Citations to this article

Undermining the endothelium by ablation of MAPK-MEF2 signaling
Eric N. Olson
Eric N. Olson
Published April 15, 2004
Citation Information: J Clin Invest. 2004;113(8):1110-1112. https://doi.org/10.1172/JCI21497.
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Undermining the endothelium by ablation of MAPK-MEF2 signaling

Abstract

Numerous stimuli activate Big MAPK-1 (BMK1), an MAPK that activates the myocyte enhancer factor-2 (MEF2) transcription factor. Conditional gene deletion showed BMK1 to be required for survival of endothelial cells. An active form of MEF2C could partially bypass the requirement for BMK1 for endothelial cell survival in vitro. These findings reveal an essential role for BMK1-MEF2 signaling in an endothelial cell survival pathway and raise interesting questions about the molecular basis of this response.

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Eric N. Olson

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Citations to this article (16)

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