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Mark R. Duranski, … , Mark T. Gladwin, David J. Lefer
Published May 2, 2005
Citation Information: J Clin Invest. 2005;115(5):1232-1240. https://doi.org/10.1172/JCI22493.
Citation Information: J Clin Invest. 2005;115(5):1232-1240. https://doi.org/10.1172/JCI22493.
Abstract
Nitrite represents a circulating and tissue storage form of NO whose bioactivation is mediated by the enzymatic action of xanthine oxidoreductase, nonenzymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins. Because the rate of NO generation from nitrite is linearly dependent on reductions in oxygen and pH levels, we hypothesized that nitrite would be reduced to NO in ischemic tissue and exert NO-dependent protective effects. Solutions of sodium nitrite were administered in the setting of hepatic and cardiac ischemia-reperfusion (I/R) injury in mice. In hepatic I/R, nitrite exerted profound dose-dependent protective effects on cellular necrosis and apoptosis, with highly significant protective effects observed at near-physiological nitrite concentrations. In myocardial I/R injury, nitrite reduced cardiac infarct size by 67%. Consistent with hypoxia-dependent nitrite bioactivation, nitrite was reduced to NO, S-nitrosothiols, N-nitros-amines, and iron-nitrosylated heme proteins within 1–30 minutes of reperfusion. Nitrite-mediated protection of both the liver and the heart was dependent on NO generation and independent of eNOS and heme oxygenase-1 enzyme activities. These results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury. These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states.
Authors
Mark R. Duranski, James J.M. Greer, Andre Dejam, Sathya Jaganmohan, Neil Hogg, William Langston, Rakesh P. Patel, Shaw-Fang Yet, Xunde Wang, Christopher G. Kevil, Mark T. Gladwin, David J. Lefer
Total citations by year
Citation information
Citations to this article (281)
| Title and authors | Publication | Year |
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Antioxidants | 2025 |
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The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming
Grimmett ZW, Zhang R, Zhou HL, Chen Q, Miller D, Qian Z, Lin J, Kalra R, Gross SS, Koch WJ, Premont RT, Stamler JS |
bioRxiv | 2025 |
|
Regulation of mammalian cellular metabolism by endogenous cyanide production
Zuhra K, Petrosino M, Janickova L, Petric J, Ascenção K, Vignane T, Khalaf M, Philipp TM, Ravani S, Anand A, Martins V, Santos S, Erdemir S, Malkondu S, Sitek B, Kelestemur T, Kieronska-Rudek A, Majtan T, Filgueira L, Maric D, Chlopicki S, Hoogewijs D, Haskó G, Papapetropoulos A, Logue BA, Boss GR, Filipovic MR, Szabo C |
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|
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Lee KH, Song MY, Lee S, Park J, Kang JH, Cho H, Kim KB, Son SJ, Cheng XW, Lee YJ, Lee GJ, Shin JH, Kim W |
PloS one | 2024 |
|
Seven-day dietary nitrate supplementation clinically significantly improves basal macrovascular function in postmenopausal women: a randomized, placebo-controlled, double-blind, crossover clinical trial
Delgado Spicuzza JM, Gosalia J, Zhong L, Bondonno C, Petersen KS, De Souza MJ, Alipour E, Kim-Shapiro DB, Somani YB, Proctor DN |
Frontiers in Nutrition | 2024 |
|
NaHS protects brain, heart, and lungs as remote organs from renal ischemia/reperfusion-induced oxidative stress in male and female rats.
Saberi S, Najafipour H, Rajizadeh MA, Etminan A, Jafari E, Iranpour M |
BMC nephrology | 2024 |
|
The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial.
Rathod KS, Mathur A, Shabbir A, Khambata RS, Lau C, Beirne AM, Chhetri I, Ono M, Belgaid DR, Massimo G, Ramasamy A, Tufaro V, Jain AK, Poulter N, Falaschetti E, Jones DA, Garcia-Garcia HM, Bourantas C, Learoyd A, Warren HR, Ahluwalia A |
EClinicalMedicine | 2024 |
|
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Ferdinandy P, Andreadou I, Baxter GF, Bøtker HE, Davidson SM, Dobrev D, Gersh BJ, Heusch G, Lecour S, Ruiz-Meana M, Zuurbier CJ, Hausenloy DJ, Schulz R |
Pharmacological reviews | 2023 |
|
Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model
LaPenna KB, Li Z, Doiron JE, Sharp TE III, Xia H, Moles K, Koul K, Wang JS, Polhemus DJ, Goodchild TT, Patel RB, Shah SJ, Lefer DJ |
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|
Bringing Nitric Oxide to the Molybdenum World—A Personal Perspective
Maia LB |
Molecules (Basel, Switzerland) | 2023 |
|
Nanomedicine‐Based Therapeutics for Myocardial Ischemic/Reperfusion Injury
Li X, Ou W, Xie M, Yang J, Li Q, Li T |
Advanced Healthcare Materials | 2023 |
|
Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?
Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, Matavulj A, Djuric DM |
Biomolecules | 2022 |
|
Ultrasound-Induced Destruction of Nitric Oxide–Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury
Liang Z, Chen H, Gong X, Shi B, Lin L, Tao F, Wu Q, Fang M, Li H, Lu C, Xu H, Zhao Y, Chen B |
Frontiers in pharmacology | 2022 |
|
Mechanistic Insights into Inorganic Nitrite-Mediated Vasodilation of Isolated Aortic Rings under Oxidative/Hypertensive Conditions and S-Nitros(yl)ation of Proteins in Germ-Free Mice.
Stamm P, Kalinovic S, Oelze M, Steven S, Czarnowski A, Kvandova M, Bayer F, Reinhardt C, Münzel T, Daiber A |
Biomedicines | 2022 |
|
Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury.
Mu J, Li C, Shi Y, Liu G, Zou J, Zhang DY, Jiang C, Wang X, He L, Huang P, Yin Y, Chen X |
Nature Communications | 2022 |
|
Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration
Katz-Brull R |
Biology | 2022 |
|
Soluble guanylate cyclase (sGC) stimulator vericiguat alleviates myocardial ischemia-reperfusion injury by improving microcirculation.
Cai Y, Zhang B, Shalamu A, Gao T, Ge J |
Annals of translational medicine | 2022 |
|
Changes in Some Vascular Biomarkers in Patients with Severe COVID-19 with Various Degrees of Pulmonary Hypertension.
Shilin DS, Shapovalov KG |
Bulletin of Experimental Biology and Medicine | 2022 |
|
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial
Gao J, Cheng Z, Jiang S, Wills M, Wehbe A, Rajah GB, Geng X, Ding Y |
BMC geriatrics | 2022 |
|
The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease.
Huang X, Zeng Z, Li S, Xie Y, Tong X |
Pharmaceutics | 2022 |
|
The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management.
Maiuolo J, Oppedisano F, Carresi C, Gliozzi M, Musolino V, Macrì R, Scarano F, Coppoletta A, Cardamone A, Bosco F, Mollace R, Muscoli C, Palma E, Mollace V |
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|
Photobiomodulation and nitric oxide signaling.
Kashiwagi S, Morita A, Yokomizo S, Ogawa E, Komai E, Huang PL, Bragin DE, Atochin DN |
2022 | |
|
Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney
G Zhang, H Han, Z Zhuge, F Dong, S Jiang, W Wang, DD Guimarães, TA Schiffer, EY Lai, LR Carvalho, RB Lucena, VA Braga, E Weitzberg, JO Lundberg, M Carlstrom |
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|
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M Filice, MC Cerra, S Imbrogno |
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|
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L Cai, G Rajah, H Duan, J Gao, Z Cheng, R Xin, S Jiang, P Palmer, X Geng, Y Ding |
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|
Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO
SE Lewis, CB Rosencrance, ED Vallance, A Giromini, XM Williams, JY Oh, H Schmidt, AC Straub, PD Chantler, RP Patel, EE Kelley |
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|
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M Buelna-Chontal, WR García-Niño, A Silva-Palacios, C Enríquez-Cortina, C Zazueta |
Antioxidants | 2021 |
|
Supplemental nitrite increases choroidal neovascularization in mice
X Qi, K Ricart, KA Ahmed, RP Patel, ME Boulton |
Nitric Oxide | 2021 |
|
Safety and toxicology assessment of sodium nitrite administered by intramuscular injection
L Miller, CD Hébert, SD Grimes, JS Toomey, JY Oh, JJ Rose, RP Patel |
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|
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British Journal of Anaesthesia | 2021 |
|
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S Li, H Jin, G Sun, C Zhang, J Wang, H Xu, D Zhang, S Wang |
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|
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|
Protective Effects of Topical Application of Nitrite on Testicular Ischemia-Reperfusion Injury in Rats.
Lee JW, Hwang ET, Han JS |
Oxidative medicine and cellular longevity | 2021 |
|
Effect on health from consumption of meat and meat products.
Lee DY, Lee SY, Jo C, Yoon Y, Jeong JY, Hur SJ |
Journal of Animal Science and Technology | 2021 |
|
Effects of chronic dietary nitrate supplementation on longevity, vascular function and cancer incidence in rats.
Carvalho LRRA, Guimarães DD, Flôr AFL, Leite EG, Ruiz CR, de Andrade JT, Monteiro MMO, Balarini CM, Lucena RB, Sandrim VC, Lundberg JO, Weitzberg E, Carlström M, Braga VA |
Redox Biology | 2021 |
|
Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest
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|
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|
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S Wu, MH Zou |
International journal of molecular sciences | 2020 |
|
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LE Almeida, S Kamimura, CM de Souza Batista, N Spornick, MY Nettleton, E Walek, ML Smith, JC Finkel, DS Darbari, P Wakim, ZM Quezado |
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|
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|
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KA Ahmed, K Kim, K Ricart, WV Pol, X Qi, MM Bamman, C Behrens, G Fisher, ME Boulton, C Morrow, PV ONeal, RP Patel |
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|
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|
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GZ Yu, F Istvanic, X Chen, M Nouraie, S Shiva, AC Straub, JJ Pacella |
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|
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A Kumar, K Noda, B Philips, M Velayutham, DB Stolz, MT Gladwin, S Shiva, J DCunha |
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|
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KM Shestakova, NE Moskaleva, NV Mesonzhnik, AV Kukharenko, IV Serkov, II Lyubimov, EV Fomina-Ageeva, VV Bezuglov, MG Akimov, SA Appolonova |
Molecules (Basel, Switzerland) | 2020 |
|
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K Quesnelle, DA Guimaraes, K Rao, AB Singh, Y Wang, N Hogg, S Shiva |
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|
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Reina S, Pittalà MGG, Guarino F, Messina A, De Pinto V, Foti S, Saletti R |
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|
Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19.
Yamasaki H |
2020 | |
|
Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies
RO Soares, DM Losada, MC Jordani, P Évora, O Castro-e-Silva |
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|
Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest
T Uray, PE Empey, T Drabek, JP Stezoski, K Janesko-Feldman, T Jackson, RH Garman, F Kim, PM Kochanek, C Dezfulian |
Nitric Oxide | 2019 |
|
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M Ntessalen, NE Procter, K Schwarz, BL Loudon, M Minnion, BO Fernandez, VS Vassiliou, D Vauzour, M Madhani, D ConstantinTeodosiu, JD Horowitz, M Feelisch, D Dawson, PG Crichton, MP Frenneaux |
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|
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|
Comparison of electrochemical nitric oxide detection methods with chemiluminescence for measuring nitrite concentration in food samples.
Gill A, Zajda J, Meyerhoff ME |
Analytica Chimica Acta | 2019 |
|
Nitric oxide signalling in cardiovascular health and disease
C Farah, LY Michel, JL Balligand |
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|
Hemodynamic effects of IV sodium nitrite in hospitalized comatose survivors of out of hospital cardiac arrest
C Dezfulian, M Olsufka, D Fly, S Scruggs, R Do, C Maynard, G Nichol, F Kim |
Resuscitation | 2018 |
|
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LB Maia, JJ Moura |
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|
cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
M Park, P Sandner, T Krieg |
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|
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DM Yellon, Z He, R Khambata, A Ahluwalia, SM Davidson |
Basic Research in Cardiology | 2018 |
|
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A Panisello-Roselló, A Lopez, E Folch-Puy, T Carbonell, A Rolo, C Palmeira, R Adam, M Net, J Roselló-Catafau |
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|
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|
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DD Thomas, C Corey, J Hickok, Y Wang, S Shiva |
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|
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British Journal of Pharmacology | 2018 |
|
Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury.
Lee JW, Lee DH, Park JK, Han JS |
Asian Journal of Andrology | 2018 |
|
Usefulness of Intravenous Sodium Nitrite During Resuscitation for the Treatment of Out-of-Hospital Cardiac Arrest.
Kim F, Dezfulian C, Empey PE, Morrell M, Olsufka M, Scruggs S, Kudenchuk P, May S, Maynard C, Sayre MR, Nichol G |
The American Journal of Cardiology | 2018 |
|
Nitric oxide metabolites in hypoxia, freezing, and hibernation of the wood frog, Rana sylvatica.
Williams BL, Wiebler JM, Lee RE Jr, Costanzo JP |
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology | 2018 |
|
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D Palevski, LP LevinKotler, D Kain, N NaftaliShani, N Landa, T BenMordechai, T Konfino, R Holbova, N Molotski, R RosinArbesfeld, RA Lang, J Leor |
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|
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JO Ormerod, JD Evans, H Contractor, M Beretta, S Arif, BO Fernandez, M Feelisch, B Mayer, RK Kharbanda, MP Frenneaux, H Ashrafian |
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|
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G Caruso, CG Fresta, F Martinez-Becerra, L Antonio, RT Johnson, RP de Campos, JM Siegel, MB Wijesinghe, G Lazzarino, SM Lunte |
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|
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|
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|
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S Steven, A Daiber, JF Dopheide, T Münzel, C Espinola-Klein |
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|
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P Cabrales, S Caroen, A Oronsky, C Carter, J Trepel, T Summers, T Reid, N Oronsky, M Lybeck, B Oronsky |
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|
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Redox Biology | 2017 |
|
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DQ Le, AE Kuriakose, DX Nguyen, KT Nguyen, S Acharya |
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|
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R Kawaguchi, N Hirata, Y Tokinaga, S Hayashi, S Inoue, N Watanabe, M Yamakage |
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|
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Phillip Bystrom, Nicole Foley, Luis Toledo-Pereyra, Kelly Quesnelle |
EXCLI J | 2017 |
|
Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels.
Otis JP, Pike AC, Torrealba JR, Carey HV |
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|
Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice.
Wang Y, Song X, Yue X, Su H, Gu Y, Bowman L, Ding M, Zou B, Zhao J, Lin X |
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|
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K Fukazawa, JD Lang |
World journal of hepatology | 2016 |
|
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|
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|
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E Donnarumma, S Bhushan, JM Bradley, H Otsuka, EL Donnelly, DJ Lefer, KN Islam |
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|
Nitric oxide treatments as adjuncts to reperfusion in acute myocardial infarction: a systematic review of experimental and clinical studies
JS Bice, BR Jones, GR Chamberlain, GF Baxter |
Basic Research in Cardiology | 2016 |
|
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Y Liu, DG Buerk, KA Barbee, D Jaron |
Nitric Oxide | 2016 |
|
The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose
N Wajih, X Liu, P Shetty, S Basu, H Wu, N Hogg, RP Patel, CM Furdui, DB Kim-Shapiro |
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|
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SV Ibba, MA Ghonim, K Pyakurel, MR Lammi, A Mishra, AH Boulares |
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|
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A Ahluwalia, M Gladwin, GD Coleman, N Hord, G Howard, DB KimShapiro, M Lajous, FJ Larsen, DJ Lefer, LA McClure, BT Nolan, R Pluta, A Schechter, CY Wang, MH Ward, JL Harman |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2016 |
|
Inflammation Activation Contributes to Adipokine Imbalance in Patients with Acute Coronary Syndrome
R Li, L Chen, S Zhao, X Huang, HB Tanowitz |
PloS one | 2016 |
|
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
CD Koch, MT Gladwin, BA Freeman, JO Lundberg, E Weitzberg, A Morris |
Free radical biology & medicine | 2016 |
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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JBIC Journal of Biological Inorganic Chemistry | 2015 |
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Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver
B Björnsson |
World journal of gastroenterology : WJG | 2015 |
|
Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice
T Fukuda, M Kakinohana, C Takayama, M Matsushita, K Sugahara |
Journal of Anesthesia | 2015 |
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Effect of Sodium Nitrite on Ischaemia and Reperfusion-Induced Arrhythmias in Anaesthetized Dogs: Is Protein S-Nitrosylation Involved?
M Kovács, A Kiss, M Gönczi, G Miskolczi, G Seprényi, J Kaszaki, MJ Kohr, E Murphy, Á Végh, B Rodriguez |
PloS one | 2015 |
|
Nitric oxide in liver diseases
Y Iwakiri, MY Kim |
Trends in Pharmacological Sciences | 2015 |
|
NO-Rich Diet for Lifestyle-Related Diseases
J Kobayashi, K Ohtake, H Uchida |
Nutrients | 2015 |
|
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome
DJ Polhemus, JM Bradley, KN Islam, LP Brewster, JW Calvert, YX Tao, CC Chang, II Pipinos, TT Goodchild, DJ Lefer |
American journal of physiology. Heart and circulatory physiology | 2015 |
|
Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride
DA Vitturi, L Minarrieta, SR Salvatore, EM Postlethwait, M Fazzari, G Ferrer-Sueta, JR Lancaster, BA Freeman, FJ Schopfer |
Nature Chemical Biology | 2015 |
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Dietary nitrate reduces the O2 cost of desert marching but elevates the rise in core temperature
M Kuennen, L Jansen, T Gillum, J Granados, W Castillo, A Nabiyar, K Christmas |
European Journal of Applied Physiology | 2015 |
|
Protective effect of exogenous nitrite in postoperative ileus: Protective effect of nitrite in POI
SM Cosyns, S Shiva, RA Lefebvre |
British Journal of Pharmacology | 2015 |
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Inhaled, nebulized sodium nitrite protects in murine and porcine experimental models of hemorrhagic shock and resuscitation by limiting mitochondrial injury
B Kautza, H Gomez, D Escobar, C Corey, B Ataya, J Luciano, AM Botero, L Gordon, J Brumfield, S Martinez, A Holder, O Ogundele, M Pinsky, S Shiva, BS Zuckerbraun |
Nitric Oxide | 2015 |
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Hydrogen peroxide-activatable antioxidant prodrug as a targeted therapeutic agent for ischemia-reperfusion injury
D Lee, S Park, S Bae, D Jeong, M Park, C Kang, W Yoo, MA Samad, Q Ke, G Khang, PM Kang |
Scientific Reports | 2015 |
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Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin–NO Biochemistry
GG Xu, TM Deshpande, MS Ghatge, AY Mehta, AS Omar, MH Ahmed, J Venitz, O Abdulmalik, Y Zhang, MK Safo |
Biochemistry | 2015 |
|
Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults
AE DeVan, LC Johnson, FA Brooks, TD Evans, JN Justice, C Cruickshank-Quinn, N Reisdorph, NS Bryan, MB McQueen, JR Santos-Parker, MB Chonchol, CJ Bassett, AL Sindler, T Giordano, DR Seals |
Journal of applied physiology | 2015 |
|
Randomized Phase 2 Trial of Intra-Coronary Nitrite During Acute Myocardial Infarction
DA Jones, C Pellaton, S Velmurugan, M Andiapen, S Antoniou, S Eijl, AJ Webb, M Westwood, M Parmar, A Mathur, A Ahluwalia |
Circulation research | 2014 |
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A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation
JD Lang, AB Smith, A Brandon, KM Bradley, Y Liu, W Li, DR Crowe, NC Jhala, RC Cross, L Frenette, K Martay, YL Vater, AA Vitin, GA Dembo, DA Dubay, JS Bynon, JM Szychowski, JD Reyes, JB Halldorson, SC Rayhill, AA Dick, R Bakthavatsalam, J Brandenberger, JA Broeckel-Elrod, L Sissons-Ross, T Jordan, LY Chen, A Siriussawakul, DE Eckhoff, RP Patel |
PloS one | 2014 |
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Is Nitrite the Circulating Endocrine Effector of Remote Ischemic Preconditioning?
P Corti, MT Gladwin |
Circulation research | 2014 |
|
Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy
JO Bouhidel, P Wang, KL Siu, H Li, JY Youn, H Cai |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 |
|
Inorganic nitrite supplementation for healthy arterial aging
AL Sindler, AE DeVan, BS Fleenor, DR Seals |
Journal of applied physiology | 2014 |
|
Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice
J Zhu, K Cui, J Kou, S Wang, Y Xu, Z Ding, R Han, Z Qin |
Evidence-Based Complementary and Alternative Medicine | 2014 |
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Abnormal Mitochondrial L-Arginine Transport Contributes to the Pathogenesis of Heart Failure and Rexoygenation Injury
D Williams, KM Venardos, M Byrne, M Joshi, D Horlock, NT Lam, P Gregorevic, SL McGee, DM Kaye, J Sadoshima |
PloS one | 2014 |
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Nitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide-Mediated Cytoprotective Signaling
S Bhushan, K Kondo, DJ Polhemus, H Otsuka, CK Nicholson, YX Tao, H Huang, VV Georgiopoulou, T Murohara, JW Calvert, J Butler, DJ Lefer |
Circulation research | 2014 |
|
Mechanisms of nitrite bioactivation
DB Kim-Shapiro, MT Gladwin |
Nitric Oxide | 2014 |
|
Endothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?
MM Cortese-Krott, M Kelm |
Redox Biology | 2014 |
|
Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
N Siddiqi, C Neil, M Bruce, G MacLennan, S Cotton, S Papadopoulou, M Feelisch, N Bunce, PO Lim, D Hildick-Smith, J Horowitz, M Madhani, N Boon, D Dawson, JC Kaski, M Frenneaux, N Siddiqi, C Neil, M Bruce, G MacLennan, S Cotton, D Dawson, M Frenneaux, S Singh, K Schwarz, B Jagpal, M Metcalfe, A Stewart, A Hannah, N Awsan, P Broadhurst, D Hogg, D Garg, E Slattery, T Davidson, A McDonald, G McPherson, JC Kaski, PO Lim, S Brown, SA Papadopoulou, F Gonzalvez, D Roy, S Firoozi, R Bogle, E Roberts, J Rhodes, D Hildick-Smith, A Belder, N Cooter, L Bennett, J Horowitz, S Rajendran, R Dautov, M Black, E Jansen, N Boon, A Struthers, W Toff, H Dargie, C Lang, P Nightingale |
European Heart Journal | 2014 |
|
Redox therapeutics in hepatic ischemia reperfusion injury
RP Patel, JD Lang, AB Smith, JH Crawford |
World journal of hepatology | 2014 |
|
Mitochondria selective S -nitrosation by mitochondria-targeted S -nitrosothiol protects against post-infarct heart failure in mouse hearts: MitoSNO protects from post-infarct heart failure
C Methner, ET Chouchani, G Buonincontri, VR Pell, SJ Sawiak, MP Murphy, T Krieg |
European Journal of Heart Failure | 2014 |
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Polymeric optical sensors for selective and sensitive nitrite detection using cobalt(iii) corrole and rh(iii) porphyrin as ionophores
S Yang, Y Wo, ME Meyerhoff |
Analytica Chimica Acta | 2014 |
|
Nitrite as Direct S-Nitrosylating Agent of Kir2.1 Channels
G Montesanti, ML Parisella, G Garofalo, D Pellegrino |
International Scholarly Research Notices | 2014 |
|
Crosstalk between Nitrite, Myoglobin and Reactive Oxygen Species to Regulate Vasodilation under Hypoxia
M Totzeck, UB Hendgen-Cotta, M Kelm, T Rassaf |
PloS one | 2014 |
|
Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion
B Björnsson, A Winbladh, L Bojmar, T Sundqvist, P Gullstrand, P Sandström |
World journal of gastroenterology : WJG | 2014 |
|
Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide
LY Guan, PY Fu, PD Li, ZN Li, HY Liu, MG Xin, W Li |
World journal of gastrointestinal surgery | 2014 |
|
The Preventive Effects of Diminazene Aceturate in Renal Ischemia/Reperfusion Injury in Male and Female Rats
M Malek, M Nematbakhsh |
Advances in Preventive Medicine | 2014 |
|
Dietary intake and bio-activation of nitrite and nitrate in newborn infants
JA Jones, AO Hopper, GG Power, AB Blood |
Pediatric Research | 2014 |
|
Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease
DJ Polhemus, DJ Lefer |
Circulation research | 2014 |
|
Nitrite therapy improves survival postexposure to chlorine gas
J Honavar, S Doran, JY Oh, C Steele, S Matalon, RP Patel |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
|
Nitrite in organ protection: Nitrite protects organs
T Rassaf, P Ferdinandy, R Schulz |
British Journal of Pharmacology | 2013 |
|
Nitrite Signaling in Pulmonary Hypertension: Mechanisms of Bioactivation, Signaling, and Therapeutics
M Bueno, J Wang, AL Mora, MT Gladwin |
Antioxidants & Redox Signaling | 2013 |
|
Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia–reperfusion
CK Nicholson, JP Lambert, CW Chow, DJ Lefer, JW Calvert |
Journal of Molecular and Cellular Cardiology | 2013 |
|
Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function
S Shiva |
Redox Biology | 2013 |
|
Malaria biology and disease pathogenesis: insights for new treatments
LH Miller, HC Ackerman, X Su, TE Wellems |
Nature Medicine | 2013 |
|
Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells
XJ Zhao, L Wang, S Shiva, J Tejero, MM Myerburg, J Wang, S Frizzell, MT Gladwin |
Free radical biology & medicine | 2013 |
|
Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy
AR Tonelli, S Haserodt, M Aytekin, RA Dweik |
Pulmonary circulation | 2013 |
|
Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion
CK Pride, L Mo, K Quesnelle, RK Dagda, D Murillo, L Geary, C Corey, R Portella, S Zharikov, CS Croix, S Maniar, CT Chu, NK Khoo, S Shiva |
Cardiovascular Research | 2013 |
|
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
J Yang, AT Gonon, PO Sjoquist, JO Lundberg, J Pernow |
Proceedings of the National Academy of Sciences | 2013 |
|
Intracellular ATP concentration contributes to the cytotoxic and cytoprotective effects of adenosine
S Li, X Li, H Guo, S Liu, H Huang, N Liu, C Yang, P Tang, J Liu |
PloS one | 2013 |
|
Regulation of gap junctions by nitric oxide influences the generation of arrhythmias resulting from acute ischemia and reperfusion in vivo
A Végh, M Gönczi, G Miskolczi, M Kovács |
Frontiers in pharmacology | 2013 |
|
The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial
DA Jones, M Andiapen, TJ Van-Eijl, AJ Webb, S Antoniou, RJ Schilling, A Ahluwalia, A Mathur |
BMJ Open | 2013 |
|
Nitric oxide and its metabolites in the critical phase of illness: rapid biomarkers in the making
AI Mian, M Aranke, NS Bryan |
The open biochemistry journal | 2013 |
|
Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway
S Lidder, AJ Webb |
British Journal of Clinical Pharmacology | 2013 |
|
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
ET Chouchani, C Methner, SM Nadtochiy, A Logan, VR Pell, S Ding, AM James, HM Cochemé, J Reinhold, KS Lilley, L Partridge, IM Fearnley, AJ Robinson, RC Hartley, RA Smith, T Krieg, PS Brookes, MP Murphy |
Nature Medicine | 2013 |
|
Role of β-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection
JW Calvert, DJ Lefer |
Physiology (Bethesda, Md.) | 2013 |
|
Cardioprotection and myocardial reperfusion: pitfalls to clinical application
RS Heide, C Steenbergen |
Circulation research | 2013 |
|
Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite
L Bellavia, JF DuMond, A Perlegas, SB King, DB Kim-Shapiro |
Nitric Oxide | 2013 |
|
Nitrite and Nitrate Concentrations and Metabolism in Breast Milk, Infant Formula, and Parenteral Nutrition
JA Jones, JR Ninnis, AO Hopper, Y Ibrahim, TA Merritt, KW Wan, GG Power, AB Blood |
JPEN. Journal of parenteral and enteral nutrition | 2013 |
|
Enrichment of live unlabelled cardiomyocytes from heterogeneous cell populations using manipulation of cell settling velocity by magnetic field
A Sofla, B Cirkovic, A Hsieh, JW Miklas, N Filipovic, M Radisic |
Biomicrofluidics | 2013 |
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Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis
KC Wood, MM Cortese-Krott, JC Kovacic, A Noguchi, VB Liu, X Wang, N Raghavachari, M Boehm, GJ Kato, M Kelm, MT Gladwin |
Arteriosclerosis, thrombosis, and vascular biology | 2013 |
|
Updated role of nitric oxide in disorders of erythrocyte function.
Kahn MJ, Maley JH, Lasker GF, Kadowitz PJ |
Cardiovascular & hematological disorders drug targets | 2013 |
|
Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase
L Mo, Y Wang, L Geary, C Corey, MJ Alef, D Beer-Stolz, BS Zuckerbraun, S Shiva |
Free radical biology & medicine | 2012 |
|
Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases
SC Bir, Y Xiong, CG Kevil, J Luo |
Cardiovascular Research | 2012 |
|
Nitrite and nitric oxide metabolism in peripheral artery disease
JD Allen, T Giordano, CG Kevil |
Nitric Oxide | 2012 |
|
Nitrite therapy is neuroprotective and safe in cardiac arrest survivors
C Dezfulian, A Alekseyenko, KR Dave, AP Raval, R Do, F Kim, MA Perez-Pinzon |
Nitric Oxide | 2012 |
|
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function
N Neye, F Enigk, S Shiva, H Habazettl, N Plesnila, H Kuppe, MT Gladwin, WM Kuebler |
Intensive Care Medicine | 2012 |
|
Comparing beneficial effects of inhaled nitric oxide to l-arginine in necrotizing enterocolitis model in neonatal rats
F Çekmez, T Purtuloğlu, G Aydemir, S Aydinoz, K Fidancı, A Karaoğlu, O Babacan, FE Canpolat, M Çetinkaya, T Tunc, S Süleymanoglu |
Pediatric Surgery International | 2012 |
|
The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury
W Li, Z Meng, Y Liu, RP Patel, JD Lang |
Journal of Transplantation | 2012 |
|
Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function
SS Kelpke, B Chen, KM Bradley, X Teng, P Chumley, A Brandon, B Yancey, B Moore, H Head, L Viera, JA Thompson, DK Crossman, MS Bray, DE Eckhoff, A Agarwal, RP Patel |
Kidney International | 2012 |
|
Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?
A Siriussawakul, LI Chen, JD Lang |
Journal of Transplantation | 2012 |
|
Single-Dose Pharmacokinetics of Different Oral Sodium Nitrite Formulations in Diabetes Patients
FL Greenway, BL Predmore, DR Flanagan, T Giordano, Y Qiu, A Brandon, DJ Lefer, RP Patel, CG Kevil |
Diabetes Technology & Therapeutics | 2012 |
|
Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production
AT Gonon, C Jung, A Katz, H Westerblad, A Shemyakin, PO Sjöquist, JO Lundberg, J Pernow |
PloS one | 2012 |
|
Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: Mechanisms and implications
L Xi, SG Zhu, A Das, Q Chen, D Durrant, DC Hobbs, EJ Lesnefsky, RC Kukreja |
Nitric Oxide | 2012 |
|
A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress
Q Chen, ME Fabry, AC Rybicki, SM Suzuka, TC Balazs, Z Etzion, K Jong, EK Akoto, JE Canterino, DK Kaul, FA Kuypers, D Lefer, EE Bouhassira, RE Hirsch |
Blood cells, molecules & diseases | 2012 |
|
Physiological role for nitrate-reducing oral bacteria in blood pressure control
V Kapil, SM Haydar, V Pearl, JO Lundberg, E Weitzberg, A Ahluwalia |
Free radical biology & medicine | 2012 |
|
Mitochondria as a drug target in ischemic heart disease and cardiomyopathy
AM Walters, GA Porter, PS Brookes |
Circulation research | 2012 |
|
Oxygen Regulates Tissue Nitrite Metabolism
E Curtis, LL Hsu, AC Noguchi, L Geary, S Shiva |
Antioxidants & Redox Signaling | 2012 |
|
Myoglobin and mitochondria: A relationship bound by oxygen and nitric oxide
C Kamga, S Krishnamurthy, S Shiva |
Nitric Oxide | 2012 |
|
Nitrate reductase activity of bacteria in saliva of term and preterm infants
JA Kanady, AW Aruni, JR Ninnis, AO Hopper, JD Blood, BL Byrd, LR Holley, MR Staker, S Hutson, HM Fletcher, GG Power, AB Blood |
Nitric Oxide | 2012 |
|
Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modality
AA Samal, J Honavar, A Brandon, KM Bradley, S Doran, Y Liu, C Dunaway, C Steele, EM Postlethwait, GL Squadrito, MV Fanucchi, S Matalon, RP Patel |
Free radical biology & medicine | 2012 |
|
Hydrogen Sulfide Stimulates Ischemic Vascular Remodeling Through Nitric Oxide Synthase and Nitrite Reduction Activity Regulating Hypoxia‐Inducible Factor‐1α and Vascular Endothelial Growth Factor–Dependent Angiogenesis
SC Bir, GK Kolluru, P McCarthy, X Shen, S Pardue, CB Pattillo, CG Kevil |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2012 |
|
Selective β 2 -Adrenoreceptor Stimulation Attenuates Myocardial Cell Death and Preserves Cardiac Function After Ischemia–Reperfusion Injury
S Bhushan, K Kondo, BL Predmore, M Zlatopolsky, AL King, C Pearce, H Huang, YX Tao, ME Condit, DJ Lefer |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
|
A Cell-Based Phenotypic Assay to Identify Cardioprotective Agents
S Guo, A Olm-Shipman, A Walters, WR Urciuoli, S Devito, SM Nadtochiy, AP Wojtovich, PS Brookes |
Circulation research | 2012 |
|
Dietary Nitrate Ameliorates Pulmonary Hypertension: Cytoprotective Role for Endothelial Nitric Oxide Synthase and Xanthine Oxidoreductase
RS Baliga, AB Milsom, SM Ghosh, SL Trinder, RJ MacAllister, A Ahluwalia, AJ Hobbs |
Circulation | 2012 |
|
Beets, Bacteria, and Blood Flow: A Lesson of Three Bs
GK Kolluru, CG Kevil |
Circulation | 2012 |
|
Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation
M Totzeck, UB Hendgen-Cotta, P Luedike, M Berenbrink, JP Klare, HJ Steinhoff, D Semmler, S Shiva, D Williams, A Kipar, MT Gladwin, J Schrader, M Kelm, AR Cossins, T Rassaf |
Circulation | 2012 |
|
Nitrite-Generated Nitric Oxide Circumvents Dysregulated Arginine/Nitric Oxide Synthase Signaling To Protect Against Intimal Hyperplasia In Sprague-Dawley Rats
Matthew Alef, Raghuveer Vallabhaneni, Evie Carchman, Sidney Morris, Sruti Shiva, Yinna Wang, Eric Kelley, Margaret Tarpey, Mark Gladwin, Edith Tzeng, Brian Zuckerbraun |
Journal of Clinical Investigation | 2011 |
|
Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers
RM Pluta, EH Oldfield, KD Bakhtian, AR Fathi, RK Smith, HL Devroom, M Nahavandi, S Woo, WD Figg, RR Lonser |
PloS one | 2011 |
|
Inhaled Nitric Oxide Therapy Increases Blood Nitrite, Nitrate, and S-Nitrosohemoglobin Concentrations in Infants with Pulmonary Hypertension
YI Ibrahim, JR Ninnis, AO Hopper, DD Deming, AX Zhang, JL Herring, LC Sowers, TJ McMahon, GG Power, AB Blood |
The Journal of Pediatrics | 2011 |
|
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits
A Machha, AN Schechter |
European Journal of Nutrition | 2011 |
|
Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly
AC Torregrossa, M Aranke, NS Bryan |
Journal of Geriatric Cardiology | 2011 |
|
Inorganic nitrite therapy: historical perspective and future directions
CG Kevil, GK Kolluru, CB Pattillo, T Giordano |
Free radical biology & medicine | 2011 |
|
Dietary Nitrate Supplementation Protects Against Doxorubicin-Induced Cardiomyopathy by Improving Mitochondrial Function
SG Zhu, RC Kukreja, A Das, Q Chen, EJ Lesnefsky, L Xi |
Journal of the American College of Cardiology | 2011 |
|
How to protect liver graft with nitric oxide
HB Abdennebi, MA Zaoualí, I Alfany-Fernandez, D Tabka, J Roselló-Catafau |
World journal of gastroenterology : WJG | 2011 |
|
Molecular mechanisms in exercise-induced cardioprotection
S Golbidi, I Laher |
Cardiology Research and Practice | 2011 |
|
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity
L Xi, SG Zhu, DC Hobbs, RC Kukreja |
Journal of Cellular and Molecular Medicine | 2011 |
|
Beta3-Adrenoreceptor Stimulation Ameliorates Myocardial Ischemia-Reperfusion Injury Via Endothelial Nitric Oxide Synthase and Neuronal Nitric Oxide Synthase Activation
JP Aragón, ME Condit, S Bhushan, BL Predmore, SS Patel, DB Grinsfelder, S Gundewar, S Jha, JW Calvert, LA Barouch, M Lavu, HM Wright, DJ Lefer |
Journal of the American College of Cardiology | 2011 |
|
Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral nephrectomy
C Foglieni, A Fulgenzi, D Belloni, C Sciorati, E Ferrero, ME Ferrero |
BMC Nephrology | 2011 |
|
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy
DA Vitturi, RP Patel |
Free radical biology & medicine | 2011 |
|
Saying Yes to Exercise and NO to Cardiac Injury
V Bezzerides, A Rosenzweig |
Circulation research | 2011 |
|
Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids and polyphenols
SM Nadtochiy, EK Redman |
Nutrition (Burbank, Los Angeles County, Calif.) | 2011 |
|
Nitrite as a mediator of ischemic preconditioning and cytoprotection
D Murillo, C Kamga, L Mo, S Shiva |
Nitric Oxide | 2011 |
|
Soluble guanylate cyclase-α1 is required for the cardioprotective effects of inhaled nitric oxide
Y Nagasaka, ES Buys, E Spagnolli, AU Steinbicker, SR Hayton, KM Rauwerdink, P Brouckaert, WM Zapol, KD Bloch |
American journal of physiology. Heart and circulatory physiology | 2011 |
|
Dietary nitrate - a slow train coming
E Weitzberg, JO Lundberg |
The Journal of Physiology | 2011 |
|
Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: A randomized clinical trial
Gladwin MT, Kato GJ, Weiner D, Onyekwere OC, Dampier C, Hsu L, Hagar RW, Howard T, Nuss R, Okam MM, Tremonti CK, Berman B, Villella A, Krishnamurti L, Lanzkron S, Castro O, Gordeuk VR, Coles WA, Peters-Lawrence M, Nichols J, Hall MK, Hildesheim M, Blackwelder WC, Baldassarre J, Casella JF |
Journal of the American Medical Association | 2011 |
|
Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases
Stefano GB, Kream RM |
Medical science monitor : international medical journal of experimental and clinical research | 2011 |
|
Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases
CB Pattillo, S Bir, V Rajaram, CG Kevil |
Cardiovascular Research | 2010 |
|
Role of nitric oxide in hepatic ischemia-reperfusion injury
A Siriussawakul, A Zaky, JD Lang |
World journal of gastroenterology : WJG | 2010 |
|
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
RP Patel, N Hogg, DB Kim-Shapiro |
Cardiovascular Research | 2010 |
|
Nitrates and Nitrites in the Treatment of Ischemic Cardiac Disease
VE Nossaman, BD Nossaman, PJ Kadowitz |
Cardiology in Review | 2010 |
|
Effect of L-arginine Oral Supplementation on Response to Myocardial Infarction in Hypercholesterolemic and Hypertensive Rats
V Piñeiro, A Ortiz-Moreno, R Mora-Escobedo, MD Hernández-Navarro, G Ceballos-Reyes, G Chamorro-Cevallos |
Plant Foods for Human Nutrition | 2010 |
|
Cardioprotective effects of nitrite during exercise
JW Calvert |
Cardiovascular Research | 2010 |
|
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
BS Zuckerbraun, P George, MT Gladwin |
Cardiovascular Research | 2010 |
|
Mitochondria as metabolizers and targets of nitrite
S Shiva |
Nitric Oxide | 2010 |
|
Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism
J Zhang, H Cai |
Journal of Molecular and Cellular Cardiology | 2010 |
|
A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
GF Lasker, JH Maley, PJ Kadowitz |
Advances in pharmacological sciences | 2010 |
|
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation
JO Ormerod, H Ashrafian, AR Maher, S Arif, V Steeples, GV Born, S Egginton, M Feelisch, H Watkins, MP Frenneaux |
Cardiovascular Research | 2010 |
|
Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
A Siciliano, G Malpeli, OS Platt, C Lebouef, A Janin, A Scarpa, O Olivieri, E Amato, R Corrocher, Y Beuzard, LD Franceschi |
Haematologica | 2010 |
|
The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition
S Shiva, T Rassaf, RP Patel, MT Gladwin |
Cardiovascular Research | 2010 |
|
Clinical Translation of Nitrite Therapy for Cardiovascular Diseases
JW Calvert, DJ Lefer |
Nitric Oxide | 2010 |
|
Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
AK Yadav, SF Doran, AA Samal, R Sharma, K Vedagiri, EM Postlethwait, GL Squadrito, MV Fanucchi, LJ 2nd, RP Patel, S Matalon |
AJP Lung Cellular and Molecular Physiology | 2010 |
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Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat
AM Badejo, C Hodnette, JS Dhaliwal, DB Casey, E Pankey, SN Murthy, BD Nossaman, AL Hyman, PJ Kadowitz |
American journal of physiology. Heart and circulatory physiology | 2010 |
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Nitrite reduction by xanthine oxidase family enzymes: a new class of nitrite reductases
LB Maia, JJ Moura |
JBIC Journal of Biological Inorganic Chemistry | 2010 |
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Genome expression profiling and network analysis of nitrite therapy during chronic ischemia: Possible mechanisms and interesting molecules
CB Pattillo, K Fang, S Pardue, CG Kevil |
Nitric Oxide | 2010 |
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Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
YY Hon, H Sun, A Dejam, MT Gladwin |
Drug Metabolism and Disposition | 2010 |
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Protein S -Nitrosylation and Cardioprotection
J Sun, E Murphy |
Circulation research | 2010 |
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Bioinspired Heme, Heme/Nonheme Diiron, Heme/Copper, and Inorganic NOx Chemistry: •NO (g) Oxidation, Peroxynitrite−Metal Chemistry, and •NO (g) Reductive Coupling
MP Schopfer, J Wang, KD Karlin |
Inorganic Chemistry | 2010 |
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A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration, and clinical implications
Songqing He, Carl Atkinson, Fei Qiao, Katherine Cianflone , Xiaoping Chen and Stephen Tomlinson |
Journal of Clinical Investigation | 2009 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Heart Failure Management: The Present and the Future
MN Jameel, J Zhang |
Antioxidants & Redox Signaling | 2009 |
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Nitrite as regulator of hypoxic signaling in mammalian physiology
EE van Faassen, S Bahrami, M Feelisch, N Hogg, M Kelm, DB Kim-Shapiro, AV Kozlov, H Li, JO Lundberg, R Mason, H Nohl, T Rassaf, A Samouilov, A Slama-Schwok, S Shiva, AF Vanin, E Weitzberg, J Zweier, MT Gladwin |
Medicinal Research Reviews | 2009 |
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Myocardial protection by nitrite
JW Calvert, DJ Lefer |
Cardiovascular Research | 2009 |
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Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner
A Cauwels, ES Buys, R Thoonen, L Geary, J Delanghe, S Shiva, P Brouckaert |
Journal of Experimental Medicine | 2009 |
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Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms
CC Lim, NS Bryan, M Jain, MF Garcia-Saura, BO Fernandez, DB Sawyer, DE Handy, J Loscalzo, M Feelisch, R Liao |
American journal of physiology. Heart and circulatory physiology | 2009 |
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Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response
NJ Raat, AC Noguchi, VB Liu, N Raghavachari, D Liu, X Xu, S Shiva, PJ Munson, MT Gladwin |
Free radical biology & medicine | 2009 |
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The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies
B Piknova, A Keszler, N Hogg, AN Schechter |
Nitric Oxide | 2009 |
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Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: Potential role in cardioprotection
NL Lohr, A Keszler, P Pratt, M Bienengraber, DC Warltier, N Hogg |
Journal of Molecular and Cellular Cardiology | 2009 |
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Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation
Z Cao, JB Bell, JG Mohanty, E Nagababu, JM Rifkind |
American journal of physiology. Heart and circulatory physiology | 2009 |
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Plasma nitrite response and arterial reactivity differentiate vascular health and performance
JD Allen, EM Miller, E Schwark, JL Robbins, BD Duscha, BH Annex |
Nitric Oxide | 2009 |
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Mechanistic Insights Into Nitrite-Induced Cardioprotection Using an Integrated Metabolomic/Proteomic Approach
DH Perlman, SM Bauer, H Ashrafian, NS Bryan, MF Garcia-Saura, CC Lim, BO Fernandez, G Infusini, ME McComb, CE Costello, M Feelisch |
Circulation research | 2009 |
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Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I
C Dezfulian, S Shiva, A Alekseyenko, A Pendyal, DG Beiser, JP Munasinghe, SA Anderson, CF Chesley, TL Hoek, MT Gladwin |
Circulation | 2009 |
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Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
FM Gonzalez, S Shiva, PS Vincent, LA Ringwood, LY Hsu, YY Hon, AH Aletras, RO 3rd, MT Gladwin, AE Arai |
Circulation | 2008 |
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Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
AJ Webb, N Patel, S Loukogeorgakis, M Okorie, Z Aboud, S Misra, R Rashid, P Miall, J Deanfield, N Benjamin, R MacAllister, AJ Hobbs, A Ahluwalia |
Hypertension | 2008 |
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Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury
UB Hendgen-Cotta, MW Merx, S Shiva, J Schmitz, S Becher, JP Klare, HJ Steinhoff, A Goedecke, J Schrader, MT Gladwin, M Kelm, T Rassaf |
Proceedings of the National Academy of Sciences | 2008 |
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Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis
D Kumar, BG Branch, CB Pattillo, J Hood, S Thoma, S Simpson, S Illum, N Arora, JH Chidlow, W Langston, X Teng, DJ Lefer, RP Patel, CG Kevil |
Proceedings of the National Academy of Sciences | 2008 |
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Targeting the mitochondria to augment myocardial protection
DR Schwartz, MN Sack |
Current Opinion in Pharmacology | 2008 |
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The functional nitrite reductase activity of the heme-globins
MT Gladwin, DB Kim-Shapiro |
Blood | 2008 |
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Effect of inhaled nitric oxide on cerebrospinal fluid and blood nitrite concentrations in newborn lambs
GR Conahey, GG Power, AO Hopper, MH Terry, LS Kirby, AB Blood |
Pediatric Research | 2008 |
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Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
JW Elrod, JW Calvert, S Gundewar, NS Bryan, DJ Lefer |
Proceedings of the National Academy of Sciences | 2008 |
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Inhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension
B Yu, MJ Raher, GP Volpato, KD Bloch, F Ichinose, WM Zapol |
Circulation | 2008 |
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Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
SK Mantena, AL King, KK Andringa, HB Eccleston, SM Bailey |
Free radical biology & medicine | 2008 |
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Mechanisms Underlying Acute Protection from Cardiac Ischemia-Reperfusion Injury
E Murphy, C Steenbergen |
Physiological reviews | 2008 |
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Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis
PC Minneci, KJ Deans, S Shiva, H Zhi, SM Banks, S Kern, C Natanson, SB Solomon, MT Gladwin |
American journal of physiology. Heart and circulatory physiology | 2008 |
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Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study
AK Mack, VR McGowan, CK Tremonti, D Ackah, C Barnett, RF Machado, MT Gladwin, GJ Kato |
British Journal of Haematology | 2008 |
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Brief Periods of Nitric Oxide Inhalation Protect against Myocardial Ischemia–Reperfusion Injury
Y Nagasaka, BO Fernandez, MF Garcia-Saura, B Petersen, F Ichinose, KD Bloch, M Feelisch, WM Zapol |
Anesthesiology | 2008 |
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Renal hemodynamic and excretory responses to intra-arterial infusion of peroxynitrite in anesthetized rats
LC Matavelli, PJ Kadowitz, LG Navar, DS Majid |
American journal of physiology. Renal physiology | 2008 |
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Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy
GJ Kato, MT Gladwin |
JAMA : the journal of the American Medical Association | 2008 |
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Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
NS Bryan, JW Calvert, S Gundewar, DJ Lefer |
Free radical biology & medicine | 2008 |
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Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat
DB Casey, AM Badejo, JS Dhaliwal, SN Murthy, AL Hyman, BD Nossaman, PJ Kadowitz |
American journal of physiology. Heart and circulatory physiology | 2008 |
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Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection
SM Nadtochiy, PR Baker, BA Freeman, PS Brookes |
Cardiovascular Research | 2008 |
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Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy
CG Kevil, RP Patel |
Expert Review of Cardiovascular Therapy | 2008 |
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Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors
PH McNulty, S Scott, V Kehoe, M Kozak, LI Sinoway, J Li |
American journal of physiology. Heart and circulatory physiology | 2008 |
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Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations
ZN Zahran, L Chooback, DM Copeland, AH West, GB Richter-Addo |
Journal of Inorganic Biochemistry | 2008 |
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Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway
H Strijdom, SO Friedrich, S Hattingh, N Chamane, A Lochner |
Molecular and Cellular Biochemistry | 2008 |
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Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase
AJ Webb, AB Milsom, KS Rathod, WL Chu, S Qureshi, MJ Lovell, FM Lecomte, D Perrett, C Raimondo, E Khoshbin, Z Ahmed, R Uppal, N Benjamin, AJ Hobbs, A Ahluwalia |
Circulation research | 2008 |
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Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation
YY Chen, HM Chu, KT Pan, CH Teng, DL Wang, AH Wang, KH Khoo, TC Meng |
The Journal of biological chemistry | 2008 |
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Preemptive Administration of Inhaled Nitric Oxide Accelerates Restoration of Liver Function in Adults Following Orthotopic Liver Transplantation
John D Lang Jr Xinjun Teng Phillip Chumley Jack H Crawford T. Scott Isbell Balu K Chacko Yuliang Liu Nirag Jhala D. Ralph Crowe Alvin B Smith Richard C Cross Luc Frenette Eric E Kelley Diana W Wilhite Cheryl R Hall Grier P Page Michael B Fallon J Steven Bynon Devin E Eckhoff Rakesh P. Patel |
Journal of Clinical Investigation | 2007 |
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Nitric oxide and peroxynitrite in health and disease
P Pacher, JS Beckman, L Liaudet |
Physiological reviews | 2007 |
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Inhaled NO as a therapeutic agent
KD Bloch, F Ichinose, JD Roberts, WM Zapol |
Cardiovascular Research | 2007 |
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Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
C Dezfulian, N Raat, S Shiva, MT Gladwin |
Cardiovascular Research | 2007 |
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Nitric oxide synthase-derived plasma nitrite predicts exercise capacity
T Rassaf, T Lauer, C Heiss, J Balzer, S Mangold, T Leyendecker, J Rottler, C Drexhage, C Meyer, M Kelm |
British journal of sports medicine | 2007 |
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Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review
PK Chatterjee |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2007 |
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Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
S Shiva, MN Sack, JJ Greer, M Duranski, LA Ringwood, L Burwell, X Wang, PH MacArthur, A Shoja, N Raghavachari, JW Calvert, PS Brookes, DJ Lefer, MT Gladwin |
Journal of Experimental Medicine | 2007 |
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Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
NS Bryan, JW Calvert, JW Elrod, S Gundewar, SY Ji, DJ Lefer |
Proceedings of the National Academy of Sciences | 2007 |
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Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and KATP channels
JE Baker, J Su, X Fu, A Hsu, GJ Gross, JS Tweddell, N Hogg |
Journal of Molecular and Cellular Cardiology | 2007 |
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Cardioprotection and mitochondrial S-nitrosation: Effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia–reperfusion injury
SM Nadtochiy, LS Burwell, PS Brookes |
Journal of Molecular and Cellular Cardiology | 2007 |
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Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets.
Albert J, Harbut P, Zieliński S, Ryniak S, Gillis-Haegerstrand C, Lindwall R, Solski L, Lundberg JO, Svensson J, Goździk W |
Intensive Care Medicine | 2007 |
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S-nitrosylation: NO-related redox signaling to protect against oxidative stress
J Sun, C Steenbergen, E Murphy |
Antioxidants & Redox Signaling | 2006 |
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Direct evidence for S-nitrosation of mitochondrial complex I
LS Burwell, SM Nadtochiy, AJ Tompkins, S Young, PS Brookes |
Biochemical Journal | 2006 |
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Allylic Nitro Compounds as Nitrite Donors
H Chakrapani, MJ Gorczynski, SB King |
Journal of the American Chemical Society | 2006 |
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Enzymatic Function of Hemoglobin as a Nitrite Reductase that Produces Nitric Oxide under Allosteric Control
Zhi Huang, Sruti Shiva, Daniel B. Kim-Shapiro, Rakesh P. Patel, Lorna A. Ringwood, Cynthia E. Irby, Kris T. Huang, Chien Ho, Alan N. Schechter, Neil Hogg, Mark T. Gladwin |
Journal of Clinical Investigation | 2005 |
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