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Citations to this article

Leptin action in the forebrain regulates the hindbrain response to satiety signals
Gregory J. Morton, … , Denis G. Baskin, Michael W. Schwartz
Gregory J. Morton, … , Denis G. Baskin, Michael W. Schwartz
Published March 1, 2005
Citation Information: J Clin Invest. 2005;115(3):703-710. https://doi.org/10.1172/JCI22081.
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Article Metabolism Article has an altmetric score of 12

Leptin action in the forebrain regulates the hindbrain response to satiety signals

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Abstract

The capacity to adjust energy intake in response to changing energy requirements is a defining feature of energy homeostasis. Despite the identification of leptin as a key mediator of this process, the mechanism whereby changes of body adiposity are coupled to adaptive, short-term adjustments of energy intake remains poorly understood. To investigate the physiological role of leptin in the control of meal size and the response to satiety signals, and to identify brain areas mediating this effect, we studied Koletsky (fak/fak) rats, which develop severe obesity due to the genetic absence of leptin receptors. Our finding of markedly increased meal size and reduced satiety in response to the gut peptide cholecystokinin (CCK) in these leptin receptor–deficient animals suggests a critical role for leptin signaling in the response to endogenous signals that promote meal termination. To determine if the hypothalamic arcuate nucleus (ARC) (a key forebrain site of leptin action) mediates this leptin effect, we used adenoviral gene therapy to express either functional leptin receptors or a reporter gene in the area of the ARC of fak/fak rats. Restoration of leptin signaling to this brain area normalized the effect of CCK on the activation of neurons in the nucleus of the solitary tract and area postrema, key hindbrain areas for processing satiety-related inputs. This intervention also reduced meal size and enhanced CCK-induced satiety in fak/fak rats. These findings demonstrate that forebrain signaling by leptin, a long-term regulator of body adiposity, limits food intake on a meal-to-meal basis by regulating the hindbrain response to short-acting satiety signals.

Authors

Gregory J. Morton, James E. Blevins, Diana L. Williams, Kevin D. Niswender, Richard W. Gelling, Christopher J. Rhodes, Denis G. Baskin, Michael W. Schwartz

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Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 1 3 4 3 6 3 3 4 8 8 2 9 11 12 10 10 2 4 103
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (11)

Title and authors Publication Year
Leptin receptor expression in mouse hindbrain Glp-1 neurons regulates food intake and energy balance
michael scott, kevin williams, Jari Rossi, charlotte lee, Joel Elmquist
Journal of Clinical Investigation 2011
Neuroanatomy of Body Weight Control: Lessons Learned from Leptin
Diana Williams, Michael W Schwartz
Journal of Clinical Investigation 2011
Leptin as an Adolescent: An Update on Leptin Regulation of Energy Balance
Laurent Gautron, Joel Elmquist
Journal of Clinical Investigation 2011
Central leptin and ghrelin signalling: Comparing and contrasting their mechanisms of action in the brain
X Shan, GS Yeo
Reviews in Endocrine and Metabolic Disorders 2011
Leptin and the CNS Control of Glucose Metabolism
GJ Morton, MW Schwartz
Physiological reviews 2011
GLP-1 and energy balance: an integrated model of short-term and long-term control
JG Barrera, DA Sandoval, DA D'Alessio, RJ Seeley
Nature Reviews Endocrinology 2011
Biology's response to dieting: the impetus for weight regain
PS Maclean, A Bergouignan, MA Cornier, MR Jackman
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2011
Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice
CD Richard, V Tolle, MJ Low
European Journal of Pharmacology 2011
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
GJ Morton, BS Thatcher, RD Reidelberger, K Ogimoto, T Wolden-Hanson, DG Baskin, MW Schwartz, JE Blevins
American journal of physiology. Endocrinology and metabolism 2011
Evidence for the role of hindbrain orexin-1 receptors in the control of meal size
EM Parise, N Lilly, K Kay, AM Dossat, R Seth, JM Overton, DL Williams
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2011
Adiposity signaling and meal size control
TH Moran, EE Ladenheim
Physiology & Behavior 2011

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