame
PLoS pathogens 2018
Hypoxia, Metabolism and Immune Cell Function
E Krzywinska, C Stockmann
Biomedicines 2018
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues
JL Ebersole, MJ Novak, L Orraca, J Martinez-Gonzalez, S Kirakodu, KC Chen, A Stromberg, OA Gonzalez
Immunology 2018
HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection
C Li, Y Wang, Y Li, Q Yu, , X Wang, A Jia, Y Hu, L Han, J Wang, H Yang, D Yan, Y Bi, G Liu
Scientific Reports 2018
Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis
CW Ong, K Fox, A Ettorre, PT Elkington, JS Friedland
Scientific Reports 2018
HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis
A Hammami, BM Abidin, KM Heinonen, S Stäger
Scientific Reports 2018
Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia
N Gupta, V Nizet
Frontiers in Medicine 2018
Gastric Aspiration and Its Role in Airway Inflammation
EB Hunt, A Sullivan, J Galvin, J MacSharry, DM Murphy
The open respiratory medicine journal 2018
Vitamin C and immune cell function in inflammation and cancer
A Ang, JM Pullar, MJ Currie, MC Vissers
Biochemical Society Transactions 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation
W Zhang, Q Li, D Li, J Li, D Aki, YC Liu
Journal of Experimental Medicine 2018
Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection
T Escajadillo, V Nizet
Toxins 2018
Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting
V Kumar
Inflammation 2018
Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
MJ Rey, Á Valín, A Usategui, CM García-Herrero, M Sánchez-Aragó, JM Cuezva, M Galindo, B Bravo, JD Cañete, FJ Blanco, G Criado, JL Pablos
Scientific Reports 2017
Energy metabolic pathways control the fate and function of myeloid immune cells
AA Al-Khami, PC Rodriguez, AC Ochoa
Journal of leukocyte biology 2017
Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo
RS Dickinson, F Murphy, C Doherty, S Williams, A Mirchandani, J Willson, JS Scotti, G Preston, CJ Schofield, MK Whyte, SR Walmsley
Wellcome Open Research 2017
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
J Cosin-Roger, S Simmen, H Melhem, K Atrott, I Frey-Wagner, M Hausmann, C Vallière, MR Spalinger, P Spielmann, RH Wenger, J Zeitz, SR Vavricka, G Rogler, PA Ruiz
Nature Communications 2017
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
SV Welden, AC Selfridge, P Hindryckx
Nature Reviews Gastroenterology & Hepatology 2017
Oxygen metabolism and innate immune responses in the gut
SP Colgan, EL Campbell
Journal of applied physiology 2017
Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil
SM Lawrence, R Corriden, V Nizet
Frontiers in Pediatrics 2017
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
G Prosser, J Brandenburg, N Reiling, CE Barry, RJ Wilkinson, KA Wilkinson
Microbes and Infection 2017
CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
S Labiano, F Meléndez-Rodríguez, A Palazón, Á Teijeira, S Garasa, I Etxeberria, MÁ Aznar, AR Sánchez-Paulete, A Azpilikueta, E Bolaños, C Molina, H la Fuente, P Maiso, F Sánchez-Madrid, MO de Landázuri, J Aragonés, I Melero
OncoImmunology 2017
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
AA Thompson, RS Dickinson, F Murphy, JP Thomson, HM Marriott, A Tavares, J Willson, L Williams, A Lewis, A Mirchandani, PD Coelho, C Doherty, E Ryan, E Watts, NM Morton, S Forbes, RH Stimson, AG Hameed, N Arnold, JA Preston, A Lawrie, V Finisguerra, M Mazzone, P Sadiku, J Goveia, F Taverna, P Carmeliet, SJ Foster, ER Chilvers, AS Cowburn, DH Dockrell, RS Johnson, RR Meehan, MK Whyte, SR Walmsley
Science Immunology 2017
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye
PJ Gardner, SE Liyanage, E Cristante, RD Sampson, AD Dick, RR Ali, JW Bainbridge
Scientific Reports 2017
Pharmacological Targeting of the Host–Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs
J Munguia, V Nizet
Trends in Pharmacological Sciences 2017
Role of AHR and HIF-1α in Glioblastoma Metabolism
G Gabriely, MA Wheeler, MC Takenaka, FJ Quintana
Trends in Endocrinology & Metabolism 2017
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis
DW Park, JW Zmijewski
Infection & Chemotherapy 2017
Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection
H Möllerherm, K Branitzki-Heinemann, G Brogden, AA Elamin, W Oehlmann, H Fuhrmann, M Singh, HY Naim, M Köckritz-Blickwede
Frontiers in immunology 2017
Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
C Gerri, R Marín-Juez, M Marass, A Marks, HM Maischein, DY Stainier
Nature Communications 2017
Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages
F Guan, XJ Lu, CH Li, J Chen, SG Lee
PloS one 2017
HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis
A Hammami, BM Abidin, T Charpentier, A Fabié, AP Duguay, KM Heinonen, S Stäger, D Sacks
PLoS pathogens 2017
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization
A Vettori, D Greenald, GK Wilson, M Peron, N Facchinello, E Markham, M Sinnakaruppan, LC Matthews, JA McKeating, F Argenton, FJ van Eeden
Proceedings of the National Academy of Sciences 2017
Pharmacological HIF-inhibition attenuates postoperative adhesion formation
MJ Strowitzki, AS Ritter, P Radhakrishnan, JM Harnoss, VM Opitz, M Biller, J Wehrmann, U Keppler, J Scheer, M Wallwiener, T Schmidt, A Ulrich, M Schneider
Scientific Reports 2017
Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB
J Braverman, SA Stanley
Journal of immunology (Baltimore, Md. : 1950) 2017
Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus
YL Cheng, YW Wu, CF Kuo, SL Lu, FT Liu, R Anderson, CF Lin, YL Liu, WY Wang, YD Chen, PX Zheng, JJ Wu, YS Lin, JT Patton
mBio 2017
Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions
H Möllerherm, K Meier, K Schmies, H Fuhrmann, HY Naim, M Köckritz-Blickwede, K Branitzki-Heinemann
Frontiers in immunology 2017
Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection
T Schreiber, T Quinting, U Dittmer, J Fandrey, K Sutter
Scientific Reports 2017
HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
SA Santos, DR de Júnior
Revista do Instituto de Medicina Tropical de São Paulo 2017
CITED2 Restrains Proinflammatory Macrophage Activation and Response
GD Kim, R Das, X Rao, J Zhong, JA Deiuliis, DL Ramirez-Bergeron, S Rajagopalan, GH Mahabeleshwar
Molecular and cellular biology 2017
Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity
D Friedrich, RA Fecher, J Rupp, GS Deepe
Microbes and infection / Institut Pasteur 2017
METABOLIC INFLAMMATORY COMPLEX IN SEPSIS: SEPTIC CACHEXIA AS A NOVEL POTENTIAL THERAPEUTIC TARGET
Kaneki M
Shock (Augusta, Ga.) 2017
Hypoxia-dependent regulation of inflammatory pathways in immune cells
Cormac Taylor, Glen Doherty, Padraic Fallon, Eoin Cummins
Journal of Clinical Investigation 2016
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Nan Lin, M. Celeste Simon
Journal of Clinical Investigation 2016
Neutrophils and the inflammatory tissue microenvironment in the mucosa
EL Campbell, DJ Kao, SP Colgan
Immunological Reviews 2016
Immunologic Consequences of Hypoxia during Critical Illness:
HD Kiers, GJ Scheffer, JG van der Hoeven, HK Eltzschig, P Pickkers, M Kox
Anesthesiology 2016
Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils
L Vollger, K Akong-Moore, L Cox, O Goldmann, Y Wang, ST Schafer, HY Naim, V Nizet, M Kockritz-Blickwede
Bioscience Reports 2016
Metabolic Factors that Contribute to Lupus Pathogenesis
W Li, R Sivakumar, AA Titov, SC Choi, L Morel
Critical reviews in immunology 2016
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases
A Egners, M Erdem, T Cramer
Mediators of Inflammation 2016
Inverse Correlation between IL-10 and HIF-1  in Macrophages Infected with Histoplasma capsulatum
RA Fecher, MC Horwath, D Friedrich, J Rupp, GS Deepe
Journal of immunology (Baltimore, Md. : 1950) 2016
Macrophages and Iron Metabolism
MP Soares, I Hamza
Immunity 2016
Hypoxia and tissue destruction in pulmonary TB
M Belton, S Brilha, R Manavaki, F Mauri, K Nijran, YT Hong, NH Patel, M Dembek, L Tezera, J Green, R Moores, F Aigbirhio, A Al-Nahhas, TD Fryer, PT Elkington, JS Friedland
Thorax 2016
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1  expression
R Jones, KE McDonald, JA Willson, B Ghesquiere, D Sammut, E Daniel, AJ Harris, A Lewis, AA Thompson, RS Dickinson, T Plant, F Murphy, P Sadiku, BG Keevil, P Carmeliet, MK Whyte, J Newell-Price, SR Walmsley
Blood 2016
Mincle Signaling Promotes Con A Hepatitis
SH Greco, A Torres-Hernandez, A Kalabin, C Whiteman, R Rokosh, S Ravirala, A Ochi, J Gutierrez, MA Salyana, VR Mani, SV Nagaraj, M Deutsch, L Seifert, D Daley, R Barilla, M Hundeyin, Y Nikifrov, K Tejada, BE Gelb, SC Katz, G Miller
Journal of immunology (Baltimore, Md. : 1950) 2016
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
H Semba, N Takeda, T Isagawa, Y Sugiura, K Honda, M Wake, H Miyazawa, Y Yamaguchi, M Miura, DM Jenkins, H Choi, J Kim, M Asagiri, AS Cowburn, H Abe, K Soma, K Koyama, M Katoh, K Sayama, N Goda, RS Johnson, I Manabe, R Nagai, I Komuro
Nature Communications 2016
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors
E Miraglia, F Nylén, K Johansson, E Arnér, M Cebula, S Farmand, H Ottosson, R Strömberg, GH Gudmundsson, B Agerberth, P Bergman
Scientific Reports 2016
Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps
H Möllerherm, M Köckritz-Blickwede, K Branitzki-Heinemann
Frontiers in immunology 2016
Immunometabolism in Tuberculosis
L Shi, EA Eugenin, S Subbian
Frontiers in immunology 2016
HIF-1  Is an Essential Mediator of IFN- -Dependent Immunity to Mycobacterium tuberculosis
J Braverman, KM Sogi, D Benjamin, DK Nomura, SA Stanley
Journal of immunology (Baltimore, Md. : 1950) 2016
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
L Huynh, A Kusnadi, SH Park, K Murata, KH Park-Min, LB Ivashkiv
Scientific Reports 2016
Hypoxia and its implications in rheumatoid arthritis
CM Quiñonez-Flores, SA González-Chávez, C Pacheco-Tena
Journal of Biomedical Science 2016
The impact of inflammation on respiratory plasticity
AD Hocker, JA Stokes, FL Powell, AG Huxtable
Experimental Neurology 2016
Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1α Stabilization during Pneumonia
VI Holden, P Breen, S Houle, CM Dozois, MA Bachman
mBio 2016
Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans
KE Basaran, M Villongco, B Ho, E Ellis, R Zarndt, J Antonova, SR Hopkins, FL Powell, HK Eltzschig
PloS one 2016
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis
S Dehn, M DeBerge, XY Yeap, L Yvan-Charvet, D Fang, HK Eltzschig, SD Miller, EB Thorp
Journal of immunology (Baltimore, Md. : 1950) 2016
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
BR Wilson, AR Bogdan, M Miyazawa, K Hashimoto, Y Tsuji
Trends in Molecular Medicine 2016
Formation of Neutrophil Extracellular Traps under Low Oxygen Level
K Branitzki-Heinemann, H Möllerherm, L Völlger, DM Husein, N Buhr, S Blodkamp, F Reuner, G Brogden, HY Naim, M Köckritz-Blickwede
Frontiers in immunology 2016
The complexities of bacterial-fungal interactions in the mammalian gastrointestinal tract
E Lopez-Medina, AY Koh
Microbial Cell 2016
Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence
CH Kowalski, SR Beattie, KK Fuller, EA McGurk, YW Tang, TM Hohl, JJ Obar, RA Cramer
mBio 2016
Myeloid Cell–Derived HIF-1α Promotes Control of Leishmania major
V Schatz, Y Strüssmann, A Mahnke, G Schley, M Waldner, U Ritter, J Wild, C Willam, N Dehne, B Brüne, JM McNiff, OR Colegio, C Bogdan, J Jantsch
Journal of immunology (Baltimore, Md. : 1950) 2016
Bacterial Evasion of Host Antimicrobial Peptide Defenses
Cole JN, Nizet V
Microbiology spectrum 2016
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
HS Koh, CY Chang, SB Jeon, HJ Yoon, YH Ahn, HS Kim, IH Kim, SH Jeon, RS Johnson, EJ Park
Nature Communications 2015
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection
AE Lin, FC Beasley, J Olson, N Keller, RA Shalwitz, TJ Hannan, SJ Hultgren, V Nizet, KJ Satchell
PLoS pathogens 2015
M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling
WJ Lee, S Tateya, AM Cheng, N Rizzo-DeLeon, NF Wang, P Handa, CL Wilson, AW Clowes, IR Sweet, K Bomsztyk, MW Schwartz, F Kim
Diabetes 2015
Atelectasis causes alveolar hypoxia-induced inflammation during uneven mechanical ventilation in rats
K Tojo, Y Nagamine, T Yazawa, T Mihara, Y Baba, S Ota, T Goto, K Kurahashi
Intensive Care Medicine Experimental 2015
Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa
EL Campbell, SP Colgan
Journal of leukocyte biology 2015
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
M Schneider, JM Harnoss, MJ Strowitzki, P Radhakrishnan, L Platzer, JC Harnoss, T Hank, J Cai, A Ulrich
Hypoxia 2015
NF-κB and HIF crosstalk in immune responses
L D'Ignazio, D Bandarra, S Rocha
FEBS Journal 2015
Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens
CN LaRock, V Nizet
Biochimica et Biophysica Acta (BBA) - Biomembranes 2015
HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
A Tawakol, P Singh, M Mojena, M Pimentel-Santillana, H Emami, M MacNabb, JH Rudd, J Narula, JA Enriquez, PG Traves, M Fernandez-Velasco, R Bartrons, P Martin-Sanz, ZA Fayad, A Tejedor, L Bosca
Arteriosclerosis, thrombosis, and vascular biology 2015
The Ischemic Environment Drives Microglia and Macrophage Function
S Fumagalli, C Perego, F Pischiutta, ER Zanier, MG Simoni
Frontiers in neurology 2015
Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit
S Bozonet, A Carr, J Pullar, M Vissers
Nutrients 2015
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
B Kelly, LA O'Neill
Cell Research 2015
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
D Fan, LA Coughlin, MM Neubauer, J Kim, MS Kim, X Zhan, TR Simms-Waldrip, Y Xie, LV Hooper, AY Koh
Nature Medicine 2015
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
A Hammami, T Charpentier, M Smans, S Stäger, EY Denkers
PLoS pathogens 2015
Proteolytic Cleavage of AMPK  and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1  Expression in Leukocytes
Z Zhang, LF Amorosa, SM Coyle, MA Macor, SE Lubitz, JL Carson, MJ Birnbaum, LY Lee, B Haimovich
Journal of immunology (Baltimore, Md. : 1950) 2015
Hypoxia-inducible factors regulate T cell metabolism and function
AT Phan, AW Goldrath
Molecular Immunology 2015
Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas
MS Cardoso, TM Silva, M Resende, R Appelberg, M Borges, S Ehrt
Infection and immunity 2015
Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
PM Elks, SA Renshaw, AH Meijer, SR Walmsley, FJ van Eeden
Disease models & mechanisms 2015
Hypoxia promotes Mycobacterium tuberculosis-specific up-regulation of granulysin in human T cells
SF Zenk, M Vollmer, E Schercher, S Kallert, J Kubis, S Stenger
Medical Microbiology and Immunology 2015
Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection
Wagage S, Hunter CA
Current medicinal chemistry 2015
Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib
HS Jun, DA Weinstein, YM Lee, BC Mansfield, JY Chou
Blood 2014
Macrophage-mediated response to hypoxia in disease
C Murdoch, S Tazzyman, J Harrison, J Yeomans, M Muthana
Hypoxia 2014
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
HK Eltzschig, DL Bratton, SP Colgan
Nature Reviews Drug Discovery 2014
Metabolic Regulation of Immune Responses
K Ganeshan, A Chawla
Annual Review of Immunology 2014
Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess
J Pacheco-Yepez, RA Jarillo-Luna, M Gutierrez-Meza, E Abarca-Rojano, BA Larsen, R Campos-Rodriguez
BioMed Research International 2014
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases
T Bhandari, V Nizet
Infectious Diseases and Therapy 2014
Orchestration of Angiogenesis by Immune Cells
A Bruno, A Pagani, L Pulze, A Albini, K Dallaglio, DM Noonan, L Mortara
Frontiers in Oncology 2014
Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model
PM Elks, M der Vaart, V Hensbergen, E Schutz, MJ Redd, E Murayama, HP Spaink, AH Meijer
PloS one 2014
Epigenetic coordination of acute systemic inflammation: potential therapeutic targets
V Vachharajani, T Liu, CE McCall
Expert Review of Clinical Immunology 2014
Investigating the real role of HIF-1 and HIF-2 in iron recycling by macrophages
JR Mathieu, M Heinis, S Zumerle, S Delga, AL Bon, C Peyssonnaux
Haematologica 2014
Metabolic Reprograming in Macrophage Polarization
S Galván-Peña, LA O’Neill
Frontiers in immunology 2014
Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection
KM Shepardson, A Jhingran, A Caffrey, JJ Obar, BT Suratt, BL Berwin, TM Hohl, RA Cramer, S Gaffen
PLoS pathogens 2014
Th1/Th2 Paradigm Extended: Macrophage Polarization as an Unappreciated Pathogen-Driven Escape Mechanism?
E Muraille, O Leo, M Moser
2014
The Regulation of Pulmonary Inflammation by the Hypoxia-Inducible Factor–Hydroxylase Oxygen-Sensing Pathway
MK Whyte, SR Walmsley
Annals of the American Thoracic Society 2014
Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia
J Harki, A Sana, D Noord, PJ van Diest, P der Groep, EJ Kuipers, LM Moons, K Biermann, ET Tjwa
Virchows Archiv 2014
HIF Transcription Factors, Inflammation, and Immunity
A Palazon, AW Goldrath, V Nizet, RS Johnson
Immunity 2014
Bile Acids Repress Hypoxia-Inducible Factor 1 Signaling and Modulate the Airway Immune Response
C Legendre, FJ Reen, DF Woods, MJ Mooij, C Adams, F O'Gara
Infection and immunity 2014
Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing
C Scott, J Bonner, D Min, P Boughton, R Stokes, KM Cha, SN Walters, K Maslowski, F Sierro, ST Grey, S Twigg, S McLennan, JE Gunton
American journal of physiology. Cell physiology 2014
HIF-mediated innate immune responses: cell signaling and therapeutic implications
S Walmsley, A Harris, AA Thompson, MK Whyte
Hypoxia 2014
Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages
A Mahnke, RJ Meier, V Schatz, J Hofmann, K Castiglione, U Schleicher, OS Wolfbeis, C Bogdan, J Jantsch
Journal of Investigative Dermatology 2014
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
AA Thompson, PM Elks, HM Marriott, S Eamsamarng, KR Higgins, A Lewis, L Williams, S Parmar, G Shaw, EE McGrath, F Formenti, FJ van Eeden, VL Kinnula, CW Pugh, I Sabroe, DH Dockrell, ER Chilvers, PA Robbins, MJ Percy, MC Simon, RS Johnson, SA Renshaw, MK Whyte, SR Walmsley
Blood 2013
HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium
T Eckle, K Brodsky, M Bonney, T Packard, J Han, CH Borchers, TJ Mariani, DJ Kominsky, M Mittelbronn, HK Eltzschig, AJ Vidal-Puig
PLoS Biology 2013
Redox control of inflammation in macrophages
B Brüne, N Dehne, N Grossmann, M Jung, D Namgaladze, T Schmid, A Knethen, A Weigert
Antioxidants & Redox Signaling 2013
Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells
A Walczak-Drzewiecka, A Salkowska, M Ratajewski, J Dastych
Immunogenetics 2013
HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination
T Bhandari, J Olson, RS Johnson, V Nizet
Journal of Molecular Medicine 2013
Cellular Metabolic Regulators: Novel Indicators of Low-Grade Inflammation in Humans
B Haimovich, Z Zhang, JE Calvano, SE Calvano, A Kumar, MA Macor, S Corbett, SM Coyle, SF Lowry
Annals of Surgery 2013
HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis
EA Berger, SA McClellan, KS Vistisen, LD Hazlett
PLoS pathogens 2013
Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions
SK Schmidt, S Ebel, E Keil, C Woite, JF Ernst, AE Benzin, J Rupp, W Däubener
PloS one 2013
Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism
PM Elks, S Brizee, M der Vaart, SR Walmsley, FJ van Eeden, SA Renshaw, AH Meijer
PLoS pathogens 2013
Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment
E Leire, J Olson, H Isaacs, V Nizet, A Hollands
Journal of Inflammation 2013
Cobalt-alloy implant debris induce HIF-1α hypoxia associated responses: a mechanism for metal-specific orthopedic implant failure
L Samelko, MS Caicedo, SJ Lim, C Della-Valle, J Jacobs, NJ Hallab
PloS one 2013
The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
PM Gallo, S Gallucci
Frontiers in immunology 2013
The expanding world of extracellular traps: not only neutrophils but much more
O Goldmann, E Medina
Frontiers in immunology 2013
Hypoxia-Inducible Factor 1-Regulated Lysyl Oxidase Is Involved in Staphylococcus aureus Abscess Formation
C Beerlage, J Greb, D Kretschmer, M Assaggaf, PC Trackman, ML Hansmann, M Bonin, JA Eble, A Peschel, B Brüne, VA Kempf, JL Flynn
Infection and immunity 2013
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis
J Kiss, M Mollenhauer, SR Walmsley, J Kirchberg, P Radhakrishnan, T Niemietz, J Dudda, G Steinert, MK Whyte, P Carmeliet, M Mazzone, J Weitz, M Schneider
Journal of immunology (Baltimore, Md. : 1950) 2012
Pseudomonas aeruginosa Alkyl Quinolones Repress Hypoxia-Inducible Factor 1 (HIF-1) Signaling through HIF-1α Degradation
C Legendre, FJ Reen, MJ Mooij, GP McGlacken, C Adams, F O'Gara, BA McCormick
Infection and immunity 2012
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process
D Ortiz-Masià, I Díez, S Calatayud, C Hernández, J Cosín-Roger, J Hinojosa, JV Esplugues, MD Barrachina
PloS one 2012
Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury
H Kobayashi, V Gilbert, Q Liu, PP Kapitsinou, TL Unger, J Rha, S Rivella, D Schlöndorff, VH Haase
Journal of immunology (Baltimore, Md. : 1950) 2012
The pleiotropic effects of erythropoietin in infection and inflammation
M Nairz, T Sonnweber, A Schroll, I Theurl, G Weiss
Microbes and infection / Institut Pasteur 2012
Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis
S Konisti, S Kiriakidis, EM Paleolog
Nature Reviews Rheumatology 2012
The updated biology of hypoxia-inducible factor
SN Greer, JL Metcalf, Y Wang, M Ohh
The EMBO Journal 2012
EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways
LG Luhachack, O Visvikis, AC Wollenberg, A Lacy-Hulbert, LM Stuart, JE Irazoqui
PLoS pathogens 2012
Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury
Y Wang, Y Liu, A Sidhu, Z Ma, C McClain, W Feng
American journal of physiology. Gastrointestinal and liver physiology 2012
Hypoxia and fungal pathogenesis: to air or not to air?
N Grahl, KM Shepardson, D Chung, RA Cramer
Eukaryotic cell 2012
Hypoxia-Mediated Impairment of the Mitochondrial Respiratory Chain Inhibits the Bactericidal Activity of Macrophages
M Wiese, RG Gerlach, I Popp, J Matuszak, M Mahapatro, K Castiglione, D Chakravortty, C Willam, M Hensel, C Bogdan, J Jantsch, BA McCormick
Infection and immunity 2012
Molecular oxygen sensing: implications for visceral surgery
J Kiss, J Kirchberg, M Schneider
Langenbeck's Archives of Surgery 2012
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
CY Okumura, A Hollands, DN Tran, J Olson, S Dahesh, M Köckritz-Blickwede, W Thienphrapa, C Corle, SN Jeung, A Kotsakis, RA Shalwitz, RS Johnson, V Nizet
Journal of Molecular Medicine 2012
Kruppel-Like Factors and Vascular Inflammation: Implications for Atherosclerosis
MA Alaiti, G Orasanu, D Tugal, Y Lu, MK Jain
Current Atherosclerosis Reports 2012
Intracellular Pathogen Leishmania donovani Activates Hypoxia Inducible Factor-1 by Dual Mechanism for Survival Advantage within Macrophage
AK Singh, C Mukhopadhyay, S Biswas, VK Singh, CK Mukhopadhyay
PloS one 2012
Systemic VHL gene functions and the VHL disease
HL Bader, T Hsu
FEBS Letters 2012
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps
K Branitzki‑Heinemann, CY Okumura, L Völlger, Y Kawakami, T Kawakami, HY Naim, V Nizet, MV Köckritz‑Blickwede
Biochemical Journal 2012
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
LE Alexander, K Akong-Moore, S Feldstein, P Johansson, A Nguyen, EK McEachern, S Nicatia, AS Cowburn, J Olson, JY Cho, H Isaacs, RS Johnson, DH Broide, V Nizet
Journal of Molecular Medicine 2012
New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation
M Pelletier, TS Lepow, LK Billingham, MP Murphy, RM Siegel
Seminars in Immunology 2012
Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  
AM McInturff, MJ Cody, EA Elliott, JW Glenn, JW Rowley, MT Rondina, CC Yost
Blood 2012
Fueling the flame: bioenergy couples metabolism and inflammation
TF Liu, CM Brown, ME Gazzar, L McPhail, P Millet, A Rao, VT Vachharajani, BK Yoza, CE McCall
Journal of leukocyte biology 2012
Anti-inflammatory properties of histone deacetylase inhibitors: A mechanistic study
W Chong, Y Li, B Liu, Z Liu, T Zhao, DR Wonsey, C Chen, GC Velmahos, MA deMoya, DR King, AL Kung, HB Alam
The Journal of trauma 2012
Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP
KC Liao, J Mogridge, SR Blanke
Infection and immunity 2012
Von Hippel-Lindau Disease (VHL): A need for a murine model with retinal hemangioblastoma
Park S, Chan CC
Histology and histopathology 2012
Prolyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Sarah Walmsley, Edwin Chilvers, Alfred Thompson, Kathryn Vaughan, Helen Marriott, Lisa Parker, Gary Shaw, Selina Parmar, Martin Schneider, Ian Sabroe, David Dockrell, Marta Milo, Cormac Taylor, Randall Johnson, Christopher Pugh, Peter Ratcliffe, Patrick H. Maxwell, Peter Carmeliet, Moira Whyte
Journal of Clinical Investigation 2011
Regulation of Hypoxia-Inducible Factor-1α and Erythropoiesis by Herpesvirus Entry Mediator in Mice
Sakoda Yukimi, Sudarshan Anand, Yuming Zhao, JangJune Park, Yingjia Liu, Atsuo Kuramasu, Nico van Rooijen, Ling Chen, Scott Strome, Wayne W. Hancock, Lieping Chen, Koji Tamada
Journal of Clinical Investigation 2011
Cholinergic Regulation of Keratinocyte Innate Immunity and Permeability Barrier Integrity: New Perspectives in Epidermal Immunity and Disease
BJ Curtis, KA Radek
Journal of Investigative Dermatology 2011
Interactions between Nitric Oxide and Hypoxia-Inducible Factor Signaling Pathways in Inflammatory Disease
N Olson, A der Vliet
Nitric Oxide 2011
Hypoxia and Metabolic Factors that Influence IBD Pathogenesis
LE Glover, SP Colgan
Gastroenterology 2011
Hypoxia and Inflammation
HK Eltzschig, P Carmeliet
New England Journal of Medicine 2011
Macrophages, Meta-Inflammation, and Immuno-Metabolism
H Shapiro, A Lutaty, A Ariel
TheScientificWorldJournal 2011
Implications of hypoxic microenvironments during invasive aspergillosis
SJ Wezensky, RA Cramer
Medical mycology : official publication of the International Society for Human and Animal Mycology 2011
Hypoxia: a double-edged sword of immunity
A Sica, G Melillo, L Varesio
Journal of Molecular Medicine 2011
The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
GH Mahabeleshwar, D Kawanami, N Sharma, Y Takami, G Zhou, H Shi, L Nayak, D Jeyaraj, R Grealy, M White, R McManus, T Ryan, P Leahy, Z Lin, SM Haldar, GB Atkins, HR Wong, JB Lingrel, MK Jain
Immunity 2011
Targeting the host–pathogen interface for treatment of Staphylococcus aureus infection
B Park, GY Liu
Seminars in Immunopathology 2011
A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis
TW van Hal, L Bon, TR Radstake
International Journal of Rheumatology 2011
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis
GH Mahabeleshwar, MA Qureshi, Y Takami, N Sharma, JB Lingrel, MK Jain
The Journal of biological chemistry 2011
Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections
AS Zinkernagel, P Hruz, S Uchiyama, M Köckritz-Blickwede, RA Schuepbach, T Hayashi, DA Carson, V Nizet
Journal of Innate Immunity 2011
Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats
D Popa, Z Fu, A Go, FL Powell
Respiratory Physiology & Neurobiology 2011
The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity
EM Sparkenbaugh, Y Saini, KK Greenwood, JJ LaPres, JP Luyendyk, BL Copple, JF Maddox, PE Ganey, RA Roth
The Journal of pharmacology and experimental therapeutics 2011
Hypoxia-inducible factor-2alpha regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Imtiyaz, Emily Williams, Michele Hickey, Shetal Patel, Amy Durham, Li J Yuan, Rachel Hammond, Phyllis Gimotty, Brian Keith, M. Celeste Simon
Journal of Clinical Investigation 2010
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens
N Werth, C Beerlage, C Rosenberger, AS Yazdi, M Edelmann, A Amr, W Bernhardt, C Eiff, K Becker, A Schäfer, A Peschel, VA Kempf
PloS one 2010
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
N Takeda, EL O'Dea, A Doedens, J Kim, A Weidemann, C Stockmann, M Asagiri, MC Simon, A Hoffmann, RS Johnson
Genes & development 2010
Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation
I Díez, S Calatayud, C Hernández, E Quintana, JE O'Connor, JV Esplugues, MD Barrachina
British Journal of Pharmacology 2010
Iron Homeostasis and the Inflammatory Response
M Wessling-Resnick
Annual Review of Nutrition 2010
Diverse Effects of Hypoxia on Tumor Progression
MC Simon
2010
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
AL Doedens, C Stockmann, MP Rubinstein, D Liao, N Zhang, DG DeNardo, LM Coussens, M Karin, AW Goldrath, RS Johnson
Cancer research 2010
Iron and the immune system
RJ Ward, RR Crichton, DL Taylor, LD Corte, SK Srai, DT Dexter
Journal of Neural Transmission 2010
Modulation of NF-κB and Hypoxia-Inducible Factor−1 by S-Nitrosoglutathione Does Not Alter Allergic Airway Inflammation in Mice
N Olson, DI Kasahara, M Hristova, R Bernstein, Y Janssen-Heininger, A der Vliet
American journal of respiratory cell and molecular biology 2010
Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions
R Spirig, S Djafarzadeh, T Regueira, SG Shaw, C Garnier, J Takala, SM Jakob, R Rieben, PM Lepper
PloS one 2010
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
AJ Majmundar, WJ Wong, MC Simon
Molecular Cell 2010
Reactive Oxygen Species Enhance TLR10 Expression in the Human Monocytic Cell Line THP-1
D Kim, YJ Kim, HS Koh, TY Jang, HE Park, JY Kim
International journal of molecular sciences 2010
Microglia in ischemic brain injury
JR Weinstein, IP Koerner, T Möller
Future Neurology 2010
Toxoplasma gondii Activates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling*
M Wiley, KR Sweeney, DA Chan, KM Brown, C McMurtrey, EW Howard, AJ Giaccia, IJ Blader
The Journal of biological chemistry 2010
Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils
NN McGovern, AS Cowburn, L Porter, SR Walmsley, C Summers, AA Thompson, S Anwar, LC Willcocks, MK Whyte, AM Condliffe, ER Chilvers
Journal of immunology (Baltimore, Md. : 1950) 2010
Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage: Ischemic Stroke and HIF-1α Induces Nix and VEGF
SH Yeh, LC Ou, PW Gean, JJ Hung, WC Chang
Brain Pathology 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Adenosine: An Old Drug Newly Discovered
HK Eltzschig
Anesthesiology 2009
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
P Fraisl, J Aragonés, P Carmeliet
Nature Reviews Drug Discovery 2009
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
P Rosenberger, JM Schwab, V Mirakaj, E Masekowsky, A Mager, JC Morote-Garcia, K Unertl, HK Eltzschig
Nature Immunology 2009
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
HK Eltzschig, J Rivera-Nieves, SP Colgan
Expert Opinion on Therapeutic Targets 2009
Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections
A Nijnik, R Hancock
Emerging Health Threats Journal 2009
Interdependence of hypoxic and innate immune responses
V Nizet, RS Johnson
Nature Reviews Immunology 2009
Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation
CH Hsieh, EA Nickel, JT Hsu, MG Schwacha, KI Bland, IH Chaudry
Annals of Surgery 2009
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans
A Bellier, CS Chen, CY Kao, HN Cinar, RV Aroian
PLoS pathogens 2009
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
WM Bernhardt, U Gottmann, F Doyon, B Buchholz, V Campean, J Schödel, A Reisenbuechler, S Klaus, M Arend, L Flippin, C Willam, MS Wiesener, B Yard, C Warnecke, KU Eckardt
Proceedings of the National Academy of Sciences 2009
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
HY Fang, R Hughes, C Murdoch, SB Coffelt, SK Biswas, AL Harris, RS Johnson, HZ Imityaz, MC Simon, E Fredlund, FR Greten, J Rius, CE Lewis
Blood 2009
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
SR Walmsley, ER Chilvers, MK Whyte
Arthritis Research & Therapy 2009
Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1
K Shirato, T Kizaki, T Sakurai, J Ogasawara, Y Ishibashi, T Iijima, C Okada, I Noguchi, K Imaizumi, N Taniguchi, H Ohno
Pflügers Archiv - European Journal of Physiology 2009
The multiple actions of NO
Y Gao
Pflügers Archiv - European Journal of Physiology 2009
Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity
L Wang, BJ Cherayil
Journal of Innate Immunity 2009
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling
M Scortegagna, C Cataisson, RJ Martin, DJ Hicklin, RD Schreiber, SH Yuspa, JM Arbeit
Blood 2008
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
HA Haeberle, C Dürrstein, P Rosenberger, YM Hosakote, J Kuhlicke, VA Kempf, RP Garofalo, HK Eltzschig
PloS one 2008
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells
Z Li, Z Lai, K Ya, D Fang, YW Ho, Y Lei, QZ Ming
Journal of Cellular and Molecular Medicine 2008
Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection
MM Peterson, JL Mack, PR Hall, AA Alsup, SM Alexander, EK Sully, YS Sawires, AL Cheung, M Otto, HD Gresham
Cell Host & Microbe 2008
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
J Rius, M Guma, C Schachtrup, K Akassoglou, AS Zinkernagel, V Nizet, RS Johnson, GG Haddad, M Karin
Nature 2008
Acute inactivation of the VHL gene contributes to protective effects of ischemic preconditioning in the mouse kidney
M Iguchi, Y Kakinuma, A Kurabayashi, T Sato, T Shuin, SB Hong, LS Schmidt, M Furihata
Nephron. Experimental nephrology 2008
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body
FL Powell
American journal of physiology. Lung cellular and molecular physiology 2008
IKKbeta/NF-kappaB and the miscreant macrophage
AM Timmer, V Nizet
Journal of Experimental Medicine 2008
Complex regulation of human cathelicidin gene expression: novel splice variants and 5'UTR negative regulatory element
HZ Elloumi, SM Holland
Molecular Immunology 2008
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
J Kuhlicke, JS Frick, JC Morote-Garcia, P Rosenberger, HK Eltzschig
PloS one 2007
Regulation of HIF-1alpha stability through S-nitrosylation
F Li, P Sonveaux, ZN Rabbani, S Liu, B Yan, Q Huang, Z Vujaskovic, MW Dewhirst, CY Li
Molecular Cell 2007
Hypoxia inducible factor (HIF) function in innate immunity and infection
AS Zinkernagel, RS Johnson, V Nizet
Journal of Molecular Medicine 2007
Genetic Characterization and Virulence Role of the RALP3/LSA Locus Upstream of the Streptolysin S Operon in Invasive M1T1 Group A Streptococcus
LA Kwinn, A Khosravi, RK Aziz, AM Timmer, KS Doran, M Kotb, V Nizet
Journal of bacteriology 2007
Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
HK Eltzschig, M Faigle, S Knapp, J Karhausen, J Ibla, P Rosenberger, KC Odegard, PC Laussen, LF Thompson, SP Colgan
Blood 2006
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection
P Mydel, Y Takahashi, H Yumoto, M Sztukowska, M Kubica, FC 3rd, DM Kurtz, J Travis, LV Collins, KA Nguyen, CA Genco, J Potempa
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MG Espey
Free radical biology & medicine 2006
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
C Peyssonnaux, AS Zinkernagel, V Datta, X Lauth, RS Johnson, V Nizet
Blood 2006
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
D Vats, L Mukundan, JI Odegaard, L Zhang, KL Smith, CR Morel, RA Wagner, DR Greaves, PJ Murray, A Chawla
Cell Metabolism 2006
Hypoxic adaptation during development: relation to pattern of neurological presentation and cognitive disability
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Developmental science 2006
Loss of VHL Confers Hypoxia-Inducible Factor (HIF)-Dependent Resistance to Vesicular Stomatitis Virus: Role of HIF in Antiviral Response
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Journal of Clinical Investigation 2005
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction
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Proceedings of the National Academy of Sciences 2005

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