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Usage Information

Qa-1 restriction of CD8+ suppressor T cells
Stefanie Sarantopoulos, … , Linrong Lu, Harvey Cantor
Stefanie Sarantopoulos, … , Linrong Lu, Harvey Cantor
Published November 1, 2004
Citation Information: J Clin Invest. 2004;114(9):1218-1221. https://doi.org/10.1172/JCI23152.
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Review Series

Qa-1 restriction of CD8+ suppressor T cells

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Abstract

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25+CD4+ T cells, and a subpopulation of CD8+ T cells. Animal model studies of multiple sclerosis have suggested an important role for suppressor CD8+ T cells in protection against disease recurrence and exacerbation. The molecular lynchpin of CD8+ suppressive activity is the murine MHC molecule Qa-1, termed HLA-E in humans. Here we summarize findings from work on Qa-1 that have begun to delineate suppressor CD8+ T cells and their mechanisms of action in the context of self tolerance and autoimmune disease.

Authors

Stefanie Sarantopoulos, Linrong Lu, Harvey Cantor

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,020 148
PDF 86 20
Figure 118 2
Citation downloads 93 0
Totals 1,317 170
Total Views 1,487
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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