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Citations to this article

IL-1 mediates TNF-induced osteoclastogenesis
Shi Wei, … , F. Patrick Ross, Steven L. Teitelbaum
Shi Wei, … , F. Patrick Ross, Steven L. Teitelbaum
Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):282-290. https://doi.org/10.1172/JCI23394.
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Article Bone biology

IL-1 mediates TNF-induced osteoclastogenesis

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Abstract

TNF-induced receptor activator NF-κB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. We found that this process was abolished by IL-1 receptor antagonist (IL-1Ra) or in stromal cells derived from type I IL-1 receptor–deficient (IL-1RI–deficient) mice. Reflecting sequential signaling of the cytokines TNF and IL-1, TNF induces stromal cell expression of IL-1 and IL-1RI. These data suggest that TNF regulates RANKL expression via IL-1, and, therefore, IL-1 plays a role in TNF-induced periarticular osteolysis. Consistent with this posture, TNF-stimulated osteoclastogenesis in cultures consisting of WT marrow macrophages and stromal cells exposed to IL-1Ra or in cocultures established with IL-1RI–deficient stromal cells was reduced approximately 50%. The same magnitude of osteoclast inhibition occurred in IL-1RI–deficient mice following TNF administration in vivo. Like TNF, IL-1 directly targeted osteoclast precursors and promoted the osteoclast phenotype in a TNF-independent manner in the presence of permissive levels of RANKL. IL-1 is able to induce RANKL expression by stromal cells and directly stimulate osteoclast precursor differentiation under the aegis of p38 MAPK. Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors.

Authors

Shi Wei, Hideki Kitaura, Ping Zhou, F. Patrick Ross, Steven L. Teitelbaum

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International journal of molecular sciences 2020
Chronic Exposure of Gingival Fibroblasts to TLR2 or TLR4 Agonist Inhibits Osteoclastogenesis but Does Not Affect Osteogenesis
GD Karlis, E Schöningh, ID Jansen, T Schoenmaker, JM Hogervorst, HA van Veen, CG Moonen, KB Łagosz-Ćwik, T Forouzanfar, TJ de Vries
Frontiers in immunology 2020
Inflammation time-axis in aseptic loosening of total knee arthroplasty: A preliminary study
T Dyskova, E Kriegova, Z Slobodova, S Zehnalova, M Kudelka, P Schneiderova, R Fillerova, J Gallo, L Cordova
PloS one 2019
The Autophagy in Osteoimmonology: Self-Eating, Maintenance, and Beyond
L Xiao, Y Xiao
Frontiers in Endocrinology 2019
Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
D Harmer, C Falank, MR Reagan
Frontiers in Endocrinology 2019
S1P-S1PR1 Signaling: the “Sphinx” in Osteoimmunology
L Xiao, Y Zhou, T Friis, K Beagley, Y Xiao
Frontiers in immunology 2019
Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases
F Coury, O Peyruchaud, I Machuca-Gayet
Frontiers in immunology 2019
Bone Regeneration Induced by Strontium Folate Loaded Biohybrid Scaffolds
M Martín-del-Campo, JG Sampedro, ML Flores-Cedillo, R Rosales-Ibañez, L Rojo
Molecules (Basel, Switzerland) 2019
Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms
C Alvarez, G Monasterio, F Cavalla, LA Córdova, M Hernández, D Heymann, GP Garlet, T Sorsa, P Pärnänen, HM Lee, LM Golub, R Vernal, A Kantarci
Frontiers in immunology 2019
Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells
LM Luttrell, MS Dar, D Gesty-Palmer, HM El-Shewy, KM Robinson, CJ Haycraft, JL Barth, C Zhang
PloS one 2019
Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms
S Nardecchia, R Auricchio, V Discepolo, R Troncone
Frontiers in Pediatrics 2019
Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis
CG Fenton, JM Webster, CS Martin, S Fareed, C Wehmeyer, H Mackie, R Jones, AP Seabright, JW Lewis, YC Lai, CS Goodyear, SW Jones, MS Cooper, GG Lavery, R Langen, K Raza, RS Hardy
Arthritis Research & Therapy 2019
Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity
SH Lu, YJ Hsia, KC Shih, TC Chou
Marine drugs 2019
Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB–NFATc1 signal pathway
J Yang, R Tang, J Yi, Y Chen, X Li, T Yu, J Fei
The FASEB Journal 2019
Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κ B Kinase and Inflammasome-Mediated Interleukin-1 β Secretion
HY Kim, KS Kim, MJ Kim, HS Kim, KY Lee, KW Kang
Oxidative medicine and cellular longevity 2019
The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α
J Yu, E Canalis
The Journal of biological chemistry 2019
Omnipresence of inflammasome activities in inflammatory bone diseases
Y Alippe, G Mbalaviele
Seminars in Immunopathology 2019
Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss
JM Webster, CG Fenton, R Langen, RS Hardy
International journal of molecular sciences 2019
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation
K Caution, N Young, F Robledo-Avila, K Krause, AA Khweek, K Hamilton, A Badr, A Vaidya, K Daily, H Gosu, MN Anne, M Eltobgy, D Dakhlallah, S Argwal, S Estfanous, X Zhang, S Partida-Sanchez, MA Gavrilin, WN Jarjour, AO Amer
Frontiers in immunology 2019
Quantification of pro-inflammatory cytokines and osteoclastogenesis markers in successful and failed orthodontic mini-implants
MC Andrucioli, MA Matsumoto, SY Fukada, MC Saraiva, AZ Bergamo, FL Romano, RA da Silva, LA da Silva, P Nelson-Filho
Journal of applied oral science : revista FOB 2019
Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis
M Simão, A Camacho, A Ostertag, M Cohen-Solal, IJ Pinto, G Porto, EH Korng, ML Cancela, K Pantopoulos
PloS one 2018
Innate Immunity to Staphylococcus aureus : Evolving Paradigms in Soft Tissue and Invasive Infections
SL Brandt, NE Putnam, JE Cassat, CH Serezani
Journal of immunology (Baltimore, Md. : 1950) 2018
C/EBPα and PU.1 exhibit different responses to RANK signaling for osteoclastogenesis
J Jules, YP Li, W Chen
Bone 2018
Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis
SY Gwon, KJ Rhee, HJ Sung
International journal of medical sciences 2018
Regulation of Osteoclast Differentiation by Cytokine Networks
DS Amarasekara, H Yun, S Kim, N Lee, H Kim, J Rho
Immune Network 2018
Tannerella forsythia -produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes
RP Settem, K Honma, M Shankar, M Li, M LaMonte, D Xu, RJ Genco, RW Browne, A Sharma
Molecular Oral Microbiology 2018
Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF- α
C Liu, H Zhang, X Tang, R Feng, G Yao, W Chen, W Li, J Liang, X Feng, L Sun
Stem Cells International 2018
Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine
JH Werner, JH Rosenberg, KL Keeley, DK Agrawal
Expert Review of Clinical Immunology 2018
Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals
C Wang, S Hockerman, EJ Jacobsen, Y Alippe, SR Selness, HR Hope, JL Hirsch, SJ Mnich, MJ Saabye, WF Hood, SL Bonar, Y Abu-Amer, A Haimovich, HM Hoffman, JB Monahan, G Mbalaviele
Journal of Experimental Medicine 2018
The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis
Kim H, Kajikawa T, Walsh MC, Takegahara N, Jeong YH, Hajishengallis G, Choi Y
BMB Reports 2018
Inflammatory osteolysis: A conspiracy against bone
Gabriel Mbalaviele, Deborah V. Novack, Georg Schett, Steven L. Teitelbaum
Journal of Clinical Investigation 2017
Understanding the Gut-Bone Signaling Axis
LR McCabe, N Parameswaran
Understanding the Gut-Bone Signaling Axis 2017
Brucella and Osteoarticular Cell Activation: Partners in Crime
GH Giambartolomei, PC Benitez, MV Delpino
Frontiers in microbiology 2017
TNF-α has both stimulatory and inhibitory effects on mouse monocyte-derived osteoclastogenesis
Y Cao, ID Jansen, S Sprangers, TJ de Vries, V Everts
Journal of Cellular Physiology 2017
Rapamycin promotes osteogenesis under inflammatory conditions
X Li, B Chang, B Wang, W Bu, L Zhao, J Liu, L Meng, L Wang, Y Xin, D Wang, Q Tang, C Zheng, H Sun
Molecular medicine reports 2017
C/EBPα transcription factor is regulated by the RANK cytoplasmic 535 IVVY 538 motif and stimulates osteoclastogenesis more strongly than c-Fos
J Jules, W Chen, X Feng, YP Li
The Journal of biological chemistry 2017
STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice: ROLE OF STING IN BONE FORMATION VIA DNA ACCRUAL
R Baum, S Sharma, JM Organ, C Jakobs, V Hornung, DB Burr, A Marshak-Rothstein, KA Fitzgerald, EM Gravallese
Arthritis & Rheumatology 2017
A Chemically Modified Curcumin (CMC 2.24) Inhibits Nuclear Factor κB Activation and Inflammatory Bone Loss in Murine Models of LPS-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis
MS Elburki, C Rossa, MR Guimarães-Stabili, HM Lee, FA Curylofo-Zotti, F Johnson, LM Golub
Inflammation 2017
TNFα Increases RANKL Expression via PGE2-Induced Activation of NFATc1
HJ Park, K Baek, JH Baek, HR Kim
International journal of molecular sciences 2017
Animal Models of Cancer-Associated Hypercalcemia
N Kohart, S Elshafae, J Breitbach, T Rosol
Veterinary Sciences 2017
Staphylococcal protein A promotes osteoclastogenesis through MAPK signaling during bone infection
Y Wang, X Liu, C Dou, Z Cao, C Liu, S Dong, J Fei
Journal of Cellular Physiology 2017
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner
Q Cong, H Jia, P Li, S Qiu, J Yeh, Y Wang, ZL Zhang, J Ao, B Li, H Liu
Scientific Reports 2017
RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors
Z Yao, W Lei, R Duan, Y Li, L Luo, BF Boyce
The Journal of biological chemistry 2017
Melittin inhibits osteoclast formation through the downregulation of the RANKL-RANK signaling pathway and the inhibition of interleukin-1β in murine macrophages
JY Choe, SK Kim
International journal of molecular medicine 2017
Cytokine induction of sol–gel-derived TiO2 and SiO2 coatings on metallic substrates after implantation to rat femur
W Urbanski, K Marycz, J Krzak, C Pezowicz, S Dragan
International Journal of Nanomedicine 2017
Pro-inflammatory Analysis of Macrophages in Contact with Titanium Particles and Porphyromonas gingivalis
CG Dodo, L Meirelles, A Aviles-Reyes, KG Ruiz, J Abranches, AA Cury
Brazilian Dental Journal 2017
Rheumatoid arthritis fibroblast-like synoviocytes co-cultured with PBMC increased peripheral CD4 + CXCR5 + ICOS + T cell numbers: CD4 + CXCR5 + ICOS + T cells were increased in FLS-PBMC co-culture system
Y Tang, B Wang, X Sun, H Li, X Ouyang, J Wei, B Dai, Y Zhang, X Li
Clinical & Experimental Immunology 2017
Dual neutralization of TNFR-2 and MMP-2 regulates the severity of S. aureus induced septic arthritis correlating alteration in the level of interferon gamma and interleukin-10 in terms of TNFR2 blocking
S Sultana, R Dey, B Bishayi
Immunologic Research 2017
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis
V Saferding, A Puchner, E Goncalves-Alves, M Hofmann, M Bonelli, JS Brunner, E Sahin, B Niederreiter, S Hayer, HP Kiener, E Einwallner, R Nehmar, R Carapito, P Georgel, MI Koenders, M Boldin, G Schabbauer, M Kurowska-Stolarska, G Steiner, JS Smolen, K Redlich, S Blüml
Journal of Autoimmunity 2017
Osteoblast Role in Rheumatic Diseases.
Corrado A, Maruotti N, Cantatore FP
International journal of molecular sciences 2017
Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.
Fischer CR, Mikami M, Minematsu H, Nizami S, Goo Lee H, Stamer D, Patel N, Yu Soung D, Back JH, Song L, Drissi H, Lee FY
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017
Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT
D Kawamoto, ES Ando-Suguimoto, B Bueno-Silva, JM DiRienzo, MP Mayer
Frontiers in Cellular and Infection Microbiology 2016
TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin
N Wang, Z Zhou, T Wu, W Liu, P Yin, C Pan, X Yu
Open Biology 2016
Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis
EY Karakas, A Yetisgin, D Cadirci, H Sezen, R Altunbas, F Kas, M Demir, T Ulas
Journal of Physical Therapy Science 2016
Osteoclasts—Key Players in Skeletal Health and Disease
DV Novack, G Mbalaviele, S Gordon
Microbiology spectrum 2016
A review of UHMWPE wear-induced osteolysis: the role for early detection of the immune response
AM Kandahari, X Yang, KA Laroche, AS Dighe, D Pan, Q Cui
Bone Research 2016
CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity
J Jules, W Chen, X Feng, YP Li
The Journal of biological chemistry 2016
Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis
J Yu, H Yun, B Shin, Y Kim, ES Park, S Choi, J Yu, DS Amarasekara, S Kim, J Inoue, MC Walsh, Y Choi, M Takami, J Rho
The Journal of biological chemistry 2016
Epigallocatechin-3-gallate protects against tumor necrosis factor alpha induced inhibition of osteogenesis of mesenchymal stem cells
W Liu, JB Fan, DW Xu, J Zhang, ZM Cui
Experimental biology and medicine (Maywood, N.J.) 2016
Dietary zinc deficiency induces oxidative stress and promotes tumor necrosis factor-α- and interleukin-1β-induced RANKL expression in rat bone
T Suzuki, S Katsumata, H Matsuzaki, K Suzuki
Journal of Clinical Biochemistry and Nutrition 2016
Compression and hypoxia play independent roles while having combinative effects in the osteoclastogenesis induced by periodontal ligament cells
ML Li, J Yi, Y Yang, X Zhang, W Zheng, Y Li, Z Zhao
The Angle Orthodontist 2016
Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways
C Mao, Y Wang, X Zhang, X Zheng, T Tang, E Lu
Cell Death and Disease 2016
ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β
A Robaszkiewicz, C Qu, E Wisnik, T Ploszaj, A Mirsaidi, FA Kunze, PJ Richards, P Cinelli, G Mbalaviele, MO Hottiger
Scientific Reports 2016
Calcium in Gluten-Free Life: Health-Related and Nutritional Implications
U Krupa-Kozak, N Drabińska
Foods 2016
Vaccination with recombinant RgpA peptide protects against Porphyromonas gingivalis -induced bone loss
A Wilensky, J Potempa, Y Houri-Haddad, L Shapira
Journal of Periodontal Research 2016
Lactobacillus reuteri 6475 Increases Bone Density in Intact Females Only under an Inflammatory Setting
FL Collins, R Irwin, H Bierhalter, J Schepper, RA Britton, N Parameswaran, LR McCabe, A Wijnen
PloS one 2016
Surgical Debridement Is Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model
JM Wagner, H Zöllner, C Wallner, B Ismer, J Schira, S Abraham, K Harati, M Lehnhardt, B Behr, MN Seleem
PloS one 2016
Osteoporosis and Periodontitis
CW Wang, LK McCauley
Current Osteoporosis Reports 2016
NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases.
Lin TH, Pajarinen J, Lu L, Nabeshima A, Cordova LA, Yao Z, Goodman SB
Advances in protein chemistry and structural biology 2016
The synovio-entheseal complex in enthesoarthritis
AD Cata, M Inglese, R Rubino, F Molinaro, G Mazzoccoli
Clinical and Experimental Medicine 2015
Inflammation and skeletal metastasis
H Roca, LK McCauley
BoneKEy Reports 2015
Bone and TNF in rheumatoid arthritis: clinical implications
M Manara, L Sinigaglia
RMD Open 2015
The obesity of bone
EA Greco, A Lenzi, S Migliaccio
Therapeutic Advances in Endocrinology and Metabolism 2015
Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
DS Amarasekara, J Yu, J Rho
Journal of Immunology Research 2015
TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression
Z Zhao, X Hou, X Yin, Y Li, R Duan, BF Boyce, Z Yao, J Tuukkanen
PloS one 2015
The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis
J Jules, S Wang, Z Shi, J Liu, S Wei, X Feng
The Journal of biological chemistry 2015
Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats
Hoi-Kei Lon, Debra C DuBois, Justin C Earp, Richard R Almon, William J Jusko
Pharmacology Research & Perspectives 2015
Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases
A Sabokbar, DJ Mahoney, F Hemingway, NA Athanasou
Clinical Reviews in Allergy & Immunology 2015
Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review
CH Alves, E Farrell, M Vis, EM Colin, E Lubberts
Clinical Reviews in Allergy & Immunology 2015
Contradictory role of CD97 in basal and tumor necrosis factor α-induced osteoclastogenesis in vivo: Role of CD97 in osteoclastogenesis and inflammation
HY Won, SH Mun, B Shin, SK Lee
Arthritis & Rheumatology 2015
Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts
R Baum, EM Gravallese
Clinical Reviews in Allergy & Immunology 2015
Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review
E Nevius, AC Gomes, JP Pereira
Clinical Reviews in Allergy & Immunology 2015
Mediators of inflammation and bone remodeling in rheumatic disease
AT Shaw, EM Gravallese
Seminars in Cell & Developmental Biology 2015
Bone-Immune Cell Crosstalk: Bone Diseases
G Mori, P D’Amelio, R Faccio, G Brunetti
Journal of Immunology Research 2015
Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations
BA Herbert, MS Valerio, M Gaestel, KL Kirkwood, Y Tintut
PloS one 2015
Circulating monocytes: an appropriate model for bone-related study
Y Zhou, HW Deng, H Shen
Osteoporosis International 2015
NF-κB decoy oligodeoxynucleotide inhibits wear particle-induced inflammation in a murine calvarial model: NF-κB ODN INHIBITS PARTICLE-INDUCED INFLAMMATION
T Sato, J Pajarinen, T Lin, Y Tamaki, F Loi, K Egashira, Z Yao, SB Goodman
Journal of biomedical materials research. Part A 2015
Interleukin-1 function and role in rheumatic disease
G Schett, JM Dayer, B Manger
Nature Reviews Rheumatology 2015
IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)
Z Chen, L Su, Q Xu, J Katz, SM Michalek, M Fan, X Feng, P Zhang
The Journal of biological chemistry 2015
Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-κB Ligand and Tumor Necrosis Factor Alpha Secretion
AI Viglietti, PC Benitez, MV Gentilini, LN Velásquez, CA Fossati, GH Giambartolomei, MV Delpino, SM Payne
Infection and immunity 2015
Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender.
Pivetta E, Wassermann B, Bulian P, Steffan A, Colombatti A, Polesel J, Spessotto P
Oncotarget 2015
SH3BP2 Cherubism Mutation Potentiates TNF-α-Induced Osteoclastogenesis via NFATc1 and TNF-α-Mediated Inflammatory Bone Loss: SH3BP2 CHERUBISM MUTATION POTENTIATES TNF-α-INDUCED OSTEOCLASTOGENESIS
T Mukai, S Ishida, R Ishikawa, T Yoshitaka, M Kittaka, R Gallant, YL Lin, R Rottapel, M Brotto, EJ Reichenberger, Y Ueki
Journal of Bone and Mineral Research 2014
RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
B Chen, W Wu, W Sun, Q Zhang, F Yan, Y Xiao
BioMed Research International 2014
Probiotics protect mice from ovariectomy-induced cortical bone loss
C Ohlsson, C Engdahl, F Fåk, A Andersson, SH Windahl, HH Farman, S Movérare-Skrtic, U Islander, K Sjögren
PloS one 2014
Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis
D Zhao, Z Shi, AH Warriner, P Qiao, H Hong, Y Wang, X Feng
PloS one 2014
Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis
SM Jung, KW Kim, CW Yang, SH Park, JH Ju
Journal of Immunology Research 2014
Chronic inflammation in biomaterial-induced periprosthetic osteolysis: NF-κB as a therapeutic target
T Lin, Y Tamaki, J Pajarinen, HA Waters, DK Woo, Z Yao, SB Goodman
Acta Biomaterialia 2014
Suppression of wear-particle-induced pro-inflammatory cytokine and chemokine production in macrophages via NF-κB decoy oligodeoxynucleotide: A preliminary report
T Lin, Z Yao, T Sato, M Keeney, C Li, J Pajarinen, F Yang, K Egashira, SB Goodman
Acta Biomaterialia 2014
Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement
SB Goodman, E Gibon, J Pajarinen, TH Lin, M Keeney, PG Ren, C Nich, Z Yao, K Egashira, F Yang, YT Konttinen
Journal of The Royal Society Interface 2014
Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss
DL Boyle, D Hammaker, M Edgar, MM Zaiss, S Teufel, JP David, G Schett, GS Firestein
PloS one 2014
MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption
Z He, J He, Z Liu, J Xu, SF Yi, H Liu, J Yang
Biochimie 2014
The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling
Z Zhang, L Xiang, D Bai, W Wang, Y Li, J Pan, H Liu, S Wang, G Xiao, D Ju
Nutrients 2014
Alternative pathways of osteoclastogenesis in inflammatory arthritis
IE Adamopoulos, ED Mellins
Nature Reviews Rheumatology 2014
The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model
HM Abuohashish, MM Ahmed, SS Al-Rejaie, KE Eltahir
Acta Pharmacologica Sinica 2014
Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-  and Interleukin-1  but Suppresses That by Interleukin-17A: IMPORTANCE OF PROTEOLYTIC DEGRADATION OF OSTEOPROTEGERIN BY LYSINE GINGIPAIN
T Akiyama, Y Miyamoto, K Yoshimura, A Yamada, M Takami, T Suzawa, M Hoshino, T Imamura, C Akiyama, R Yasuhara, K Mishima, T Maruyama, C Kohda, K Tanaka, J Potempa, H Yasuda, K Baba, R Kamijo
The Journal of biological chemistry 2014
Tumor cell p38 MAPK: A trigger of cancer bone osteolysis
Liu H, He J, Yang J
Cancer Cell & Microenvironment 2014
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow
E Ferreira, RM Porter, N Wehling, RP O'Sullivan, F Liu, A Boskey, DM Estok, MB Harris, MS Vrahas, CH Evans, JW Wells
The Journal of biological chemistry 2013
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
MN Weitzmann
Scientifica 2013
IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells
EM McCoy, H Hong, HC Pruitt, X Feng
BMC Cancer 2013
Calcineurin/NFAT pathway mediates wear particle-induced TNF-α release and osteoclastogenesis from mice bone marrow macrophages in vitro
F Liu, C Wu, Z Zhu, M Li, Y Mao, M Liu, X Wang, D Yu, T Tang
Acta Pharmacologica Sinica 2013
Impact of Inflammation on the Osteoblast in Rheumatic Diseases
R Baum, EM Gravallese
Current Osteoporosis Reports 2013
Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo
H Kitaura, K Kimura, M Ishida, H Kohara, M Yoshimatsu, T Takano-Yamamoto
Clinical & developmental immunology 2013
Osteoclasts: New Insights
F Xu, SL Teitelbaum
Bone Research 2013
Bone and vitamin D metabolism in HIV
A Panayiotopoulos, N Bhat, A Bhangoo
Reviews in Endocrine and Metabolic Disorders 2013
Mitogen-Activated Protein Kinases as Therapeutic Targets for Rheumatoid Arthritis
V Paunovic, MM Harnett
Drugs 2013
Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNFα therapy and discontinuation of glucocorticoids
KB Maresova, K Jarosova, K Pavelka, JJ Stepan
Rheumatology International 2013
Implanted bisphosphonates in bone cement affect bone markers in rat serum
T Mazurkiewicz, Ł Matuszewski, A Matuszewska, M Jaszek
International Orthopaedics 2013
The gut microbiota — masters of host development and physiology
F Sommer, F Bäckhed
Nature Reviews Microbiology 2013
Bone Mass and Mineral Metabolism Alterations in Adult Celiac Disease: Pathophysiology and Clinical Approach
MD Stefano, C Mengoli, M Bergonzi, G Corazza
Nutrients 2013
HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection
FE Carpio-Cano, RA Cadena, BE Sawaya
Journal of osteoporosis 2013
Effect of telmisartan on levels of IL-1, TNF-α, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model
AA Araújo, TO Souza, LM Moura, GA Brito, KS Aragão, LS Araújo, CA Medeiros, MS Alves, RF Araújo
Journal of Clinical Periodontology 2013
Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts.
Zupan J, Jeras M, Marc J
Biochemia Medica 2013
MicroRNA-181b regulates NF-κB downstream signaling and vascular inflammation
Xinghui Sun, Basak Icli, Akm Wara, Nathan Belkin, Shaolin He, Lester Kobzik, Gary Hunninghake, Miguel Pinilla Vera, Timothy Blackwell, Rebecca Baron, Mark W. Feinberg
Journal of Clinical Investigation 2012
IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner
CJ DeSelm, Y Takahata, J Warren, JC Chappel, T Khan, X Li, C Liu, Y Choi, YF Kim, W Zou, SL Teitelbaum
Journal of Cellular Biochemistry 2012
Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma
J Yang, J He, J Wang, Y Cao, J Ling, J Qian, Y Lu, H Li, Y Zheng, Y Lan, S Hong, J Matthews, MW Starbuck, NM Navone, RZ Orlowski, P Lin, LW Kwak, Q Yi
Leukemia 2012
The gut microbiota regulates bone mass in mice
K Sjögren, C Engdahl, P Henning, UH Lerner, V Tremaroli, MK Lagerquist, F Bäckhed, C Ohlsson
Journal of Bone and Mineral Research 2012
Bisphosphonates: effects on osteoblast
N Maruotti, A Corrado, A Neve, FP Cantatore
European Journal of Clinical Pharmacology 2012
The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis
ME Nadia, AS Nazrun, M Norazlina, NM Isa, M Norliza, SI Nirwana
Advances in pharmacological sciences 2012
Halofuginone prevents estrogen-deficient osteoporosis in mice
CJ DeSelm, W Zou, SL Teitelbaum
Journal of Cellular Biochemistry 2012
Immune Regulation of Osteoclast Function in Postmenopausal Osteoporosis: A Critical Interdisciplinary Perspective
R Zhao
International journal of medical sciences 2012
HIV: Inflammation and Bone
I Ofotokun, E McIntosh, MN Weitzmann
Current HIV/AIDS Reports 2012
Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis
J Jules, P Zhang, JW Ashley, S Wei, Z Shi, J Liu, SM Michalek, X Feng
The Journal of biological chemistry 2012
Macrophage-Specific TLR2 Signaling Mediates Pathogen-Induced TNF-Dependent Inflammatory Oral Bone Loss
G Papadopoulos, EO Weinberg, P Massari, FC Gibson, LM Wetzler, EF Morgan, CA Genco
Journal of immunology (Baltimore, Md. : 1950) 2012
Osteoporosis in chronic inflammatory disease: the role of malnutrition
T Montalcini, S Romeo, Y Ferro, V Migliaccio, C Gazzaruso, A Pujia
Endocrine 2012
The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues
J Zupan, R Komadina, J Marc
Journal of Biomedical Science 2012
Time of progression to osteopenia/osteoporosis in chronically HIV-infected patients: screening DXA scan
E Negredo, A Bonjoch, M Gómez-Mateu, C Estany, J Puig, N Perez-Alvarez, J Rosales, S Gregorio, L Rio, G Gómez, B Clotet
PloS one 2012
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer and infection
Dallas Jones, Laurie Glimcher, Antonios Aliprantis
Journal of Clinical Investigation 2011
Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis
J Cheng, J Liu, Z Shi, D Xu, S Luo, GP Siegal, X Feng, S Wei
Journal of Cellular Biochemistry 2011
Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss
DT Graves, J Li, DL Cochran
Journal of dental research 2011
Genetic responses to nanostructured calcium-phosphate-coated implants
R Jimbo, Y Xue, M Hayashi, HO Schwartz-Filho, M Andersson, K Mustafa, A Wennerberg
Journal of dental research 2011
Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
T Braun, J Zwerina
Arthritis Research & Therapy 2011
Interactions between the immune system and bone
P D'Amelio, G Fornelli, I Roato, GC Isaia
World Journal of Orthopedics 2011
Why TNF-α inhibition is not sufficient to avoid juxta-articular erosions in chronic arthritis?
N Maruotti, F dOnofrio, A Corrado, FP Cantatore
Internal and Emergency Medicine 2011
Secondary osteoporosis in patients with juvenile idiopathic arthritis
KB Maresova
Journal of osteoporosis 2011
Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification
G Verbruggen, R Wittoek, BV Cruyssen, D Elewaut
Annals of the rheumatic diseases 2011
The Critical Role of IL-34 in Osteoclastogenesis
Z Chen, K Buki, J Vääräniemi, G Gu, HK Väänänen
PloS one 2011
Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8
LB Ivashkiv, B Zhao, KH Park-Min, M Takami
Annals of the New York Academy of Sciences 2011
IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis
JE Otero, S Dai, MA Alhawagri, I Darwech, Y Abu-Amer
Journal of Bone and Mineral Research 2010
THE IMMUNE SYSTEM AND BONE
R Pacifici
Archives of Biochemistry and Biophysics 2010
Role of NF-κB in the skeleton
DV Novack
Cell Research 2010
Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention
S Karmakar, J Kay, EM Gravallese
Rheumatic diseases clinics of North America 2010
Control of RANKL gene expression
CA O'Brien
Bone 2010
Osteoclastogenesis and arthritis
N Maruotti, M Grano, S Colucci, F dOnofrio, FP Cantatore
Clinical and Experimental Medicine 2010
Fracture-Associated Hospitalizations in Patients with Inflammatory Bowel Disease
AN Ananthakrishnan, EL McGinley, DG Binion, K Saeian
Digestive Diseases and Sciences 2010
Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model
S García, J Forteza, C López-Otin, JJ Gómez-Reino, A González, C Conde
Arthritis Research & Therapy 2010
Protective role of osteopontin in endodontic infection
SR Rittling, C Zetterberg, K Yagiz, S Skinner, N Suzuki, A Fujimura, H Sasaki
Immunology 2010
Effects and mechanism of aromatic aminoketone SY0916 on osteoclastic bone destruction
L Wang, S Peng, Y Liu, P Li, W Wang
Acta Pharmacologica Sinica 2010
Vitamin D and Bone Health; Potential Mechanisms
E Laird, M Ward, E McSorley, JJ Strain, J Wallace
Nutrients 2010
Direct Inhibition of Human RANK + Osteoclast Precursors Identifies a Homeostatic Function of IL-1β
B Lee, TH Kim, JB Jun, DH Yoo, JH Woo, SJ Choi, YH Lee, GG Song, J Sohn, KH Park-Min, LB Ivashkiv, JD Ji
Journal of immunology (Baltimore, Md. : 1950) 2010
Association of periodontitis with rheumatoid arthritis and atherosclerosis: Novel paradigms in etiopathogeneses and management?
Soory M
Open Access Rheumatology : Research and Reviews 2010
NF-kappaB2p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Zhenqiang Yao, Lianping Xing, Brendan Boyce
Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss
J Goswami, N Hernández-Santos, LA Zuniga, SL Gaffen
European Journal of Immunology 2009
Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis
NB Binder, B Niederreiter, O Hoffmann, R Stange, T Pap, TM Stulnig, M Mack, RG Erben, JS Smolen, K Redlich
Nature Medicine 2009
The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction
S Ishida, S Yamane, S Nakano, T Yanagimoto, Y Hanamoto, M Maeda-Tanimura, T Toyosaki-Maeda, J Ishizaki, Y Matsuo, N Fukui, T Itoh, T Ochi, R Suzuki
Immunology 2009
Promising bone-related therapeutic targets for rheumatoid arthritis
Y Choi, JR Arron, MJ Townsend
Nature Reviews Rheumatology 2009
Lipopolysaccharide-induced osteoclastogenesis from mononuclear precursors: a mechanism for osteolysis in chronic otitis
R Nason, JY Jung, RA Chole
Journal of the Association for Research in Otolaryngology 2009
Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis
K Nozawa, M Fujishiro, M Kawasaki, H Kaneko, K Iwabuchi, M Yanagida, F Suzuki, K Miyazawa, Y Takasaki, H Ogawa, K Takamori, I Sekigawa
Arthritis Research & Therapy 2009
The effect of risedronate treatment on serum cytokines in postmenopausal osteoporosis: a 6-month randomized and controlled study
U Dundar, V Kavuncu, IH Ciftci, D Evcik, O Solak, T Cakir
Journal of Bone and Mineral Metabolism 2009
Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells
YR Park, JS Eun, HJ Choi, M Nepal, DK Kim, SY Seo, R Li, WS Moon, NP Cho, SD Cho, TS Bae, BI Kim, Y Soh
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFalpha or anti-IL-1 therapies
M Stolina, G Schett, D Dwyer, S Vonderfecht, S Middleton, D Duryea, E Pacheco, G Van, B Bolon, U Feige, D Zack, P Kostenuik
Arthritis Research & Therapy 2009
Expansion of CD14+CD16+ peripheral monocytes among patients with aseptic loosening
W Wu, X Zhang, C Zhang, T Tang, W Ren, K Dai
Inflammation Research 2009
Interleukin-1 Polymorphisms in Relation to External Apical Root Resorption (EARR)
N Gülden, T Eggermann, K Zerres, M Beer, A Meinelt, P Diedrich
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie 2009
Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets
S Wei, GP Siegal
Pathology - Research and Practice 2008
NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis
Y Yamanaka, W Abu-Amer, D Foglia, J Otero, JC Clohisy, Y Abu-Amer
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008
Osteoimmunology: interactions of the bone and immune system
J Lorenzo, M Horowitz, Y Choi
Endocrine reviews 2008
HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE
Z Zhou, JY Han, CX Xi, JX Xie, X Feng, CY Wang, L Mei, WC Xiong
Journal of Bone and Mineral Research 2008
Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts
S Bai, J Zha, H Zhao, FP Ross, SL Teitelbaum
The Journal of biological chemistry 2008
The Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis
M Stolina, B Bolon, S Middleton, D Dwyer, H Brown, D Duryea, L Zhu, A Rohner, J Pretorius, P Kostenuik, U Feige, D Zack
Journal of Clinical Immunology 2008
Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo
AH Mian, H Saito, N Alles, H Shimokawa, K Aoki, K Ohya
Journal of Bone and Mineral Metabolism 2008
VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism
Q Zhang, R Guo, Y Lu, L Zhao, Q Zhou, EM Schwarz, J Huang, D Chen, ZG Jin, BF Boyce, L Xing
The Journal of biological chemistry 2008
Polymethylmethacrylate particles stimulate bone resorption of mature osteoclasts in vitro
H Zhang, BF Ricciardi, X Yang, Y Shi, NP Camacho, MG Bostrom
Acta Orthopaedica 2008
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism
Z Yao, L Xing, C Qin, EM Schwarz, BF Boyce
The Journal of biological chemistry 2008
Highly Conserved Surface Proteins of Oral Spirochetes as Adhesins and Potent Inducers of Proinflammatory and Osteoclastogenic Factors
HK Jun, YM Kang, HR Lee, SH Lee, BK Choi
Infection and immunity 2008
Osteoimmunology: cytokines and the skeletal system
Lee SH, Kim TS, Choi Y, Lorenzo J
BMB Reports 2008
TNF-induced structural joint damage is mediated by IL-1
J Zwerina, K Redlich, K Polzer, L Joosten, G Krönke, J Distler, A Hess, N Pundt, T Pap, O Hoffmann, J Gasser, C Scheinecker, JS Smolen, W Berg, G Schett
Proceedings of the National Academy of Sciences 2007
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
AE Kearns, S Khosla, PJ Kostenuik
Endocrine reviews 2007
Mesenchymal stromal cells. Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis
T Ochi, H Yoshikawa, T Toyosaki-Maeda, PE Lipsky
Arthritis Research & Therapy 2007
Osteoclasts: What Do They Do and How Do They Do It?
SL Teitelbaum
The American Journal of Pathology 2007
Joint remodelling in inflammatory disease
G Schett
Annals of the rheumatic diseases 2007
Cells of the synovium in rheumatoid arthritis. Osteoclasts
G Schett
Arthritis Research & Therapy 2007
Knochenstoffwechsel: Molekulare Mechanismen
E Neumann, G Schett
Zeitschrift für Rheumatologie 2007
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer:
T King, A Vardanyan, L Majuta, O Melemedjian, R Nagle, AE Cress, TW Vanderah, J Lai, F Porreca
PAIN 2007
How Does Joint Remodeling Work?: New Insights in the Molecular Regulation of the Architecture of Joints
Schett G
Cell adhesion & migration 2007
Glucocorticoids suppress bone formation via the osteoclast
Hyun-Ju Kim, Haibo Zhao, Hideki Kitaura, Sandip Bhattacharyya, Judson A. Brewer, Louis J. Muglia, F. Patrick Ross, Steven L. Teitelbaum
Journal of Clinical Investigation 2006
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
Dailing Mao, Holly Epple, Brian Uthgenannt, Deborah V. Novack, Roberta Faccio
Journal of Clinical Investigation 2006
B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease
T Kawai, T Matsuyama, Y Hosokawa, S Makihira, M Seki, NY Karimbux, RB Goncalves, P Valverde, S Dibart, YP Li, LA Miranda, CW Ernst, Y Izumi, MA Taubman
The American Journal of Pathology 2006
Estrogen deficiency and bone loss: an inflammatory tale
MN Weitzmann, R Pacifici
Journal of Clinical Investigation 2006
Modulation of osteoclastogenesis induced by nucleoside reverse transcriptase inhibitors
G Pan, M Kilby, JM McDonald
AIDS Research and Human Retroviruses 2006
Peripheral cannabinoid receptor, CB2, regulates bone mass
O Ofek, M Karsak, N Leclerc, M Fogel, B Frenkel, K Wright, J Tam, M Attar-Namdar, V Kram, E Shohami, R Mechoulam, A Zimmer, I Bab
Proceedings of the National Academy of Sciences 2006
Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS
G Pan, Z Yang, SW Ballinger, JM McDonald
Annals of the New York Academy of Sciences 2006
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
C Sutton, C Brereton, B Keogh, KH Mills, EC Lavelle
Journal of Experimental Medicine 2006
The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction
GP Garlet, CR Cardoso, AP Campanelli, BR Ferreira, MJ Avila-Campos, FQ Cunha, JS Silva
Clinical & Experimental Immunology 2006
M-CSF mediates TNF-induced inflammatory osteolysis
Hideki Kitaura, Ping Zhou, Deborah V. Novack, F. Patrick Ross, Steven L. Teitelbaum
Journal of Clinical Investigation 2005
Role of the immune system in postmenopausal bone loss
MN Weitzmann, R Pacifici
Current Osteoporosis Reports 2005
Osteoporosis, inflammation and ageing
L Ginaldi, MC Benedetto, MD Martinis
Immunity & Ageing 2005
Osteoclasts; culprits in inflammatory osteolysis
SL Teitelbaum
Arthritis Research & Therapy 2005
Central IL-1 receptor signaling regulates bone growth and mass
A Bajayo, I Goshen, S Feldman, V Csernus, K Iverfeldt, E Shohami, R Yirmiya, I Bab
Proceedings of the National Academy of Sciences 2005
Chronic inflammatory intestinal diseases and bone loss.
Bardella MT, Bianchi ML, Teti A
Gut 2005

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