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Citations to this article

Role of osteopontin in amplification and perpetuation of rheumatoid synovitis
Guangwu Xu, … , Jian Hong, Jingwu Z. Zhang
Guangwu Xu, … , Jian Hong, Jingwu Z. Zhang
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):1060-1067. https://doi.org/10.1172/JCI23273.
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Article Autoimmunity Article has an altmetric score of 3

Role of osteopontin in amplification and perpetuation of rheumatoid synovitis

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Abstract

Osteopontin (OPN) is an extracellular matrix protein of pleiotropic properties and has been recently recognized as a potential inflammatory cytokine. In this study, we demonstrate, for the first time to our knowledge, that overexpression of OPN in synovial T cells is associated with local inflammatory milieu and that OPN acts as an important mediator in amplification and perpetuation of rheumatoid synovitis. The study revealed that mRNA expression of OPN was highly elevated in CD4+ synovial T cells derived from patients with RA, which correlated with increased OPN concentrations in synovial fluid (SF). The pattern of OPN overexpression was confined to rheumatoid synovium and correlated with coexpression of selected OPN receptors in synovial T cells, including integrins αv and β1 and CD44. RA-derived SF stimulated the expression of OPN in T cells, which was attributable to IL-10 present in SF and abrogated by anti–IL-10 antibody. Among the more than 300 autoimmune and inflammatory response genes examined, OPN selectively induced the expression of proinflammatory cytokines and chemokines known to promote migration and recruitment of inflammatory cells. Furthermore, it was evident that OPN activated transcription factor NF-κB in mononuclear cells. The study has important implications for understanding the role of OPN in rheumatoid synovitis and other inflammatory conditions.

Authors

Guangwu Xu, Hong Nie, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, Jingwu Z. Zhang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 1 3 2 1 1 2 1 2 7 1 4 5 2 6 6 1 2 3 1 52
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (6)

Title and authors Publication Year
The impact of the extracellular matrix on inflammation
L Sorokin
Nature Reviews Immunology 2010
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance
FW Kiefer, M Zeyda, K Gollinger, B Pfau, A Neuhofer, T Weichhart, MD Säemann, R Geyeregger, M Schlederer, L Kenner, TM Stulnig
Diabetes 2010
Genetic associations in type I interferon related pathways with autoimmunity
AM Delgado-Vega, ME Alarcón-Riquelme, SV Kozyrev
Arthritis Research & Therapy 2010
Osteopontin Mediates Citrobacter rodentium-Induced Colonic Epithelial Cell Hyperplasia and Attaching-Effacing Lesions
E Wine, G Shen-Tu, MG Gareau, HA Goldberg, C Licht, BY Ngan, ES Sorensen, J Greenaway, J Sodek, R Zohar, PM Sherman
The American Journal of Pathology 2010
The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitis: OPN and CC10 expression in allergic rhinitis
Y Liu, X Lu, HJ Yu, XY Hua, YH Cui, SK Huang, Z Liu
Clinical & Experimental Allergy 2010
Osteopontin: An Effector and an Effect of Tumor Metastasis
L Shevde, S Das, D Clark, R Samant
Current molecular medicine 2010

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