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Janakiraman Krishnamurthy, … , Lishan Su, Norman E. Sharpless
Published November 1, 2004
Citation Information: J Clin Invest. 2004;114(9):1299-1307. https://doi.org/10.1172/JCI22475.
Citation Information: J Clin Invest. 2004;114(9):1299-1307. https://doi.org/10.1172/JCI22475.
Abstract
The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are principal mediators of cellular senescence. To study the links between senescence and aging in vivo, we examined Ink4a/Arf expression in rodent models of aging. We show that expression of p16INK4a and Arf markedly increases in almost all rodent tissues with advancing age, while there is little or no change in the expression of other related cell cycle inhibitors. The increase in expression is restricted to well-defined compartments within each organ studied and occurs in both epithelial and stromal cells of diverse lineages. The age-associated increase in expression of p16INK4a and Arf is attenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with diminished expression of an in vivo marker of senescence, as well as decreased pathology of those organs. Last, the age-related increase in Ink4a/Arf expression can be independently attributed to the expression of Ets-1, a known p16INK4a transcriptional activator, as well as unknown Ink4a/Arf coregulatory molecules. These data suggest that expression of the Ink4a/Arf tumor suppressor locus is a robust biomarker, and possible effector, of mammalian aging.
Authors
Janakiraman Krishnamurthy, Chad Torrice, Matthew R. Ramsey, Grigoriy I. Kovalev, Khalid Al-Regaiey, Lishan Su, Norman E. Sharpless
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Citations to this article (804)
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Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium
Zhang X, Tyrrell DJ, Alliston T, Schilling B, Yousefzadeh MJ, Schafer MJ |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2023 |
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Cell senescence, the senescence-associated secretory phenotype, and cancers
Langhi Prata LG, Tchkonia T, Kirkland JL |
PLoS Biology | 2023 |
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Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo
Samra T, Gomez-Gomez T, Linowiecka K, Akhundlu A, Lopez de Mendoza G, Gompels M, Lee WW, Gherardini J, Chéret J, Paus R |
International journal of molecular sciences | 2023 |
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The Nutriepigenome
Mirisola MG |
Genes & development | 2023 |
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Accumulation of senescent cells in the stroma of aged mouse ovary
MARUYAMA N, FUKUNAGA I, KOGO T, ENDO T, FUJII W, KANAI-AZUMA M, NAITO K, SUGIURA K |
Journal of Reproduction and Development | 2023 |
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Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Kumar A, Thirumurugan K |
Cell cycle (Georgetown, Tex.) | 2023 |
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Impaired Efferocytosis Enables Apoptotic Osteoblasts to Escape Osteoimmune Surveillance During Aging.
Xu R, Xie H, Shen X, Huang J, Zhang H, Fu Y, Zhang P, Guo S, Wang D, Li S, Zheng K, Sun W, Liu L, Cheng J, Jiang H |
2023 | |
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Molecular and Functional Key Features and Oncogenic Drivers in Thymic Carcinomas.
Barachini S, Pardini E, Burzi IS, Sardo Infirri G, Montali M, Petrini I |
Cancers | 2023 |
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Calorie restriction reduces biomarkers of cellular senescence in humans.
Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJA, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK |
Aging Cell | 2023 |
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Cellular Senescence and the Skeleton: Pathophysiology and Therapeutic Implications
Sundeep Khosla, Joshua Farr, David Monroe |
Journal of Clinical Investigation | 2022 |
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The Achilles heel of cancer survivors: fundamentals of accelerated cellular senescence
Shameel Shafqat, Evelyn Arana Chicas, Areez Shafqat, Shahrukh Hashmi |
Journal of Clinical Investigation | 2022 |
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Cellular Senescence: A Key Therapeutic Target in Aging and Diseases
Lei Zhang, Louise Pitcher, Matthew Yousefzadeh, Laura Niedernhofer, Paul Robbins, Yi Zhu |
Journal of Clinical Investigation | 2022 |
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A critical evaluation of risk to reward ratio of quercetin supplementation for COVID ‐19 and associated comorbid conditions
A Pawar, M Russo, I Rani, K Goswami, G Russo, A Pal |
Phytotherapy research : PTR | 2022 |
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Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory
Y Takei, Y Amagase, K Iida, T Sagawa, A Goto, R Kambayashi, H Izumi-Nakaseko, A Matsumoto, S Kawai, A Sugiyama, T Takada, A Hirasawa |
GeroScience | 2022 |
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Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection
O Elsallabi, A Patruno, M Pesce, A Cataldi, S Carradori, M Gallorini |
Molecules (Basel, Switzerland) | 2022 |
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Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities
R Sharma |
Probiotics and Antimicrobial Proteins | 2022 |
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miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells
W da Silveira, L Renaud, E Hazard, G Hardiman |
Genes & development | 2022 |
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Lipids as Regulators of Cellular Senescence
S Hamsanathan, A Gurkar |
Frontiers in physiology | 2022 |
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Cellular Senescence in Aging Lungs and Diseases
Aghali A, Koloko Ngassie ML, Pabelick CM, Prakash YS |
Cells | 2022 |
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Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging
Zorina A, Zorin V, Kudlay D, Kopnin P |
International journal of molecular sciences | 2022 |
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Characterization of transcriptional landscape in bone marrow-derived mesenchymal stromal cells treated with aspirin by RNA-seq.
Liu X, Zhan Y, Xu W, Liu L, Liu X, Da J, Zhang K, Zhang X, Wang J, Liu Z, Jin H, Zhang B, Li Y |
PeerJ | 2022 |
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Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes
Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PE, Deng T, Chen N, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E |
The EMBO Journal | 2022 |
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Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging
Safwan-Zaiter H, Wagner N, Michiels JF, Wagner KD |
Cells | 2022 |
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The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
Wagner KD, Wagner N |
Cells | 2022 |
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Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16.
Zhao H, Zhao T, Yang J, Huang Q, Wu H, Pan Y, Wang H, Qian Y |
Cell Death and Disease | 2022 |
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Prognostic Significance of p16 Protein Expression in Breast Cancer.
Salih MM, Higgo AA, Eed EM |
In vivo (Athens, Greece) | 2022 |
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Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.
Kang D, Lee J, Jung J, Carlson BA, Chang MJ, Chang CB, Kang SB, Lee BC, Gladyshev VN, Hatfield DL, Lee BJ, Kim JH |
Nature Communications | 2022 |
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Systems approaches to investigate the role of NF-κB signaling in aging
Haga M, Okada M |
Biochemical Journal | 2022 |
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Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects
Rhinn M, Zapata-Bodalo I, Klein A, Plassat JL, Knauer-Meyer T, Keyes WM |
PLoS Biology | 2022 |
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Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review
Diwan B, Sharma R |
Food Science and Biotechnology | 2022 |
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Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3
Takaya K, Asou T, Kishi K |
International journal of molecular sciences | 2022 |
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Revisiting Epithelial Carcinogenesis.
Méndez-López LF |
International journal of molecular sciences | 2022 |
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Mechanisms involved in hematopoietic stem cell aging.
Fujino T, Asada S, Goyama S, Kitamura T |
Cellular and molecular life sciences : CMLS | 2022 |
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Nanoparticles-based anti-aging treatment of Alzheimer's disease.
Chu JJ, Ji WB, Zhuang JH, Gong BF, Chen XH, Cheng WB, Liang WD, Li GR, Gao J, Yin Y |
Drug Delivery | 2022 |
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Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis
Gil TH, Zheng H, Lee HG, Shin JW, Hwang SW, Jang KM, Jeon OH |
Aging | 2022 |
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Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
Farooq U, Notani D |
Frontiers in Cell and Developmental Biology | 2022 |
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P16INK4A—More Than a Senescence Marker
Safwan-Zaiter H, Wagner N, Wagner KD |
Life Sciences | 2022 |
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Comprehensive analysis of cellular senescence-related genes in the prognosis, tumor microenvironment, and immunotherapy/chemotherapy of clear cell renal cell carcinoma
Lu C, Wang Y, Nie L, Chen L, Li M, Qing H, Li S, Wu S, Wang Z |
Frontiers in immunology | 2022 |
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Cellular Senescence and Periodontitis: Mechanisms and Therapeutics.
Chen S, Zhou D, Liu O, Chen H, Wang Y, Zhou Y |
Biology | 2022 |
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Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.
Takaya K, Asou T, Kishi K |
Aging | 2022 |
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A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice.
Sun J, Wang M, Zhong Y, Ma X, Sun S, Xu C, Peng L, Li G, Zhang L, Liu Z, Ai D, Liu B |
Nature Communications | 2022 |
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Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan.
Kaur P, Otgonbaatar A, Ramamoorthy A, Chua EHZ, Harmston N, Gruber J, Tolwinski NS |
Aging | 2022 |
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Crosstalk between age accumulated DNA-damage and the SIRT1-AKT-GSK3ß axis in urine derived renal progenitor cells.
Erichsen L, Adjaye J |
Aging | 2022 |
|
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
Aghali A, Khalfaoui L, Lagnado AB, Drake LY, Teske JJ, Pabelick CM, Passos JF, Prakash YS |
AJP Lung Cellular and Molecular Physiology | 2022 |
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Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration.
Terao R, Ahmed T, Suzumura A, Terasaki H |
2022 | |
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β-(4-fluorobenzyl) Arteannuin B induced interaction of ATF-4 and C/EBPβ mediates the transition of breast cancer cells from autophagy to senescence.
Mir KB, Faheem MM, Ahmad SM, Rasool JU, Amin T, Chakraborty S, Bhagat M, Ahmed Z, Ali A, Goswami A |
Frontiers in Oncology | 2022 |
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Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats
Andrianova NV, Zorova LD, Pevzner IB, Kolosova NG, Plotnikov EY, Zorov DB |
International journal of molecular sciences | 2022 |
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Aging Fibroblasts Adversely Affect Extracellular Matrix Formation via the Senescent Humoral Factor Ependymin-Related Protein 1
Takaya K, Asou T, Kishi K |
Cells | 2022 |
|
Structural and Functional Changes in Aging Kidneys
Dybiec J, Szlagor M, Młynarska E, Rysz J, Franczyk B |
International journal of molecular sciences | 2022 |
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Does walking during chemotherapy impact p16(INK4a) levels in women with early breast cancer.
Kammire MS, Deal AM, Damone EM, Rosen V, Nyrop KA, Mitin N, Muss HB |
Journal of Clinical Laboratory Analysis | 2022 |
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Current Understanding of the Role of Senescent Melanocytes in Skin Ageing.
Hughes BK, Bishop CL |
Biomedicines | 2022 |
|
Comparative characterization of frozen-thawed CD146+ and CD146- subsets of CD73+CD90+CD105+CD34+ human ASCs
Yu Y, Li H |
Journal of stem cells & regenerative medicine | 2022 |
|
Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity
Su Z, Su H, Xu J, Wei G, Qu L, Ni T, Yang D, Zhu Y |
Aging | 2022 |
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Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet
Xu K, Guo Y, Wang Y, Ren Y, Low V, Cho S, Ping L, Peng K, Li X, Qiu Y, Liu Q, Li Z, Wang Z |
Aging Cell | 2022 |
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Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro.
Brauer E, Lange T, Keller D, Görlitz S, Cho S, Keye J, Gossen M, Petersen A, Kornak U |
Aging Cell | 2022 |
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Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury.
Boe DM, Hulsebus HJ, Najarro KM, Mullen JE, Kim H, Tan AC, McMahan RH, Kovacs EJ |
Journal of leukocyte biology | 2022 |
|
Social Justice and Equity: Why Older Adults with Cancer Belong - A Life Course Perspective
Yilmaz S, Sanapala C, Schiaffino MK, Schumacher JR, Wallington SF, McKoy JM, Canin B, Tang W, Tucker-Seeley RD, Simmons J, Gilmore N |
2022 | |
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IGF-1 Receptor Signaling Regulates Type II Pneumocyte Senescence and Resulting Macrophage Polarization in Lung Fibrosis
EJ Chung, S Kwon, JL Reedy, AO White, JS Song, I Hwang, JY Chung, K Ylaya, SM Hewitt, DE Citrin |
International journal of radiation oncology, biology, physics | 2021 |
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Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production
K Kawaguchi, K Komoda, R Mikawa, A Asai, M Sugimoto |
iScience | 2021 |
|
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1
C Cohen, OL Goff, F Soysouvanh, F Vasseur, M Tanou, C Nguyen, L Amrouche, JL Guen, O SaltelFulero, T Meunier, T NguyenKhoa, M Rabant, D Nochy, C Legendre, G Friedlander, BG Childs, DJ Baker, B Knebelmann, D Anglicheau, F Milliat, F Terzi |
EMBO Molecular Medicine | 2021 |
|
Reviews on New Drug Targets in Age-Related Disorders: Part II
PC Guest |
2021 | |
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Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
D Nie, J Zhang, Y Zhou, J Sun, W Wang, JH Wang, M Maioli |
Stem Cells International | 2021 |
|
Epigenetic Regulation of Genomic Stability by Vitamin C
JP Brabson, T Leesang, S Mohammad, L Cimmino |
Frontiers in Genetics | 2021 |
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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy, H Wang, Z Ju |
Signal Transduction and Targeted Therapy | 2021 |
|
Bone Aging, Cellular Senescence, and Osteoporosis
RJ Pignolo, SF Law, A Chandra |
JBMR Plus | 2021 |
|
Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
J Iske, T Matsunaga, H Zhou, SG Tullius |
Frontiers in immunology | 2021 |
|
Role of Cellular Senescence in Type II Diabetes
A Narasimhan, RR Flores, PD Robbins, LJ Niedernhofer |
Endocrinology | 2021 |
|
β cell aging and age-related diabetes
M Zhu, X Liu, W Liu, Y Lu, J Cheng, Y Chen |
Aging | 2021 |
|
Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren’s Syndrome Model Mice
M Kurosawa, Y Shikama, M Furukawa, R Arakaki, N Ishimaru, K Matsushita |
International journal of molecular sciences | 2021 |
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Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema
C Schiffers, LK Lundblad, M Hristova, A Habibovic, CM Dustin, N Daphtary, M Aliyeva, DJ Seward, YM Janssen-Heininger, EF Wouters, NL Reynaert, A van der Vliet |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
|
Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease
S Stucker, JD Angelis, AP Kusumbe |
Frontiers in physiology | 2021 |
|
Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism
M Ito, T Yurube, Y Kanda, Y Kakiuchi, Y Takeoka, T Takada, R Kuroda, K Kakutani |
International journal of molecular sciences | 2021 |
|
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
R Kumari, P Jat |
Frontiers in Cell and Developmental Biology | 2021 |
|
Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications
H Hu, Z Ye, Y Qin, X Xu, X Yu, Q Zhuo, S Ji |
Acta Pharmacologica Sinica | 2021 |
|
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function
A Palmer, S Epton, E Crawley, M Straface, L Gammon, MM Edgar, Y Xu, S Elahi, J Chin-Aleong, JE Martin, CL Bishop, CH Knowles, GJ Sanger |
Frontiers in neuroscience | 2021 |
|
SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias, D Furman, DA Winer, E Verdin |
2021 | |
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Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
D Chanda, M Rehan, SR Smith, KG Dsouza, Y Wang, K Bernard, D Kurundkar, V Memula, K Kojima, JA Mobley, GA Benavides, V Darley-Usmar, YL Kim, JW Zmijewski, JS Deshane, SD Langhe, VJ Thannickal |
eLife | 2021 |
|
Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System
GE Yeo, MH Ng, FB Nordin, JX Law |
International journal of molecular sciences | 2021 |
|
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence
JA López-Domínguez, S Rodríguez-López, U Ahumada-Castro, PY Desprez, M Konovalenko, RM Laberge, C Cárdenas, JM Villalba, J Campisi |
Aging | 2021 |
|
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
PD Robbins, D Jurk, S Khosla, JL Kirkland, NK LeBrasseur, JD Miller, JF Passos, RJ Pignolo, T Tchkonia, LJ Niedernhofer |
Annual Review of Pharmacology and Toxicology | 2021 |
|
Strategies for targeting senescent cells in human disease
NS Gasek, GA Kuchel, JL Kirkland, M Xu |
2021 | |
|
Strategies for late phase preclinical and early clinical trials of senolytics
EO Gerdes, A Misra, JM Netto, T Tchkonia, JL Kirkland |
Mechanisms of Ageing and Development | 2021 |
|
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
W Sun, K Laubach, C Lucchessi, Y Zhang, M Chen, J Zhang, X Chen |
Genes & development | 2021 |
|
Senescence and Aging: Does It Impact Cancer Immunotherapies?
D Maggiorani, C Beauséjour |
Cells | 2021 |
|
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
P Banerjee, S Kotla, LR Velatooru, RJ Abe, EA Davis, JP Cooke, K Schadler, A Deswal, J Herrmann, SH Lin, J Abe, NT Le |
Frontiers in Cardiovascular Medicine | 2021 |
|
CDKN2A Gene Expression as a Potential Aging Biomarker in Dogs
S Sándor, K Tátrai, K Czeibert, B Egyed, E Kubinyi |
Frontiers in Veterinary Science | 2021 |
|
Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
R Ahmed, Y Nakahata, K Shinohara, Y Bessho |
Frontiers in neuroscience | 2021 |
|
Redd1 knockdown prevents doxorubicin-induced cardiac senescence
P Huang, L Bai, L Liu, J Fu, K Wu, H Liu, Y Liu, B Qi, B Qi |
Aging | 2021 |
|
Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment
S Wang, A Prizment, B Thyagarajan, A Blaes |
Cancers | 2021 |
|
Acute kidney injury and aging
M Chang-Panesso |
Pediatric Nephrology | 2021 |
|
Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
YW Choi, YH Kim, SY Oh, KW Suh, YS Kim, GY Lee, JE Yoon, SS Park, YK Lee, YJ Park, HS Kim, SH Park, JH Kim, TJ Park |
Advanced Science | 2021 |
|
Senescence in Post-Mitotic Cells: A Driver of Aging?
T von Zglinicki, T Wan, S Miwa |
Antioxidants & Redox Signaling | 2021 |
|
Measuring Biologic Resilience in Older Cancer Survivors
MS Sedrak, NJ Gilmore, JE Carroll, HB Muss, HJ Cohen, W Dale |
Journal of Clinical Oncology | 2021 |
|
Islet β‐cells physiological difference study of old and young mice based on single‐cell transcriptomics
Z Zheng, Q Zhan, A Chen, Z Yu, G Chen |
Journal of Diabetes Investigation | 2021 |
|
Sleep and biological aging: A short review
JE Carroll, AA Prather |
2021 | |
|
Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice
M Hashimoto, A Goto, Y Endo, M Sugimoto, J Ueda, H Yamashita |
International journal of molecular sciences | 2021 |
|
Breast Cancer and p16: Role in Proliferation, Malignant Transformation and Progression
DV Jovanovic, SL Mitrovic, MZ Milosavljevic, MB Ilic, VD Stankovic, MS Vuletic, MN Stojanovic, DB Milosev, GL Azanjac, VM Nedeljkovic, D Radovanovic |
Healthcare | 2021 |
|
Senolytics: Potential for Alleviating Diabetes and Its Complications
AK Palmer, T Tchkonia, JL Kirkland |
Endocrinology | 2021 |
|
Exosomes and Micro-RNAs in Aging Process
Y Hamdan, L Mazini, G Malka |
Biomedicines | 2021 |
|
Necroptosis contributes to chronic inflammation and fibrosis in aging liver
S Mohammed, N Thadathil, R Selvarani, EH Nicklas, D Wang, BF Miller, A Richardson, SS Deepa |
Aging Cell | 2021 |
|
Frailty, aging, and periodontal disease: Basic biologic considerations
D Clark, E Kotronia, S Ramsay |
Periodontology 2000 | 2021 |
|
Mesenchymal Stem Cell Senescence and Osteogenesis
A Tjempakasari, H Suroto, D Santoso |
Medicina | 2021 |
|
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
K Wilson, M Chamoli, T Hilsabeck, M Pandey, S Bansal, G Chawla, P Kapahi |
Cell Metabolism | 2021 |
|
Cellular Senescence in Adrenocortical Biology and Its Disorders
X Gao, F Li, B Liu, Y Wang, Y Wang, H Zhou |
Cells | 2021 |
|
Mechanisms and Regulation of Cellular Senescence
L Roger, F Tomas, V Gire |
International journal of molecular sciences | 2021 |
|
Protocol for assessing senescence-associated lung pathologies in mice
K Kawaguchi, M Hashimoto, R Mikawa, A Asai, T Sato, M Sugimoto |
2021 | |
|
GH and Senescence: A New Understanding of Adult GH Action
V Chesnokova, S Melmed |
Journal of the Endocrine Society | 2021 |
|
Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19.
de Moraes D, Paiva BVB, Cury SS, Ludwig RG, Junior JPA, Mori MADS, Carvalho RF |
Aging and disease | 2021 |
|
Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging.
Wang Q, Nie L, Zhao P, Zhou X, Ding Y, Chen Q, Wang Q |
International Journal of Oral Science | 2021 |
|
Transcriptomic Analysis of Cellular Senescence: One Step Closer to Senescence Atlas.
Kim S, Kim C |
Molecules and Cells | 2021 |
|
Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice.
Urate S, Wakui H, Azushima K, Yamaji T, Suzuki T, Abe E, Tanaka S, Taguchi S, Tsukamoto S, Kinguchi S, Uneda K, Kanaoka T, Atobe Y, Funakoshi K, Yamashita A, Tamura K |
International journal of molecular sciences | 2021 |
|
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
Jiang TX, Ma S, Han X, Luo ZY, Zhu QQ, Chiba T, Xie W, Lin K, Qiu XB |
Theranostics | 2021 |
|
Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells
Mehta IS, Riyahi K, Pereira RT, Meaburn KJ, Figgitt M, Kill IR, Eskiw CH, Bridger JM |
Frontiers in Cell and Developmental Biology | 2021 |
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Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution
Ramos\u2010Marquès E, García\u2010Mendívil L, Pérez\u2010Zabalza M, Santander\u2010Badules H, Srinivasan S, Oliveros JC, Torres\u2010Pérez R, Cebollada A, Vallejo\u2010Gil JM, Fresneda\u2010Roldán PC, Fañanás\u2010Mastral J, Vázquez\u2010Sancho M, Matamala\u2010Adell M, Sorribas\u2010Berjón JF, Bellido\u2011Morales JA, Mancebón\u2011Sierra FJ, Vaca\u2011Núñez AS, Ballester\u2010Cuenca C, Jiménez\u2010Navarro M, Villaescusa JM, Garrido\u2010Huéscar E, Segovia\u2010Roldán M, Oliván\u2010Viguera A, Gómez\u2010González C, Muñiz G, Diez E, Ordovás L, Pueyo E |
Aging Cell | 2021 |
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Identification of Biochemical and Molecular Markers of Early Aging in Childhood Cancer Survivors
Ravera S, Vigliarolo T, Bruno S, Morandi F, Marimpietri D, Sabatini F, Dagnino M, Petretto A, Bartolucci M, Muraca M, Biasin E, Haupt R, Zecca M, Fagioli F, Cilloni D, Podestà M, Frassoni F |
Cancers | 2021 |
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Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury
Lim S, Kim TJ, Kim YJ, Kim C, Ko SB, Kim BS |
International journal of molecular sciences | 2021 |
|
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O\u2019Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SP, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ |
Nature | 2021 |
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Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513
Kiel C, Strunz T, Hasler D, Meister G, Grassmann F, Weber BH |
Human Molecular Genetics | 2021 |
|
Potential of the cell-free blood-based biomarker uroplakin 2 RNA to detect recurrence after surgical resection of lung adenocarcinoma.
Zhu J, Lu Q, Li B, Li H, Wu C, Li C, Jin H |
Oncology Letters | 2021 |
|
Human disease biomarker panels through systems biology
Smith BJ, Silva-Costa LC, Martins-de-Souza D |
Biophysical Reviews | 2021 |
|
Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation
Wyles SP, Tchkonia T, Kirkland JL |
Plastic and Reconstructive Surgery | 2021 |
|
Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care
Thompson EL, Pitcher LE, Niedernhofer LJ, Robbins PD |
Plastic and Reconstructive Surgery | 2021 |
|
The Senescence-Associated Secretome as an Indicator of Age and Medical Risk
Marissa J. Schafer, Xu Zhang, Amanika Kumar, Elizabeth J. Atkinson, Yi Zhu, Sarah Jachim, Daniel L. Mazula, Ashley K. Brown, Michelle J. Berning, Zaira Aversa, Brian Kotajarvi, Charles Bruce, Kevin L. Greason, Rakesh M. Suri, Russell P. Tracy, Steven Cummings, Thomas A. White, Nathan LeBrasseur |
JCI Insight | 2020 |
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Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
H Sugihara, N Teramoto, K Nakamura, T Shiga, T Shirakawa, M Matsuo, M Ogasawara, I Nishino, T Matsuwaki, M Nishihara, K Yamanouchi |
Scientific Reports | 2020 |
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
J Iske, M Seyda, T Heinbokel, R Maenosono, K Minami, Y Nian, M Quante, CS Falk, H Azuma, F Martin, JF Passos, CU Niemann, T Tchkonia, JL Kirkland, A Elkhal, SG Tullius |
Nature Communications | 2020 |
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Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
PR Coryell, BO Diekman, RF Loeser |
Nature Reviews Rheumatology | 2020 |
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The Effects of Continuous and Withdrawal Voluntary Wheel Running Exercise on the Expression of Senescence-Related Genes in the Visceral Adipose Tissue of Young Mice
M Kimura, S Suzuki, A Moriya, K Nogami, R Uchida, Y Saito, H Saito |
International journal of molecular sciences | 2020 |
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Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment
J Riegger, RE Brenner |
International journal of molecular sciences | 2020 |
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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions
MH Docherty, DP Baird, J Hughes, DA Ferenbach |
Frontiers in pharmacology | 2020 |
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Cellular senescence in age-related disorders
J Kaur, JN Farr |
Translational research : the journal of laboratory and clinical medicine | 2020 |
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Cellular senescence and Alzheimer disease: the egg and the chicken scenario
S Saez-Atienzar, E Masliah |
Nature Reviews Neuroscience | 2020 |
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The role of cellular senescence in ageing and endocrine disease
S Khosla, JN Farr, T Tchkonia, JL Kirkland |
Nature Reviews Endocrinology | 2020 |
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Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
L Wyld, I Bellantuono, T Tchkonia, J Morgan, O Turner, F Foss, J George, S Danson, JL Kirkland |
Cancers | 2020 |
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The ageing kidney: molecular mechanisms and clinical implications
Y Fang, AY Gong, ST Haller, LD Dworkin, Z Liu, R Gong |
Ageing Research Reviews | 2020 |
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Autophagy and mTOR signaling during intervertebral disc aging and degeneration
T Yurube, M Ito, Y Kakiuchi, R Kuroda, K Kakutani |
2020 | |
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Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
W Venturini, A Olate-Briones, C Valenzuela, D Méndez, E Fuentes, A Cayo, D Mancilla, R Segovia, NE Brown, R Moore-Carrasco |
International journal of molecular sciences | 2020 |
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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
J Xu, L Zhou, Y Liu |
Frontiers in pharmacology | 2020 |
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Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors
L Lefèvre, JS Iacovoni, H Martini, J Bellière, D Maggiorani, M Dutaur, DJ Marsal, P Decaunes, N Pizzinat, J Mialet-Perez, D Cussac, A Parini, V Douin-Echinard |
Cellular and Molecular Life Sciences | 2020 |
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
RD Micco, V Krizhanovsky, D Baker, F dAdda di Fagagna |
Nature Reviews Molecular Cell Biology | 2020 |
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Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
N Azazmeh, B Assouline, E Winter, S Ruppo, Y Nevo, A Maly, K Meir, AK Witkiewicz, J Cohen, SV Rizou, E Pikarsky, C Luxenburg, VG Gorgoulis, I Ben-Porath |
Nature Communications | 2020 |
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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
MJ Yousefzadeh, J Zhao, C Bukata, EA Wade, SJ McGowan, LA Angelini, MP Bank, AU Gurkar, CA McGuckian, MF Calubag, JI Kato, CE Burd, PD Robbins, LJ Niedernhofer |
Aging Cell | 2020 |
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Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy
MD Martino, M Tkach, S Bruni, D Rocha, MF Mercogliano, ME Cenciarini, MF Chervo, CJ Proietti, F Dingli, D Loew, EA Fernández, PV Elizalde, E Piaggio, R Schillaci |
OncoImmunology | 2020 |
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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Y Fan, J Cheng, H Zeng, L Shao |
Frontiers in physiology | 2020 |
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Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
IS Pyo, S Yun, YE Yoon, JW Choi, SJ Lee |
Molecules (Basel, Switzerland) | 2020 |
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The emerging role of cellular senescence in renal diseases
B Zhou, Y Wan, R Chen, C Zhang, X Li, F Meng, S Glaser, N Wu, T Zhou, S Li, H Francis, G Alpini, P Zou |
Journal of Cellular and Molecular Medicine | 2020 |
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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
S Song, EW Lam, T Tchkonia, JL Kirkland, Y Sun |
Trends in Biochemical Sciences | 2020 |
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Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
MJ Yousefzadeh, JE Wilkinson, B Hughes, N Gadela, WC Ladiges, N Vo, LJ Niedernhofer, DM Huffman, PD Robbins |
GeroScience | 2020 |
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Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast
YC Yu, TZ Hui, TH Kao, HF Liao, CY Yang, CC Hou, HT Hsieh, JY Chang, YT Tsai, M Pinskaya, KC Yang, YR Chen, A Morillon, MH Tsai, SP Lin |
Frontiers in Cell and Developmental Biology | 2020 |
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Discovery, development, and future application of senolytics: theories and predictions
EO Gerdes, Y Zhu, T Tchkonia, JL Kirkland |
The FEBS journal | 2020 |
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Ileal Transposition Increases Pancreatic β Cell Mass and Decreases β Cell Senescence in Diet-Induced Obese Rats
CH Ahn, EH Choi, TJ Oh, YM Cho |
Obesity Surgery | 2020 |
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Senescent cells and macrophages: key players for regeneration?
S S., E Emmerson |
Open Biology | 2020 |
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New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms
T Tchkonia, AK Palmer, JL Kirkland |
The Journal of clinical endocrinology and metabolism | 2020 |
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Functional changes in beta cells during ageing and senescence
C Aguayo-Mazzucato |
Diabetologia | 2020 |
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The Emerging Role of Senescence in Ocular Disease
PG Sreekumar, DR Hinton, R Kannan |
Oxidative medicine and cellular longevity | 2020 |
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Survey of senescent cell markers with age in human tissues
ML Idda, WG McClusky, V Lodde, R Munk, K Abdelmohsen, M Rossi, M Gorospe |
Aging | 2020 |
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A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
M Wakita, A Takahashi, O Sano, TM Loo, Y Imai, M Narukawa, H Iwata, T Matsudaira, S Kawamoto, N Ohtani, T Yoshimori, E Hara |
Nature Communications | 2020 |
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Histone demethylase Jumonji domain‐containing 1A inhibits proliferation and progression of gastric cancer by upregulating runt‐related transcription factor 3
K Ning, Y Shao, Y He, F Wang, , F Liu, D Li, F Li |
Cancer Science | 2020 |
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Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Y Cai, H Zhou, Y Zhu, Q Sun, Y Ji, A Xue, Y Wang, W Chen, X Yu, L Wang, H Chen, C Li, T Luo, H Deng |
Cell Research | 2020 |
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Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases
A Salminen |
Journal of Molecular Medicine | 2020 |
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Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence
E Bae, JH Kim, MH Jung, SJ Jang, TW Lee, S Jung, S Lee, HN Jang, SH Chang, DJ Park, R Braun |
Oxidative Medicine & Cellular Longevity | 2020 |
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Hypoxia Pretreatment Promotes Chondrocyte Differentiation of Human Adipose-Derived Stem Cells via Vascular Endothelial Growth Factor
OK Hwang, YW Noh, JT Hong, JW Lee |
Tissue Engineering and Regenerative Medicine | 2020 |
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Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
S Song, T Tchkonia, J Jiang, JL Kirkland, Y Sun |
Advanced Science | 2020 |
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Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
ME Maï, M Marzullo, IP de Castro, MG Ferreira |
eLife | 2020 |
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Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study
C Martin-Ruiz, CH Williams-Gray, AJ Yarnall, JJ Boucher, RA Lawson, RS Wijeyekoon, RA Barker, C Kolenda, C Parker, DJ Burn, TV Zglinicki, G Saretzki |
Journal of Parkinson's disease | 2020 |
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Effects of Breast Cancer Adjuvant Chemotherapy Regimens on Expression of the Aging Biomarker, p16INK4a
SS Shachar, AM Deal, KE Reeder-Hayes, KA Nyrop, N Mitin, CK Anders, LA Carey, EC Dees, TA Jolly, GG Kimmick, MS Karuturi, RE Reinbolt, JE Speca, HB Muss |
2020 | |
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p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction
R Mikawa, T Sato, Y Suzuki, H Baskoro, K Kawaguchi, M Sugimoto |
Biomolecules | 2020 |
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Senolytic drugs: from discovery to translation
JL Kirkland, T Tchkonia |
Journal of Internal Medicine | 2020 |
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T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma
F Lucas, M Pennell, Y Huang, DM Benson, YA Efebera, M Chaudhry, T Hughes, JA Woyach, JC Byrd, S Zhang, D Jones, X Guan, CE Burd, AE Rosko |
Biology of Blood and Marrow Transplantation | 2020 |
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The Ercc 1 -/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions
A Wong, T Kieu, PD Robbins |
Aging | 2020 |
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Stimulation of epidermal hyperplasia and tumorigenesis by resident p16 INK4a -expressing cells
N Azazmeh, I Ben-Porath |
Molecular & Cellular Oncology | 2020 |
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p16 a biomarker of aging and tolerance for cancer therapy
H Muss, A Smitherman, W Wood, K Nyrop, S Tuchman, P Randhawa, A Entwistle, N Mitin, S Shachar |
Translational cancer research | 2020 |
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The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
R Wallis, H Mizen, CL Bishop |
Mechanisms of Ageing and Development | 2020 |
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Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells
Bai L, Lyu Y, Shi G, Li K, Huang Y, Ma Y, Cong YS, Zhang L, Qin C |
Aging | 2020 |
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Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
Ansere VA, Ali-Mondal S, Sathiaseelan R, Garcia DN, Isola JV, Henseb JD, Saccon TD, Ocañas SR, Tooley KB, Stout MB, Schneider A, Freeman WM |
Mechanisms of Ageing and Development | 2020 |
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Multiparameter flow cytometric detection and quantification of senescent cells in vitro.
Adewoye AB, Tampakis D, Follenzi A, Stolzing A |
Biogerontology | 2020 |
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Histone methyltransferase Smyd3 is a new regulator for vascular senescence.
Yang D, Wei G, Long F, Nie H, Tian X, Qu L, Wang S, Li P, Qiu Y, Wang Y, Hong W, Ni T, Liu X, Zhu YZ |
Aging Cell | 2020 |
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Transcriptome analysis reveals the difference between “healthy” and “common” aging and their connection with age‐related diseases
Zeng L, Yang J, Peng S, Zhu J, Zhang B, Suh Y, Tu Z |
Aging Cell | 2020 |
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Autophagy regulates the localization and degradation of p16INK4a
Coryell PR, Goraya SK, Griffin KA, Redick MA, Sisk SR, Purvis JE |
Aging Cell | 2020 |
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Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control
Cavinato M, Madreiter\u2010Sokolowski CT, Büttner S, Schosserer M, Zwerschke W, Wedel S, Grillari J, Graier WF, Jansen\u2010Dürr P |
The FEBS journal | 2020 |
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Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
Yang CY, Chanalaris A, Bonelli S, McClurg O, Hiles GL, Cates AL, Zarebska JM, Vincent TL, Day ML, Müller SA, Lichtenthaler SF, Nagase H, Scilabra SD, Troeberg L |
2020 | |
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Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice.
Dai X, Hong L, Shen H, Du Q, Ye Q, Chen X, Zhang J |
Aging | 2020 |
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Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.
Zheng S, Zheng H, Huang A, Mai L, Huang X, Hu Y, Huang Y |
International journal of medical sciences | 2020 |
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Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).
Baliou S, Kyriakopoulos AM, Goulielmaki M, Panayiotidis MI, Spandidos DA, Zoumpourlis V |
Molecular medicine reports | 2020 |
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1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis
R Yang, J Chen, J Zhang, R Qin, R Wang, Y Qiu, Z Mao, D Goltzman, D Miao |
Aging Cell | 2019 |
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Premature aging and cancer development in transgenic mice lacking functional CYLD
JP Alameda, Á Ramírez, RA García-Fernández, M Navarro, A Page, JC Segovia, R Sanchez, C Suárez-Cabrera, JM Paramio, A Bravo, MJ Fernández-Aceñero, ML Casanova |
Aging | 2019 |
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Cellular Senescence: Methods and Protocols
M Demaria |
2019 | |
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Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans
JN Farr, JL Rowsey, BA Eckhardt, BS Thicke, DG Fraser, T Tchkonia, JL Kirkland, DG Monroe, S Khosla |
Journal of Bone and Mineral Research | 2019 |
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Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum
KH Kim, Y Cho, J Lee, H Jeong, Y Lee, SI Kim, CH Kim, HW Lee, KT Nam |
Scientific Reports | 2019 |
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Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging
T Mau, M OBrien, AK Ghosh, RA Miller, R Yung, DL Couteur |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2019 |
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, SK Hashmi, L Prata, MM Masternak, SB Kritchevsky, N Musi, JL Kirkland |
EBioMedicine | 2019 |
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p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
MH Yoon, S Kang, SJ Lee, TG Woo, AY Oh, S Park, NC Ha, BJ Park |
Cell Death and Disease | 2019 |
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Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?
E Cianflone, M Torella, C Chimenti, AD Angelis, AP Beltrami, K Urbanek, M Rota, D Torella |
Oxidative medicine and cellular longevity | 2019 |
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Cellular senescence in bone
JN Farr, S Khosla |
Bone | 2019 |
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Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice
JE Hajjar, W Chatoo, R Hanna, P Nkanza, N Tétreault, YC Tse, TP Wong, M Abdouh, G Bernier |
Scientific Reports | 2019 |
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Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence
JY Liu, GP Souroullas, BO Diekman, J Krishnamurthy, BM Hall, JA Sorrentino, JS Parker, GA Sessions, AV Gudkov, NE Sharpless |
Proceedings of the National Academy of Sciences | 2019 |
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Targeting Cell Senescence for the Treatment of Age-Related Bone Loss
RJ Pignolo, RM Samsonraj, SF Law, H Wang, A Chandra |
Current Osteoporosis Reports | 2019 |
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Astrocyte senescence: Evidence and significance
J Cohen, C Torres |
Aging Cell | 2019 |
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Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging
M Strickland, B Yacoubi-Loueslati, B Bouhaouala-Zahar, SL Pender, A Larbi |
Frontiers in physiology | 2019 |
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Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time
R Ahmed, A Ashimori, S Iwamoto, T Matsui, Y Nakahata, Y Bessho |
Aging | 2019 |
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Aged-senescent cells contribute to impaired heart regeneration
FC Lewis-McDougall, PJ Ruchaya, E Domenjo-Vila, TS Teoh, L Prata, BJ Cottle, JE Clark, PP Punjabi, W Awad, D Torella, T Tchkonia, JL Kirkland, GM Ellison-Hughes |
Aging Cell | 2019 |
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Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes following acute traumatic brain injury in mice
RM Ritzel, SJ Doran, EP Glaser, VE Meadows, AI Faden, BA Stoica, DJ Loane |
Neurobiology of Aging | 2019 |
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Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
C Aguayo-Mazzucato, J Andle, TB Lee, A Midha, L Talemal, V Chipashvili, J Hollister-Lock, J van Deursen, G Weir, S Bonner-Weir |
Cell Metabolism | 2019 |
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Senescent cells in the development of cardiometabolic disease:
AC Postmus, I Sturmlechner, JW Jonker, JM van Deursen, B van de Sluis, JK Kruit |
Current Opinion in Lipidology | 2019 |
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Methylation-Based Biological Age and Breast Cancer Risk
JK Kresovich, Z Xu, KM OBrien, CR Weinberg, DP Sandler, JA Taylor |
JNCI Journal of the National Cancer Institute | 2019 |
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Cellular senescence in the lung across the age spectrum
P Parikh, S Wicher, K Khandalavala, CM Pabelick, RD Britt, YS Prakash |
American journal of physiology. Lung cellular and molecular physiology | 2019 |
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Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
L Palacio, ML Goyer, D Maggiorani, A Espinosa, N Villeneuve, S Bourbonnais, G MoquinBeaudry, O Le, M Demaria, AR Davalos, H Decaluwe, C Beauséjour |
Aging Cell | 2019 |
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Are skin senescence and immunosenescence linked within individuals?
ME Waaijer, D Goldeck, DA Gunn, D Heemst, RG Westendorp, G Pawelec, AB Maier |
Aging Cell | 2019 |
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1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
L Chen, R Yang, W Qiao, W Zhang, J Chen, L Mao, D Goltzman, D Miao |
Aging Cell | 2019 |
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Reprogramming the Epigenome With Vitamin C
TL Chong, EL Ahearn, L Cimmino |
Frontiers in Cell and Developmental Biology | 2019 |
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Hepatic senescence, the good and the bad
N Huda, G Liu, H Hong, S Yan, B Khambu, XM Yin |
World journal of gastroenterology : WJG | 2019 |
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
LT Hickson, LG Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, SM Herrmann, MD Jensen, Q Jia, KL Jordan, TA Kellogg, S Khosla, DM Koerber, AB Lagnado, DK Lawson, NK LeBrasseur, LO Lerman, KM McDonald, TJ McKenzie, JF Passos, RJ Pignolo, T Pirtskhalava, IM Saadiq, KK Schaefer, SC Textor, SG Victorelli, TL Volkman, A Xue, MA Wentworth, EO Gerdes, Y Zhu, T Tchkonia, JL Kirkland |
EBioMedicine | 2019 |
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Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
S Sándor, E Kubinyi |
Frontiers in Genetics | 2019 |
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Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure
A Khalyfa, JM Marin, Z Qiao, DS Rubio, L Kheirandish-Gozal, D Gozal |
Sleep | 2019 |
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The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease
J Papaconstantinou |
Cells | 2019 |
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Breast cancer treatment and its effects on aging
L Chang, LS Weiner, SJ Hartman, S Horvath, D Jeste, PS Mischel, DM Kado |
Journal of Geriatric Oncology | 2019 |
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Controlled induction and targeted elimination of p16 INK4a ‐expressing chondrocytes in cartilage explant culture
GA Sessions, ME Copp, JY Liu, MA Sinkler, S D'Costa, BO Diekman |
The FASEB Journal | 2019 |
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LncRNAs Regulatory Networks in Cellular Senescence.
Puvvula PK |
International journal of molecular sciences | 2019 |
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Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling.
Pi C, Yang Y, Sun Y, Wang H, Sun H, Ma M, Lin L, Shi Y, Li Y, Li Y, He X |
Aging | 2019 |
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CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD+/Sirt1 Signaling Pathway.
Wang LF, Cao Q, Wen K, Xiao YF, Chen TT, Guan XH, Liu Y, Zuo L, Qian YS, Deng KY, Xin HB |
Frontiers in physiology | 2019 |
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Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.
Billard P, Poncet DA |
International journal of molecular sciences | 2019 |
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Survival of aging CD264+ and CD264- populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.
Madsen SD, Jones SH, Tucker HA, Giler MK, Muller DC, Discher CT, Russell KC, Dobek GL, Sammarco MC, Bunnell BA, O'Connor KC |
Biotechnology and Bioengineering | 2019 |
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New Insights into Chronological Mobility of Retrotransposons In Vivo.
Ghanam AR, Cao J, Ouyang X, Song X |
Oxidative medicine and cellular longevity | 2019 |
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The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
Cayuela ML, Claes KB, Ferreira MG, Henriques CM, van Eeden F, Varga M, Vierstraete J, Mione MC |
Frontiers in Cell and Developmental Biology | 2019 |
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p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise
Micheli L, D\u2019Andrea G, Ceccarelli M, Ferri A, Scardigli R, Tirone F |
Frontiers in cellular neuroscience | 2019 |
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TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway
Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW |
Journal of Translational Medicine | 2019 |
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Serum and nutrient deprivation increases autophagic flux in intervertebral disc annulus fibrosus cells: an in-vitro experimental study
Yurube T, Buchser WJ, Moon HJ, Hartman RA, Takayama K, Kawakami Y, Nishida K, Kurosaka M, Vo NV, Kang JD, Lotze MT, Sowa GA |
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society | 2019 |
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p16INK4A-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation
Chikenji TS, Saito Y, Konari N, Nakano M, Mizue Y, Otani M, Fujimiya M |
EBioMedicine | 2019 |
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Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice
Yzydorczyk C, Li N, Rigal E, Chehade H, Mosig D, Armengaud JB, Rolle T, Krishnasamy A, Orozco E, Siddeek B, Juvet C, Vergely C, Simeoni U |
Nutrients | 2019 |
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mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts
Wu S, Xu S, Li R, Li K, Zhong X, Li Y, Zhou Z, Liu Y, Feng R, Zheng J, Songyang Z, Liu F |
Frontiers in Cell and Developmental Biology | 2019 |
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Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers
Lim J, Bang S, Kim J, Park C, Cho J, Kim S |
Computational and mathematical methods in medicine | 2019 |
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Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis
Tuttle CS, Waaijer ME, Slee\u2010Valentijn MS, Stijnen T, Westendorp R, Maier AB |
Aging Cell | 2019 |
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Autologous decellularized extracellular matrix protects against H2O2-induced senescence and aging in adipose-derived stem cells and stimulates proliferation in vitro
Yu X, He Y, Chen Z, Qian Y, Wang J, Ji Z, Tan X, Li L, Lin M |
Bioscience Reports | 2019 |
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Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance
Unthank JL, Ortiz M, Trivedi H, Pelus LM, Sampson CH, Sellamuthu R, Fisher A, Chua HL, Plett A, Orschell CM, Cohen EP, Miller SJ |
Radiation Research | 2019 |
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The untapped potential of reptile biodiversity for understanding how and why animals age
Hoekstra LA, Schwartz TS, Sparkman AM, Miller DA, Bronikowski AM |
Functional Ecology | 2019 |
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Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
Ronald Petersen, Darren Baker |
Journal of Clinical Investigation | 2018 |
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Senescent cells: A therapeutic target for cardiovascular disease
Bennett Childs, Hu Li, Jan van Deursen |
Journal of Clinical Investigation | 2018 |
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Mechanisms of cellular senescence
Nicolás Herranz, Jesus Gil |
Journal of Clinical Investigation | 2018 |
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Senescent cells and osteoarthritis: a painful connection
Ok Hee Jeon, Nathaniel David, Judith Campisi, Jennifer H. Elisseeff |
Journal of Clinical Investigation | 2018 |
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Role of sphingolipids in senescence: implication in aging and age-related diseases
Magali Trayssac, Yusuf Hannun, Lina Obeid |
Journal of Clinical Investigation | 2018 |
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Yeast as a tool to identify anti-aging compounds
A Zimmermann, S Hofer, T Pendl, K Kainz, F Madeo, D Carmona-Gutierrez |
FEMS Yeast Research | 2018 |
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Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis
C Vinatier, E Domínguez, J Guicheux, B Caramés |
Frontiers in physiology | 2018 |
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Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
IM Rea, DS Gibson, V McGilligan, SE McNerlan, HD Alexander, OA Ross |
Frontiers in immunology | 2018 |
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The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging: THE HALLMARKS OF SKELETAL AGING
JN Farr, M Almeida |
Journal of Bone and Mineral Research | 2018 |
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The Rbm38-p63 feedback loop is critical for tumor suppression and longevity
Y Jiang, E Xu, J Zhang, M Chen, E Flores, X Chen |
Oncogene | 2018 |
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Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema
IK Sundar, K Rashid, J Gerloff, D Li, I Rahman |
American journal of respiratory cell and molecular biology | 2018 |
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Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging
JB Lin, A Sene, A Santeford, H Fujiwara, R Sidhu, MM Ligon, VA Shankar, N Ban, IU Mysorekar, DS Ory, RS Apte |
EBioMedicine | 2018 |
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Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema
K Rashid, IK Sundar, J Gerloff, D Li, I Rahman |
Scientific Reports | 2018 |
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Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response
M Chang-Panesso, FF Kadyrov, FG Machado, A Kumar, BD Humphreys |
American journal of physiology. Renal physiology | 2018 |
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T 3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells
C Aguayo-Mazzucato, TB Lee, M Matzko, A DiIenno, H Rezanejad, P Ramadoss, T Scanlan, AM Zavacki, PR Larsen, A Hollenberg, C Colton, A Sharma, S Bonner-Weir |
Diabetes | 2018 |
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Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification
M Alique, R Ramírez-Carracedo, G Bodega, J Carracedo, R Ramírez |
International journal of molecular sciences | 2018 |
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Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations
MJ Schafer, AJ Haak, DJ Tschumperlin, NK LeBrasseur |
Current Rheumatology Reports | 2018 |
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Acute Kidney Injury as a Condition of Renal Senescence
L Andrade, CE Rodrigues, SA Gomes, IL Noronha |
Cell Transplantation | 2018 |
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Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
M Malavolta, M Bracci, L Santarelli, A Sayeed, E Pierpaoli, R Giacconi, L Costarelli, F Piacenza, A Basso, M Cardelli, M Provinciali |
Mediators of Inflammation | 2018 |
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Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice
AD Hudgins, C Tazearslan, A Tare, Y Zhu, D Huffman, Y Suh |
Frontiers in Genetics | 2018 |
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Expression of p16 INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis
BO Diekman, GA Sessions, JA Collins, AK Knecht, SL Strum, NK Mitin, CS Carlson, RF Loeser, NE Sharpless |
Aging Cell | 2018 |
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INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice
O Le, L Palacio, G Bernier, I Batinic-Haberle, G Hickson, C Beauséjour |
Stem Cell Reports | 2018 |
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High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats
X Zhang, GB Xu, D Zhou, YX Pan |
Genes & Nutrition | 2018 |
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Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
S Oja, P Komulainen, A Penttilä, J Nystedt, M Korhonen |
Stem Cell Research & Therapy | 2018 |
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Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas
T Cindrova-Davies, NM Fogarty, CJ Jones, J Kingdom, GJ Burton |
Placenta | 2018 |
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Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells
C Göbel, R Goetzke, T Eggermann, W Wagner |
Scientific Reports | 2018 |
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Biomarkers of Cellular Senescence and Skin Aging
AS Wang, O Dreesen |
Frontiers in Genetics | 2018 |
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Mangiferin induces islet regeneration in aged mice through regulating p16INK4a
H Wang, X He, T Lei, Y Liu, G Huai, M Sun, S Deng, H Yang, R Tong, Y Wang |
International journal of molecular medicine | 2018 |
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Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system
R Kehm, J König, K Nowotny, T Jung, S Deubel, S Gohlke, TJ Schulz, A Höhn |
Redox Biology | 2018 |
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miR-200a Modulates the Expression of the DNA Repair Protein OGG1 Playing a Role in Aging of Primary Human Keratinocytes
L Tinaburri, M DErrico, S Sileno, R Maurelli, P Degan, A Magenta, E Dellambra |
Oxidative medicine and cellular longevity | 2018 |
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Ageing, Cellular Senescence and Neurodegenerative Disease
M Kritsilis, SV Rizou, P Koutsoudaki, K Evangelou, V Gorgoulis, D Papadopoulos |
International journal of molecular sciences | 2018 |
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Fisetin is a senotherapeutic that extends health and lifespan
MJ Yousefzadeh, Y Zhu, SJ McGowan, L Angelini, H Fuhrmann-Stroissnigg, M Xu, YY Ling, KI Melos, T Pirtskhalava, CL Inman, C McGuckian, EA Wade, JI Kato, D Grassi, M Wentworth, CE Burd, EA Arriaga, WL Ladiges, T Tchkonia, JL Kirkland, PD Robbins, LJ Niedernhofer |
EBioMedicine | 2018 |
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Elimination of p19 ARF -expressing cells protects against pulmonary emphysema in mice
R Mikawa, Y Suzuki, H Baskoro, K Kanayama, K Sugimoto, T Sato, M Sugimoto |
Aging Cell | 2018 |
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Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
D Orioli, E Dellambra |
Cells | 2018 |
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Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line
C Jiang, X Liu, C Li, H Qian, D Chen, C Lai, L Shen |
Journal of Zhejiang University SCIENCE B | 2018 |
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Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation
M Adorno, BN di Robilant, SS Sikandar, VH Acosta, J Antony, CH Heller, MF Clarke |
Scientific Reports | 2018 |
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CpG Island Methylation Patterns in Relapsing-Remitting Multiple Sclerosis
M Sokratous, E Dardiotis, E Bellou, Z Tsouris, A Michalopoulou, M Dardioti, V Siokas, D Rikos, A Tsatsakis, L Kovatsi, DP Bogdanos, GM Hadjigeorgiou |
Journal of Molecular Neuroscience | 2018 |
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Effects of aging and comorbidities on nutritional status and muscle dysfunction in patients with COPD
BP Dubé, P Laveneziana |
Journal of Thoracic Disease | 2018 |
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Cellular Metabolism and Aging
Catic A |
Progress in molecular biology and translational science | 2018 |
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The role of DNA methylation in epigenetics of aging.
Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A |
Pharmacology & Therapeutics | 2018 |
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Brain age from the electroencephalogram of sleep.
Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB |
Neurobiology of Aging | 2018 |
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Cellular senescence induces replication stress with almost no affect on DNA replication timing
Rivera-Mulia JC, Schwerer H, Besnard E, Desprat R, Trevilla-Garcia C, Sima J, Bensadoun P, Zouaoui A, Gilbert DM, Lemaitre JM |
Cell cycle (Georgetown, Tex.) | 2018 |
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Aberrant expression of p16INK4a in human cancers - a new biomarker?
Inoue K, Fry EA |
Cancer reports and reviews | 2018 |
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Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging.
Vilas JM, Carneiro C, Da Silva-Álvarez S, Ferreirós A, González P, Gómez M, Ortega S, Serrano M, García-Caballero T, González-Barcia M, Vidal A, Collado M |
Aging Cell | 2018 |
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Foxp1 controls cell fate commitment and senescence of mesenchymal stem cells during skeletal aging
Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, baojie li, Ying Fan, Zhenlin Zhang, Yang Hong, GONG YANG, Ting-ting Tang, Yongxin Ren, Haley Tucker, Zhengju Yao, Xizhi Guo |
Journal of Clinical Investigation | 2017 |
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Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis
JY Leung, HL Wilson, KJ Voltzke, LA Williams, HJ Lee, SE Wobker, WY Kim |
Molecular and cellular biology | 2017 |
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Identification of HSP90 inhibitors as a novel class of senolytics
H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, Y Zhu, RW Brooks, D Grassi, SQ Gregg, JL Stripay, A Dorronsoro, L Corbo, P Tang, C Bukata, N Ring, M Giacca, X Li, T Tchkonia, JL Kirkland, LJ Niedernhofer, PD Robbins |
Nature Communications | 2017 |
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Molecular and physiological manifestations and measurement of aging in humans
SS Khan, BD Singer, DE Vaughan |
Aging Cell | 2017 |
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Cellular senescence in osteoarthritis pathology
K McCulloch, GJ Litherland, TS Rai |
Aging Cell | 2017 |
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Environmental Chemicals and Aging
BL Pearson, D Ehninger |
Current Environmental Health Reports | 2017 |
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A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence
Y Zhang, A Unnikrishnan, SS Deepa, Y Liu, Y Li, Y Ikeno, D Sosnowska, HV Remmen, A Richardson |
Redox Biology | 2017 |
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Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1
C Ma, C Pi, Y Yang, L Lin, Y Shi, Y Li, Y Li, X He, AP Beltrami |
PloS one | 2017 |
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Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice
JH Kim, BR Lee, ES Choi, KM Lee, SK Choi, JH Cho, WB Jeon, E Kim |
Molecular Therapy - Nucleic Acids | 2017 |
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Increased Arf/p53 activity in stem cells, aging and cancer
E Carrasco-Garcia, M Moreno, L Moreno-Cugnon, A Matheu |
Aging Cell | 2017 |
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Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
V Rapisarda, M Borghesan, V Miguela, V Encheva, AP Snijders, A Lujambio, A OLoghlen |
Cell Reports | 2017 |
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
MP Baar, RM Brandt, DA Putavet, JD Klein, KW Derks, BR Bourgeois, S Stryeck, Y Rijksen, H Willigenburg, DA Feijtel, I der Pluijm, J Essers, WA van Cappellen, WF van IJcken, AB Houtsmuller, J Pothof, RW de Bruin, T Madl, JH Hoeijmakers, J Campisi, PL de Keizer |
Cell | 2017 |
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Senotherapy: growing old and staying young?
R Schmitt |
Pflügers Archiv - European Journal of Physiology | 2017 |
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β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
C Aguayo-Mazzucato, M Haaren, M Mruk, TB Lee, C Crawford, J Hollister-Lock, BA Sullivan, JW Johnson, A Ebrahimi, JM Dreyfuss, JV Deursen, GC Weir, S Bonner-Weir |
Cell Metabolism | 2017 |
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Cellular Senescence: A Translational Perspective
JL Kirkland, T Tchkonia |
EBioMedicine | 2017 |
|
Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells
X Chen, M Li, J Yan, T Liu, G Pan, H Yang, M Pei, F He |
Alcohol and Alcoholism | 2017 |
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A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC
L Samaraweera, A Adomako, A Rodriguez-Gabin, HM McDaid |
Scientific Reports | 2017 |
|
Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
D Nayak, A Kumar, S Chakraborty, R Rasool, H Amin, A Katoch, V Gopinath, V Mahajan, MK Zilla, B Rah, SG Gandhi, A Ali, LD Kumar, A Goswami |
Cell Death and Differentiation | 2017 |
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Senescence in Health and Disease
S He, NE Sharpless |
Cell | 2017 |
|
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
M Takasugi, R Okada, A Takahashi, DV Chen, S Watanabe, E Hara |
Nature Communications | 2017 |
|
NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence
M Rojas, T Lemtalsi, H Toque, Z Xu, D Fulton, R Caldwell, R Caldwell |
Antioxidants | 2017 |
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Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?
C Abbadie, O Pluquet, A Pourtier |
Cellular and Molecular Life Sciences | 2017 |
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Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence
CD Wiley, JM Flynn, C Morrissey, R Lebofsky, J Shuga, X Dong, MA Unger, J Vijg, S Melov, J Campisi |
Aging Cell | 2017 |
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Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women
JN Justice, H Gregory, T Tchkonia, NK LeBrasseur, JL Kirkland, SB Kritchevsky, BJ Nicklas |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2017 |
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The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer
D DArcangelo, L Tinaburri, E Dellambra |
International journal of molecular sciences | 2017 |
|
A role for cellular senescence in birth timing
JM Cha, DM Aronoff |
Cell cycle (Georgetown, Tex.) | 2017 |
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The Clinical Potential of Senolytic Drugs
JL Kirkland, T Tchkonia, Y Zhu, LJ Niedernhofer, PD Robbins |
Journal of the American Geriatrics Society | 2017 |
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Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice
C Yzydorczyk, N Li, H Chehade, D Mosig, M Bidho, B Keshavjee, JB Armengaud, K Nardou, B Siddeek, M Benahmed, C Vergely, U Simeoni |
Scientific Reports | 2017 |
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Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
A Derevyanko, K Whittemore, RP Schneider, V Jiménez, F Bosch, MA Blasco |
Aging Cell | 2017 |
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A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction
PN Hsieh, G Zhou, Y Yuan, R Zhang, DA Prosdocimo, P Sangwung, AH Borton, E Boriushkin, A Hamik, H Fujioka, CE Fealy, JP Kirwan, M Peters, Y Lu, X Liao, D Ramírez-Bergeron, Z Feng, MK Jain |
Nature Communications | 2017 |
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p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli
BM Hall, V Balan, AS Gleiberman, E Strom, P Krasnov, LP Virtuoso, E Rydkina, S Vujcic, K Balan, II Gitlin, KI Leonova, CR Consiglio, SO Gollnick, OB Chernova, AV Gudkov |
Aging | 2017 |
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MiR-34a modulates ionizing radiation-induced senescence in lung cancer cells
X He, A Yang, DG McDonald, EC Riemer, KN Vanek, BA Schulte, GY Wang |
Oncotarget | 2017 |
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Decline in cellular function of aged mouse c-kit + cardiac progenitor cells: Decline in cellular function of aged CPCs
A Castaldi, RM Dodia, AM Orogo, CM Zambrano, RH Najor, ÅB Gustafsson, JH Brown, NH Purcell |
The Journal of Physiology | 2017 |
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CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease
P Stenvinkel, K Luttropp, D McGuinness, A Witasp, AR Qureshi, A Wernerson, L Nordfors, M Schalling, J Ripsweden, L Wennberg, M Söderberg, P Bárány, H Olauson, PG Shiels |
Aging | 2017 |
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Senescence and aging: Causes, consequences, and therapeutic avenues
D McHugh, J Gil |
The Journal of Cell Biology | 2017 |
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Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin
AS Wang, PF Ong, A Chojnowski, C Clavel, O Dreesen |
Scientific Reports | 2017 |
|
Multivariate Analyses of Balance Test Performance, Vestibular Thresholds, and Age
F Karmali, MC Rey, TK Clark, W Wang, DM Merfeld |
Frontiers in neurology | 2017 |
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The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy
M Schosserer, J Grillari, M Breitenbach |
Frontiers in Oncology | 2017 |
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Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile
S Buratta, L Urbanelli, K Sagini, S Giovagnoli, S Caponi, D Fioretto, N Mitro, D Caruso, C Emiliani, G Camussi |
PloS one | 2017 |
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p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
A Okuma, A Hanyu, S Watanabe, E Hara |
Nature Communications | 2017 |
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Cellular senescence in the aging and diseased kidney
FA Valentijn, LL Falke, TQ Nguyen, R Goldschmeding |
Journal of Cell Communication and Signaling | 2017 |
|
The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism
NA Almontashiri |
Journal of Taibah University Medical Sciences | 2017 |
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Senescent cells: an emerging target for diseases of ageing
BG Childs, M Gluscevic, DJ Baker, RM Laberge, D Marquess, J Dananberg, JM van Deursen |
Nature Reviews Drug Discovery | 2017 |
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Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
N Kubben, T Misteli |
Nature Reviews Molecular Cell Biology | 2017 |
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Extracellular vesicles and aging
PD Robbins |
Stem Cell Investigation | 2017 |
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Senescence-Associated MicroRNAs.
Munk R, Panda AC, Grammatikakis I, Gorospe M, Abdelmohsen K |
International review of cell and molecular biology | 2017 |
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Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs.
Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH |
Journal of Veterinary Science | 2017 |
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Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.
Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA |
Aging Cell | 2017 |
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Brain age predicts mortality.
Cole JH, Ritchie SJ, Bastin ME, Valdés Hernández MC, Muñoz Maniega S, Royle N, Corley J, Pattie A, Harris SE, Zhang Q, Wray NR, Redmond P, Marioni RE, Starr JM, Cox SR, Wardlaw JM, Sharp DJ, Deary IJ |
Molecular Psychiatry | 2017 |
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SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells.
Zhou L, Chen X, Liu T, Zhu C, Si M, Jargstorf J, Li M, Pan G, Gong Y, Luo ZP, Yang H, Pei M, He F |
Journal of Tissue Engineering and Regenerative Medicine | 2017 |
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Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse.
Ito T, Yamamoto N, Nakajima S, Schaffer SW |
Advances in experimental medicine and biology | 2017 |
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COUP-TFII regulates satellite cell function and muscular dystrophy
Xin Xie, Sophia Y. Tsai, Ming-Jer Tsai |
Journal of Clinical Investigation | 2016 |
|
Elimination of p19ARF-expressing cells enhances pulmonary function in mice
Michihiro Hashimoto, Azusa Asai, Hiroyuki Kawagishi, Ryuta Mikawa, Yuji Iwashita, Kazuki Kanayama, Kazushi Sugimoto, Tadashi Sato, Mitsuo Maruyama, Masataka Sugimoto |
JCI Insight | 2016 |
|
Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
S Dhawan, E Dirice, RN Kulkarni, A Bhushan |
Diabetes | 2016 |
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Aging and Autophagy in the Heart
A Shirakabe, Y Ikeda, S Sciarretta, DK Zablocki, J Sadoshima |
Circulation research | 2016 |
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Islet biology, the CDKN2A/B locus and type 2 diabetes risk
Y Kong, RB Sharma, BU Nwosu, LC Alonso |
Diabetologia | 2016 |
|
Critical Roles of Reactive Oxygen Species in Age-Related Impairment in Ischemia-Induced Neovascularization by Regulating Stem and Progenitor Cell Function
YT Lam |
Oxidative medicine and cellular longevity | 2016 |
|
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
EP Crowe, F Tuzer, BD Gregory, G Donahue, SJ Gosai, J Cohen, YY Leung, E Yetkin, R Nativio, LS Wang, C Sell, NM Bonini, SL Berger, FB Johnson, C Torres |
Frontiers in aging neuroscience | 2016 |
|
Energetic interventions for healthspan and resiliency with aging
DM Huffman, MJ Schafer, NK LeBrasseur |
Experimental Gerontology | 2016 |
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Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts
Y Ding, J Chen, IS Okon, MH Zou, P Song |
The International Journal of Biochemistry & Cell Biology | 2016 |
|
Cellular senescence: Implications for metabolic disease
MJ Schafer, JD Miller, NK LeBrasseur |
Molecular and Cellular Endocrinology | 2016 |
|
Metallothionein prevents age-associated cardiomyopathy via inhibiting NF-κB pathway activation and associated nitrative damage to 2-OGD
W Cong, C Niu, L Lv, M Ni, D Ruan, L Chi, Y Wang, Q Yu, K Zhan, Y Xuan, Y Wang, Y Tan, T Wei, L Cai, L Jin |
Antioxidants & Redox Signaling | 2016 |
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Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging
WA Wood, J Krishnamurthy, N Mitin, C Torrice, JS Parker, AC Snavely, TC Shea, JS Serody, NE Sharpless |
EBioMedicine | 2016 |
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DNA Damage: A Main Determinant of Vascular Aging
P Bautista-Niño, E Portilla-Fernandez, D Vaughan, A Danser, A Roks |
International journal of molecular sciences | 2016 |
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Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells
HJ Jin, HJ Lee, J Heo, J Lim, M Kim, MK Kim, HY Nam, GH Hong, YS Cho, SJ Choi, IG Kim, DM Shin, SW Kim |
Antioxidants & Redox Signaling | 2016 |
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Disorganization of the splenic microanatomy in ageing mice
D Aw, L Hilliard, Y Nishikawa, ET Cadman, RA Lawrence, DB Palmer |
Immunology | 2016 |
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SNEV P rp19/ PSO 4 deficiency increases PUVA-induced senescence in mouse skin
R Monteforte, GF Beilhack, R Grausenburger, B Mayerhofer, R Bittner, R Grillari-Voglauer, M Sibilia, H Dellago, E Tschachler, F Gruber, J Grillari |
Experimental Dermatology | 2016 |
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Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling
N Zhang, Z Li, W Mu, L Li, Y Liang, M Lu, Z Wang, Y Qiu, Z Wang |
Cell cycle (Georgetown, Tex.) | 2016 |
|
Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice
KA Kim, JJ Jeong, SY Yoo, DH Kim |
BMC Microbiology | 2016 |
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p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes
R Menon, J Papaconstantinou |
Expert Opinion on Therapeutic Targets | 2016 |
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Cellular senescence impact on immune cell fate and function
R Vicente, AL Mausset-Bonnefont, C Jorgensen, P Louis-Plence, JM Brondello |
Aging Cell | 2016 |
|
Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults
A Pustavoitau, V Barodka, NE Sharpless, C Torrice, D Nyhan, DE Berkowitz, AS Shah, KJ Roche, JD Walston |
Experimental Gerontology | 2016 |
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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle
DW Frederick, E Loro, L Liu, A Davila, K Chellappa, IM Silverman, WJ Quinn, SJ Gosai, ED Tichy, JG Davis, F Mourkioti, BD Gregory, RW Dellinger, P Redpath, ME Migaud, E Nakamaru-Ogiso, JD Rabinowitz, TS Khurana, JA Baur |
Cell Metabolism | 2016 |
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Validation and comparison of instruments to identify frail patientes in primary care settings: Study protocol
I Vergara, F Rivas-Ruiz, K Vrotsou, E Contreras-Fernández, T Téllez-Santana, M Machón, AI Ruiz, YM Berenguer, A Bueno, J Núñez, MC Figueredo, A Montiel-Luque, MA Val, R Quirós-López, E Carrasco, G Abellan |
BMC health services research | 2016 |
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Chemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin Fluctuation
YJ Chao, JF Chan, YH Hsu, GL Lluch |
PloS one | 2016 |
|
Telomeres in aging and disease: lessons from zebrafish
MC Carneiro, IP de Castro, MG Ferreira |
Disease models & mechanisms | 2016 |
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Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
BM Hall, V Balan, AS Gleiberman, E Strom, P Krasnov, LP Virtuoso, E Rydkina, S Vujcic, K Balan, I Gitlin, K Leonova, A Polinsky, OB Chernova, AV Gudkov |
Aging | 2016 |
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Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans
FG Mann, EL van Nostrand, AE Friedland, X Liu, SK Kim, CT Murphy |
PLoS genetics | 2016 |
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Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife
CE Sørensen, K Tritsaris, J Reibel, M Lauritzen, EL Mortensen, M Osler, AM Pedersen, GD Pasquale |
PloS one | 2016 |
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Fuchs endothelial corneal dystrophy: current perspectives
A Jun, G Vedana, G Villarreal |
Clinical ophthalmology (Auckland, N.Z.) | 2016 |
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p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
A Helman, A Klochendler, N Azazmeh, Y Gabai, E Horwitz, S Anzi, A Swisa, R Condiotti, RZ Granit, Y Nevo, Y Fixler, D Shreibman, A Zamir, S Tornovsky-Babeay, C Dai, B Glaser, AC Powers, AM Shapiro, MA Magnuson, Y Dor, I Ben-Porath |
Nature Medicine | 2016 |
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Biomarkers of skin aging
T Kanaki, E Makrantonaki, CC Zouboulis |
Reviews in Endocrine and Metabolic Disorders | 2016 |
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Cellular senescence in renal ageing and disease
I Sturmlechner, M Durik, CJ Sieben, DJ Baker, JM van Deursen |
Nature Reviews Nephrology | 2016 |
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Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
M Bassiouni, AD Santos, HX Avci, H Löwenheim, M Müller, BB Riley |
PloS one | 2016 |
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Role of lncRNAs in Cellular Aging
U Degirmenci, S Lei |
Frontiers in Endocrinology | 2016 |
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Identification of Senescent Cells in the Bone Microenvironment: SENESCENCE IN THE BONE MICROENVIRONMENT
JN Farr, DG Fraser, H Wang, K Jaehn, MB Ogrodnik, MM Weivoda, MT Drake, T Tchkonia, NK LeBrasseur, JL Kirkland, LF Bonewald, RJ Pignolo, DG Monroe, S Khosla |
Journal of Bone and Mineral Research | 2016 |
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Molecular pathology endpoints useful for aging studies
LJ Niedernhofer, JL Kirkland, W Ladiges |
Ageing Research Reviews | 2016 |
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The role of hydrogen sulfide in aging and age-related pathologies
B Perridon, H Leuvenink, JL Hillebrands, H Goor, E Bos |
Aging | 2016 |
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p16INK4a suppresses BRCA1-deficient mammary tumorigenesis
A Scott, F Bai, HL Chan, S Liu, J Ma, JM Slingerland, DJ Robbins, AJ Capobianco, XH Pei |
Oncotarget | 2016 |
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Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice
D Drummond, M Baravalle-Einaudi, G Lezmi, S Vibhushan, ML Franco-Montoya, A Hadchouel, J Boczkowski, C Delacourt |
Environmental Health Perspectives | 2016 |
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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
M Demaria, MN O'Leary, J Chang, L Shao, S Liu, F Alimirah, K Koenig, C Le, N Mitin, AM Deal, S Alston, EC Academia, S Kilmarx, A Valdovinos, B Wang, A Bruin, BK Kennedy, S Melov, D Zhou, NE Sharpless, H Muss, J Campisi |
Cancer Discovery | 2016 |
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Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1
CE Burd, MS Gill, LJ Niedernhofer, PD Robbins, SN Austad, N Barzilai, JL Kirkland |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
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SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair
BN Vazquez, JK Thackray, NG Simonet, N KaneGoldsmith, P MartinezRedondo, T Nguyen, S Bunting, A Vaquero, JA Tischfield, L Serrano |
The EMBO Journal | 2016 |
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Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.
Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G |
Aging | 2016 |
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Pervasive Effects of Aging on Gene Expression in Wild Wolves
Charruau P, Johnston RA, Stahler DR, Lea A, Snyder-Mackler N, Smith DW, vonHoldt BM, Cole SW, Tung J, Wayne RK |
Molecular Biology and Evolution | 2016 |
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Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
MO Grootaert, PA da Martins, N Bitsch, I Pintelon, GR de Meyer, W Martinet, DM Schrijvers |
Autophagy | 2015 |
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Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization
H Toba, LE de Brás, CF Baicu, MR Zile, ML Lindsey, AD Bradshaw |
American journal of physiology. Cell physiology | 2015 |
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Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice
G Xu, H Wu, J Zhang, D Li, Y Wang, Y Wang, H Zhang, L Lu, C Li, S Huang, Y Xing, D Zhou, A Meng |
Free radical biology & medicine | 2015 |
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Therapeutic targeting of replicative immortality
P Yaswen, KL MacKenzie, WN Keith, P Hentosh, F Rodier, J Zhu, GL Firestone, A Matheu, A Carnero, A Bilsland, T Sundin, K Honoki, H Fujii, AG Georgakilas, A Amedei, A Amin, B Helferich, CS Boosani, G Guha, MR Ciriolo, S Chen, SI Mohammed, AS Azmi, D Bhakta, D Halicka, E Niccolai, K Aquilano, SS Ashraf, S Nowsheen, X Yang |
Seminars in Cancer Biology | 2015 |
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Cellular senescence in aging and age-related disease: from mechanisms to therapy
BG Childs, M Durik, DJ Baker, JM van Deursen |
Nature Medicine | 2015 |
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Bone Marrow Mesenchymal Stem Cell Transplantation Retards the Natural Senescence of Rat Hearts
M Zhang, D Liu, S Li, L Chang, Y Zhang, R Liu, F Sun, W Duan, W Du, Y Wu, T Zhao, C Xu, Y Lu |
Stem Cells Translational Medicine | 2015 |
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Telomerase deficiency delays renal recovery in mice after ischemia–reperfusion injury by impairing autophagy
H Cheng, X Fan, WE Lawson, P Paueksakon, RC Harris |
Kidney International | 2015 |
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Regulation of the p19 Arf /p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice
R Soriano-Cantón, A Perez-Villalba, JM Morante-Redolat, MÁ Marqués-Torrejón, M Pallás, F Pérez-Sánchez, I Fariñas |
Aging Cell | 2015 |
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The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer’s Disease?
G Sarlak, B Vincent |
Molecular Neurobiology | 2015 |
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A systems view of epigenetic networks regulating pancreas development and β-cell function: Epigenetic networks in pancreas development and function
R Xie, AC Carrano, M Sander |
Wiley Interdisciplinary Reviews Systems Biology and Medicine | 2015 |
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Cellular senescence: a hitchhiker’s guide
A Aravinthan |
Human Cell | 2015 |
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Aging and radiation: bad companions
L Hernández, M Terradas, J Camps, M Martín, L Tusell, A Genescà |
Aging Cell | 2015 |
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The Intricate Interplay between Mechanisms Underlying Aging and Cancer
A Piano, VI Titorenko |
Aging and disease | 2015 |
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Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors
A Papoudou-Bai, A Barbouti, V Galani, K Stefanaki, D Rontogianni, P Kanavaros |
Clinical and Experimental Medicine | 2015 |
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Dysregulation of the Bmi-1/p16 Ink4a pathway provokes an aging-associated decline of submandibular gland function
K Yamakoshi, S Katano, M Iida, H Kimura, A Okuma, M Ikemoto-Uezumi, N Ohtani, E Hara, M Maruyama |
Aging Cell | 2015 |
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Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin
M Demaria, PY Desprez, J Campisi, MC Velarde |
Journal of Investigative Dermatology | 2015 |
|
Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
RR White, B Milholland, A Bruin, S Curran, RM Laberge, H Steeg, J Campisi, AY Maslov, J Vijg |
Nature Communications | 2015 |
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Overexpression of the Novel Senescence Marker β-Galactosidase (GLB1) in Prostate Cancer Predicts Reduced PSA Recurrence
J Wagner, N Damaschke, B Yang, M Truong, C Guenther, J McCormick, W Huang, D Jarrard, N Kyprianou |
PloS one | 2015 |
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Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
S Sato, Y Kawamata, A Takahashi, Y Imai, A Hanyu, A Okuma, M Takasugi, K Yamakoshi, H Sorimachi, H Kanda, Y Ishikawa, S Sone, Y Nishioka, N Ohtani, E Hara |
Nature Communications | 2015 |
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Mutant lamin A links prophase to a p53 independent senescence program
O Moiseeva, F Lessard, M Acevedo-Aquino, M Vernier, YS Tsantrizos, G Ferbeyre |
Cell cycle (Georgetown, Tex.) | 2015 |
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Melatonin reverses H 2 O 2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway
L Zhou, X Chen, T Liu, Y Gong, S Chen, G Pan, W Cui, ZP Luo, M Pei, H Yang, F He |
Journal of Pineal Research | 2015 |
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Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model
C Jiang, X Hu, L Wang, H Cheng, Y Lin, Y Pang, W Yuan, T Cheng, J Wang |
Journal of Translational Medicine | 2015 |
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Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation
AS Carvajal, T McKenna, EW Arzt, M Eriksson, RL Eckert |
PloS one | 2015 |
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Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr |
Nature Reviews Cancer | 2015 |
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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
A Gutierrez-Fernandez, C Soria-Valles, FG Osorio, J Gutierrez-Abril, C Garabaya, A Aguirre, A Fueyo, MS Fernandez-Garcia, XS Puente, C Lopez-Otin |
The EMBO Journal | 2015 |
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P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
D Skowronska-Krawczyk, L Zhao, J Zhu, RN Weinreb, G Cao, J Luo, K Flagg, S Patel, C Wen, M Krupa, H Luo, H Ouyang, D Lin, W Wang, G Li, Y Xu, O Li, C Chung, E Yeh, M Jafari, M Ai, Z Zhong, W Shi, L Zheng, M Krawczyk, D Chen, C Shi, C Zin, J Zhu, PL Mellon, W Gao, R Abagyan, L Zhang, X Sun, S Zhong, Y Zhuo, MG Rosenfeld, Y Liu, K Zhang |
Molecular Cell | 2015 |
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Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
JE Carroll, SW Cole, TE Seeman, EC Breen, T Witarama, JM Arevalo, J Ma, MR Irwin |
Brain, Behavior, and Immunity | 2015 |
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Senescence and cancer: An evolving inflammatory paradox
MK Ruhland, LM Coussens, SA Stewart |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2015 |
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Senescence from G2 arrest, revisited
V Gire, V Dulić |
Cell cycle (Georgetown, Tex.) | 2015 |
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The role of sirtuins in cardiac disease
S Matsushima, J Sadoshima |
American journal of physiology. Heart and circulatory physiology | 2015 |
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Comprehensive transcriptional landscape of aging mouse liver
RR White, B Milholland, SL MacRae, M Lin, D Zheng, J Vijg |
BMC Genomics | 2015 |
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Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility
RS Sarker, G John-Schuster, A Bohla, K Mutze, G Burgstaller, MT Bedford, M Königshoff, O Eickelberg, AÖ Yildirim |
American journal of respiratory cell and molecular biology | 2015 |
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Effects of rhein lysinate on D-galactose-induced aging mice
YZ Zhen, YJ Lin, KJ Li, GL Zhang, YF Zhao, MM Wang, JB Wei, J Wei, G Hu |
Experimental and therapeutic medicine | 2015 |
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Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans
SM Zimmerman, IV Hinkson, JE Elias, SK Kim, GP Copenhaver |
PLoS genetics | 2015 |
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Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression
N Troyano-Suárez, M Nogal-Avila, I Mora, P Sosa, S López-Ongil, D Rodriguez-Puyol, G Olmos, MP Ruíz-Torres |
Oxidative medicine and cellular longevity | 2015 |
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Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF
P Koudelkova, G Weber, W Mikulits, D Calvisi |
PloS one | 2015 |
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Senescence-associated Long Non-coding RNA ( SALNR ) Delays Oncogene-induced Senescence through NF90 Regulation
CL Wu, Y Wang, B Jin, H Chen, BS Xie, ZB Mao |
The Journal of biological chemistry | 2015 |
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Nestlé Nutrition Institute Workshop Series: 83rd Nestlé Nutrition Institute Workshop, Barcelona, March 2014
NK LeBrasseur, T Tchkonia, JL Kirkland |
Nestle Nutrition Institute workshop series | 2015 |
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DNA damage response at telomeres contributes to lung ageing and chronic obstructive pulmonary disease
J Birch, RK Anderson, C Correia-Melo, D Jurk, G Hewitt, FM Marques, NJ Green, E Moisey, MA Birrell, MG Belvisi, F Black, JJ Taylor, AJ Fisher, AD Soyza, JF Passos |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
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P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age
ME Waaijer, DA Gunn, PD Adams, JS Pawlikowski, CE Griffiths, D Heemst, PE Slagboom, RG Westendorp, AB Maier |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells
Papaconstantinou J, Wang CZ, Zhang M, Yang S, Deford J, Bulavin DV, Ansari NH |
Aging | 2015 |
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MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways
Z Hu, JD Klein, WE Mitch, L Zhang, I Martinez, XH Wang |
Aging | 2014 |
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Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice
M Hosseini, W Mahfouf, M Serrano-Sanchez, H Raad, G Harfouche, M Bonneu, S Claverol, F Mazurier, R Rossignol, A Taieb, HR Rezvani |
Journal of Investigative Dermatology | 2014 |
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Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
J Zhang, E Xu, C Ren, W Yan, M Zhang, M Chen, RD Cardiff, DM Imai, E Wisner, X Chen |
Proceedings of the National Academy of Sciences | 2014 |
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Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner
L Shao, W Feng, H Li, D Gardner, Y Luo, Y Wang, L Liu, A Meng, NE Sharpless, D Zhou |
Blood | 2014 |
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Cathepsin K knockout alleviates aging-induced cardiac dysfunction
Y Hua, TJ Robinson, Y Cao, GP Shi, J Ren, S Nair |
Aging Cell | 2014 |
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Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease
M Sauler, L Leng, M Trentalange, M Haslip, P Shan, M Piecychna, Y Zhang, N Andrews, P Mannam, H Allore, T Fried, R Bucala, PJ Lee |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
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The regulation of pre- and post-maturational plasticity of mammalian islet cell mass
T Mezza, RN Kulkarni |
Diabetologia | 2014 |
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Cellular mechanisms of somatic stem cell aging
Y Jung, AS Brack |
Current topics in developmental biology | 2014 |
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Smurf2 regulates hematopoietic stem cell self-renewal and aging
C Ramkumar, Y Kong, SE Trabucco, RM Gerstein, H Zhang |
Aging Cell | 2014 |
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The role of senescent cells in ageing
JM van Deursen |
Nature | 2014 |
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Impact of genomic damage and ageing on stem cell function
A Behrens, JM van Deursen, KL Rudolph, B Schumacher |
Nature Cell Biology | 2014 |
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Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
J Zhang, L Wan, X Dai, Y Sun, W Wei |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
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Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence: Sa-β-Gal Activity in Early Mouse Embryos
T Huang, JA Rivera-Pérez |
genesis | 2014 |
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Developmental stage-specific transformation of neural progenitors
DM Muñoz, C Hawkins |
Cell cycle (Georgetown, Tex.) | 2014 |
|
Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
HK Sanoff, AM Deal, J Krishnamurthy, C Torrice, P Dillon, J Sorrentino, JG Ibrahim, TA Jolly, G Williams, LA Carey, A Drobish, BB Gordon, S Alston, A Hurria, K Kleinhans, KL Rudolph, NE Sharpless, HB Muss |
JNCI Journal of the National Cancer Institute | 2014 |
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Radiation-Induced Bystander Response: Mechanism and Clinical Implications
K Suzuki, S Yamashita |
Advances in Skin & Wound Care | 2014 |
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Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and time
P Sosińska, J Mikuła-Pietrasik, M Ryżek, E Naumowicz, K Książek |
Biogerontology | 2014 |
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Cellular senescence: from physiology to pathology
D Muñoz-Espín, M Serrano |
Nature Reviews Molecular Cell Biology | 2014 |
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Defining the toxicology of aging
JA Sorrentino, HK Sanoff, NE Sharpless |
Trends in Molecular Medicine | 2014 |
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Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion?
HH Chen, NA Almontashiri, D Antoine, AF Stewart |
Current Cardiology Reports | 2014 |
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Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
C Correia-Melo, G Hewitt, JF Passos |
Longevity & Healthspan | 2014 |
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The effects of aging on the expression of Wnt pathway genes in mouse tissues
JW Hofmann, T McBryan, PD Adams, JM Sedivy |
AGE | 2014 |
|
Cellular senescence and its effector programs
R Salama, M Sadaie, M Hoare, M Narita |
Genes & development | 2014 |
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Age-Related Impairment of Pancreatic Beta-Cell Function: Pathophysiological and Cellular Mechanisms
VD Tata |
Frontiers in Endocrinology | 2014 |
|
The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
EY Min, IH Kim, J Lee, EY Kim, YH Choi, TJ Nam |
International journal of oncology | 2014 |
|
Epigenetics of hematopoietic stem cell aging and disease
M Oshima, A Iwama |
International Journal of Hematology | 2014 |
|
Natural Compounds and Aging: Between Autophagy and Inflammasome
SY Chuang, CH Lin, JY Fang |
BioMed Research International | 2014 |
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INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform
X Tian, J Azpurua, Z Ke, A Augereau, ZD Zhang, J Vijg, VN Gladyshev, V Gorbunova, A Seluanov |
Proceedings of the National Academy of Sciences | 2014 |
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Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy
M Matthaei, AY Zhu, L Kallay, CG Eberhart, C Cursiefen, AS Jun |
Experimental Eye Research | 2014 |
|
Comprehensive geriatric assessment in the older cancer patient: coming of age in clinical cancer care
C Owusu, NA Berger |
Clinical Practice | 2014 |
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Clinical strategies and animal models for developing senolytic agents
JL Kirkland, T Tchkonia |
Experimental Gerontology | 2014 |
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Stn1 is critical for telomere maintenance and long-term viability of somatic human cells
V Boccardi, N Razdan, J Kaplunov, JJ Mundra, M Kimura, A Aviv, U Herbig |
Aging Cell | 2014 |
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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
M Demaria, N Ohtani, SA Youssef, F Rodier, W Toussaint, JR Mitchell, RM Laberge, J Vijg, H Van Steeg, ME Dollé, JH Hoeijmakers, A de Bruin, E Hara, J Campisi |
Developmental Cell | 2014 |
|
Geroconversion of aged muscle stem cells under regenerative pressure
P Sousa-Victor, E Perdiguero, P Muñoz-Cánoves |
Cell cycle (Georgetown, Tex.) | 2014 |
|
Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16 Ink4a
A Boquoi, S Arora, T Chen, S Litwin, J Koh, GH Enders |
Aging Cell | 2014 |
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Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice
T Ito, N Yoshikawa, T Inui, N Miyazaki, SW Schaffer, J Azuma, AS Lewin |
PloS one | 2014 |
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Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy
K Grenier, M Kontogiannea, EA Fon |
The Journal of biological chemistry | 2014 |
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Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation
M Wahlestedt, CJ Pronk, D Bryder |
Stem Cells Translational Medicine | 2014 |
|
Interdisciplinary Topics in Gerontology: Facts and Theories
J Campisi, L Robert |
Interdisciplinary topics in gerontology | 2014 |
|
Incorporating Biomarkers Into Cancer and Aging Research
JM Hubbard, HJ Cohen, HB Muss |
Journal of Clinical Oncology | 2014 |
|
Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro : Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein
JH Jang, S Bruse, S Huneidi, RM Schrader, MM Monick, Y Lin, AB Carter, AJ Klingelhutz, T Nyunoya |
Environmental Health Perspectives | 2014 |
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Early life obesity and chronic kidney disease in later life.
Yim HE, Yoo KH |
Pediatric nephrology (Berlin, Germany) | 2014 |
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Polycomb and Trithorax regulation of Ink4a to regenerate beta cells
Josie Zhou, Sangeeta Dhawan, Hualin Fu, Emily Snyder, Rita Bottino, Sharmistha Kundu, Seung Kim, Anil Bhushan |
Journal of Clinical Investigation | 2013 |
|
Hypochlorite Inhibits IKK, Attenuates Radiation Dermatitis, and Rejuvenates Aged Skin
Thomas Leung, Lillian Zhang, Jing Wang, Shoucheng Ning, Susan Knox, Seung Kim |
Journal of Clinical Investigation | 2013 |
|
p16INK4aprotects tissues from dysfunctional telomere induced DNA damage responses
Yang Wang, Norman Sharpless, Sandy Chang |
Journal of Clinical Investigation | 2013 |
|
Gerontogen Testing in p16LUC-Reporter Mice
Jessica Sorrentino, Janakiraman Krishnamurthy, Stephen Tilley, James Alb, Christin Burd, Norman Sharpless |
Journal of Clinical Investigation | 2013 |
|
Causes, consequences, and reversal of immune system aging
Encarnacion Montecino, Beata Berent, Kenneth Dorshkind |
Journal of Clinical Investigation | 2013 |
|
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tamara Tchkonia, Yi Zhu, Jan Van Deursen, Judith Campisi, James Kirkland |
Journal of Clinical Investigation | 2013 |
|
The role of aging upon β-cell turnover
Jake Kushner |
Journal of Clinical Investigation | 2013 |
|
PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16(ink4a.)
N Zeng, KT Yang, JA Bayan, L He, R Aggarwal, JW Stiles, X Hou, V Medina, D Abad, BM Palian, I Al-Abdullah, F Kandeel, DL Johnson, BL Stiles |
Aging Cell | 2013 |
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Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis
T Uehara, GR Ainslie, K Kutanzi, IP Pogribny, L Muskhelishvili, T Izawa, J Yamate, O Kosyk, S Shymonyak, BU Bradford, GA Boorman, R Bataller, I Rusyn |
Toxicological Sciences | 2013 |
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Aging, Cellular Senescence, and Cancer
J Campisi |
Annual Review of Physiology | 2013 |
|
Mitochondrial DNA damage induces apoptosis in senescent cells
RM Laberge, D Adler, M DeMaria, N Mechtouf, R Teachenor, GB Cardin, PY Desprez, J Campisi, F Rodier |
Cell Death and Disease | 2013 |
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The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
K Evangelou, J Bartkova, A Kotsinas, IS Pateras, M Liontos, G Velimezi, M Kosar, T Liloglou, IP Trougakos, L Dyrskjot, CL Andersen, M Papaioannou, Y Drosos, G Papafotiou, Z Hodny, B Sosa-Pineda, XR Wu, A Klinakis, T Ørntoft, J Lukas, J Bartek, VG Gorgoulis |
Cell Death and Differentiation | 2013 |
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Differential transformation capacity of neuro-glial progenitors during development
DM Munoz, S Singh, T Tung, S Agnihotri, A Nagy, A Guha, G Zadeh, C Hawkins |
Proceedings of the National Academy of Sciences | 2013 |
|
The in situ local immune response, tumour senescence and proliferation in colorectal cancer
CS Roxburgh, CH Richards, AI MacDonald, AG Powell, LM McGlynn, DC McMillan, PG Horgan, J Edwards, PG Shiels |
British Journal of Cancer | 2013 |
|
Mechanistic links between aging and lung fibrosis
VJ Thannickal |
Biogerontology | 2013 |
|
Increased expression of senescence markers in cystic fibrosis airways
BM Fischer, JK Wong, S Degan, AB Kummarapurugu, S Zheng, P Haridass, JA Voynow |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
|
Is cancer incidence decreased in the frail elderly? Evidence from a prospective cohort study
B Kanapuru, EM Simonsick, WB Ershler |
Journal of Geriatric Oncology | 2013 |
|
Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression
JJ Wu, J Liu, EB Chen, JJ Wang, L Cao, N Narayan, MM Fergusson, II Rovira, M Allen, DA Springer, CU Lago, S Zhang, W DuBois, T Ward, R deCabo, O Gavrilova, B Mock, T Finkel |
Cell Reports | 2013 |
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Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
C Giachino, L Orlando, V Turinetto |
International journal of molecular sciences | 2013 |
|
p16INK4A Influences the Aging Phenotype in the Living Skin Equivalent
J Adamus, S Aho, H Meldrum, C Bosko, JM Lee |
Journal of Investigative Dermatology | 2013 |
|
ANRIL: Molecular Mechanisms and Implications in Human Health
A Congrains, K Kamide, M Ohishi, H Rakugi |
International journal of molecular sciences | 2013 |
|
Is HIV a Model of Accelerated or Accentuated Aging?
S Pathai, H Bajillan, AL Landay, KP High |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2013 |
|
ARF induction in response to DNA strand breaks is regulated by PARP1
G Orlando, SV Khoronenkova, II Dianova, JL Parsons, GL Dianov |
Nucleic Acids Research | 2013 |
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Cellular senescence mediated by p16INK4A-coupled miRNA pathways
MG Overhoff, JC Garbe, J Koh, MR Stampfer, DH Beach, CL Bishop |
Nucleic Acids Research | 2013 |
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HuR maintains a replicative life span by repressing the ARF tumor suppressor
H Kawagishi, M Hashimoto, H Nakamura, T Tsugawa, A Watanabe, DL Kontoyiannis, M Sugimoto |
Molecular and cellular biology | 2013 |
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Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells
M Matsuyama, H Tanaka, A Inoko, H Goto, S Yonemura, K Kobori, Y Hayashi, E Kondo, S Itohara, I Izawa, M Inagaki |
The Journal of biological chemistry | 2013 |
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Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys
J Cui, S Shi, X Sun, G Cai, S Cui, Q Hong, X Chen, XY Bai |
PloS one | 2013 |
|
PML, SUMOylation, and Senescence
L Ivanschitz, HD Thé, ML Bras |
Frontiers in Oncology | 2013 |
|
Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
G Despars, CL Carbonneau, P Bardeau, DL Coutu, CM Beauséjour |
PloS one | 2013 |
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Ocular parameters of biological ageing in HIV-infected individuals in South Africa: Relationship with chronological age and systemic biomarkers of ageing
S Pathai, PG Shiels, HA Weiss, CE Gilbert, T Peto, LG Bekker, R Wood, TY Wong, SD Lawn |
Mechanisms of Ageing and Development | 2013 |
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Assessment of candidate ocular biomarkers of ageing in a South African adult population: Relationship with chronological age and systemic biomarkers
S Pathai, CE Gilbert, SD Lawn, HA Weiss, T Peto, C Cook, TY Wong, PG Shiels |
Mechanisms of Ageing and Development | 2013 |
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The Hallmarks of Aging
C López-Otín, MA Blasco, L Partridge, M Serrano, G Kroemer |
Cell | 2013 |
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Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
CE Burd, JA Sorrentino, KS Clark, DB Darr, J Krishnamurthy, AM Deal, N Bardeesy, DH Castrillon, DH Beach, NE Sharpless |
2013 | |
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Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review
L Sensebé, M Gadelorge, S Fleury-Cappellesso |
2013 | |
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Senescence at a glance
JS Pawlikowski, PD Adams, DM Nelson |
2013 | |
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Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study
S Marcoux, ON Le, C Langlois-Pelletier, C Laverdière, A Hatami, P Robaey, CM Beauséjour |
2013 | |
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Clinical significance of cell cycle inhibitors in hepatocellular carcinoma
Y Matsuda, T Wakai, M Kubota, M Takamura, S Yamagiwa, Y Aoyagi, M Osawa, S Fujimaki, A Sanpei, T Genda, T Ichida |
Medical Molecular Morphology | 2013 |
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Dmp1α Inhibits HER2/neu-Induced Mammary Tumorigenesis
EA Fry, P Taneja, D Maglic, S Zhu, G Sui, K Inoue, Q Li |
PloS one | 2013 |
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Aging increases CCN1 expression leading to muscle senescence
J Du, JD Klein, F Hassounah, J Zhang, C Zhang, XH Wang |
American journal of physiology. Cell physiology | 2013 |
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The Molecular Balancing Act of p16INK4a in Cancer and Aging
KM LaPak, CE Burd |
Molecular cancer research : MCR | 2013 |
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Usp16 contributes to somatic stem-cell defects in Down’s syndrome
M Adorno, S Sikandar, SS Mitra, A Kuo, BN di Robilant, V Haro-Acosta, Y Ouadah, M Quarta, J Rodriguez, D Qian, VM Reddy, S Cheshier, CC Garner, MF Clarke |
Nature | 2013 |
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Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease
M Kawai, Y Ogawa, S Shimmura, S Ohta, T Suzuki, N Kawamura, M Kuwana, Y Kawakami, K Tsubota |
Scientific Reports | 2013 |
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Effects of Aging on Kidney Graft Function, Oxidative Stress and Gene Expression after Kidney Transplantation
R Ding, X Chen, D Wu, R Wei, Q Hong, S Shi, Z Yin, L Ma, Y Xie, Q Sun |
PloS one | 2013 |
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Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
H Luo, C Yount, H Lang, A Yang, EC Riemer, K Lyons, KN Vanek, GA Silvestri, BA Schulte, GY Wang |
Lung Cancer | 2013 |
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p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
DJ Baker, RL Weaver, JM van Deursen |
Cell Reports | 2013 |
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Methods in Molecular Biology
K Itahana, Y Itahana, GP Dimri |
Methods in molecular biology (Clifton, N.J.) | 2013 |
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Mechanisms that Regulate Stem Cell Aging and Life Span
RA Signer, SJ Morrison |
Cell Stem Cell | 2013 |
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Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
N Ohtani, E Hara |
Cancer Science | 2013 |
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Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice
H Zhang, Z Zhai, Y Wang, J Zhang, H Wu, Y Wang, C Li, D Li, L Lu, X Wang, J Chang, Q Hou, Z Ju, D Zhou, A Meng |
Free radical biology & medicine | 2013 |
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A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation
Lee SJ, Lee SH, Yoon MH, Park BJ |
Neoplasia (New York, N.Y.) | 2013 |
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Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM, Kreiling JA |
Aging | 2013 |
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Chemical Methods to Induce Beta-Cell Proliferation
A Vetere, BK Wagner |
International Journal of Endocrinology | 2012 |
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Bone Marrow p16INK4a-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development
K Wouters, C Cudejko, MJ Gijbels, L Fuentes, K Bantubungi, J Vanhoutte, R Dièvart, C Paquet, E Bouchaert, SA Hannou, F Gizard, A Tailleux, MP de Winther, B Staels, R Paumelle |
PloS one | 2012 |
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Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging
Z Gong, RH Muzumdar |
International Journal of Endocrinology | 2012 |
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Epigenetic regulation of pancreas development and function
D Avrahami, KH Kaestner |
Seminars in Cell & Developmental Biology | 2012 |
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An acute negative bystander effect of -irradiated recipients on transplanted hematopoietic stem cells
H Shen, H Yu, PH Liang, H Cheng, R XuFeng, Y Yuan, P Zhang, CA Smith, T Cheng |
Blood | 2012 |
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Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a
B Berent-Maoz, E Montecino-Rodriguez, RA Signer, K Dorshkind |
Blood | 2012 |
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Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
A Salminen, JM Hyttinen, A Kauppinen, K Kaarniranta |
International Journal of Cell Biology | 2012 |
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Diet and Aging
S Ribarič |
Oxidative medicine and cellular longevity | 2012 |
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Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells
SA Larsen, M Kassem, SI Rattan |
Chemistry Central Journal | 2012 |
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Alternative Strategy for Alzheimer's Disease: Stress Response Triggers
JS Sonneborn |
International Journal of Alzheimer's Disease | 2012 |
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Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells
MY Yang, PM Lin, YC Liu, HH Hsiao, WC Yang, JF Hsu, CM Hsu, SF Lin |
PloS one | 2012 |
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Bmi1 Is Down-Regulated in the Aging Brain and Displays Antioxidant and Protective Activities in Neurons
M Abdouh, W Chatoo, JE Hajjar, J David, J Ferreira, G Bernier |
PloS one | 2012 |
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Premature expression of a muscle fibrosis axis in chronic HIV infection
RL Kusko, C Banerjee, KK Long, A Darcy, J Otis, P Sebastiani, S Melov, M Tarnopolsky, S Bhasin, M Montano |
Skeletal Muscle | 2012 |
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Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
RM Naylor, DJ Baker, JM van Deursen |
Clinical Pharmacology & Therapeutics | 2012 |
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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
DJ Baker, MM Dawlaty, T Wijshake, KB Jeganathan, L Malureanu, JH van Ree, R Crespo-Diaz, S Reyes, L Seaburg, V Shapiro, A Behfar, A Terzic, B de Sluis, JM van Deursen |
Nature Cell Biology | 2012 |
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Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia
EJ Volanakis, MR Boothby, CJ Sherr |
Experimental Hematology | 2012 |
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Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?
ME Levine |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2012 |
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Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
TA Rando, HY Chang |
Cell | 2012 |
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The great unravelling: chromatin as a modulator of the aging process
RJ O'Sullivan, J Karlseder |
Trends in Biochemical Sciences | 2012 |
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Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD
H Yao, I Rahman |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
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mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription
AR Pont, N Sadri, SJ Hsiao, S Smith, RJ Schneider |
2012 | |
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The role of manganese superoxide dismutase in skin aging
N Treiber, P Maity, K Singh, F Ferchiu, M Wlaschek, K Scharffetter-Kochanek |
Dermato-endocrinology | 2012 |
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Up-Regulation of leucocytes Genes Implicated in Telomere Dysfunction and Cellular Senescence Correlates with Depression and Anxiety Severity Scores
JR Teyssier, JC Chauvet-Gelinier, S Ragot, B Bonin, G Saretzki |
PloS one | 2012 |
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TAp73 depletion accelerates aging through metabolic dysregulation
A Rufini, MV Niklison-Chirou, S Inoue, R Tomasini, IS Harris, A Marino, M Federici, D Dinsdale, RA Knight, G Melino, TW Mak |
Genes & development | 2012 |
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Astrocyte Senescence as a Component of Alzheimer’s Disease
R Bhat, EP Crowe, A Bitto, M Moh, CD Katsetos, FU Garcia, FB Johnson, JQ Trojanowski, C Sell, C Torres, JC Zheng |
PloS one | 2012 |
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Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response: A senescence-like phenotype in postmitotic neurons
D Jurk, C Wang, S Miwa, M Maddick, V Korolchuk, A Tsolou, ES Gonos, C Thrasivoulou, MJ Saffrey, K Cameron, T Zglinicki |
Aging Cell | 2012 |
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Impaired autophagic function in rat islets with aging
Y Liu, S Shi, Z Gu, Y Du, M Liu, S Yan, J Gao, J Li, Y Shao, W Zhong, X Chen, C Li |
AGE | 2012 |
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Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
G David |
Cancer biology & therapy | 2012 |
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Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
ME Lee, SR Kim, S Lee, YJ Jung, SS Choi, WJ Kim, JA Han |
Experimental & molecular medicine | 2012 |
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The number of p16INK4a positive cells in human skin reflects biological age: p16INK4a in human skin reflects biological age
ME Waaijer, WE Parish, BH Strongitharm, D Heemst, PE Slagboom, AJ de Craen, JM Sedivy, RG Westendorp, DA Gunn, AB Maier |
Aging Cell | 2012 |
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Ink4-Arf locus in cancer and aging
CJ Sherr |
Wiley Interdisciplinary Reviews Developmental Biology | 2012 |
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Genetic regulation of thymocyte progenitor aging
B Berent-Maoz, E Montecino-Rodriguez, K Dorshkind |
Seminars in Immunology | 2012 |
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Translational research in immune senescence: Assessing the relevance of current models
KP High, AN Akbar, J Nikolich-Zugich |
Seminars in Immunology | 2012 |
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Mechanisms underlying the developmental origins of disease
MS Martin-Gronert, SE Ozanne |
Reviews in Endocrine and Metabolic Disorders | 2012 |
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SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
E Fagerholm, E Ahlqvist, C Forsblom, N Sandholm, A Syreeni, M Parkkonen, AJ McKnight, L Tarnow, AP Maxwell, HH Parving, L Groop, PH Groop |
Diabetologia | 2012 |
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Assessing Cell and Organ Senescence Biomarkers
BB de Jesus, MA Blasco |
Circulation research | 2012 |
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Lamin B1 loss is a senescence-associated biomarker
A Freund, RM Laberge, M Demaria, J Campisi, TM Magin |
Molecular biology of the cell | 2012 |
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DNA damage checkpoints in stem cells, ageing and cancer
T Sperka, J Wang, KL Rudolph |
Nature Reviews Molecular Cell Biology | 2012 |
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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
Velarde MC, Flynn JM, Day NU, Melov S, Campisi J |
Aging | 2012 |
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Age-related cognitive decline: Can neural stem cells help us?
Artegiani B, Calegari F |
Aging | 2012 |
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An unrestrained inflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
Anca Sindrilaru, Thorsten Peters, Stefan Wieschalka, Corina Baican, Adrian Baican, Henriette Peter, Heidi Hainzl, Susanne Schatz, Qi Yu, Andrea Schlecht, Johannes M. Weiss, Meinhard Wlaschek, Cord Sunderkoetter, Karin Scharffetter-Kochanek |
Journal of Clinical Investigation | 2011 |
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Cellular senescence and tumor suppressor gene p16
H Rayess, MB Wang, ES Srivatsan |
International Journal of Cancer | 2011 |
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Four faces of cellular senescence
F Rodier, J Campisi |
The Journal of Cell Biology | 2011 |
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Age-related changes in the function of autophagy in rat kidneys
J Cui, XY Bai, S Shi, S Cui, Q Hong, G Cai, X Chen |
AGE | 2011 |
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Regulation of senescence in cancer and aging
Y Kong, H Cui, C Ramkumar, H Zhang |
Journal of Aging Research | 2011 |
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Transgenic and knockout mice models to reveal the functions of tumor suppressor genes
P Taneja, S Zhu, D Maglic, EA Fry, RD Kendig, K Inoue |
Clinical Medicine Insights. Oncology | 2011 |
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Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks
TL Kawahara, NA Rapicavoli, AR Wu, K Qu, SR Quake, HY Chang |
PLoS genetics | 2011 |
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p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms
Y Li, TO Tollefsbol |
PloS one | 2011 |
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Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
ML Hribal, I Presta, T Procopio, MA Marini, A Stančáková, J Kuusisto, F Andreozzi, A Hammarstedt, PA Jansson, N Grarup, T Hansen, M Walker, N Stefan, A Fritsche, HU Häring, O Pedersen, U Smith, M Laakso, G Sesti |
Diabetologia | 2011 |
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Manifestations and mechanisms of stem cell aging
L Liu, TA Rando |
The Journal of Cell Biology | 2011 |
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p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages
C Cudejko, K Wouters, L Fuentes, SA Hannou, C Paquet, K Bantubungi, E Bouchaert, J Vanhoutte, S Fleury, P Remy, A Tailleux, G Chinetti-Gbaguidi, D Dombrowicz, B Staels, R Paumelle |
Blood | 2011 |
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Epigenetic Control of Aging
U Muñoz-Najar, JM Sedivy |
Antioxidants & Redox Signaling | 2011 |
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Activin A, p15INK4b Signaling, and Cell Competition Promote Stem/Progenitor Cell Repopulation of Livers in Aging Rats
A Menthena, CI Koehler, JS Sandhu, MI Yovchev, E Hurston, DA Shafritz, M Oertel |
Gastroenterology | 2011 |
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Novel ARF/p53-independent senescence pathways in cancer repression
CH Chan, Y Gao, A Moten, HK Lin |
Journal of Molecular Medicine | 2011 |
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MicroRegulators come of age in senescence
M Gorospe, K Abdelmohsen |
Trends in genetics : TIG | 2011 |
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Epigenetic regulation of caloric restriction in aging
Y Li, M Daniel, TO Tollefsbol |
BMC Medicine | 2011 |
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Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice
D Nakano, B Lei, K Kitada, H Hitomi, H Kobori, H Mori, K Deguchi, T Masaki, T Minamino, A Nishiyama |
American Journal of Hypertension | 2011 |
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The Regulatory Mechanisms of Tumor Suppressor P16INK4A and Relevance to Cancer†
J Li, MJ Poi, MD Tsai |
Biochemistry | 2011 |
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Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
JP Coppé, F Rodier, CK Patil, A Freund, PY Desprez, J Campisi |
The Journal of biological chemistry | 2011 |
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INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury
DH Lee, JM Wolstein, B Pudasaini, M Plotkin |
2011 | |
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Chemokines and BPH/LUTS
JA Macoska |
Differentiation | 2011 |
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Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression
H Li, Y Wang, SK Pazhanisamy, L Shao, I Batinic-Haberle, A Meng, D Zhou |
Free radical biology & medicine | 2011 |
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Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging
Z Ju, J Zhang, Y Gao, T Cheng |
International Journal of Hematology | 2011 |
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Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
D Nakada, BP Levi, SJ Morrison |
Neuron | 2011 |
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Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition
K Tamama, H Kawasaki, SS Kerpedjieva, J Guan, RK Ganju, CK Sen |
Journal of Cellular Biochemistry | 2011 |
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Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis
JN Min, C Patterson |
Methods | 2011 |
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The p53 tumor suppressor protein regulates hematopoietic stem cell fate
T Asai, Y Liu, N Bae, SD Nimer |
Journal of Cellular Physiology | 2011 |
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
DJ Baker, T Wijshake, T Tchkonia, NK LeBrasseur, BG Childs, B de Sluis, JL Kirkland, JM van Deursen |
Nature | 2011 |
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Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence: Smurf2 regulates p16 through ubiquitination of Id1
Y Kong, H Cui, H Zhang |
Aging Cell | 2011 |
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p16INK4a Expression and Breast Cancer Risk in Women with Atypical Hyperplasia
DC Radisky, M Santisteban, HK Berman, ML Gauthier, MH Frost, CA Reynolds, RA Vierkant, VS Pankratz, DW Visscher, TD Tlsty, LC Hartmann |
Cancer prevention research (Philadelphia, Pa.) | 2011 |
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Cellular senescence: A link between cancer and age-related degenerative disease?
J Campisi, JK Andersen, P Kapahi, S Melov |
Seminars in Cancer Biology | 2011 |
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Is cellular senescence important in pediatric kidney disease?
C Jacobi, M Hömme, A Melk |
Pediatric Nephrology | 2011 |
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Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis
P Beukelaers, R Vandenbosch, N Caron, L Nguyen, G Moonen, B Malgrange |
Cellular and Molecular Life Sciences | 2011 |
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Overexpression of the Cell Cycle Inhibitor p16 INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice
JC Cardenas, AP Owens, J Krishnamurthy, NE Sharpless, HC Whinna, FC Church |
Arteriosclerosis, thrombosis, and vascular biology | 2011 |
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DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
F Rodier, DP Muñoz, R Teachenor, V Chu, O Le, D Bhaumik, JP Coppé, E Campeau, CM Beauséjour, SH Kim, AR Davalos, J Campisi |
Journal of cell science | 2011 |
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Roles of FGF signaling in stem cell self-renewal, senescence and aging
Coutu DL, Galipeau J |
Aging | 2011 |
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Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model
Zhang X, Zhou D, Strakovsky R, Zhang Y, Pan YX |
AJP Gastrointestinal and Liver Physiology | 2011 |
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Reversing B cell aging
Mehr R, Melamed D |
Aging | 2011 |
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Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
ON Le, F Rodier, F Fontaine, JP Coppe, J Campisi, J DeGregori, C Laverdière, V Kokta, E Haddad, CM Beauséjour |
Aging Cell | 2010 |
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Bim dictates naïve CD4 T cell lifespan and the development of age-associated functional defects1
H Tsukamoto, GE Huston, J Dibble, DK Duso, SL Swain |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
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Decreased IRS Signaling Impairs -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in -Cells
L Elghazi, N Balcazar, M Blandino-Rosano, C Cras-Meneur, S Fatrai, AP Gould, MM Chi, KH Moley, E Bernal-Mizrachi |
Diabetes | 2010 |
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Fat tissue, aging, and cellular senescence
T Tchkonia, DE Morbeck, TV Zglinicki, JV Deursen, J Lustgarten, H Scrable, S Khosla, MD Jensen, JL Kirkland |
Aging Cell | 2010 |
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Senescent cells as a source of inflammatory factors for tumor progression
AR Davalos, JP Coppe, J Campisi, PY Desprez |
Cancer and Metastasis Reviews | 2010 |
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Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
KE Lee, D Bar-Sagi |
Cancer Cell | 2010 |
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Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways
AD Rhim, BZ Stanger |
Progress in molecular biology and translational science | 2010 |
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Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
CE Burd, WR Jeck, Y Liu, HK Sanoff, Z Wang, NE Sharpless |
PLoS genetics | 2010 |
|
Polycomb group proteins are key regulators of keratinocyte function
RL Eckert, G Adhikary, EA Rorke, YC Chew, S Balasubramanian |
Journal of Investigative Dermatology | 2010 |
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A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1
M Negishi, A Saraya, S Mochizuki, K Helin, H Koseki, A Iwama |
PloS one | 2010 |
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Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding
C Mück, D Herndler-Brandstetter, L Micutkova, B Grubeck-Loebenstein, P Jansen-Dürr |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2010 |
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Feedback between p21 and reactive oxygen production is necessary for cell senescence
JF Passos, G Nelson, C Wang, T Richter, C Simillion, CJ Proctor, S Miwa, S Olijslagers, J Hallinan, A Wipat, G Saretzki, KL Rudolph, TB Kirkwood, T Zglinicki |
Molecular Systems Biology | 2010 |
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Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals
N Ohtani, K Yamakoshi, A Takahashi, E Hara |
Cell division | 2010 |
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Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
R Mukhopadhyay, SV Costes, AV Bazarov, WC Hines, MH Barcellos-Hoff, P Yaswen |
Breast Cancer Research | 2010 |
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Tail Tendon Break Time: A Biomarker of Aging?
LB Sloane, JT Stout, SN Austad, GE McClearn |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2010 |
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Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene
Y Kotake, T Nakagawa, K Kitagawa, S Suzuki, N Liu, M Kitagawa, Y Xiong |
Oncogene | 2010 |
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INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction
JM Wolstein, DH Lee, J Michaud, V Buot, B Stefanchik, MD Plotkin |
AJP Renal Physiology | 2010 |
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Tgfβ Signaling Directly Induces Arf Promoter Remodeling by a Mechanism Involving Smads 2/3 and p38 MAPK*
Y Zheng, YD Zhao, M Gibbons, T Abramova, PY Chu, JD Ash, JM Cunningham, SX Skapek |
The Journal of biological chemistry | 2010 |
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Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis
MJ Drummond, JJ McCarthy, M Sinha, HM Spratt, E Volpi, KA Esser, BB Rasmussen |
Physiological genomics | 2010 |
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Insights into aging through measurements of the Drosophila proteome as a function of temperature
RA Robinson, JF Kellie, TC Kaufman, DE Clemmer |
Mechanisms of Ageing and Development | 2010 |
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Chromatin: a molecular interface between cancer and aging
HA Cruickshanks, PD Adams |
Current Opinion in Genetics & Development | 2010 |
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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
D Herranz, M Muñoz-Martin, M Cañamero, F Mulero, B Martinez-Pastor, O Fernandez-Capetillo, M Serrano |
Nature Communications | 2010 |
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B-MYB delays cell aging by repressing p16 INK4α transcription
Y Huang, J Wu, R Li, P Wang, L Han, Z Zhang, T Tong |
Cellular and Molecular Life Sciences | 2010 |
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Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health
N Popov, J Gil |
Epigenetics : official journal of the DNA Methylation Society | 2010 |
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Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging
JH Ford |
AGE | 2010 |
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Apoptosis and aging: increased resistance to apoptosis enhances the aging process
A Salminen, J Ojala, K Kaarniranta |
Cellular and Molecular Life Sciences | 2010 |
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Age-associated increase in heterochromatic marks in murine and primate tissues: Age-associated increase in heterochromatic marks
JA Kreiling, M Tamamori-Adachi, AN Sexton, JC Jeyapalan, U Munoz-Najar, AL Peterson, J Manivannan, ES Rogers, NA Pchelintsev, PD Adams, JM Sedivy |
Aging Cell | 2010 |
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Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood: Measuring the influence of lifestyle on aging
Z Song, GV Figura, Y Liu, JM Kraus, C Torrice, P Dillon, M Rudolph-Watabe, Z Ju, HA Kestler, H Sanoff, KL Rudolph |
Aging Cell | 2010 |
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Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria: Age-dependent cardiomyopathy in mitochondrial mutator mice
DF Dai, T Chen, J Wanagat, M Laflamme, DJ Marcinek, MJ Emond, CP Ngo, TA Prolla, PS Rabinovitch |
Aging Cell | 2010 |
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Inflammatory networks during cellular senescence: causes and consequences
A Freund, AV Orjalo, PY Desprez, J Campisi |
Trends in Molecular Medicine | 2010 |
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Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
Y Li, L Liu, TO Tollefsbol |
The FASEB Journal | 2010 |
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MicroRNA (miRNA)-mediated Interaction between Leukemia/Lymphoma-related Factor (LRF) and Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) Affects Mouse Embryonic Fibroblast Senescence and Apoptosis
L Verduci, M Simili, M Rizzo, A Mercatanti, M Evangelista, L Mariani, G Rainaldi, L Pitto |
The Journal of biological chemistry | 2010 |
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Ras-induced senescence and its physiological relevance in cancer.
Dimauro T, David G |
Current cancer drug targets | 2010 |
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Adult-onset, short-term dietary restriction reduces cell senescence in mice.
Wang C, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SA, Godschalk RW, Cameron K, von Zglinicki T |
Aging | 2010 |
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Activation of senescence and aging characteristics by mitochondrially generated ROS: how are they linked?
Papaconstantinou J, Hsieh CC |
Cell cycle (Georgetown, Tex.) | 2010 |
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Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
K Yamakoshi, A Takahashi, F Hirota, R Nakayama, N Ishimaru, Y Kubo, DJ Mann, M Ohmura, A Hirao, H Saya, S Arase, Y Hayashi, K Nakao, M Matsumoto, N Ohtani, E Hara |
The Journal of Cell Biology | 2009 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation
S Dhawan, SI Tschen, A Bhushan |
Genes & development | 2009 |
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Heterogeneity in mitotic activity and telomere length implies an important role of young islets in the maintenance of islet mass in the adult pancreas
S Peng, L Zhu, M Chen, M Zhang, D Li, Y Fu, S Chen, C Wei |
Endocrinology | 2009 |
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Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
H Chen, X Gu, I Su, R Bottino, JL Contreras, A Tarakhovsky, SK Kim |
Genes & development | 2009 |
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Genetic epidemiology in aging research
MD Fallin, A Matteini |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2009 |
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Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
WR Swindell |
BMC Genomics | 2009 |
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Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
Y Wang, L Liu, SK Pazhanisamy, H Li, A Meng, D Zhou |
Free radical biology & medicine | 2009 |
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A quantitative model for age-dependent expression of the p16INK4a tumor suppressor
D Tsygankov, Y Liu, HK Sanoff, NE Sharpless, TC Elston |
Proceedings of the National Academy of Sciences | 2009 |
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p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence
K Fujita, AM Mondal, I Horikawa, GH Nguyen, K Kumamoto, JJ Sohn, ED Bowman, EA Mathe, AJ Schetter, SR Pine, H Ji, B Vojtesek, JC Bourdon, DP Lane, CC Harris |
Nature Cell Biology | 2009 |
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Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
GW Hinkal, CE Gatza, N Parikh, LA Donehower |
Mechanisms of Ageing and Development | 2009 |
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Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice
A Gromley, ML Churchman, F Zindy, CJ Sherr |
Proceedings of the National Academy of Sciences | 2009 |
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JDP2 (Jun Dimerization Protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence
K Nakade, J Pan, T Yamasaki, T Murata, B Wasylyk, KK Yokoyama |
The Journal of biological chemistry | 2009 |
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The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity
W Chatoo, M Abdouh, J David, MP Champagne, J Ferreira, F Rodier, G Bernier |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2009 |
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The ageing immune system: is it ever too old to become young again?
K Dorshkind, E Montecino-Rodriguez, RA Signer |
Nature Reviews Immunology | 2009 |
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Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice
M Khan, S Mohsin, SN Khan, S Riazuddin |
Journal of Cellular and Molecular Medicine | 2009 |
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Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
M Mimeault, SK Batra |
2009 | |
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Senescence and life span
PJ Hornsby |
Pflügers Archiv - European Journal of Physiology | 2009 |
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Tumor suppressor mechanisms in immune aging
Y Liu, NE Sharpless |
Current Opinion in Immunology | 2009 |
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Adaptive -Cell Proliferation Is Severely Restricted With Advanced Age
MM Rankin, JA Kushner |
Diabetes | 2009 |
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Cellular senescence: Its role in tumor suppression and aging
N Ohtani, DJ Mann, E Hara |
Cancer Science | 2009 |
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Expression of p16 INK4a in peripheral blood T-cells is a biomarker of human aging
Y Liu, HK Sanoff, H Cho, CE Burd, C Torrice, JG Ibrahim, NE Thomas, NE Sharpless |
Aging Cell | 2009 |
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Humane Papillomviren in der Pathogenese der intraepithelialen Neoplasien (AIN) und Karzinome des Anus
MK Doeberitz, M Reuschenbach |
Der Hautarzt | 2009 |
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p53 — a Jack of all trades but master of none
MR Junttila, GI Evan |
Nature Reviews Cancer | 2009 |
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Role of telomere dysfunction in aging and its detection by biomarkers
G Figura, D Hartmann, Z Song, KL Rudolph |
Journal of Molecular Medicine | 2009 |
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Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells
J Lee, CG Lee, KW Lee, CW Lee |
Experimental & molecular medicine | 2009 |
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The Ink4/Arf locus is a barrier for iPS cell reprogramming
H Li, M Collado, A Villasante, K Strati, S Ortega, M Cañamero, MA Blasco, M Serrano |
Nature | 2009 |
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CDK Inhibitor p18INK4c Is a Downstream Target of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis
XH Pei, F Bai, MD Smith, J Usary, C Fan, SY Pai, IC Ho, CM Perou, Y Xiong |
Cancer Cell | 2009 |
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The 9p21 Myocardial Infarction Risk Allele Increases Risk of Peripheral Artery Disease in Older People
C Cluett, MM McDermott, J Guralnik, L Ferrucci, S Bandinelli, I Miljkovic, JM Zmuda, R Li, G Tranah, T Harris, N Rice, W Henley, TM Frayling, A Murray, D Melzer |
Circulation. Cardiovascular genetics | 2009 |
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Alterations in transcriptional responses associated with vascular aging
Y Zhan, L Yuan, P Oettgen |
Journal of Inflammation | 2009 |
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DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16 INK4a Activation
Y Kotake, Y Zeng, Y Xiong |
Cancer research | 2009 |
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A structural basis for cellular senescence
Aranda-Anzaldo A |
Aging | 2009 |
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A common biological mechanism in cancer and Alzheimer's disease?
Behrens MI, Lendon C, Roe CM |
Current Alzheimer research | 2009 |
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Aging of the inceptive cellular population: the relationship between stem cells and aging.
Symonds CE, Galderisi U, Giordano A |
Aging | 2009 |
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Paradoxical down-regulation of p16 mRNA with advancing age in acute myeloid leukemia.
de Jonge HJ, Woolthuis CM, de Bont ES, Huls G |
Aging | 2009 |
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Knockout of Ku86 accelerates cellular senescence induced by high NaCl
Dmitrieva NI, Chen HT, Nussenzweig A, Burg MB |
Aging | 2009 |
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Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein
D Miao, H Su, B He, J Gao, Q Xia, M Zhu, Z Gu, D Goltzman, AC Karaplis |
Proceedings of the National Academy of Sciences | 2008 |
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Stem cell review series: role of neurogenesis in age-related memory disorders
E Drapeau, DN Abrous |
Aging Cell | 2008 |
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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
DJ Baker, C Perez-Terzic, F Jin, KS Pitel, K Pitel, NJ Niederländer, K Jeganathan, S Yamada, S Reyes, L Rowe, HJ Hiddinga, NL Eberhardt, A Terzic, JM van Deursen |
Nature Cell Biology | 2008 |
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Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
SK Heathfield, CL le Maitre, JA Hoyland |
Arthritis Research & Therapy | 2008 |
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Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf
RA Signer, E Montecino-Rodriguez, ON Witte, K Dorshkind |
Genes & development | 2008 |
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p16(INK4a) translation suppressed by miR-24
A Lal, HH Kim, K Abdelmohsen, Y Kuwano, R Pullmann, S Srikantan, R Subrahmanyam, JL Martindale, X Yang, F Ahmed, F Navarro, D Dykxhoorn, J Lieberman, M Gorospe |
PloS one | 2008 |
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SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
J Huang, Q Gan, L Han, J Li, H Zhang, Y Sun, Z Zhang, T Tong |
PloS one | 2008 |
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Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
JP Dean, PS Nelson |
British Journal of Cancer | 2008 |
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Aging by epigenetics—A consequence of chromatin damage?
JM Sedivy, G Banumathy, PD Adams |
Experimental Cell Research | 2008 |
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Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
J Nishino, I Kim, K Chada, SJ Morrison |
Cell | 2008 |
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Cellular senescence and organismal aging
JC Jeyapalan, JM Sedivy |
Mechanisms of Ageing and Development | 2008 |
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Replicative stress, stem cells and aging
Y Ruzankina, A Asare, EJ Brown |
Mechanisms of Ageing and Development | 2008 |
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Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo
S Panda, A Isbatan, GR Adami |
Mechanisms of Ageing and Development | 2008 |
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CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control
JN Min, RA Whaley, NE Sharpless, P Lockyer, AL Portbury, C Patterson |
Molecular and cellular biology | 2008 |
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Genome-wide association study of susceptibility alleles for coronary artery disease.
Marian AJ |
Current Atherosclerosis Reports | 2008 |
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Wnt signaling and senescence: a tug of war in early neoplasia?
Adams PD, Enders GH |
Cancer biology & therapy | 2008 |
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The yin and yang of the Cdkn2a locus in senescence and aging
Baker DJ, Jin F, van Deursen JM |
Cell cycle (Georgetown, Tex.) | 2008 |
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Differential post-transcriptional regulation of two Ink4 proteins, p18Ink4c and p19Ink4d
Forget A, Ayrault O, den Besten W, Kuo ML, Sherr CJ, Roussel MF |
Cell cycle (Georgetown, Tex.) | 2008 |
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Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.
Nishino J, Kim I, Chada K, Morrison SJ |
Cell | 2008 |
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A common variant of the p16(INK4a) genetic region is associated with physical function in older people
D Melzer, TM Frayling, A Murray, AJ Hurst, LW Harries, H Song, K Khaw, R Luben, PG Surtees, SS Bandinelli, AM Corsi, L Ferrucci, JM Guralnik, RB Wallace, AT Hattersley, PD Pharoah |
Mechanisms of Ageing and Development | 2007 |
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Formation and regeneration of the endocrine pancreas
S Dhawan, S Georgia, A Bhushan |
Current Opinion in Cell Biology | 2007 |
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Cardiac myocyte cell cycle control in development, disease, and regeneration
P Ahuja, P Sdek, WR MacLellan |
Physiological reviews | 2007 |
|
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
MG Edwards, RM Anderson, M Yuan, CM Kendziorski, R Weindruch, TA Prolla |
BMC Genomics | 2007 |
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DNA damage, cellular senescence and organismal ageing: causal or correlative?
JH Chen, CN Hales, SE Ozanne |
Nucleic Acids Research | 2007 |
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Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
CL le Maitre, AJ Freemont, JA Hoyland |
Arthritis Research & Therapy | 2007 |
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Motif module map reveals enforcement of aging by continual NF-kappaB activity
AS Adler, S Sinha, TL Kawahara, JY Zhang, E Segal, HY Chang |
Genes & development | 2007 |
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Relationships between stem cell exhaustion, tumour suppression and ageing
Y Ruzankina, EJ Brown |
British Journal of Cancer | 2007 |
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Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals
N Ohtani, Y Imamura, K Yamakoshi, F Hirota, R Nakayama, Y Kubo, N Ishimaru, A Takahashi, A Hirao, T Shimizu, DJ Mann, H Saya, Y Hayashi, S Arase, M Matsumoto, N Kazuki, E Hara |
Proceedings of the National Academy of Sciences | 2007 |
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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
YY Jang, SJ Sharkis |
Blood | 2007 |
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Early Embryonic Lethality of Mice Lacking the Essential Protein SNEV
K Fortschegger, B Wagner, R Voglauer, H Katinger, M Sibilia, J Grillari |
Molecular and cellular biology | 2007 |
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AGEMAP: A Gene Expression Database for Aging in Mice
JM Zahn, S Poosala, AB Owen, DK Ingram, A Lustig, A Carter, AT Weeraratna, DD Taub, M Gorospe, K Mazan-Mamczarz, EG Lakatta, KR Boheler, X Xu, MP Mattson, G Falco, MS Ko, D Schlessinger, J Firman, SK Kummerfeld, WH Wood, AB Zonderman, SK Kim, KG Becker, WN Frankel |
PLoS genetics | 2007 |
|
State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective
RM Tuder, T Yoshida, W Arap, R Pasqualini, I Petrache |
Proceedings of the American Thoracic Society | 2006 |
|
Cigarette smoke induces cellular senescence
T Nyunoya, MM Monick, A Klingelhutz, TO Yarovinsky, JR Cagley, GW Hunninghake |
American journal of respiratory cell and molecular biology | 2006 |
|
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
AV Molofsky, SG Slutsky, NM Joseph, S He, R Pardal, J Krishnamurthy, NE Sharpless, SJ Morrison |
Nature | 2006 |
|
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a)
I Guney, S Wu, JM Sedivy |
Proceedings of the National Academy of Sciences | 2006 |
|
Total body irradiation selectively induces murine hematopoietic stem cell senescence
Y Wang, BA Schulte, AC LaRue, M Ogawa, D Zhou |
Blood | 2006 |
|
Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature
JM Zahn, R Sonu, H Vogel, E Crane, K Mazan-Mamczarz, R Rabkin, RW Davis, KG Becker, AB Owen, SK Kim, W Frankel |
PLoS genetics | 2006 |
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Induction of the Tumor-Suppressor p16INK4a within Regenerative Epithelial Crypts in Ulcerative Colitis
Furth EE, Gustafson KS, Dai CY, Gibson SL, Menard-Katcher P, Chen T, Koh J, Enders GH |
Neoplasia (New York, N.Y.) | 2006 |
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Transcriptional profiling of aging in human muscle reveals a common aging signature.
Zahn JM, Sonu R, Vogel H, Crane E, Mazan-Mamczarz K, Rabkin R, Davis RW, Becker KG, Owen AB, Kim SK |
PLoS genetics | 2006 |
|
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
WM Keyes, Y Wu, H Vogel, X Guo, SW Lowe, AA Mills |
Genes & development | 2005 |
|
The expression signature of in vitro senescence resembles mouse but not human aging
K Wennmalm, C Wahlestedt, O Larsson |
Genome biology | 2005 |
|
Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function
J Hu, SZ Imam, K Hashiguchi, NC de Souza-Pinto, VA Bohr |
Nucleic Acids Research | 2005 |
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The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
A Lechel, A Satyanarayana, Z Ju, RR Plentz, S Schaetzlein, C Rudolph, L Wilkens, SU Wiemann, G Saretzki, NP Malek, MP Manns, J Buer, KL Rudolph |
EMBO reports | 2005 |
|
p16 and ARF: activation of teenage proteins in old age
A Satyanarayana, KL Rudolph |
Journal of Clinical Investigation | 2004 |
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