There has been some debate about the disease-invoking potential of Staphylococcus aureus strains and whether invasive disease is associated with particularly virulent genotypes, or “superbugs.” A study in this issue of the JCI describes the genotyping of a large collection of nonclinical, commensal S. aureus strains from healthy individuals in a Dutch population. Extensive study of their genetic relatedness by amplified restriction fragment typing and comparison with strains that are associated with different types of infections revealed that the S. aureus population is clonal and that some strains have enhanced virulence. This is discussed in the context of growing interest in the mechanisms of bacterial colonization, antibiotic resistance, and novel vaccines.
Timothy J. Foster
Title and authors | Publication | Year |
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Nasal colonization of methicillin resistant Staphylococcus aureus in Ethiopia: a systematic review and meta-analysis
A Reta, A Mengist, A Tesfahun |
Annals of clinical microbiology and antimicrobials | 2019 |
The Staphylococcus aureus Transcriptome during Cystic Fibrosis Lung Infection.
Ibberson CB, Whiteley M |
mBio | 2019 |
Management and prevention of drug resistant infections in burn patients.
Vinaik R, Barayan D, Shahrokhi S, Jeschke MG |
Expert Review of Anti-infective Therapy | 2019 |
Microbial epidemiology and antimicrobial resistance patterns of wound infection in Ethiopia: a meta-analysis of laboratory-based cross-sectional studies.
Sisay M, Worku T, Edessa D |
2019 | |
Single mutations in BraRS confer high resistance against nisin A in Staphylococcus aureus.
Arii K, Kawada-Matsuo M, Oogai Y, Noguchi K, Komatsuzawa H |
MicrobiologyOpen | 2019 |