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Citations to this article

FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov, … , S. Richard Jaskunas, Armen B. Shanafelt
Alexei Kharitonenkov, … , S. Richard Jaskunas, Armen B. Shanafelt
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1627-1635. https://doi.org/10.1172/JCI23606.
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Research Article Metabolism Article has an altmetric score of 18

FGF-21 as a novel metabolic regulator

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Abstract

Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here we describe a potential novel therapeutic agent for this disease, FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes. FGF-21–transgenic mice were viable and resistant to diet-induced obesity. Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice. These effects persisted for at least 24 hours following the cessation of FGF-21 administration. Importantly, FGF-21 did not induce mitogenicity, hypoglycemia, or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

Authors

Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Koester, Amy M. Ford, Radmila Micanovic, Elizabeth J. Galbreath, George E. Sandusky, Lisa J. Hammond, Julie S. Moyers, Rebecca A. Owens, Jesper Gromada, Joseph T. Brozinick, Eric D. Hawkins, Victor J. Wroblewski, De-Shan Li, Farrokh Mehrbod, S. Richard Jaskunas, Armen B. Shanafelt

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Targeting Hepatic Serine-Arginine Protein Kinase 2 Ameliorates Alcohol-Associated Liver Disease by Alternative Splicing Regulation of Lipogenesis
Guannan Li, Hanqing Chen, Feng Shen, Steven Blake Smithson, Gavyn Lee Shealy, Qinggong Ping, Zerong Liang, Jingyan Han, Andrew Adams, Yu Li, Dechun Feng, Bin Gao, Masahiro Morita, Xianlin Han, Tim Huang, Nicolas Musi, Mengwei Zang
Hepatology 2023
Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine
Tan H, Yue T, Chen Z, Wu W, Xu S, Weng J
International journal of biological sciences 2023
Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency.
Jung YE, Lee KW, Cho JH, Bae DW, Jeong BG, Jung YJ, Park SB, An YJ, Kim K, Lee GS, Kang LW, Moon JH, Lee JH, Kim EK, Yim HS, Cha SS
Scientific Reports 2023
Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
Corbee RJ, van Everdingen DL, Kooistra HS, Penning LC
Frontiers in Veterinary Science 2023
Liver fibroblast growth factor 21 (FGF21) is required for the full anorectic effect of the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets
Thao DV Le, Payam Fathi, Amanda Watters, Blair Ellis, Nadejda Bozadjieva-Kramer, Misty Perez, Andrew Sullivan, Jesse Rose, Laurie Baggio, Jacqueline Koehler, Jennifer Brown, Michelle Bales, Kaitlyn Nwaba, Jonathan Campbell, Daniel Drucker, Matthew Potthoff, Randy Seeley, Julio Ayala
Molecular Metabolism 2023
Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
Fritsche K, Ziková-Kloas A, Marx-Stoelting P, Braeuning A
International journal of molecular sciences 2023
The Diagnostic Role of FGF 21 in Endometrial Cancer and Other Pathologies of the Uterine Corpus
Jagodzińska A, Chudecka-Głaz A, Michalczyk K, Pius-Sadowska E, Wieder-Huszla S, Jurczak A, Machaliński B
Diagnostics 2023
Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
Huang W, Zhang J, Zou J, Wang X, Xu H, Guan J, Yi H, Liu S, Yin S
iScience 2023
Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue.
van Beek S, Hashim D, Bengtsson T, Hoeks J
International Journal of Obesity 2023
Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity.
Lőrincz H, Somodi S, Ratku B, Harangi M, Paragh G
Metabolites 2023
Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial
Brown EA, Minnich A, Sanyal AJ, Loomba R, Du S, Schwarz J, Ehman RL, Karsdal M, Leeming DJ, Cizza G, Charles ED
2023
Fibroblast Growth Factors for Nonalcoholic Fatty Liver Disease: Opportunities and Challenges.
Tian H, Zhang S, Liu Y, Wu Y, Zhang D
International journal of molecular sciences 2023
FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway.
Kan S, Pi C, Zhang L, Guo D, Niu Z, Liu Y, Duan M, Pu X, Bai M, Zhou C, Zhang D, Xie J
Cell communication and signaling : CCS 2023
New insights into the inter-organ crosstalk mediated by ChREBP
Carbinatti T, Régnier M, Parlati L, Benhamed F, Postic C
Frontiers in Endocrinology 2023
Fibroblast growth factor 21 and prognosis of patients with cardiovascular disease: A meta-analysis
Yan B, Ma S, Yan C, Han Y
Frontiers in Endocrinology 2023
Short-Term Decreasing and Increasing Dietary BCAA Have Similar, but Not Identical Effects on Lipid and Glucose Metabolism in Lean Mice
Sun Y, Sun B, Wang Z, Lv Y, Ma Q
International journal of molecular sciences 2023
The effect of fibroblast growth factor 21 on a mouse model of bovine viral diarrhea
Zhao D, Song YH, Song JM, Shi K, Li JM, Diao NC, Zong Y, Zeng FL, Du R
Frontiers in Veterinary Science 2023
The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases
Zanini G, Selleri V, Malerba M, Solodka K, Sinigaglia G, Nasi M, Mattioli AV, Pinti M
Antioxidants 2023
Fibroblast growth factor 21 may be a strong biomarker for renal outcomes: a meta-analysis.
Yong G, Li L, Hu S
Renal Failure 2023
Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
Song T, Qin W, Lai Z, Li H, Li D, Wang B, Deng W, Wang T, Wang L, Huang R
Cell Research 2023
Leucine supplementation in maternal high-fat diet alleviated adiposity and glucose intolerance of adult mice offspring fed a postweaning high-fat diet.
Kim J, Kim J, Kwon YH
Lipids in Health and Disease 2023
High circulating fibroblast growth factor-21 levels as a screening marker in fatty pancreas patients.
Han F, Yin L, Yu X, Xu R, Tian M, Liu X, Zhou L, Hu L, Gong W, Xiao W, Lu G, Yao G, Ding Y
PeerJ 2023
ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance
Gomes D, Sobolewski C, Conzelmann S, Schaer T, Lefai E, Alfaiate D, Tseligka ED, Goossens N, Tapparel C, Negro F, Foti M, Clément S
Scientific Reports 2023
Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
Kim H, Jung J, Park S, Joo Y, Lee S, Sim J, Choi J, Lee H, Hwang G, Lee S
International journal of molecular sciences 2023
FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice
Liu L, Li F, Shao T, Zhang L, Lee J, Dryden G, McClain CJ, Zhao C, Feng W
Nutrients 2023
The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
Finney AC, Das S, Kumar D, McKinney MP, Cai B, Yurdagul A Jr, Rom O
Frontiers in Cardiovascular Medicine 2023
Circulating FGF21 Concentration, Fasting Plasma Glucose, and the Risk of Type 2 Diabetes: Results From the PREVEND Study.
Post A, Dam WA, Sokooti S, Groothof D, Gloerich J, van Gool AJ, Kremer D, Gansevoort RT, van den Born J, Kema IP, Franssen CFM, Dullaart RPF, Bakker SJL
The Journal of clinical endocrinology and metabolism 2023
The fibroblast growth factor system in cognitive disorders and dementia
Zhai W, Zhang T, Jin Y, Huang S, Xu M, Pan J
Frontiers in neuroscience 2023
Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway.
Ding P, Yang R, Li C, Fu HL, Ren GL, Wang P, Zheng DY, Chen W, Yang LY, Mao YF, Yuan HB, Li YH
Critical Care 2023
Adipokines as Clinically Relevant Therapeutic Targets in Obesity
Würfel M, Blüher M, Stumvoll M, Ebert T, Kovacs P, Tönjes A, Breitfeld J
Biomedicines 2023
Association of NAFLD with FGF21 Polygenic Hazard Score, and Its Interaction with Protein Intake Level in Korean Adults
Lee HJ, Shon J, Park YJ
Nutrients 2023
The Effects of Rumen-Protected Choline and Rumen-Protected Nicotinamide on Liver Transcriptomics in Periparturient Dairy Cows
Du X, Cui Z, Zhang R, Zhao K, Wang L, Yao J, Liu S, Cai C, Cao Y
Metabolites 2023
Valproate-Induced Metabolic Syndrome
Shnayder NA, Grechkina VV, Trefilova VV, Efremov IS, Dontceva EA, Narodova EA, Petrova MM, Soloveva IA, Tepnadze LE, Reznichenko PA, Al-Zamil M, Altynbekova GI, Strelnik AI, Nasyrova RF
Biomedicines 2023
Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho
Aaldijk AS, Verzijl CR, Jonker JW, Struik D
Frontiers in Endocrinology 2023
Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis.
Garruti G, Baj J, Cignarelli A, Perrini S, Giorgino F
Frontiers in Endocrinology 2023
Structural basis for FGF hormone signalling.
Chen L, Fu L, Sun J, Huang Z, Fang M, Zinkle A, Liu X, Lu J, Pan Z, Wang Y, Liang G, Li X, Chen G, Mohammadi M
Nature 2023
Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level
Li X, Zheng K, Gu W, Hou X, Guan Y, Liu L, Hou L, Geng J, Song G
2023
Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months
Lu C, Jin L, Bi J, Jin H, You X, Peng L, Fan H, Wang H, Wang L, Fan Z, Wang X, Liu B
Frontiers in pharmacology 2023
Evaluation of endpoints for the study and diagnosis of mitochondrial toxicity and disease: a narrative review.
Gharti P, Fletcher JF, Chapman KE
Mutagenesis 2023
Serum Fibroblast Growth Factor-21 Discriminates Between Decompensated Alcohol-Associated Cirrhosis and Severe Alcohol-Associated Hepatitis
McLean Diaz P, Vannier A, Joshi AD, Mahle RE, Przybyszewski EM, Corey K, Chung RT, Luther J, Goodman RP, Schaefer EA
Clinical and Translational Gastroenterology 2023
Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21.
Klein Hazebroek M, Laterveer R, Kutschke M, Ramšak Marčeta V, Barthem CS, Keipert S
Scientific Reports 2023
Exploring the correlation between serum fibroblast growth factor-21 levels and Sarcopenia: a systematic review and meta-analysis.
Liu H, He X, Deng XY, Yan JL
BMC musculoskeletal disorders 2023
Peelable Microneedle Patches Deliver Fibroblast Growth Factors to Repair Skin Photoaging Damage
Yang G, Hu S, Jiang H, Cheng K
Nanotheranostics 2023
CRISPRa-based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning.
Zhu H, Liu D, Sui M, Zhou M, Wang B, Qi Q, Wang T, Zhang G, Wan F, Zhang B
Clinical and Translational Medicine 2023
Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy
Amatya R, Lee D, Min KA, Shin MC
Pharmaceutics 2023
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Vankrunkelsven W, Thiessen S, Derde S, Vervoort E, Derese I, Pintelon I, Matheussen H, Jans A, Goossens C, Langouche L, Van den Berghe G, Vanhorebeek I
Skeletal Muscle 2023
TNIK is a conserved regulator of glucose and lipid metabolism in obesity
Pham TC, Dollet L, Ali MS, Raun SH, Møller LL, Jafari A, Ditzel N, Andersen NR, Fritzen AM, Gerhart-Hines Z, Kiens B, Suomalainen A, Simpson SJ, Salling Olsen M, Kieser A, Schjerling P, Nieminen AI, Richter EA, Havula E, Sylow L
Science Advances 2023
Fibroblast growth factor 21 in metabolic syndrome
Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Zhao H, Han Y, Chen W, Li L, Xiao L, Sun L
Frontiers in Endocrinology 2023
Adipokines in atherosclerosis: unraveling complex roles
Luo J, He Z, Li Q, Lv M, Cai Y, Ke W, Niu X, Zhang Z
Frontiers in Cardiovascular Medicine 2023
The association of FGF-21 with the risk of newly diagnosed type-2 diabetes mellitus: a cross-sectional study in Southern China
You L, Hong X, Wu H, Liang D, Li F, Zheng D, Zhang X, Liu D, Chen Q, Yan L, Ren M, Wang W
BMC Endocrine Disorders 2023
Association of plasminogen activator inhibitor-1 and fibroblastic growth factor 21 in 3 groups of type 2 diabetes: Without overweight/obesity, free of insulin resistance, and without hepatosteatosis.
Takebe N, Hasegawa Y, Matsushita Y, Chiba H, Onodera K, Kinno H, Oda T, Nagasawa K, Segawa T, Takahashi Y, Okada K, Ishigaki Y
Medicine 2023
FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue.
Zhou Z, Zhang H, Tao Y, Zang J, Zhao J, Li H, Wang Y, Wang T, Zhao H, Wang F, Guo C, Zhu F, Mao H, Liu F, Zhang L, Wang Q
Redox Biology 2023
Long-term effects of a fat-directed FGF21 gene therapy in aged female mice.
Anderson JM, Arnold WD, Huang W, Ray A, Owendoff G, Cao L
Gene Therapy 2023
Hepatokines: the missing link in the development of insulin resistance and hyperandrogenism in PCOS?
Stefanaki K, Ilias I, Paschou SA, Karagiannakis DS
Hormones (Athens, Greece) 2023
Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice.
Kugler BA, Lourie J, Berger N, Lin N, Nguyen P, DosSantos E, Ali A, Sesay A, Rosen HG, Kalemba B, Hendricks GM, Houmard JA, Sesaki H, Gona P, You T, Yan Z, Zou K
Molecular Metabolism 2023
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis.
Jia W, Li Y, Cheung KCP, Zheng X
Science China Life Sciences 2023
Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice
Ishikawa H, Nagashima R, Kuno Y, Sasaki H, Kohda C, Iyoda M
2023
Metformin Protects Rat Skeletal Muscle from Physical Exercise-Induced Injury
Abbadessa G, Maniscalco E, Grasso L, Popara J, Di Scipio F, Franco F, Mancardi D, Pigozzi F, Borrione P, Berta GN, Racca S
Biomedicines 2023
The Interplay of Adipokines and Pancreatic Beta Cells in Metabolic Regulation and Diabetes
Kim J, Oh CM, Kim H
Biomedicines 2023
The Role of Organokines in Obesity and Type 2 Diabetes and Their Functions as Molecular Transducers of Nutrition and Exercise
Lim JY, Kim E
Metabolites 2023
The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway.
Wu K, Huang S, Zheng F, Liu Y
Acta Diabetologica 2023
Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction
Cefis M, Chaney R, Wirtz J, Méloux A, Quirié A, Leger C, Prigent-Tessier A, Garnier P
Frontiers in molecular neuroscience 2023
Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus and Type 2 Diabetes Mellitus
Gawlik K, Milewicz T, Pawlica-Gosiewska D, Trznadel-Morawska I, Solnica B
Journal of Diabetes Research 2023
Fibroblast Growth Factor 21 Has a Diverse Role in Energetic and Reproductive Physiological Functions of Female Beef Cattle
Prezotto LD, Keane JA, Cupp AS, Thorson JF
2023
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
Wang R, Wang J, Zhang Z, Ma B, Sun S, Gao L, Gao G
Molecular Medicine 2023
Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism
Li S, Chen J, Wei P, Zou T, You J
International journal of molecular sciences 2023
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
Delgado-Anglés A, Blasco-Roset A, Godoy-Nieto FJ, Cairó M, Villarroya F, Giralt M, Villarroya J
Journal of Physiology and Biochemistry 2023
Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men
Ji M, Cho C, Lee S
2023
The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review
Sadowska A, Poniedziałek-Czajkowska E, Mierzyński R
International journal of molecular sciences 2023
Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome
Feger M, Meier L, Strotmann J, Hoene M, Vogt J, Wisser A, Hirschle S, Kheim MJ, Hocher B, Weigert C, Föller M
Molecular Metabolism 2023
Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV
Ramirez Bustamante CE, Agarwal N, Cox AR, Hartig SM, Lake JE, Balasubramanyam A
Endocrine reviews 2023
FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
Aki Chaffin, Karlton Larson, Kuei-Pin Huang, Chih-Ting Wu, Nadejda Godoroja, Yanbin Fang, Devi Jayakrishnan, Karla Sauza, Landon Sims, Niloufar Mohajerani, Michael Goodson, Karen Ryan
JCI Insight 2022
Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
T Solomon, S Carter, J Haus, K Karstoft, S von Holstein-Rathlou, M Nielsen, M Gillum
PeerJ 2022
Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior
C Wu, A Chaffin, K Ryan
Journal of Clinical Medicine 2022
The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model
R Spann, C Morrison, L den Hartigh
Frontiers in Endocrinology 2022
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling
M Shimizu, R Sato
Cells 2022
Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk
F Berthou, C Sobolewski, D Abegg, M Fournier, C Maeder, D Dolicka, M de Sousa, A Adibekian, M Foti
International journal of molecular sciences 2022
Acute Deletion of the FOXO1-dependent Hepatokine FGF21 Does not Alter Basal Glucose Homeostasis or Lipolysis in Mice
J Sostre-Colón, M Gavin, D Santoleri, P Titchenell
Endocrinology 2022
Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease
T Puengel, H Liu, A Guillot, F Heymann, F Tacke, M Peiseler
International journal of molecular sciences 2022
Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance
L Qiao, L Men, S Yu, J Yao, Y Li, M Wang, Y Yu, N Wang, L Ran, Y Wu, J Du
Cell Death and Disease 2022
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Y Hsiao, I Shimizu, Y Yoshida, T Minamino
Inflammation and Regeneration 2022
Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication
M Furuhashi, Y Higashiura, A Sakai, M Koyama, M Tanaka, S Saitoh, K Shimamoto, H Ohnishi
Metabolites 2022
Maternal Blood-Based Protein Biomarkers in Relation to Abdominal Fat Distribution Measured by Ultrasound in Early Mid-Pregnancy
E Lindberger, A Wikström, I Poromaa, F Ahlsson
Reproductive sciences (Thousand Oaks, Calif.) 2022
Fibroblast growth factor-21 improves insulin action in nonlactating ewes.
Lamb CL, Giesy SL, McGuckin MM, Perfield JW 2nd, Butterfield A, Moniruzzaman M, Haughey NJ, McFadden JW, Boisclair YR
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2022
FGF4, A New Potential Regulator in Gestational Diabetes Mellitus.
Fan M, Pan T, Jin W, Sun J, Zhang S, Du Y, Chen X, Chen Q, Xu W, Choo SW, Zhu G, Chen Y, Zhou J
Frontiers in pharmacology 2022
Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids.
Tagawa R, Kobayashi M, Sakurai M, Yoshida M, Kaneko H, Mizunoe Y, Nozaki Y, Okita N, Sudo Y, Higami Y
International journal of molecular sciences 2022
Serum Fibroblast Growth Factor 21 Level Is Associated with Aortic Stiffness in Patients on Maintenance Hemodialysis.
Chiu LT, Hung CD, Lin L, Lin YL, Hsu BG
International Journal of Hypertension 2022
Spontaneous Browning of White Adipose Tissue Improves Angiogenesis and Reduces Macrophage Infiltration After Fat Grafting in Mice.
Lin J, Zhu S, Liao Y, Liang Z, Quan Y, He Y, Cai J, Lu F
Frontiers in Cell and Developmental Biology 2022
Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice.
Bartesaghi S, Wallenius K, Hovdal D, Liljeblad M, Wallin S, Dekker N, Barlind L, Davies N, Seeliger F, Winzell MS, Patel S, Theisen M, Brito L, Bergenhem N, Andersson S, Peng XR
2022
Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases
Jia MQ, Guan CX, Tao JH, Zhou Y
Oxidative medicine and cellular longevity 2022
AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21-mediated time-dependent mechanisms.
Wang Y, Liu H, Zhang R, Xiang Y, Lu J, Xia B, Peng L, Wu J
The Journal of biological chemistry 2022
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Zhao L, Jiang H, Xie J, Shen D, Yi Q, Yan J, Li C, Zheng H, Gao H
Molecular Neurobiology 2022
Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome Via B-hydroxybutyrate and Fibroblast Growth Factor 21
Kim ER, Kim SR, Cho W, Lee SG, Kim SH, Kim JH, Choi E, Kim JH, Yu JW, Lee BW, Kang ES, Cha BS, Lee MS, Cho JW, Jeon JY, Lee YH
Frontiers in immunology 2022
Hepatic hormone FGF21 and its analogues in clinical trials
Shao W, Jin T
Chronic Diseases and Translational Medicine 2022
Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease
Liao CJ, Huang PS, Chien HT, Lin TK, Yeh CT, Lin KH
Biomedicines 2022
Circulating FGF21 vs. Stress Markers in Girls during Childhood and Adolescence, and in Their Caregivers: Intriguing Inter-Relations between Overweight/Obesity, Emotions, Behavior, and the Cared-Caregiver Relationship
Christaki EV, Pervanidou P, Papassotiriou I, Mantzou A, Giannakakis G, Boschiero D, Chrousos GP
Children 2022
Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis
Puengel T, Lefere S, Hundertmark J, Kohlhepp M, Penners C, Van de Velde F, Lapauw B, Hoorens A, Devisscher L, Geerts A, Boehm S, Zhao Q, Krupinski J, Charles ED, Zinker B, Tacke F
International journal of molecular sciences 2022
Association of serum fibroblast growth factor 21 with diabetic complications and insulin dose in patients with type 1 diabetes mellitus
Taniguchi H, Nirengi S, Ishihara K, Sakane N
PloS one 2022
Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
Plummer JD, Johnson JE
Aging Cell 2022
Fibroblast growth factor 21 reverses high-fat diet-induced impairment of vascular function via the anti-oxidative pathway in ApoE knockout mice.
Huang WP, Chen CY, Lin TW, Kuo CS, Huang HL, Huang PH, Lin SJ
Journal of Cellular and Molecular Medicine 2022
Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart.
Kawakami R, Sunaga H, Iso T, Kaneko R, Koitabashi N, Obokata M, Harada T, Matsui H, Yokoyama T, Kurabayashi M
Scientific Reports 2022
Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients
Nakamura K, Isoyama N, Nakayama Y, Hiroyoshi T, Fujikawa K, Miura Y, Kurosu H, Matsuyama H, Kuro-o M
Scientific Reports 2022
Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
López-Bermudo L, Luque-Sierra A, Maya-Miles D, Gallego-Durán R, Ampuero J, Romero-Gómez M, Berná G, Martín F
Frontiers in Endocrinology 2022
Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
Srivastava H, Pozzoli M, Lau E
2022
FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
Samms RJ, Cheng CC, Fourcaudot M, Heikkinen S, Khattab A, Adams J, Cersosimo E, Triplitt C, Puckett C, Tsintzas K, Adams AC, Abdul-Ghani MA, DeFronzo RA, Norton L
American journal of physiology. Endocrinology and metabolism 2022
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention
Zhu Y, Li N, Huang M, Chen X, An YA, Li J, Zhao S, Funcke JB, Cao J, He Z, Zhu Q, Zhang Z, Wang ZV, Xu L, Williams KW, Li C, Grove K, Scherer PE
Acta pharmaceutica Sinica. B 2022
Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss
Christoffersen BØ, Sanchez\u2010Delgado G, John LM, Ryan DH, Raun K, Ravussin E
Obesity (Silver Spring, Md.) 2022
Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice
Zhang Z, Diao P, Zhang X, Nakajima T, Kimura T, Tanaka N
Biomedicines 2022
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
Ren Y, Zhao H, Yin C, Lan X, Wu L, Du X, Griffiths HR, Gao D
Frontiers in Endocrinology 2022
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z
Science Advances 2022
Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats
Tillman EJ, Brock WJ, Rolph T
British Journal of Pharmacology 2022
Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study
Buell-Acosta JD, Garces MF, Parada-Baños AJ, Angel-Muller E, Paez MC, Eslava-Schmalbach J, Escobar-Cordoba F, Caminos-Cepeda SA, Lacunza E, Castaño JP, Nogueiras R, Dieguez C, Ruiz-Parra AI, Caminos JE
Cells 2022
Sexual Dimorphism in Adipose-Hypothalamic Crosstalk and the Contribution of Aryl Hydrocarbon Receptor to Regulate Energy Homeostasis
Haque N, Tischkau SA
International journal of molecular sciences 2022
FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism
Szczepańska E, Glinicki P, Zgliczyński W, Słowińska-Srzednicka J, Jastrzębska H, Gietka-Czernel M
Frontiers in Endocrinology 2022
Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage
Kubota S, Aoyama E, Takigawa M, Nishida T
International journal of molecular sciences 2022
Heart failure in obesity: insights from proteomics in patients treated with or without weight-loss surgery.
Karason K, Girerd N, Andersson-Asssarsson J, Duarte K, Taube M, Svensson PA, Huby AC, Peltonen M, Carlsson LM, Zannad F
International Journal of Obesity 2022
The effect of different weight loss strategies to treat non-alcoholic fatty liver disease focusing on fibroblast growth factor 21
Power Guerra N, Leyens K, Müller L, Brauer D, Janowitz D, Schlick S, Pilz K, Grabe HJ, Vollmar B, Kuhla A
Frontiers in Nutrition 2022
Cellular and Molecular Regulation of Exercise-A Neuronal Perspective.
Reddy I, Yadav Y, Dey CS
Cellular and Molecular Neurobiology 2022
Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity.
Claflin KE, Sullivan AI, Naber MC, Flippo KH, Morgan DA, Neff TJ, Jensen-Cody SO, Zhu Z, Zingman LV, Rahmouni K, Potthoff MJ
Molecular Metabolism 2022
Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression
Kim HY, Yoo YH
International journal of molecular sciences 2022
E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet
Afruza R, Dhurandhar NV, Hegde V
International journal of molecular sciences 2022
Blood and Urinary Biomarkers of Antipsychotic-Induced Metabolic Syndrome
Khasanova AK, Dobrodeeva VS, Shnayder NA, Petrova MM, Pronina EA, Bochanova EN, Lareva NV, Garganeeva NP, Smirnova DA, Nasyrova RF
Metabolites 2022
Fibroblast growth factor 21 in heart failure.
Tucker W, Tucker B, Rye KA, Ong KL
Heart Failure Reviews 2022
Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases
Machado SA, Pasquarelli-do-Nascimento G, da Silva DS, Farias GR, de Oliveira Santos I, Baptista LB, Magalhães KG
Nutrition & Metabolism 2022
Nuclear Receptors in Energy Metabolism.
Walth-Hummel AA, Herzig S, Rohm M
Advances in experimental medicine and biology 2022
Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
Patel S, Haider A, Alvarez-Guaita A, Bidault G, El-Sayed Moustafa JS, Guiu-Jurado E, Tadross JA, Warner J, Harrison J, Virtue S, Scurria F, Zvetkova I, Blüher M, Small KS, O\u2019Rahilly S, Savage DB
Molecular Metabolism 2022
Beneficial Effects of Table Grape Use on Serum Levels of Omega-3 Index and Liver Function: A Randomized Controlled Clinical Trial
Notarnicola M, De Nunzio V, Lippolis T, Tutino V, Cisternino AM, Iacovazzi PA, Milella RA, Gasparro M, Negro R, Polignano M, Caruso MG
Biomedicines 2022
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression
Steinhoff JS, Wagner C, Taschler U, Wulff S, Kiefer MF, Petricek KM, Wowro SJ, Oster M, Flores RE, Yang N, Li C, Meng Y, Sommerfeld M, Weger S, Henze A, Raila J, Lass A, Schupp M
Journal of lipid research 2022
Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina
Hung WC, Yu TH, Wang CP, Hsu CC, Lu YC, Wei CT, Chung FM, Lee YJ, Wu CC, Tang WH
BMC Cardiovascular Disorders 2022
Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021
She QY, Li LJ, Liu MH, Tan RY, Zhong YW, Bao JF, Xie JD
Frontiers in pharmacology 2022
Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use
van Deuren T, Blaak EE, Canfora EE
Obesity Reviews 2022
Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner
Sideromenos S, Gundacker A, Nikou M, Oberle R, Horvath O, Stoehrmann P, Partonen T, Pollak DD
Journal of Neuroscience 2022
Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network
Mezhnina V, Ebeigbe OP, Velingkaar N, Poe A, Sandlers Y, Kondratov RV
Proceedings of the National Academy of Sciences 2022
Autocrine FGF1 signaling promotes glucose uptake in adipocytes
Nies VJ, Struik D, Liu S, Liu W, Kruit JK, Downes M, van Zutphen T, Verkade HJ, Evans RM, Jonker JW
Proceedings of the National Academy of Sciences 2022
Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
Xu L, Li D, Li H, Zhang O, Huang Y, Shao H, Wang Y, Cai S, Zhu Y, Jin S, Ding C
Nutrition & Diabetes 2022
Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis
Hou HW, Bishop CA, Huckauf J, Broer I, Klaus S, Nausch H, Buyel JF
Frontiers in Plant Science 2022
Do Sugar-Sweetened Beverages Increase Fasting FGF21 Irrespective of the Type of Added Sugar? A Secondary Exploratory Analysis of a Randomized Controlled Trial
Geidl-Flueck B, Hochuli M, Spinas GA, Gerber PA
Nutrients 2022
Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells
Yamada Y, Saito H, Araki M, Tsuchimoto Y, Muroi SI, Suzuki K, Toume K, Kim JD, Matsuzaka T, Sone H, Shimano H, Nakagawa Y
Nutrients 2022
Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers
SUI Y, CHEN J
International journal of biological sciences 2022
The potential therapeutic effect of klotho on cell viability in human colorectal adenocarcinoma HT-29 cells.
Sariboyaci AE, Uysal O, Soykan MN, Gunes S
Medical Oncology 2022
Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes.
Cui X, Feng J, Wei T, Zhang L, Lang S, Yang K, Yang J, Liu J, Sterr M, Lickert H, Wei R, Hong T
Diabetologia 2022
Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents
Gvazava IG, Karimova MV, Vasiliev AV, Vorotelyak EA
Acta Naturae 2022
Liver Brain Interactions: Focus on FGF21 a Systematic Review.
Prida E, Álvarez-Delgado S, Pérez-Lois R, Soto-Tielas M, Estany-Gestal A, Fernø J, Seoane LM, Quiñones M, Al-Massadi O
International journal of molecular sciences 2022
The New Markers of Early Obesity-Related Organ and Metabolic Abnormalities.
Ziomber-Lisiak A, Piana K, Ostachowicz B, Wróbel P, Kasprzyk P, Kaszuba-Zwoińska J, Baranowska-Chowaniec A, Juszczak K, Szczerbowska-Boruchowska M
International journal of molecular sciences 2022
The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly
Zamboni M, Mazzali G, Brunelli A, Saatchi T, Urbani S, Giani A, Rossi AP, Zoico E, Fantin F
Cells 2022
Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health
Kim E, Yoo SH, Chen Z
F1000Research 2022
Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric Type 1 and Type 2 Diabetes: A Cross-Sectional Analysis
Arking A, Sarver DC, Magge SN, Wong GW, Wolf RM
Hormone Research in Paediatrics 2022
Emerging roles of fibroblast growth factor 21 in critical disease
Yan F, Yuan L, Yang F, Wu G, Jiang X
Frontiers in Cardiovascular Medicine 2022
Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children
Akduman F, Şıklar Z, Özsu E, Doğan Ö, Kır MK, Berberoğlu M
Journal of clinical research in pediatric endocrinology 2022
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action
Chan J, Chan J, Shao L, Stawicki SS, Pham VC, Akita RW, Hafner M, Crocker L, Yu K, Koerber JT, Schaefer G, Comps-Agrar L
The Journal of biological chemistry 2022
Reactive Oxygen and Nitrogen Species (RONS) and Cytokines-Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle.
Llanos P, Palomero J
Cells 2022
Exercise-induced intertissue communication: adipose tissue and the heart
Blackwell JA, Stanford KI
Current Opinion in Physiology 2022
The potential function and clinical application of FGF21 in metabolic diseases
Chen Z, Yang L, Liu Y, Huang P, Song H, Zheng P
Frontiers in pharmacology 2022
Performance and Metabolic, Inflammatory, and Oxidative Stress-Related Parameters in Early Lactating Dairy Cows with High and Low Hepatic FGF21 Expression
Gessner DK, Sandrock LM, Most E, Koch C, Ringseis R, Eder K
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Reflections on the state of diabetes research and prospects for treatment
Accili D, Du W, Kitamoto T, Kuo T, McKimpson W, Miyachi Y, Mukhanova M, Son J, Wang L, Watanabe H
Diabetology International 2022
The Origins, Evolution, and Future of Dietary Methionine Restriction
Fang H, Stone KP, Wanders D, Forney LA, Gettys TW
Annual Review of Nutrition 2022
New developments in the biology of fibroblast growth factors
Ornitz DM, Itoh N
2022
Fibroblast growth factor 21 and bone homeostasis
Tang Y, Zhang M
Biomedical journal 2022
Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next
Jin T
2022
Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity
Molnár Á, Szentpéteri A, Lőrincz H, Seres I, Harangi M, Balogh Z, Kempler P, Paragh G, Sztanek F
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A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats
Geng L, Zhang B, Liu H, Wang S, Cai Y, Yang K, Zou Z, Jiang X, Liu Z, Li W, Wu Z, Liu X, Chu Q, Liu GH, Qu J, Zhang W
Life Medicine 2022
Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
Xu Y, Lu Y
Biochemical and biophysical research communications 2022
Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes
Shelly R Nason, Jessica P. Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H Pierre, Teayoun Kim, Jodi R Paul, Cassie L Holleman, Martin Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S Hunter, Alexei Kharitonenkov, Kirk M Habegger
JCI Insight 2021
The dynamics of human bone marrow adipose tissue in response to feeding and fasting
Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Reed, Wenxiu Zhao, Xun Zhang, Alexander Faje, Megi Resulaj, Sai P. Polineni, Tara M Holmes, Hang Lee, Elizabeth O’Donnell, Ormond MacDougald, Mark C. Horowitz, Clifford Rosen, Anne Klibanski
JCI Insight 2021
HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis
N Agarwal, D Iyer, P Saha, AR Cox, Y Xia, NS Utay, A Somasundaram, U Schubert, JE Lake, SM Hartig, A Balasubramanyam
Diabetes 2021
Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes
R Gao, Q Fu, HM Jiang, M Shen, RL Zhao, Y Qian, YQ He, KF Xu, XY Xu, H Chen, Q Zhang, T Yang
iScience 2021
Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation
F Li, J Chen, Y Liu, Z Gu, M Jiang, L Zhang, SY Chen, Z Deng, CJ McClain, W Feng
Cells 2021
Mitochondrial Regulation: Methods and Protocols
CM Palmeira, AP Rolo
2021
Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?
AD Ciaula, S Passarella, H Shanmugam, M Noviello, L Bonfrate, DQ Wang, P Portincasa
International journal of molecular sciences 2021
β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development
S Rao, X Yang, K Ohshiro, S Zaidi, Z Wang, K Shetty, X Xiang, I Hassan, T Mohammad, P Latham, B Nguyen, L Wong, H Yu, Y Al-Abed, B Mishra, M Vacca, G Guenigault, M Allison, A Vidal-Puig, J Benhammou, M Alvarez, P Pajukanta, J Pisegna, L Mishra
Science Translational Medicine 2021
Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients
L Jiang, Q Yin, M Yang, M Li, M Pan, Y Han, Z Zhao, Z Wang, L Zhu, Q Wei, Y Tu, M Gao, H Liu, X Zhang, B Liu, B Wang
Kidney Diseases 2021
Therapeutic Targets, Novel Drugs, and Delivery Systems for Diabetes associated NAFLD and Liver Fibrosis
V Kumar, X Xin, J Ma, C Tan, N Osna, RI Mahato
Advanced Drug Delivery Reviews 2021
Metabolic Changes of Hepatocytes in NAFLD
Q Lu, X Tian, H Wu, J Huang, M Li, Z Mei, L Zhou, H Xie, S Zheng
Frontiers in physiology 2021
The Saga of Endocrine FGFs
P Phan, BB Saikia, S Sonnaila, S Agrawal, Z Alraawi, TK Kumar, S Iyer
Cells 2021
Pathophysiological Implications of Imbalances in Fibroblast Growth Factor 23 in the Development of Diabetes
J Donate-Correa, E Martín-Núñez, A González-Luis, CM Ferri, D Luis-Rodríguez, VG Tagua, C Mora-Fernández, JF Navarro-González
Journal of Clinical Medicine 2021
The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits
S Epperlein, C Gebhardt, K Rohde, R Chakaroun, M Patt, I Schamarek, S Kralisch, JT Heiker, M Scholz, M Stumvoll, P Kovacs, J Breitfeld, A Tönjes
Biomedicines 2021
Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration
J Poloczek, W Kazura, E Kwaśnicka, J Gumprecht, J Jochem, D Stygar, M Chattopadhyay
Journal of Diabetes Research 2021
Skeletal Muscle and Bone – Emerging Targets of Fibroblast Growth Factor-21
H Sun, M Sherrier, H Li
Frontiers in physiology 2021
Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
K Eder, DK Gessner, R Ringseis
Journal of Animal Science and Biotechnology 2021
Advances in Biological Functions and Clinical Studies of FGF21
W Lin, T Zhang, Y Zhou, J Zheng, Z Lin
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2021
Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver
SG Kang, SE Lee, MJ Choi, JY Chang, JT Kim, BY Zhang, YE Kang, JH Lee, HS Yi, M Shong
Cells 2021
Metabolic Messengers: FGF21
KH Flippo, MJ Potthoff
Nature metabolism 2021
LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia
D Rader, E Maratos-Flier, A Nguyen, D Hom, M Ferriere, Y Li, J Kompa, M Martic, M Hinder, C Basson, D Yowe, J Diener, A Goldfine, A Bajaj, M Escalon, M Fein, A Hunt, M Kankam, M Koren, D Rader, J Wilson
The Journal of clinical endocrinology and metabolism 2021
Anti-obesity drug discovery: advances and challenges
TD Müller, M Blüher, MH Tschöp, RD DiMarchi
Nature Reviews Drug Discovery 2021
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology
B Li, SY Cai, JL Boyer
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2021
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice
YK Lee, B Diaz, M Deroose, SX Lee, S Belvedere, D Accili, RL Leibel, HV Lin
Molecular Metabolism 2021
Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus
L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv, H Li, C Wang, Q Ma, Y Li, P Li, H Du, B Zhao
Adipocyte 2021
The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair
F Khosravi, N Ahmadvand, S Bellusci, H Sauer
Frontiers in Cell and Developmental Biology 2021
The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases
J Yan, Y Nie, J Cao, M Luo, M Yan, Z Chen, B He
Frontiers in Cardiovascular Medicine 2021
FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
O Stöhr, R Tao, J Miao, KD Copps, MF White
Cell Reports 2021
The Transcriptome and Epigenome Reveal Novel Changes in Transcription Regulation During Pancreatic Rat Islet Maturation
YC Lien, XM Lu, KJ Won, PZ Wang, W Osei-Bonsu, RA Simmons
Endocrinology 2021
Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives
M Finotti, M Romano, P Auricchio, M Scopelliti, M Brizzolari, U Grossi, M Piccino, S Benvenuti, G Morana, U Cillo, G Zanus
Journal of Personalized Medicine 2021
Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity
Y Luo, X Li, J Ma, JL Abbruzzese, W Lu
Cancers 2021
FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+‐dependent manner
Q Dai, X Fan, X Meng, S Sun, Y Su, X Ling, X Chen, K Wang, X Dai, C Zhang, S Da, G Zhang, C Gu, H Chen, J He, H Hu, L Yu, X Pan, Y Tan, X Yan
Journal of Cellular and Molecular Medicine 2021
Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
SG Kang, MJ Choi, SB Jung, HK Chung, JY Chang, JT Kim, YE Kang, JH Lee, HJ Hong, SM Jun, HJ Ro, JM Suh, H Kim, J Auwerx, HS Yi, M Shong
iScience 2021
Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan
M Kobayashi, Y Nezu, R Tagawa, Y Higami
International journal of molecular sciences 2021
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective
ML Spina, PS Contreras, A Rissone, NK Meena, E Jeong, JA Martina
Frontiers in Cell and Developmental Biology 2021
Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
JD Plummer, SD Postnikoff, JK Tyler, JE Johnson
eLife 2021
Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
M Kesić, P Baković, R Stojković, J Štefulj, L Čičin-Šain
International journal of molecular sciences 2021
Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia
RM Wolf, AE Jaffe, S Rodriguez, X Lei, DC Sarver, AT Straub, GW Wong, SN Magge
American journal of physiology. Endocrinology and metabolism 2021
Skeletal endocrinology: where evolutionary advantage meets disease
N Jaschke, W Sipos, LC Hofbauer, TD Rachner, M Rauner
Bone Research 2021
Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice
Y Jiang, J Han, Y Li, Y Wu, N Liu, SX Shi, L Lin, J Yuan, S Wang, MM Ning, AS Dumont, X Wang
Translational Stroke Research 2021
The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders
J Porcuna, J Mínguez-Martínez, M Ricote
International journal of molecular sciences 2021
Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice
N Shah, MA Abdalla, H Deshmukh, T Sathyapalan
Therapeutic Advances in Endocrinology and Metabolism 2021
Obesity and Pancreatic Cancer: Insight into Mechanisms
G Eibl, E Rozengurt
Cancers 2021
CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions
Y Nakagawa, M Araki, S Han, Y Mizunoe, H Shimano
Nutrients 2021
Molecular mechanisms of dietary restriction promoting health and longevity
CL Green, DW Lamming, L Fontana
Nature Reviews Molecular Cell Biology 2021
Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff
Molecular Metabolism 2021
Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model
JH Kim, GY Lee, HJ Maeng, H Kim, JH Bae, KM Kim, S Lim
Endocrinology and Metabolism 2021
Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice
XH Liu, ZA Graham, L Harlow, J Pan, D Azulai, WA Bauman, J Yarrow, CP Cardozo
Frontiers in Endocrinology 2021
Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ
L Mazuecos, C Pintado, B Rubio, E Guisantes-Batán, A Andrés, N Gallardo
International journal of molecular sciences 2021
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1
Y Xu, KL Denning, Y Lu
Biochemical Pharmacology 2021
Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice
NJ Queen, R Bates, W Huang, R Xiao, B Appana, L Cao
Molecular Therapy — Methods & Clinical Development 2021
Effect of high-intensity circuit training on obesity indices, physical fitness, and browning factors in inactive female college students
JS Lee, ES Yoon, SY Jung, KT Yim, DY Kim
Journal of Exercise Rehabilitation 2021
FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
H Dai, W Hu, L Zhang, F Jiang, X Mao, G Yang, L Li
Cell Death and Disease 2021
FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
AI Urraza-Robledo, M Giralt, FF González-Galarza, F Villarroya, AA Pérez, PR Flores, ME Pérez, P Domingo, FC López-Márquez, YM Feng
PloS one 2021
Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis
MJ Kim, D Febbraro, S Farkona, T Gillmore, JE Son, R Regeenes, HH Chang, E Pollock-Tahiri, J Yang, YJ Park, T Sivasubramaniyam, SJ Oh, P Saraon, I Stagljar, JV Rocheleau, CC Hui, I Caniggia, Z Hao, TW Mak, A Konvalinka, M Woo
Molecular Metabolism 2021
Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
YN Kim, JH Shin, DS Kyeong, SY Cho, MY Kim, HJ Lim, MR Jimenez, IY Kim, MO Lee, YS Bae, JK Seong
Experimental & molecular medicine 2021
Regulation and Potential Biological Role of Fibroblast Growth Factor 21 in Chronic Kidney Disease
X Zhou, Y Zhang, N Wang
Frontiers in physiology 2021
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway
Y Wu, Z Ren, S Zhu, Y Wu, G Wang, H Zhang, W Chen, Z He, X Ye, Q Zhai
Acta Pharmacologica Sinica 2021
MiR-21-3p Inhibits Adipose Browning by Targeting FGFR1 and Aggravates Atrial Fibrosis in Diabetes
J Pan, H Lin, J Yu, H Zhang, J Zhang, C Wang, J Gu, AD McCarthy
Oxidative Medicine & Cellular Longevity 2021
The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression
E Makarova, A Kazantseva, A Dubinina, T Jakovleva, N Balybina, K Baranov, N Bazhan
International journal of molecular sciences 2021
A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis
Q Pan, S Lin, Y Li, L Liu, X Li, X Gao, J Yan, B Gu, X Chen, W Li, X Tang, C Chen, L Guo
EBioMedicine 2021
Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis
A Wu, B Feng, J Yu, L Yan, L Che, Y Zhuo, Y Luo, B Yu, D Wu, D Chen
Redox Biology 2021
Regulation of diurnal energy balance by mitokines
S Klaus, CI Gil, M Ost
Cellular and Molecular Life Sciences 2021
Fibroblast growth factor 21 is associated with increased serum total antioxidant capacity and oxidized lipoproteins in humans with different stages of chronic kidney disease
GS Ángel, VA Paola, MS David, PB Lucía, VZ Mauricio, NF Fernanda, MG Guadalupe, FC Ignacio, ZV María, VV Olynka, CR Ricardo, RP Rodolfo, MB E., AG Josefina, RG Berenice, PD Lizette, LC Malaquías, MG de los Ángeles, BA Victoria, EC Ángeles, LC Guadalupe, LE Angelina, GP Elizabeth, GP J., CR Daniel
Therapeutic Advances in Endocrinology and Metabolism 2021
Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease
A Ingles-Prieto, N Furthmann, SH Crossman, AM Tichy, N Hoyer, M Petersen, V Zheden, J Biebl, E Reichhart, A Gyoergy, DE Siekhaus, P Soba, KF Winklhofer, H Janovjak, B Lu
PLoS genetics 2021
Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice
NP Guerra, A Parveen, D Bühler, DL Brauer, L Müller, K Pilz, M Witt, Ä Glass, R Bajorat, D Janowitz, O Wolkenhauer, B Vollmar, A Kuhla
Nutrients 2021
The Role of Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms
M Xiao, Y Tang, S Wang, J Wang, J Wang, Y Guo, J Zhang, J Gu
Frontiers in Endocrinology 2021
Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double‐blind placebo‐controlled clinical trials
K Yokote, S Yamashita, H Arai, E Araki, M Matsushita, T Nojima, H Suganami, S Ishibashi
Cardiovascular Diabetology 2021
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19
S Ajaz, MJ McPhail, KK Singh, S Mujib, FM Trovato, S Napoli, K Agarwal
American journal of physiology. Cell physiology 2021
Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
J Sostre-Colón, K Uehara, AE Whitlock, MJ Gavin, J Ishibashi, MJ Potthoff, P Seale, PM Titchenell
Cell Reports 2021
Increased Fibroblast Growth Factor 21 (FGF21) Concentration in Early Second Trimester Amniotic Fluid and Its Association with Fetal Growth
N Vrachnis, S Argyridis, D Vrachnis, N Antonakopoulos, G Valsamakis, C Iavazzo, D Zygouris, N Salakos, A Rodolakis, N Vlahos, G Mastorakos, P Drakakis, Z Iliodromiti
Metabolites 2021
Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
J Moro, C Chaumontet, PC Even, A Blais, J Piedcoq, C Gaudichon, D Tomé, D Azzout-Marniche
Scientific Reports 2021
Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies
S Hua, Q Liu, J Li, M Fan, K Yan, D Ye
Reviews in Endocrine and Metabolic Disorders 2021
Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
A Martin, G Ecklu-Mensah, CW Ha, G Hendrick, DK Layman, J Gilbert, S Devkota
Nature Communications 2021
Fibroblast growth factor 21 (FGF21) is a sensitive marker of osteoporosis in haemodialysis patients: a cross-sectional observational study
L Zhu, M Li, Q Zha, M Yang, J Yu, M Pan, Q Yin, L Jiang, M Xia, BC Liu, B Wang
BMC Nephrology 2021
Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice
CS Krumm, X Xu, CJ Bare, CD Holman, S Kersten, LE Dow, AH Lee, DE Cohen
The Journal of biological chemistry 2021
Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
M Kozłowska, J Kortas, M Żychowska, J Antosiewicz, K Żuczek, S Perego, G Lombardi, E Ziemann
Scientific Reports 2021
Diagnostic Performance of Serum Biomarkers Fibroblast Growth Factor 21, Galectin-3 and Copeptin for Heart Failure with Preserved Ejection Fraction in a Sample of Patients with Type 2 Diabetes Mellitus
RD Ianoș, C Pop, M Iancu, R Rahaian, A Cozma, LM Procopciuc
Diagnostics 2021
Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice
H Masuda, A Sato, K Miyata, T Shizuno, A Oyamada, K Ishiwata, Y Nakagawa, T Asahara
Biology : open access journal 2021
The Mitochondrial Biomarkers FGF-21 and GDF-15 in Patients with Episodic and Chronic Migraine
P Burow, M Haselier, S Naegel, LM Scholle, C Gaul, T Kraya
Cells 2021
Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery
TB McKay, J Rhee, K Colon, K Adelsberger, I Turco, A Mueller, J Qu, O Akeju
Journal of Cardiothoracic and Vascular Anesthesia 2021
Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice
K Yano, K Yamaguchi, Y Seko, S Okishio, H Ishiba, N Tochiki, A Takahashi, S Kataoka, K Okuda, Y Liu, H Fujii, A Umemura, M Moriguchi, T Okanoue, Y Itoh
Laboratory Investigation 2021
Pathophysiology of NASH in endocrine diseases
K Gariani, FR Jornayvaz
Endocrine Connections 2021
Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
H Fang, KP Stone, LA Forney, D Wanders, TW Gettys
Frontiers in Endocrinology 2021
Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
F Hassan, A Nadeem, Z Li, M Javed, Q Liu, J Azhar, MS Rehman, K Cui, S ur Rehman
International journal of molecular sciences 2021
The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4.
Stone KP, Ghosh S, Kovalik JP, Orgeron M, Wanders D, Sims LC, Gettys TW
Scientific Reports 2021
FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway.
Yao D, He Q, Sun J, Cai L, Wei J, Cai G, Liu J, Lin Y, Wang L, Huang X
International journal of molecular medicine 2021
Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes.
Liu X, Liu L, Wang R, Jia X, Liu B, Ma N, Lu Q
Endocrine Connections 2021
Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese Ay Mice
Makarova E, Kazantseva A, Dubinina A, Denisova E, Jakovleva T, Balybina N, Bgatova N, Baranov K, Bazhan N
Cells 2021
Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects
Ying L, Wang L, Guo K, Hou Y, Li N, Wang S, Liu X, Zhao Q, Zhou J, Zhao L, Niu J, Chen C, Song L, Hou S, Kong L, Li X, Ren J, Li P, Mohammadi M, Huang Z
Nature Communications 2021
Association of serum fibroblast growth factor 21 with kidney function in a population-based Chinese cohort
Zhang R, Li Y, Zhou X, Zhang F, Li M, Zhang S, Zhang X, Wen X, Ji L
Medicine 2021
Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver
Yang R, Xu A, Kharitonenkov A
The Journal of clinical endocrinology and metabolism 2021
Plasma FGF-21 and Sclerostin Levels, Glycemia, Adiposity, and Insulin Sensitivity in Normoglycemic Black and White Adults
Umekwe N, Owei I, Stentz F, Dagogo-Jack S
Journal of the Endocrine Society 2021
Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
Nakanishi K, Ishibashi C, Ide S, Yamamoto R, Nishida M, Nagatomo I, Moriyama T, Yamauchi-Takihara K
Scientific Reports 2021
Association of Elevated Plasma FGF21 and Activated FGF21 Signaling in Visceral White Adipose Tissue and Improved Insulin Sensitivity in Gestational Diabetes Mellitus Subtype: A Case-Control Study
Wang N, Sun B, Guo H, Jing Y, Ruan Q, Wang M, Mi Y, Chen H, Song L, Cui W
Frontiers in Endocrinology 2021
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
EJ Tillman, T Rolph
Frontiers in Endocrinology 2020
Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands
M Zhao, Y Jung, Z Jiang, KJ Svensson
Frontiers in physiology 2020
FGF/FGFR signaling in health and disease
Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin, Z Ni, B Zhang, D Zhang, F Luo, H Chen, X Sun, JQ Feng, H Qi, L Chen
Signal Transduction and Targeted Therapy 2020
Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly
SI Stone, DJ Wegner, JA Wambach, FS Cole, F Urano, DM Ornitz
Journal of the Endocrine Society 2020
FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
E Henriksson, B Andersen
Frontiers in Endocrinology 2020
FGF19 and FGF21: In NASH we trust
S Talukdar, A Kharitonenkov
Molecular Metabolism 2020
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
L Geng, KS Lam, A Xu
Nature Reviews Endocrinology 2020
Effects of beta-conglycinin intake on circulating FGF21 levels and brown adipose tissue activity in Japanese young men: a single intake study and a randomized controlled trial
H Taniguchi, K Shimizu, S Wada, S Nirengi, H Kataoka, A Higashi
Journal of PHYSIOLOGICAL ANTHROPOLOGY 2020
The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial
HA Carroll, YC Chen, I Templeman, LJ James, JA Betts, WV Trim, JE Lewis
PloS one 2020
Exercise-Released Myokines in the Control of Energy Metabolism
C Laurens, A Bergouignan, C Moro
Frontiers in physiology 2020
Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis
Y Wang, C Ma, T Sun, L Ren
Journal of Physiology and Biochemistry 2020
Basic Mechanisms of Diabetic Heart Disease
RH Ritchie, ED Abel
Circulation research 2020
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
A Chait, LJ den Hartigh
Frontiers in Cardiovascular Medicine 2020
Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal
L Zhao, M Fan, L Zhao, H Yun, Y Yang, C Wang, D Qin
Journal of Cellular and Molecular Medicine 2020
Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
Y Zhao, MF Zhao, S Jiang, J Wu, J Liu, XW Yuan, D Shen, JZ Zhang, N Zhou, J He, L Fang, , B Xue, CJ Li
Nature Communications 2020
Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster
JE Lewis, C Monnier, H Marshall, M Fowler, R Green, S Cooper, A Chiotellis, J Luckett, AC Perkins, T Coskun, AC Adams, RJ Samms, FJ Ebling, K Tsintzas
Molecular Metabolism 2020
Fibroblast Growth Factor 21 Is Elevated in HIV and Associated With Interleukin-6:
AR Eckard, HY Hughes, NL Hagood, MA OʼRiordan, D Labbato, JC Kosco, SE Scott, GA McComsey
Journal of acquired immune deficiency syndromes (1999) 2020
Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)
K Kim, KH Kim
International journal of molecular sciences 2020
FGF21 and the Physiological Regulation of Macronutrient Preference
CM Hill, E Qualls-Creekmore, HR Berthoud, P Soto, S Yu, DH McDougal, H Münzberg, CD Morrison
Endocrinology 2020
The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis
H Xiao, S Kang
Frontiers in Genetics 2020
Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates
SA Murray, LS Dalbøge, K Baquero, CA Sanford, A Misquith, AJ Mercer, TH Meek, M Guldbrandt, B Andersen, P Kievit, KL Grove, B Kutlu
Scientific Reports 2020
Systemic effects of mitochondrial stress
R BarZiv, T Bolas, A Dillin
EMBO reports 2020
Weight Loss and Concomitant Adipose Autophagy in Methionine‐Restricted Obese Mice is Not Dependent on Adiponectin or FGF21
D Cooke, D Mattocks, SN Nichenametla, RP AnunciadoKoza, RA Koza, GP Ables
Obesity 2020
Circulating Diabetic Candidate Neurotrophic Factors, Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor 21, in Sleeve Gastrectomy
HH Yen, ST Hsieh, CL Chen, WS Yang, PC Lee, MT Lin, CN Chen, PJ Yang
Scientific Reports 2020
Accuracy of FGF‐21 and GDF‐15 for the diagnosis of mitochondrial disorders: A meta‐analysis
Y Lin, K Ji, X Ma, S Liu, W Li, Y Zhao, C Yan
Annals of Clinical and Translational Neurology 2020
Overexpression of fibroblast growth factor‐21 (FGF‐21) protects mesenchymal stem cells against caspase‐dependent apoptosis induced by oxidative stress and inflammation
GR Linares, Y Leng, D Maric, DM Chuang
Cell Biology International 2020
Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21
J Pan, SD Parlee, FM Brunel, P Li, W Lu, D Perez-Tilve, F Liu, B Finan, A Kharitonenkov, RD DiMarchi
2020
Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model
HJ Maeng, GY Lee, JH Bae, S Lim
International journal of molecular sciences 2020
FGF21 in obesity and cancer: New insights
W Lu, X Li, Y Luo
Cancer Letters 2020
Modulatory Effect of Myokines on Reactive Oxygen Species in Ischemia/Reperfusion
MR Szabó, M Pipicz, T Csont, C Csonka
International journal of molecular sciences 2020
N ‐acetyl‐seryl‐aspartyl‐lysyl‐proline is a valuable endogenous antifibrotic peptide for kidney fibrosis in diabetes: An update and translational aspects
K Kanasaki
Journal of Diabetes Investigation 2020
Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats
YC Lien, PZ Wang, XM Lu, RA Simmons
Cells 2020
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT –liver communication
CH Sponton, T Hosono, J Taura, MP Jedrychowski, T Yoneshiro, Q Wang, M Takahashi, Y Matsui, K Ikeda, Y Oguri, K Tajima, K Shinoda, RN Pradhan, Y Chen, Z Brown, LS Roberts, CC Ward, H Taoka, Y Yokoyama, M Watanabe, H Karasawa, DK Nomura, S Kajimura
EMBO reports 2020
Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet
K Nonogaki, T Kaji
Scientific Reports 2020
Endocrinological Features of Hartsfield Syndrome in an Adult Patient With a Novel Mutation of FGFR1
S Kobayashi, J Tanigawa, H Kondo, S Nabatame, A Maruoka, H Sho, K Tanikawa, R Inui, M Otsuki, I Shimomura, K Ozono, K Hashimoto
Journal of the Endocrine Society 2020
Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention
SM Figarska, J Rigdon, A Ganna, S Elmståhl, L Lind, CD Gardner, E Ingelsson
Scientific Reports 2020
Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia
CA Gilroy, ME Capozzi, AK Varanko, J Tong, DA D'Alessio, JE Campbell, A Chilkoti
Science Advances 2020
Semantic text mining in early drug discovery for type 2 diabetes
LK Hansson, RB Hansen, S Pletscher-Frankild, R Berzins, DH Hansen, D Madsen, SB Christensen, MR Christiansen, U Boulund, XA Wolf, SK Kjærulff, M van de Bunt, S Tulin, TS Jensen, R Wernersson, JN Jensen, I Safro
PloS one 2020
Recent advances in modulators of circadian rhythms: an update and perspective
S Huang, X Jiao, D Lu, X Pei, D Qi, Z Li
Journal of Enzyme Inhibition and Medicinal Chemistry 2020
Fibroblast Growth Factor 21 is Related to Atherosclerosis Independent of Nonalcoholic Fatty Liver Disease and Predicts Atherosclerotic Cardiovascular Events
L Wu, L Qian, L Zhang, J Zhang, J Zhou, Y Li, X Hou, Q Fang, H Li, W Jia
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2020
Dynamic folding modulation generates FGF21 variant against diabetes
L Zhu, H Zhao, J Liu, H Cai, B Wu, Z Liu, S Zhou, Q Liu, X Li, B Bao, J Liu, H Dai, J Wang
EMBO reports 2020
Klotho and fibroblast growth factors 19 and 21 serum concentrations in children and adolescents with normal body weight and obesity and their associations with metabolic parameters
A Socha-Banasiak, A Michalak, K Pacześ, Z Gaj, W Fendler, A Socha, E Głowacka, K Kapka, V Gołąbek, E Czkwianianc
BMC Pediatrics 2020
Fibroblast growth factor 21: a novel long-acting hypoglycemic drug for canine diabetes
X Jiang, S Liu, Y Wang, R Zhang, YK Opoku, Y Xie, D Li, G Ren
Naunyn-Schmiedeberg's Archives of Pharmacology 2020
FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
AM Blanco, JI Bertucci, S Unniappan
Scientific Reports 2020
Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women
M Ramanjaneya, M Bensila, I Bettahi, J Jerobin, TA Samra, MM Aye, M Alkasem, KS Siveen, T Sathyapalan, M Skarulis, SL Atkin, AB Abou-Samra
Frontiers in Endocrinology 2020
Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link
JY Ryu, HM Choi, HI Yang, KS Kim
International journal of molecular sciences 2020
Dietary Methionine Restriction Signals to the Brain Through Fibroblast Growth Factor 21 to Regulate Energy Balance and Remodeling of Adipose Tissue
LA Forney, H Fang, LC Sims, KP Stone, LY Vincik, AM Vick, AN Gibson, DH Burk, TW Gettys
Obesity 2020
Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment
JL Dorling, CK Martin, LM Redman
Ageing Research Reviews 2020
Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects
JM Cho, EH Yang, W Quan, EH Nam, HG Cheon
Scientific Reports 2020
The Suitability of FGF21 and FGF23 as New Biomarkers in Endometrial Cancer Patients
A Cymbaluk-Płoska, P Gargulińska, A Chudecka-Głaz, S Kwiatkowski, E Pius-Sadowska, B Machaliński
Diagnostics 2020
Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice
Q Liu, Y Liu, F Li, Z Gu, M Liu, T Shao, L Zhang, G Zhou, C Pan, L He, J Cai, X Zhang, S Barve, CJ McClain, Y Chen, W Feng
The Journal of Nutritional Biochemistry 2020
Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice
W Weng, T Ge, Y Wang, L He, T Liu, W Wang, Z Zheng, L Yu, C Zhang, X Lu
Diabetes & Metabolism Journal 2020
Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation
L Sun, J Yan, HJ Goh, P Govindharajulu, S Verma, N Michael, SA Sadananthan, CJ Henry, SS Velan, MK Leow
The Journal of clinical endocrinology and metabolism 2020
Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
Ludger Scheja, Joerg Heeren
Handbook of experimental pharmacology 2020
Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance.
Yang BC, Wu SY, Leung PS
Annals of translational medicine 2020
The protective effect of sulforaphane on type II diabetes induced by high-fat diet and low-dosage streptozotocin.
Tian S, Li X, Wang Y, Lu Y
Food Science & Nutrition 2020
Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants
Joung KE, Clausen D, Herdt A, Presti A, Snyder R, Peters C, Christou H, Mantzoros CS
2020
FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
CM Hill, T Laeger, M Dehner, DC Albarado, B Clarke, D Wanders, SJ Burke, JJ Collier, E Qualls-Creekmore, SM Solon-Biet, SJ Simpson, HR Berthoud, H Münzberg, CD Morrison
Cell Reports 2019
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
L Wang, M Mazagova, C Pan, S Yang, K Brandl, J Liu, SM Reilly, Y Wang, Z Miao, R Loomba, N Lu, Q Guo, J Liu, RT Yu, M Downes, RM Evans, DA Brenner, AR Saltiel, B Beutler, B Schnabl
Proceedings of the National Academy of Sciences 2019
Carbohydrate Sensing Through the Transcription Factor ChREBP
P Ortega-Prieto, C Postic
Frontiers in Genetics 2019
Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing
A Fernández, L Mazuecos, C Pintado, B Rubio, V López, AJ de Solís, M Rodríguez, A Andrés, N Gallardo
Nutrients 2019
FGF21 as Modulator of Metabolism in Health and Disease
C Tezze, V Romanello, M Sandri
Frontiers in physiology 2019
Low Bone Mineral Density in Anorexia Nervosa: Treatments and Challenges
PK Fazeli
Clinical Reviews in Bone and Mineral Metabolism 2019
Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application
D Struik, MB Dommerholt, JW Jonker
Current Opinion in Lipidology 2019
Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges
Ú Martínez-Garza, D Torres-Oteros, A Yarritu-Gallego, PF Marrero, D Haro, J Relat
International journal of molecular sciences 2019
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
JB Funcke, PE Scherer
Journal of lipid research 2019
Metabolic remodeling induced by mitokines in heart failure
J Duan, Z Chen, Y Wu, B Zhu, L Yang, C Yang
Aging 2019
Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone
KJ Phillips
Biology : open access journal 2019
The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren
Nature Reviews Endocrinology 2019
Cytokines and Abnormal Glucose and Lipid Metabolism
J Shi, J Fan, Q Su, Z Yang
Frontiers in Endocrinology 2019
Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis
M Watanabe, G Singhal, FM Fisher, TC Beck, DA Morgan, F Socciarelli, ML Mather, R Risi, J Bourke, K Rahmouni, OP McGuinness, JS Flier, E Maratos-Flier
Endocrine 2019
Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 Pathways
Y Benomar, M Taouis
Frontiers in Endocrinology 2019
The FGF metabolic axis
X Li
Frontiers of Medicine 2019
Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases
L Zhao, J Niu, H Lin, J Zhao, Y Liu, Z Song, C Xiang, X Wang, Y Yang, X Li, M Mohammadi, Z Huang
EBioMedicine 2019
Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver
CC Duwaerts, JJ Maher
CMGH Cellular and Molecular Gastroenterology and Hepatology 2019
Evaluation of a cell model expressing βKlotho for screening FGF21 analogues
X Guo, X Wang, Q Yuan, C Wu, H Gao, P Xu, M Liu, N Wang, D Li, G Ren
Cytotechnology 2019
Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension
G Cai, J Liu, M Wang, L Su, M Cai, K Huang, X Li, M Li, L Wang, X Huang
Experimental biology and medicine (Maywood, N.J.) 2019
A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21
SA Kliewer, DJ Mangelsdorf
Cell Metabolism 2019
Independent links between plasma xanthine oxidoreductase activity and levels of adipokines
M Furuhashi, M Matsumoto, T Murase, T Nakamura, Y Higashiura, M Koyama, M Tanaka, N Moniwa, H Ohnishi, S Saitoh, K Shimamoto, T Miura
Journal of Diabetes Investigation 2019
In Pursuit of a Biomarker of Weight Gain Susceptibility—Is FGF21 a Candidate?
LM Redman, E Ravussin
Diabetes 2019
Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
M Ameka, KR Markan, DA Morgan, LD BonDurant, SO Idiga, MC Naber, Z Zhu, LV Zingman, JL Grobe, K Rahmouni, MJ Potthoff
Scientific Reports 2019
Fibroblast Growth Factor 21 and Browning of White Adipose Tissue
D Cuevas-Ramos, R Mehta, CA Aguilar-Salinas
Frontiers in physiology 2019
B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15
YD Kim, SL Hwang, HJ Jeon, YH Jeon, B Nedumaran, K Kim, SE Lee
Scientific Reports 2019
Decrease of FGF19 contributes to the increase of fasting glucose in human in an insulin-independent manner
J Zhang, H Li, N Bai, Y Xu, Q Song, L Zhang, G Wu, S Chen, X Hou, C Wang, L Wei, A Xu, Q Fang, W Jia
Journal of Endocrinological Investigation 2019
Metabolic Determinants of Weight Gain in Humans: Metabolic Predictors of Weight Gain
P Piaggi
Obesity 2019
Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease
JE Mindur, FK Swirski
Arteriosclerosis, thrombosis, and vascular biology 2019
Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
CJ Pol, NM Pollak, MJ Jurczak, E Zacharia, I Karagiannides, ID Kyriazis, P Ntziachristos, DA Scerbo, BR Brown, I Aifantis, GI Shulman, IJ Goldberg, K Drosatos
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019
βklotho is essential for the anti‐endothelial mesenchymal transition effects of N ‐acetyl‐seryl‐aspartyl‐lysyl‐proline
R Gao, K Kanasaki, J Li, M Kitada, T Okazaki, D Koya
FEBS Open Bio 2019
Metabolic Targets in Nonalcoholic Fatty Liver Disease
WP Esler, KK Bence
CMGH Cellular and Molecular Gastroenterology and Hepatology 2019
FGF19 subfamily members: FGF19 and FGF21
K Dolegowska, M Marchelek-Mysliwiec, M Nowosiad-Magda, M Slawinski, B Dolegowska
Journal of Physiology and Biochemistry 2019
Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
M Zarei, E Pujol, T QuesadaLópez, F Villarroya, E Barroso, S Vázquez, J PizarroDelgado, X Palomer, M VázquezCarrera
British Journal of Pharmacology 2019
Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
M Morita, N Siddiqui, S Katsumura, C Rouya, O Larsson, T Nagashima, B Hekmatnejad, A Takahashi, H Kiyonari, M Zang, R St-Arnaud, Y Oike, V Giguère, I Topisirovic, M Okada-Hatakeyama, T Yamamoto, N Sonenberg
Proceedings of the National Academy of Sciences 2019
Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice
KR Larson, AT Chaffin, ML Goodson, Y Fang, KK Ryan
Endocrinology 2019
Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
D Flicker, Y Sancak, E Mick, O Goldberger, VK Mootha
Cell Reports 2019
Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
W Yang, L Liu, Y Wei, C Fang, F Zhou, J Chen, Q Han, M Huang, X Tan, Q Liu, Q Pan, L Zhang, X Lei, L Li
Endocrine Connections 2019
Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins
Latko, Czyrek, Porębska, Kucińska, Otlewski, Zakrzewska, Opaliński
Cells 2019
Ishige okamurae Extract Ameliorates the Hyperglycemia and Body Weight Gain of db/db Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21
YJ Seo, K Lee, S Chei, JH Song, BY Lee
Marine drugs 2019
Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes
S Westphal, T Gantert, C Kless, K Hüttinger, M Klingenspor, T Fromme
Scientific Reports 2019
Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle
CS Kim, Y Joe, HS Choi, SH Back, JW Park, HT Chung, E Roh, MS Kim, TY Ha, R Yu
Journal of Inflammation 2019
Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats
G Alemán, AL Castro, A Vigil-Martínez, I Torre-Villalvazo, A Díaz-Villaseñor, LG Noriega, I Medina-Vera, G Ordáz, N Torres, AR Tovar
Genes & Nutrition 2019
Effects of long-term feeding of rapeseed meal on skeletal muscle transcriptome, production efficiency and meat quality traits in Norwegian Landrace growing-finishing pigs
A Skugor, NP Kjos, AY Sundaram, LT Mydland, R Ånestad, AH Tauson, M Øverland, C Óvilo
PloS one 2019
Inter‐organ communication: a gatekeeper for metabolic health
J CastilloArmengol, L Fajas, IC LopezMejia
EMBO reports 2019
Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway
L Ying, N Li, Z He, X Zeng, Y Nan, J Chen, P Miao, Y Ying, W Lin, X Zhao, L Lu, M Chen, W Cen, T Guo, X Li, Z Huang, Y Wang
Cell Death and Disease 2019
Metabolic implications of organelle–mitochondria communication
I GordalizaAlaguero, C Cantó, A Zorzano
EMBO reports 2019
Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer
YE Kang, JT Kim, MA Lim, C Oh, L Liu, SN Jung, HR Won, K Lee, JW Chang, HS Yi, HJ Kim, BJ Ku, M Shong, BS Koo
Cancers 2019
Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
Q Liu, S Wang, M Wei, X Huang, Y Cheng, Y Shao, P Xia, M Zhong, S Liu, G Zhang, S Hu
Frontiers in Endocrinology 2019
Serum Fibroblast Growth Factor 21 Levels Are Positively Associated with Metabolic Syndrome in Patients with Type 2 Diabetes
RY Gao, BG Hsu, DA Wu, JS Hou, MC Chen
International Journal of Endocrinology 2019
KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese
F Ji, Y Liu, JG Hao, LP Wang, MJ Dai, GF Shen, XB Yan
Aging 2019
Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice
C Zhao, L Liu, Q Liu, F Li, L Zhang, F Zhu, T Shao, S Barve, Y Chen, X Li, CJ McClain, W Feng
Molecular Metabolism 2019
Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet
Y Luo, Y Yang, M Liu, D Wang, F Wang, Y Bi, J Ji, S Li, Y Liu, R Chen, H Huang, X Wang, AK Swidnicka-Siergiejko, T Janowitz, S Beyaz, G Wang, S Xu, AB Bialkowska, CK Luo, CL Pin, G Liang, X Lu, M Wu, KR Shroyer, RA Wolff, W Plunkett, B Ji, Z Li, E Li, X Li, VW Yang, CD Logsdon, JL Abbruzzese, W Lu
Gastroenterology 2019
Fibroblast growth factor 21 in patients with cardiac cachexia: a possible role of chronic inflammation
MR Holm, H Christensen, J Rasmussen, ML Johansen, M Schou, J Faber, C Kistorp
ESC Heart Failure 2019
Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights
WO Jonsson, NS Margolies, TG Anthony
Nutrients 2019
Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes
W Yu, H Zhu, X Chen, X Gu, X Zhang, F Shen, W Jia, C Hu
Journal of Diabetes Research 2019
The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis
PJ Antonellis, BA Droz, R Cosgrove, LS O'Farrell, T Coskun, JW Perfield, S Bauer, M Wade, TE Chouinard, JT Brozinick, AC Adams, RJ Samms
Molecular Metabolism 2019
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
MY Hochreuter, A Altıntaş, C Garde, B Emanuelli, CR Kahn, JR Zierath, S Vienberg, R Barrès
Hepatology Research 2019
Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate
Y Sasaki, S Raza-Iqbal, T Tanaka, K Murakami, M Anai, T Osawa, Y Matsumura, J Sakai, T Kodama
International journal of molecular sciences 2019
Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice
N Bazhan, T Jakovleva, N Feofanova, E Denisova, A Dubinina, N Sitnikova, E Makarova
Cells 2019
Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells
J Huang, K Wang, LA Shiflett, L Brotto, LF Bonewald, MJ Wacker, SL Dallas, M Brotto
Cell cycle (Georgetown, Tex.) 2019
Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach
S Livadas, GP Chrousos
Frontiers in Endocrinology 2019
Myokines in metabolic homeostasis and diabetes
J Eckel
Diabetologia 2019
ER-associated degradation in health and disease – from substrate to organism
A Bhattacharya, L Qi
Journal of cell science 2019
Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives
G Pennisi, C Celsa, F Spatola, M Dallio, A Federico, S Petta
International journal of environmental research and public health 2019
The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients
P Kiluk, A Baran, TW Kaminski, M Maciaszek, I Flisiak
Journal of Clinical Medicine 2019
Obesity medications in development
CJ Rebello, FL Greenway
Expert Opinion on Investigational Drugs 2019
FGF21 and glycemic control in patients with T1D
SR Rask, TK Hansen, M Bjerre
Endocrine 2019
A single combination gene therapy treats multiple age-related diseases
N Davidsohn, M Pezone, A Vernet, A Graveline, D Oliver, S Slomovic, S Punthambaker, X Sun, R Liao, JV Bonventre, GM Church
Proceedings of the National Academy of Sciences 2019
αKlotho attenuates cardiac hypertrophy and increases myocardial fibroblast growth factor 21 expression in uremic rats
PG de Albuquerque Suassuna, PM Cherem, BB de Castro, E Maquigussa, MA Cenedeze, JC Lovisi, MR Custódio, H Sanders-Pinheiro, RB de Paula
Experimental biology and medicine (Maywood, N.J.) 2019
Fibroblast growth factor 21 deficiency aggravates obesity-induced hypothalamic inflammation and impairs thermogenic response.
Mutsnaini L, Kim CS, Kim J, Joe Y, Chung HT, Choi HS, Roh E, Kim MS, Yu R
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019
Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes
Hong ES, Lim C, Choi HY, Lee YK, Ku EJ, Moon JH, Park KS, Jang HC, Choi SH
BMJ Open Diabetes Research & Care 2019
Serum Fibroblast Growth Factor 21 Levels in Patients with Hyperthyroidism and its Association with Body Fat Percentage
Bande AR, Kalra P, Dharmalingam M, Selvan C, Suryanarayana KM
Indian journal of endocrinology and metabolism 2019
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
Konrad T Sawicki, Hsiang-Chun Chang, Jason S. Shapiro, Marina Bayeva, Adam DeJesus, Brian, N Finck, Jason A. Wertheim, Perry J. Blackshear, Hossein Ardehali
JCI Insight 2018
Dietary Protein Restriction Reduces Circulating VLDL Triglyceride Levels via CREBH-APOA5 Dependent and Independent Mechanisms
jose trevino-villarreal, Justin Reynolds, Alexander Bartelt, Kent langston, Michael MacArthur, Valeri Tosti, Nicola Veronese, Beatrice Bertozzi, Lear Brace, Eylul Harputlugil, Alessandro Arduini, Pedro Mejia, Alban Longchamp, Kaspar Trocha, Gustavo Kajitani, Rose M Gathungu, Susan Bird, Arnold Bullock, Robert Figenshau, Gerald Andriole, Andrew Thompson, Joerg Heeren, C Keith Ozaki, Bruce Kristal, Luigi Fontana, James Mitchell
JCI Insight 2018
FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia
Irini Manoli, Justin R Sysol, Madeline W. Epping, Lina Li, Cindy Wang, Jennifer L. Sloan, Alexandra Pass, Jack Gagné, Yiouli P. Ktena, Lingli Li, Niraj S. Trivedi, Bazoumana Ouattara, Patricia M. Zerfas, Victoria Hoffmann, Mones Abu-Asab, Maria Tsokos, David Kleiner, Caterina Garone, Kristina Cusmano-Ozog, Gregory M. Enns, Hilary Vernon, Hans G, Andersson, Stephanie Grunewald, Abdel G. Elkahloun, Christiane L. Girard, Jurgen Schnermann, Salvatore DiMauro, Eva Andres-Mateos, Luk Vandenberghe, Randy J. Chandler, Charles P. Venditti
JCI Insight 2018
Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
H Li, G Wu, Q Fang, M Zhang, X Hui, B Sheng, L Wu, Y Bao, P Li, A Xu, W Jia
Nature Communications 2018
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia
C Wang, Z Tan, B Niu, KY Tsang, A Tai, WC Chan, RL Lo, KK Leung, NW Dung, N Itoh, MQ Zhang, D Chan, KS Cheah
eLife 2018
Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction
X Xu, C Krumm, JS So, CJ Bare, C Holman, J Gromada, DE Cohen, AH Lee
Hepatology 2018
Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism
E Tassi, KA Garman, MO Schmidt, X Ma, KW Kabbara, A Uren, Y Tomita, R Goetz, M Mohammadi, CS Wilcox, AT Riegel, M Carlstrom, A Wellstein
Scientific Reports 2018
Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
KH Kim, MS Lee
Frontiers in Endocrinology 2018
Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
K Duszka, W Wahli
International journal of molecular sciences 2018
An Integrated View of Immunometabolism
YS Lee, J Wollam, JM Olefsky
Cell 2018
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman
Physiological reviews 2018
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
LD BonDurant, MJ Potthoff
Annual Review of Nutrition 2018
Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
U Yilmaz, S Tekin, M Demir, Y Cigremis, S Sandal
The Journal of Physiological Sciences 2018
Hepatokines—a novel group of exercise factors
C Weigert, M Hoene, P Plomgaard
Pflügers Archiv - European Journal of Physiology 2018
Fibroblast growth factor 21 in chronic kidney disease
PG de Albuquerque Suassuna, RB de Paula, H Sanders-Pinheiro, OW Moe, MC Hu
Journal of Nephrology 2018
Effects of anorexia nervosa on bone metabolism
PK Fazeli, A Klibanski
Endocrine reviews 2018
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model
K Wang, X Chen, SC Ward, Y Liu, Y Ouedraogo, C Xu, AI Cederbaum, Y Lu
International Journal of Obesity 2018
FGF21 gene therapy as treatment for obesity and insulin resistance
V Jimenez, C Jambrina, E Casana, V Sacristan, S Muñoz, S Darriba, J Rodó, C Mallol, M Garcia, X León, S Marcó, A Ribera, I Elias, A Casellas, I Grass, G Elias, T Ferré, S Motas, S Franckhauser, F Mulero, M Navarro, V Haurigot, J Ruberte, F Bosch
EMBO Molecular Medicine 2018
Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner
Y Pan, B Wang, J Zheng, R Xiong, Z Fan, Y Ye, S Zhang, Q Li, F Gong, C Wu, Z Lin, X Li, X Pan
Journal of Cellular and Molecular Medicine 2018
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
B Andersen, EM Straarup, KM Heppner, DL Takahashi, V Raffaele, GA Dissen, K Lewandowski, TB Bödvarsdottir, K Raun, KL Grove, P Kievit
International Journal of Obesity 2018
Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia
K Yamanishi, S Maeda, S Kuwahara-Otani, T Hashimoto, K Ikubo, K Mukai, K Nakasho, N Gamachi, Y El-Darawish, W Li, D Okuzaki, Y Watanabe, H Yamanishi, H Okamura, H Matsunaga
Journal of Translational Medicine 2018
Curcumin and dietary polyphenol research: beyond drug discovery
T Jin
Acta Pharmacologica Sinica 2018
Effective Food Ingredients for Fatty Liver: Soy Protein β-Conglycinin and Fish Oil
T Yamazaki, D Li, R Ikaga
International journal of molecular sciences 2018
Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study: Pegbelfermin in Diabetic Patients with Obesity
ED Charles, BA Neuschwander-Tetri, JP Frias, S Kundu, Y Luo, GS Tirucherai, R Christian
Obesity 2018
The Klotho proteins in health and disease
M Kuro-o
Nature Reviews Nephrology 2018
Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis
JP Kennelly, JN van der Veen, RC Nelson, KA Leonard, R Havinga, J Buteau, F Kuipers, RL Jacobs
Journal of lipid research 2018
Chemical genetic-based phenotypic screen reveals novel regulators of gluconeogenesis in human primary hepatocytes
H Zou, Q Liu, L Meng, J Zhou, C Da, X Wu, L Jiang, J Shou, H Hua
npj Genomic Medicine 2018
Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
T Kim, S Nason, C Holleman, M Pepin, L Wilson, TF Berryhill, AR Wende, C Steele, ME Young, S Barnes, DJ Drucker, B Finan, R DiMarchi, D Perez-Tilve, M Tschöp, KM Habegger
Diabetes 2018
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
W Wei, XR An, SJ Jin, XX Li, M Xu
Scientific Reports 2018
Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice
JA Fletcher, MA Linden, RD Sheldon, GM Meers, EM Morris, A Butterfield, JW Perfield, RS Rector, JP Thyfault
Experimental Physiology 2018
Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice
AL Mayer, Y Zhang, EH Feng, CB Higgins, O Adenekan, TA Pietka, WL Beatty, BJ DeBosch
Endocrinology 2018
Skeletal muscle mitochondrial remodeling in exercise and diseases
Z Gan, T Fu, DP Kelly, RB Vega
Cell Research 2018
Fibroblast growth factor 21 induces lipolysis more efficiently than it suppresses lipogenesis in goat adipocytes
Y Zhang, L Li, Q Wang, S Zhan, L Wang, T Zhong, J Guo, H Zhang
Cytotechnology 2018
A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity
M Kitada, Y Ogura, T Suzuki, I Monno, K Kanasaki, A Watanabe, D Koya
Nutrition & Metabolism 2018
Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature
AE Libby, ES Bales, J Monks, DJ Orlicky, JL McManaman
Journal of lipid research 2018
Regulation of metabolic health by essential dietary amino acids
CL Green, DW Lamming
Mechanisms of Ageing and Development 2018
The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice
M Araki, Y Nakagawa, A Oishi, S Han, Y Wang, K Kumagai, H Ohno, Y Mizunoe, H Iwasaki, M Sekiya, T Matsuzaka, H Shimano
International journal of molecular sciences 2018
The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
YM Cho, DH Kim, KH Lee, SW Jeong, OJ Kwon
Experimental & molecular medicine 2018
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing
Y Weng, T Ishino, A Sievers, S Talukdar, JR Chabot, A Tam, W Duan, K Kerns, E Sousa, T He, A Logan, D Lee, D Li, Y Zhou, B Bernardo, A Joyce, M Kavosi, DM OHara, T Clark, J Guo, C Giragossian, M Stahl, RA Calle, R Kriz, W Somers, L Lin
Scientific Reports 2018
Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet
G Singhal, G Kumar, S Chan, ffolliott M. Fisher, Y Ma, HG Vardeh, IA Nasser, JS Flier, E Maratos-Flier
Molecular Metabolism 2018
Homeostatic sensing of dietary protein restriction: A case for FGF21
CM Hill, HR Berthoud, H Münzberg, CD Morrison
Frontiers in Neuroendocrinology 2018
LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
CT Le, G Nguyen, SY Park, DH Choi, EH Cho, P Mukhopadhyay
PloS one 2018
Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions
KR Markan
F1000Research 2018
Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus
FL Mashili, K Ramaiya, J Lutale, M Njelekela, F Francis, J Zierath, A Krook
Journal of Obesity 2018
A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling
SY Shi, YW Lu, J Richardson, X Min, J Weiszmann, WG Richards, Z Wang, Z Zhang, J Zhang, Y Li
Scientific Reports 2018
Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia
C Saint-Laurent, S Garcia, V Sarrazy, K Dumas, F Authier, S Sore, A Tran, P Gual, I Gennero, JP Salles, E Gouze, M Bader
PloS one 2018
Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa
Nature Communications 2018
FGF21 increases water intake, urine output and blood pressure in rats
T Turner, X Chen, M Zahner, A Opsahl, G DeMarco, M Boucher, B Goodwin, M Perreault, JC Dussaule
PloS one 2018
Relationship of fibroblast growth factor 21 with kidney function and albuminuria: multi-ethnic study of atherosclerosis
S Anuwatmatee, MA Allison, MG Shlipak, RL McClelland, H Kramer, S Tang, L Hou, KA Rye, KL Ong
Nephrology Dialysis Transplantation 2018
Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study
JR Choi, JY Kim, IH Park, JH Huh, KW Kim, SK Cha, KS Park, JH Sohn, JT Park, SB Koh
Yonsei Medical Journal 2018
Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action
CA Gilroy, S Roberts, A Chilkoti
Journal of Controlled Release 2018
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
A Agrawal, S Parlee, D Perez-Tilve, P Li, J Pan, PA Mroz, AM Hansen, B Andersen, B Finan, A Kharitonenkov, RD DiMarchi
Molecular Metabolism 2018
Automated assessment of steatosis in murine fatty liver
D Sethunath, S Morusu, M Tuceryan, OW Cummings, H Zhang, XM Yin, S Vanderbeck, N Chalasani, S Gawrieh, P Strnad
PloS one 2018
Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity
EF Sutton, CD Morrison, JM Stephens, LM Redman
Endocrine Research 2018
A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
TM Frayling, RN Beaumont, SE Jones, H Yaghootkar, MA Tuke, KS Ruth, F Casanova, B West, J Locke, S Sharp, Y Ji, W Thompson, J Harrison, AS Etheridge, PJ Gallins, D Jima, F Wright, Y Zhou, F Innocenti, CM Lindgren, N Grarup, A Murray, RM Freathy, MN Weedon, J Tyrrell, AR Wood
Cell Reports 2018
Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
J Villarroya, JM Gallego-Escuredo, A Delgado-Anglés, M Cairó, R Moure, MG Mateo, JC Domingo, P Domingo, M Giralt, F Villarroya
Aging Cell 2018
A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity
SY Shi, YW Lu, Z Liu, J Stevens, CM Murawsky, V Wilson, Z Hu, WG Richards, ML Michaels, J Zhang, W Yan, Y Li
The Journal of biological chemistry 2018
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
EK Kim, SH Lee, SY Lee, J Kim, JY Jhun, HS Na, SY Kim, JY Choi, CW Yang, SH Park, ML Cho
Experimental & molecular medicine 2018
Low Plasma Levels of Fibroblast Growth Factor-21 in Patients with Peripheral Artery Disease
Y Miyazaki, E Saita, Y Kishimoto, S Ibe, T Seki, K Miura, N Suzuki-Sugihara, Y Ikegami, R Ohmori, K Kondo, Y Momiyama
Journal of Atherosclerosis and Thrombosis 2018
Fibroblast growth factor 21 inhibits atherosclerosis in apoE−/− mice by ameliorating Fas-mediated apoptosis
X Yan, Z Gou, Y Li, Y Wang, J Zhu, G Xu, Q Zhang
Lipids in Health and Disease 2018
Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice
Z Yu, L Lin, Y Jiang, I Chin, X Wang, X Li, EH Lo, X Wang
Molecular Neurobiology 2018
Plasma Levels of Myonectin But Not Myostatin or Fibroblast-Derived Growth Factor 21 Are Associated with Insulin Resistance in Adult Humans without Diabetes Mellitus
FJ Toloza, JO Mantilla-Rivas, MC Pérez-Matos, ML Ricardo-Silgado, MC Morales-Alvarez, JA Pinzón-Cortés, M Pérez-Mayorga, ML Arévalo-Garcia, G Tolosa-González, CO Mendivil
Frontiers in Endocrinology 2018
Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
L Zapata, O Pich, L Serrano, FA Kondrashov, S Ossowski, MH Schaefer
Genome biology 2018
FGF-21 Elevated IL-10 Production to Correct LPS-Induced Inflammation
J Li, N Wang, MH Khoso, C Shen, M Guo, X Pang, D Li, W Wang
Inflammation 2018
Cytochrome P450S and Alcoholic Liver Disease
Y Lu, AI Cederbaum
Current pharmaceutical design 2018
The role of FGF21 in type 1 diabetes and its complications
J Zhang, W Weng, K Wang, X Lu, L Cai, J Sun
International journal of biological sciences 2018
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
M Matzinger, K Fischhuber, EH Heiss
Biotechnology Advances 2018
Control of (pre)-analytical aspects in immunoassay measurements of metabolic hormones in rodents
M Bielohuby, M Bidlingmaier, U Schwahn
Endocrine Connections 2018
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
A Lovric, M Granér, E Bjornson, M Arif, R Benfeitas, K Nyman, M Ståhlman, MO Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, MS Nieminen, N Lundbom, K Lauerma, MR Taskinen, A Mardinoglu, J Boren
Scientific Reports 2018
Characterization of fibroblast growth factor 1 in obese children and adolescents
A Wang, X Yan, C Zhang, C Du, W Long, D Zhan, X Luo
Endocrine Connections 2018
Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases
LG Leal, MA Lopes, ML Batista
Frontiers in physiology 2018
Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats
DM Sepa-Kishi, RB Ceddia
Adipocyte 2018
Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population
T Reinehr, CL Roth
Current Diabetes Reports 2018
Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis
KL Ong, RL McClelland, MA Allison, J Kokkinos, BJ Wu, PJ Barter, KA Rye
Atherosclerosis 2018
Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
A Bhattacharya, S Sun, H Wang, M Liu, Q Long, L Yin, S Kersten, K Zhang, L Qi
The EMBO Journal 2018
Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction
D Hakuno, M Kimura, S Ito, J Satoh, Y Nakashima, T Horie, Y Kuwabara, M Nishiga, Y Ide, O Baba, H Nishi, T Nakao, T Nishino, F Nakazeki, S Koyama, R Hanada, RR Randolph, J Endo, T Kimura, K Ono
Scientific Reports 2018
Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi
X Xiong, Q Wang, S Wang, J Zhang, T Liu, L Guo, Y Yu, JD Lin
Molecular Metabolism 2018
A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways
T Agnew, M Goldsworthy, C Aguilar, A Morgan, M Simon, H Hilton, C Esapa, Y Wu, H Cater, L Bentley, C Scudamore, J Poulton, KJ Morten, K Thompson, L He, SD Brown, RW Taylor, MR Bowl, RD Cox
Cell Reports 2018
Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice
Y Jiang, N Liu, Q Wang, Z Yu, L Lin, J Yuan, S Guo, BJ Ahn, XJ Wang, X Li, EH Lo, X Sun, X Wang
Stroke; a journal of cerebral circulation 2018
A study of the circulating fibroblast growth factor 21 as a novel noninvasive biomarker of hepatic injury in genotype-4 chronic hepatitis C: Egyptian patients and their response to direct-acting antiviral agents
GE Sagheer, A Ahmad, A Abd-ElFattah, Z Saad, L Hamdi
Clinical and experimental gastroenterology 2018
Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats:
YC Shi, WW Lu, YL Hou, K Fu, F Gan, SJ Cheng, SP Wang, YF Qi, JH Liu
Chinese Medical Journal 2018
Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain
JM Scarlett, K Muta, JM Brown, JM Rojas, ME Matsen, NK Acharya, A Secher, C Ingvorsen, R Jorgensen, T Høeg-Jensen, D Stefanovski, RN Bergman, F Piccinini, KJ Kaiyala, M Shiota, GJ Morton, MW Schwartz
Diabetes 2018
Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency
J Zhang, J Li, J Ma, H Wang, Y Yi
Experimental and therapeutic medicine 2018
The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis
TH Hui, RL McClelland, MA Allison, CJ Rodriguez, RA Kronmal, SR Heckbert, ED Michos, PJ Barter, KA Rye, KL Ong
Atherosclerosis 2018
FGF-21 Plays a Crucial Role in the Glucose Uptake of Activated Monocytes.
Wang N, Li JY, Zhao TT, Li SM, Shen CB, Li DS, Wang WF
Inflammation 2018
Promotion of central nervous system remyelination by peripheral FGF21
Mariko Kuroda, Rieko Muramatsu, Noriko Maedera, Yoshihisa Koyama, Machika Hamaguchi, Harutoshi Fujimura, Mari Yoshida, Morichika Konishi, Nobuyuki Itoh, Hideki Mochizuki, Toshihide Yamashita
Journal of Clinical Investigation 2017
β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota and brown adipose tissue
Emmanuel Somm, Hugues Henry, Stephen J. Bruce, Sebastien Aeby, Marta Rosikiewicz, Gerasimos Sykiotis, Mohamed Asrih, François Jornayvaz, Pierre-Damien Denechaud, Urs Albrecht, Moosa Mohammadi, andrew dwyer, James Acierno, Kristina Schoonjans, Lluis Fajas, Gilbert Greub, Nelly Pitteloud
JCI Insight 2017
Targeting nuclear receptors for the treatment of fatty liver disease
N Tanaka, T Aoyama, S Kimura, FJ Gonzalez
Pharmacology & Therapeutics 2017
Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance
LA Harris, GI Smith, BW Patterson, RS Ramaswamy, AL Okunade, SC Kelly, LC Porter, S Klein, J Yoshino, B Mittendorfer
Diabetes 2017
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
M Fisher, MS Kim, L Doridot, JC Cunniff, TS Parker, DM Levine, MK Hellerstein, LC Hudgins, E Maratos-Flier, MA Herman
Molecular Metabolism 2017
The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
KW Horst, PW Gilijamse, A Demirkiran, BA van Wagensveld, MT Ackermans, J Verheij, JA Romijn, M Nieuwdorp, E Maratos-Flier, MA Herman, MJ Serlie
Molecular Metabolism 2017
An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice
S Ghosh, LA Forney, D Wanders, KP Stone, TW Gettys, H Guillou
PloS one 2017
Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma
X Li, H Yu, J Yin, L Li, J Zhou, M Li, Q Li, H Chen, F Liu, Y Bao, J Han, W Jia
Scientific Reports 2017
Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
AM Lundsgaard, AM Fritzen, KA Sjøberg, LS Myrmel, L Madsen, JF Wojtaszewski, EA Richter, B Kiens
Molecular Metabolism 2017
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
KR Markan, MC Naber, SM Small, L Peltekian, RL Kessler, MJ Potthoff
Molecular Metabolism 2017
Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states
P Santoso, M Nakata, K Shiizaki, Z Boyang, K Parmila, Z Otgon-Uul, K Hashimoto, T Satoh, M Mori, M Kuro-o, T Yada
Scientific Reports 2017
Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism
BM Hron, CB Ebbeling, HA Feldman, DS Ludwig
Nutrition & Metabolism 2017
Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
C Wang, H Niederstrasser, PM Douglas, R Lin, J Jaramillo, Y Li, NW Olswald, A Zhou, EA McMillan, S Mendiratta, Z Wang, T Zhao, Z Lin, M Luo, G Huang, RA Brekken, BA Posner, JB MacMillan, J Gao, MA White
Nature Communications 2017
Adipose tissue autophagy and homeostasis in alcohol-induced liver injury
Y Li, WX Ding
Liver Research 2017
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, S Kaneko, T Ota
EBioMedicine 2017
Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization
L Xu, T Ota
Adipocyte 2017
Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows
A Hosseini, M Salman, Z Zhou, JK Drackley, E Trevisi, JJ Loor
Journal of Animal Science and Biotechnology 2017
The dark side of browning
KA Tamucci, M Namwanje, L Fan, L Qiang
Protein & Cell 2017
Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action
J Zhang, J Gupte, Y Gong, J Weiszmann, Y Zhang, KJ Lee, WG Richards, Y Li
EBioMedicine 2017
Fgf21 regulates T-cell development in the neonatal and juvenile thymus
Y Nakayama, Y Masuda, H Ohta, T Tanaka, M Washida, Y Nabeshima, A Miyake, N Itoh, M Konishi
Scientific Reports 2017
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
T Lan, DA Morgan, K Rahmouni, J Sonoda, X Fu, SC Burgess, WL Holland, SA Kliewer, DJ Mangelsdorf
Cell Metabolism 2017
Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
X Chen, SC Ward, AI Cederbaum, H Xiong, Y Lu
Toxicology 2017
Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese mice
Q Guo, L Xu, J Liu, H Li, H Sun, S Wu, B Zhou
Experimental biology and medicine (Maywood, N.J.) 2017
Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men
DL Chen, R Brown, C Liess, A Poljak, A Xu, J Zhang, M Trenell, A Jenkins, D Chisholm, D Samocha-Bonet, VG Macefield, JR Greenfield
Frontiers in physiology 2017
Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes
X Yuan, H Huang, Y Huang, J Wang, J Yan, L Ding, C Zhang, L Zhang
Experimental biology and medicine (Maywood, N.J.) 2017
Fibroblast growth factor 21 and its novel association with oxidative stress
MÁ Gómez-Sámano, M Grajales-Gómez, JM Zuarth-Vázquez, MF Navarro-Flores, M Martínez-Saavedra, ÓA Juárez-León, MG Morales-García, VM Enríquez-Estrada, FJ Gómez-Pérez, D Cuevas-Ramos
Redox Biology 2017
New Potential Targets of Glucagon-Like Peptide 1 Receptor Agonists in Pancreatic β-Cells and Hepatocytes
WY Lee
Endocrinology and Metabolism 2017
FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism
D Wanders, LA Forney, KP Stone, DH Burk, A Pierse, TW Gettys
Diabetes 2017
The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension
Z Huang, A Xu, BM Cheung
Current Hypertension Reports 2017
Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression
S Chen, H Li, J Zhang, S Jiang, M Zhang, Y Xu, K Dong, Y Yang, Q Fang, W Jia
BioMed Research International 2017
Fasting-induced hormonal regulation of lysosomal function
L Chen, K Wang, A Long, L Jia, Y Zhang, H Deng, Y Li, J Han, Y Wang
Cell Research 2017
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis
EP Mottillo, EM Desjardins, AM Fritzen, VZ Zou, JD Crane, JM Yabut, B Kiens, DM Erion, A Lanba, JG Granneman, S Talukdar, GR Steinberg
Molecular Metabolism 2017
The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes
M Izaguirre, MJ Gil, I Monreal, F Montecucco, G Frühbeck, V Catalán
Current Diabetes Reports 2017
Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
I Navas-Enamorado, M Bernier, G Brea-Calvo, R Cabo
Ageing Research Reviews 2017
The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice
T Goto, M Hirata, Y Aoki, M Iwase, H Takahashi, M Kim, Y Li, HF Jheng, W Nomura, N Takahashi, CS Kim, R Yu, S Seno, H Matsuda, M Aizawa-Abe, K Ebihara, N Itoh, T Kawada
The Journal of biological chemistry 2017
Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease
M Kohara, T Masuda, K Shiizaki, T Akimoto, Y Watanabe, S Honma, C Sekiguchi, Y Miyazawa, E Kusano, Y Kanda, Y Asano, M Kuro-o, D Nagata, T Shimosawa
PloS one 2017
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production
C Hine, HJ Kim, Y Zhu, E Harputlugil, A Longchamp, MS Matos, P Ramadoss, K Bauerle, L Brace, JM Asara, CK Ozaki, S Cheng, S Singha, KH Ahn, A Kimmelman, FM Fisher, P Pissios, DJ Withers, C Selman, R Wang, K Yen, VD Longo, P Cohen, A Bartke, JJ Kopchick, R Miller, AN Hollenberg, JR Mitchell
Cell Metabolism 2017
Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster
JE Lewis, RJ Samms, S Cooper, JC Luckett, AC Perkins, AC Adams, K Tsintzas, FJ Ebling
Scientific Reports 2017
Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution
A Maida, JS Chan, KA Sjøberg, A Zota, D Schmoll, B Kiens, S Herzig, AJ Rose
Molecular Metabolism 2017
Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
L Zhao, H Wang, J Xie, Z Chen, X Li, J Niu
BMC Biotechnology 2017
Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
KH Kwok, KS Lam
Endocrinology and Metabolism 2017
Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes
R Kruse, SG Vienberg, BF Vind, B Andersen, K Højlund
Diabetologia 2017
Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
BN Desai, G Singhal, M Watanabe, D Stevanovic, T Lundasen, M Fisher, ML Mather, HG Vardeh, N Douris, AC Adams, IA Nasser, GA FitzGerald, JS Flier, C Skarke, E Maratos-Flier
Molecular Metabolism 2017
Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice
JE Lewis, RJ Samms, S Cooper, JC Luckett, AC Perkins, JD Dunbar, DP Smith, PJ Emmerson, AC Adams, FJ Ebling, K Tsintzas
Endocrinology 2017
Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women
Y Wang, WP Koh, JM Yuan, A Pan
Nutrition & Metabolism 2017
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?
PM Mutie, GN Giordano, PW Franks
BMC Medicine 2017
Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability
Z Huang, Y Tan, J Gu, Y Liu, L Song, J Niu, L Zhao, L Srinivasan, Q Lin, J Deng, Y Li, DJ Conklin, TA Neubert, L Cai, X Li, M Mohammadi
Cell Reports 2017
Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit
X Liu, Y Wang, S Zhao, X Li
BioMed Research International 2017
Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
CM Hill, T Laeger, DC Albarado, DH McDougal, HR Berthoud, H Münzberg, CD Morrison
Scientific Reports 2017
FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
T Laeger, C Baumeier, I Wilhelmi, J Würfel, A Kamitz, A Schürmann
Diabetologia 2017
Mitochondrial diseases: the contribution of organelle stress responses to pathology
A Suomalainen, BJ Battersby
Nature Reviews Molecular Cell Biology 2017
Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based Therapies?
F Fatima, M Nawaz
Frontiers in physiology 2017
Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues
X Lin, YB Liu, H Hu
Biomedical Reports 2017
Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
JW Porter, JL Rowles, JA Fletcher, TM Zidon, NC Winn, LT McCabe, YM Park, JW Perfield, JP Thyfault, RS Rector, J Padilla, VJ Vieira-Potter
Journal of Endocrinology 2017
Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor
F Lizcano, D Vargas, Á Gómez, A Torrado
Stem Cells International 2017
Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation
LR Braun, MN Feldpausch, N Czerwonka, M Torriani, SK Grinspoon, TL Stanley
Growth Hormone & IGF Research 2017
Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
S Olivares, AS Henkel
Molecular Metabolism 2017
Fibroblast growth factor 21: a regulator of metabolic disease and health span
T Xie, PS Leung
American journal of physiology. Endocrinology and metabolism 2017
Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling pathway
P Liang, L Zhong, L Gong, J Wang, Y Zhu, W Liu, J Yang
International journal of molecular medicine 2017
LPS infusion suppresses serum FGF21 levels in healthy adult volunteers
ES Lauritzen, N Rittig, E Bach, N Møller, M Bjerre
Endocrine Connections 2017
Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood
SH Chen, PM Chao, JA Villena
PloS one 2017
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
M Dong, J Lin, W Lim, W Jin, HJ Lee
Frontiers of Medicine 2017
Serum FGF21 Levels in Obese Korean Children and Adolescents
J Baek, HK Nam, YJ Rhie, KH Lee
Journal of Obesity & Metabolic Syndrome 2017
Muscle-Adipose Tissue Cross Talk
KI Stanford, LJ Goodyear
Cold Spring Harbor Perspectives in Medicine 2017
Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein
AN Nguyen, JA Song, MT Nguyen, BH Do, GG Kwon, SS Park, J Yoo, J Jang, J Jin, MJ Osborn, YJ Jang, TT Vu, HB Oh, H Choe
Scientific Reports 2017
How does obesity lead to insulin resistance?
CH Choi, P Cohen
eLife 2017
Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response
LA Forney, KP Stone, D Wanders, TW Gettys
Frontiers in Neuroendocrinology 2017
Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017;26:204-9)
JH Kim
Journal of Obesity & Metabolic Syndrome 2017
Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21: Berberine regulates hepatic steatosis and energy metabolism
Y Sun, M Xia, H Yan, Y Han, F Zhang, Z Hu, A Cui, F Ma, Z Liu, Q Gong, X Chen, J Gao, H Bian, Y Tan, Y Li, X Gao
British Journal of Pharmacology 2017
New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases
S Win, TA Than, J Zhang, C Oo, RW Min, N Kaplowitz
Hepatology 2017
Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism
A Patton, FH Khan, R Kohli
Digestive Diseases 2017
Therapeutic effects of fibroblast growth factor‑21 against atherosclerosis via the NF‑κB pathway
Y Zhang, Z Liu, M Zhou, C Liu
Molecular medicine reports 2017
Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight
S Ballestri, F Nascimbeni, D Romagnoli, E Baldelli, G Targher, A Lonardo
International journal of molecular sciences 2016
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk
JH Stern, JM Rutkowski, PE Scherer
Cell Metabolism 2016
Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice
P Ziros, Z Zagoriti, G Lagoumintzis, V Kyriazopoulou, RP Iskrenova, EI Habeos, GP Sykiotis, DV Chartoumpekis, IG Habeos, K Pantopoulos
PloS one 2016
Fibroblast growth factors, old kids on the new block
X Li, C Wang, J Xiao, WL McKeehan, F Wang
Seminars in Cell & Developmental Biology 2016
The ever-expanding myokinome: discovery challenges and therapeutic implications
M Whitham, MA Febbraio
Nature Reviews Drug Discovery 2016
CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
JG Park, X Xu, S Cho, KY Hur, MS Lee, S Kersten, AH Lee
Scientific Reports 2016
Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
L Jin, Z Lin, A Xu
Diabetes & Metabolism Journal 2016
Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
B Vandanmagsar, JD Warfel, SE Wicks, S Ghosh, JM Salbaum, D Burk, OS Dubuisson, TM Mendoza, J Zhang, RC Noland, RL Mynatt
Cell Reports 2016
Fibroblast Growth Factor Signaling in Metabolic Regulation
VJ Nies, G Sancar, W Liu, T Zutphen, D Struik, RT Yu, AR Atkins, RM Evans, JW Jonker, MR Downes
Frontiers in Endocrinology 2016
KLOTHO, FGF21 AND FGF23: NOVEL PATHWAYS TO MUSCULOSKELETAL HEALTH?
B. BARTALI, R.D. SEMBA, A.B. ARAUJO
The Journal of frailty & aging 2016
Genetic insights into the mechanisms of Fgf signaling
JR Brewer, P Mazot, P Soriano
Genes & development 2016
Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents: FGF21 Rise Post-VSG Corresponds to Weight Loss
FH Khan, L Shaw, W Zhang, RM Gonzalez, S Mowery, M Oehrle, X Zhao, T Jenkins, KD Setchell, TH Inge, R Kohli
Obesity 2016
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
N Kamimura, H Ichimiya, K Iuchi, S Ohta
npj Aging and Mechanisms of Disease 2016
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
MA Herman, VT Samuel
Trends in Endocrinology & Metabolism 2016
The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
YS Jung, JM Lee, DK Kim, YS Lee, KS Kim, YH Kim, J Kim, MS Lee, IK Lee, SH Kim, SJ Cho, WI Jeong, CH Lee, RA Harris, HS Choi, JM Vanacker
PloS one 2016
Fibroblast growth factor 21 has no direct role in regulating fertility in female mice
G Singhal, N Douris, AJ Fish, X Zhang, AC Adams, JS Flier, P Pissios, E Maratos-Flier
Molecular Metabolism 2016
Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 ( Nrf2 )
K Schneider, J Valdez, J Nguyen, M Vawter, B Galke, TW Kurtz, JY Chan
The Journal of biological chemistry 2016
Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
JY Jeon, SE Choi, ES Ha, TH Kim, JG Jung, SJ Han, HJ Kim, DJ Kim, Y Kang, KW Lee
Endocrine 2016
A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis
S Chun, T Bamba, T Suyama, T Ishijima, E Fukusaki, K Abe, Y Nakai, P Aspichueta
PloS one 2016
Brown and Beige Adipose Tissue
A Mulya, JP Kirwan
Endocrinology and metabolism clinics of North America 2016
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
YH Youm, TL Horvath, DJ Mangelsdorf, SA Kliewer, VD Dixit
Proceedings of the National Academy of Sciences 2016
Adipokine Pattern After Bariatric Surgery: Beyond the Weight Loss
GF Adami, N Scopinaro, R Cordera
Obesity Surgery 2016
Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors
JD Schumacher, GL Guo
BioMed Research International 2016
BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity
S Kim, S Choe, DK Lee
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016
Association of metabolic syndrome with serum fibroblast growth factor 21 in kidney transplanted patients
L Bagheri, M Hami, MJ Mojahedi, MG Sabbagh, H Ayatollahi
Journal of Renal Injury Prevention 2016
FGF21 Is Associated with Acanthosis Nigricans in Obese Patients
Y Huang, J Yang, Y Li, J Chen, K Song, X Wang, L Bu, X Cheng, J Wang, S Qu
International Journal of Endocrinology 2016
iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy
L Lynch, AE Hogan, D Duquette, C Lester, A Banks, K LeClair, DE Cohen, A Ghosh, B Lu, M Corrigan, D Stevanovic, E Maratos-Flier, DJ Drucker, D OShea, M Brenner
Cell Metabolism 2016
Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats
N Charoenphandhu, P Suntornsaratoon, N Krishnamra, P Sa-nguanmoo, P Tanajak, X Wang, G Liang, X Li, C Jiang, N Chattipakorn, S Chattipakorn
Journal of Bone and Mineral Metabolism 2016
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
D Guan, L Zhao, D Chen, B Yu, J Yu
Journal of Translational Medicine 2016
The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
PE Scherer
Diabetes 2016
A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity
M Kitada, Y Ogura, T Suzuki, S Sen, SM Lee, K Kanasaki, S Kume, D Koya
Diabetologia 2016
Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Y Liu, C Zhao, J Xiao, L Liu, M Zhang, C Wang, G Wu, MH Zheng, LM Xu, YP Chen, M Mohammadi, SY Chen, M Cave, C McClain, X Li, W Feng
Scientific Reports 2016
Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21
EK Kim, SH Lee, JY Jhun, JK Byun, JH Jeong, SY Lee, JK Kim, JY Choi, ML Cho
Mediators of Inflammation 2016
Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction
D Wanders, KP Stone, LA Forney, CC Cortez, KN Dille, J Simon, M Xu, EC Hotard, IA Nikonorova, AP Pettit, TG Anthony, TW Gettys
Diabetes 2016
Implication of hepatokines in metabolic disorders and cardiovascular diseases
TW Jung, HJ Yoo, KM Choi
BBA Clinical 2016
Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting
PJ Antonellis, MP Hayes, AC Adams
Frontiers in Endocrinology 2016
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
AY Minard, SX Tan, P Yang, DJ Fazakerley, W Domanova, BL Parker, SJ Humphrey, R Jothi, J Stöckli, DE James
Cell Reports 2016
FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
S Zhu, Y Wu, X Ye, L Ma, J Qi, D Yu, Y Wei, G Lin, G Ren, D Li
Molecular and Cellular Biochemistry 2016
Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
P Cheng, F Zhang, L Yu, X Lin, L He, X Li, X Lu, X Yan, Y Tan, C Zhang
Journal of Diabetes Research 2016
FGF-21: promising biomarker for detecting ketosis in dairy cows
C Xu, Q Xu, Y Chen, W Yang, C Xia, H Yu, K Zhu, T Shen, Z Zhang
Veterinary Research Communications 2016
Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity: Effects of FGF21 via genetic fusion to PsTag
J Yin, L Bao, H Tian, Q Wang, X Gao, W Yao
British Journal of Pharmacology 2016
Potential roles of fibroblast growth factor 21 in the brain
P Sa-nguanmoo, N Chattipakorn, SC Chattipakorn
Metabolic Brain Disease 2016
Fibroblast activation protein (FAP) as a novel metabolic target
MA Sánchez-Garrido, KM Habegger, C Clemmensen, C Holleman, TD Müller, D Perez-Tilve, P Li, AS Agrawal, B Finan, DJ Drucker, MH Tschöp, RD DiMarchi, A Kharitonenkov
Molecular Metabolism 2016
Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice
CD Morrison, Z Hao, MB Mumphrey, RL Townsend, H Münzberg, J Ye, HR Berthoud
Molecular Metabolism 2016
A High-Throughput Targeted Proteomic Approach for Comprehensive Profiling of Methylglyoxal-Induced Perturbations of the Human Kinome
W Miao, Y Xiao, L Guo, X Jiang, M Huang, Y Wang
Analytical Chemistry 2016
Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation
D Ye, H Li, Y Wang, W Jia, J Zhou, J Fan, K Man, C Lo, C Wong, Y Wang, KS Lam, A Xu
Scientific Reports 2016
PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
WC Thompson, Y Zhou, S Talukdar, CJ Musante
Journal of Pharmacokinetics and Pharmacodynamics 2016
Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction
RH Chou, PH Huang, CY Hsu, CC Chang, HB Leu, CC Huang, JW Chen, SJ Lin
Scientific Reports 2016
Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice: Hepatology, Vol. XX, No. X, 2016 Gong et al
Q Gong, Z Hu, F Zhang, A Cui, X Chen, H Jiang, J Gao, X Chen, Y Han, Q Liang, D Ye, L Shi, YE Chin, Y Wang, H Xiao, F Guo, Y Liu, M Zang, A Xu, Y Li
Hepatology 2016
The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress
S Sekine, A Yao, K Hattori, S Sugawara, I Naguro, M Koike, Y Uchiyama, K Takeda, H Ichijo
EBioMedicine 2016
miR-149 controls non-alcoholic fatty liver by targeting FGF-21
J Xiao, D Lv, Y Zhao, X Chen, M Song, J Liu, Y Bei, F Wang, W Yang, C Yang
Journal of Cellular and Molecular Medicine 2016
Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer
K ME, M JN
Journal of Molecular Biomarkers & Diagnosis 2016
Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation
Y Tanimura, W Aoi, Y Takanami, Y Kawai, K Mizushima, Y Naito, T Yoshikawa
Physiological Reports 2016
Canine Fibroblast Growth Factor 21 Ameliorates Hyperglycemia Associated with Inhibiting Hepatic Gluconeogenesis and Improving Pancreatic Beta-Cell Survival in Diabetic Mice and Dogs
P Xu, Y Zhang, X Jiang, J Li, L Song, MH Khoso, Y Liu, Q Wu, G Ren, D Li, GF Browning
PloS one 2016
The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling
J Jager, F Wang, B Fang, HW Lim, LC Peed, DJ Steger, KJ Won, A Kharitonenkov, AC Adams, MA Lazar
The Journal of biological chemistry 2016
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
AL Coppage, KR Heard, MT DiMare, Y Liu, W Wu, JH Lai, WW Bachovchin, M Alemany
PloS one 2016
White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice
H Song, Z Zheng, J Wu, J Lai, Q Chu, X Zheng, J Peterson
PloS one 2016
Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet
L Hao, KH Huang, K Ito, S Sae-tan, JD Lambert, AC Ross
The Journal of nutrition 2016
Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis
VK Shenoy, KM Beaver, M Fisher, G Singhal, JR Dushay, E Maratos-Flier, SN Flier, J Sastre
PloS one 2016
Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
HU Lee, ZE McPherson, B Tan, A Korecka, S Pettersson
Journal of Molecular Medicine 2016
Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKAy mice
K Nonogaki, T Kaji, T Yamazaki, M Murakami
Nutrition and Diabetes 2016
Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss
A Gavrieli, CS Mantzoros
Endocrinology and Metabolism 2016
mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold
SM Labbé, M Mouchiroud, A Caron, B Secco, E Freinkman, G Lamoureux, Y Gélinas, R Lecomte, Y Bossé, P Chimin, WT Festuccia, D Richard, M Laplante
Scientific Reports 2016
Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations
M Nalbandian, M Takeda
Biology : open access journal 2016
Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation
X Lin, L Zhao, S Tang, Q Zhou, Q Lin, X Li, H Zheng, H Gao
Scientific Reports 2016
Anti-human fibroblast growth factor-21 monoclonal antibody preparation, characterization and analysis of in vitro bioactivity
L Ding, Z Hao, Q Yuan, P Xu, Y Yu, D Li
Experimental and therapeutic medicine 2016
Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding
C Loyd, IJ Magrisso, M Haas, S Balusu, R Krishna, N Itoh, DA Sandoval, D Perez-Tilve, S Obici, KM Habegger
Journal of applied physiology 2016
Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?
S Benedini, L Luzi
Journal of Translational Internal Medicine 2016
Serum Levels of Fibroblast Growth Factor 21 in Type 2 Diabetic Patient
Y Panahi
ACTA ENDOCRINOL-BUCH 2016
rowth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus
Iwona BS
Current neuropharmacology 2016
FGF21 and the late adaptive response to starvation in humans
Pouneh Fazeli, Mingyue Lun, Soo Kim, Miriam Bredella, Spenser Wright, Yang Zhang, Hang Lee, Ciprian Catana, Anne Klibanski, Parth Patwari, Matthew Steinhauser
Journal of Clinical Investigation 2015
Fibroblast growth factor 21 in breast milk controls neonatal intestine function
A Gavaldà-Navarro, E Hondares, M Giralt, T Mampel, R Iglesias, F Villarroya
Scientific Reports 2015
Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
JS Hansen, JO Clemmesen, NH Secher, M Hoene, A Drescher, C Weigert, BK Pedersen, P Plomgaard
Molecular Metabolism 2015
Fructose ingestion acutely stimulates circulating FGF21 levels in humans
JR Dushay, E Toschi, EK Mitten, FM Fisher, MA Herman, E Maratos-Flier
Molecular Metabolism 2015
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
N Tanaka, S Takahashi, Y Zhang, KW Krausz, PB Smith, AD Patterson, FJ Gonzalez
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015
Transcriptional control and hormonal response of thermogenic fat
MP Emont, H Yu, J Wu
Journal of Endocrinology 2015
Molecular Basis of Klotho: From Gene to Function in Aging
Y Xu, Z Sun
Endocrine reviews 2015
Metabolic Control
S Herzig
2015
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
S Schnyder, C Handschin
Bone 2015
Non-sympathetic control of brown adipose tissue
R Cereijo, J Villarroya, F Villarroya
International Journal of Obesity Supplements 2015
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
KR Markan, MJ Potthoff
Seminars in Cell & Developmental Biology 2015
Molecular mechanisms of fatty liver in obesity
L Gan, W Xiang, B Xie, L Yu
Frontiers of Medicine 2015
Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
Z Lin, X Pan, F Wu, D Ye, Y Zhang, Y Wang, L Jin, Q Lian, Y Huang, H Ding, C Triggle, K Wang, X Li, A Xu
Circulation 2015
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
C Degirolamo, C Sabbà, A Moschetta
Nature Reviews Drug Discovery 2015
Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy
N Itoh, H Ohta, M Konishi
Frontiers in Endocrinology 2015
Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
EM Domouzoglou, KK Naka, AP Vlahos, MI Papafaklis, LK Michalis, A Tsatsoulis, E Maratos-Flier
American journal of physiology. Heart and circulatory physiology 2015
Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21: STEATOHEPATITIS/METABOLIC LIVER DISEASE
P Lu, J Yan, K Liu, WG Garbacz, P Wang, M Xu, X Ma, W Xie
Hepatology 2015
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
BM Owen, DJ Mangelsdorf, SA Kliewer
Trends in Endocrinology & Metabolism 2015
Nutritionally-Induced Catch-Up Growth
G Gat-Yablonski, M Phillip
Nutrients 2015
UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity
D Wanders, DH Burk, CC Cortez, NT Van, KP Stone, M Baker, T Mendoza, RL Mynatt, TW Gettys
The FASEB Journal 2015
Dietary Methionine Restriction in Mice Elicits an Adaptive Cardiovascular Response to Hyperhomocysteinemia
GP Ables, A Ouattara, TG Hampton, D Cooke, F Perodin, I Augie, DS Orentreich
Scientific Reports 2015
Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice
X Ye, J Qi, G Ren, P Xu, Y Wu, S Zhu, D Yu, S Li, Q Wu, RL Muhi, D Li
Endocrine 2015
Circulating FGF19 and FGF21 surge in early infancy from infra- to supra-adult concentrations
D Sánchez-Infantes, JM Gallego-Escuredo, M Díaz, G Aragonés, G Sebastiani, A López-Bermejo, F Zegher, P Domingo, F Villarroya, L Ibáñez
International Journal of Obesity 2015
Bariatric Surgery: Prevalence, Predictors, and Mechanisms of Diabetes Remission
G Argyropoulos
Current Diabetes Reports 2015
Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
Y Yu, F Bai, Y Liu, Y Yang, Q Yuan, D Zou, S Qu, G Tian, L Song, T Zhang, S Li, YY Liu, W Wang, G Ren, D Li
Molecular and Cellular Biochemistry 2015
Protein-dependent regulation of feeding and metabolism
CD Morrison, T Laeger
Trends in Endocrinology & Metabolism 2015
Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice
M Gao, C Zhang, Y Ma, D Liu
The AAPS Journal 2015
Placental fibroblast growth factor 21 is not altered in late-onset preeclampsia
MD Nitert, K Scholz-Romero, MH Kubala, HD McIntyre, LK Callaway, HL Barrett
Reproductive Biology and Endocrinology 2015
Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients
X Zhang, Y Hu, H Zeng, L Li, J Zhao, J Zhao, F Liu, Y Bao, W Jia
Cardiovascular Diabetology 2015
Metabolism: Exercise remodels subcutaneous fat tissue and improves metabolism
H Wallberg-Henriksson, JR Zierath
Nature Reviews Endocrinology 2015
Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging
JL Schneider, J Villarroya, A Diaz-Carretero, B Patel, AM Urbanska, MM Thi, F Villarroya, L Santambrogio, AM Cuervo
Aging Cell 2015
Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
Y Jiang, AJ Rose, TP Sijmonsma, A Bröer, A Pfenninger, S Herzig, D Schmoll, S Bröer
Molecular Metabolism 2015
Induction of Peroxisomes by Butyrate-Producing Probiotics
H Weng, K Endo, J Li, N Kito, N Iwai, JM Lobaccaro
PloS one 2015
Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice
Y Weng, JR Chabot, B Bernardo, Q Yan, Y Zhu, MB Brenner, C Vage, A Logan, R Calle, S Talukdar, GW Wong
PloS one 2015
Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice
WY So, Q Cheng, A Xu, KS Lam, PS Leung
Cell Death and Disease 2015
FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
X Yan, J Chen, C Zhang, S Zhou, Z Zhang, J Chen, W Feng, X Li, Y Tan
Journal of Cellular and Molecular Medicine 2015
Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa
PK Fazeli, AT Faje, EJ Cross, H Lee, CJ Rosen, ML Bouxsein, A Klibanski
Bone 2015
Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes
WJ Kim, SS Kim, HC Lee, SH Song, MJ Bae, YS Yi, YK Jeon, BH Kim, YK Kim, IJ Kim
Journal of Korean Medical Science 2015
Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes
L Berti, M Irmler, M Zdichavsky, T Meile, A Böhm, N Stefan, A Fritsche, J Beckers, A Königsrainer, HU Häring, MH de Angelis, H Staiger
Molecular Metabolism 2015
Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals
LJ Hanks, OM Gutiérrez, MM Bamman, A Ashraf, KL McCormick, K Casazza
Journal of Clinical & Translational Endocrinology 2015
Genetic disruption of uncoupling protein 1 (UCP1) in mice renders brown adipose tissue a significant source of FGF21 secretion
S Keipert, M Kutschke, D Lamp, L Brachthäuser, F Neff, CW Meyer, R Oelkrug, A Kharitonenkov, M Jastroch
Molecular Metabolism 2015
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice
P Xu, Y Zhang, W Wang, Q Yuan, Z Liu, LM Rasoul, Q Wu, M Liu, X Ye, D Li, G Ren
Digestive Diseases and Sciences 2015
Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice
RK Boparai, O Arum, JG Miquet, MM Masternak, A Bartke, RK Khardori
International Journal of Endocrinology 2015
Serum FGF21 levels are associated with brown adipose tissue activity in humans
MJ Hanssen, E Broeders, RJ Samms, MJ Vosselman, AA van der Lans, CC Cheng, AC Adams, WD van Lichtenbelt, P Schrauwen
Scientific Reports 2015
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy
M Liu, Q Pan, Y Chen, X Yang, B Zhao, L Jia, Y Zhu, B Zhang, X Gao, X Li, J Han, Y Duan
Scientific Reports 2015
FGF21, energy expenditure and weight loss – How much brown fat do you need?
L Straub, C Wolfrum
Molecular Metabolism 2015
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
N Douris, DM Stevanovic, M Fisher, TI Cisu, MJ Chee, NL Nguyen, E Zarebidaki, AC Adams, A Kharitonenkov, JS Flier, TJ Bartness, E Maratos-Flier
Endocrinology 2015
Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
X Yan, J Chen, C Zhang, J Zeng, S Zhou, Z Zhang, X Lu, J Chen, W Feng, X Li, Y Tan
Cardiovascular Diabetology 2015
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
K Stemmer, F Zani, KM Habegger, C Neff, P Kotzbeck, M Bauer, S Yalamanchilli, A Azad, M Lehti, PJ Martins, TD Müller, PT Pfluger, RJ Seeley
Diabetologia 2015
Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
C Zhang, Z Huang, J Gu, X Yan, X Lu, S Zhou, S Wang, M Shao, F Zhang, P Cheng, W Feng, Y Tan, X Li
Diabetologia 2015
Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21
LA Harris, JR Skinner, TM Shew, TA Pietka, NA Abumrad, NE Wolins
Diabetes 2015
Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes
Y Xiao, L Liu, A Xu, P Zhou, Z Long, Y Tu, X Chen, W Tang, G Huang, Z Zhou
Cardiovascular Diabetology 2015
Relationship of fibroblast growth factor 21 with baseline and new on-study microvascular disease in the Fenofibrate Intervention and Event Lowering in Diabetes study
KL Ong, AS Januszewski, R O’Connell, L Buizen, AJ Jenkins, A Xu, DR Sullivan, PJ Barter, RS Scott, MR Taskinen, KA Rye, AC Keech
Diabetologia 2015
FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
B Bernardo, M Lu, G Bandyopadhyay, P Li, Y Zhou, J Huang, N Levin, EM Tomas, RA Calle, DM Erion, TP Rolph, M Brenner, S Talukdar
Scientific Reports 2015
Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study: Pharmacokinetics and pharmacodynamics of a novel long-acting FGF21 mimetic
JQ Dong, M Rossulek, VR Somayaji, D Baltrukonis, Y Liang, K Hudson, M Hernandez-Illas, RA Calle
British Journal of Clinical Pharmacology 2015
Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
M Shao, L Yu, F Zhang, X Lu, X Li, P Cheng, X Lin, L He, S Jin, Y Tan, H Yang, C Zhang, L Cai
American journal of physiology. Endocrinology and metabolism 2015
Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration
L Wang, T Ishihara, Y Ibayashi, K Tatsushima, D Setoyama, Y Hanada, Y Takeichi, S Sakamoto, S Yokota, K Mihara, D Kang, N Ishihara, R Takayanagi, M Nomura
Diabetologia 2015
FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice
C Zhao, Y Liu, J Xiao, L Liu, S Chen, M Mohammadi, CJ McClain, X Li, W Feng
Journal of lipid research 2015
The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review
AJ Cole, LM Teigen, C Jahansouz, CP Earthman, SD Sibley
Current Obesity Reports 2015
Novel Mediators of Adipose Tissue and Muscle Crosstalk
I Indrakusuma, H Sell, J Eckel
Current Obesity Reports 2015
FGF21 and Cardiac Physiopathology
A Planavila, I Redondo-Angulo, F Villarroya
Frontiers in Endocrinology 2015
Metabolic Effects of FGF-21: Thermoregulation and Beyond
Bin Ni, Jared S Farrar, Janina A Vaitkus, Francesco S Celi
Frontiers in Endocrinology 2015
Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD
Takeshi Inagaki
Frontiers in Endocrinology 2015
Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations
T Ebert, S Kralisch, U Wurst, M Scholz, M Stumvoll, P Kovacs, M Fasshauer, A Tönjes
International Journal of Obesity 2015
Minireview: Roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases
F Zhang, L Yu, X Lin, P Cheng, L He, X Li, X Lu, Y Tan, H Yang, L Cai, C Zhang
Molecular Endocrinology 2015
Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows
H Akbar, F Batistel, JK Drackley, JJ Loor, W Feng
PloS one 2015
The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows
C Xu, Q Xu, Y Chen, W Yang, C Xia, H Yu, K Zhu, T Shen, Z Zhang
BMC veterinary research 2015
Skeletal muscle-specific eukaryotic translation initiation factor 2  phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism
M Miyake, A Nomura, A Ogura, K Takehana, Y Kitahara, K Takahara, K Tsugawa, C Miyamoto, N Miura, R Sato, K Kurahashi, HP Harding, M Oyadomari, D Ron, S Oyadomari
The FASEB Journal 2015
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver
S Raza-Iqbal, T Tanaka, M Anai, T Inagaki, Y Matsumura, K Ikeda, A Taguchi, FJ Gonzalez, J Sakai, T Kodama
Journal of Atherosclerosis and Thrombosis 2015
Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway
D Yu, X Ye, Q Wu, S Li, Y Yang, J He, Y Liu, X Zhang, Q Yuan, M Liu, D Li, G Ren
Endocrine 2015
Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders
J Zhang, Y Li
Frontiers in Endocrinology 2015
Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells
Y Wang, X Liu, L Hou, W Wu, S Zhao, Y Xiong
International journal of molecular sciences 2015
Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity
A Voigt, Y Katterle, M Kahle, R Kluge, A Schürmann, HG Joost, S Klaus
Genes & Nutrition 2015
Patterns of Circulating Fibroblast Growth Factor 21 in Subjects with and without Type 2 Diabetes
J Lu, H Yu, Y Mo, X Ma, Y Hao, W Lu, H Li, Y Bao, J Zhou, W Jia, W Feng
PloS one 2015
Wnt/ -catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development
Y Zhang, LK Yeh, S Zhang, M Call, Y Yuan, M Yasunaga, WW Kao, CY Liu
Development (Cambridge, England) 2015
Reply: CORRESPONDENCE
P Lu, W Xie
Hepatology 2015
Pharmacotherapy for Nonalcoholic Fatty Liver Disease
S Gawrieh, N Chalasani
Seminars in liver disease 2015
TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways
Jung JG, Yi SA, Choi SE, Kang Y, Kim TH, Jeon JY, Bae MA, Ahn JH, Jeong H, Hwang ES, Lee KW
Molecules and Cells 2015
BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies.
Catalán-García M, Garrabou G, Morén C, Guitart-Mampel M, Gonzalez-Casacuberta I, Hernando A, Gallego-Escuredo JM, Yubero D, Villarroya F, Montero R, O-Callaghan AS, Cardellach F, Grau JM
Molecular Medicine 2015
Play down protein to play up metabolism?
Timo D. Müller, Matthias H. Tschoep
Journal of Clinical Investigation 2014
Interplay between FGF21 and Insulin Action in the Liver for the Regulation of Metabolism
Brice Emanuelli, Sara Vienberg, Graham Smyth, Christine Cheng, Kristin Stanford, Manimozhiyan Arumugam, Mervyn D. Michael, Andrew Adams, Alexei Kharitonenkov, C. Ronald Kahn
Journal of Clinical Investigation 2014
FGF21 is an endocrine signal of protein restriction
Thomas Laeger, Tara Henagan, Diana Albarado, Leanne Redman, George A. Bray, Robert Noland, Heike Muenzberg-Gruening, Susan Hutson, Thomas Gettys, Michael W. Schwartz, Christopher Morrison
Journal of Clinical Investigation 2014
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)
P Jha, A Knopf, H Koefeler, M Mueller, C Lackner, G Hoefler, T Claudel, M Trauner
Biochimica et Biophysica Acta 2014
Syndecan-1 is required to maintain intradermal fat and prevent cold stress
I Kasza, Y Suh, D Wollny, RJ Clark, A Roopra, RJ Colman, OA MacDougald, TA Shedd, DW Nelson, MI Yen, CL Yen, CM Alexander
PLoS genetics 2014
Thyroid Hormone Regulation of Metabolism
R Mullur, YY Liu, GA Brent
Physiological reviews 2014
The brain and brown fat
C Contreras, F Gonzalez, J Fernø, C Diéguez, K Rahmouni, R Nogueiras, M López
Annals of Medicine 2014
Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism
HA Cyphert, KM Alonge, SM Ippagunta, FB Hillgartner
PloS one 2014
NT-PGC-1  Activation Attenuates High-Fat Diet-Induced Obesity by Enhancing Brown Fat Thermogenesis and Adipose Tissue Oxidative Metabolism
HJ Jun, Y Joshi, Y Patil, RC Noland, JS Chang
Diabetes 2014
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis
J Cantley
Mammalian Genome 2014
Bone Metabolism in Anorexia Nervosa
PK Fazeli, A Klibanski
Current Osteoporosis Reports 2014
Anorexia nervosa and bone metabolism
PK Fazeli, A Klibanski
Bone 2014
RECENT RESEARCH ON THE GROWTH PLATE: Recent insights into the regulation of the growth plate
JC Lui, O Nilsson, J Baron
Journal of Molecular Endocrinology 2014
Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
MK Brahma, RC Adam, NM Pollak, D Jaeger, KA Zierler, N Pocher, R Schreiber, M Romauch, T Moustafa, S Eder, T Ruelicke, K Preiss-Landl, A Lass, R Zechner, G Haemmerle
Journal of lipid research 2014
Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models
N Su, M Jin, L Chen
Bone Research 2014
Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice
, YF Qi, JR Chang, WW Lu, JS Zhang, SP Wang, SJ Cheng, M Zhang, Q Fan, Y Lv, H Zhu, MK Xin, Y Lv, JH Liu
Heart and Vessels 2014
Interleukin-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation
M Yamazaki, M Kawai, K Miyagawa, Y Ohata, K Tachikawa, S Kinoshita, J Nishino, K Ozono, T Michigami
Journal of Bone and Mineral Metabolism 2014
Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
M Gao, Y Ma, R Cui, D Liu
Journal of Controlled Release 2014
Serum fibroblast growth factor 21 levels are correlated with the severity of diabetic retinopathy
Y Lin, YC Xiao, H Zhu, QY Xu, L Qi, YB Wang, XJ Li, ML Zheng, RS Zhong, Y Zhang, XD Xu, B Wu, ZM Xu, XH Lu
Journal of Diabetes Research 2014
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Y Li, K Wong, A Giles, J Jiang, JW Lee, AC Adams, A Kharitonenkov, Q Yang, B Gao, L Guarente, M Zang
Gastroenterology 2014
Fibroblast growth factor (FGF) signaling in development and skeletal diseases
CM Teven, EM Farina, J Rivas, RR Reid
Genes & Diseases 2014
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
NA Khan, M Auranen, I Paetau, E Pirinen, L Euro, S Forsström, L Pasila, V Velagapudi, CJ Carroll, J Auwerx, A Suomalainen
EMBO Molecular Medicine 2014
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
J Mäkelä, TV Tselykh, F Maiorana, O Eriksson, H Do, G Mudò, LT Korhonen, N Belluardo, D Lindholm
SpringerPlus 2014
Myokines in insulin resistance and type 2 diabetes
K Eckardt, SW Görgens, S Raschke, J Eckel
Diabetologia 2014
Beyond intestinal soap—bile acids in metabolic control
F Kuipers, VW Bloks, AK Groen
Nature Reviews Endocrinology 2014
REV-ERB and ROR nuclear receptors as drug targets
DJ Kojetin, TP Burris
Nature Reviews Drug Discovery 2014
Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)
X Cheng, SG Vispute, J Liu, C Cheng, A Kharitonenkov, CD Klaassen
Toxicology and Applied Pharmacology 2014
Liraglutide Suppresses Obesity and Hyperglycemia Associated with Increases in Hepatic Fibroblast Growth Factor 21 Production in KKA(y) Mice
K Nonogaki, M Hazama, N Satoh
BioMed Research International 2014
Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training
RL Scalzo, GL Peltonen, GR Giordano, SE Binns, AL Klochak, HL Paris, MM Schweder, SE Szallar, LM Wood, DG Larson, GJ Luckasen, MS Hickey, C Bell
PloS one 2014
Molecular characterization and mapping of Fgf21 gene in a foodfish species asian seabass
L Wang, JH Xia, XJ Liu, P Liu, ZY Wan, GH Yue
PloS one 2014
Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
V Patel, R Adya, J Chen, M Ramanjaneya, MF Bari, SK Bhudia, EW Hillhouse, BK Tan, HS Randeva
PloS one 2014
A link between hepatic glucose production and peripheral energy metabolism via hepatokines
A Abdul-Wahed, A Gautier-Stein, S Casteras, M Soty, D Roussel, C Romenstaing, H Guillou, JA Tourette, N Pleche, C Zitoun, B Gri, A Sardella, F Rajas, G Mithieux
Molecular Metabolism 2014
Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
JM Gallego-Escuredo, J Gómez-Ambrosi, V Catalan, P Domingo, M Giralt, G Frühbeck, F Villarroya
International Journal of Obesity 2014
ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
XS Wan, XH Lu, YC Xiao, Y Lin, H Zhu, T Ding, Y Yang, Y Huang, Y Zhang, YL Liu, ZM Xu, J Xiao, XK Li
BioMed Research International 2014
Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents
A Bisgaard, K Sørensen, TH Johannsen, JW Helge, AM Andersson, A Juul
International Journal of Pediatric Endocrinology 2014
Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters
T Kelder, L Verschuren, B Ommen, AJ van Gool, M Radonjic
BMC Systems Biology 2014
FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
BM Owen, X Ding, DA Morgan, KC Coate, AL Bookout, K Rahmouni, SA Kliewer, DJ Mangelsdorf
Cell Metabolism 2014
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
N Tanaka, S Takahashi, ZZ Fang, T Matsubara, KW Krausz, A Qu, FJ Gonzalez
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014
Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females
LJ Hanks, K Casazza, AP Ashraf, S Wallace, OM Gutiérrez
Clinical Endocrinology 2014
The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway
S Vernia, J Cavanagh-Kyros, L Garcia-Haro, G Sabio, T Barrett, DY Jung, JK Kim, J Xu, HP Shulha, M Garber, G Gao, RJ Davis
Cell Metabolism 2014
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
JM Suh, JW Jonker, M Ahmadian, R Goetz, D Lackey, O Osborn, Z Huang, W Liu, E Yoshihara, TH van Dijk, R Havinga, W Fan, YQ Yin, RT Yu, C Liddle, AR Atkins, JM Olefsky, M Mohammadi, M Downes, RM Evans
Nature 2014
Transcriptional regulation of fibroblast growth factor 21 expression
KH Bae, JG Kim, KG Park
Endocrinology and Metabolism 2014
Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review
A Eshraghian, AH Jahromi
World journal of gastroenterology : WJG 2014
FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
KH Kim, MS Lee
Diabetes & Metabolism Journal 2014
Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
FM Fisher, PC Chui, IA Nasser, Y Popov, JC Cunniff, T Lundasen, A Kharitonenkov, D Schuppan, JS Flier, E Maratos-Flier
Gastroenterology 2014
A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation
W Wang, L Ma, M Liu, T Zhao, T Zhang, Y Yang, H Cao, X Han, D Li
Endocrine 2014
Lack of Day/Night variation in fibroblast growth factor 21 levels in young healthy men
JP Foo, KN Aronis, JP Chamberland, CS Mantzoros
International Journal of Obesity 2014
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
KR Markan, MC Naber, MK Ameka, MD Anderegg, DJ Mangelsdorf, SA Kliewer, M Mohammadi, MJ Potthoff
Diabetes 2014
Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats
WF Wang, SM Li, GP Ren, W Zheng, YJ Lu, YH Yu, WJ Xu, TH Li, LH Zhou, Y Liu, DS Li
Endocrine 2014
Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
SH Kim, KH Kim, HK Kim, MJ Kim, SH Back, M Konishi, N Itoh, MS Lee
Diabetologia 2014
The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study
KL Ong, AS Januszewski, R O’Connell, AJ Jenkins, A Xu, DR Sullivan, PJ Barter, WT Hung, RS Scott, MR Taskinen, AC Keech, KA Rye
Diabetologia 2014
Exercise-induced myokines in health and metabolic diseases
B So, HJ Kim, J Kim, W Song
Integrative Medicine Research 2014
Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
KP Stone, D Wanders, M Orgeron, CC Cortez, TW Gettys
Diabetes 2014
Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice
AC Thompson, MD Bruss, N Nag, A Kharitonenkov, AC Adams, MK Hellerstein, MA Avila
PloS one 2014
Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes
DV Lee, D Li, Q Yan, Y Zhu, B Goodwin, R Calle, MB Brenner, S Talukdar, X Chen
PloS one 2014
Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity
G Barraco, R Luciano, M Semeraro, P Prieto-Hontoria, M Manco
International journal of molecular sciences 2014
Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21
H Kim, R Mendez, Z Zheng, L Chang, J Cai, R Zhang, K Zhang
Endocrinology 2014
Fibroblast Growth Factor 21 and Thyroid Hormone Show Mutual Regulatory Dependency but Have Independent Actions In Vivo
EM Domouzoglou, M Fisher, I Astapova, EC Fox, A Kharitonenkov, JS Flier, AN Hollenberg, E Maratos-Flier
Endocrinology 2014
Kruppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice
KH Koh, X Pan, W Zhang, A McLachlan, R Urrutia, H Jeong
Molecular pharmacology 2014
Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis
S Jiang, C Yan, Q Fang, M Shao, Y Zhang, Y Liu, Y Deng, B Shan, J Liu, H Li, L Yang, J Zhou, Z Dai, Y Liu, W Jia
The Journal of biological chemistry 2014
Systemic regulation of mammalian ageing and longevity by brain sirtuins
A Satoh, S Imai
Nature Communications 2014
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat
J Suárez, P Rivera, S Arrabal, A Crespillo, A Serrano, E Baixeras, FJ Pavón, M Cifuentes, R Nogueiras, J Ballesteros, C Dieguez, FR de Fonseca
Disease models & mechanisms 2014
Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform.
Buffenstein R, Nelson OL, Corbit KC
Aging 2014
Basal and postprandial change in serum fibroblast growth factor-21 concentration in type 1 diabetic mellitus and in healthy controls.
Zibar K, Blaslov K, Bulum T, Ćuća JK, Smirčić-Duvnjak L
Endocrine 2014
Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids.
Villarroya J, Flachs P, Redondo-Angulo I, Giralt M, Medrikova D, Villarroya F, Kopecky J, Planavila A
Lipids 2014
Genetic models of PGC-1 and glucose metabolism and homeostasis
GC Rowe, Z Arany
Reviews in Endocrine and Metabolic Disorders 2013
Iron homeostasis in the liver
ER Anderson, YM Shah
Comprehensive Physiology 2013
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis
SH Zeisel
Clinical Chemistry and Laboratory Medicine 2013
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale
Nature Medicine 2013
The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes
S Ezzat, L Zheng, JC Florez, N Stefan, T Mayr, MM Hliang, K Jablonski, M Harden, A Stančáková, M Laakso, HU Haring, A Ullrich, SL Asa
Cell Metabolism 2013
Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations
Y Luo, C Yang, M Ye, C Jin, JL Abbruzzese, MH Lee, SC Yeung, WL McKeehan
Cancer & Metabolism 2013
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
WL Holland, AC Adams, JT Brozinick, HH Bui, Y Miyauchi, CM Kusminski, SM Bauer, M Wade, E Singhal, CC Cheng, K Volk, MS Kuo, R Gordillo, A Kharitonenkov, PE Scherer
Cell Metabolism 2013
Metreleptin Improves Blood Glucose in Patients With Insulin Receptor Mutations
RJ Brown, E Cochran, P Gorden
The Journal of clinical endocrinology and metabolism 2013
Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
RH Unger, PE Scherer, WL Holland, KG Kozminski
Molecular biology of the cell 2013
Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines
E Hui, A Xu, HB Yang, KS Lam
Journal of Diabetes Investigation 2013
Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis
AA Gupte, CJ Lyon, WA Hsueh
Current Diabetes Reports 2013
Adaptive thermogenesis in adipocytes: is beige the new brown?
J Wu, P Cohen, BM Spiegelman
Genes & development 2013
Fibroblast growth factor 21 mediates specific glucagon actions
KM Habegger, K Stemmer, C Cheng, TD Müller, KM Heppner, N Ottaway, J Holland, JL Hembree, D Smiley, V Gelfanov, R Krishna, AM Arafat, A Konkar, S Belli, M Kapps, SC Woods, SM Hofmann, D D'Alessio, PT Pfluger, D Perez-Tilve, RJ Seeley, M Konishi, N Itoh, A Kharitonenkov, J Spranger, RD DiMarchi, MH Tschöp
Diabetes 2013
The role of hepatokines in metabolism
N Stefan, HU Häring
Nature Reviews Endocrinology 2013
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
H Li, J Zhang, W Jia
Frontiers of Medicine 2013
Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta)
EB Nygaard, CL Møller, P Kievit, KL Grove, B Andersen
International Journal of Obesity 2013
Functional thermogenic beige adipogenesis is inducible in human neck fat
P Lee, CD Werner, E Kebebew, FS Celi
International Journal of Obesity 2013
FGF21 contributes to neuroendocrine control of female reproduction
BM Owen, AL Bookout, X Ding, VY Lin, SD Atkin, L Gautron, SA Kliewer, DJ Mangelsdorf
Nature Medicine 2013
Elevated FGF21 secretion, PGC-1  and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle
DR Crooks, TG Natarajan, SY Jeong, C Chen, SY Park, H Huang, MC Ghosh, WH Tong, RG Haller, C Wu, TA Rouault
Human Molecular Genetics 2013
Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
P Lee, J Linderman, S Smith, RJ Brychta, R Perron, C Idelson, CD Werner, KY Chen, FS Celi
Osteoporosis International 2013
Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health
SH Choi, ES Hong, S Lim
Frontiers in Endocrinology 2013
Determinants of GH resistance in malnutrition
PK Fazeli, A Klibanski
Journal of Endocrinology 2013
Molecular functions of thyroid hormones and their clinical significance in liver-related diseases
HC Chi, CY Chen, MM Tsai, CY Tsai, KH Lin
BioMed Research International 2013
Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV
B Lindegaard, T Hvid, T Grøndahl, C Frosig, J Gerstoft, P Hojman, BK Pedersen
PloS one 2013
Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue
SQ Liu, D Roberts, A Kharitonenkov, B Zhang, SM Hanson, YC Li, LQ Zhang, YH Wu
Scientific Reports 2013
Functional Role of PPARs in Ruminants: Potential Targets for Fine-Tuning Metabolism during Growth and Lactation
M Bionaz, S Chen, MJ Khan, JJ Loor
PPAR Research 2013
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
Y Murata, K Nishio, T Mochiyama, M Konishi, M Shimada, H Ohta, N Itoh
PloS one 2013
Association of fibroblast growth factor (FGF-21) as a biomarker with primary mitochondrial disorders, but not with secondary mitochondrial disorders (Friedreich Ataxia)
MH Salehi, B Kamalidehghan, M Houshmand, O Aryani, M Sadeghizadeh, MM Mossalaeie
Molecular Biology Reports 2013
Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
KH Kim, MS Lee
Reviews in Endocrine and Metabolic Disorders 2013
Inventing new medicines: The FGF21 story
A Kharitonenkov, AC Adams
Molecular Metabolism 2013
The therapeutic potential of brown adipose tissue
KI Stanford, LJ Goodyear
Hepatobiliary surgery and nutrition 2013
Stressed Liver and Muscle Call on Adipocytes with FGF21
Y Luo, WL McKeehan
Frontiers in Endocrinology 2013
Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus
L Xu, F Ping, J Yin, X Xiao, H Xiang, CM Ballantyne, H Wu, M Li
PloS one 2013
Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans
LK Heilbronn, LV Campbell, A Xu, D Samocha-Bonet
PloS one 2013
Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon
BA Neely, KP Carlin, JM Arthur, WE McFee, MG Janech
Frontiers in Endocrinology 2013
Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
AC Adams, T Coskun, CC Cheng, LS Farrell, SL Dubois, A Kharitonenkov
Molecular Metabolism 2013
Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21
ES Muise, S Souza, A Chi, Y Tan, X Zhao, F Liu, Q Dallas-Yang, M Wu, T Sarr, L Zhu, H Guo, Z Li, W Li, W Hu, G Jiang, CP Paweletz, RC Hendrickson, JR Thompson, J Mu, JP Berger, H Mehmet
PloS one 2013
Increased FGF21 plasma levels in humans with sepsis and SIRS
K Gariani, G Drifte, I Dunn-Siegrist, J Pugin, FR Jornayvaz
Endocrine Connections 2013
Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet
GM Raso, R Simeoli, R Russo, A Iacono, A Santoro, O Paciello, MC Ferrante, RB Canani, A Calignano, R Meli
PloS one 2013
High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism
E Benetti, R Mastrocola, M Rogazzo, F Chiazza, M Aragno, R Fantozzi, M Collino, MA Minetto
Mediators of Inflammation 2013
LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
AC Adams, CA Halstead, BC Hansen, AR Irizarry, JA Martin, SR Myers, VL Reynolds, HW Smith, VJ Wroblewski, A Kharitonenkov
PloS one 2013
Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
BK Tan, K Sivakumar, MF Bari, M Vatish, HS Randeva
PloS one 2013
Acute exercise induces FGF21 expression in mice and in healthy humans
KH Kim, SH Kim, YK Min, HM Yang, JB Lee, MS Lee
PloS one 2013
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein
R Smith, A Duguay, A Bakker, P Li, J Weiszmann, MR Thomas, BM Alba, X Wu, J Gupte, L Yang, J Stevens, A Hamburger, S Smith, J Chen, R Komorowski, KW Moore, MM Véniant, Y Li
PloS one 2013
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
C Yang, W Lu, T Lin, P You, M Ye, Y Huang, X Jiang, C Wang, F Wang, MH Lee, SC Yeung, RL Johnson, C Wei, RY Tsai, ML Frazier, WL McKeehan, Y Luo
BMC Gastroenterology 2013
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
A Kharitonenkov, JM Beals, R Micanovic, BA Strifler, R Rathnachalam, VJ Wroblewski, S Li, A Koester, AM Ford, T Coskun, JD Dunbar, CC Cheng, CC Frye, TF Bumol, DE Moller
PloS one 2013
Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression
S Feng, O Dakhova, CJ Creighton, M Ittmann
Cancer research 2013
Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice
Y Li, K Wong, K Walsh, B Gao, M Zang
The Journal of biological chemistry 2013
Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
BT Nelson, X Ding, J Boney-Montoya, RD Gerard, SA Kliewer, MT Andrews
PloS one 2013
Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein
X Tong, D Zhang, K Buelow, A Guha, B Arthurs, HJ Brady, L Yin
The Journal of biological chemistry 2013
FGF21 mediates the lipid metabolism response to amino acid starvation
AL de Sousa-Coelho, J Relat, E Hondares, A Pérez-Martí, F Ribas, F Villarroya, PF Marrero, D Haro
Journal of lipid research 2013
Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
JP Camporez, FR Jornayvaz, MC Petersen, D Pesta, BA Guigni, J Serr, D Zhang, M Kahn, VT Samuel, MJ Jurczak, GI Shulman
Endocrinology 2013
SUMO wars☆
FM Fisher, E Maratos-Flier
Molecular Metabolism 2013
Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels
Q Fang, H Li, Q Song, W Yang, X Hou, X Ma, J Lu, A Xu, W Jia
Diabetes care 2013
Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression
S Wu, T Grunwald, A Kharitonenkov, J Dam, R Jockers, FD Luca
The Journal of biological chemistry 2013
High Glucose Represses  -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor   Signaling
WY So, Q Cheng, L Chen, C Evans-Molina, A Xu, KS Lam, PS Leung
Diabetes 2013
Role of Fibroblast Growth Factor 21 in Biology of Glucagon
ED Berglund, RH Unger
Diabetes 2013
Roux-en-Y Gastric Bypass Surgery But Not Vertical Sleeve Gastrectomy Decreases Bone Mass in Male Rats
K Stemmer, M Bielohuby, BE Grayson, DP Begg, AP Chambers, C Neff, SC Woods, RG Erben, MH Tschöp, M Bidlingmaier, TL Clemens, RJ Seeley
Endocrinology 2013
Circulating Levels of FGF-21 in Obese Youth: Associations With Liver Fat Content and Markers of Liver Damage
C Giannini, AE Feldstein, N Santoro, G Kim, R Kursawe, B Pierpont, S Caprio
The Journal of clinical endocrinology and metabolism 2013
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
T Tanaka, JS Ngwa, FJ van Rooij, MC Zillikens, MK Wojczynski, AC Frazier-Wood, DK Houston, S Kanoni, RN Lemaitre, J Luan, V Mikkilä, F Renstrom, E Sonestedt, JH Zhao, AY Chu, L Qi, DI Chasman, MC de Oliveira Otto, EJ Dhurandhar, MF Feitosa, I Johansson, KT Khaw, KK Lohman, A Manichaikul, NM McKeown, D Mozaffarian, A Singleton, K Stirrups, J Viikari, Z Ye, S Bandinelli, I Barroso, P Deloukas, NG Forouhi, A Hofman, Y Liu, LP Lyytikäinen, KE North, M Dimitriou, G Hallmans, M Kähönen, C Langenberg, JM Ordovas, AG Uitterlinden, FB Hu, IP Kalafati, O Raitakari, OH Franco, A Johnson, V Emilsson, JA Schrack, RD Semba, DS Siscovick, DK Arnett, IB Borecki, PW Franks, SB Kritchevsky, T Lehtimäki, RJ Loos, M Orho-Melander, JI Rotter, NJ Wareham, JC Witteman, L Ferrucci, G Dedoussis, LA Cupples, JA Nettleton
The American journal of clinical nutrition 2013
New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
Chartoumpekis DV, Kensler TW
Current diabetes reviews 2013
Diabetes Mellitus: New Challenges and Innovative Therapies
Sena CM, Bento CF, Pereira P, Marques F, Seiça R
2013
Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine.
Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, Daviaud D, Mir L, Marques MA, Thalamas C, Valet P, Langin D, Moro C, Viguerie N
International Journal of Obesity 2013
Forever (FGF) 21.
Bass J
Nature Medicine 2013
Averting Comfortable Lifestyle Crises
Bilton R
Science Progress 2013
Brown Adipose Tissue Regulates Glucose Homeostasis and Insulin Sensitivity
Kristin Stanford, Roeland Middelbeek, Kristy Townsend, Ding An, Eva Nygaard, Kristen Hitchcox, Kathleen Markan, Kazuhiro Nakano, Jason Kim, Michael Hirshman, Yu-Hua Tseng, Laurie Goodyear
Journal of Clinical Investigation 2012
FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
MM Véniant, C Hale, J Helmering, MM Chen, S Stanislaus, J Busby, S Vonderfecht, J Xu, DJ Lloyd
PloS one 2012
Fasting-Induced FGF21 Is Repressed by LXR Activation via Recruitment of an HDAC3 Corepressor Complex in Mice
A Archer, N Venteclef, A Mode, M Pedrelli, C Gabbi, K Clément, P Parini, JÅ Gustafsson, M Korach-André
Molecular Endocrinology 2012
Metformin stimulates FGF21 expression in primary hepatocytes
EB Nygaard, SG Vienberg, C Ørskov, HS Hansen, B Andersen
Experimental Diabetes Research 2012
Endocrine FGFs and Klothos
M Kuro-o
2012
Syndromic Insulin Resistance: Models for the Therapeutic Basis of the Metabolic Syndrome and Other Targets of Insulin Resistance
P Gorden, ES Zadeh, E Cochran, RJ Brown
Endocrine Practice 2012
Dual actions of fibroblast growth factor 19 on lipid metabolism
X Wu, H Ge, H Baribault, J Gupte, J Weiszmann, B Lemon, J Gardner, P Fordstrom, J Tang, M Zhou, M Wang, Y Li
Journal of lipid research 2012
FGF21 Requires βklotho to Act In Vivo
AC Adams, CC Cheng, T Coskun, A Kharitonenkov, M Müller
PloS one 2012
Inhibition of Intestinal Bile Acid Transporter Slc10a2 Improves Triglyceride Metabolism and Normalizes Elevated Plasma Glucose Levels in Mice
T Lundåsen, EM Andersson, M Snaith, H Lindmark, J Lundberg, AM Östlund-Lindqvist, B Angelin, M Rudling, M Pietropaolo
PloS one 2012
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
W Wei, PA Dutchak, X Wang, X Ding, X Wang, AL Bookout, R Goetz, M Mohammadi, RD Gerard, PC Dechow, DJ Mangelsdorf, SA Kliewer, Y Wan
Proceedings of the National Academy of Sciences 2012
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
R Goetz, M Ohnishi, S Kir, H Kurosu, L Wang, J Pastor, J Ma, W Gai, M Kuro-o, MS Razzaque, M Mohammadi
The Journal of biological chemistry 2012
Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands
R Goetz, M Ohnishi, X Ding, H Kurosu, L Wang, J Akiyoshi, J Ma, W Gai, Y Sidis, N Pitteloud, M Kuro-O, MS Razzaque, M Mohammadi
Molecular and cellular biology 2012
Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor
C Streicher, U Zeitz, O Andrukhova, A Rupprecht, E Pohl, TE Larsson, W Windisch, B Lanske, RG Erben
Endocrinology 2012
Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers
SA Lee, E Jeong, EH Kim, MS Shin, JY Hwang, EH Koh, WJ Lee, JY Park, MS Kim
Diabetes & Metabolism Journal 2012
Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21
HA Cyphert, X Ge, AB Kohan, LM Salati, Y Zhang, FB Hillgartner
The Journal of biological chemistry 2012
Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
C Yang, C Jin, X Li, F Wang, WL McKeehan, Y Luo
PloS one 2012
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
MJ Potthoff, SA Kliewer, DJ Mangelsdorf
Genes & development 2012
The role of Klotho in energy metabolism
MS Razzaque
Nature Reviews Endocrinology 2012
βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
X Ding, J Boney-Montoya, BM Owen, AL Bookout, KC Coate, DJ Mangelsdorf, SA Kliewer
Cell Metabolism 2012
Fibroblast Growth Factor 21 Predicts the Metabolic Syndrome and Type 2 Diabetes in Caucasians
T Bobbert, F Schwarz, A Fischer-Rosinsky, AF Pfeiffer, M Möhlig, K Mai, J Spranger
Diabetes care 2012
Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress
C Yang, C Wang, M Ye, C Jin, W He, F Wang, WL McKeehan, Y Luo
Nutrition & Metabolism 2012
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
PA Dutchak, T Katafuchi, AL Bookout, JH Choi, RT Yu, DJ Mangelsdorf, SA Kliewer
Cell 2012
Fibroblast Growth Factor 21: A Novel Metabolic Regulator
JA Seo, NH Kim
Diabetes & Metabolism Journal 2012
Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs
J Varady, R Ringseis, K Eder
Lipids in Health and Disease 2012
In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents
CA Chen, PC Carolan, JP Annes
PloS one 2012
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
FM Fisher, S Kleiner, N Douris, EC Fox, RJ Mepani, F Verdeguer, J Wu, A Kharitonenkov, JS Flier, E Maratos-Flier, BM Spiegelman
Genes & development 2012
Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
AC Adams, T Coskun, AR Rovira, MA Schneider, DW Raches, R Micanovic, HA Bina, JD Dunbar, A Kharitonenkov
PloS one 2012
Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels
D Cuevas-Ramos, P Almeda-Valdés, CE Meza-Arana, G Brito-Córdova, FJ Gómez-Pérez, R Mehta, J Oseguera-Moguel, CA Aguilar-Salinas
PloS one 2012
Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells
Y Liu, C Wang, Y Wang, Z Ma, J Xiao, C McClain, X Li, W Feng
Toxicology and Applied Pharmacology 2012
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
AC Adams, C Yang, T Coskun, CC Cheng, RE Gimeno, Y Luo, A Kharitonenkov
Molecular Metabolism 2012
Mitochondria: In Sickness and in Health
J Nunnari, A Suomalainen
Cell 2012
Nrf2 Deficiency Improves Glucose Tolerance in Mice Fed a High-Fat Diet
YK Zhang, KC Wu, J Liu, CD Klaassen
Toxicology and Applied Pharmacology 2012
Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction
JA Fletcher, GM Meers, MH Laughlin, JA Ibdah, JP Thyfault, RS Rector
Applied Physiology, Nutrition, and Metabolism 2012
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
KH Kim, YT Jeong, H Oh, SH Kim, JM Cho, YN Kim, SS Kim, DH Kim, KY Hur, HK Kim, TH Ko, J Han, HL Kim, J Kim, SH Back, M Komatsu, H Chen, DC Chan, M Konishi, N Itoh, CS Choi, MS Lee
Nature Medicine 2012
Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
AM Arafat, P Kaczmarek, M Skrzypski, E Pruszyńska-Oszmalek, P Kołodziejski, D Szczepankiewicz, M Sassek, T Wojciechowicz, B Wiedenmann, AF Pfeiffer, KW Nowak, MZ Strowski
Diabetologia 2012
Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism
MY Sun, E Yoo, BJ Green, SM Altamentova, DM Kilkenny, JV Rocheleau
Biophysical Journal 2012
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Y Zhang, Y Xie, ED Berglund, KC Coate, TT He, T Katafuchi, G Xiao, MJ Potthoff, W Wei, Y Wan, RT Yu, RM Evans, SA Kliewer, DJ Mangelsdorf
eLife 2012
Methionine-restricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density
GP Ables, CE Perrone, D Orentreich, N Orentreich
PloS one 2012
Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue
YW Teng, JM Ellis, RA Coleman, SH Zeisel
The Journal of biological chemistry 2012
Liraglutide increases FGF-21 activity and insulin sensitivity in high fat diet and adiponectin knockdown induced insulin resistance
M Yang, L Zhang, C Wang, H Liu, G Boden, G Yang, L Li
PloS one 2012
Fgf signaling in adipocytes as a target for metabolic diseases
H Ohta, N Itoh
Molecular Metabolism 2012
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
R Hecht, YS Li, J Sun, E Belouski, M Hall, T Hager, J Yie, W Wang, D Winters, S Smith, C Spahr, LT Tam, Z Shen, S Stanislaus, N Chinookoswong, Y Lau, A Sickmier, ML Michaels, T Boone, MM Véniant, J Xu
PloS one 2012
Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
P Lee, RJ Brychta, J Linderman, S Smith, KY Chen, FS Celi
The Journal of clinical endocrinology and metabolism 2012
Pharmacokinetic properties of 2nd-generation fibroblast growth factor-1 mutants for therapeutic application
X Xia, JP Babcock, SI Blaber, KM Harper, M Blaber
PloS one 2012
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
S Wu, A Levenson, A Kharitonenkov, FD Luca
The Journal of biological chemistry 2012
Cell biology. FGF21 takes a fat bite
C Cantó, J Auwerx
Science 2012
Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
AY Ming, E Yoo, EN Vorontsov, SM Altamentova, DM Kilkenny, JV Rocheleau
The Journal of biological chemistry 2012
FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis
KR Feingold, C Grunfeld, JG Heuer, A Gupta, M Cramer, T Zhang, JK Shigenaga, SM Patzek, ZW Chan, A Moser, H Bina, A Kharitonenkov
Endocrinology 2012
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)
HT Do, TV Tselykh, J Mäkelä, TH Ho, VM Olkkonen, BC Bornhauser, L Korhonen, N Zelcer, D Lindholm
The Journal of biological chemistry 2012
Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
MM Seldin, JM Peterson, MS Byerly, Z Wei, GW Wong
The Journal of biological chemistry 2012
Role of osteoglycin in the linkage between muscle and bone
K Tanaka, E Matsumoto, Y Higashimaki, T Katagiri, T Sugimoto, S Seino, H Kaji
The Journal of biological chemistry 2012
Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3
H Li, Z Gao, J Zhang, X Ye, A Xu, J Ye, W Jia
Diabetes 2012
Brown adipose tissue
K Townsend, YH Tseng
Adipocyte 2012
Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging
RD Semba, K Sun, JM Egan, C Crasto, OD Carlson, L Ferrucci
The Journal of clinical endocrinology and metabolism 2012
Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
FM Fisher, JL Estall, AC Adams, PJ Antonellis, HA Bina, JS Flier, A Kharitonenkov, BM Spiegelman, E Maratos-Flier
Endocrinology 2011
Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides
C Watanabe, Y Seino, H Miyahira, M Yamamoto, A Fukami, N Ozaki, Y Takagishi, J Sato, T Fukuwatari, K Shibata, Y Oiso, Y Murata, Y Hayashi
Diabetes 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells
I Loeffler, U Hopfer, D Koczan, G Wolf
Journal of the American Society of Nephrology : JASN 2011
Bile Acid Sequestration Reduces Plasma Glucose Levels in db/db Mice by Increasing Its Metabolic Clearance Rate
M Meissner, H Herrema, TH van Dijk, A Gerding, R Havinga, T Boer, M Müller, DJ Reijngoud, AK Groen, F Kuipers
PloS one 2011
The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis
LA Solt, DJ Kojetin, TP Burris
Future Medicinal Chemistry 2011
The Neuroendocrine Basis of Anorexia Nervosa and Its Impact on Bone Metabolism
M Misra, A Klibanski
Neuroendocrinology 2011
Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial
SL Samson, P Sathyanarayana, M Jogi, EV Gonzalez, A Gutierrez, R Krishnamurthy, R Muthupillai, L Chan, M Bajaj
Diabetologia 2011
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
L Kong, W Ren, W Li, S Zhao, H Mi, R Wang, Y Zhang, W Wu, Y Nan, J Yu
Lipids in Health and Disease 2011
Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study
H Yan, M Xia, X Chang, Q Xu, H Bian, M Zeng, S Rao, X Yao, Y Tu, W Jia, X Gao
PloS one 2011
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue*
E Hondares, R Iglesias, A Giralt, FJ Gonzalez, M Giralt, T Mampel, F Villarroya
The Journal of biological chemistry 2011
Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C
Y Jiao, J Zhang, J Yan, J Stuart, G Gibson, L Lu, R Willaims, YJ Wang, W Gu
Genetics and molecular biology 2011
The lighter side of BDNF
EE Noble, CJ Billington, CM Kotz, CF Wang
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2011
Effects of Short-Term Continuous Subcutaneous Insulin Infusion on Fasting Plasma Fibroblast Growth Factor-21 Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
M Yang, J Dong, H Liu, L Li, G Yang
PloS one 2011
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
J Mu, J Pinkstaff, Z Li, L Skidmore, N Li, H Myler, Q Dallas-Yang, AM Putnam, J Yao, S Bussell, M Wu, TC Norman, CG Rodriguez, B Kimmel, JM Metzger, A Manibusan, D Lee, DM Zaller, BB Zhang, RD DiMarchi, JP Berger, DW Axelrod
Diabetes 2011
Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1
A Beenken, AV Eliseenkova, OA Ibrahimi, SK Olsen, M Mohammadi
The Journal of biological chemistry 2011
Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity
BK Tan, M Hallschmid, R Adya, W Kern, H Lehnert, HS Randeva
Diabetes 2011
Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice
DV Chartoumpekis, PG Ziros, AI Psyrogiannis, AG Papavassiliou, VE Kyriazopoulou, GP Sykiotis, IG Habeos
Diabetes 2011
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
W Chen, RL Hoo, M Konishi, N Itoh, PC Lee, H Ye, KS Lam, A Xu
The Journal of biological chemistry 2011
Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
X Ge, C Chen, X Hui, Y Wang, KS Lam, A Xu
The Journal of biological chemistry 2011
High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes: A 5.4-year population-based prospective study in Chinese subjects
C Chen, BM Cheung, AW Tso, Y Wang, LS Law, KL Ong, NM Wat, A Xu, KS Lam
Diabetes care 2011
Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis
EM Domouzoglou, E Maratos-Flier
The American journal of clinical nutrition 2011
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study.
Suomalainen A, Elo JM, Pietiläinen KH, Hakonen AH, Sevastianova K, Korpela M, Isohanni P, Marjavaara SK, Tyni T, Kiuru-Enari S, Pihko H, Darin N, Õunap K, Kluijtmans LA, Paetau A, Buzkova J, Bindoff LA, Annunen-Rasila J, Uusimaa J, Rissanen A, Yki-Järvinen H, Hirano M, Tulinius M, Smeitink J, Tyynismaa H
The Lancet Neurology 2011
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
AM Miller, DL Asquith, AJ Hueber, LA Anderson, WM Holmes, AN McKenzie, D Xu, N Sattar, IB McInnes, FY Liew
Circulation research 2010
Maternal overweight programs insulin and adiponectin signaling in the offspring
K Shankar, P Kang, A Harrell, Y Zhong, JC Marecki, MJ Ronis, TM Badger
Endocrinology 2010
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
MD Chau, J Gao, Q Yang, Z Wu, J Gromada
Proceedings of the National Academy of Sciences 2010
Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding*
X Tong, M Muchnik, Z Chen, M Patel, N Wu, S Joshi, L Rui, MA Lazar, L Yin
The Journal of biological chemistry 2010
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
FR Jornayvaz, MJ Jurczak, HY Lee, AL Birkenfeld, DW Frederick, D Zhang, XM Zhang, VT Samuel, GI Shulman
American journal of physiology. Endocrinology and metabolism 2010
FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model
T Uonaga, K Toyoda, T Okitsu, X Zhuang, S Yamane, S Uemoto, N Inagaki
Islets 2010
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
M Fisher, PC Chui, PJ Antonellis, HA Bina, A Kharitonenkov, JS Flier, E Maratos-Flier
2010
Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
DA Sarruf, JP Thaler, GJ Morton, J German, JD Fischer, K Ogimoto, MW Schwartz
Diabetes 2010
Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat
E Hondares, M Rosell, FJ Gonzalez, M Giralt, R Iglesias, F Villarroya
Cell Metabolism 2010
Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
J Dushay, PC Chui, GS Gopalakrishnan, M VarelaRey, M Crawley, FM Fisher, MK Badman, ML MartinezChantar, E MaratosFlier
Gastroenterology 2010
SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo
MJ Jurynec, DJ Grunwald
Disease models & mechanisms 2010
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
RH Houtkooper, C Cantó, RJ Wanders, J Auwerx
Endocrine reviews 2010
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
ED Berglund, CY Li, HA Bina, SE Lynes, MD Michael, AB Shanafelt, A Kharitonenkov, DH Wasserman
Endocrinology 2009
FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
DJ Shin, TF Osborne
The Journal of biological chemistry 2009
FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
MJ Potthoff, T Inagaki, S Satapati, X Ding, T He, R Goetz, M Mohammadi, BN Finck, DJ Mangelsdorf, SA Kliewer, SC Burgess
Proceedings of the National Academy of Sciences 2009
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
X Wu, H Ge, B Lemon, S Vonderfecht, J Weiszmann, R Hecht, J Gupte, T Hager, Z Wang, R Lindberg, Y Li
The Journal of biological chemistry 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Fibroblast growth factor 21: an overview from a clinical perspective
M Rydén
Cellular and Molecular Life Sciences 2009
Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis.
Wu X, Li Y
Aging 2009
Hypoxia and low‐nutrition double stress induces aggressiveness in a murine model of melanoma
Osawa T, Muramatsu M, Watanabe M, Shibuya M
Cancer Science 2009
Partial Resistance to Peroxisome Proliferator-Activated Receptor-  Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism
S Satapati, T He, T Inagaki, M Potthoff, ME Merritt, V Esser, DJ Mangelsdorf, SA Kliewer, JD Browning, SC Burgess
Diabetes 2008
Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease
Giovanni Corsetti, Evasio Pasini, Tiziano M Scarabelli, Claudia Romano, Pratik R Agrawal, Carol Chen-Scarabelli, Richard Knight, Louis Saravolatz, Jagat Narula, Mario Ferrari-Vivaldi, Vincenzo Flati, Deodato Assanelli, Francesco S Dioguardi
Journal of Geriatric Cardiology
Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults
Y Huang, JM Gao, CM Zhang, HC Zhao, Y Zhao, R Li, Y Yu, J Qiao
Reproduction 2016
Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
G Singhal, M Fisher, MJ Chee, TG Tan, AE Ouaamari, AC Adams, R Najarian, RN Kulkarni, C Benoist, JS Flier, E Maratos-Flier, J Sastre
PloS one 2016
Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism
M Kuro-o
Nature Reviews Nephrology 2013
Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway
JP Foo, KN Aronis, JP Chamberland, J Paruthi, HS Moon, CS Mantzoros
Diabetes care 2012
Clinical Significance of FGF-23 in Patients with CKD
D Russo, Y Battaglia
International Journal of Nephrology 2011
FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology
Y Murata, M Konishi, N Itoh
Journal of nutrition and metabolism 2011
Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?
T Uebanso, Y Taketani, H Yamamoto, K Amo, H Ominami, H Arai, Y Takei, M Masuda, A Tanimura, N Harada, H Yamanaka-Okumura, E Takeda
PloS one 2011
A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol
Z Huang, H Wang, M Lu, C Sun, X Wu, Y Tan, C Ye, G Zhu, X Wang, L Cai, X Li
PloS one 2011
Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese
Z Lin, Z Zhou, Y Liu, Q Gong, X Yan, J Xiao, X Wang, S Lin, W Feng, X Li
PloS one 2011
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
AL Wu, S Coulter, C Liddle, A Wong, J Eastham-Anderson, DM French, AS Peterson, J Sonoda
PloS one 2011
Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
DV Chartoumpekis, IG Habeos, PG Ziros, AI Psyrogiannis, VE Kyriazopoulou, AG Papavassiliou
Molecular Medicine 2011
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease
N Itoh
Cell and Tissue Research 2010
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
K Tomiyama, R Maeda, I Urakawa, Y Yamazaki, T Tanaka, S Ito, Y Nabeshima, T Tomita, S Odori, K Hosoda, K Nakao, A Imura, Y Nabeshima
Proceedings of the National Academy of Sciences 2010
Metabolic Regulator βKlotho Interacts with Fibroblast Growth Factor Receptor 4 (FGFR4) to Induce Apoptosis and Inhibit Tumor Cell Proliferation*
Y Luo, C Yang, W Lu, R Xie, C Jin, P Huang, F Wang, WL McKeehan
The Journal of biological chemistry 2010
Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
KF Tacer, AL Bookout, X Ding, H Kurosu, GB John, L Wang, R Goetz, M Mohammadi, M Kuro-o, DJ Mangelsdorf, SA Kliewer
Molecular Endocrinology 2010
The Role of PPARα Activation in Liver and Muscle
L Burri, GH Thoresen, RK Berge
PPAR Research 2010
Cellular bioenergetics as a target for obesity therapy
YH Tseng, AM Cypess, CR Kahn
Nature Reviews Drug Discovery 2010
Brown fat as a therapy for obesity and diabetes
AM Cypess, CR Kahn
Current Opinion in Endocrinology, Diabetes and Obesity 2010
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner
AC Adams, I Astapova, FM Fisher, MK Badman, KE Kurgansky, JS Flier, AN Hollenberg, E Maratos-Flier
The Journal of biological chemistry 2010
Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile
Z Lin, Z Wu, X Yin, Y Liu, X Yan, S Lin, J Xiao, X Wang, W Feng, X Li
PloS one 2010
FGF21 signalling pathway and metabolic traits - genetic association analysis
BM Kaess, TA Barnes, K Stark, FJ Charchar, D Waterworth, K Song, WY Wang, P Vollenweider, G Waeber, V Mooser, E Zukowska-Szczechowska, NJ Samani, C Hengstenberg, M Tomaszewski
European journal of human genetics : EJHG 2010
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha
Y Wang, LA Solt, TP Burris
The Journal of biological chemistry 2010
High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli
H Wang, Y Xiao, L Fu, H Zhao, Y Zhang, X Wan, Y Qin, Y Huang, H Gao, X Li
BMC Biotechnology 2010
The FGF family: biology, pathophysiology and therapy
A Beenken, M Mohammadi
Nature Reviews Drug Discovery 2009
Klotho and aging
M Kuro-o
Biochimica et Biophysica Acta 2009
Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix
J Kalinina, SA Byron, HP Makarenkova, SK Olsen, AV Eliseenkova, WJ Larochelle, M Dhanabal, S Blais, DM Ornitz, LA Day, TA Neubert, PM Pollock, M Mohammadi
Molecular and cellular biology 2009
PGC-1  negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb  axis
JL Estall, JL Ruas, CS Choi, D Laznik, M Badman, E Maratos-Flier, GI Shulman, BM Spiegelman
Proceedings of the National Academy of Sciences 2009
Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
K Mai, J Andres, K Biedasek, J Weicht, T Bobbert, M Sabath, S Meinus, F Reinecke, M Möhlig, MO Weickert, M Clemenz, AF Pfeiffer, U Kintscher, S Spuler, J Spranger
Diabetes 2009
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
AO Chavez, M Molina-Carrion, MA Abdul-Ghani, F Folli, RA Defronzo, D Tripathy
Diabetes care 2009
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
MK Badman, A Koester, JS Flier, A Kharitonenkov, E Maratos-Flier
Endocrinology 2009
A Very Low Carbohydrate Ketogenic Diet Improves Glucose Tolerance in ob/ob Mice Independent of Weight Loss
MK Badman, AR Kennedy, AC Adams, P Pissios, E Maratos-Flier
American journal of physiology. Endocrinology and metabolism 2009
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms
JN Feige, A Gerber, C Casals-Casas, Q Yang, C Winkler, E Bedu, M Bueno, L Gelman, J Auwerx, FJ Gonzalez, B Desvergne
Environmental Health Perspectives 2009
Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa
PK Fazeli, M Misra, M Goldstein, KK Miller, A Klibanski
The Journal of clinical endocrinology and metabolism 2009
Fibroblast growth factor 21: from pharmacology to physiology
SA Kliewer, DJ Mangelsdorf
The American journal of clinical nutrition 2009
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
P Hojman, M Pedersen, AR Nielsen, R Krogh-Madsen, C Yfanti, T Akerstrom, S Nielsen, BK Pedersen
Diabetes 2009
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice
X Hui, W Zhu, Y Wang, KS Lam, J Zhang, D Wu, EW Kraegen, Y Li, A Xu
The Journal of biological chemistry 2009
Identification of MUP1 as a regulator for glucose and lipid metabolism in mice
Y Zhou, L Jiang, L Rui
The Journal of biological chemistry 2009
Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis
X Huang, C Yang, C Jin, Y Luo, F Wang, WL McKeehan
Molecular Carcinogenesis 2009
Renal senescence in 2008: progress and challenges
XJ Zhou, R Saxena, Z Liu, ND Vaziri, FG Silva
International Urology and Nephrology 2008
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
X Wu, B Lemon, XF Li, J Gupte, J Weiszmann, J Stevens, N Hawkins, W Shen, R Lindberg, JL Chen, H Tian, Y Li
The Journal of biological chemistry 2008
βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c
M Suzuki, Y Uehara, K Motomura-Matsuzaka, J Oki, Y Koyama, M Kimura, M Asada, A Komi-Kuramochi, S Oka, T Imamura
Molecular Endocrinology 2008
Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
T Inagaki, VY Lin, R Goetz, M Mohammadi, DJ Mangelsdorf, SA Kliewer
Cell Metabolism 2008
Type 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype
B Zhu, L Zhang, M Alexeyev, DF Alvarez, SJ Strada, T Stevens
American journal of physiology. Lung cellular and molecular physiology 2008
FGF21 is an Akt-regulated myokine
Y Izumiya, HA Bina, N Ouchi, Y Akasaki, A Kharitonenkov, K Walsh
FEBS Letters 2008
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
J Xu, DJ Lloyd, C Hale, S Stanislaus, M Chen, G Sivits, S Vonderfecht, R Hecht, YS Li, RA Lindberg, JL Chen, DY Jung, Z Zhang, HJ Ko, JK Kim, MM Veniant
Diabetes 2008
Serum Levels of the Adipokine FGF21 Depend on Renal Function
S Stein, A Bachmann, U Lossner, J Kratzsch, M Bluher, M Stumvoll, M Fasshauer
Diabetes care 2008
Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes
H Wang, L Qiang, SR Farmer
Molecular and cellular biology 2008
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
H Kurosu, M Choi, Y Ogawa, AS Dickson, R Goetz, AV Eliseenkova, M Mohammadi, KP Rosenblatt, SA Kliewer, M Kuro-o
The Journal of biological chemistry 2007
BetaKlotho is required for metabolic activity of fibroblast growth factor 21
Y Ogawa, H Kurosu, M Yamamoto, A Nandi, KP Rosenblatt, R Goetz, AV Eliseenkova, M Mohammadi, M Kuro-o
Proceedings of the National Academy of Sciences 2007
Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease
JL Staudinger, K Lichti
Molecular Pharmaceutics 2007
Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members
R Goetz, A Beenken, OA Ibrahimi, J Kalinina, SK Olsen, AV Eliseenkova, CF Xu, TA Neubert, F Zhang, RJ Linhardt, X Yu, KE White, T Inagaki, SA Kliewer, M Yamamoto, H Kurosu, Y Ogawa, M Kuro-o, B Lanske, MS Razzaque, M Mohammadi
Molecular and cellular biology 2007
The fasting polypeptide FGF21 can enter brain from blood
H Hsuchou, W Pan, AJ Kastin
Peptides 2007
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3
VP Eswarakumar, J Schlessinger
Proceedings of the National Academy of Sciences 2007
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
X Zhang, OA Ibrahimi, SK Olsen, H Umemori, M Mohammadi, DM Ornitz
The Journal of biological chemistry 2006

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